valproic acid has been researched along with ascorbic acid in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Crespi, F; Keane, PE; Morre, M | 1 |
| Lerer, B | 1 |
| Abbott, FS; Huang, HS; Jurima-Romet, M; Tang, W; Whitehouse, LW | 1 |
| Nazarali, AJ; Wang, X; Zhang, B | 1 |
| Hsieh, CL; Peng, CC; Peng, RY; Tsai, WJ; Wang, HE | 1 |
| Blom, H; Frisch, C; Linnebank, M; Semmler, A; Smith, D | 1 |
| Chen, J; Dai, Y; Ding, Y; Li, H; Li, S; Tan, M; Wang, C; Wu, J | 1 |
| Huang, H; Kaimin, H; Lifei, Z; Lizhen, L; Ru, L; Shan, F; Yulin, X | 1 |
| Aikawa, N; Kunisato, A; Kusaka, H; Nagao, K; Ohgami, K; Takaba, K | 1 |
| Huang, Y; Li, T; Li, Z; Ouyang, H; Pang, D; Wang, A; Wang, B; Yuan, L | 1 |
| Chandra, R; Kalsan, M; Kumar, N; Saini, A; Singh, VK | 1 |
| Cossenza, M; de Souza, JM; Domith, I; Dos Santos Assunção, F; Ferreira, MJ; Garcia, CG; Geraldo, LHM; Kahn, SA; Lima, FRS; Netto, ADP; Portugal, CC; Romano, I; Romão, LF; Silva, DCLE | 1 |
| Fu, H; Jiang, G; Ju, X; Sun, X | 1 |
| Ding, C; Huang, B; Li, D; Li, H; Liu, Q; Pan, T; Shen, H; Yuan, S | 1 |
| Marchant, JS; Moradi, H; Subramanian, VS; Teafatiller, T | 1 |
| Kitazawa, M; Marquez, FE; Subramanian, S; Subramanian, VS; Teafatiller, T | 1 |
| Akbar, N; Anum, H; Haneef, K; Razzaq, SS; Salim, A; Usman, S | 1 |
3 review(s) available for valproic acid and ascorbic acid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Alternative therapies for bipolar disorder.
Topics: Ascorbic Acid; Bipolar Disorder; Bupropion; Carbamazepine; Choline; Clonazepam; Clonidine; Clorgyline; Demeclocycline; Fenfluramine; Humans; Methylene Blue; Phosphatidylcholines; Physostigmine; Propiophenones; Propranolol; Spironolactone; Thyroxine; Tryptophan; Valproic Acid | 1985 |
Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs).
Topics: Ascorbic Acid; Butyric Acid; Cell Differentiation; Cellular Reprogramming; Gene Expression; Humans; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Nuclear Transfer Techniques; Octamer Transcription Factor-3; Proto-Oncogene Proteins c-myc; Pyridines; Pyrimidines; Regenerative Medicine; SOXB1 Transcription Factors; Transgenes; Valproic Acid | 2015 |
19 other study(ies) available for valproic acid and ascorbic acid
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Anaesthesia abolishes the effect of valproate on extracellular 5-HIAA, DOPAC and ascorbate as measured in rat striatum by differential pulse voltammetry.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia; Animals; Ascorbic Acid; Corpus Striatum; Dopamine; Hydroxyindoleacetic Acid; Male; Phenylacetates; Rats; Rats, Inbred Strains; Serotonin; Valproic Acid | 1986 |
Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.
Topics: Analysis of Variance; Animals; Anticonvulsants; Ascorbic Acid; Cells, Cultured; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Enzyme Inhibitors; Glutathione; Homeostasis; L-Lactate Dehydrogenase; Liver; Male; Mass Spectrometry; Methionine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; Valproic Acid; Vitamin E | 1996 |
Ascorbic acid reverses valproic acid-induced inhibition of hoxa2 and maintains glutathione homeostasis in mouse embryos in culture.
Topics: Animals; Antioxidants; Ascorbic Acid; Embryo Culture Techniques; Embryo, Mammalian; Gene Expression Regulation, Developmental; Glutathione; Homeodomain Proteins; Homeostasis; Mice; Models, Biological; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid | 2010 |
Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.
Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Chick Embryo; Chromatography, High Pressure Liquid; Folic Acid; Foot Deformities; Glutathione; Hindlimb; Histone Deacetylases; Homocysteine; Hydrogen Peroxide; Joints; Muscle, Skeletal; Neovascularization, Physiologic; Superoxide Dismutase; Teratogens; Tissue Embedding; Valproic Acid; Vitamins | 2012 |
The ratio of S-adenosylmethione and S-adenosyl-homocysteine is increased in the brains of newborn rats in a model of valproic acid teratogenicity.
Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Folic Acid; Teratogens; Valproic Acid; Vitamins | 2012 |
Characterizing the effects of VPA, VC and RCCS on rabbit keratocytes onto decellularized bovine cornea.
Topics: Animals; Apoptosis; Ascorbic Acid; Cattle; Cell Culture Techniques; Cell Proliferation; Chondroitin Sulfate Proteoglycans; Cornea; Corneal Keratocytes; Flow Cytometry; Keratan Sulfate; Lumican; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Proteoglycans; Rabbits; Tissue Engineering; Valproic Acid; Vimentin | 2012 |
Efficient generation of induced pluripotent stem cells from human bone marrow mesenchymal stem cells.
Topics: Animals; Ascorbic Acid; Biomarkers; Bone Marrow Cells; Cell Culture Techniques; Cell Cycle; Cellular Reprogramming; Down-Regulation; Humans; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; Multipotent Stem Cells; Octamer Transcription Factor-3; RNA, Small Interfering; Tumor Suppressor Protein p53; Up-Regulation; Valproic Acid | 2012 |
Detection of thalidomide embryotoxicity by in vitro embryotoxicity testing based on human iPS cells.
Topics: Ascorbic Acid; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Fibroblasts; Humans; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Skin; Teratogens; Thalidomide; Toxicity Tests; Valproic Acid | 2014 |
Valproic Acid Improves Porcine Parthenogenetic Embryo Development Through Transient Remodeling of Histone Modifiers.
Topics: Animals; Ascorbic Acid; Blastocyst; Embryo, Mammalian; Embryonic Development; Female; Fertilization in Vitro; Histones; Microscopy, Fluorescence; Swine; Valproic Acid | 2015 |
Combination Therapy with Sulfasalazine and Valproic Acid Promotes Human Glioblastoma Cell Death Through Imbalance of the Intracellular Oxidative Response.
Topics: Amino Acid Transport System y+; Animals; Ascorbic Acid; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Drug Therapy, Combination; Glioblastoma; Glutathione; Humans; Intracellular Space; Mesoderm; Neuroglia; Oxidation-Reduction; Rats; Sulfasalazine; Time Factors; Valproic Acid | 2018 |
MELAS and macroangiopathy: A case report and literature review.
Topics: Acidosis, Lactic; Adult; Arginine; Ascorbic Acid; Carotid Stenosis; Humans; Male; MELAS Syndrome; Mitochondrial Encephalomyopathies; Point Mutation; Ubiquinone; Valproic Acid | 2018 |
Vitamin C- and Valproic Acid-Induced Fetal RPE Stem-like Cells Recover Retinal Degeneration via Regulating SOX2.
Topics: Animals; Ascorbic Acid; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fetal Stem Cells; Gene Expression Regulation; Humans; Mice; Retinal Degeneration; Retinal Pigment Epithelium; SOXB1 Transcription Factors; Treatment Outcome; Up-Regulation; Valproic Acid | 2020 |
Histone deacetylase inhibitors regulate vitamin C transporter functional expression in intestinal epithelial cells.
Topics: Acetylation; Animals; Ascorbic Acid; Butyric Acid; Caco-2 Cells; Epigenesis, Genetic; Epithelial Cells; Histone Deacetylase Inhibitors; Humans; Intestinal Mucosa; Jejunum; Mice; Mice, Inbred BALB C; Promoter Regions, Genetic; RNA, Small Interfering; Sodium-Coupled Vitamin C Transporters; Valproic Acid | 2021 |
Valproic acid upregulates sodium-dependent vitamin C transporter-2 functional expression in neuronal cells.
Topics: Animals; Ascorbic Acid; Histone Deacetylase Inhibitors; Humans; Mice; Neuroblastoma; Protein Isoforms; RNA, Heterogeneous Nuclear; RNA, Messenger; Sodium-Coupled Vitamin C Transporters; Transcription Factors; Valproic Acid; Vitamins | 2022 |
Ascorbic acid and salvianolic acid B enhance the valproic acid and 5-azacytidinemediated cardiac differentiation of mesenchymal stem cells.
Topics: Ascorbic Acid; Azacitidine; Cardiovascular Diseases; Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Myocytes, Cardiac; Valproic Acid | 2023 |