valproic acid has been researched along with 2-propyl-4-pentenoic acid in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (16.13) | 18.7374 |
| 1990's | 14 (45.16) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Brenstrum, T; Capretta, A; Kim, AJ; Ohnmacht, SA; Panna, E; Werstuck, GH | 1 |
| Baillie, TA | 1 |
| Nau, H; Wegner, C | 1 |
| Chen, JS; Shen, YZ; Yang, SC; Yu, HY | 1 |
| Elmazar, MM; Hauck, RS; Nau, H | 1 |
| Li, J; Mao, LF; Norwood, DL; Schulz, H | 1 |
| Acheampong, A; Anderson, GD; Baillie, TA; Friel, PN; Guyot, M; Levy, RH; Loiseau, P; Rettenmeier, AW; Tor, J; Wilensky, AJ | 1 |
| Hauck, RS; Nau, H | 1 |
| Baillie, TA; Howald, WN; Rettenmeier, AW; Rettie, AE | 1 |
| Arnetoli, G; Bendoni, L; Campostrini, R; Moroni, F; Paganini, M; Zaccara, G; Zappoli, R | 1 |
| Baillie, TA; Boberg, M; Rettenmeier, AW; Rettie, AE | 1 |
| Baillie, TA; Bjorge, SM | 1 |
| Baillie, TA; Gonzalez, FJ; Korzekwa, KR; Philpot, RM; Rettie, AE; Sheffels, PR | 1 |
| Baverel, G; Elhamri, M; Ferrier, B; Martin, M | 2 |
| Baillie, TA; Davis, MR; Grillo, MP; Hu, P; Jin, L; Kassahun, K | 1 |
| Abbott, FS; Tang, W | 2 |
| Gofflot, F; Picard, JJ; van Maele-Fabry, G | 1 |
| Fisher, MB; Gonzalez, FJ; Korzekwa, KR; Rettie, AE; Sadeque, AJ | 1 |
| de Almeida, IT; Duran, M; IJlst, L; Jakobs, C; Ruiter, JP; Silva, MF; Wanders, RJ | 1 |
| Bialer, M; Eyal, S; Shimshoni, J; Yagen, B | 1 |
| Blum, W; Byrd, JC; Chan, KK; Cheng, H; Grever, MR; Klisovic, R; Liu, Z; Marcucci, G | 1 |
| Baek, DJ; Chung, BC; Jung, BH; Kim, BJ; Lee, MS; Lee, YJ; Shin, KJ | 1 |
| Kondo, T; Mihara, K; Nagai, G; Nakamura, A; Ono, S; Yasui-Furukori, N | 1 |
| Jung, BH; Kim, BJ; Lee, JH; Lee, MS; Lee, YJ; Oh, JH | 1 |
| Chen, SD; Chen, ZJ; Fang, ZY; Huang, M; Li, JL; Shu, WY; Wang, HS; Wang, XD; Zhang, Y; Zhou, JQ; Zhou, LM | 1 |
| Bello, M; Correa-Basurto, J; Mendieta-Wejebe, JE | 1 |
| Chen, ZJ; Fang, ZY; Huang, HB; Huang, M; Li, JL; Wang, HS; Wang, XD; Zhou, JQ; Zhou, LM | 1 |
| Li, G; Qiu, F; Sun, Y; Zhang, T; Zhao, L; Zhao, M | 1 |
| Critchley, D; Gidal, B; Morrison, G; Patsalos, PN; Szaflarski, JP; VanLandingham, K | 1 |
2 review(s) available for valproic acid and 2-propyl-4-pentenoic acid
| Article | Year |
|---|---|
Metabolism of valproate to hepatotoxic intermediates.
Topics: Animals; Biotransformation; Coenzyme A; Cytochrome P-450 Enzyme System; Fatty Acids, Monounsaturated; Humans; Liver; Mitochondria, Liver; Rats; Valproic Acid | 1992 |
Clinical implications of trials investigating drug-drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs.
Topics: Anticonvulsants; Cannabidiol; Clinical Trials as Topic; Clobazam; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inducers; Cytochrome P-450 CYP2C19 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Dioxolanes; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Fatty Acids, Monounsaturated; Humans; Lennox Gastaut Syndrome; Valproic Acid | 2020 |
29 other study(ies) available for valproic acid and 2-propyl-4-pentenoic acid
| Article | Year |
|---|---|
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.
