valproic acid and dipropylacetamide

valproic acid has been researched along with dipropylacetamide in 118 studies

Research

Studies (118)

Timeframe	Studies, this research(%)	All Research%
pre-1990	50 (42.37)	18.7374
1990's	20 (16.95)	18.2507
2000's	32 (27.12)	29.6817
2010's	11 (9.32)	24.3611
2020's	5 (4.24)	2.80

Authors

Authors	Studies
Geurts, M; Lambert, DM; Poupaert, JH; Scriba, GK	1
Bruno-Blanch, L; Gálvez, J; García-Domenech, R	1
Brenstrum, T; Capretta, A; Kim, AJ; Ohnmacht, SA; Panna, E; Werstuck, GH	1
Bialer, M; Finnell, RH; Shimshoni, JA; Wlodarczyk, B; Yagen, B	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Bialer, M; Finnell, RH; Pessah, N; Wlodarczyk, B; Yagen, B	1
Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Di Perri, R; Nistico, G; Pisani, F	1
Semadeni, GW	1
Bialer, M; Hadad, S; Haj-Yehia, A	1
Miljković, B; Pokrajac, M; Spiridonović, D; Varagić, VM	1
Wieser, HG	2
Eugster, HP; Hinnen, A; Meyer, UA; Sengstag, C; Würgler, FE	1
Bialer, M	2
Barzaghi, N; Bialer, M; Haj-Yehia, A; Perucca, E; Pisani, F	1
Nishikawa, T; Scatton, B; Serrano, A	1
Bulat, M; Jernej, B; Oresković, D; Plavsić, F; Radacić, M; Whitton, PS	1
Giuliani, L; Oesch, F; Pacifici, GM; Rane, A; Temellini, A; Thomas, H	1
Eddy, AC; Guyot, M; Kerr, BM; Levy, RH; Loiseau, P; Rettie, AE; Wilensky, AJ	1
Bialer, M; Haj-Yehia, A	2
Kerr, BM; Levy, RH	1
Bertilsson, L; Pacifici, GM; Rane, A; Tomson, T	1
Alhayek, G; Alquier, P; Bourrier, P; Kamoun, P; Lorre, G; Rabier, D; Varache, N	1
Bencini, C; Franchi, M; Pacifici, GM; Rane, A	1
Shi, FL	1
Friedman, M; Gonen, A; Rubinstein, A	1
Pacifici, GM; Rane, A	1
Kabes, J; Peterová, E; Vencovský, E	1
Hanus, H; Kindernayová, H; Zapletálek, M	1
Bertilsson, L; Fazio, A; Oteri, G; Perucca, E; Pisani, F; Spina, E	1
Campanella, G; Capone, D; De Marino, V; Del Rio, A; Pisanti, N	1
Allers, G; Bertschy, G; Jounet, JM; Vandel, S	1
Zhou, SS	1
Di Perri, R; Fazio, A; Oteri, G; Pisani, F	2
Bialer, M; Rubinstein, A	1
Kłosiewicz, L; Puzyński, S	2
Binnie, CD; de Beer-Pawlikowski, NK; Debets, RM; Meijer, JW; van Parys, JA	1
Ehlers, CL; Killam, EK; Mulbry, LW	1
Bulat, M; Marković, Z; Oresković, D; Skarpa, D; Whitton, PS	1
Monaco, F; Piredda, S	1
Soucek, K; Vencovský, E; Zatecká, I	2
Di Perri, R; Fazio, A; Oteri, G; Pisani, F; Spina, E; Trunfio, C	1
Battistin, L; Berlese, G; Roman, G; Varotto, M	1
Amico-Roxas, M; Continella, G; Drago, F; Scapagnini, U	1
Depaulis, A; Vergnes, M	1
Abramsky, O; Bialer, M; Raz, I; Rubinstein, A	1
Gedan, A; Kleemann, V; Pfeifer, S	1
Di Perri, R; Gallitto, G; Morgante, L; Musolino, R; Pisani, F	1
Di Perri, R; Gallitto, G; Morgante, L; Musolino, R; Natoli, M; Pisani, F; Serra, S	1
Bartholini, G; Scatton, B	1
De Sarro, A; Fazio, A; Oteri, G; Pisani, F	1
Caruso, C; Celentano, I; Gentile, A; Puccini, A	1
Di Perri, R; Gallitto, G; Musolino, R; Pisani, F	2
Di Perri, R; Gallitto, G; Morgante, L; Musolino, R; Nisticò, G; Pisani, F	1
Di Perri, R; Pisani, F	1
Beretta, G; Bocci, U	1
D'Agostino, AA; Di Perri, R; Fazio, A; Oteri, G; Pisani, F; Primerano, G	1
Albani, F; Baruzzi, A; Olivi, F; Pantaloni, M; Riva, R	1
Bialer, M; Hadad, S	1
Badir, K; Bialer, M; Hadad, S; Haj-Yehia, A	1
Eugster, HP; Sengstag, C	1
Bergman, F; Bialer, M; Blotnik, S	1
Abdul-Hai, A; Bialer, M; Hadad, S; Haj-Yehia, A; Herzig, Y; Kadry, B; Sterling, J; Yagen, B	1
Bialer, M; Levi, M; Yagen, B	1
Bialer, M; Ehlers, K; Nau, H; Radatz, M; Yagen, B	1
Armand, V; Heinemann, U; Louvel, J; Pumain, R	1
Bialer, M; Haj-Yehia, A; Hurst, SI; Kroetz, DL; Levi, M; Levy, RH; Spiegelstein, O; Yagen, B	1
Faivre, T; Fondarai, J; Lemoine, P	1
Bialer, M; Ebinger, G; Khan, GM; Lindekens, H; Michotte, Y; Smolders, I	1
Bialer, M; Blotnik, S; Papo, N; Wasserman, M; Yagen, B	1
Hardy-Baylé, MC	1
Chen, Y; Costa, E; Costa, RH; Grayson, DR; Sharma, RP	1
Beylot, J; Bonnet, F; Combe, C; De Witte, S; Morlat, P	1
Bialer, M; Isoherranen, N; Yagen, B	1
Chakraborty, N; Chandran, S; Harris, M; Healy, D	1
Aoki, Y; Bialer, M; Fujiwara, M; Kurihara, H; Okada, A	1
Descotes, J; Frantz, P; Martin, O; Moulsma, M; Parant, F; Payen, C; Pulce, C	1
Bruno-Blanch, LE; Estiú, GL; Moon, SCh; Tasso, SM	1
Auffray, JP; Blayac, D; De Francheschi, E; Michelet, P; Roch, A	1
Aoki, Y; Bialer, M; Fujiwara, M; Kurihara, H; Kushima, K; Okada, A	1
Agam, G; Belmaker, RH; Bialer, M; Dalton, E; Ding, D; Greenberg, ML; Harwood, AJ; Shaltiel, G; Shamir, A; Shapiro, J	1
Akiskal, HS; Chatenêt-Duchêne, L; Hantouche, EG; Lancrenon, S	1
Avila, AM; Fischbeck, KH; Huynh, TN; Kernochan, LE; Russo, ML; Sumner, CJ; Woodling, NS	1
Aoki, Y; Bialer, M; Fujiwara, M; Kushima, K; Okada, A	1
Bialer, M; Blotnik, S; Devor, M; Shimshoni, J; Winkler, I; Yagen, B	1
Hallberg, BM; Himo, F; Hopmann, KH	1
Brixner, DI; Gunter, MJ; Rosenberg, JH; Suter, CC; Trost, LF; Von Worley, AM; Wender, RC	1
Bialer, M; Dalton, EC; Ewan, K; Eyal, S; Harwood, AJ; Jenkins, A; Pessah, N; Shimshoni, JA; Williams, RS; Yagen, B	1
Calabrese, JR; Guelfi, JD; Perdrizet-Chevallier, C	1
Canonico, PL; Condorelli, F; Genazzani, AA; Gnemmi, I; Vallario, A	1
Chatterjie, N; Grundke-Iqbal, I; Iqbal, K; Wang, JZ; Wang, XC; Zhang, YC	1
Cesková, E; Rysánek, R; Svestka, J	1
Cesková, E; Náhunek, K; Obrovská, V; Rysánek, R; Svestka, J	1
Chuang, DM; Leeds, P; Leng, Y; Liang, MH; Marinova, Z; Ren, M; Wendland, JR; Yasuda, S	1
Gao, ZG; Mao, ZN; Wang, SB; Zhang, GW	1
Hales, BF; Paradis, FH	2
Das, G; Jagtap, JC; Mruthyunjaya, S; Pujari, R; Shah, RD; Shastry, P; Shelke, GV	1
Denora, N; Franco, M; Laquintana, V; Lasorsa, FM; Margiotta, N; Natile, G; Piccinonna, S	1
Darcissac, C; de La Gastine, B; Gabriel, L; Goutelle, S; Sève, P; Vial, T	1
Daigle, D; Gorres, KL; Lyons, DE; McInerney, GE; Miller, G; Mohanram, S	1
Davis, JN; Gorres, KL; Miller, G; Ornaghi, S; Paidas, MJ; van den Pol, AN	1
Katz, A; Pérez-Kempner, ML; Saenz-Méndez, P; Vázquez, M; Ventura, ON	1
Araujo, M; Benevent, J; Damase-Michel, C; Durrieu, G; Foch, C; Lacroix, I; Montastruc, JL; Weckel, A	1
Bello-Morales, R; de Castro, F; López-Guerrero, JA; Praena, B	1
Alili, N; Chabriat, H; Hervé, D; Jouvent, E	1
Boels, D; Bouquié, R; Mégarbane, B	1
Andreu, S; Bello-Morales, R; López-Guerrero, JA; Praena, B; Ripa, I	1
Besson, VC; Blaise, N; Bloch, V; Chouchana, M; Delage, C; Etain, B; Hagenimana, M; Palayer, M; Smati, J	1

