valproic acid has been researched along with clofibrate in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Jones, LH; Nadanaciva, S; Rana, P; Will, Y | 1 |
| Keller, BJ; Thurman, RG; Yamanaka, H | 1 |
| Draye, JP; Ponchaut, S; Van Hoof, F; Veitch, K | 1 |
| Draye, JP; Vamecq, J | 1 |
| Bachmann, KA; Jahn, D; Schwartz, J; Yang, C | 1 |
| Heinemeyer, G; Hildebrandt, AG; Nau, H; Roots, I | 1 |
| Fontaine, M; Lambert, D; Nuyts, JP; Poupaert, J; Vallee, L; Vamecq, J | 1 |
| Chen, P; Colet, JM; Estrem, ST; Gao, H; Goldstein, KM; Huang, S; Jolly, RA; Ryan, TP; Thomas, CE; Wei, T | 1 |
| Balasubramanian, KA; Eapen, CE; Natarajan, SK; Pullimood, AB | 1 |
| Aleksunes, LM; Corton, JC; George, MH; Klaassen, CD; Ren, H; Vallanat, B; Wood, C | 1 |
3 review(s) available for valproic acid and clofibrate
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor.
Topics: Animals; Clofibrate; Constitutive Androstane Receptor; Diethylhexyl Phthalate; Gene Expression Profiling; Gene Expression Regulation; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Peroxisome Proliferators; Phenobarbital; Plasticizers; PPAR alpha; Pregnane X Receptor; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Valproic Acid | 2010 |
16 other study(ies) available for valproic acid and clofibrate
| Article | Year |
|---|---|
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Inhibition of mitochondrial respiration and oxygen-dependent hepatotoxicity by six structurally dissimilar peroxisomal proliferating agents.
Topics: Animals; Aspirin; Cell Division; Clofibrate; Clofibric Acid; Dose-Response Relationship, Drug; Female; Fibric Acids; Hypolipidemic Agents; L-Lactate Dehydrogenase; Microbodies; Mitochondria, Liver; Oxygen Consumption; Rats; Rats, Inbred Strains; Trypan Blue; Valproic Acid | 1992 |
Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney. Oxidation of valproate by liver peroxisomes.
Topics: Animals; Clofibrate; Electrophoresis, Polyacrylamide Gel; Kidney; Liver; Male; Microbodies; Oxidation-Reduction; Peptides; Rats; Rats, Inbred Strains; Valproic Acid | 1991 |
The inhibition by valproic acid of the mitochondrial oxidation of monocarboxylic and omega-hydroxymonocarboxylic acids: possible implications for the metabolism of gamma-aminobutyric acid.
Topics: Animals; Carboxylic Acids; Clofibrate; gamma-Aminobutyric Acid; Kinetics; Liver; Male; Microbodies; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Valproic Acid | 1987 |
The use of single sample clearance estimates to probe hepatic drug metabolism in rats. II.
Topics: Animals; Antipyrine; Benzoflavones; beta-Naphthoflavone; Clofibrate; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Phenobarbital; Rats; Rats, Inbred Strains; Safrole; Theophylline; Valproic Acid; Warfarin | 1988 |
Oxidation and glucuronidation of valproic acid in male rats--influence of phenobarbital, 3-methylcholanthrene, beta-naphthoflavone and clofibrate.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Enzyme Induction; Flavonoids; Glucuronates; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
CoA esters of valproic acid and related metabolites are oxidized in peroxisomes through a pathway distinct from peroxisomal fatty and bile acyl-CoA beta-oxidation.
Topics: Acyl Coenzyme A; Animals; Bile Acids and Salts; Clofibrate; Enzyme Induction; Fatty Acid Desaturases; Fatty Acids; Hydrogen Peroxide; In Vitro Techniques; Liver; Male; Microbodies; Rats; Rats, Wistar; Valproic Acid | 1993 |
Pooling samples within microarray studies: a comparative analysis of rat liver transcription response to prototypical toxicants.
Topics: Animals; Clofibrate; Cluster Analysis; Diethylhexyl Phthalate; Fatty Acids; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Liver; Liver Extracts; Male; Mitochondria; Models, Biological; Models, Statistical; Oligonucleotide Array Sequence Analysis; Organ Size; Phenotype; Phylogeny; Principal Component Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Transcription, Genetic; Valproic Acid | 2005 |
Oxidative stress in experimental liver microvesicular steatosis: role of mitochondria and peroxisomes.
Topics: Animals; Anticholesteremic Agents; Clofibrate; Disease Models, Animal; Enzyme Inhibitors; Fatty Liver; Female; Lipid Metabolism; Liver; Mitochondria, Liver; Oxidative Stress; Peroxisomes; Phospholipids; Rats; Rats, Wistar; Valproic Acid | 2006 |