valine has been researched along with thiazoles in 109 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (6.42) | 18.7374 |
| 1990's | 70 (64.22) | 18.2507 |
| 2000's | 14 (12.84) | 29.6817 |
| 2010's | 16 (14.68) | 24.3611 |
| 2020's | 2 (1.83) | 2.80 |
| Authors | Studies |
|---|---|
| Deutsch, HF; Fett, JW | 1 |
| Austin, P; Collier, PJ; Gilbert, P; Ramsey, AJ | 1 |
| Jian, DL; Jian, ZG; Long, KH | 1 |
| Iwashima, A; Kawasaki, T; Nakamura, M; Nose, Y | 1 |
| Nakamura, M; Nakata, T; Nose, Y | 1 |
| Feingold, DS; Vance, DE | 1 |
| Ebata, M; Miyazaki, K; Otsuka, H | 1 |
| Gozlan, M | 1 |
| Bouza, E; Carr, A; Danner, SA; Gonzales, J; Gudiol, F; Lehman, LM; Leonard, JM; Pintado, V; Raventos, A; Rubio, R | 1 |
| Henry, D; Hsu, A; Hurley, AM; La Marca, A; Leonard, JM; Markowitz, M; Powderly, WG; Saag, M; Sattler, F; Valdes, JM | 1 |
| Steele, F | 1 |
| Anderson, B; Erickson, JW; Gulnik, SV; Liu, B; Mitsuya, H; Suvorov, LI; Yu, B | 1 |
| Denissen, JF; Fino, L; Flentge, CA; Green, BE; Kempf, DJ; Kong, XP; Marsh, KC; McDonald, E; Park, CH; Vasavanonda, S | 1 |
| Bhat, TN; Erickson, JW; Ho, DD; Kempf, DJ; Markowitz, M; Mo, H; Norbeck, DW | 1 |
| Carr, A; Cooper, DA; Kelleher, AD; Zaunders, J | 1 |
| Fantucci, P; Marino, T; Russo, N; Villa, AM | 1 |
| Barnett, AA | 1 |
| Tastemain, C | 1 |
| Cimons, M | 1 |
| Nelson, H | 1 |
| Ho, DD; Leonard, JM; Markowitz, M; Neumann, AU; Perelson, AS | 1 |
| Buko, AM; Denissen, JF; Kumar, GN; Rodrigues, AD | 1 |
| Cohen, J | 2 |
| Nathan, R | 1 |
| Boucher, CA; Chernyavskiy, T; Gao, Q; Granneman, GR; Ho, DD; Hsu, A; Kempf, DJ; Korneyeva, M; Leonard, JM; Lyons, N; Markowitz, M; Mo, HM; Molla, A; Niu, P; Norbeck, DW; Schipper, PJ; Vasavanonda, S | 1 |
| Blum, MR; Millard, J; Painter, G; Parry, N; Rooney, J; Sadler, BM; St Clair, MH; Tisdale, M | 1 |
| Biron, F; Boibieux, A; Duong, M; Grappin, M; Sgro, C | 1 |
| Leonard, JM | 1 |
| Schenk, M | 1 |
| Phillips, L | 1 |
| Vella, S | 1 |
| Baker, R | 3 |
| Barr, D; Gilden, D | 1 |
| Chang, HE | 1 |
| Smart, T | 2 |
| James, JS | 4 |
| Alcorn, K | 1 |
| Gilden, D; Smart, T | 1 |
| Cheng, B | 1 |
| MacDougall, DS | 1 |
| Schouten, JT | 1 |
| Folkers, G | 1 |
| Mascolini, M | 1 |
| Du, HN; Hu, HY; Hu, J; Li, HT; Luo, XY; Tang, L; Zhou, JW | 1 |
| DILLEY, J; DOULL, J | 1 |
| Phillips, AJ; Sammakia, T; Zhang, Y | 1 |
| Avery, MA; Benson, SC; Chittiboyina, A; Desai, P; Ho, CI; Kurtz, TW; Pershadsingh, HA; Pravenec, M; Qi, N; Wang, J | 1 |