Reviews

5 review(s) available for valproic acid and dipropylacetamide

Article	Year
Clinical pharmacology of valpromide. Clinical pharmacokinetics, 1991, Volume: 20, Issue:2 Topics: Amitriptyline; Animals; Anticonvulsants; Biological Availability; Carbamazepine; Drug Interactions; Humans; Valproic Acid	1991
Can we develop improved derivatives of valproic acid? Pharmacy world & science : PWS, 1994, Feb-18, Volume: 16, Issue:1 Topics: Animals; Anticonvulsants; Biotransformation; Drug Evaluation, Preclinical; Epilepsy; Fatty Acids, Monounsaturated; Prodrugs; Random Allocation; Stereoisomerism; Structure-Activity Relationship; Valproic Acid	1994
New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet? Current opinion in neurology, 2003, Volume: 16, Issue:2 Topics: Amides; Anticonvulsants; Bipolar Disorder; Epilepsy; Humans; Migraine Disorders; Valproic Acid	2003
[Lower limb edema during valpromide treatment: case report and literature review]. La Revue de medecine interne, 2015, Volume: 36, Issue:10 Topics: Aged, 80 and over; Anticonvulsants; Edema; Female; Furosemide; Humans; Lower Extremity; Valproic Acid; Withholding Treatment	2015
Valproate, divalproex, valpromide: Are the differences in indications justified? Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158 Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid	2023

