valproic acid and ammonium hydroxide

valproic acid has been researched along with ammonium hydroxide in 191 studies

Research

Studies (191)

Timeframe	Studies, this research(%)	All Research%
pre-1990	74 (38.74)	18.7374
1990's	49 (25.65)	18.2507
2000's	32 (16.75)	29.6817
2010's	24 (12.57)	24.3611
2020's	12 (6.28)	2.80

Authors

Authors	Studies
Sannita, WG	1
Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB	1
Levy, RH; Stephens, JR	1
Bacon, BR; Kane, RE; Kotagel, S; Vogler, CA	1
Callahan, K; Evans, B; Honeycutt, D; Rutledge, L	1
Baverel, G; Durozard, D; Martin, G	1
Cataltepe, S; Coşkun, T; Ozalp, I; Tokatli, A	1
Iwamoto, H; Kobayashi, T; Matsui, K; Miyake, S; Ohtsuki, N; Yamada, M	1
Alonso, C; Camiña, MF; Castro-Gago, M; Paz, JM; Rodriguez-Segade, S; Rozas, I	2
Carter, PE; Cole, GF; Stevenson, KL; Thom, H	1
Albani, F; Baruzzi, A; Campostrini, R; Galli, G; Paganini, M; Riva, R; Zaccara, G	1
Camiña, MF; Castro-Gago, M; Novo-Rodriguez, I; Rodrigo-Saez, E; Rodriguez-Segade, S	1
Baverel, G; Besson, J; Durozard, D; Martin, G	1
Biesenbach, R; Haupt, M; Rommel, A; Rommel, KF; Schmidt, W; Wiedemann, G	1
Christmann, D; Collard, M; Colombo, JP; Hirsch, E; Marescaux, C; Mutschler, V	1
Alonso, E; García-España, A; Girbés, J; Rubio, V	1
Culebras, M; Doval, M; Gougoux, H; López-Novoa, JM; Rengel, M; Vinay, P	1
Cremel, G; Marescaux, C; Rumbach, L; Waksman, A; Warter, JM	1
Culebras, M; Doval, M; López-Novoa, JM; Rengel, M	1
Baverel, G; Martin, G; Michoudet, C	1
Hjelm, M; Kay, JD; Oberholzer, V; Seakins, J; Thomas, S	1
Kodama, S; Komatsu, M; Konishi, H; Matsuo, T; Momota, K; Tanaka, K; Wada, H; Yokoyama, S	1
Alhayek, G; Alquier, P; Bourrier, P; Kamoun, P; Lorre, G; Rabier, D; Varache, N	1
de Silva, LV; Hjelm, M; Oberholzer, VG; Rolles, CJ; Seakins, JW	1
Chabrier, G; Imler, M; Marescaux, C; Warter, JM	1
Matsuda, I; Ninomiya, N; Ohtani, Y	1
Laub, MC	1
Ettlin, T; Scollo-Lavizzari, G	1
Hoffmann, S; Purdie, G; Ratnaike, RN; Rischbieth, RH; Schapel, GJ	1
Abbott, FS; Applegarth, DA; Farrell, K; Jan, JE; Orr, JM; Wong, PK	1
Böhles, H	1
Johnson, BD; Morgan, HB; Swaiman, KF	1
Arnetoli, G; Campostrini, R; Messori, A; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R	1
Arnetoli, G; Bendoni, L; Campostrini, R; Moroni, F; Paganini, M; Zaccara, G; Zappoli, R	1
Hosokawa, K; Kugoh, T	1
Hosokawa, K; Kugoh, T; Yamamoto, M	1
Uetrecht, JP	1
Harris, RA; Swartzentruber, MS	1
Beckner, RR; Marini, AM; Zaret, BS	1
Gal, P; Gilman, JT; Oles, KS; Weaver, R	1
Baverel, G; Ferrier, B; Martin, M	1
Kobayashi, Y; Nishida, N; Sugimoto, T; Takeuchi, T	1
Culebras, M; Doval, M; Gougoux, A; López-Novoa, JM; Rengel, M; Vinay, P	1
Gougoux, A; Lopez-Novoa, JM; Rengel-Aranda, M; Vinay, P	1
Hayasaka, K; Hori, K; Iinuma, K; Narisawa, K; Tada, K	1
Gastaut, JL; Mege, JL	1
Marini, AM; Zaret, BS	1
Brandt, C; Chabrier, G; Imler, M; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Keane, PE; Morre, M	1
Arnetoli, G; Bartelli, M; Campostrini, R; Messori, A; Moroni, F; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R	1
Chabrier, G; Hirsch, E; Imler, M; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Campostrini, R; Dorigotti, A; Paganini, M; Rossi, L; Zaccara, G; Zappoli, R	1
Haidukewych, D; John, G; Rodin, EA; Zielinski, JJ	1
Akiyama, T; Ishikawa, T; Kanayama, M; Morishita, H; Sugiyama, N; Wada, Y	1
Dostert, P; Rumigny, JF; Strolin Benedetti, M	1
Allen, RJ; Coulter, DL	2
Casaer, P; Corbeel, L; Jaeken, J	1
Anthony, PP; Hargreaves, T; Leonard, JV; Miller, P; Oberholzer, VG; Patrick, AD; Searle, JF; Tripp, JH	1
Imler, M; Koehl, C; Kurtz, D; Laroye, M; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Chabrier, G; Imler, M; Krieger, J; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Hansen, HE; Hartmann-Andersen, F; Husted, SE; Mortensen, PB; Pedersen, B	1
Brandt, C; Chabrier, G; Imler, M; Krieger, J; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Matsumura, T; Nishida, N; Ono, A; Sakane, Y; Sugimoto, T; Yasuhara, A	1
Brandt, C; Chabrier, G; Imler, M; Kurtz, D; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Cruse, RP; Erenberg, G; Rothner, AD; Wyllie, E; Wyllie, R	1
Arnetoli, G; Boncinelli, L; Campostrini, R; Paganini, M; Zaccara, G; Zappoli, R	1
Applegarth, DA; Farrell, K; Kirby, LT; Verity, CM	1
Chabrier, G; Collard, M; Imler, M; Koehl, C; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Buttery, JE; Hoffmann, S; Ratnaike, RN	1
McReynolds, JW; Tiefenbach, S; Williams, CA	1
Igarashi, Y; Narisawa, K; Oka, S; Tada, K	1
Arnetoli, G; Campostrini, R; Moroni, F; Paganini, M; Zaccara, G; Zappoli, R	1
Powell-Jackson, PR; Tredger, JM; Williams, R	1
Chabrier, G; Imler, M; Marescaux, C; Micheletti, B; Rumbach, L; Warter, JM	1
Chabrier, G; Imler, M; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Chabrier, G; Hirsch, E; Imler, M; Marescaux, C; Micheletti, G; Reitzer, B; Rumbach, L; Warter, JM	1
Arnetoli, G; Baruzzi, A; Campostrini, R; Moroni, F; Paganini, M; Targioni, G; Valenza, T; Zaccara, G; Zappoli, R	1
Angelastro, R; Arnetoli, G; Bartelli, M; Campostrini, R; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R	1
Cathelineau, L; Coude, FX; Grimber, G; Kamoun, PP; Parvy, P; Rabier, D	1
Borkowski, WJ; Rawat, S; Swick, HM	1
Galmiche, J; Imler, M; Koehl, C; Marescaux, C; Micheletti, G; Rumbach, L; Warter, JM	1
Coulter, D	1
Beckner, RR; Marini, AM; Passarelli, C; Wagle, W; Zaret, BS	1
Batshaw, ML; Brusilow, SW	1
Marquardt, K; Murphy, JV	1
Endo, F; Matsuda, I; Ohtani, Y	1
Imler, M; Marescaux, C; Warter, JM	1
