valproic acid has been researched along with coenzyme a in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 12 (57.14) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Baillie, TA | 1 |
| Hauhart, RE; Thurston, JH | 2 |
| Ponchaut, S; van Hoof, F; Veitch, K | 1 |
| Baverel, G; Durozard, D; Martin, G | 1 |
| Frerman, F; Luder, AS; Parker, WD; Parks, JK | 1 |
| Harris, RA; Swartzentruber, MS | 1 |
| Carroll, JE; Hauhart, RE; Schiro, JA; Thurston, JH | 1 |
| Baillie, TA; Bjorge, SM | 1 |
| Becker, CM; Harris, RA | 1 |
| Mortensen, PB | 1 |
| Krähenbühl, S; Krause, M; Kupferschmidt, H; Mang, G; Meier, PJ | 1 |
| Odle, J; van Kempen, TA | 1 |
| Luo, MJ; Mao, LF; Schulz, H; Yao, KW | 1 |
| Baillie, TA; Davis, MR; Grillo, MP; Hu, P; Jin, L; Kassahun, K | 1 |
| Adams, SH; Lin, X; Odle, J | 1 |
| Bock, I; Cseko, J; Farkas, V; Sandor, A | 1 |
| Deutsch, J; Rapoport, SI; Rosenberger, TA | 1 |
| Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Luís, PB; Ruiter, JP; Silva, MF; ten Brink, HJ; Wanders, RJ | 1 |
| Aires, CC; de Almeida, IT; Duran, M; Luís, PB; Silva, MF; Soveral, G; ten Brink, HJ; Wanders, RJ | 1 |
| Ezhilarasan, D; Mani, U | 1 |
3 review(s) available for valproic acid and coenzyme a
| Article | Year |
|---|---|
Metabolism of valproate to hepatotoxic intermediates.
Topics: Animals; Biotransformation; Coenzyme A; Cytochrome P-450 Enzyme System; Fatty Acids, Monounsaturated; Humans; Liver; Mitochondria, Liver; Rats; Valproic Acid | 1992 |
Dicarboxylic acids and the lipid metabolism.
Topics: Acyl Coenzyme A; Animals; Carboxylic Acids; Carnitine O-Acetyltransferase; Coenzyme A; Dicarboxylic Acids; Fatty Acids; Gas Chromatography-Mass Spectrometry; Hormones; Humans; Hydroxylation; Ketosis; Lipase; Lipid Metabolism; Lipid Metabolism, Inborn Errors; Microbodies; Oxidation-Reduction; Rats; Valproic Acid | 1984 |
Valproic acid induced liver injury: An insight into molecular toxicological mechanism.
Topics: Adenosine Triphosphate; Ammonia; Anticonvulsants; Carnitine O-Palmitoyltransferase; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Coenzyme A; DNA, Mitochondrial; Glutathione; Humans; Liver; Peroxisome Proliferator-Activated Receptors; Protons; Transaminases; Triglycerides; Valproic Acid | 2022 |
18 other study(ies) available for valproic acid and coenzyme a
| Article | Year |
|---|---|
Amelioration of adverse effects of valproic acid on ketogenesis and liver coenzyme A metabolism by cotreatment with pantothenate and carnitine in developing mice: possible clinical significance.
Topics: Animals; Animals, Suckling; Carnitine; Coenzyme A; Cysteine; Ketone Bodies; Liver; Mice; Pantothenic Acid; Valproic Acid | 1992 |
In vitro effects of valproate and valproate metabolites on mitochondrial oxidations. Relevance of CoA sequestration to the observed inhibitions.
Topics: Animals; Coenzyme A; Coenzyme A Ligases; Fatty Acids; Male; Mitochondria, Liver; Models, Chemical; Oxygen Consumption; Rats; Rats, Inbred Strains; Repressor Proteins; Saccharomyces cerevisiae Proteins; Valproic Acid | 1992 |
Valproate-induced alterations of coenzyme A and coenzyme A ester concentrations in human kidney tubules metabolizing glutamine.
Topics: Acetyl Coenzyme A; Adult; Ammonia; Coenzyme A; Glutamine; Humans; In Vitro Techniques; Kidney Tubules; Valproic Acid | 1991 |
Inactivation of beef brain alpha-ketoglutarate dehydrogenase complex by valproic acid and valproic acid metabolites. Possible mechanism of anticonvulsant and toxic actions.
Topics: Animals; Anticonvulsants; Brain; Cattle; Coenzyme A; Fatty Acids, Monounsaturated; Ketoglutarate Dehydrogenase Complex; Kinetics; NAD; Spectrum Analysis; Valproic Acid | 1990 |
Inhibition of metabolic processes by coenzyme-A-sequestering aromatic acids. Prevention by para-chloro- and para-nitrobenzoic acids.
Topics: 4-Aminobenzoic Acid; Ammonia; Animals; Benzoates; Benzoic Acid; Coenzyme A; Fatty Acids; Glucose; In Vitro Techniques; Liver; Male; Nitrobenzoates; Rats; Salicylates; Salicylic Acid; Valproic Acid | 1987 |
A single therapeutic dose of valproate affects liver carbohydrate, fat, adenylate, amino acid, coenzyme A, and carnitine metabolism in infant mice: possible clinical significance.