Trials

8 trial(s) available for valproic acid and dipropylacetamide

Article	Year
Valproic acid amide in the treatment of affective and schizoaffective disorders. Journal of affective disorders, 1984, Volume: 6, Issue:1 Topics: Adult; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; Drug Interactions; Humans; Middle Aged; Psychotic Disorders; Recurrence; Social Adjustment; Valproic Acid	1984
The antiepileptic properties of N-dipropylacetamide (depamide): a clinical trial. Acta neurologica, 1980, Volume: 2, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Valproic Acid	1980
Increased dipropylacetic acid bioavailability from dipropylacetamide by food. Epilepsia, 1982, Volume: 23, Issue:2 Topics: Absorption; Adult; Biological Availability; Digestive System; Eating; Fasting; Food; Humans; Kinetics; Male; Middle Aged; Valproic Acid	1982
[Comparison of valproate level in human plasma, cerebrospinal fluid and brain tissue following administration of various preparations of valproate and valpromide]. Praxis, 1994, Oct-04, Volume: 83, Issue:40 Topics: Adolescent; Adult; Anticonvulsants; Blood-Brain Barrier; Brain; Brain Chemistry; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Male; Valproic Acid	1994
Valpromide increases amplitude of heart rate circadian rhythm in remitted bipolar and unipolar disorders. A placebo-controlled study. European psychiatry : the journal of the Association of European Psychiatrists, 2000, Volume: 15, Issue:7 Topics: Adult; Anticonvulsants; Bipolar Disorder; Circadian Rhythm; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Female; Heart Rate; Humans; Male; Middle Aged; Recurrence; Sleep; Treatment Outcome; Valproic Acid	2000
Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data. Bipolar disorders, 2007, Volume: 9, Issue:6 Topics: Acetamides; Adult; Aged; Antimanic Agents; Bipolar Disorder; Depressive Disorder; Female; Humans; Lithium Compounds; Male; Middle Aged; Psychiatric Status Rating Scales; Time Factors; Treatment Outcome; Valproic Acid	2007
Treatment of endogenous depressions with valpromide (open study). Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems, 1991, Volume: 33, Issue:5-6 Topics: Adult; Aged; Anticonvulsants; Antimanic Agents; Depressive Disorder; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid	1991
[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2011, Volume: 31, Issue:6 Topics: Acupuncture Points; Acupuncture Therapy; Adolescent; Adult; Anticonvulsants; Catgut; Child; Child, Preschool; Combined Modality Therapy; Epilepsy; Female; Humans; Male; Middle Aged; Seizures; Valproic Acid; Young Adult	2011