| Imagawa, Y; Kimura, S; Satake, K; Tsukuda, M | 1 |
| Cumin, F; Menard, J; Schnell, CR; Webb, RL; Wood, JM | 1 |
| Kim, HJ; Kim, J; Kim, KS; Kim, M; Kim, SH; Koh, SH; Lee, KW; Lee, YB; Lee, YJ | 1 |
| Keasling, JD; Muller, SJ; Wang, K | 1 |
| Jones, EM; Surewicz, K; Surewicz, WK | 1 |
| Caughey, B; James, W; Sim, VL; Tahiri-Alaoui, A | 1 |
| Bertram, A; Maulucci, N; Mohd Nor, SM; New, OM; Pattenden, G | 1 |
| Branford, S; Hughes, TP; Nicoll, JM; Paquette, RL; Sawyers, CL; Shah, NP; Skaggs, BJ | 1 |
| Liang, G; Wei, H; Yang, H | 1 |
| Barak, Z; Binshtein, E; Chipman, DM; Kaplun, A; Shaanan, B; Steinmetz, A; Tittmann, K; Vyazmensky, M | 1 |
| Chang, ES; Chen, RP; Fann, W; Liao, TY; Lim, TS | 1 |
| Dzhala, V; Glykys, J; Khazipov, R; Staley, K; Valeeva, G | 1 |
| Ciaccio, NA; Laurence, JS; Middaugh, CR; Reynolds, TS | 1 |
| Cortez, LM; Kumar, J; Renault, L; Sim, VL; Young, HS | 1 |
| Beran, RK; Bush, CO; Delaney, WE; Greenstein, AE | 1 |
| Ames, D; Bourgeat, P; Bush, AI; Darby, D; Ellis, KA; Harrington, KD; Laws, SM; Lim, YY; Martins, RN; Maruff, P; Masters, CL; Nathan, PJ; Pietrzak, RH; Rowe, CC; Salvado, O; Snyder, PJ; Villemagne, VL | 1 |
| Ambudkar, SV; Chufan, EE; Kapoor, K; Patel, BA; Prasad, NR; Singh, S; Talele, TT | 1 |
| Dieterich, DT; Martel-Laferrière, V | 1 |
| Asselah, T; Halfon, P; Marcellin, P; Schinazi, R | 1 |
| Ford, N; Fortunak, J; Hill, A; Khoo, S; Simmons, B | 1 |
| Ambudkar, SV; Chen, ZS; Chufan, EE; Patel, BA; Prasad, NR; Singh, S; Talele, TT; Wang, YJ | 1 |
| Hodges, MR; Ottosen, S; Parsley, TB; Patick, AK; Raney, AK; van der Veer, E; van Doorn, LJ; Yang, L; Zeh, K | 1 |
| Camerlingo, R; Ceccarelli, LS; Costantino, V; Della Sala, G; Esposito, G; Irollo, E; Mangoni, A; Miceli, R; Pirozzi, G; Teta, R | 1 |
| Birkmann, A; Corey, L; Fife, K; Huang, ML; Johnston, C; Magaret, A; Ruebsamen-Schaeff, H; Selke, S; Stobernack, HP; Timmler, B; Tyring, S; Wald, A; Warren, T; Zimmermann, H | 1 |
| Alqahtani, S; Ambudkar, SV; Anreddy, N; Chen, ZS; Kaddoumi, A; Patel, BA; Shukla, S; Singh, S; Talele, TT; Wang, YJ; Zhang, GN; Zhang, YK | 1 |
| Chen, S; Chen, Y; Ma, X; Xu, Z; Ye, T | 1 |
| Borduas-Dedekind, N; Lau, K; Manfrin, A; McNeill, K | 1 |
| Tsanni, A | 1 |
| Akpomiemie, G; Bosch, B; Casas, CP; Ellis, L; Hill, A; Johnstone, H; Owen, A; Simmons, B; Sokhela, S; Venter, WDF; Woods, J | 1 |
3 review(s) available for valine and thiazoles
| Article | Year |
|---|---|
Perspectives in HIV protease inhibitors.
