valproic acid has been researched along with carbapenems in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imura-Miyoshi, K; Naganuma, H; Yamamura, N | 1 |
| Fukushima, T; Izumi, M; Takiguchi, Y; Torii, M; Yokota, M | 1 |
| Inagaki, H; Koike, M; Kominami, G; Mizobuchi, M; Nakajima, Y; Nakamura, M; Takagi, H; Yamaguchi, T | 1 |
| Kiribayashi, Y; Maeda, Y; Murakami, T; Nagai, J; Omoda, K; Takano, M; Yumoto, R | 1 |
| Abe, K; Arai, T; Hasebe, N; Horiuchi, M; Kimura, M; Tokumura, M | 1 |
| Hamada, N; Nagai, J; Ogawa, K; Takano, M; Yumoto, R | 1 |
| Mizutani, T; Mori, H; Takahashi, K | 1 |
| Joo, JY; Kim, JH; Kwon, OH; Lee, SG | 1 |
| Mizutani, T; Nakahira, K; Nakamura, Y | 1 |
| Adam, M; Haroutiunian, S; Hoffman, A; Rabinovich, B; Ratz, Y | 1 |
| Gidal, BE; Mancl, EE | 1 |
| Golightly, LK; Jones, MA; Kick, SD; Tobin, JK | 1 |
| Hisaka, A; Honma, M; Ito, K; Masuo, Y; Suzuki, H; Yamamoto, T | 1 |
| Chapman, BA; Hellwig, TR; Onisk, ML | 1 |
| Izumi, T; Kobayashi, N; Nakai, D; Okazaki, O; Suzuki, E; Yamamura, N | 1 |
| Cho, JY; Han, HK; Jang, IJ; Kim, TE; Lim, KS; Park, MK; Shin, KH; Shin, SG; Yi, SJ; Yu, KS | 1 |
| Hammond, DN; Sheth, RD; Taha, FA | 1 |
| Miki, A; Nakamoto, N; Satoh, H; Sawada, Y; Shihyakugari, A | 1 |
| Alcaraz Romero, AJ; Barredo Valderrama, E; de Castro, P; Escudero Vilaplana, V; Fernández Lafever, SN; Fernández-Llamazares, CM; Miranda Herrero, MC; Vázquez López, M | 1 |
| Fusegawa, K; Goda, R; Ikenaga, H; Izumi, T; Kobayashi, N; Kuga, H; Nakai, D; Suzuki, E | 1 |
| Chen, NC; Chen, SD; Chuang, YC; Hsiao, SC; Huang, CR; Lin, CH; Lu, YT; Tsai, WC | 1 |
| Chiba, K; Goda, R; Koyama, K; Kuga, H; Nakai, D; Suzuki, E | 1 |
| Higuchi, N; Ishikawa, T; Kuriyama, M; Mizuta, S; Nakashima, M; Nakashima, MN; Ohyama, K; Onomura, O; Otaki, H | 1 |
| Biggs, AD; Dudley, SW; Erstad, BL; French, RNE; Huckleberry, YC; Khobrani, MA; Kopp, BJ; Shirazi, FM | 1 |
| Ishizuka, T; Kazui, M; Nakai, D; Nishiya, Y; Sakurai, H; Suzuki, E | 1 |
| Chen, IL; Hsiao, SC; Lee, CH; Shih, FY | 1 |
| Akella, J; Sanivarapu, R; Sharma, R | 1 |
| Gao, W; Li, Z; Liu, G; Zhang, Z | 1 |
| Clark, K; Cunningham, D; Lord, K | 1 |
| Chen, R; Dong, L; Hu, N; Jiang, Y; Jiang, Z; Ling, J; Yang, X; Zou, S | 1 |
5 review(s) available for valproic acid and carbapenems
| Article | Year |
|---|---|
Interaction between valproic acid and carbapenem antibiotics.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Carrier Proteins; Drug Interactions; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Erythrocytes; Glucuronidase; Glucuronosyltransferase; Humans; Intestinal Absorption; Intestines; Kidney; Liver; Rats; Uridine Diphosphate Glucuronic Acid; Valproic Acid | 2007 |
The effect of carbapenem antibiotics on plasma concentrations of valproic acid.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Anticonvulsants; Biological Transport; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Humans; Rabbits; Rats; Tissue Distribution; Valproic Acid | 2009 |
Valproic acid-carbapenem interaction: report of six cases and a review of the literature.
Topics: Adult; Aged; Anticonvulsants; Antimanic Agents; Carbapenems; Drug Interactions; Female; Humans; Male; Middle Aged; Recurrence; Retrospective Studies; Seizures; Valproic Acid | 2009 |
Identification of non-P450 enzymes involved in the metabolism of new drugs: Their significance in drug interaction evaluation and prodrug disposition.
Topics: Alcohol Dehydrogenase; Animals; Carbapenems; Carboxylic Ester Hydrolases; Drug Interactions; Humans; Hydrolases; Peptide Hydrolases; Phosphatidate Phosphatase; Prasugrel Hydrochloride; Prodrugs; Pyrrolidinones; Quinolines; Valproic Acid | 2020 |
Treatment of valproic acid overdose with meropenem in an epileptic patient.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Overdose; Epilepsy; Female; Humans; Meropenem; Valproic Acid | 2022 |
25 other study(ies) available for valproic acid and carbapenems
| Article | Year |
|---|---|
Panipenum, a carbapenem antibiotic, increases the level of hepatic UDP-glucuronic acid in rats.
Topics: Animals; Carbapenems; In Vitro Techniques; Liver; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Thienamycins; Uridine Diphosphate Glucuronic Acid; Valproic Acid | 2000 |
Carbapenem antibiotics inhibit valproic acid transport in Caco-2 cell monolayers.