Other Studies

105 other study(ies) available for valproic acid and dipropylacetamide

Article	Year
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants. Journal of medicinal chemistry, 1998, Jan-01, Volume: 41, Issue:1 Topics: 3-Mercaptopropionic Acid; Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Esters; Glycine; Male; Mice; Mice, Inbred Strains; Neurotoxins; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, Glycine; Seizures; Spinal Cord; Strychnine	1998
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship	2003
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22 Topics: Anticonvulsants; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Molecular Structure; Valproic Acid	2004
Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid. Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy, Complex Partial; Mice; Rats; Stereoisomerism; Structure-Activity Relationship; Urea; Valproic Acid	2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid. Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8 Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cyclopropanes; Epilepsy; Male; Mice; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Valproic Acid	2009
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. Journal of medicinal chemistry, 2009, Nov-26, Volume: 52, Issue:22 Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Spinal Nerves; Urea; Valproic Acid	2009
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Rapid quantitation of N-dipropylacetamide in human plasma by gas-liquid chromatography. Journal of chromatography, 1979, Jun-01, Volume: 174, Issue:1 Topics: Anticonvulsants; Chromatography, Gas; Humans; Methods; Valproic Acid	1979
[Clinical study of the normothymic effect of dipropylacetamide]. Acta psychiatrica Belgica, 1976, Volume: 76, Issue:3 Topics: Adolescent; Adult; Drug Evaluation; Female; Humans; Lithium; Male; Mental Disorders; Middle Aged; Psychotropic Drugs; Valerates; Valproic Acid	1976
Pharmacokinetic analysis of the structural requirements for forming "stable" analogues of valpromide. Pharmaceutical research, 1992, Volume: 9, Issue:8 Topics: Animals; Biotransformation; Chromatography, Gas; Dogs; Female; Half-Life; Magnetic Resonance Spectroscopy; Male; Protein Binding; Solubility; Stereoisomerism; Structure-Activity Relationship; Valproic Acid	1992
An improved gas chromatographic determination of valproic acid and valpromide in plasma. Pharmaceutica acta Helvetiae, 1992, Volume: 67, Issue:8 Topics: Adult; Anticonvulsants; Chromatography, Gas; Humans; Indicators and Reagents; Valproic Acid	1992
Comparison of valproate concentrations in human plasma, CSF and brain tissue after administration of different formulations of valproate or valpromide. Epilepsy research, 1991, Volume: 9, Issue:2 Topics: Adolescent; Adult; Brain; Electroencephalography; Female; Humans; Male; Seizures; Valproic Acid	1991
Heterologous expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae. Study of the valpromide-carbamazepine epoxide interaction. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Base Sequence; Carbamazepine; Drug Interactions; Epoxide Hydrolases; Epoxy Compounds; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Microsomes; Molecular Sequence Data; Saccharomyces cerevisiae; Styrenes; Valproic Acid	1991
Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects. European journal of clinical pharmacology, 1990, Volume: 38, Issue:3 Topics: Adult; Amides; Half-Life; Humans; Isomerism; Male; Valproic Acid	1990
GABA mimetics decrease extracellular concentrations of 5-HIAA (as measured by in vivo voltammetry) in the dorsal raphe of the rat. Brain research, 1985, Aug-26, Volume: 341, Issue:2 Topics: Animals; Brain Stem; Corpus Striatum; Electrochemistry; gamma-Aminobutyric Acid; Hydroxyindoleacetic Acid; Male; Raphe Nuclei; Rats; Rats, Inbred Strains; Valproic Acid	1985
Plasma level of dipropylacetamide and dipropylacetic acid and effect of these drugs on 5-hydroxytryptamine metabolism in mouse brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1986, Volume: 40, Issue:5 Topics: Animals; Brain; Female; Hydroxyindoleacetic Acid; Mice; Serotonin; Valproic Acid	1986
Valpromide is a poor inhibitor of the cytosolic epoxide hydrolase. Archives of toxicology, 1989, Volume: 63, Issue:2 Topics: Anticonvulsants; Cytosol; Epoxide Hydrolases; Female; Fetus; Humans; In Vitro Techniques; Liver; Pregnancy; Stilbenes; Valproic Acid	1989
Inhibition of human liver microsomal epoxide hydrolase by valproate and valpromide: in vitro/in vivo correlation. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:1 Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epoxide Hydrolases; Epoxy Compounds; Humans; Hydrolysis; In Vitro Techniques; Male; Microsomes, Liver; Valproic Acid	1989
Structure-pharmacokinetic relationships in a series of valpromide derivatives with antiepileptic activity. Pharmaceutical research, 1989, Volume: 6, Issue:8 Topics: Acetamides; Allylisopropylacetamide; Animals; Anticonvulsants; Dogs; Drug Stability; Female; Male; Protein Binding; Solubility; Structure-Activity Relationship; Valproic Acid	1989
Inhibition of epoxide hydrolase by anticonvulsants and risk of teratogenicity. Lancet (London, England), 1989, Mar-18, Volume: 1, Issue:8638 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Interactions; Epoxide Hydrolases; Female; Humans; Infant, Newborn; Microsomes, Liver; Pregnancy; Valproic Acid	1989
Valpromide/carbamazepine and risk of teratogenicity. Lancet (London, England), 1985, Feb-16, Volume: 1, Issue:8425 Topics: Abnormalities, Drug-Induced; Animals; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant, Newborn; Macaca mulatta; Pregnancy; Valproic Acid	1985
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase]. Presse medicale (Paris, France : 1983), 1988, Nov-05, Volume: 17, Issue:39 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Edema; Carbamoyl-Phosphate Synthase (Ammonia); Humans; Male; Suicide, Attempted; Urea; Valproic Acid	1988
Valpromide inhibits human epoxide hydrolase. British journal of clinical pharmacology, 1986, Volume: 22, Issue:3 Topics: Adult; Aged; Anticonvulsants; Benzopyrenes; Epoxide Hydrolases; Epoxy Compounds; Female; Fetus; Humans; Intestines; Kidney; Lung; Male; Microsomes, Liver; Middle Aged; Valproic Acid	1986
