Compounds > valproic acid

valproic acid and chir 99021

valproic acid has been researched along with chir 99021 in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's14 (82.35)24.3611
2020's3 (17.65)2.80

Authors

AuthorsStudies
Clevers, H; Farin, HF; Karp, JM; Langer, R; van Es, JH; Yin, X1
Cheng, L; Guan, W; Hu, W; Pei, G; Qiu, B; Wang, M; Yang, W; Yu, Y; Zhao, J1
Izpisua Belmonte, JC; Li, M; Liu, GH; Wu, MZ1
Baek, S; Choi, H; Heo, YT; Kim, J; Kim, NH; Quan, X; Xu, YN1
Chuva de Sousa Lopes, SM; Kemler, R; Kugler, J; Luch, A; Oelgeschläger, M; Tharmann, J1
Cheng, L; Gao, L; Guan, W; Hu, W; Mao, J; Pei, G; Qiu, B; Yu, Y; Zhao, J1
Chandra, R; Kalsan, M; Kumar, N; Saini, A; Singh, VK1
Akamatsu, W; Kida, YS; Kushige, H; Okano, H; Saito, Y; Shibata, S; Shibuya, Y; Takayama, Y; Wakabayashi, T1
Goh, TW; Hin-Fai Yam, G; Mehta, JS; Setiawan, M; Tan, XW1
Aoi, T; Ishida, R; Kakeji, Y; Koyanagi-Aoi, M; Oshima, N1
Carroll, TD; Chen, Y; Langlands, AJ; Näthke, I1
Cheng, L; Liu, F; Tang, Y; Xiong, S; Yu, P1
Choi, SY; Hahn, S; Jee, J; Jeong, S; Jeong, SY; Kim, HK; Kim, HS; Kim, MS; Park, JS; Shin, H; Yoo, J1
Chen, Y; Cui, G; Li, M; Meng, F; Yu, Z; Zhang, Y1
Hu, M; Li, Y; Ma, Z; Zeng, J1
Aguirre-Vázquez, A; Arriaga-Guerrero, AL; Bermúdez de León, M; Camacho-Moll, ME; Castorena-Torres, F; Dadheech, N; Flores-Ponce, X; Garza-Rodríguez, D; Salazar-Olivo, LA; Velasco, I1
Guo, Y; Liang, Y; Liu, CQ; Ma, CY; Sun, TT; Wang, CJ; Wang, YY; Wu, F; Xu, JJ; Yang, P1

Reviews

2 review(s) available for valproic acid and chir 99021

ArticleYear
Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs).
    Journal of stem cells, 2015, Volume: 10, Issue:1

    Topics: Ascorbic Acid; Butyric Acid; Cell Differentiation; Cellular Reprogramming; Gene Expression; Humans; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Proto-Oncogene Proteins c-myc; Pyridines; Pyrimidines; Regenerative Medicine; SOXB1 Transcription Factors; Transgenes; Valproic Acid

2015
Advances in Small Molecules in Cellular Reprogramming: Effects, Structures, and Mechanisms.
    Current stem cell research & therapy, 2021, Volume: 16, Issue:2

    Topics: Animals; Benzamides; Cellular Reprogramming; Colforsin; Dioxoles; Humans; Mice; Molecular Docking Simulation; Pyridines; Pyrimidines; Regenerative Medicine; Signal Transduction; Valproic Acid

2021

Other Studies

15 other study(ies) available for valproic acid and chir 99021

ArticleYear
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.
    Nature methods, 2014, Volume: 11, Issue:1

    Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Chromosomes; Colon; Flow Cytometry; Green Fluorescent Proteins; Heterozygote; Intestine, Small; Karyotyping; Mice; Microscopy, Confocal; Paneth Cells; Pyridines; Pyrimidines; Receptors, G-Protein-Coupled; Signal Transduction; Stem Cells; Stomach; Valproic Acid

2014
Generation of neural progenitor cells by chemical cocktails and hypoxia.
    Cell research, 2014, Volume: 24, Issue:6

    Topics: Animals; Cell Hypoxia; Cell Lineage; Cell Proliferation; Cells, Cultured; Cluster Analysis; Enzyme Inhibitors; Gene Expression Profiling; Glycogen Synthase Kinase 3; Histone Demethylases; Humans; Mice; Mice, Inbred C57BL; Neural Stem Cells; Pyrazoles; Pyridines; Pyrimidines; Transcriptome; Transforming Growth Factor beta; Valproic Acid

2014
A chemical approach to "rewire" neural progenitor cells.
    Cell research, 2014, Volume: 24, Issue:6

    Topics: Animals; Cell Hypoxia; Enzyme Inhibitors; Humans; Neural Stem Cells; Pyrazoles; Pyridines; Pyrimidines; Valproic Acid

2014
CRISPR/Cas9 nuclease-mediated gene knock-in in bovine-induced pluripotent cells.
    Stem cells and development, 2015, Feb-01, Volume: 24, Issue:3

    Topics: Animals; Animals, Genetically Modified; Benzamides; Blastocyst; Cattle; Cells, Cultured; CRISPR-Cas Systems; Diphenylamine; Fertilization in Vitro; Fibroblasts; Gene Knock-In Techniques; Genetic Engineering; Genetic Enhancement; Genetic Loci; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Homologous Recombination; Induced Pluripotent Stem Cells; Mice; Mice, SCID; Polymorphism, Restriction Fragment Length; Pyridines; Pyrimidines; Recombinant Fusion Proteins; Teratoma; Transcription Factors; Valproic Acid

2015
A Bmp Reporter Transgene Mouse Embryonic Stem Cell Model as a Tool to Identify and Characterize Chemical Teratogens.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 146, Issue:2