Cathelineau, L; Coudé, FX; Grimber, G; Kamoun, P; Parvy, P; Rabier, D	1
Böhles, HJ; Demirkol, M; Herwig, J; Sewell, AC	1
Settle, EC	1
Baganz, MD; Dross, PE	1
Leão, M	1
Treem, WR	1
Baverel, G; Elhamri, M; Ferrier, B; Martin, M	2
Bohu, PA; Bourreille, J; Héron, F; Kerleau, JM; Manchon, ND	1
Kramer, DA; Kulick, SK	1
Balestra, V; DiBon, G; Hassan, KM; Rosadini, G; Sannita, WG	1
Bernard, G; Mattei, A; Paliard, P; Plauchu, G	1
Clavería, LE; Coria, F; Duarte, J; Fernandez, E; Macias, S	1
Horiuchi, M; Imamura, Y; Maruyama, I; Nakamura, N; Saheki, T	1
Murakami, K; Muro, H; Nishida, N; Sugimoto, T; Woo, M	1
Böhles, H; Sewell, AC; Wenzel, D	1
Raby, WN	1
Antonopolous, J; Gidal, BE; Inglese, CM; Meyer, JF; Pitterle, ME; Rust, RS	1
Jiménez, C; Lluch-Fernández, MD; Marchante-Serrano, C; Navarro-Quesada, FJ; Vaquero-Abellán, M	1
Altunbaşak, S; Baytok, V; Burgut, R; Hergüner, O; Kayrin, L; Tasouji, M	1
Hirose, S; Mitsudome, A; Muta, Y; Ogawa, A; Tomoda, Y; Yasumoto, S	1
Kohlschütter, A; Oechsner, M; Steen, C; Stürenburg, HJ	1
Balducci, A; Capocchi, G; Cecconi, M; Pelli, MA; Picchiarelli, A; Silvestrelli, G; Zampolini, M	1
Amano, T; Ichikawa, H; Kawabata, K; Kushiro, M; Makino, H; Nagake, Y; Wada, J	1
Donley, B; Eze, E; Workman, M	1
Bohan, TP; Coulter, DL; De Vivo, DC; Dreifuss, FE; Greenwood, RS; Nordli, DR; Shields, WD; Stafstrom, CE; Tein, I	1
Chen, YF; Deng, JF; Lee, WL; Lin, HD; Wang, PH; Yang, CC	1
Bräunig, P; Göbel, R; Görtzen, A	1
Behar, KL; Hyder, F; Mattson, RH; Petroff, OA; Rothman, DL	1
Chiarelli, F; Greco, R; Morgese, G; Verrotti, A	1
Gilman, SM; Panikkar, GP	1
Nikiforov, AA; Ostretsova, IB; Zagryadskaya, EI	1
Bakker, JA; Forget, PP; Spaapen, LJ; van Oosterhout, M; Vles, JS; Wermuth, B	1
Hamer, HM; Knake, S; Rosenow, F; Schomburg, U	1
Hirata, K; Katayama, S; Miyamoto, M; Miyamoto, T	1
El-Chaar, GM; Raskind, JY	1
Akata, T; Kifune, A; Kikuchi, S; Kubota, F; Shibata, N	1
Amamou, M; Ben Salah, N; Brahmi, N; Hédhili, A; Thabet, H	1
Solomon, GE	1
Arrigoni-Martelli, E; Caso, V	1
Amusini, P; Bruel, H; Chabrolle, JP; Iskandar, K; Levesque, L; Poinsot, J	1
Chen, WT; Liao, KK; Yen, DJ; Yu, HY	1
Cawthon, DF; Caylor, LM; Kraemer, DL; Morgan, JD; Ojemann, LM; Vossler, DG; Wilensky, AJ	1
Gehlen, F; Georgiadis, D; Mayatepek, E; Schwab, S; Schwarz, S; Zoubaa, S	1
Bagnasco, T; LoVecchio, F; Thole, D	1
Murphy, JV	1
Burneo, JG; Faught, E; Knowlton, RC; Kuzniecky, RI; Lawn, N; Limdi, N; Mendez, M; Prasad, A; Welty, TE	1
Caraccio, TR; Mofenson, HC	1
McKay, CA; Perez, A	1
Allain, H; Beauplet, A; Bentué-Ferrer, D; Biraben, A; Latour, P; Polard, E; Tribut, O	1
Babin, S; Mallet, L; Morais, JA	1
Bourgeois, JA; McCall, M	1
Baverel, G; Gauthier, C; Martin, G; Michoudet, C; Vittorelli, A	1
Albertson, T; Camilleri, C; Offerman, S	1
Panda, S; Radhakrishnan, K	1
Gazioğlu, S; Velioğlu, SK	1
Chicharro, AV; de Marinis, AJ; Kanner, AM	1
Meulenbelt, J; Mier, JC; Sikma, MA	1
Carr, RB; Nicolai, J	1
Ando, Y; Goto, S; Hagiwara, T; Ishitsu, T; Nagata, S; Nakagawa, K; Seo, T; Ueda, K; Yamauchi, T	1
Driessen, JT; Groenhuijzen, A; Maas, HA; Meinardi, MC; van den Berg, GB; Wolfhagen, FH	1
Flowers, CM; Knudsen, JF; Sokol, GH	1
Chen, CY; Chou, HF; Jong, YJ; Yang, RC	1
Beasley, MT; Cofield, S; DeWolfe, JL; Faught, E; Knowlton, RC; Limdi, NA	1
Abi-Saab, W; Chang, K; Kowatch, RA; Redden, L; Saltarelli, M; Segal, S; Vigna, NV; Wagner, KD; Wilens, TE; Wozniak, P	1
Abdella, MM; Hamed, SA	1
Castiñeiras-Ramos, DE; Castro-Gago, M; Díaz-Mayo, I; Eirís-Puñal, J; Gómez-Lado, C	1
Bøen, A; Bøhmer, T; Høymork, SC	1
Bhudhisawadi, K; Chulavatnatol, S; Kaojareon, S; Vaewpanich, J; Visudtibhan, A	1
Bourque, DL; LaBuzetta, JN; Yao, JZ; Zivin, J	1
Gulati, S; Gupta, YK; Kabra, M; Kalra, V; Sharma, S; Vasisht, S	1
Briand, G; Dobbelaere, D; Joncquel-Chevalier Curt, M; Mention-Mulliez, K; Vamecq, J	1
Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Silva, MF; van Cruchten, A; Wanders, RJ	1
Hong, L; Nance, M; Schutz, J	1
Fujisaki, K; Itoh, H; Sato, Y; Suzuki, Y; Takeyama, M	1
Chan, E; McQueen, F	1
Sampath, S; Sivathanu, S; Sunderkumar, S; Veerasamy, M	1
Alvariza, S; Fagiolino, P; Guevara, N; Ibarra, M; Magallanes, L; Maldonado, C; Olano, I; Olmos, I; Vázquez, M	1
Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R	1
Chang, CC; Chang, WN; Chen, NC; Chuang, YC; Huang, CR; Lin, CH; Lu, CH; Lu, YT; Tseng, YL	1
Walker, V	1
Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y	1
Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M	1
Eyer, F; Felgenhauer, N; Fernando, M; Rabe, C; Schrettl, V	1
Elger, CE; Kipervasser, S; Korczyn, AD; Nass, RD; Neufeld, MY; Quesada, CM	1
Li, X; Zhang, T; Zhao, L; Zhu, X	1
Camilleri, L	1
El-Kersh, K; Gearhart, AM; Guardiola, JJ	1
Araki, M; Mukai, T; Naka, H; Shishido, T; Tokinobu, H; Yamada, H	1
Clavero Olmos, M; Moreno Rosauro, JM; Pliego Cosano, R	1
Ishioka, M; Kubo, K; Miyazaki, K; Nakagami, T; Shimoda, K; Sugawara, N; Tarakita, N; Yasui-Furukori, N; Yokoyama, S	1
Clothier, J; Ganapathy, V; Grooms, A; Kopel, J	1
Britton, JW; Hocker, SE; Smith, KM; Toledano, M	1
Chen, J; Chen, X; Chen, Y; Miao, J; Wang, R; Zeng, J; Zhuang, X	1
Balestrini, S; Murphy, E; Sisodiya, SM; Vakrinou, A; Vivekananda, U	1
Dutkiewicz, J; Pilut, D; Szczygieł-Pilut, EE; Zajączkowska-Dutkiewicz, A	1
Ezhilarasan, D; Mani, U	1
Aghamollaii, V; Ghayyem, H; Hassani, M; Hosseini, H; Mayeli, M; Shafie, M; Shakiba, A	1
Fagiolino, P; Ibarra, M; Maldonado, C; Schiavo, A; Trocóniz, IF; Vázquez, M	1
Ryan, A; Shakerdi, L	1
Fang, Y; Fang, Z; Hui, L; Yu-E, Y; Zheng-Li, D; Zhi-Qin, L	1
Kim, DW; Kwack, DW	1