[Determination of N-Dipropylacetamide serum concentration and its clinical significance in epileptic children]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1986, Volume: 19, Issue:4 Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Valproic Acid	1986
Computerized model for evaluating the kinetics of in vitro release of valpromide from controlled-release tablets under nonsink conditions. Journal of pharmaceutical sciences, 1986, Volume: 75, Issue:10 Topics: Biotransformation; Delayed-Action Preparations; Kinetics; Models, Biological; Valproic Acid	1986
Valpromide but not sodium hydrogen divalproate inhibits epoxide hydrolase in human liver. Pharmacology & toxicology, 1987, Volume: 60, Issue:3 Topics: Adult; Aged; Anticonvulsants; Epoxide Hydrolases; Humans; In Vitro Techniques; Liver; Microsomes, Liver; Middle Aged; Valproic Acid	1987
[Preventive effect of dipropylacetamide in bipolar manic-depressive psychoses]. Psychiatrie, Neurologie, und medizinische Psychologie, 1987, Volume: 39, Issue:6 Topics: Anticonvulsants; Bipolar Disorder; Humans; Valproic Acid	1987
[Personal experience with the prophylactic effect of dipropylacetamide]. Ceskoslovenska psychiatrie, 1988, Volume: 84, Issue:1 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Psychotic Disorders; Psychotropic Drugs; Schizophrenia; Valproic Acid	1988
Effect of valpromide on the pharmacokinetics of carbamazepine-10, 11-epoxide. British journal of clinical pharmacology, 1988, Volume: 25, Issue:5 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Female; Half-Life; Humans; Male; Middle Aged; Valproic Acid	1988
[Pharmacokinetic results of some antiepileptics]. Bollettino della Societa italiana di biologia sperimentale, 1988, Volume: 64, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Phenytoin; Valproic Acid	1988
Valpromide increases the plasma concentrations of amitriptyline and its metabolite nortriptyline in depressive patients. Therapeutic drug monitoring, 1988, Volume: 10, Issue:4 Topics: Adult; Amitriptyline; Anticonvulsants; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nortriptyline; Valproic Acid	1988
Pharmacokinetics of a valpromide isomer, valnoctamide, in dogs. Journal of pharmaceutical sciences, 1988, Volume: 77, Issue:10 Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Dogs; Female; Half-Life; Injections, Intravenous; Male; Protein Binding; Valproic Acid	1988
[Clinical and electroencephalographic study of the effects of valpramide in treating epilepsy]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1985, Volume: 18, Issue:3 Topics: Adolescent; Adult; Anticonvulsants; Child; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid	1985
A study on the metabolism of dipropylacetamide to dipropylacetic acid in rats. The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:1 Topics: Animals; Biotransformation; Digestive System; Intestines; Male; Neomycin; Rats; Rats, Inbred Strains; Valproic Acid	1982
A comparative study on the pharmacokinetics of valpramide after intravenous administration in dogs. The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:9 Topics: Animals; Biotransformation; Dogs; Female; Injections, Intravenous; Kinetics; Male; Valproic Acid	1983
Possible hazard of valpromide-carbamazepine combination therapy in epilepsy. Lancet (London, England), 1984, Apr-07, Volume: 1, Issue:8380 Topics: Anticonvulsants; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid	1984
EEG and anticonvulsant effects of dipropylacetic acid and dipropylacetamide in the baboon Papio papio. Electroencephalography and clinical neurophysiology, 1980, Volume: 49, Issue:3-4 Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Female; Male; Papio; Seizures; Valproic Acid	1980
Effect of the antiepileptic di-n-propylacetamide on 5-hydroxytryptamine turnover in the brain and 5-hydroxyindoleacetic acid level in the cerebrospinal fluid. European journal of pharmacology, 1983, Jul-15, Volume: 91, Issue:1 Topics: Animals; Brain Chemistry; Cats; Female; Hydroxyindoleacetic Acid; Male; Rats; Rats, Inbred Strains; Serotonin; Time Factors; Valproic Acid	1983
Lack of cross-reactivity between EMIT valproic acid assay and N-dipropylacetamide. Therapeutic drug monitoring, 1983, Volume: 5, Issue:1 Topics: Cross Reactions; Humans; Immunoenzyme Techniques; Valproic Acid	1983
[Prevention of phases in manic-depressive disorder with dipropylacetamide (Depamide)]. Ceskoslovenska psychiatrie, 1983, Volume: 79, Issue:3 Topics: Adult; Bipolar Disorder; Female; Humans; Male; Valproic Acid	1983
Intra-daily oscillations in dipropylacetic acid plasma levels with two or three daily doses of dipropylacetamide in epileptic patients. Italian journal of neurological sciences, 1983, Volume: 4, Issue:2 Topics: Adolescent; Adult; Child; Circadian Rhythm; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Valproic Acid	1983
[Comparison of the side-effects of lithium and dipropylacetamide (Depamide)]. Ceskoslovenska psychiatrie, 1983, Volume: 79, Issue:4 Topics: Humans; Lithium; Valproic Acid	1983
Valproic acid amide as a prophylactic agent in affective and schizoaffective disorders. Psychopharmacology bulletin, 1984,Winter, Volume: 20, Issue:1 Topics: Adult; Bipolar Disorder; Humans; Middle Aged; Mood Disorders; Psychotic Disorders; Recurrence; Valproic Acid	1984
Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities. Neurochemical research, 1984, Volume: 9, Issue:2 Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Male; Mice; Oxidoreductases; Phenobarbital; Phenytoin; Valproic Acid	1984
Effects of valproic acid derivatives on the acquisition of active avoidance behavior in the rat. Pharmacological research communications, 1984, Volume: 16, Issue:7 Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Male; Motor Activity; Rats; Rats, Inbred Strains; Valproic Acid	1984
Gabaergic modulation of mouse-killing in the rat. Psychopharmacology, 1984, Volume: 83, Issue:4 Topics: Aggression; Aminocaproates; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Motor Activity; Nipecotic Acids; Picrotoxin; Rats; Rats, Inbred Strains; Valproic Acid; Vigabatrin	1984
Pharmacokinetics of valpromide after oral administration of a solution and a tablet to healthy volunteers. European journal of clinical pharmacology, 1984, Volume: 27, Issue:4 Topics: Adult; Humans; Kinetics; Male; Solutions; Tablets; Time Factors; Valproic Acid	1984