Topics: Anticonvulsants; Biological Transport; Caco-2 Cells; Carbapenems; Humans; Intestinal Mucosa; Valproic Acid | 2002 |
Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats.
Topics: Animals; Anticonvulsants; Bile; Carbapenems; Drug Interactions; Female; Half-Life; Hydrolysis; In Vitro Techniques; Injections, Intravenous; Kidney; Liver; Macaca fascicularis; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Valproic Acid | 2004 |
Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human.
Topics: Adult; Animals; Anticonvulsants; Area Under Curve; Carbapenems; Drug Interactions; Erythrocytes; Female; Humans; Imipenem; Male; Metabolic Clearance Rate; Rats; Rats, Wistar; Thienamycins; Time Factors; Valproic Acid | 2005 |
Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.
Topics: Alanine; Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Convulsants; Dogs; Doripenem; Drug Interactions; Electroencephalography; Injections, Intravenous; Injections, Intraventricular; Male; Meropenem; Mice; Mice, Inbred ICR; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Thienamycins; Valproic Acid | 2006 |
Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Erythrocyte Membrane; Glutathione; Indomethacin; Methotrexate; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Transport Vesicles; Valproic Acid | 2006 |
[Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics].
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Imipenem; Male; Meropenem; Middle Aged; Thienamycins; Valproic Acid | 2007 |
Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibiotics.
Topics: Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Cytosol; Drug Interactions; Enzyme Inhibitors; Glucuronidase; Humans; Hydrolysis; Liver; Microsomes, Liver; Valproic Acid | 2008 |
Valproic acid plasma concentration decreases in a dose-independent manner following administration of meropenem: a retrospective study.
Topics: Anticonvulsants; Carbapenems; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Meropenem; Middle Aged; Retrospective Studies; Thienamycins; Time Factors; Valproic Acid | 2009 |
Characterization of inhibitory effect of carbapenem antibiotics on the deconjugation of valproic acid glucuronide.
Topics: Animals; Carbapenems; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; Glucuronidase; Humans; In Vitro Techniques; Kinetics; Liver; Male; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Valproic Acid | 2010 |
Potential interaction between valproic acid and doripenem.
Topics: Adolescent; Carbapenems; Doripenem; Drug Interactions; Female; Humans; Valproic Acid | 2011 |
Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid.
Topics: Animals; Carbapenems; Cytosol; Dialysis; Humans; Hydrolysis; Isoflurophate; Kinetics; Liver; Meropenem; Peptide Hydrolases; Sus scrofa; Thienamycins; Time Factors; Valproic Acid | 2011 |
Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Carbapenems; Drug Interactions; Drug Monitoring; Female; Half-Life; Humans; Infections; Male; Middle Aged; Retrospective Studies; Seizures; Valproic Acid; Young Adult | 2012 |
Seizures from valproate-carbapenem interaction.
Topics: Adolescent; Anticonvulsants; Carbapenems; Drug Interactions; Female; Humans; Seizures; Valproic Acid | 2013 |
First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.
Topics: Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Child; Drug Interactions; Drug Monitoring; Humans; Male; Medication Errors; Polypharmacy; Seizures; Valproic Acid | 2015 |
Pharmacological interaction between valproic acid and carbapenem: what about levels in pediatrics?
Topics: Adolescent; Anticonvulsants; Carbapenems; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Pediatrics; Retrospective Studies; Seizures; Valproic Acid | 2015 |
In vivo inhibition of acylpeptide hydrolase by carbapenem antibiotics causes the decrease of plasma concentration of valproic acid in dogs.
Topics: Administration, Intravenous; Animals; Carbapenems; Cytosol; Dogs; Drug Interactions; Enzyme Inhibitors; Hydrolysis; Kidney; Liver; Male; Meropenem; Peptide Hydrolases; Protease Inhibitors; Thienamycins; Valproic Acid | 2016 |
Drug interaction between valproic acid and carbapenems in patients with epileptic seizures.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Bacterial Infections; Carbapenems; Contraindications; Drug Antagonism; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Risk Factors; Valproic Acid | 2017 |
Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics.
Topics: Animals; Carbapenems; Drug Interactions; Humans; Liver; Meropenem; Mice; Peptide Hydrolases; Thienamycins; Transplantation Chimera; Valproic Acid | 2017 |
Computational study of the competitive binding of valproic acid glucuronide and carbapenem antibiotics to acylpeptide hydrolase.
Topics: Binding, Competitive; Carbapenems; Humans; Models, Molecular; Molecular Structure; Peptide Hydrolases; Valproic Acid | 2017 |
Intentional use of carbapenem antibiotics for valproic acid toxicity: A case report.
Topics: Anticonvulsants; Carbapenems; Drug Interactions; Humans; Male; Meropenem; Middle Aged; Valproic Acid | 2018 |
Interactions between carbapenems and valproic acid among the patients in the intensive care units.
Topics: Adult; Anticonvulsants; Carbapenems; Drug Interactions; Humans; Intensive Care Units; Valproic Acid | 2021 |
Thinking out of the box: management of valproic acid toxicity with carbapenems.
Topics: Adult; Anticonvulsants; Carbapenems; Carnitine; Epilepsy; Female; Humans; Meropenem; Valproic Acid | 2021 |
Interaction between valproic acid and carbapenems: decreased plasma concentration of valproic acid and liver injury.
Topics: Carbapenems; Humans; Liver; Pharmaceutical Preparations; Retrospective Studies; Valproic Acid | 2021 |
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Valproic Acid | 2023 |