valproic acid has been researched along with arachidonic acid in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gecse, A; Kis, B; Mezei, Z; Szupera, Z; Telegdy, G; Vécsei, L | 1 |
| Bell, JM; Chang, MC; Contreras, MA; Rapoport, SI; Rintala, JJ; Rosenberger, TA | 1 |
| Bosetti, F; Rapoport, SI | 1 |
| Bosetti, F; Rapoport, SI; Rosenberger, TA; Weerasinghe, GR | 1 |
| Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI | 1 |
| Bazinet, RP; Rapoport, SI; Rosenberger, TA; Weis, MT | 1 |
| Bazinet, RP; Lee, HJ; Rao, JS; Rapoport, SI | 1 |
| Basselin, M; Bell, JM; Chang, L; Chen, M; Rapoport, SI | 1 |
| Bazinet, RP | 1 |
| Basselin, M; Coleman, RA; Li, LO; Modi, HR; Rapoport, SI; Shimshoni, JA | 1 |
| Basselin, M; Chang, L; Chen, M; Cheon, Y; Ramadan, E; Rapoport, SI; Taha, AY | 1 |
| Basselin, M; Bialer, M; Coleman, RA; Li, LO; Modi, HR; Rapoport, SI; Taha, AY | 1 |
| Basselin, M; Modi, HR; Rapoport, SI | 1 |
3 review(s) available for valproic acid and arachidonic acid
| Article | Year |
|---|---|
Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?
Topics: Animals; Anticonvulsants; Antimanic Agents; Arachidonic Acid; Bipolar Disorder; Brain; Brain Chemistry; Cyclooxygenase 2; Docosahexaenoic Acids; Humans; Isoenzymes; Lithium; Membrane Proteins; Models, Animal; Palmitic Acid; Phospholipids; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Rats; Valproic Acid | 2002 |
Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?
Topics: Antimanic Agents; Arachidonic Acid; Bipolar Disorder; Brain; Carbamazepine; Humans; Lithium; Valproic Acid | 2008 |
Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder?
Topics: Animals; Anticonvulsants; Antidepressive Agents; Arachidonic Acid; Bipolar Disorder; Brain; Carbamazepine; Fructose; Humans; Lamotrigine; Lithium Compounds; Molecular Structure; Signal Transduction; Topiramate; Triazines; Valproic Acid | 2009 |
10 other study(ies) available for valproic acid and arachidonic acid
| Article | Year |
|---|---|
The effects of valproate on the arachidonic acid metabolism of rat brain microvessels and of platelets.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Anticonvulsants; Arachidonic Acid; Blood Platelets; Brain; Capillaries; Male; Rats; Rats, Wistar; Valproic Acid | 2000 |
Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers.
Topics: Acyl Coenzyme A; Animals; Antimanic Agents; Arachidonic Acid; Brain; Brain Chemistry; Fatty Acids; Fatty Acids, Nonesterified; Gene Expression; Kinetics; Lithium; Male; Phospholipases A; Phospholipids; Rats; Rats, Inbred F344; Tritium; Valproic Acid | 2001 |
Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain.
Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Brain Chemistry; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Down-Regulation; Drug Administration Schedule; Eicosanoids; Enzyme Activation; Isoenzymes; Leukotriene B4; Male; Membrane Proteins; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; RNA, Messenger; Thromboxane B2; Valproic Acid | 2003 |
Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat.
Topics: Acyl Coenzyme A; Animals; Anticonvulsants; Arachidonic Acid; Brain; Docosahexaenoic Acids; Fatty Acids; Injections, Intraperitoneal; Linoleic Acid; Long-Term Care; Phospholipids; Rats; Rats, Inbred F344; Valproic Acid | 2005 |
Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder.
Topics: Acyl Coenzyme A; Animals; Antimanic Agents; Arachidonic Acid; Bipolar Disorder; Brain; Coenzyme A Ligases; Docosahexaenoic Acids; In Vitro Techniques; Microsomes; Palmitic Acid; Rats; Valproic Acid | 2006 |
Chronic administration of valproic acid reduces brain NMDA signaling via arachidonic acid in unanesthetized rats.
Topics: Animals; Arachidonic Acid; Autoradiography; Behavior, Animal; Brain; Dinoprostone; Male; N-Methylaspartate; Rats; Rats, Inbred F344; Signal Transduction; Thromboxane B2; Valproic Acid | 2008 |
Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder.
Topics: Acylation; Animals; Anticonvulsants; Arachidonic Acid; Arachidonic Acids; Bipolar Disorder; Brain; Coenzyme A Ligases; Docosahexaenoic Acids; Enzyme Activation; Escherichia coli; Humans; Isoenzymes; Nerve Tissue Proteins; Rats; Recombinant Proteins; Valproic Acid | 2011 |
Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats.
Topics: Analysis of Variance; Animals; Antimanic Agents; Arachidonic Acid; Autoradiography; Brain; Carbon Radioisotopes; Dinoprostone; Dopamine Agonists; Dopamine Antagonists; Male; Rats; Rats, Inbred F344; Receptors, Dopamine D2; Signal Transduction; Thromboxane B2; Valproic Acid | 2011 |
Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder.
Topics: Acylation; Animals; Antimanic Agents; Arachidonic Acid; Bipolar Disorder; Coenzyme A Ligases; Molecular Structure; Rats; Valproic Acid | 2013 |
Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4.
Topics: Amides; Arachidonic Acid; Coenzyme A Ligases; Dose-Response Relationship, Drug; Enzyme Activation; In Vitro Techniques; Iodine Isotopes; Models, Statistical; Valproic Acid | 2014 |