[Hydrolysis of valproamide to valproic acid]. Die Pharmazie, 1984, Volume: 39, Issue:12 Topics: Animals; Chemical Phenomena; Chemistry; Drug Stability; Humans; Hydrolysis; In Vitro Techniques; Liver; Rats; Valproic Acid	1984
The effect of chronic N-dipropylacetamide ("depamide") treatment on plasmatic immunoglobulins of epileptic patients. Acta neurologica, 1980, Volume: 2, Issue:2 Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Male; Valproic Acid	1980
Increase in striatal acetylcholine levels by GABAergic agents: dependence on corticostriatal neurons. Brain research, 1980, Oct-27, Volume: 200, Issue:1 Topics: Acetylcholine; Animals; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Muscimol; Neurons; Rats; Valproic Acid	1980
Preliminary data on dipropylacetamide absorption in rats. Bollettino della Societa italiana di biologia sperimentale, 1980, Aug-15, Volume: 56, Issue:15 Topics: Absorption; Administration, Oral; Animals; Injections, Intramuscular; Male; Neomycin; Rats; Valproic Acid	1980
[A neuro-immunological hypothesis for some forms of epilepsy]. Acta neurologica, 1981, Volume: 3, Issue:1 Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Humans; Hydantoins; Immunoglobulins; Immunologic Deficiency Syndromes; Leukocyte Count; T-Lymphocytes; Valproic Acid	1981
[The use of dipropylacetamide in antiepileptic therapy. Pharmacological and clinical aspects]. Acta neurologica, 1981, Volume: 3, Issue:1 Topics: Epilepsy; Humans; Valproic Acid	1981
[The use of dipropylacetamide in anti-epileptic therapy. Pharmacological and clinical aspects]. Acta neurologica. Quaderni, 1981, Volume: 42 Topics: Epilepsy; Humans; Valproic Acid	1981
Depamide: a preliminary report on its therapeutic efficacy in epilepsy. Monographs in neural sciences, 1980, Volume: 5 Topics: Adolescent; Adult; Anticonvulsants; Behavior; Child; Drug Evaluation; Drug Interactions; Electroencephalography; Epilepsy; Female; Humans; Male; Valproic Acid	1980
Dipropylacetic acid plasma levels; diurnal fluctuations during chronic treatment with dipropylacetamide. Therapeutic drug monitoring, 1981, Volume: 3, Issue:3 Topics: Adolescent; Adult; Anticonvulsants; Child; Circadian Rhythm; Epilepsy; Humans; Valproic Acid	1981
Some clinical pharmacological aspects of n-dipropylacetamide. Italian journal of neurological sciences, 1980, Volume: 1, Issue:4 Topics: Adult; Anticonvulsants; Female; Humans; Kinetics; Male; Time Factors; Valproic Acid	1980
[Dipropylacetamide and hypnosis in drug dependence]. Minerva medica, 1982, Mar-31, Volume: 73, Issue:13 Topics: Adult; Female; Heroin Dependence; Humans; Hypnosis; Physician-Patient Relations; Substance Withdrawal Syndrome; Transfer, Psychology; Valproic Acid	1982
Quantitative determination of n-dipropylacetamide in the plasma of epileptic patients by gas--liquid chromatography with nitrogen-selective detection. Journal of chromatography, 1982, Dec-10, Volume: 233 Topics: Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Nitrogen; Valproic Acid	1982
Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine. Pharmaceutical research, 1995, Volume: 12, Issue:6 Topics: Animals; Anticonvulsants; Dogs; Female; gamma-Aminobutyric Acid; Glycine; Injections, Intravenous; Male; Time Factors; Valproic Acid	1995
Saccharomyces cerevisiae: an alternative source for human microsomal liver enzymes and its use in drug interaction studies. Toxicology, 1993, Oct-05, Volume: 82, Issue:1-3 Topics: Anticonvulsants; Benzoflavones; Carbamazepine; Cloning, Molecular; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Epoxide Hydrolases; Humans; Ketoconazole; Microsomes, Liver; Oxidoreductases, N-Demethylating; Saccharomyces cerevisiae; Valproic Acid	1993
Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of rats. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:5 Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Liver; Male; Rats; Tissue Distribution; Valproic Acid	1996
Pharmacokinetic analysis and antiepileptic activity of tetra-methylcyclopropane analogues of valpromide. Pharmaceutical research, 1996, Volume: 13, Issue:2 Topics: Animals; Anticonvulsants; Cyclopropanes; Dogs; Drug Stability; Hydrolysis; Mice; Structure-Activity Relationship; Valproic Acid	1996
Pharmacokinetics and antiepileptic activity of valproyl hydroxamic acid derivatives. Pharmaceutical research, 1997, Volume: 14, Issue:2 Topics: Animals; Anticonvulsants; Biotransformation; Dogs; Hydroxamic Acids; Mice; Rats; Structure-Activity Relationship; Valproic Acid	1997
Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid. Epilepsy research, 1998, Volume: 30, Issue:1 Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Body Weight; Embryo, Mammalian; Female; Fetal Death; Mice; Mice, Inbred Strains; Pentanoic Acids; Pregnancy; Teratogens; Valproic Acid	1998
Effects of new valproate derivatives on epileptiform discharges induced by pentylenetetrazole or low Mg2+ in rat entorhinal cortex-hippocampus slices. Epilepsy research, 1998, Volume: 32, Issue:3 Topics: Animals; Anticonvulsants; Convulsants; Entorhinal Cortex; Epilepsy; Female; Glucose; Hippocampus; In Vitro Techniques; Magnesium; Male; Pentylenetetrazole; Rats; Rats, Wistar; Structure-Activity Relationship; Valproic Acid; Xylitol	1998
Pharmacokinetic considerations in the design of better and safer new antiepileptic drugs. Journal of controlled release : official journal of the Controlled Release Society, 1999, Nov-01, Volume: 62, Issue:1-2 Topics: Amides; Animals; Anticonvulsants; Biotransformation; Cyclopropanes; Dogs; Drug Design; Glycine; Mice; Rats; Rats, Sprague-Dawley; Valproic Acid	1999
Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid. Pharmaceutical research, 2000, Volume: 17, Issue:2 Topics: Amides; Anti-Anxiety Agents; Anticonvulsants; Epoxide Hydrolases; Ethylene Glycols; Humans; Isomerism; Liver; Microsomes; Structure-Activity Relationship; Valproic Acid	2000
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy. Pharmaceutical research, 2000, Volume: 17, Issue:11 Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Valproic Acid	2000
Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide. Therapeutic drug monitoring, 2001, Volume: 23, Issue:4 Topics: Animals; Anticonvulsants; Brain; Dogs; Drug Evaluation, Preclinical; Rats; Rats, Sprague-Dawley; Seizures; Stereoisomerism; Valproic Acid	2001
