valproic acid and arginine

valproic acid has been researched along with arginine in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's8 (32.00)18.2507
2000's4 (16.00)29.6817
2010's10 (40.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Mori, A; Shiraga, H; Watanabe, Y1
Christmann, D; Collard, M; Colombo, JP; Hirsch, E; Marescaux, C; Mutschler, V1
Johnson, BD; Morgan, HB; Swaiman, KF1
Collins, AF; Dover, GJ; Luban, NL1
Gerecke, U; Koch, R; Löscher, W; Mevissen, M; Richter, A; Rundfeldt, C1
Böhles, HJ; Demirkol, M; Herwig, J; Sewell, AC1
Czuczwar, SJ; Kleinrok, Z; Klonowski, P; Tutka, P1
Balakrishnan, S; Pandhi, P1
Brill, J; Fernald, RD; Huguenard, JR; Lee, M; Zhao, S1
Bek, S; Cakir, E; Gökçil, Z; Odabaşi, Z; Oz, O1
Dorszewska, J; Kaczmarek, I; Sniezawska, A; Steinborn, B; Winczewska-Wiktor, A1
Aydogdu, SD; Colak, O; Dinleyici, EC; Ozdemir, O; Yakut, A; Yarar, C1
Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A1
Walker, V1
Ito, M; Nambu, K; Noguchi, S; Sakon, A; Terada, K; Uekusa, H; Yonemochi, E1
Eyer, F; Felgenhauer, N; Fernando, M; Rabe, C; Schrettl, V1
Fu, H; Jiang, G; Ju, X; Sun, X1
Hayashi, D; Miyazaki, Y; Okubo, T; Suzuki, T; Takizawa, T; Tanaka, K; Usami, M1
Abd El Hady, NMS; Abdallah, HM; Abdelmageed, SM; Aboelghar, HM; Garib, MI; Mahmoud, AA1
Bicaku, E; Daud, AI; Marchion, DC; Munster, PN; Sullivan, DM; Turner, JG1

Reviews

4 review(s) available for valproic acid and arginine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Late diagnosis of congenital argininemia during administration of sodium valproate].
    Revue neurologique, 1990, Volume: 146, Issue:12

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Epilepsy; Female; Humans; Psychomotor Disorders; Valproic Acid

1990
[Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy].
    Przeglad lekarski, 2009, Volume: 66, Issue:8

    Topics: Anticonvulsants; Arginine; Carbamazepine; Epilepsy; Homocysteine; Humans; Nitric Oxide; Nitric Oxide Synthase; Valproic Acid

2009
Ammonia metabolism and hyperammonemic disorders.
    Advances in clinical chemistry, 2014, Volume: 67

    Topics: Ammonia; Animals; Arginine; Biological Transport; Brain; Cell Membrane; Humans; Hyperammonemia; Hyperinsulinism; Liver; Liver Diseases; Pyruvate Carboxylase Deficiency Disease; Syndrome; Urea; Urologic Diseases; Valproic Acid

2014

Other Studies

21 other study(ies) available for valproic acid and arginine

ArticleYear
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism

1999
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Guanidino compound levels in the serum of healthy adults and epileptic patients.
    Epilepsy research, 1991, Volume: 8, Issue:2

    Topics: Adult; Arginine; Creatinine; Epilepsy; Female; Glycine; Guanidines; Homoarginine; Humans; Male; Phenanthrenes; Sex Factors; Valproic Acid

1991
Diagnosis of argininosuccinic aciduria after valproic acid-induced hyperammonemia.
    Neurology, 1987, Volume: 37, Issue:5

    Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinic Acid; Female; Humans; Male; Metabolic Diseases; Valproic Acid

1987
Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy.
    Blood, 1994, Sep-01, Volume: 84, Issue:5

    Topics: Adult; Amides; Arginine; Butyrates; Epilepsy; Fetal Hemoglobin; Humans; Phenylacetates; Phenylbutyrates; Reference Values; Valproic Acid

1994
Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.
    European journal of pharmacology, 1995, Feb-14, Volume: 274, Issue:1-3

    Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Epilepsy; Female; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures; Valproic Acid

