valproic acid has been researched along with aspartic acid in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (48.72) | 18.7374 |
| 1990's | 4 (10.26) | 18.2507 |
| 2000's | 10 (25.64) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| Authors | Studies |
|---|---|
| Grove, J; Schechter, PJ; Tranier, Y | 1 |
| Sarhan, S; Seiler, N | 1 |
| Hansson, E; Nilsson, M; Rönnbäck, L | 1 |
| Hiramatsu, M; Kanakura, K; Kinno, I; Mori, A; Sato, K | 1 |
| Chung, EY; Rosenbaum, D; Van Woert, MH | 1 |
| Hauhart, RE; Thurston, JH | 1 |
| Farrant, M; Webster, RA | 1 |
| Baverel, G; Martin, G; Michoudet, C | 1 |
| Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A | 1 |
| Bhargava, KP; Gupta, GP; Gupta, MB | 1 |
| Kapetanovic, IM; Kupferberg, HJ; Torchin, CD; Yonekawa, WD | 1 |
| Chapman, AG | 1 |
| Ferrara, LP; Slevin, JT | 1 |
| Dostert, P; Rumigny, JF; Strolin Benedetti, M | 1 |
| Lascelles, PT; Patsalos, PN | 1 |
| Davidoff, RA; Grayson, V; Hackman, JC | 1 |
| Chapman, A; Keane, PE; Meldrum, BS; Simiand, J; Vernieres, JC | 1 |
| Bruni, J; Hammond, EJ; Wilder, BJ | 1 |
| Chapman, AG; Meldrum, BS; Mendes, E | 1 |
| Chapman, AG; Meldrum, BS | 1 |
| Chapman, AG; Croucher, MJ; Meldrum, BS | 1 |
| Biggs, CS; Fowler, LJ; Pearce, BR; Whitton, PS | 1 |
| Cantello, R; Gianelli, M; Monaco, F; Mutani, R; Naldi, P; Schiavella, MP; Torta, R; Verzé, L | 1 |
| Masereeuw, R; Russel, FG; Tanriseven, O; Terlouw, SA | 1 |
| Fonnum, F; Hassel, B; Johannessen, CU; Petersen, D | 1 |
| Klisch, J; Schumacher, M; Spreer, J; Thiel, T; Ziyeh, S | 1 |
| Grimee, R; Klitgaard, H; Margineanu, DG; Matagne, A; Vanneste-Goemaere, J | 1 |
| Asghar, SJ; Hanstock, CC; O'Donnell, T; Silverstone, PH; Ulrich, M; Wu, RH | 1 |
| Hanstock, CC; Nakashima, TT; O'Donnell, T; Rotzinger, S; Silverstone, PH; Ulrich, M | 1 |
| Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ | 1 |
| Barreiro, CJ; Baumgartner, WA; Berrong, J; Blue, ME; Gott, VL; Johnston, MV; Kratz, LE; Lange, MS; Nwakanma, LU; Patel, ND; Troncoso, JC; Williams, JA | 1 |
| Aguirre, G; López-Bayghen, E; Ortega, A; Rosas, S | 1 |
| Buechert, M; Garcia, M; Huppertz, HJ; Mader, I; Schumacher, M; Ziyeh, S | 1 |
| Xie, W; Yu, Y; Zhao, Y | 1 |
| Gundersen, V; Morland, C; Nordengen, K | 1 |
| Allegri, M; Bianchi, MG; Bussolati, O; Chiu, M; Franchi-Gazzola, R; Reia, L; Sala, R; Uggeri, J | 1 |
| Correa-Basurto, J; Fonseca-Sabater, Y; Fragoso-Vazquez, MJ; Luna-Palencia, GR; Martinez-Ramos, F; Mendez-Luna, D; Mendieta-Wejebe, JE; Meraz-Rios, MA; Padilla-Martínez, II; Sixto-Lopez, Y; Trujillo-Ferrara, J; Vasquez-Moctezuma, I | 1 |
| Chakrabarti, P; Chatterjee, BK; Chatterjee, T; Das, G; Dhar, J; Ghosh, S | 1 |
| Chen, J; Jiang, G; Li, R; Long, X; Lv, J; Wang, J; Xie, T; Ye, L | 1 |
5 review(s) available for valproic acid and aspartic acid
| Article | Year |
|---|---|
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; Flurazepam; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Light; Morphine; Muscimol; Myoclonus; Serotonin; Urea; Valproic Acid | 1986 |
[Mechanisms of action and biochemical toxicology of valproic acid].