[Manic syndrome: diagnostic trends and principles of treatment]. La Revue du praticien, 1998, Apr-01, Volume: 48, Issue:7 Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Chlorpromazine; Diagnosis, Differential; Haloperidol; Hospitalization; Humans; Iatrogenic Disease; Lithium; Neurocognitive Disorders; Schizophrenia; Syndrome; Time Factors; Valproic Acid	1998
On the epigenetic regulation of the human reelin promoter. Nucleic acids research, 2002, Jul-01, Volume: 30, Issue:13 Topics: Base Sequence; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Line; Chromatin; Deoxycytosine Nucleotides; DNA Methylation; Extracellular Matrix Proteins; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Luciferases; Molecular Sequence Data; Nerve Tissue Proteins; Promoter Regions, Genetic; Recombinant Fusion Proteins; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Tretinoin; Tumor Cells, Cultured; Valproic Acid	2002
Lupus-like syndrome and vasculitis induced by valpromide. The Journal of rheumatology, 2003, Volume: 30, Issue:1 Topics: Adult; Anticonvulsants; Female; Humans; Lupus Nephritis; Male; Middle Aged; Valproic Acid; Vasculitis	2003
Mood-stabilizers: the archeology of the concept. Bipolar disorders, 2003, Volume: 5, Issue:6 Topics: Affect; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Concept Formation; Forecasting; History, 20th Century; History, 21st Century; Humans; Lithium Carbonate; Mood Disorders; Psychotropic Drugs; Valproic Acid	2003
Amidic modification of valproic acid reduces skeletal teratogenicity in mice. Birth defects research. Part B, Developmental and reproductive toxicology, 2004, Volume: 71, Issue:1 Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Bone and Bones; Cartilage; Cesarean Section; Female; Fetus; Male; Mice; Molecular Structure; Neural Tube Defects; Valproic Acid	2004
Delayed toxicity following acute ingestion of valpromide. Human & experimental toxicology, 2004, Volume: 23, Issue:3 Topics: Adult; Anticonvulsants; Coma; Dyspnea; Female; Hepatic Encephalopathy; Humans; Male; Prodrugs; Time Factors; Valproic Acid	2004
Characterization of the anticonvulsant profile of valpromide derivatives. Bioorganic & medicinal chemistry, 2004, Jul-15, Volume: 12, Issue:14 Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Valproic Acid	2004
[Deep lactic acidosis after valproate self-poisoning]. Annales francaises d'anesthesie et de reanimation, 2004, Volume: 23, Issue:10 Topics: Anticonvulsants; Female; Glasgow Coma Scale; Hemodiafiltration; Humans; Infusions, Intravenous; Middle Aged; Sodium Bicarbonate; Suicide, Attempted; Treatment Outcome; Valproic Acid	2004
Polycomb homologs are involved in teratogenicity of valproic acid in mice. Birth defects research. Part A, Clinical and molecular teratology, 2004, Volume: 70, Issue:11 Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Bone and Bones; DNA-Binding Proteins; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Gene Silencing; Histone-Lysine N-Methyltransferase; Injections, Subcutaneous; Male; Mice; Myeloid-Lymphoid Leukemia Protein; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Pregnancy; Proto-Oncogenes; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Valproic Acid; Zinc Fingers	2004
Valproate decreases inositol biosynthesis. Biological psychiatry, 2004, Dec-01, Volume: 56, Issue:11 Topics: Amides; Animals; Animals, Newborn; Anticonvulsants; Blotting, Northern; Brain Chemistry; Cells, Cultured; Chromatography, Gas; Cyclopropanes; Dose-Response Relationship, Drug; Ganglia, Spinal; Gene Expression; Humans; In Vitro Techniques; Inositol; Male; Mice; Mice, Inbred ICR; Myo-Inositol-1-Phosphate Synthase; Neurons; Postmortem Changes; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Valproic Acid	2004
Mood stabilizer augmentation in apparently "unipolar" MDD: predictors of response in the naturalistic French national EPIDEP study. Journal of affective disorders, 2005, Volume: 84, Issue:2-3 Topics: Adult; Anticonvulsants; Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Carbamazepine; Depressive Disorder, Major; Diagnosis, Differential; Drug Therapy, Combination; Female; France; Humans; Lithium Carbonate; Male; Middle Aged; Personality Inventory; Prognosis; Recurrence; Retrospective Studies; Treatment Outcome; Valproic Acid	2005
The role of histone acetylation in SMN gene expression. Human molecular genetics, 2005, May-01, Volume: 14, Issue:9 Topics: Acetylation; Animals; Cells, Cultured; Chromatin Immunoprecipitation; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Epigenesis, Genetic; Fibroblasts; Gene Dosage; Gene Expression; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histones; Humans; Hybridomas; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Muscular Atrophy, Spinal; Nerve Tissue Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA-Binding Proteins; SMN Complex Proteins; Survival of Motor Neuron 2 Protein; Transcription, Genetic; Valproic Acid; Vorinostat	2005
Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice. Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:4 Topics: Abnormalities, Drug-Induced; Amides; Animals; Embryo, Mammalian; Female; Gene Expression; Gene Expression Profiling; Immediate-Early Proteins; Mice; Neural Tube Defects; Oligonucleotide Array Sequence Analysis; Pregnancy; Valproic Acid	2005
Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain. British journal of pharmacology, 2005, Volume: 146, Issue:2 Topics: Analgesics; Animals; Anticonvulsants; Hyperalgesia; Isomerism; Ligation; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Spinal Nerves; Structure-Activity Relationship; Valproic Acid	2005
Catalytic mechanism of limonene epoxide hydrolase, a theoretical study. Journal of the American Chemical Society, 2005, Oct-19, Volume: 127, Issue:41 Topics: Bacterial Proteins; Catalysis; Crystallography, X-Ray; Cyclohexane Monoterpenes; Epoxide Hydrolases; Hydrogen Bonding; Hydrolysis; Models, Theoretical; Molecular Structure; Monoterpenes; Protein Conformation; Protein Structure, Tertiary; Stereoisomerism; Structure-Activity Relationship; Valproic Acid	2005
Management of epilepsy in adults. Diagnosis guidelines. Postgraduate medicine, 2005, Volume: 118, Issue:6 Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Child; Diagnosis, Differential; Electroencephalography; Epilepsy; Humans; Magnetic Resonance Imaging; Myoclonic Epilepsy, Juvenile; Primary Health Care; Valproic Acid	2005