Topics: Antiviral Agents; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Ritonavir; Thiazoles; Valine | 1996 |
Treating HCV in HIV 2013: on the cusp of change.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Coinfection; Drug Interactions; Drug Therapy, Combination; Hepacivirus; Hepatitis C; HIV Infections; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Sofosbuvir; Thiazoles; Treatment Outcome; Uridine Monophosphate; Valine | 2014 |
HCV direct-acting antiviral agents: the best interferon-free combinations.
Topics: Aminoisobutyric Acids; Antiviral Agents; Carbamates; Clinical Trials as Topic; Disease Eradication; Drug Discovery; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Interferon-alpha; Isoquinolines; Leucine; Oligopeptides; Polyethylene Glycols; Proline; Protease Inhibitors; Pyrrolidines; Quinolines; Recombinant Proteins; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine; Viral Nonstructural Proteins; Virus Replication | 2014 |
13 trial(s) available for valine and thiazoles
| Article | Year |
|---|---|
A short-term study of the safety, pharmacokinetics, and efficacy of ritonavir, an inhibitor of HIV-1 protease. European-Australian Collaborative Ritonavir Study Group.
Topics: Adult; Antiviral Agents; CD4 Lymphocyte Count; Double-Blind Method; Female; HIV Core Protein p24; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Ritonavir; RNA, Viral; Thiazoles; Treatment Outcome; Valine | 1995 |
A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection.
Topics: Adult; Antiviral Agents; CD4 Lymphocyte Count; Double-Blind Method; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Ritonavir; RNA, Viral; Thiazoles; Treatment Outcome; Valine | 1995 |
Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, Differentiation; Antiviral Agents; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Double-Blind Method; HIV Infections; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Immune System; Leukocyte Common Antigens; Lymphocyte Activation; Membrane Glycoproteins; N-Glycosyl Hydrolases; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Ritonavir; RNA, Viral; Thiazoles; Valine; Viremia | 1996 |
In vitro antiviral activity of 141W94 (VX-478) in combination with other antiretroviral agents.
Topics: Carbamates; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Pyridines; Quinolines; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Sulfonamides; Thiazoles; Valine | 1996 |
Treatment for primary infection.
Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Cohort Studies; Controlled Clinical Trials as Topic; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Placebos; Pyridines; Ritonavir; Thiazoles; Valine; Zalcitabine; Zidovudine | 1995 |
Lottery opens for Abbott protease drug.
Topics: Acquired Immunodeficiency Syndrome; CD4 Lymphocyte Count; HIV Protease Inhibitors; Humans; Patient Selection; Ritonavir; Thiazoles; Valine | 1995 |
Ritonavir (Abbott protease inhibitor) proves survival benefit in late-stage AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; CD4 Lymphocyte Count; Double-Blind Method; HIV Protease Inhibitors; Humans; Ritonavir; Survivors; Thiazoles; Valine | 1996 |
Abbott laboratories files New Drug Application for ritonavir.
Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Double-Blind Method; Drugs, Investigational; HIV Infections; HIV Protease Inhibitors; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Ritonavir; Thiazoles; Valine; Zalcitabine; Zidovudine | 1996 |
Protease inhibitors: ritonavir and saquinavir combination trial recruiting--seven U.S., Canada sites incl. San Francisco.
Topics: Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
Matching up ritonavir with saquinavir.
Topics: Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122.
Topics: 5' Untranslated Regions; Antiviral Agents; Carbamates; Cyclohexanols; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Macrocyclic Compounds; MicroRNAs; Molecular Targeted Therapy; Mutation; Oligonucleotides; Oligopeptides; Pyrrolidines; Quinolines; Replicon; Thiazoles; Thiophenes; Valine | 2015 |
Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
Topics: Acyclovir; Adult; Aged; Antiviral Agents; Cross-Over Studies; Double-Blind Method; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Male; Middle Aged; Pyridines; Recurrence; Sulfonamides; Thiazoles; Valacyclovir; Valine; Virus Shedding; Young Adult | 2016 |
Randomized clinical trial of nitazoxanide or sofosbuvir/daclatasvir for the prevention of SARS-CoV-2 infection.