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Ammonia; Animals; Anticonvulsants; Aspartic Acid; Brain; Chemical and Drug Induced Liver Injury; gamma-Aminobutyric Acid; Gluconeogenesis; Glutamate Decarboxylase; Humans; Hydroxybutyrate Dehydrogenase; Neurons; Receptors, Neurotransmitter; Valproic Acid | 1984 |
Mechanism of anticonvulsant action of valproate.
Topics: Animals; Aspartic Acid; Cats; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Half-Life; Humans; Intestinal Absorption; Kinetics; Mental Disorders; Mice; Movement Disorders; Neurotransmitter Agents; Protein Binding; Rabbits; Rats; Valproic Acid | 1982 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; Animals; Aspartic Acid; Brain; Cyclic GMP; Dyskinesia, Drug-Induced; Electric Stimulation; Electrophysiology; Epilepsies, Partial; gamma-Aminobutyric Acid; Glycine; Humans; Nervous System Diseases; Neurons; Seizures; Serotonin; Succinate-Semialdehyde Dehydrogenase; Succinates; Valproic Acid | 1981 |
Effects of anticonvulsant drugs on brain amino acid metabolism.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Benzodiazepines; Biomechanical Phenomena; Brain; Enzyme Activation; gamma-Aminobutyric Acid; Glutamates; Glycine; Humans; Neural Inhibition; Phenobarbital; Synapses; Valproic Acid | 1983 |
2 trial(s) available for valproic acid and aspartic acid
| Article | Year |
|---|---|
Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients.
Topics: Adult; Antidepressive Agents; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Cerebral Cortex; Choline; Creatine; Drug Administration Schedule; Female; Humans; Inositol; Lithium; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Valproic Acid | 2003 |
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Protons; Reference Values; Valproic Acid | 2003 |
32 other study(ies) available for valproic acid and aspartic acid
| Article | Year |
|---|---|
Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity.
Topics: Animals; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Kinetics; Male; Mice; Noise; Seizures; Valproic Acid | 1978 |
Metabolic inhibitors and subcellular distribution of GABA.
Topics: 3-Mercaptopropionic Acid; Aminocaproates; Animals; Anticonvulsants; Aromatic-L-Amino-Acid Decarboxylases; Aspartic Acid; Centrifugation, Density Gradient; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Male; Mice; Pyridoxal Phosphate; Synaptosomes; Valproic Acid | 1979 |
Interactions between valproate, glutamate, aspartate, and GABA with respect to uptake in astroglial primary cultures.
Topics: Animals; Aspartic Acid; Astrocytes; Biological Transport; Cells, Cultured; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kinetics; Rats; Rats, Inbred Strains; Valproic Acid | 1992 |
Increased aspartate release from brain slices of epileptic experimental animals and effect of valproate on it.
Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; In Vitro Techniques; Mice; Mice, Neurologic Mutants; Valproic Acid | 1992 |
Biochemistry and therapeutics of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aspartic Acid; Benzodiazepines; Carbidopa; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Humans; Hydroxyindoleacetic Acid; Hypoxia; Methysergide; Models, Biological; Myoclonus; Prednisone; Serotonin; Tryptophan; Valproic Acid | 1986 |
Valproate doubles the anoxic survival time of normal developing mice: possible relevance to valproate-induced decreases in cerebral levels of glutamate and aspartate, and increases in taurine.
