valproic acid has been researched along with acetaminophen in 48 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (10.42) | 18.7374 |
1990's | 4 (8.33) | 18.2507 |
2000's | 17 (35.42) | 29.6817 |
2010's | 19 (39.58) | 24.3611 |
2020's | 3 (6.25) | 2.80 |
Authors | Studies |
---|---|
Strassburg, CP; Tukey, RH | 1 |
Topliss, JG; Yoshida, F | 1 |
Chang, TK; Ensom, MH; Kiang, TK | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
Glen, RC; Lowe, R; Mitchell, JB | 1 |
Ekins, S; Williams, AJ; Xu, JJ | 1 |
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Richens, A | 1 |
Støttum, A; Wiger, R | 1 |
Lauterburg, BH | 1 |
Kolts, BE; Langfitt, M | 1 |
Kapetanović, IM; Kupferberg, HJ; Porter, RJ; Theodore, W | 1 |
Chyka, PA; Holley, JE; Mandrell, TD; Sugathan, P | 1 |
Kitteringham, NR; Park, BK; Pirmohamed, M | 1 |
Annoni, JM; Higelin, F | 1 |
Abbott, FS; Tabatabaei, AR; Thies, RL | 1 |
Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M | 1 |
Bailey, DN; Briggs, JR | 1 |
Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS | 1 |
Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ | 1 |
Goldfarb, DS; Hoffman, RS; Holubek, WJ; Nelson, LS | 1 |
Lim, YC | 1 |
Kasuya, F; Kazumi, M; Masuyama, T; Nishizawa, R | 1 |
Bergh, JJ; Kotze, HF; Mienie, LJ; Terre'Blanche, G; Viljoen, J | 1 |
Fey, SJ; Wrzesinski, K | 1 |
Amathieu, R; Chemit, M; Compagnon, P; Costentin, C; Dhonneur, G; Levesque, E; Merle, JC | 1 |
Hendrickson, RG; Lopez, AM | 1 |
Ahmed Bijle, MN; Kamath, A; Kontham, U; Muchandi, S; Nankar, M; Walimbe, H | 1 |
Ambroso, JI; Brown, HR; Falls, JG; Hunt, CM; Ilic, K; Miller, RT; Reese, MJ; Suzuki, A; Yuen, NA | 1 |
Adroja, B; Parekh, H; Prakash, S | 1 |
Hengstler, JG; Vinken, M | 1 |
Audouze, K; El M'Selmi, W; Taboureau, O | 1 |
Castell, JV; García-Llorens, G; Méndez, R; Moreno-Torres, M; Moro, E; Quintás, G | 1 |
Ballók, R; Erdélyi, P; Fischer, J; Kis Varga, Á | 1 |
11 review(s) available for valproic acid and acetaminophen
Article | Year |
---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Interactions with antiepileptic drugs.
Topics: Acetaminophen; Acetazolamide; Anti-Anxiety Agents; Anticoagulants; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Furosemide; Gonadal Steroid Hormones; Griseofulvin; Humans; Phenobarbital; Phenytoin; Primidone; Thiazines; Urea; Valproic Acid; Vitamin D | 1977 |
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics].
Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Glutathione; Halothane; Humans; Isoniazid; Liver; Perhexiline; Valproic Acid | 1985 |
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Hematologic Diseases; Humans; Lung Diseases; Nervous System Diseases; Tacrine; Valproic Acid | 1995 |
Medical treatment of migraine: from mechanisms of action to contraindications.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium Channel Blockers; Female; Humans; Male; Migraine Disorders; Serotonin Receptor Agonists; Valproic Acid | 1998 |
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)].
Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psychology; Child; Flunarizine; GABA Agents; Headache; Humans; Ibuprofen; Metoprolol; Migraine Disorders; Practice Guidelines as Topic; Propranolol; Relaxation Therapy; Serotonin Receptor Agonists; Sumatriptan; Tension-Type Headache; Valproic Acid; Vasodilator Agents | 2002 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Cholestasis; Combined Modality Therapy; Diagnosis, Differential; Disease Management; Hepatic Encephalopathy; Hepatitis, Viral, Human; Humans; Illicit Drugs; Liver Failure, Acute; Liver Function Tests; Liver Transplantation; Mushroom Poisoning; Neurologic Examination; Occupational Diseases; Respiratory Insufficiency; Sepsis; Shock; Time Factors; Valproic Acid | 2013 |
Toxin-induced hepatic injury.
Topics: Acetaminophen; Alcohols; Amanita; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mushroom Poisoning; Steroids; United States; Valproic Acid | 2014 |
Characterization of hepatocyte-based in vitro systems for reliable toxicity testing.
Topics: Acetaminophen; Animals; Cell Survival; Cells, Cultured; Hepatocytes; Humans; Liver; Toxicity Tests; Valproic Acid | 2018 |
37 other study(ies) available for valproic acid and acetaminophen
Article | Year |
---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
In vitro testing for developmental toxicity using the Hydra attenuata assay.
Topics: Acetaminophen; Animals; Dimethyl Sulfoxide; Ethanol; Hexachlorocyclohexane; Hydra; Isoniazid; Regeneration; Teratogens; Toxicology; Valproic Acid | 1985 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil | 1984 |
Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.
Topics: Acetaminophen; Adult; Drug Interactions; Epilepsy; Humans; Kinetics; Male; Valproic Acid | 1981 |
Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy.