Topics: 3-Hydroxybutyric Acid; Adenosine Monophosphate; Amino Acids; Animal Population Groups; Animals; Animals, Suckling; Carbohydrate Metabolism; Carnitine; Coenzyme A; Energy Metabolism; Fatty Acids, Nonesterified; Hydroxybutyrates; Ketone Bodies; Lipid Metabolism; Liver; Mice; Valproic Acid | 1985 |
Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid.
Topics: Adenosine Triphosphate; Animals; Caproates; Caprylates; Coenzyme A; Decanoic Acids; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Liver; Rats; Valproic Acid | 1985 |
Influence of valproic acid on hepatic carbohydrate and lipid metabolism.
Topics: Acyltransferases; Animals; Caprylates; Carbohydrate Metabolism; Carnitine Acyltransferases; Coenzyme A; Fatty Acids; Female; Gluconeogenesis; Ketone Bodies; Lipid Metabolism; Liver; Mitochondria, Liver; Oleic Acid; Oleic Acids; Oxygen Consumption; Rats; Salicylates; Salicylic Acid; Valproic Acid | 1983 |
Plasma and hepatic carnitine and coenzyme A pools in a patient with fatal, valproate induced hepatotoxicity.
Topics: Adult; Carnitine; Chemical and Drug Induced Liver Injury; Coenzyme A; Fatal Outcome; Female; Humans; Liver; Valproic Acid | 1995 |
Carnitine affects octanoate oxidation to carbon dioxide and dicarboxylic acids in colostrum-deprived piglets: in vivo analysis of mechanisms involved based on CoA- and carnitine-ester profiles.
Topics: Animals; Animals, Newborn; Caprylates; Carbon Dioxide; Carnitine; Chromatography, High Pressure Liquid; Coenzyme A; Colostrum; Dicarboxylic Acids; Female; Infusions, Intra-Arterial; Liver; Muscles; Oxidation-Reduction; Pregnancy; Swine; Time Factors; Valproic Acid | 1995 |
The relationship between mitochondrial activation and toxicity of some substituted carboxylic acids.
Topics: Animals; Carboxylic Acids; Chromatography, High Pressure Liquid; Coenzyme A; Crotonates; Dose-Response Relationship, Drug; Epoxy Compounds; Fatty Acids; Fatty Acids, Monounsaturated; Mitochondria, Heart; Mitochondria, Liver; Oxidation-Reduction; Oxygen Consumption; Palmitoylcarnitine; Rats; Spectrophotometry, Ultraviolet; Valproic Acid; Xenobiotics | 1994 |
Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
Topics: Acetylcysteine; Animals; Biotransformation; Chromatography, Liquid; Coenzyme A; Fatty Acids, Monounsaturated; Glutathione; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Triglycerides; Valproic Acid | 1994 |
Comparative effects of valproate and the new experimental anticonvulsant drug alpha-ethyl-alpha-methyl-thiobutyrolactone on selected metabolite levels in the plasma, livers, and brains of infant mice.
Topics: 3-Hydroxybutyric Acid; 4-Butyrolactone; Amino Acids; Animals; Animals, Suckling; Anticonvulsants; Blood Glucose; Brain Chemistry; Carnitine; Coenzyme A; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Hydroxybutyrates; Liver; Mice; Valproic Acid | 1996 |
Acetate represents a major product of heptanoate and octanoate beta-oxidation in hepatocytes isolated from neonatal piglets.
Topics: Acetates; Acetyl Coenzyme A; Animals; Animals, Newborn; Caprylates; Carbon Dioxide; Carnitine; Chromatography, High Pressure Liquid; Coenzyme A; Diet; Fatty Acids; Heptanoic Acids; Liver; Malonates; Oxidation-Reduction; Oxygen Consumption; Swine; Valproic Acid | 1996 |
Inhibition of carnitine biosynthesis by valproic acid in rats--the biochemical mechanism of inhibition.
Topics: Acetyl Coenzyme A; Animals; Anticonvulsants; Betaine; Carnitine; Coenzyme A; Glutamic Acid; Humans; Ketoglutaric Acids; Liver; Male; Rats; Rats, Wistar; Valproic Acid | 1996 |
Valproyl-CoA and esterified valproic acid are not found in brains of rats treated with valproic acid, but the brain concentrations of CoA and acetyl-CoA are altered.
Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Animals; Brain; Chromatography, Gas; Coenzyme A; Esters; Fatty Acids; Kinetics; Male; Methylation; Rats; Rats, Inbred F344; Valproic Acid | 2003 |
Studies on the extra-mitochondrial CoA -ester formation of valproic and Delta4 -valproic acids.
Topics: Acyl Coenzyme A; Animals; Chromatography, High Pressure Liquid; Citrate (si)-Synthase; Coenzyme A; Cytosol; Esters; Hepatocytes; Hydrogen-Ion Concentration; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Wistar; Reference Standards; Time Factors; Valproic Acid | 2007 |
Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes.
Topics: Animals; Anticonvulsants; Biological Transport; Coenzyme A; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Liver; Male; Mitochondria, Liver; Mitochondrial Membranes; Oxidative Phosphorylation; Pyruvic Acid; Rats; Rats, Wistar; Valproic Acid | 2008 |