Topics: Antiviral Agents; Carbamates; COVID-19; Humans; Imidazoles; Nitro Compounds; Pyrrolidines; SARS-CoV-2; Sofosbuvir; South Africa; Thiazoles; Treatment Outcome; Valine | 2022 |
93 other study(ies) available for valine and thiazoles
| Article | Year |
|---|---|
The variability of human lambda-chain constant regions and some relationships to V-regions sequences.
Topics: Alanine; Amino Acid Sequence; Chromatography, Gel; Chromatography, Ion Exchange; Cystine; Electrophoresis, Paper; Glutamates; Glycine; Humans; Immunoglobulin lambda-Chains; Immunoglobulin Light Chains; Isoleucine; Leucine; Peptides; Proline; Serine; Thiazoles; Threonine; Valine | 1976 |
Growth inhibitory and biocidal activity of some isothiazolone biocides.
Topics: Disinfectants; DNA Replication; Escherichia coli; Fungicides, Industrial; Glutathione; Histidine; Microbial Sensitivity Tests; Schizosaccharomyces; Thiazoles; Valine | 1990 |
[Synthesis of the marine cyclopeptide thiazole amino acid component (D-Val)Thz].
Topics: Chemical Phenomena; Chemistry; Thiazoles; Valine | 1988 |
Effect of amino acids and purine bases on thiamine synthesis by Escherichia coli.
Topics: Adenine; Amino Acids; Aspartic Acid; Culture Media; Cystine; Cytosine; Escherichia coli; Glutamates; Glycine; Guanine; Histidine; Hypoxanthines; Inositol; Isoleucine; Leucine; Methionine; Phenylalanine; Proline; Purines; Serine; Thiamine; Thiazoles; Threonine; Thymine; Tyrosine; Uracil; Valine | 1968 |
Effect of aliphatic amino acids and citric acid cycle compounds on early thiamine production by thiazoleless mutant of Escherichia coli.
Topics: Alanine; Amino Acids; Ammonium Chloride; Aspartic Acid; Carbon Isotopes; Culture Media; Dicarboxylic Acids; Escherichia coli; Formates; Fumarates; Glucose; Glutamates; Lysine; Malates; Mutation; Pyruvates; Serine; Succinates; Thiamine; Thiazoles; Valine | 1968 |
Additive Edman degradation to sequence small peptides.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Chromatography, Gas; Hydantoins; Methods; Peptides; Phenylalanine; Serine; Silicones; Thiazoles; Valine | 1971 |
Studi on siomycin. II. The composition and degradation products of siomycin A.
Topics: Acetaldehyde; Alanine; Amino Acids; Anti-Bacterial Agents; Butyrates; Carbon; Chemical Phenomena; Chemistry; Cysteine; Optical Rotatory Dispersion; Oxidation-Reduction; Propionates; Pyruvates; Quinazolines; Thiazoles; Threonine; Valine | 1969 |
Update on HIV transmission and pathogenesis.
Topics: Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; Disease Models, Animal; Genes, env; HIV; HIV Infections; HIV Protease Inhibitors; HIV-1; HLA-A Antigens; HLA-DR Antigens; HLA-DR Serological Subtypes; Humans; Macaca; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Simian Immunodeficiency Virus; Thiazoles; Time Factors; Valine; Virulence; Virus Latency; Virus Replication | 1995 |
AIDS drugs lurch towards market.
Topics: Acquired Immunodeficiency Syndrome; Drug Approval; HIV Protease; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Isoquinolines; Pyridines; Quinolines; Ritonavir; Saquinavir; Thiazoles; United States; United States Food and Drug Administration; Valine | 1995 |
Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure.
Topics: Amino Acid Sequence; Binding Sites; Carbamates; Cloning, Molecular; Drug Resistance, Microbial; HIV Protease; HIV Protease Inhibitors; HIV-1; Indinavir; Isoquinolines; Kinetics; Methylurea Compounds; Mutagenesis, Site-Directed; Oligopeptides; Point Mutation; Pyridines; Quinolines; Recombinant Proteins; Saquinavir; Structure-Activity Relationship; Thiazoles; Valine | 1995 |
ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.