Reviews

18 review(s) available for valproic acid and ammonium hydroxide

Article	Year
Valproate hepatotoxicity syndrome: hypotheses of pathogenesis. Pharmaceutisch weekblad. Scientific edition, 1992, Jun-19, Volume: 14, Issue:3A Topics: Ammonia; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Diseases; Syndrome; Valproic Acid	1992
[Late diagnosis of congenital argininemia during administration of sodium valproate]. Revue neurologique, 1990, Volume: 146, Issue:12 Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Epilepsy; Female; Humans; Psychomotor Disorders; Valproic Acid	1990
[Mechanisms of action and biochemical toxicology of valproic acid]. L'Encephale, 1984, Volume: 10, Issue:4 Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Ammonia; Animals; Anticonvulsants; Aspartic Acid; Brain; Chemical and Drug Induced Liver Injury; gamma-Aminobutyric Acid; Gluconeogenesis; Glutamate Decarboxylase; Humans; Hydroxybutyrate Dehydrogenase; Neurons; Receptors, Neurotransmitter; Valproic Acid	1984
Hepatotoxicity to sodium valproate: a review. Gut, 1984, Volume: 25, Issue:6 Topics: Adolescent; Adult; Ammonia; Animals; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Liver; Liver Function Tests; Male; Mice; Middle Aged; Rats; Reye Syndrome; Valproic Acid	1984
Inherited and acquired syndromes of hyperammonemia and encephalopathy in children. Seminars in liver disease, 1994, Volume: 14, Issue:3 Topics: Ammonia; Child; Hepatic Encephalopathy; Humans; Liver Diseases; Metabolism, Inborn Errors; Reye Syndrome; Urea; Valproic Acid	1994
Valproate-induced coma: case report and literature review. The Annals of pharmacotherapy, 1993, Volume: 27, Issue:5 Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid	1993
The role of carnitine supplementation during valproic acid therapy. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:5 Topics: Adolescent; Adult; Aged; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Humans; Infant; Middle Aged; Myoclonus; Spasms, Infantile; Valproic Acid	2000
Carnitine protects mitochondria and removes toxic acyls from xenobiotics. Drugs under experimental and clinical research, 2001, Volume: 27, Issue:1 Topics: Acyl Coenzyme A; Ammonia; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Antineoplastic Agents; Bacterial Toxins; Carnitine; Humans; Mitochondria; Pentanoic Acids; Peroxisome Proliferators; Valproic Acid; Xenobiotics	2001
The measurement of ammonia blood levels in patients taking valproic acid: looking for problems where they do not exist? Epilepsy & behavior : E&B, 2007, Volume: 11, Issue:3 Topics: Ammonia; Anticonvulsants; Epilepsy; Female; Humans; Male; MEDLINE; Retrospective Studies; Valproic Acid	2007
Adult nonhepatic hyperammonemia: a case report and differential diagnosis. The American journal of medicine, 2010, Volume: 123, Issue:10 Topics: Ammonia; Diagnosis, Differential; Humans; Hyperammonemia; Liver Diseases; Male; Metabolism, Inborn Errors; Middle Aged; Urea; Valproic Acid	2010
Valproate-induced hyperammonaemia superimposed upon severe neuropsychiatric lupus: a case report and review of the literature. Clinical rheumatology, 2013, Volume: 32, Issue:3 Topics: Ammonia; Antimanic Agents; Fatal Outcome; Female; Humans; Hyperammonemia; Lupus Vasculitis, Central Nervous System; Treatment Outcome; Valproic Acid; Young Adult	2013
Ammonia metabolism and hyperammonemic disorders. Advances in clinical chemistry, 2014, Volume: 67 Topics: Ammonia; Animals; Arginine; Biological Transport; Brain; Cell Membrane; Humans; Hyperammonemia; Hyperinsulinism; Liver; Liver Diseases; Pyruvate Carboxylase Deficiency Disease; Syndrome; Urea; Urologic Diseases; Valproic Acid	2014
Lesson of the month 1: Sodium valproate-induced encephalopathy. Clinical medicine (London, England), 2018, Volume: 18, Issue:5 Topics: Aged; Ammonia; Anticonvulsants; Brain Diseases; Carnitine; Consciousness Disorders; Epilepsy; Humans; Hyperammonemia; Male; Polypharmacy; Valproic Acid	2018
[Valproic acid-induced hyperammonemic encephalopathy in a patient receiving valproic acid monotherapy]. Rinsho shinkeigaku = Clinical neurology, 2019, May-28, Volume: 59, Issue:5 Topics: Aged; Ammonia; Anticonvulsants; Biomarkers; Cardiomyopathies; Carnitine; Consciousness Disorders; Epilepsy, Generalized; Female; Humans; Hyperammonemia; Muscular Diseases; Neurotoxicity Syndromes; Status Epilepticus; Valproic Acid	2019
Risk factors and outcome of hyperammonaemia in people with epilepsy. Journal of neurology, 2022, Volume: 269, Issue:12 Topics: Adult; Ammonia; Epilepsy; Humans; Hyperammonemia; Observational Studies as Topic; Oxcarbazepine; Risk Factors; Valproic Acid	2022
Valproic acid induced liver injury: An insight into molecular toxicological mechanism. Environmental toxicology and pharmacology, 2022, Volume: 95 Topics: Adenosine Triphosphate; Ammonia; Anticonvulsants; Carnitine O-Palmitoyltransferase; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Coenzyme A; DNA, Mitochondrial; Glutathione; Humans; Liver; Peroxisome Proliferator-Activated Receptors; Protons; Transaminases; Triglycerides; Valproic Acid	2022
Drug-induced hyperammonaemia. Journal of clinical pathology, 2023, Volume: 76, Issue:8 Topics: Ammonia; Brain; Child; Humans; Hyperammonemia; Valproic Acid	2023
Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy. Clinical neurology and neurosurgery, 2023, Volume: 233 Topics: Adult; Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risk Factors; Topiramate; Valproic Acid	2023

Trials

9 trial(s) available for valproic acid and ammonium hydroxide

Article	Year
Increase of valproate-induced hyperammonemia in normal subjects by carbohydrate intake. Neurology, 1984, Volume: 34, Issue:11 Topics: Ammonia; Carbohydrate Metabolism; Humans; Male; Valproic Acid	1984
Carnitine deficiency and hyperammonemia associated with valproic acid therapy. The Journal of pediatrics, 1982, Volume: 101, Issue:5 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Clinical Trials as Topic; Humans; Valproic Acid	1982
The effect of carnitine supplementation in valproate-induced hyperammonaemia. Acta paediatrica (Oslo, Norway : 1992), 1996, Volume: 85, Issue:4 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Liver Diseases; Male; Time Factors; Valproic Acid	1996
Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures. Seizure, 1999, Volume: 8, Issue:2 Topics: Adult; Ammonia; Anticonvulsants; Astrocytes; Epilepsy, Complex Partial; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Occipital Lobe; Refractory Period, Electrophysiological; Valproic Acid	1999
Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients. The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:2 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Body Weight; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Infant; Japan; Liver Function Tests; Male; Middle Aged; Regression Analysis; Risk Factors; Sex Factors; Transaminases; Valproic Acid	2008
Hyperammonemia following intravenous valproate loading. Epilepsy research, 2009, Volume: 85, Issue:1 Topics: Adult; Aged; Ammonia; Analysis of Variance; Anticonvulsants; Bilirubin; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Female; Humans; Hyperammonemia; Injections, Intravenous; Male; Middle Aged; Prospective Studies; Time Factors; Valproic Acid; Young Adult	2009
A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 2009, Volume: 48, Issue:5 Topics: Adolescent; Ammonia; Analysis of Variance; Antimanic Agents; Bipolar Disorder; Child; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Psychiatric Status Rating Scales; Reference Values; Surveys and Questionnaires; Treatment Outcome; Valproic Acid	2009
The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status. Epilepsy research, 2009, Volume: 86, Issue:1 Topics: Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Epilepsy; Female; Humans; Hyperammonemia; Male; Prospective Studies; Valproic Acid; Vitamin B Complex	2009
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. BioMed research international, 2016, Volume: 2016 Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Valproic Acid	2016