Topics: Anticonvulsants; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Molecular Structure; Valproic Acid | 2004 |
Alteration of embryonic folate metabolism by valproic acid during organogenesis: implications for mechanism of teratogenesis.
Topics: Animals; Circadian Rhythm; Fatty Acids, Monounsaturated; Female; Fetus; Folic Acid; Leucovorin; Mice; Neural Tube Defects; Pregnancy; Valproic Acid | 1992 |
Effects of sodium valproate and 4en-valproic acid on isolated hepatocytes of guinea pigs.
Topics: Animals; Cell Membrane Permeability; Cell Survival; Fatty Acids, Monounsaturated; Guinea Pigs; Liver; Male; Valproic Acid | 1991 |
On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic
Topics: Animals; Anticonvulsants; Drug Design; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Mice; Mice, Inbred Strains; Pentylenetetrazole; Pregnancy; Regression Analysis; Seizures; Stereoisomerism; Teratogens; Valproic Acid | 1991 |
Mitochondrial metabolism of valproic acid.
Topics: Acyl Coenzyme A; Animals; Cell Compartmentation; Chromatography, High Pressure Liquid; Fatty Acids, Monounsaturated; In Vitro Techniques; Intracellular Membranes; Mass Spectrometry; Microbodies; Mitochondria, Liver; Oxidation-Reduction; Rats; Valproic Acid | 1991 |
Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid.
Topics: Adult; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dioxolanes; Dioxoles; Drug Interactions; Enzyme Activation; Fatty Acids, Monounsaturated; Female; Humans; Liver; Male; Phenytoin; Valproic Acid | 1990 |
Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid.
Topics: Abnormalities, Drug-Induced; Animals; Fatty Acids, Monounsaturated; Female; Mice; Neural Tube Defects; Stereoisomerism; Valproic Acid | 1989 |
Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Microsomes, Liver; Mixed Function Oxygenases; Rats; Valproic Acid | 1987 |
Lack of relationship between sodium valproate-induced adverse effects and the plasma concentration of its metabolite 2-propylpenten-4-oic acid.
Topics: Adolescent; Adult; Ammonia; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Female; Humans; Kinetics; Male; Valproic Acid | 1987 |
Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.
Topics: Animals; Carbamazepine; Cytochrome P-450 Enzyme System; Deuterium; Enzyme Induction; Fatty Acids, Monounsaturated; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydroxylation; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Phenobarbital; Phenytoin; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Valproic Acid | 1988 |
Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid.
Topics: Adenosine Triphosphate; Animals; Caproates; Caprylates; Coenzyme A; Decanoic Acids; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Liver; Rats; Valproic Acid | 1985 |
CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid.
Topics: Animals; Cytochrome P-450 Enzyme System; Deuterium; Fatty Acids, Monounsaturated; Female; Hydroxylation; Isoenzymes; Lung; Male; Microsomes; Oxidoreductases; Rabbits; Substrate Specificity; Valproic Acid | 1995 |
Effect of valproate and of two of its metabolites on renal substrate uptake and ammoniagenesis in the rat in vivo.
Topics: Ammonia; Animals; Fatty Acids, Monounsaturated; Kidney; Male; Rats; Valproic Acid | 1994 |
Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
Topics: Acetylcysteine; Animals; Biotransformation; Chromatography, Liquid; Coenzyme A; Fatty Acids, Monounsaturated; Glutathione; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Triglycerides; Valproic Acid | 1994 |
Effect of valproate, sodium 2-propyl-4-pentenoate and sodium 2-propyl-2-pentenoate on renal substrate uptake and ammoniagenesis in the rat.
Topics: Ammonia; Animals; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Glomerular Filtration Rate; Ketone Bodies; Kidney; Male; Rats; Rats, Wistar; Renal Circulation; Stimulation, Chemical; Urodynamics; Valproic Acid | 1993 |
Characterization of thiol-conjugated metabolites of 2-propylpent-4-enoic acid (4-ene VPA), a toxic metabolite of valproic acid, by electrospray tandem mass spectrometry.