Topics: Animals; Animals, Suckling; Aspartic Acid; Body Weight; Brain; Glucose; Glutamates; Hypoxia; Mice; Taurine; Valproic Acid | 1989 |
Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproate.
Topics: Action Potentials; Amino Acids; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Substantia Nigra; Valproic Acid | 1989 |
Stimulation of glutamine metabolism by the antiepileptic drug, sodium valproate, in isolated dog kidney tubules.
Topics: Alanine; Ammonia; Animals; Aspartic Acid; Dogs; Female; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kidney Tubules; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid; Valproic Acid | 1989 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Female; Mice; N-Methylaspartate; Phenobarbital; Seizures; Synaptic Transmission; Valproic Acid | 1987 |
Central GABA-ergic mechanism in stress-induced gastric ulceration.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cold Temperature; Epinephrine; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Humans; Hydrogen-Ion Concentration; Injections, Intraventricular; Male; Neurotransmitter Agents; Picrotoxin; Pylorus; Rats; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Valproic Acid | 1985 |
Effects of pharmacological manipulations on basal and newly synthesized levels of GABA, glutamate, aspartate and glutamine in mouse brain cortex.
Topics: 2-Amino-5-phosphonovalerate; 3-Mercaptopropionic Acid; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Male; Mice; N-Methylaspartate; Valproic Acid | 1988 |
Chronic valproic acid therapy and synaptic markers of amino acid neurotransmission.
Topics: Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Male; Rats; Valproic Acid | 1985 |
Changes in regional brain levels of amino acid putative neurotransmitters after prolonged treatment with the anticonvulsant drugs diphenylhydantoin, phenobarbitone, sodium valproate, ethosuximide, and sulthiame in the rat.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Ethosuximide; gamma-Aminobutyric Acid; Glutamates; Male; Neurotransmitter Agents; Organ Specificity; Phenobarbital; Phenytoin; Rats; Taurine; Thiazines; Valproic Acid | 1981 |
The presynaptic effects of valproic acid in the isolated frog spinal cord.
Topics: Afferent Pathways; Animals; Aspartic Acid; Electric Conductivity; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Potassium; Rana pipiens; Spinal Cord; Synapses; Valproic Acid | 1981 |
Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Mice; Mice, Inbred DBA; Seizures; Structure-Activity Relationship; Valproic Acid | 1983 |
Anticonvulsant activity of intracerebroventricularly administered valproate and valproate analogues. A dose-dependent correlation with changes in brain aspartate and GABA levels in DBA/2 mice.
Topics: Animals; Anticonvulsants; Aspartic Acid; Brain Chemistry; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Mice; Mice, Inbred DBA; Valproic Acid | 1984 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Isoniazid; Kinetics; Male; Potassium; Rats; Rats, Wistar; Seizures; Taurine; Valproic Acid | 1994 |
Plasma amino acid alterations in idiopathic generalized epilepsy: an investigation in probands and their first-degree relatives.
Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy; Family; Female; Glutamates; Glycine; Humans; Male; Taurine; Valproic Acid | 1994 |
Metabolite anion carriers mediate the uptake of the anionic drug fluorescein in renal cortical mitochondria.
Topics: Animals; Aspartic Acid; Biological Transport; Carrier Proteins; Fluorescein; Glutamic Acid; Ketoglutaric Acids; Kidney Cortex; Mitochondria; Rats; Succinates; Tricarboxylic Acids; Valproic Acid | 2000 |
The acute effect of valproate on cerebral energy metabolism in mice.
Topics: Acetates; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Brain; Citric Acid Cycle; Energy Metabolism; Female; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Phosphocreatine; Valproic Acid | 2001 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Occipital Lobe; Valproic Acid | 2002 |
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Aspartic Acid; Clonazepam; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Injections, Intraperitoneal; Levetiracetam; Male; Microinjections; Phenobarbital; Pilocarpine; Piracetam; Rats; Rats, Sprague-Dawley; Valproic Acid | 2003 |
Effects of chronic lithium and sodium valproate on concentrations of brain amino acids.