Other Studies

164 other study(ies) available for valproic acid and ammonium hydroxide

Article	Year
Valproate acute administration, EEG epileptic abnormalities, and ammonemia. Neurology, 1992, Volume: 42, Issue:10 Topics: Adolescent; Adult; Ammonia; Electroencephalography; Epilepsy; Female; Humans; Male; Valproic Acid	1992
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. Acta neurologica Scandinavica, 1992, Volume: 86, Issue:3 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia); Coma; Corpus Callosum; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy, Generalized; Female; Glutamine; Humans; Phenytoin; Tomography, X-Ray Computed; Valproic Acid	1992
Valproate use associated with persistent hyperammonemia and mitochondrial injury in a child with Down's syndrome. Journal of pediatric gastroenterology and nutrition, 1992, Volume: 14, Issue:2 Topics: Ammonia; Bone Marrow; Child, Preschool; Down Syndrome; Follow-Up Studies; Humans; Liver; Male; Mitochondria; Prothrombin Time; Seizures; Serum Albumin; Valproic Acid	1992
Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy. Neurology, 1992, Volume: 42, Issue:3 Pt 1 Topics: Adult; Ammonia; Female; Heterozygote; Humans; Metabolic Diseases; Ornithine Carbamoyltransferase Deficiency Disease; Seizures; Valproic Acid	1992
Valproate-induced alterations of coenzyme A and coenzyme A ester concentrations in human kidney tubules metabolizing glutamine. Contributions to nephrology, 1991, Volume: 92 Topics: Acetyl Coenzyme A; Adult; Ammonia; Coenzyme A; Glutamine; Humans; In Vitro Techniques; Kidney Tubules; Valproic Acid	1991
Valproate-induced lethal hyperammonaemic coma in a carrier of ornithine carbamoyltransferase deficiency. Journal of inherited metabolic disease, 1991, Volume: 14, Issue:5 Topics: Ammonia; Child, Preschool; Coma; Epilepsy; Female; Heterozygote; Humans; Ornithine Carbamoyltransferase Deficiency Disease; Valproic Acid	1991
[The problems of valproate therapy in severely handicapped children--valproate induced hyperammonemia and hypocarnitinemia]. No to hattatsu = Brain and development, 1991, Volume: 23, Issue:1 Topics: Adolescent; Adult; Ammonia; Carnitine; Child; Child, Preschool; Disabled Persons; Enteral Nutrition; Epilepsy; Female; Humans; Male; Valproic Acid	1991
Alteration of renal carnitine metabolism by anticonvulsant treatment. Neurology, 1991, Volume: 41, Issue:9 Topics: Ammonia; Animals; Anticonvulsants; Carbamazepine; Carnitine; Male; Mice; Phenobarbital; Phenytoin; Valproic Acid	1991
Ammonia and carnitine concentrations in children treated with sodium valproate compared with other anticonvulsant drugs. Developmental medicine and child neurology, 1991, Volume: 33, Issue:9 Topics: Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; Humans; Male; Valproic Acid	1991
Effects of acute valproic acid administration on carnitine plasma concentrations in epileptic patients. Epilepsy research, 1991, Volume: 8, Issue:2 Topics: Adult; Ammonia; Carnitine; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid	1991
Hyperaminoacidemia in epileptic children treated with valproic acid. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1990, Volume: 6, Issue:8 Topics: Adolescent; Amino Acids; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Valproic Acid	1990
Effects of acute valproate administration on carnitine metabolism in mouse serum and tissues. Biochemical pharmacology, 1990, Jan-01, Volume: 39, Issue:1 Topics: Ammonia; Animals; Caprylates; Carnitine; Kidney; Kinetics; Liver; Male; Mice; Muscles; Myocardium; Valproic Acid	1990
Effect of the antiepileptic drug sodium valproate on glutamine and glutamate metabolism in isolated human kidney tubules. Biochimica et biophysica acta, 1990, Mar-26, Volume: 1033, Issue:3 Topics: Adult; Ammonia; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Humans; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Stimulation, Chemical; Valproic Acid	1990
[Incidence of pathologic ammonia concentrations in the plasma in children with seizure disorders treated with Convulsofin/Convulex and other anticonvulsants in comparison with children with brain damage and healthy children]. Kinderarztliche Praxis, 1990, Volume: 58, Issue:1 Topics: Adolescent; Ammonia; Anticonvulsants; Brain Damage, Chronic; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Valproic Acid	1990
Changes in urea cycle-related metabolites in the mouse after combined administration of valproic acid and an amino acid load. Archives of biochemistry and biophysics, 1989, Aug-01, Volume: 272, Issue:2 Topics: Amino Acids; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Citrulline; Glutamates; Glutamine; Liver; Mice; Ornithine; Urea; Valproic Acid	1989
Effect of valproate infusion in vivo on renal metabolism in fasted rats. Biochemical pharmacology, 1989, Oct-15, Volume: 38, Issue:20 Topics: Ammonia; Animals; Fasting; Kidney; Male; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Valproic Acid	1989
Valproate-induced hyperammonemia of renal origin. Effects of valproate on glutamine transport in rat kidney mitochondria. Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22 Topics: Ammonia; Animals; Binding, Competitive; Biological Transport; Glutamine; Kidney; Kinetics; Male; Mitochondria; Rats; Rats, Inbred Strains; Valproic Acid	1989
The early effects of valproic acid in low doses in liver metabolism. Revista espanola de fisiologia, 1989, Volume: 45, Issue:4 Topics: Amino Acids; Ammonia; Animals; Citric Acid Cycle; Glucose; Liver; Male; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Valproic Acid	1989
Stimulation of glutamine metabolism by the antiepileptic drug, sodium valproate, in isolated dog kidney tubules. Biochemical pharmacology, 1989, Nov-15, Volume: 38, Issue:22 Topics: Alanine; Ammonia; Animals; Aspartic Acid; Dogs; Female; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kidney Tubules; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid; Valproic Acid	1989
Valproate-induced inhibition of urea synthesis and hyperammonaemia in healthy subjects. Lancet (London, England), 1986, Oct-11, Volume: 2, Issue:8511 Topics: Adult; Ammonia; Female; Humans; Male; Middle Aged; Urea; Valproic Acid	1986
Valproate-associated hyperammonemia and DL-carnitine supplement. The Kobe journal of medical sciences, 1987, Volume: 33, Issue:3 Topics: Adolescent; Adult; Ammonia; Carbamazepine; Carnitine; Child; Child, Preschool; Disabled Persons; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Valproic Acid	1987
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase]. Presse medicale (Paris, France : 1983), 1988, Nov-05, Volume: 17, Issue:39 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Edema; Carbamoyl-Phosphate Synthase (Ammonia); Humans; Male; Suicide, Attempted; Urea; Valproic Acid	1988
Evidence of inherited urea cycle defect in a case of fatal valproate toxicity. British medical journal (Clinical research ed.), 1986, Jan-04, Volume: 292, Issue:6512 Topics: Adult; Ammonia; Child; Child, Preschool; Female; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Orotic Acid; Urea; Valproic Acid	1986
Effects of 2,4-dinitrophenol on renal ammoniagenesis in the rat. European journal of pharmacology, 1986, Apr-16, Volume: 123, Issue:2 Topics: 2,4-Dinitrophenol; Ammonia; Animals; Biological Transport, Active; Dinitrophenols; Glutamine; Kidney; Male; Rats; Rats, Inbred Strains; Valproic Acid	1986
Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy. The Journal of pediatrics, 1986, Volume: 109, Issue:1 Topics: Ammonia; Carnitine; Epilepsy; Humans; Infant; Intellectual Disability; Kidney; Metabolic Clearance Rate; Reye Syndrome; Valproic Acid	1986
[Hyperammonemia in valproate therapy in children and adolescents]. Der Nervenarzt, 1986, Volume: 57, Issue:5 Topics: Adolescent; Ammonia; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Valproic Acid	1986
[Hyperammonemia during sodium valproate therapy: clinically relevant or accidental finding?]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Jul-15, Volume: 75, Issue:29 Topics: Adult; Aged; Ammonia; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid	1986
Hyperammonaemia and hepatotoxicity during chronic valproate therapy: enhancement by combination with other antiepileptic drugs. British journal of clinical pharmacology, 1986, Volume: 22, Issue:1 Topics: Adolescent; Adult; Aged; Ammonia; Anticonvulsants; Bilirubin; Drug Synergism; Drug Therapy, Combination; Erythrocytes; Female; Humans; Liver; Liver Function Tests; Male; Middle Aged; Valproic Acid	1986
Free and total serum valproate concentrations: their relationship to seizure control, liver enzymes and plasma ammonia in children. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1986, Volume: 13, Issue:3 Topics: Adolescent; Adult; Ammonia; Aspartate Aminotransferases; Child; Child, Preschool; Humans; Infant; Liver; Osmolar Concentration; Seizures; Valproic Acid	1986
[When is parenteral carnitine administration indicated?]. Beitrage zu Infusionstherapie und klinische Ernahrung, 1986, Volume: 13 Topics: Acidosis; Adult; Ammonia; Carnitine; Fat Emulsions, Intravenous; Humans; Infant, Newborn; Infant, Premature, Diseases; Infections; Kidney Failure, Chronic; Liver Cirrhosis; Parenteral Nutrition, Total; Valproic Acid	1986
Diagnosis of argininosuccinic aciduria after valproic acid-induced hyperammonemia. Neurology, 1987, Volume: 37, Issue:5 Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinic Acid; Female; Humans; Male; Metabolic Diseases; Valproic Acid	1987
Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects. Therapeutic drug monitoring, 1987, Volume: 9, Issue:1 Topics: Adolescent; Adult; Alopecia; Ammonia; Body Weight; Child; Epilepsy; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Monitoring, Physiologic; Sleep Stages; Tremor; Valproic Acid	1987
Lack of relationship between sodium valproate-induced adverse effects and the plasma concentration of its metabolite 2-propylpenten-4-oic acid. European journal of clinical pharmacology, 1987, Volume: 32, Issue:2 Topics: Adolescent; Adult; Ammonia; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Humans; Kinetics; Male; Valproic Acid	1987
A trial of discontinuation of barbiturates in patients with secondary generalized epilepsy. The Japanese journal of psychiatry and neurology, 1986, Volume: 40, Issue:4 Topics: Adolescent; Adult; Ammonia; Barbiturates; Child; Child, Preschool; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Male; Valproic Acid	1986
Blood ammonia level during valproic acid therapy. The Japanese journal of psychiatry and neurology, 1986, Volume: 40, Issue:4 Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Liver Function Tests; Male; Middle Aged; Valproic Acid	1986
Salicylate potentiates valproate-induced hyperammonemia in the rat. Pharmacology, 1987, Volume: 34, Issue:5 Topics: 2,4-Dinitrophenol; Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinitrophenols; Drug Synergism; Food; Kinetics; Male; Rats; Rats, Inbred Strains; Salicylates; Salicylic Acid; Valproic Acid	1987
Inhibition of metabolic processes by coenzyme-A-sequestering aromatic acids. Prevention by para-chloro- and para-nitrobenzoic acids. Biochemical pharmacology, 1987, Oct-01, Volume: 36, Issue:19 Topics: 4-Aminobenzoic Acid; Ammonia; Animals; Benzoates; Benzoic Acid; Coenzyme A; Fatty Acids; Glucose; In Vitro Techniques; Liver; Male; Nitrobenzoates; Rats; Salicylates; Salicylic Acid; Valproic Acid	1987
Hepatic and renal contributions to valproic acid-induced hyperammonemia. Neurology, 1988, Volume: 38, Issue:3 Topics: Amino Acids; Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Injections, Intraperitoneal; Kidney; Liver; Male; Nephrectomy; Osmolar Concentration; Rats; Rats, Inbred Strains; Valproic Acid	1988
Valproic acid efficacy, toxicity, and pharmacokinetics in neonates with intractable seizures. Neurology, 1988, Volume: 38, Issue:3 Topics: Absorption; Ammonia; Humans; Infant, Newborn; Osmolar Concentration; Seizures; Valproic Acid	1988
Valproate-induced stimulation of renal ammonia production and excretion in the rat. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1988, Volume: 26, Issue:2 Topics: Ammonia; Animals; Kidney; Male; Rats; Rats, Inbred Strains; Stimulation, Chemical; Valproic Acid	1988
Protective effect of D,L-carnitine on valproate-induced hyperammonemia and hypoketonemia in primary cultured rat hepatocytes. Biochemical pharmacology, 1988, Jun-01, Volume: 37, Issue:11 Topics: Ammonia; Animals; Carnitine; Cells, Cultured; Glutamates; Ketone Bodies; Liver; Male; Rats; Rats, Inbred Strains; Valproic Acid	1988
Ammoniagenesis and valproic acid in the rat in vivo: role of the kidney. Contributions to nephrology, 1988, Volume: 63 Topics: Ammonia; Animals; Glutamine; Kidney; Male; Rats; Rats, Inbred Strains; Valproic Acid	1988
Effect of valproate on renal metabolism in the intact dog. Kidney international, 1988, Volume: 34, Issue:5 Topics: Acid-Base Equilibrium; Acidosis; Ammonia; Animals; Biological Transport; Dogs; Kidney; Kidney Tubules; Lactates; Lactic Acid; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Valproic Acid	1988
Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid. European journal of pediatrics, 1988, Volume: 148, Issue:3 Topics: Adolescent; Amino Acids; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Valproic Acid	1988
[Encephalopathy with asterixis induced by sodium valproate. Role of hyperammonemia without hepatic insufficiency]. Presse medicale (Paris, France : 1983), 1985, Feb-16, Volume: 14, Issue:7 Topics: Ammonia; Brain Diseases; Humans; Male; Middle Aged; Movement Disorders; Valproic Acid	1985
Standardization in VPA-induced hyperammonemia. Neurology, 1985, Volume: 35, Issue:1 Topics: Ammonia; Humans; Valproic Acid	1985
Adaptation of hepatic ammonia metabolism after chronic valproate administration in epileptics treated with phenytoin. European neurology, 1985, Volume: 24, Issue:3 Topics: Adaptation, Physiological; Adult; Ammonia; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Kidney; Liver; Middle Aged; Phenytoin; Valproic Acid	1985
Effect of valproate on brain GABA: comparison with various medium chain fatty acids. Pharmacological research communications, 1985, Volume: 17, Issue:6 Topics: Ammonia; Animals; Anticonvulsants; Brain Chemistry; Fatty Acids; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Valproic Acid	1985
Effect of associated antiepileptic treatment on valproate-induced hyperammonemia. Therapeutic drug monitoring, 1985, Volume: 7, Issue:2 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Drug Interactions; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Time Factors; Valproic Acid	1985
Decrease of valproate-induced hyperammonemia in normal subjects by lipid ingestion. Journal of the neurological sciences, 1985, Volume: 69, Issue:3 Topics: Ammonia; Dietary Fats; Fatty Acids; Humans; Kidney Diseases; Male; Valproic Acid	1985
Valproate-induced hyperammonaemia in two epileptic identical twins. Journal of neurology, 1985, Volume: 232, Issue:3 Topics: Adult; Ammonia; Diseases in Twins; Drug Therapy, Combination; Electroencephalography; Epilepsy, Absence; Evoked Potentials; Humans; Male; Valproic Acid	1985
Chronic valproic acid therapy and incidence of increases in venous plasma ammonia. Therapeutic drug monitoring, 1985, Volume: 7, Issue:3 Topics: Adolescent; Adult; Aged; Ammonia; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Valproic Acid	1985
[Effects of valproate on mitochondrial function in epileptic patients]. No to hattatsu = Brain and development, 1985, Volume: 17, Issue:6 Topics: Adolescent; Ammonia; Carnitine; Child; Child, Preschool; Epilepsy; Humans; Lactates; Lactic Acid; Mitochondria; Valproic Acid	1985
Secondary hyperammonaemia: a possible mechanism for valproate encephalopathy. Lancet (London, England), 1980, Jun-14, Volume: 1, Issue:8181 Topics: Ammonia; Brain; Brain Diseases; Child, Preschool; Epilepsy; Female; Humans; Propionates; Valproic Acid	1980
Valproate, hyperammonaemia, and hyperglycinaemia. Lancet (London, England), 1980, Aug-02, Volume: 2, Issue:8188 Topics: Ammonia; Animals; Glycine; Humans; Rats; Sleep Stages; Valproic Acid	1980
Sodium valproate and ornithine carbamyl transferase deficiency. Lancet (London, England), 1981, May-23, Volume: 1, Issue:8230 Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Humans; Infant; Liver; Male; Mitochondria, Liver; Ornithine Carbamoyltransferase Deficiency Disease; Valproic Acid	1981
[Sodium valproate: a hyperammonemic drug. Study in the epileptic and healthy volunteer]. Journal of the neurological sciences, 1983, Volume: 58, Issue:2 Topics: Ammonia; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy; Feeding Behavior; Humans; Phenobarbital; Valproic Acid	1983
Sodium valproate-induced hyperammonemia in the rat: role of the kidney. European journal of pharmacology, 1983, Feb-18, Volume: 87, Issue:2-3 Topics: Ammonia; Animals; Glutamine; Kidney; Male; Nephrectomy; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid	1983
Acute valproate intoxication: biochemical investigations and hemodialysis treatment. International journal of clinical pharmacology, therapy, and toxicology, 1983, Volume: 21, Issue:2 Topics: Adult; Amino Acids; Ammonia; Carbohydrate Metabolism; Female; Glucose; Humans; Kidney Function Tests; Lipid Metabolism; Liver; Pancreas; Propionates; Renal Dialysis; Time Factors; Valproic Acid	1983
The renal origin of sodium valproate-induced hyperammonemia in fasting humans. Neurology, 1983, Volume: 33, Issue:9 Topics: Adult; Ammonia; Fasting; Female; Humans; Kidney; Male; Middle Aged; Valproic Acid	1983
Reye-like syndrome associated with valproic acid. Brain & development, 1983, Volume: 5, Issue:3 Topics: Adolescent; Ammonia; Biopsy; Female; Humans; Liver; Liver Function Tests; Reye Syndrome; Status Epilepticus; Valproic Acid	1983
Sodium valproate associated with phenobarbital: effects on ammonia metabolism in humans. Epilepsia, 1983, Volume: 24, Issue:5 Topics: Adult; Ammonia; Epilepsy; Female; Humans; Kidney; Liver; Male; Middle Aged; Phenobarbital; Valproic Acid	1983
Valproate-induced hyperammonemia in asymptomatic children. Cleveland Clinic quarterly, 1983,Fall, Volume: 50, Issue:3 Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Liver; Valproic Acid	1983
Treatment of epileptic patients with valproic acid does not modify plasma and urine short-chain-fatty acids. Acta neurologica Scandinavica, 1983, Volume: 68, Issue:4 Topics: Adolescent; Adult; Ammonia; Brain Diseases; Butyrates; Epilepsy; Fatty Acids; Female; Hemiterpenes; Humans; Isobutyrates; Male; Pentanoic Acids; Propionates; Reye Syndrome; Valerates; Valproic Acid	1983
The influence of anticonvulsants on fasting plasma ammonia and amino acid levels. Clinical biochemistry, 1983, Volume: 16, Issue:6 Topics: Amino Acids; Ammonia; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Glutamine; Glycine; Humans; Infant; Ornithine; Phenobarbital; Valproic Acid	1983
