valproic acid has been researched along with acetylcysteine in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 12 (41.38) | 29.6817 |
| 2010's | 14 (48.28) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Baillie, TA; Davis, MR; Grillo, MP; Hu, P; Jin, L; Kassahun, K | 1 |
| Abbott, FS; Farrell, K; Gopaul, SV | 2 |
| Johanssen, S; Klee, S; Ungemach, FR | 1 |
| Abbott, F; Farrell, K; Gopaul, S | 1 |
| Cai, YQ; Du, MX; Jiang, XD; Kang, DZ; Ke, YQ; Lin, YX; Qin, LS; Xu, RX | 1 |
| Devi, PU; Pillai, KK; Vohora, D | 1 |
| Pillai, KK; Uma Devi, P; Vohora, D | 1 |
| Kang, DY; Kim, SH; Kim, TH; Park, KJ; Park, MK; Suh, H; Yoo, YH | 1 |
| Ha, H; Kim, YO; Lee, HB; Noh, H; Oh, EY; Seo, JY; Yu, MR | 1 |
| El-Agamy, DS; Said, SA | 1 |
| Hsieh, CL; Peng, CC; Peng, RY; Tsai, WJ; Wang, HE | 1 |
| Blom, H; Frisch, C; Linnebank, M; Semmler, A; Smith, D | 1 |
| Amathieu, R; Chemit, M; Compagnon, P; Costentin, C; Dhonneur, G; Levesque, E; Merle, JC | 1 |
| Chen, KC; Ding, CY; Hsieh, CL; Peng, CC; Tsai, WJ; Wu, JF | 1 |
| Baumgartner, WA; Beaty, CA; Blue, ME; Johnston, MV; Kambhampati, SP; Kannan, RM; Kannan, S; Lesniak, WG; Mishra, MK; Troncoso, JC; Wilson, MA; Zhang, F | 1 |
| Crum, WR; Dexter, DT; Harrison, IF; Vernon, AC | 1 |
| Anis, HK; Dexter, DT; Harrison, IF | 1 |
| Cui, W; Wen, X; Zhai, Q; Zhang, T; Zhang, Y | 1 |
| Anstey, M; Murray, R; Triplett, KE | 1 |
| Deng, YN; He, XL; Li, YF; Wang, LJ; Wang, T; Zhang, YH | 1 |
2 review(s) available for valproic acid and acetylcysteine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Cholestasis; Combined Modality Therapy; Diagnosis, Differential; Disease Management; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Illicit Drugs; Liver Failure, Acute; Liver Function Tests; Liver Transplantation; Mushroom Poisoning; Neurologic Examination; Occupational Diseases; Respiratory Insufficiency; Sepsis; Shock; Time Factors; Valproic Acid | 2013 |
27 other study(ies) available for valproic acid and acetylcysteine
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
Topics: Acetylcysteine; Animals; Biotransformation; Chromatography, Liquid; Coenzyme A; Fatty Acids, Monounsaturated; Glutathione; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Triglycerides; Valproic Acid | 1994 |
Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals.
Topics: Acetylcysteine; Animals; Biotransformation; Chromatography, Liquid; Esters; Guinea Pigs; Humans; Hydrolysis; Mass Spectrometry; Rats; Valproic Acid | 2000 |
Gas chromatography/negative ion chemical ionization mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry quantitative profiling of N-acetylcysteine conjugates of valproic acid in urine: application in drug metabolis
Topics: Acetylcysteine; Adolescent; Analysis of Variance; Animals; Anticonvulsants; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Rats; Valproic Acid | 2000 |
Evidence for a trigger function of valproic acid in xenobiotic-induced hepatotoxicity.
Topics: Acetylcysteine; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Animals; Anticonvulsants; Cells, Cultured; Drug Interactions; Free Radical Scavengers; Glutathione; Liver; Male; Oxidative Stress; Propanols; Rats; Rats, Wistar; Valproic Acid | 2000 |
Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA.
Topics: Acetylcysteine; Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Humans; Liver Diseases; Male; Risk Factors; Valproic Acid | 2003 |
[Effect of N-acetyl-cysteine and depakine pretreatment on ferrous chloride-induced membrane potential and peroxidate changes in rat cortex neurons].
Topics: Acetylcysteine; Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Female; Ferrous Compounds; Male; Membrane Potentials; Neurons; Neuroprotective Agents; Peroxides; Rats; Rats, Sprague-Dawley; Valproic Acid | 2006 |
Facilitation action of N-acetylcysteine on the anticonvulsant effect of sodium valproate in mice.