1995
Neurological deterioration in patients with urea cycle disorders under valproate therapy--a cause for concern.
    European journal of pediatrics, 1995, Volume: 154, Issue:7

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Child; Epilepsy; Female; Humans; Hyperargininemia; Neurologic Examination; Risk Factors; Valproic Acid

1995
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
    European journal of pharmacology, 1999, Feb-05, Volume: 366, Issue:2-3

    Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Ethosuximide; Male; Mice; Nitroarginine; Pentylenetetrazole; Phenobarbital; Psychomotor Performance; Seizures; Valproic Acid

1999
Cognitive dysfunction induced by phenytoin and valproate in rats: effect of nitric oxide.
    Indian journal of physiology and pharmacology, 1999, Volume: 43, Issue:3

    Topics: Animals; Anticonvulsants; Arginine; Cognition Disorders; Enzyme Inhibitors; Female; Male; Memory; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Phenytoin; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Valproic Acid

1999
Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jun-21, Volume: 26, Issue:25

    Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Arginine; Drug Administration Schedule; Gene Expression Regulation; Immunohistochemistry; In Vitro Techniques; Midline Thalamic Nuclei; Neuropeptide Y; Phosphopyruvate Hydratase; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Valproic Acid

2006
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
    Epilepsy research, 2009, Volume: 87, Issue:1

    Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Male; Statistics, Nonparametric; Valproic Acid; Vitamin B 12

2009
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
    European journal of pediatrics, 2011, Volume: 170, Issue:7

    Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Cholesterol; Cross-Sectional Studies; Drug Administration Schedule; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lipids; Male; Triglycerides; Valproic Acid; Vitamin B 12; Vitamin B Complex

2011
Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs.
    Seizure, 2013, Volume: 22, Issue:2

    Topics: Adolescent; Anticonvulsants; Arginine; Atherosclerosis; Biomarkers; Carbamazepine; Child; Epilepsy; Female; Homocysteine; Humans; Male; Nitric Oxide; Oxcarbazepine; Prospective Studies; Risk Factors; Valproic Acid

2013
Mechanisms for Improved Hygroscopicity of L-Arginine Valproate Revealed by X-Ray Single Crystal Structure Analysis.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:3

    Topics: Arginine; Crystallization; Crystallography, X-Ray; Valproic Acid; Water; Wettability; X-Ray Diffraction

2017
L-Arginine in the treatment of valproate overdose - five clinical cases.
    Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:4

    Topics: Acyl Coenzyme A; Adult; Amino-Acid N-Acetyltransferase; Ammonia; Arginine; Carnitine; Coma; Drug Overdose; Female; Humans; Hyperammonemia; Male; Renal Dialysis; Valproic Acid

2017
MELAS and macroangiopathy: A case report and literature review.
    Medicine, 2018, Volume: 97, Issue:52

    Topics: Acidosis, Lactic; Adult; Arginine; Ascorbic Acid; Carotid Stenosis; Humans; Male; MELAS Syndrome; Mitochondrial Encephalomyopathies; Point Mutation; Ubiquinone; Valproic Acid

2018
Valproic acid up-regulates the whole NO-citrulline cycle for potent iNOS-NO signaling to promote neuronal differentiation of adipose tissue-derived stem cells.
    Nitric oxide : biology and chemistry, 2021, 01-01, Volume: 106

    Topics: Adipose Tissue; Animals; Arginine; Argininosuccinate Synthase; Cell Differentiation; Citrulline; Enzyme Inhibitors; Male; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase Type II; Rats, Wistar; Signal Transduction; Stem Cells; Up-Regulation; Valproic Acid

2021
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
    Pediatric research, 2022, Volume: 92, Issue:6

    Topics: Anticonvulsants; Arginine; Carotid Intima-Media Thickness; Child; Epilepsy; Homocysteine; Humans; Levetiracetam; Valproic Acid

2022
Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Dec-01, Volume: 11, Issue:23

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Butyrates; Chromatin; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Antisense; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression Profiling; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mitoxantrone; Neoplasms; Oligonucleotide Array Sequence Analysis; RNA, Small Interfering; Teniposide; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Valproic Acid

2005