    Topics: Animals; Cell Differentiation; Embryonic Stem Cells; Genes, Reporter; Green Fluorescent Proteins; Mice; Mice, Transgenic; Pyridines; Pyrimidines; Teratogens; Transgenes; Valproic Acid

2015
Direct conversion of astrocytes into neuronal cells by drug cocktail.
    Cell research, 2015, Volume: 25, Issue:11

    Topics: Animals; Anticonvulsants; Astrocytes; Gene Expression; Glycogen Synthase Kinase 3; Humans; Mice; Neurons; Pyrazoles; Pyridines; Pyrimidines; Transforming Growth Factor beta; Valproic Acid

2015
Brief exposure to small molecules allows induction of mouse embryonic fibroblasts into neural crest-like precursors.
    FEBS letters, 2017, Volume: 591, Issue:4

    Topics: Adipocytes; Animals; Cell Differentiation; Cells, Cultured; Colforsin; Embryo, Mammalian; Fibroblasts; Gene Expression Profiling; Gene Ontology; Immunohistochemistry; Mice, Inbred C57BL; Microtubule-Associated Proteins; Myocytes, Smooth Muscle; Neural Crest; Neural Stem Cells; Neurons; Osteocytes; Pyridines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Small Molecule Libraries; Time-Lapse Imaging; Tranylcypromine; Valproic Acid

2017
Inhibiting glycogen synthase kinase-3 and transforming growth factor-β signaling to promote epithelial transition of human adipose mesenchymal stem cells.
    Biochemical and biophysical research communications, 2017, 09-02, Volume: 490, Issue:4

    Topics: Adipocytes; Adipose Tissue; Antigens, CD; Cadherins; Cell Movement; Enzyme Inhibitors; Epithelial Cell Adhesion Molecule; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Glycogen Synthase Kinase 3; Humans; Integrin alpha5; Mesenchymal Stem Cells; Occludin; Primary Cell Culture; Pyrazoles; Pyridines; Pyrimidines; Snail Family Transcription Factors; Thiosemicarbazones; Transforming Growth Factor beta1; Tranylcypromine; Tretinoin; Valproic Acid; Vimentin; Xenopus Proteins; Zinc Finger E-box-Binding Homeobox 1; Zonula Occludens-1 Protein

2017
The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition.
    Molecular cancer research : MCR, 2017, Volume: 15, Issue:10

    Topics: Cell Line, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Human Umbilical Vein Endothelial Cells; Humans; Kruppel-Like Factor 4; Neoplastic Stem Cells; NFATC Transcription Factors; Pyridines; Pyrimidines; Spheroids, Cellular; Tacrolimus; Tumor Cells, Cultured; Valproic Acid

2017
Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.
    Cell death & disease, 2018, 02-15, Volume: 9, Issue:3

    Topics: Adenomatous Polyposis Coli Protein; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Hydroxamic Acids; Intestinal Polyposis; Intestine, Small; Loss of Heterozygosity; Mice, Transgenic; Mutation; Pyridines; Pyrimidines; Tissue Culture Techniques; Valproic Acid; Wnt Signaling Pathway

2018
Direct Conversion of Mouse Fibroblasts into Neural Stem Cells by Chemical Cocktail Requires Stepwise Activation of Growth Factors and Nup210.
    Cell reports, 2018, 07-31, Volume: 24, Issue:5

    Topics: Animals; Cell Differentiation; Cells, Cultured; Cellular Reprogramming Techniques; Fibroblast Growth Factor 5; Fibroblasts; Interleukin-6; Mice; Mice, Inbred C57BL; Neural Stem Cells; Nuclear Pore Complex Proteins; Pyrazoles; Pyridines; Pyrimidines; Transcriptome; Valproic Acid

2018
Leucine-rich repeat-containing G-protein coupled receptor 5 enriched organoids under chemically-defined growth conditions.
    Biochemical and biophysical research communications, 2019, 01-08, Volume: 508, Issue:2

    Topics: Adult Stem Cells; Amides; Animals; Cell Self Renewal; Culture Media, Serum-Free; Flavonoids; Gene Expression; Humans; Intestinal Mucosa; Mice; Mice, Transgenic; Organoids; Pyrazoles; Pyridines; Pyrimidines; Receptors, G-Protein-Coupled; RNA, Messenger; Thiosemicarbazones; Valproic Acid

2019
Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells.
    Oncology reports, 2019, Volume: 41, Issue:6

    Topics: Benzamides; Dioxoles; Diphenylamine; Drug Synergism; Epithelial-Mesenchymal Transition; HeLa Cells; Humans; Neoplasms; Neoplastic Stem Cells; Pyridines; Pyrimidines; Valproic Acid

2019
5-Aza-2'-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells.
    Molecules (Basel, Switzerland), 2021, Mar-29, Volume: 26, Issue:7

    Topics: Cell Differentiation; Cell Line; Decitabine; Epigenesis, Genetic; Fibroblasts; Gene Expression; Humans; Kruppel-Like Factor 4; Pyrazoles; Pyridines; Pyrimidines; Thiosemicarbazones; Valproic Acid

2021
[VCR, a Small Molecule Compound, Induces Reprogramming of Rat Fibroblasts into Neural Progenitor Cells under Hypoxic Condition].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2022, Volume: 53, Issue:5

    Topics: Animals; Cell Differentiation; Cells, Cultured; Fibroblasts; Leukemia Inhibitory Factor; Nestin; Neural Stem Cells; Pyrazoles; Pyridines; Pyrimidines; Rats; Trypsin; Valproic Acid

2022