Topics: Acetylcysteine; Animals; Anticonvulsants; Cerebral Cortex; Drug Synergism; Electroshock; Free Radical Scavengers; Lipid Peroxidation; Male; Mice; Seizures; Valproic Acid | 2006 |
Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Anticonvulsants; Antioxidants; Aspartate Aminotransferases; Brain; Disease Models, Animal; Drug Therapy, Combination; Glutathione; Kidney; Liver; Mice; Oxidative Stress; Pentylenetetrazole; Seizures; Thiobarbituric Acid Reactive Substances; Valproic Acid | 2006 |
Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Cell Survival; Chenodeoxycholic Acid; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mitochondria; Thyroid Neoplasms; Treatment Outcome; Tumor Cells, Cultured; Valproic Acid | 2009 |
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
Topics: Acetylcysteine; Amides; Animals; Antioxidants; Biphenyl Compounds; Cell Line; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Kidney; Male; Mice; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recombinant Proteins; Repressor Proteins; RNA Interference; RNA, Messenger; Transforming Growth Factor beta1; Valproic Acid | 2009 |
Prevention of sodium valproate-induced hepatotoxicity by curcumin, rosiglitazone and N-acetylcysteine in rats.
Topics: Acetylcysteine; Animals; Anticonvulsants; Body Weight; Chemical and Drug Induced Liver Injury; Convulsants; Curcumin; Eating; Fatty Liver; Free Radical Scavengers; Hypoglycemic Agents; Liver; Liver Function Tests; Male; Mice; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rosiglitazone; Seizures; Thiazolidinediones; Valproic Acid | 2010 |
Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, and N-acetylcysteine in chicken embryo model.
Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Chick Embryo; Chromatography, High Pressure Liquid; Folic Acid; Foot Deformities; Glutathione; Hindlimb; Histone Deacetylases; Homocysteine; Hydrogen Peroxide; Joints; Muscle, Skeletal; Neovascularization, Physiologic; Superoxide Dismutase; Teratogens; Tissue Embedding; Valproic Acid; Vitamins | 2012 |
The ratio of S-adenosylmethione and S-adenosyl-homocysteine is increased in the brains of newborn rats in a model of valproic acid teratogenicity.
Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Ascorbic Acid; Folic Acid; Teratogens; Valproic Acid; Vitamins | 2012 |
Valproic acid substantially downregulated genes folr1, IGF2R, RGS2, COL6A3, EDNRB, KLF6, and pax-3, N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model.
Topics: Acetylcysteine; Animals; Avian Proteins; Chick Embryo; Chromatography, High Pressure Liquid; Collagen Type VI; Dose-Response Relationship, Drug; Down-Regulation; Folate Receptor 1; Folic Acid; Gene Expression Regulation, Developmental; Histone Deacetylases; Kruppel-Like Transcription Factors; Models, Biological; Neovascularization, Pathologic; Neural Tube Defects; Oligonucleotide Array Sequence Analysis; Paired Box Transcription Factors; Receptor, IGF Type 2; Receptors, Endothelin; RGS Proteins; Valproic Acid | 2013 |
Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest.
Topics: Acetylcysteine; Animals; Biological Transport; Brain; Brain Injuries; Circulatory Arrest, Deep Hypothermia Induced; Dendrimers; Disease Models, Animal; Dogs; Drug Carriers; Male; Microglia; Nanomedicine; Neurons; Rabbits; Treatment Outcome; Valproic Acid | 2014 |
Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors.
Topics: Acetylation; Acetylcysteine; Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dopaminergic Neurons; Glial Cell Line-Derived Neurotrophic Factor; Histone Deacetylase Inhibitors; Histones; Male; Neuroprotective Agents; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Up-Regulation; Valproic Acid | 2015 |
Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate.
Topics: Acetylcysteine; Animals; Dopaminergic Neurons; Male; Neuroprotective Agents; Parkinsonian Disorders; Proteasome Inhibitors; Rats, Sprague-Dawley; Substantia Nigra; Valproic Acid; Ventral Tegmental Area | 2016 |
N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism.
Topics: Acetylcysteine; Animals; Antioxidants; Autistic Disorder; Behavior, Animal; beta Catenin; Brain; Glutathione; Glycogen Synthase Kinase 3 beta; Male; Malondialdehyde; Oxidative Stress; Phosphorylation; Rats; Rats, Sprague-Dawley; Valproic Acid; Wnt Signaling Pathway | 2017 |
Multifactorial non-cirrhotic hyperammonaemic encephalopathy.
Topics: Acetylcysteine; Aftercare; Anti-Bacterial Agents; Bacteremia; Carnitine; Female; Free Radical Scavengers; Humans; Hyperammonemia; Klebsiella pneumoniae; Magnetic Resonance Imaging; Middle Aged; Neurotoxicity Syndromes; Treatment Outcome; Urinary Tract Infections; Valproic Acid | 2018 |
N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity.
Topics: Acetylcysteine; Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Neuroblastoma; Prenatal Exposure Delayed Effects; Rats; Valproic Acid | 2023 |