Topics: Acetaminophen; Animals; Charcoal; Digoxin; Disease Models, Animal; Drug Administration Schedule; Female; Half-Life; Linear Models; Metabolic Clearance Rate; Pharmacokinetics; Poisoning; Poisons; Prospective Studies; Random Allocation; Swine; Theophylline; Valproic Acid | 1995 |
Assessing the mechanism of metabolism-dependent valproic acid-induced in vitro cytotoxicity.
Topics: Acetaminophen; Animals; Anticonvulsants; Antioxidants; Female; Glutathione; Humans; In Vitro Techniques; Iron Chelating Agents; Lymphocytes; Poly(ADP-ribose) Polymerase Inhibitors; Rabbits; Reactive Oxygen Species; Valproic Acid | 1999 |
The binding of acetaminophen, lidocaine, and valproic acid to human milk.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Local; Anticonvulsants; Female; Humans; Lidocaine; Milk, Human; Valproic Acid | 2004 |
Pharmaceutical drug overdose case reports. From the World Literature.
Topics: Acetaminophen; Adolescent; Adult; Aged; Amlodipine; Child, Preschool; Diphenhydramine; Dizocilpine Maleate; Drug Overdose; Female; Humans; International Normalized Ratio; Lithium; Male; Middle Aged; Paroxetine; Salicylates; Valproic Acid; Warfarin | 2003 |
Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; Developmental Disabilities; Drug Therapy, Combination; Enzymes; Female; Fructose; Humans; Infant; Influenza, Human; Liver Function Tests; Male; Myoclonic Epilepsy, Juvenile; NAV1.1 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Sodium Channels; Syndrome; Topiramate; Valproic Acid | 2008 |
The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study.
Topics: Acetaminophen; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Case-Control Studies; Databases, Factual; Drug Eruptions; Drug Interactions; Erythema Multiforme; Female; Humans; Male; Middle Aged; Stevens-Johnson Syndrome; Valproic Acid | 2008 |
Use of hemodialysis and hemoperfusion in poisoned patients.
Topics: Acetaminophen; Carbamazepine; Ethylene Glycol; Hemoperfusion; Humans; Lithium; Poisoning; Poisons; Renal Dialysis; Retrospective Studies; Sorption Detoxification; Valproic Acid | 2008 |
Acute renal failure following detergent ingestion.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Depression; Detergents; Eating; Female; Fluoxetine; Humans; Treatment Outcome; Valproic Acid | 2009 |
Evaluation of a screening method by liquid chromatography-tandem mass spectrometry for estimating effect of drugs on the activation and β-oxidation of fatty acids in mitochondria.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Coenzyme A Ligases; Diclofenac; Enzyme Inhibitors; Fatty Acids; Lipid Metabolism; Male; Mice; Mice, Mutant Strains; Mitochondria, Liver; Oxidation-Reduction; Salicylic Acid; Tandem Mass Spectrometry; Valproic Acid | 2010 |
Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Chlorocebus aethiops; Disease Models, Animal; Female; Glycine; Hyperglycinemia, Nonketotic; Male; Pilot Projects; Valproic Acid | 2012 |
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.
Topics: Acetaminophen; Adenosine Triphosphate; Amiodarone; Bioreactors; Diclofenac; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Lethal Dose 50; Metformin; Phenformin; Proteins; Reproducibility of Results; Risk Assessment; Spheroids, Cellular; Toxicity Tests; Valproic Acid | 2012 |
Comparative evaluation of cariogenic and erosive potential of commonly prescribed pediatric liquid medicaments: an in vitro study.
Topics: Acetaminophen; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antipyretics; Calcium; Cariogenic Agents; Dental Enamel; Dietary Supplements; Drug Combinations; Ferric Compounds; Humans; Hydrogen-Ion Concentration; Ibuprofen; Pharmaceutical Solutions; Solubility; Sucrose; Sweetening Agents; Tooth Erosion; Valproic Acid; Vitamins | 2014 |
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™.
Topics: Acetaminophen; Adverse Drug Reaction Reporting Systems; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Liver Injury; Data Mining; Databases, Factual; Drug Interactions; Isoniazid; Valproic Acid; World Health Organization | 2015 |
Serotonin syndrome in patients with headache disorders.
Topics: Acetaminophen; Adult; Amitriptyline; Analgesics; Cluster Headache; Drug Therapy, Combination; Flunarizine; Humans; Lithium; Male; Middle Aged; Migraine Disorders; Serotonin Agents; Serotonin Syndrome; Tramadol; Valproic Acid | 2017 |
Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals.
Topics: Acetaminophen; Animals; Computational Biology; Databases, Chemical; Endocrine Disruptors; Environmental Exposure; Environmental Pollutants; Humans; Models, Biological; Polychlorinated Dibenzodioxins; Risk Assessment; Toxicology; Valproic Acid | 2020 |
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Topics: Acetaminophen; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Citric Acid; Hep G2 Cells; Humans; Liver; Metabolic Networks and Pathways; Metabolome; Metabolomics; Quality Control; Reproducibility of Results; Valproic Acid; Xenobiotics | 2021 |
Phosphonate Derivatives of Paracetamol and Valproic Acid.
Topics: Acetaminophen; Animals; Mice; Organophosphonates; Phosphorous Acids; Valproic Acid | 2023 |