Topics: Administration, Oral; Animals; Antiviral Agents; Bile; Bile Ducts; Binding Sites; Biological Availability; Capsules; Female; HIV Protease; HIV Protease Inhibitors; HIV-1; HIV-2; Humans; Injections, Intravenous; Macaca fascicularis; Male; Metabolic Clearance Rate; Models, Molecular; Molecular Structure; Pyridines; Rats; Rats, Sprague-Dawley; Ritonavir; Tablets; Thiazoles; Tissue Distribution; Valine | 1995 |
Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor.
Topics: Amino Acid Sequence; Antiviral Agents; Computer Simulation; Drug Resistance; HIV Protease; HIV Protease Inhibitors; HIV-1; Molecular Sequence Data; Mutagenesis, Site-Directed; Ritonavir; Structure-Activity Relationship; Thiazoles; Valine | 1995 |
Conformational behaviour of the antineoplastic peptide dolastatin-10 and of two mutated derivatives.
Topics: Amino Acids; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Depsipeptides; Hydrogen Bonding; Models, Molecular; Molecular Structure; Mollusca; Mollusk Venoms; Mutation; Oligopeptides; Protein Conformation; Pyrrolidines; Solutions; Structure-Activity Relationship; Thiazoles; Valine; Water | 1995 |
Protease inhibitors fly through FDA.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Approval; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; Valine | 1996 |
Protestors say "non" to HIV drug lottery.
Topics: Acquired Immunodeficiency Syndrome; France; HIV Protease Inhibitors; Humans; Public Opinion; Ritonavir; Thiazoles; Valine | 1996 |
New HIV drugs approved after some deal-making.
Topics: HIV Infections; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; United States; United States Food and Drug Administration; Valine | 1996 |
Protease inhibitors show promise in HIV infection.
Topics: Antiviral Agents; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; Thiazoles; Valine | 1996 |
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.
Topics: Antiviral Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cell Survival; Half-Life; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Kinetics; Models, Biological; Regression Analysis; Ritonavir; RNA, Viral; Thiazoles; Valine; Viremia; Virion; Virus Replication | 1996 |
New drugs for HIV infection.
Topics: Antiviral Agents; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Stavudine; Thiazoles; Valine; Zalcitabine | 1996 |
Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.
Topics: Animals; Antiviral Agents; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; HIV Protease Inhibitors; Humans; Microsomes, Liver; Rabbits; Ritonavir; Thiazoles; Valine | 1996 |
Results on new AIDS drugs bring cautious optimism.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Therapy, Combination; HIV; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; RNA, Viral; Thiazoles; Valine; Viremia | 1996 |
Japan's anti-AIDS drug arsenal slowly expands.
Topics: Antiviral Agents; Drug Approval; Drugs, Investigational; HIV Infections; Humans; Japan; Physicians; Protease Inhibitors; Public Opinion; Ritonavir; Thiazoles; United States; Valine; Zalcitabine | 1996 |
Protease inhibitors: a tale of two companies.
Topics: Acquired Immunodeficiency Syndrome; Animals; Antiviral Agents; Chemistry, Pharmaceutical; Controlled Clinical Trials as Topic; Drug Approval; Drug Design; Drug Industry; HIV; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; Thiazoles; United States; United States Food and Drug Administration; Valine | 1996 |
A new class of anti-HIV drugs debuts.
Topics: Drug Costs; Drug Resistance; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Pyridines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir.
Topics: Codon; Genotype; HIV; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Mutation; Phenotype; Ritonavir; Thiazoles; Valine | 1996 |
Ritonavir for advanced HIV infection.
Topics: Antiviral Agents; HIV Infections; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; Valine | 1996 |
Second protease inhibitor approved for HIV therapy.