[Role of hyperammonemia in stuporous states induced by sodium valproate]. Revue neurologique, 1983, Volume: 139, Issue:12 Topics: Adult; Ammonia; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamine; Humans; Unconsciousness; Valproic Acid	1983
Blood ammonia measurement using a simple reflectometer. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1984, Volume: 22, Issue:1 Topics: Ammonia; Colorimetry; Humans; Liver Diseases; Quality Control; Valproic Acid	1984
Valproic acid-induced hyperammonemia in mentally retarded adults. Neurology, 1984, Volume: 34, Issue:4 Topics: Adolescent; Adult; Aged; Ammonia; Female; Humans; Intellectual Disability; Male; Middle Aged; Valproic Acid	1984
[Case of propionic acidemia]. No to hattatsu = Brain and development, 1984, Volume: 16, Issue:1 Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Female; Humans; Infant; Propionates; Valproic Acid	1984
Hyperammonemia and valproate-induced alterations of the state of consciousness. A report of 8 cases. European neurology, 1984, Volume: 23, Issue:2 Topics: Adult; Ammonia; Epilepsy; Female; Humans; Male; Unconsciousness; Valproic Acid	1984
[Renal glutamine metabolism in man during treatment with sodium valproate]. Revue neurologique, 1984, Volume: 140, Issue:5 Topics: Adult; Ammonia; Female; Glutamine; Humans; Kidney; Male; Middle Aged; Valproic Acid	1984
Valproate-induced hyperammonemia: role of diet. World review of nutrition and dietetics, 1984, Volume: 43 Topics: Ammonia; Diet; Dietary Proteins; Humans; Valproic Acid	1984
Acute changes of blood ammonia may predict short-term adverse effects of valproic acid. Neurology, 1984, Volume: 34, Issue:11 Topics: Adolescent; Adult; Ammonia; Child; Consciousness Disorders; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid	1984
Venous blood ammonia concentrations in adult epileptic patients are increased by treatment with valproic acid. Acta neurologica, 1984, Volume: 6, Issue:6 Topics: Adult; Ammonia; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid	1984
A mechanism for valproate-induced hyperammonemia. Pediatric research, 1981, Volume: 15, Issue:6 Topics: Ammonia; Animals; Rats; Valproic Acid	1981
Hyperammonemia with valproic acid therapy. The Journal of pediatrics, 1981, Volume: 99, Issue:2 Topics: Ammonia; Child; Child, Preschool; Female; Humans; Male; Valproic Acid	1981
Valproic acid and secondary hyperammonemia. Neurology, 1981, Volume: 31, Issue:9 Topics: Ammonia; Child; Child, Preschool; Female; Humans; Infant; Seizures; Valproic Acid	1981
[Isolated hyperammonemia. A frequent consequence of treatment with sodium valproate]. La Nouvelle presse medicale, 1981, Nov-14, Volume: 10, Issue:41 Topics: Ammonia; Humans; Valproic Acid	1981
Hyperammonemia and asterixis with valproic acid. Neurology, 1981, Volume: 31, Issue:12 Topics: Ammonia; Humans; Muscular Diseases; Valproic Acid	1981
Sodium valproate-induced hyperammonemia without clinical hepatic dysfunction. Neurology, 1982, Volume: 32, Issue:2 Topics: Adult; Ammonia; Brain Diseases; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; Female; Humans; Liver Function Tests; Male; Middle Aged; Valproic Acid	1982
Valproate-induced hyperammonemia. Annals of neurology, 1982, Volume: 11, Issue:3 Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Carbamoyl-Phosphate Synthase (Ammonia); Child; Epilepsy; Female; Humans; Ligases; Male; Valproic Acid	1982
Asymptomatic hyperammonemia in patients receiving valproic acid. Archives of neurology, 1982, Volume: 39, Issue:9 Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Humans; Infant; Seizures; Valproic Acid	1982
[Sodium valproate, hyperammonemia and hepatic encephalopathy]. Gastroenterologie clinique et biologique, 1982, Volume: 6, Issue:12 Topics: Ammonia; Hepatic Encephalopathy; Humans; Valproic Acid	1982
A mechanism for valproate-induced hyperammonemia. Advances in experimental medicine and biology, 1982, Volume: 153 Topics: Ammonia; Animals; Citrulline; Glutamates; Male; Mitochondria, Liver; Oxidation-Reduction; Rats; Rats, Inbred Strains; Urea; Valproic Acid	1982
Neurological deterioration in patients with urea cycle disorders under valproate therapy--a cause for concern. European journal of pediatrics, 1995, Volume: 154, Issue:7 Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Child; Epilepsy; Female; Humans; Hyperargininemia; Neurologic Examination; Risk Factors; Valproic Acid	1995
Valproic acid-associated encephalopathy with coma. The American journal of psychiatry, 1995, Volume: 152, Issue:8 Topics: Ammonia; Coma; Female; Humans; Middle Aged; Paralysis; Valproic Acid	1995
Valproic acid-induced hyperammonemic encephalopathy: MR appearance. AJNR. American journal of neuroradiology, 1994, Volume: 15, Issue:9 Topics: Adult; Ammonia; Atrophy; Brain Diseases, Metabolic; Cerebral Cortex; Diagnosis, Differential; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Valproic Acid	1994
Valproate as a cause of hyperammonemia in heterozygotes with ornithine-transcarbamylase deficiency. Neurology, 1995, Volume: 45, Issue:3 Pt 1 Topics: Ammonia; Child; Epilepsy, Tonic-Clonic; Female; Heterozygote; Humans; Ornithine Carbamoyltransferase Deficiency Disease; Valproic Acid	1995
Effect of valproate and of two of its metabolites on renal substrate uptake and ammoniagenesis in the rat in vivo. Contributions to nephrology, 1994, Volume: 110 Topics: Ammonia; Animals; Fatty Acids, Monounsaturated; Kidney; Male; Rats; Valproic Acid	1994
[Hyperammonemic encephalopathy caused by sodium valproate]. La Revue de medecine interne, 1994, Volume: 15, Issue:5 Topics: Aged; Ammonia; Coma; Female; Humans; Valproic Acid	1994
Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient. Annals of emergency medicine, 1993, Volume: 22, Issue:3 Topics: Adult; Ammonia; Epilepsy, Complex Partial; Humans; Male; Metabolic Diseases; Valproic Acid	1993
Ammonia-independent modifications of the background EEG signal and paradoxical enhancement of epileptic abnormalities in EEG after acute administration of valproate to epileptic patients. Neuropharmacology, 1993, Volume: 32, Issue:9 Topics: Adolescent; Adult; Ammonia; Arousal; Blood Glucose; Blood Pressure; Electroencephalography; Epilepsy; Female; Heart Rate; Humans; Male; Valproic Acid	1993
[Encephalopathy associated with hyperammonemia in an alcoholic patient treated with sodium valproate]. Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:6-7 Topics: Ammonia; Brain Diseases; Drug Therapy, Combination; Humans; Male; Middle Aged; Phenobarbital; Psychoses, Alcoholic; Valproic Acid	1993
Effect of valproate, sodium 2-propyl-4-pentenoate and sodium 2-propyl-2-pentenoate on renal substrate uptake and ammoniagenesis in the rat. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1 Topics: Ammonia; Animals; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Glomerular Filtration Rate; Ketone Bodies; Kidney; Male; Rats; Rats, Wistar; Renal Circulation; Stimulation, Chemical; Urodynamics; Valproic Acid	1993
Carbamoylphosphate synthetase deficiency in an adult: deterioration due to administration of valproic acid. Journal of inherited metabolic disease, 1993, Volume: 16, Issue:1 Topics: Adult; Alanine; Ammonia; Blood Urea Nitrogen; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Electrophoresis, Polyacrylamide Gel; Female; Humans; Liver; Urea; Valproic Acid	1993
Effect of L-carnitine supplementation on acute valproate intoxication. Epilepsia, 1996, Volume: 37, Issue:7 Topics: Ammonia; Carnitine; Coma; Drug Overdose; Epilepsy; Humans; Infant; Male; Oxidation-Reduction; Valproic Acid	1996
Carnitine for valproic acid-induced hyperammonemia. The American journal of psychiatry, 1997, Volume: 154, Issue:8 Topics: Adult; Ammonia; Bipolar Disorder; Carbamoyl-Phosphate Synthase (Ammonia); Carnitine; Depressive Disorder; Drug Administration Schedule; Female; Humans; Urea; Valproic Acid	1997
Diet- and valproate-induced transient hyperammonemia: effect of L-carnitine. Pediatric neurology, 1997, Volume: 16, Issue:4 Topics: Administration, Oral; Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Diet; Epilepsy; Female; Humans; Male; Prospective Studies; Valproic Acid	1997
[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients]. Revista de neurologia, 1997, Volume: 25, Issue:143 Topics: Adolescent; Amino Acids; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Glutamine; Glycine; Humans; Infant; Infant, Newborn; Ornithine; Prospective Studies; Retrospective Studies; Urea; Valproic Acid	1997
Asymptomatic hyperammonemia in children treated with valproic acid. Journal of child neurology, 1997, Volume: 12, Issue:7 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Liver Diseases; Male; Valproic Acid	1997
Valproate therapy does not deplete carnitine levels in otherwise healthy children. Pediatrics, 1998, Volume: 101, Issue:5 Topics: Adolescent; Adult; Ammonia; Carnitine; Case-Control Studies; Child; Epilepsy; Female; Humans; Male; Reference Values; Valproic Acid	1998
Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency. Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 64, Issue:5 Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Diagnosis, Differential; Drug Therapy, Combination; Epilepsy, Complex Partial; Female; Genetic Carrier Screening; Humans; Ornithine Carbamoyltransferase Deficiency Disease; Valproic Acid	1998
