valinomycin and savinin

valinomycin has been researched along with savinin* in 1 studies

Other Studies

1 other study(ies) available for valinomycin and savinin

Article	Year
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17 In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects. Topics: Animals; Betulinic Acid; Cell Proliferation; Chlorocebus aethiops; Coronavirus 3C Proteases; Cysteine Endopeptidases; Lignans; Models, Molecular; Pentacyclic Triterpenes; Plants, Medicinal; Severe acute respiratory syndrome-related coronavirus; Structure-Activity Relationship; Terpenes; Triterpenes; Vero Cells; Viral Proteins; Virus Replication	2007

Article

Year

Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

Journal of medicinal chemistry, 2007, Aug-23, Volume: 50, Issue:17

In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.

Topics: Animals; Betulinic Acid; Cell Proliferation; Chlorocebus aethiops; Coronavirus 3C Proteases; Cysteine Endopeptidases; Lignans; Models, Molecular; Pentacyclic Triterpenes; Plants, Medicinal; Severe acute respiratory syndrome-related coronavirus; Structure-Activity Relationship; Terpenes; Triterpenes; Vero Cells; Viral Proteins; Virus Replication

2007