Topics: Drug Approval; HIV Infections; HIV Protease Inhibitors; Ritonavir; Thiazoles; Valine | 1996 |
Renal failure after treatment with ritonavir.
Topics: Acute Kidney Injury; Adult; Antiviral Agents; HIV Protease Inhibitors; Humans; Male; Middle Aged; Ritonavir; Thiazoles; Valine | 1996 |
[For the first time a combination of 2 protease inhibitors investigated].
Topics: Antiviral Agents; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Isoquinolines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
Antiretroviral drugs: new agents, new combinations line up against HIV.
Topics: Antiviral Agents; Australia; Didanosine; Drug Therapy, Combination; Europe; HIV; HIV Infections; Humans; Lamivudine; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Thiazoles; United States; Valine; Zalcitabine; Zidovudine | 1996 |
Abbott: major protest over lack of access.
Topics: Acquired Immunodeficiency Syndrome; CD4 Lymphocyte Count; Drug Industry; HIV Protease Inhibitors; Illinois; Pharmaceutical Services; Public Opinion; Ritonavir; Social Responsibility; Thiazoles; Valine | 1995 |
Protease inhibitor trials moving to next phase.
Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Nelfinavir; Quinolines; Ritonavir; Saquinavir; Stavudine; Thiazoles; Valine; Virus Replication | 1995 |
Abbott cancels arm of protease inhibitor trial.
Topics: Clinical Trials as Topic; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; Valine | 1995 |
Abbott agrees to implement a compassionate use program for Ritonavir.
Topics: Acquired Immunodeficiency Syndrome; Altruism; HIV Infections; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; Valine | 1995 |
Update on HIV protease inhibitors.
Topics: Antiviral Agents; CD4 Lymphocyte Count; Clinical Trials as Topic; Didanosine; Drug Design; Drug Therapy, Combination; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Phosphorylation; Pyridines; Quinolines; Ritonavir; Saquinavir; Substrate Specificity; Thiazoles; Valine; Zalcitabine; Zidovudine | 1995 |
Abbott protease inhibitor in combination: sustained viral load drop.
Topics: Clinical Trials as Topic; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Ritonavir; RNA, Viral; Thiazoles; Valine | 1995 |
Ritonavir, saquinavir combination--& warning.
Topics: Dose-Response Relationship, Drug; Drug Resistance, Microbial; Half-Life; HIV Infections; Humans; Inactivation, Metabolic; Isoquinolines; Mutation; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1995 |
Abbott agrees to expanded access for ritonavir.
Topics: Acquired Immunodeficiency Syndrome; Dosage Forms; Drug Therapy, Combination; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1995 |
Expanded access for experimental AIDS drugs.
Topics: Acquired Immunodeficiency Syndrome; Drug Approval; Drugs, Investigational; HIV Protease Inhibitors; Humans; Ritonavir; Thalidomide; Thiazoles; Valine | 1995 |
Conference looks at HIV drug resistance.
Topics: Antiviral Agents; Carbamates; CD4 Lymphocyte Count; Drug Resistance, Microbial; Furans; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Sulfonamides; Thiazoles; Valine; Viremia; Zalcitabine; Zidovudine | 1995 |
Ritonavir expanded access.
Topics: CD4 Lymphocyte Count; Drug Interactions; HIV Infections; HIV Protease Inhibitors; Humans; Patient Selection; Ritonavir; Thiazoles; Valine | 1995 |
Kids studies.
Topics: Child; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; Thiazoles; Valine | 1995 |
Abbott protease inhibitor lottery in January, CD4 under 50--registration now.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; CD4 Lymphocyte Count; HIV Protease Inhibitors; Humans; Patient Selection; Ritonavir; Thiazoles; Valine | 1995 |
Ritonavir: expanded access begins, warning on drug interactions.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; HIV Protease Inhibitors; Humans; Liver; Ritonavir; Thiazoles; Valine | 1996 |
2000 PWAs to get ritonavir via expanded access.
Topics: Acquired Immunodeficiency Syndrome; CD4 Lymphocyte Count; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; Valine | 1995 |
Protease inhibitor approvals: will people be cut off drug? Followup studies proposal needs support.