Topics: Alanine; Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Lithium; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Taurine; Valproic Acid | 2003 |
Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery.
Topics: Animals; Apoptosis; Aspartic Acid; Behavior, Animal; Biomarkers; Brain; Brain Chemistry; Brain Damage, Chronic; Cardiopulmonary Bypass; Circulatory Arrest, Deep Hypothermia Induced; Consciousness Disorders; Cranial Nerve Diseases; Dogs; Drug Evaluation, Preclinical; Histone Deacetylase Inhibitors; Hypoxia-Ischemia, Brain; Male; Movement Disorders; Necrosis; Neuroprotective Agents; Sensation Disorders; Single-Blind Method; Valproic Acid | 2006 |
Valproate-dependent transcriptional regulation of GLAST/EAAT1 expression: involvement of Ying-Yang 1.
Topics: Acetylation; Animals; Anticonvulsants; Aspartic Acid; Blotting, Western; Cell Membrane; Cells, Cultured; Chick Embryo; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Excitatory Amino Acid Transporter 1; Gene Expression Regulation; Histones; Neuroglia; Reverse Transcriptase Polymerase Chain Reaction; Sodium; Stimulation, Chemical; Valproic Acid; YY1 Transcription Factor | 2008 |
Valproate-induced metabolic changes in patients with epilepsy: assessment with H-MRS.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Choline; Creatine; Energy Metabolism; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Female; Glutamic Acid; Glutamine; Humans; Hyperammonemia; Image Processing, Computer-Assisted; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Occipital Lobe; Parietal Lobe; Reference Values; Valproic Acid; Young Adult | 2009 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease Models, Animal; Drugs, Chinese Herbal; Epilepsy; Glutamic Acid; Hippocampus; Humans; Kindling, Neurologic; Male; Pentylenetetrazole; Random Allocation; Rats; Valproic Acid | 2010 |
Valproate causes reduction of the excitatory amino acid aspartate in nerve terminals.
Topics: Animals; Anticonvulsants; Aspartic Acid; CA3 Region, Hippocampal; Male; Neurotransmitter Agents; Presynaptic Terminals; Rats; Rats, Wistar; Valproic Acid | 2012 |
Valproic acid induces the glutamate transporter excitatory amino acid transporter-3 in human oligodendroglioma cells.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Anticonvulsants; Aspartic Acid; Cell Line, Tumor; Enzyme Inhibitors; Excitatory Amino Acid Transporter 3; Gene Expression Regulation, Neoplastic; Glial Fibrillary Acidic Protein; Humans; Oligodendroglioma; Phorbol 12,13-Dibutyrate; Protein Transport; Receptor, Platelet-Derived Growth Factor alpha; RNA, Messenger; Signal Transduction; Time Factors; Tritium; Tubulin; Valproic Acid | 2012 |
Three amino acid derivatives of valproic acid: design, synthesis, theoretical and experimental evaluation as anticancer agents.
Topics: Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Glutamic Acid; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Molecular Docking Simulation; Molecular Dynamics Simulation; Proline; Repressor Proteins; Structure-Activity Relationship; Valproic Acid | 2014 |
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anticonvulsants; Aspartic Acid; Benzothiazoles; Brain; Dioxolanes; Epilepsy; Humans; Isoaspartic Acid; Neurons; PC12 Cells; Peptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Rats; Structure-Activity Relationship; Valproic Acid | 2020 |
Magnetic resonance imaging features of hippocampus and mechanism of neurocognitive dysfunction for antiepileptic drugs in treatment of depression rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Creatine; Depression; Hippocampus; Magnetic Resonance Imaging; Rats; Rats, Sprague-Dawley; Valproic Acid | 2022 |