The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Molecular pharmacology, 2007, Volume: 71, Issue:3 Topics: Animals; Anticonvulsants; Cells, Cultured; Dictyostelium; Ganglia, Spinal; Growth Cones; Inositol 1,4,5-Trisphosphate; Rats; Rats, Sprague-Dawley; Signal Transduction; Valproic Acid; Wnt Proteins	2007
Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. British journal of pharmacology, 2008, Volume: 153, Issue:4 Topics: Acetylation; Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Butyrates; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Lysine; Neuroblastoma; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Signal Transduction; Transfection; Tumor Suppressor Protein p53; Up-Regulation; Valproic Acid	2008
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells. Neurochemical research, 2008, Volume: 33, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Melatonin; Mice; Neuroblastoma; Neurofilament Proteins; Valproic Acid	2008
Alternative therapeutic approaches to the treatment of acute phases of endogenous psychoses. Homeostasis in health and disease : international journal devoted to integrative brain functions and homeostatic systems, 1991, Volume: 33, Issue:5-6 Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Carbamazepine; Humans; Hypnotics and Sedatives; Psychiatric Status Rating Scales; Psychotic Disorders; Valproic Acid	1991
Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. Journal of neurochemistry, 2009, Volume: 111, Issue:4 Topics: Acetylation; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Histone Deacetylase 1; Histone Deacetylases; HSP70 Heat-Shock Proteins; Immunoglobulins; Neurons; Rats; Tetrazolium Salts; Thiazoles; Time Factors; Valproic Acid	2009
Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 131, Issue:1 Topics: Animals; Blotting, Western; Cells, Cultured; Chondrogenesis; Core Binding Factor Alpha 1 Subunit; Dose-Response Relationship, Drug; Female; Forelimb; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histone Deacetylases; Limb Buds; Limb Deformities, Congenital; Mice; Mice, Inbred Strains; Organogenesis; Osteogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Real-Time Polymerase Chain Reaction; SOXB1 Transcription Factors; Valproic Acid	2013
Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition. Journal of cellular biochemistry, 2013, Volume: 114, Issue:4 Topics: Antineoplastic Agents; Apoptosis; Benzamides; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Inhibitor of Apoptosis Proteins; Isoenzymes; Neuroblastoma; Proteolysis; Proto-Oncogene Proteins c-akt; Pyridines; Staurosporine; Survivin; Valproic Acid	2013
Synthesis, characterization, and in vitro evaluation of new coordination complexes of platinum(II) and rhenium(I) with a ligand targeting the translocator protein (TSPO). Dalton transactions (Cambridge, England : 2003), 2014, Nov-21, Volume: 43, Issue:43 Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Coordination Complexes; Humans; Ligands; Microscopy, Fluorescence; Mitochondria; Platinum; Protein Binding; Receptors, GABA; Rhenium; Valproic Acid	2014
Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs. Birth defects research. Part B, Developmental and reproductive toxicology, 2015, Volume: 104, Issue:5 Topics: Acetylation; Animals; Apoptosis; Biomarkers; Caspase 3; Caspase 9; Extremities; Female; Gene Expression Regulation, Developmental; Histones; Mice; Organogenesis; Phosphorylation; Poly(ADP-ribose) Polymerases; Tumor Suppressor Protein p53; Valproic Acid	2015
Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus. mBio, 2016, Mar-01, Volume: 7, Issue:2 Topics: Antiviral Agents; B-Lymphocytes; Cell Line; Gene Expression; Herpesvirus 4, Human; Humans; Immediate-Early Proteins; Trans-Activators; Valproic Acid; Virus Activation	2016
Mood stabilizers inhibit cytomegalovirus infection. Virology, 2016, Volume: 499 Topics: Amides; Animals; Cell Line; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Disease Models, Animal; Female; Humans; Male; Mice; Muromegalovirus; Tranquilizing Agents; Valproic Acid; Viral Load; Virus Replication	2016
Structural insights into human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations. Proteins, 2017, Volume: 85, Issue:4 Topics: Amino Acid Sequence; Aspergillus niger; Catalytic Domain; Conserved Sequence; Enzyme Inhibitors; Epoxide Hydrolases; Epoxy Compounds; Humans; Kinetics; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Sequence Alignment; Streptomyces; Structural Homology, Protein; Substrate Specificity; Valproic Acid	2017
In utero drug exposure and hearing impairment in 2-year-old children A case-control study using the EFEMERIS database. International journal of pediatric otorhinolaryngology, 2018, Volume: 113 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Aspirin; Case-Control Studies; Child, Preschool; Databases, Factual; Female; France; Glucocorticoids; Hearing Loss; Humans; Male; Otitis Media; Pregnancy; Prenatal Exposure Delayed Effects; Valproic Acid	2018
Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes. Antiviral research, 2019, Volume: 168 Topics: Amides; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Herpesvirus 1, Human; Humans; Molecular Structure; Oligodendroglia; Rats; Valproic Acid; Viral Proteins; Virus Internalization; Virus Replication	2019
Vanishing White Matter Hyperintensities in CADASIL: A Case Report with Insight into Disease Mechanisms. Journal of Alzheimer's disease : JAD, 2020, Volume: 78, Issue:3 Topics: Antimanic Agents; Bipolar Disorder; Brain; CADASIL; Disease Progression; Drug Substitution; Female; Humans; Imaging, Three-Dimensional; Leukoencephalopathies; Lithium Compounds; Magnetic Resonance Imaging; Middle Aged; Organ Size; Temporal Lobe; Valproic Acid	2020
Delayed and prolonged coma following valpromide poisoning in a 4-year-old girl. Clinical toxicology (Philadelphia, Pa.), 2021, Volume: 59, Issue:8 Topics: Anticonvulsants; Child, Preschool; Coma; Drug Overdose; Female; Humans; Intubation; Valproic Acid	2021
The Valproic Acid Derivative Valpromide Inhibits Pseudorabies Virus Infection in Swine Epithelial and Mouse Neuroblastoma Cell Lines. Viruses, 2021, 12-15, Volume: 13, Issue:12 Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Herpesvirus 1, Suid; Mice; Neuroblastoma; Pseudorabies; Swine; Swine Diseases; Valproic Acid	2021