Valproate-induced epileptic tonic status. Seizure, 1998, Volume: 7, Issue:3 Topics: Adolescent; Ammonia; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Male; Phenobarbital; Status Epilepticus; Valproic Acid	1998
Fatal hyperammonemia in a patient with systemic lupus erythematosus. Internal medicine (Tokyo, Japan), 1998, Volume: 37, Issue:8 Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Fatal Outcome; Female; Humans; Kidney Failure, Chronic; Lupus Erythematosus, Systemic; Nephrotic Syndrome; Risk Factors; Seizures; Valproic Acid	1998
Hyperammonemia and coma developed by a woman treated with valproic acid for affective disorder. Psychiatric services (Washington, D.C.), 1998, Volume: 49, Issue:10 Topics: Aged; Ammonia; Anticonvulsants; Coma; Female; Humans; Mood Disorders; Valproic Acid	1998
L-carnitine supplementation in childhood epilepsy: current perspectives. Epilepsia, 1998, Volume: 39, Issue:11 Topics: Age Factors; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Food, Formulated; Humans; Infant; Valproic Acid	1998
A case of severe hyperammonemia and unconsciousness following sodium valproate intoxication. Veterinary and human toxicology, 1998, Volume: 40, Issue:6 Topics: Adolescent; Ammonia; Anion Exchange Resins; Anticonvulsants; Cholestyramine Resin; Drug Overdose; Humans; Hypernatremia; Male; Suicide, Attempted; Treatment Outcome; Unconsciousness; Valproic Acid	1998
[Encephalopathies caused by valproate]. Fortschritte der Neurologie-Psychiatrie, 1999, Volume: 67, Issue:1 Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Drug Interactions; Epilepsy; Humans; Middle Aged; Valproic Acid	1999
Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. International journal of clinical & laboratory research, 1999, Volume: 29, Issue:1 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Metabolic Diseases; Valproic Acid	1999
Valproate-induced hyperammonemia in the psychiatric setting: 2 cases. The Journal of clinical psychiatry, 1999, Volume: 60, Issue:8 Topics: Adult; Ammonia; Anticonvulsants; Bipolar Disorder; Humans; Male; Mental Disorders; Middle Aged; Psychotic Disorders; Valproic Acid	1999
Inhibitory effect of valproate on weak organic acid uptake in rat renal proximal tubules. Biochemical pharmacology, 1999, Oct-15, Volume: 58, Issue:8 Topics: Ammonia; Animals; Anticonvulsants; Fluorescein; Glutamic Acid; Glutamine; Kidney Tubules, Proximal; Male; Rats; Rats, Wistar; Valproic Acid	1999
Partial N-acetyl-glutamate synthetase deficiency masquerading as a valproic acid-induced Reye-like syndrome. Acta paediatrica (Oslo, Norway : 1992), 1999, Volume: 88, Issue:12 Topics: Ammonia; Child, Preschool; Glutamate Synthase; Humans; Liver Function Tests; Male; Reye Syndrome; Valproic Acid	1999
Valproate-induced hyperammonemic encephalopathy in the presence of topiramate. Neurology, 2000, Jan-11, Volume: 54, Issue:1 Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Drug Therapy, Combination; Electroencephalography; Epilepsy; Female; Fructose; Humans; Male; Topiramate; Valproic Acid	2000
[A case report of valproate encephalopathy]. Rinsho shinkeigaku = Clinical neurology, 1999, Volume: 39, Issue:10 Topics: Adult; Ammonia; Anticonvulsants; Biomarkers; Brain; Brain Diseases; Carnitine; Epilepsy; Female; Humans; Mitochondria; Valproic Acid	1999
Valproic acid-induced hyperammonemic encephalopathy with triphasic waves. Epilepsia, 2000, Volume: 41, Issue:7 Topics: Amino Acids; Ammonia; Brain Diseases, Metabolic; Electroencephalography; Humans; Male; Middle Aged; Valproic Acid	2000
Hyperlactatemia and hyperammonemia as secondary effects of valproic acid poisoning. The American journal of emergency medicine, 2000, Volume: 18, Issue:4 Topics: Adolescent; Ammonia; Fatal Outcome; Female; Humans; Lactic Acid; Suicide; Valproic Acid	2000
Valproate-induced hyperammonemic encephalopathy in the presence of topiramate. Neurology, 2000, Aug-22, Volume: 55, Issue:4 Topics: Adolescent; Ammonia; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Female; Fructose; Humans; Neurotoxicity Syndromes; Receptors, GABA-A; Seizures; Topiramate; Valproic Acid	2000
[Hyperammonia, hypoglycemia and thrombocytopenia in a newborn after materanl treatment with valproate]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2001, Volume: 8, Issue:4 Topics: Adult; Ammonia; Anticonvulsants; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Thrombocytopenia; Valproic Acid	2001
Valproate-induced encephalopathy. Zhonghua yi xue za zhi = Chinese medical journal; Free China ed, 2001, Volume: 64, Issue:8 Topics: Ammonia; Anticonvulsants; Brain Diseases; Electroencephalography; Female; Humans; Middle Aged; Valproic Acid	2001
Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy. Epilepsia, 2002, Volume: 43, Issue:2 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Brain; Brain Diseases; Electroencephalography; Female; Glutamine; Humans; Hyperammonemia; Male; Middle Aged; Valproic Acid	2002
Fulminant progression of hyperammonaemic encephalopathy after treatment with valproate in a patient with ureterosigmoidostomy. Journal of neurology, neurosurgery, and psychiatry, 2002, Volume: 73, Issue:1 Topics: Adult; Ammonia; Anastomosis, Surgical; Anticonvulsants; Brain Diseases, Metabolic; Colon, Sigmoid; Fatal Outcome; Humans; Hyperammonemia; Intestinal Absorption; Male; Urinary Diversion; Valproic Acid	2002
Delayed absorption of valproic acid, resulting in coma. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2002, Volume: 9, Issue:12 Topics: Adult; Ammonia; Coma; Humans; Male; Time Factors; Valproic Acid	2002
Valproate-induced hyperammonemic encephalopathy. Epilepsia, 2003, Volume: 44, Issue:2 Topics: Ammonia; Anticonvulsants; Basal Ganglia Diseases; Brain Diseases, Metabolic; Diagnosis, Differential; Follow-Up Studies; Globus Pallidus; Humans; Hyperammonemia; Remission, Spontaneous; Valproic Acid	2003
Neurotoxicity following addition of intravenous valproate to lamotrigine therapy. Neurology, 2003, Jun-24, Volume: 60, Issue:12 Topics: Administration, Oral; Adult; Ammonia; Anticonvulsants; Confusion; Drug Interactions; Drug Therapy, Combination; Epilepsy, Absence; Epilepsy, Generalized; Female; Glucuronosyltransferase; Humans; Inactivation, Metabolic; Injections, Intravenous; Lamotrigine; Middle Aged; Status Epilepticus; Triazines; Valproic Acid	2003
Carnitine. Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:6 Topics: Ammonia; Anticonvulsants; Carnitine; Humans; Valproic Acid	2003
Role of carnitine in valproic acid toxicity. Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:6 Topics: Ammonia; Anticonvulsants; Carnitine; Humans; Valproic Acid	2003
Drug induced encephalopathy in six epileptic patients: topiramate? valproate? or both? Human psychopharmacology, 2004, Volume: 19, Issue:3 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Electroencephalography; Epilepsy; Female; Fructose; Humans; Male; Neurotoxicity Syndromes; Topiramate; Valproic Acid	2004
Valproic acid-induced hyperammonemia and thrombocytopenia in an elderly woman. The Annals of pharmacotherapy, 2004, Volume: 38, Issue:10 Topics: Aged; Ammonia; Anticonvulsants; Female; Humans; Hyperammonemia; Platelet Count; Thrombocytopenia; Valproic Acid	2004
Valproic acid-induced hyperammonemia: a case report. Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:5 Topics: Ammonia; Anticonvulsants; Blood Urea Nitrogen; Consciousness Disorders; Diagnosis, Differential; Drug Therapy, Combination; Epilepsy, Post-Traumatic; Female; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver Function Tests; Mental Status Schedule; Middle Aged; Valproic Acid	2004
Characteristics of glutamine metabolism in human precision-cut kidney slices: a 13C-NMR study. The Biochemical journal, 2005, May-01, Volume: 387, Issue:Pt 3 Topics: Ammonia; Carbon Isotopes; Dose-Response Relationship, Drug; Glucose; Glutamine; Humans; Kidney; Lactic Acid; Magnetic Resonance Spectroscopy; Valproic Acid	2005
Fatal cerebral edema after moderate valproic acid overdose. Annals of emergency medicine, 2005, Volume: 45, Issue:3 Topics: Adult; Ammonia; Brain Edema; Cyclohexanols; Drug Overdose; Fatal Outcome; Humans; Male; Risperidone; Valproic Acid; Venlafaxine Hydrochloride	2005
Two cases of valproate-induced hyperammonemic encephalopathy without hepatic failure. The Journal of the Association of Physicians of India, 2004, Volume: 52 Topics: Ammonia; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Fructose; Humans; Hyperammonemia; Male; Neurotoxicity Syndromes; Seizures; Topiramate; Valproic Acid	2004
Non-convulsive status epilepticus secondary to valproic acid-induced hyperammonemic encephalopathy. Acta neurologica Scandinavica, 2007, Volume: 116, Issue:2 Topics: Adult; Ammonia; Anticonvulsants; Brain; Electroencephalography; Hepatic Encephalopathy; Humans; Hyperammonemia; Liver; Male; Midazolam; Phenytoin; Status Epilepticus; Valproic Acid	2007
Massive valproic acid overdose, a misleading case. The American journal of emergency medicine, 2008, Volume: 26, Issue:1 Topics: Adult; Ammonia; Anticonvulsants; Antidotes; Charcoal; Coma; Drug Overdose; Epilepsy; Humans; Male; Poisoning; Respiratory Insufficiency; Suicide, Attempted; Valproic Acid	2008
The measurement of ammonia blood levels in patients taking valproic acid: looking for problems where they do not exist? Epilepsy & behavior : E&B, 2008, Volume: 12, Issue:3 Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Valproic Acid	2008
