valnoctamide has been researched along with valproic acid in 25 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 14 (56.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B | 1 |
| Barzaghi, N; Bialer, M; Haj-Yehia, A; Perucca, E; Pisani, F | 1 |
| Bialer, M; Haj-Yehia, A | 1 |
| Bergman, F; Bialer, M; Blotnik, S | 1 |
| Bialer, M; Ehlers, K; Nau, H; Radatz, M; Yagen, B | 1 |
| Bialer, M | 1 |
| Bialer, M; Haj-Yehia, A; Hurst, SI; Kroetz, DL; Levi, M; Levy, RH; Spiegelstein, O; Yagen, B | 1 |
| Bialer, M; Ebinger, G; Khan, GM; Lindekens, H; Michotte, Y; Smolders, I | 1 |
| Aoki, Y; Bialer, M; Fujiwara, M; Kurihara, H; Okada, A | 1 |
| Aoki, Y; Bialer, M; Fujiwara, M; Kurihara, H; Kushima, K; Okada, A | 1 |
| Aoki, Y; Bialer, M; Fujiwara, M; Kushima, K; Okada, A | 1 |
| Agam, G; Applebaum, J; Belmaker, RH; Bersudsky, Y; Gaiduk, Y; Mishory, A; Podberezsky, A; Sharony, L | 1 |
| Alex, AB; Bialer, M; Hen, N; Kaufmann, D; McDonough, JH; Pollock, A; Shekh-Ahmad, T; Stables, JP; White, HS; Wilcox, KS; Yagen, B | 1 |
| Bialer, M; Dudek, FE; Hen, N; Kaufmann, D; Nelson, C; Pouliot, W; Ricks, K; Roach, B; Shekh-Ahmad, T; Yagen, B | 1 |
| Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B | 1 |
| Bialer, M; Nanau, RM; Neuman, MG; Shekh-Ahmad, T; Yagen, B | 1 |
| Bialer, M; Hen, N; McDonough, JH; Shekh-Ahmad, T; Yagen, B | 1 |
| Bialer, M; Finnell, RH; Hen, N; McDonough, JH; Shekh-Ahmad, T; Wlodarczyk, BJ; Yagen, B | 1 |
| Basselin, M; Modi, HR; Rapoport, SI | 1 |
| Bialer, M; Finnell, RH; Mawasi, H; Shekh-Ahmad, T; Wlodarczyk, BJ | 1 |
| Bialer, M; Mawasi, H; McDonough, JH; Shekh-Ahmad, T; Yagen, B | 1 |
| Davis, JN; Gorres, KL; Miller, G; Ornaghi, S; Paidas, MJ; van den Pol, AN | 1 |
| Bialer, M; Eisenkraft, A; Elger, CE; Kudin, AP; Kunz, WS; Mawasi, H | 1 |
| Bialer, M; Cabrera, RM; Finnell, RH; Lin, YL; Wlodarczyk, BJ | 1 |
| Bello-Morales, R; de Castro, F; López-Guerrero, JA; Praena, B | 1 |
1 review(s) available for valnoctamide and valproic acid
| Article | Year |
|---|---|
The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus.
Topics: Amides; Animals; Anticonvulsants; Humans; Status Epilepticus; Stereoisomerism; Valproic Acid | 2015 |
1 trial(s) available for valnoctamide and valproic acid
| Article | Year |
|---|---|
Valnoctamide as a valproate substitute with low teratogenic potential in mania: a double-blind, controlled, add-on clinical trial.
Topics: Adult; Amides; Animals; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Mice; Middle Aged; Placebos; Pregnancy; Psychiatric Status Rating Scales; Risperidone; Teratogens; Treatment Outcome; Valproic Acid | 2010 |
23 other study(ies) available for valnoctamide and valproic acid
| Article | Year |
|---|---|
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Spinal Nerves; Urea; Valproic Acid | 2009 |
Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects.
Topics: Adult; Amides; Half-Life; Humans; Isomerism; Male; Valproic Acid | 1990 |
Pharmacokinetics of a valpromide isomer, valnoctamide, in dogs.
Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Dogs; Female; Half-Life; Injections, Intravenous; Male; Protein Binding; Valproic Acid | 1988 |
Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of rats.
Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Liver; Male; Rats; Tissue Distribution; Valproic Acid | 1996 |
Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Body Weight; Embryo, Mammalian; Female; Fetal Death; Mice; Mice, Inbred Strains; Pentanoic Acids; Pregnancy; Teratogens; Valproic Acid | 1998 |
Pharmacokinetic considerations in the design of better and safer new antiepileptic drugs.