Topics: Animals; Anticonvulsants; Bile; Biotransformation; Chromatography, Liquid; Fatty Acids, Monounsaturated; Liver; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Online Systems; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Valproic Acid | 1996 |
Cranial nerves and ganglia are altered after in vitro treatment of mouse embryos with valproic acid (VPA) and 4-en-VPA.
Topics: Animals; Brain Stem; Cranial Nerves; Embryo, Mammalian; Face; Facial Nerve; Fatty Acids, Monounsaturated; Female; GABA Agents; Glossopharyngeal Nerve; Immunoenzyme Techniques; Male; Mice; Mice, Inbred Strains; Organ Culture Techniques; Peripheral Nerves; Teratogens; Trigeminal Nerve; Vagus Nerve; Valproic Acid; Vestibulocochlear Nerve | 1996 |
A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics.
Topics: Animals; Area Under Curve; Biotransformation; Fatty Acids, Monounsaturated; Half-Life; Liver; Male; Metabolic Clearance Rate; Protein Binding; Rats; Rats, Sprague-Dawley; Valproic Acid | 1997 |
Human CYP2C9 and CYP2A6 mediate formation of the hepatotoxin 4-ene-valproic acid.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Child; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; Fatty Acids, Monounsaturated; Female; Humans; Liver; Male; Middle Aged; Mixed Function Oxygenases; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Valproic Acid | 1997 |
Differential effect of valproate and its Delta2- and Delta4-unsaturated metabolites, on the beta-oxidation rate of long-chain and medium-chain fatty acids.
Topics: Animals; Anticonvulsants; Cell Survival; Fatty Acids, Monounsaturated; Hepatocytes; Male; Myristic Acid; Oleic Acid; Oxidation-Reduction; Palmitic Acid; Phenylpropionates; Rats; Rats, Wistar; Tritium; Valproic Acid | 2001 |
Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Histone Deacetylase Inhibitors; Humans; Pentanoic Acids; Structure-Activity Relationship; Valproic Acid | 2005 |
Quantification of valproic acid and its metabolite 2-propyl-4-pentenoic acid in human plasma using HPLC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Fatty Acids, Monounsaturated; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Valproic Acid | 2007 |
The relationship between glucuronide conjugate levels and hepatotoxicity after oral administration of valproic acid.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anticonvulsants; Aspartate Aminotransferases; Biotransformation; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Isoenzymes; Liver; Liver Diseases; Male; Rats; Rats, Sprague-Dawley; Valproic Acid | 2009 |
Formulations of valproate alter valproate metabolism: a single oral dose kinetic study.
Topics: Administration, Oral; Adult; Chemistry, Pharmaceutical; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Male; Microsomes; Oxidation-Reduction; Structure-Activity Relationship; Valproic Acid | 2009 |
Dose-dependent pharmacokinetics of toxic metabolites is not related to increased toxicity following high-dose valproic acid in rats.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Gas Chromatography-Mass Spectrometry; Humans; Liver; Male; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Valproic Acid | 2010 |
Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; China; Chromatography, High Pressure Liquid; Epilepsy; Fatty Acids, Monounsaturated; Female; Humans; Iran; Male; United States; Valproic Acid; Young Adult | 2012 |
Structural and energetic analysis to provide insight residues of CYP2C9, 2C11 and 2E1 involved in valproic acid dehydrogenation selectivity.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Catalytic Domain; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2E1; Cytochrome P450 Family 2; Databases, Protein; Fatty Acids, Monounsaturated; Humans; Hydrogen; Kinetics; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Binding; Rats; Sequence Alignment; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Structural Homology, Protein; Substrate Specificity; Thermodynamics; Valproic Acid | 2014 |
[Effects of carbamazepine on plasma concentrations of valproic acid and its toxic metabolite in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Fatty Acids, Monounsaturated; Female; Humans; Male; Valproic Acid; Young Adult | 2014 |
Associations of CYP2C9 and CYP2A6 Polymorphisms with the Concentrations of Valproate and its Hepatotoxin Metabolites and Valproate-Induced Hepatotoxicity.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Biotransformation; Chemical and Drug Induced Liver Injury; Child; China; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C9; Epilepsy; Fatty Acids, Monounsaturated; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Hospitals, University; Humans; Liver; Polymorphism, Single Nucleotide; Valproic Acid; Young Adult | 2017 |