Page last updated: 2024-09-05

valiolamine and inositol

valiolamine has been researched along with inositol in 13 studies

*Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction. [MeSH]

*Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction. [MeSH]

Compound Research Comparison

Studies
(valiolamine)
Trials
(valiolamine)
Recent Studies (post-2010)
(valiolamine)
Studies
(inositol)
Trials
(inositol)
Recent Studies (post-2010) (inositol)
16048,2684002,050

Protein Interaction Comparison

ProteinTaxonomyvaliolamine (IC50)inositol (IC50)
Chain B, Pulmonary surfactant-associated protein DHomo sapiens (human)5700
Chain A, Pulmonary surfactant-associated protein DHomo sapiens (human)5700
Sodium/myo-inositol cotransporter 2Homo sapiens (human)104

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19903 (23.08)18.7374
1990's2 (15.38)18.2507
2000's4 (30.77)29.6817
2010's3 (23.08)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Kamata, K; Kameda, Y; Matsui, K; Takeuchi, M; Yoshida, M1
Asano, N; Kameda, Y; Matsui, K; Takai, N; Takeuchi, M1
Asano, N; Fukase, H; Horii, S; Kameda, Y; Matsui, K; Matsuo, T1
Asano, N; Fukase, H; Horii, S; Kameda, Y; Matsui, K; Takeuchi, M; Yamaguchi, T1
Asano, N; Fukase, H; Horii, S; Kameda, Y; Matsui, K; Takeuchi, M; Yamaguchi, T; Yoshikawa, M1
Chen, X; Shen, Y; Zheng, Y1
Kanto, M; Ogawa, S1
Cheng, HM; Shing, TK1
Chang, YK; Chung, IY; Hong, SK; Kim, CJ; Kim, SB; Lee, JR; Li, H; Moon, MH; Nguyen, do QA; Seo, YG1
Hu, X; Qu, Q; Sun, Y; Wang, C; Wang, G; Wang, Y; Wen, Q; Yang, G1
Bin, BH; Cho, EG; Choi, H; Kim, KH; Lee, E; Lee, TR; Seo, J; Yang, SH1
Bin, BH; Cho, EG; Joo, YH; Lee, AY; Lee, TR; Shin, SS1
Aakula, B; Hill, ML; Karade, SS; Kiappes, JL; Manne, R; Mariuzza, RA; Treston, AM; Warfield, KL; Zitzmann, N1

Reviews

2 review(s) available for valiolamine and inositol

ArticleYear
Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors.
    Current medicinal chemistry, 2006, Volume: 13, Issue:1

    Topics: Biochemistry; Carbohydrate Sequence; Cyclohexanols; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Inositol; Molecular Sequence Data

2006
Synthesis of valiolamine and some precursors for bioactive carbaglycosylamines from (-)-vibo-quercitol produced by biogenesis of myo-inositol.
    Journal of natural products, 2007, Volume: 70, Issue:3

    Topics: Enzyme Inhibitors; Glycoside Hydrolases; Inositol; Molecular Structure

2007

Other Studies

11 other study(ies) available for valiolamine and inositol

ArticleYear
Inhibitory effect of pseudo-aminosugars on oligosaccharide glucosidases I and II and on lysosomal alpha-glucosidase from rat liver.
    Journal of biochemistry, 1990, Volume: 108, Issue:1

    Topics: alpha-Glucosidases; Amino Sugars; Animals; Chromatography, Gel; Cyclohexenes; Glucosidases; Glycoside Hydrolase Inhibitors; Hexosamines; In Vitro Techniques; Inositol; Kinetics; Liver; Lysosomes; Male; Rats; Rats, Inbred Strains; Streptomyces

1990
Inhibitory effect of validamine, valienamine and valiolamine on activities of carbohydrases in rat small intestinal brush border membranes.
    Chemical & pharmaceutical bulletin, 1990, Volume: 38, Issue:7

    Topics: Animals; Cyclohexenes; Glycoside Hydrolases; Hexosamines; In Vitro Techniques; Inositol; Intestine, Small; Male; Microvilli; Rats; Rats, Inbred Strains

1990
Synthesis and alpha-D-glucosidase inhibitory activity of N-substituted valiolamine derivatives as potential oral antidiabetic agents.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:6

    Topics: Animals; Cyclohexanols; Glucosidases; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Inositol; Stereoisomerism; Structure-Activity Relationship; Swine

1986
Epivaliolamine and deoxyvalidamine, new pseudo-aminosugars produced by Streptomyces hygroscopicus.
    The Journal of antibiotics, 1985, Volume: 38, Issue:12

    Topics: Chemical Phenomena; Chemistry; Glucosidases; Glycoside Hydrolase Inhibitors; Inositol; Streptomyces

1985
Valiolamine, a new alpha-glucosidase inhibiting aminocyclitol produced by Streptomyces hygroscopicus.
    The Journal of antibiotics, 1984, Volume: 37, Issue:11

    Topics: Chemical Phenomena; Chemistry; Glucosidases; Glycoside Hydrolase Inhibitors; Inositol; Streptomyces

1984
Intramolecular direct aldol reactions of sugar diketones: syntheses of valiolamine and validoxylamine G.
    Organic letters, 2008, Sep-18, Volume: 10, Issue:18

    Topics: Aldehydes; Carbohydrates; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Inositol; Ketones

2008
Quantitative analysis of valiolamine through pre-column derivatization with phenylisocyanate using high-performance liquid chromatography with UV detection: selection of reagent, identification of derivative and optimization of derivatization conditions.
    Journal of pharmaceutical and biomedical analysis, 2009, May-01, Volume: 49, Issue:4

    Topics: Analysis of Variance; Anti-Bacterial Agents; Bacteria; Biological Assay; Calibration; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Indicators and Reagents; Inositol; Isocyanates; Reference Standards; Reproducibility of Results; Solvents; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Temperature

2009
Novel reagents for quantitative analysis of valiolamine in biological samples by high-performance liquid chromatography with pre-column UV derivatization.
    Talanta, 2010, Jun-15, Volume: 81, Issue:4-5

    Topics: Biotechnology; Calibration; Chemistry Techniques, Analytical; Chromatography; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Inositol; Models, Chemical; Nitrobenzenes; Pharmaceutical Preparations; Quality Control; Temperature; Time Factors; Ultraviolet Rays

2010
Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis.
    Experimental dermatology, 2013, Volume: 22, Issue:8

    Topics: Acarbose; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Inflammation; Inositol; Mannosidases; Melanins; Melanocytes; Microscopy, Electron, Transmission; Monophenol Monooxygenase; Permeability; Polysaccharides; Real-Time Polymerase Chain Reaction; Skin

2013
Novel inhibitory effect of N-(2-hydroxycyclohexyl)valiolamine on melanin production in a human skin model.
    International journal of molecular sciences, 2014, Jul-09, Volume: 15, Issue:7

    Topics: Cells, Cultured; Cyclohexanols; Humans; Inositol; Melanins; Melanocytes; Monophenol Monooxygenase

2014
N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity.
    Journal of medicinal chemistry, 2021, 12-23, Volume: 64, Issue:24

    Topics: alpha-Glucosidases; Animals; Antiviral Agents; Binding Sites; Chlorocebus aethiops; Crystallography, X-Ray; Dengue Virus; Endoplasmic Reticulum; Glycoside Hydrolase Inhibitors; Humans; Imino Sugars; Inositol; Mice; Microbial Sensitivity Tests; Molecular Docking Simulation; Protein Binding; SARS-CoV-2; Vero Cells

2021