Topics: Amides; Animals; Anticonvulsants; Biotransformation; Cyclopropanes; Dogs; Drug Design; Glycine; Mice; Rats; Rats, Sprague-Dawley; Valproic Acid | 1999 |
Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid.
Topics: Amides; Anti-Anxiety Agents; Anticonvulsants; Epoxide Hydrolases; Ethylene Glycols; Humans; Isomerism; Liver; Microsomes; Structure-Activity Relationship; Valproic Acid | 2000 |
In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
Topics: Amides; Animals; Anti-Anxiety Agents; Anticonvulsants; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; Valproic Acid | 2000 |
Amidic modification of valproic acid reduces skeletal teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Bone and Bones; Cartilage; Cesarean Section; Female; Fetus; Male; Mice; Molecular Structure; Neural Tube Defects; Valproic Acid | 2004 |
Polycomb homologs are involved in teratogenicity of valproic acid in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Bone and Bones; DNA-Binding Proteins; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Gene Silencing; Histone-Lysine N-Methyltransferase; Injections, Subcutaneous; Male; Mice; Myeloid-Lymphoid Leukemia Protein; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Pregnancy; Proto-Oncogenes; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Valproic Acid; Zinc Fingers | 2004 |
Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Embryo, Mammalian; Female; Gene Expression; Gene Expression Profiling; Immediate-Early Proteins; Mice; Neural Tube Defects; Oligonucleotide Array Sequence Analysis; Pregnancy; Valproic Acid | 2005 |
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hippocampus; Male; Mice; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Time Factors; Treatment Outcome; Valproic Acid | 2012 |
A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus.
Topics: Amides; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Male; Pentobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Valproic Acid | 2013 |
Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.
Topics: Aging; Allylisopropylacetamide; Amides; Animals; Anticonvulsants; Convulsants; Epilepsy, Generalized; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Stereoisomerism; Valproic Acid | 2013 |
Valproic acid derivatives signal for apoptosis and repair in vitro.
Topics: Amides; Apoptosis; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA Repair; Drug Hypersensitivity Syndrome; Gene Expression; Hepatocytes; Humans; Inflammation; Interferon-gamma; Interleukin-1; Interleukin-6; Keratin-18; Lymphocytes; Signal Transduction; Tumor Necrosis Factor-alpha; Valproic Acid | 2013 |
Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus.
Topics: Acute Disease; Amides; Animals; Anticonvulsants; Disease Models, Animal; Guinea Pigs; Humans; Rats; Seizures; Status Epilepticus; Treatment Outcome; Valproic Acid | 2013 |
Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential.
Topics: Amides; Animals; Anticonvulsants; Central Nervous System Stimulants; Male; Mice; Neural Tube Defects; Random Allocation; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stereoisomerism; Teratogens; Valproic Acid | 2014 |
Valnoctamide, a non-teratogenic amide derivative of valproic acid, inhibits arachidonic acid activation in vitro by recombinant acyl-CoA synthetase-4.
Topics: Amides; Arachidonic Acid; Coenzyme A Ligases; Dose-Response Relationship, Drug; Enzyme Activation; In Vitro Techniques; Iodine Isotopes; Models, Statistical; Valproic Acid | 2014 |
Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide--Amide derivatives of valproic acid.
Topics: Amides; Animals; Anticonvulsants; Female; Isomerism; Male; Mice; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Seizures; Valproic Acid | 2015 |
Mood stabilizers inhibit cytomegalovirus infection.
Topics: Amides; Animals; Cell Line; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Disease Models, Animal; Female; Humans; Male; Mice; Muromegalovirus; Tranquilizing Agents; Valproic Acid; Viral Load; Virus Replication | 2016 |
Mitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase.
Topics: Amides; Animals; Dihydrolipoamide Dehydrogenase; Liver; Mitochondria; Mitochondria, Liver; Pyruvic Acid; Rats; Valproic Acid | 2017 |
Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Female; Fetal Death; Fetus; Mice; Neural Tube Defects; Pregnancy; Teratogenesis; Teratogens; Teratoma; Valproic Acid | 2019 |
Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes.
Topics: Amides; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Herpesvirus 1, Human; Humans; Molecular Structure; Oligodendroglia; Rats; Valproic Acid; Viral Proteins; Virus Internalization; Virus Replication | 2019 |