[Metabolic encephalopathy can be a potentially life-threatening complication from valproic acid]. Nederlands tijdschrift voor geneeskunde, 2008, Feb-02, Volume: 152, Issue:5 Topics: Aged, 80 and over; Ammonia; Brain Diseases, Metabolic; Consciousness Disorders; Diagnosis, Differential; Female; Humans; Hyperammonemia; Middle Aged; Valproic Acid	2008
Adjunctive topiramate enhances the risk of hypothermia associated with valproic acid therapy. Journal of clinical pharmacy and therapeutics, 2008, Volume: 33, Issue:5 Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Algorithms; Ammonia; Anticonvulsants; Bicarbonates; Child; Child, Preschool; Databases, Factual; Drug Interactions; Female; Fructose; Humans; Hypothermia; Male; Middle Aged; Retrospective Studies; Topiramate; United States; United States Food and Drug Administration; Valproic Acid; Young Adult	2008
Valproate-induced hyperammonemic encephalopathy. Pediatrics and neonatology, 2008, Volume: 49, Issue:5 Topics: Adolescent; Ammonia; Brain Diseases, Metabolic; Female; Humans; Seizures; Valproic Acid	2008
Serum biotinidase activity in children treated with valproic acid and carbamazepine. Journal of child neurology, 2010, Volume: 25, Issue:1 Topics: Alanine Transaminase; Ammonia; Anticonvulsants; Aspartate Aminotransferases; Biotinidase; Carbamazepine; Child; Female; gamma-Glutamyltransferase; Hair; Humans; Hyperammonemia; Liver; Seizures; Sex Characteristics; Valproic Acid	2010
Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. carnitine and glucose/thiamine. Scandinavian journal of gastroenterology, 2010, Volume: 45, Issue:6 Topics: Aged; Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Carnitine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Glucose; Humans; Injections, Intravenous; Sweetening Agents; Thiamine; Time Factors; Valproic Acid; Vitamin B Complex	2010
Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children. Brain & development, 2011, Volume: 33, Issue:3 Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Half-Life; Humans; Infant; Infusions, Intravenous; Male; Recurrence; Seizures; Status Epilepticus; Thailand; Valproic Acid	2011
Blood ammonia levels in epileptic children on 2 dose ranges of valproic acid monotherapy: a cross-sectional study. Journal of child neurology, 2011, Volume: 26, Issue:1 Topics: Ammonia; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fluorescence Polarization Immunoassay; Humans; Infant; Kidney Function Tests; Valproic Acid	2011
Rise in brain GABA to further stress the metabolic link between valproate and creatine. Molecular genetics and metabolism, 2011, Volume: 102, Issue:2 Topics: Ammonia; Autistic Disorder; Brain; Creatine; Humans; Valproic Acid	2011
New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA. Journal of hepatology, 2011, Volume: 55, Issue:2 Topics: Acyl Coenzyme A; Amino-Acid N-Acetyltransferase; Ammonia; Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Glutamates; Glutamine; Humans; Hyperammonemia; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Wistar; Urea; Valproic Acid	2011
A case of valproate-induced encephalopathy. The Australian and New Zealand journal of psychiatry, 2012, Volume: 46, Issue:12 Topics: Ammonia; Antimanic Agents; Brain Diseases, Metabolic; Female; Humans; Hyperammonemia; Middle Aged; Psychotic Disorders; Treatment Outcome; Valproic Acid; Withholding Treatment	2012
Correlation between plasma ammonia level and serum trough concentration of free valproic acid in patients with epilepsy. Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:6 Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Asian People; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Valproic Acid; Young Adult	2012
Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity. BMJ case reports, 2014, Apr-15, Volume: 2014 Topics: Adrenocorticotropic Hormone; Ammonia; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Female; Humans; Infant; Liver Function Tests; Neurotoxicity Syndromes; Spasms, Infantile; Valproic Acid	2014
Hyperammonemia associated with valproic acid concentrations. BioMed research international, 2014, Volume: 2014 Topics: Adolescent; Adult; Ammonia; Bipolar Disorder; Carnitine; Child; Dietary Supplements; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hyperammonemia; Male; Middle Aged; Mitochondria; Saliva; Valproic Acid; Young Adult	2014
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. Epilepsy research, 2014, Volume: 108, Issue:6 Topics: Alleles; Amino-Acid N-Acetyltransferase; Ammonia; Anticonvulsants; Asian People; Biomarkers, Pharmacological; Carbamoyl-Phosphate Synthase (Ammonia); Child; Epilepsy; Female; Genetic Predisposition to Disease; Humans; Hyperammonemia; Japan; Male; Phenytoin; Polymorphism, Single Nucleotide; Risk Factors; Valproic Acid	2014
Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy. Medicine, 2014, Volume: 93, Issue:11 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ammonia; Anticonvulsants; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Humans; Hyperammonemia; Liver; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Valproic Acid; Young Adult	2014
Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. Seizure, 2015, Volume: 33 Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Glutamate-Ammonia Ligase; Humans; Hyperammonemia; Infant; Infant, Newborn; Logistic Models; Male; Phenytoin; Polymorphism, Genetic; Sex Factors; Valproic Acid	2015
L-Arginine in the treatment of valproate overdose - five clinical cases. Clinical toxicology (Philadelphia, Pa.), 2017, Volume: 55, Issue:4 Topics: Acyl Coenzyme A; Adult; Amino-Acid N-Acetyltransferase; Ammonia; Arginine; Carnitine; Coma; Drug Overdose; Female; Humans; Hyperammonemia; Male; Renal Dialysis; Valproic Acid	2017
Gait instability in valproate-treated patients: Call to measure ammonia levels. Acta neurologica Scandinavica, 2017, Volume: 136, Issue:5 Topics: Accidental Falls; Adult; Ammonia; Anticonvulsants; Disease Progression; Epilepsy, Frontal Lobe; Female; Gait Disorders, Neurologic; Humans; Hyperammonemia; Male; Valproic Acid	2017
Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy. Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:5 Topics: Age Factors; Ammonia; Anticonvulsants; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; China; Chromatography, Liquid; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Hyperammonemia; Infant; Male; Pharmacogenomic Testing; Risk Factors; Tandem Mass Spectrometry; Valproic Acid	2018
A 33-Year-Old Woman With Altered Mental Status and Elevated Ammonia Level. Chest, 2018, Volume: 154, Issue:6 Topics: Adult; Ammonia; Anticonvulsants; Arrhythmias, Cardiac; Drug Overdose; Female; Glasgow Coma Scale; Humans; Mental Disorders; Renal Dialysis; Respiration, Artificial; Seizures; Treatment Outcome; Valproic Acid	2018
Valproicacid-induced hyperammonemic encephalopathy in the emergency department. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias, 2019, Volume: 31, Issue:5 Topics: Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Female; Humans; Hyperammonemia; Middle Aged; Reference Values; Valproic Acid	2019
Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder. Therapeutic drug monitoring, 2020, Volume: 42, Issue:5 Topics: Ammonia; Anticonvulsants; Bipolar Disorder; Carnitine; Epilepsy; Female; Humans; Male; Middle Aged; Retrospective Studies; Valproic Acid	2020
Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity. Psychiatric genetics, 2021, 02-01, Volume: 31, Issue:1 Topics: Adult; Amino Acid Substitution; Ammonia; Animals; Anticonvulsants; Autistic Disorder; Bipolar Disorder; Citrates; Dicarboxylic Acid Transporters; Drosophila Proteins; Epilepsy; Female; Food Deprivation; Heterozygote; Humans; Lactates; Longevity; Metformin; Mice; Mutation, Missense; Point Mutation; Psychotic Disorders; Psychotropic Drugs; Pyruvates; Recurrence; Spasms, Infantile; Symporters; Tooth Abnormalities; Valproic Acid	2021
Hyperammonemia in Patients With Status Epilepticus Treated With or Without Valproic Acid. The neurologist, 2021, May-05, Volume: 26, Issue:3 Topics: Adult; Ammonia; Anticonvulsants; Humans; Hyperammonemia; Status Epilepticus; Valproic Acid	2021
Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. Medicine, 2022, Jul-01, Volume: 101, Issue:26 Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Lamotrigine; Risk Factors; Seizures; Triazines; Valproic Acid	2022
HYPERAMMONAEMIA AND COGNITIVE IMPAIRMENT IN EPILEPSY PATIENTS TREATED WITH VALPROIC ACID - PRELIMINARY STUDY. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2022, Volume: 75, Issue:6 Topics: Ammonia; Anticonvulsants; Cognitive Dysfunction; Dementia; Epilepsy; Female; Humans; Hyperammonemia; Male; Quality of Life; Valproic Acid	2022
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey. Psychopharmacology, 2023, Volume: 240, Issue:1 Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid	2023
Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2023, Apr-01, Volume: 183 Topics: Ammonia; Anticonvulsants; Carnitine; Dietary Supplements; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Hyperammonemia; Network Pharmacology; Valproic Acid	2023
Valproate-induced hyperammonemic encephalopathy treated by L-ornithine-L-aspartate: a case report. Clinical medicine (London, England), 2023, Volume: 23, Issue:3 Topics: Ammonia; Anticonvulsants; Brain Diseases; Humans; Male; Middle Aged; Valproic Acid	2023