Topics: Acquired Immunodeficiency Syndrome; Drug Approval; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; Thiazoles; United States Food and Drug Administration; Valine | 1996 |
Protease inhibitors shine in triple combinations.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; CD4 Lymphocyte Count; Dose-Response Relationship, Drug; Drug Therapy, Combination; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Pyridines; Ritonavir; Thiazoles; Valine; Zalcitabine; Zidovudine | 1996 |
Ritonavir, Abbott protease inhibitor, approved.
Topics: Acquired Immunodeficiency Syndrome; Drug Approval; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; Valine | 1996 |
Protease inhibitors: patient education critical.
Topics: Acquired Immunodeficiency Syndrome; Drug Interactions; Drug Resistance, Microbial; HIV; HIV Protease Inhibitors; Humans; Indinavir; Patient Education as Topic; Pyridines; Ritonavir; Thiazoles; Valine | 1996 |
Highlights from the FDA antiviral drug advisory committee meetings, February 27-March 1, 1996.
Topics: Antiviral Agents; Device Approval; Drug Approval; Drug Therapy, Combination; Growth Hormone; HIV Infections; HIV Protease Inhibitors; Human Growth Hormone; Humans; Indinavir; Pyridines; Recombinant Proteins; Ritonavir; Thiazoles; United States; United States Food and Drug Administration; Valine; Virology | 1996 |
Europe out of step with the US.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Didanosine; Drug Costs; Europe; HIV Protease Inhibitors; Humans; Isoquinolines; Lamivudine; Quinolines; Ritonavir; Saquinavir; Thiazoles; United States; Valine; Zalcitabine; Zidovudine | 1996 |
How 'bout that ritonavir?
Topics: Acquired Immunodeficiency Syndrome; Drug Approval; HIV Protease Inhibitors; Ritonavir; Thiazoles; Valine | 1996 |
Three days that shook the world.
Topics: Antiviral Agents; Drug Approval; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; Thiazoles; United States; United States Food and Drug Administration; Valine; Zidovudine | 1996 |
Ritonavir (Norvir).
Topics: HIV Infections; HIV Protease Inhibitors; Humans; Ritonavir; Thiazoles; Valine | 1996 |
Protease inhibitors-at-a-glance.
Topics: HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Pyridines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
Update on protease inhibitors.
Topics: Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Placebos; Pyridines; Ritonavir; Stavudine; Thiazoles; Valine | 1996 |
Ritonavir: first to prolong survival.
Topics: Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine; Zalcitabine; Zidovudine | 1996 |
Ritonavir/saquinavir trial announced.
Topics: Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
Two protease inhibitors given high expectations.
Topics: Acquired Immunodeficiency Syndrome; Clinical Trials as Topic; Drug Therapy, Combination; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
FDA approves 2 new protease inhibitors: ritonavir (Norvir) and Crixivan (Indinavir sulfate). Food and Drug Administration.
Topics: Drug Approval; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; Thiazoles; United States; United States Food and Drug Administration; Valine | 1996 |
Starting ritonavir.
Topics: Diet; HIV Protease Inhibitors; Humans; Nausea; Ritonavir; Thiazoles; Valine | 1996 |
Nipping HIV in the bud.
Topics: Antiviral Agents; CD4 Lymphocyte Count; Didanosine; DNA, Viral; Drug Resistance, Microbial; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Lamivudine; Pyridines; Quinolines; Ritonavir; Saquinavir; Stavudine; Thiazoles; Valine; Virus Replication; Zalcitabine; Zidovudine | 1996 |
Two new protease inhibitors approved by FDA. Food and Drug Administration.
Topics: Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Pyridines; Ritonavir; Thiazoles; United States; United States Food and Drug Administration; Valine | 1996 |
Protease inhibitors.
Topics: Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Isoquinolines; Pyridines; Quinolines; Ritonavir; Saquinavir; Thiazoles; Valine | 1996 |
Ritonavir plus saquinavir: two trials with different results.
Topics: CD4 Lymphocyte Count; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Isoquinolines; Quinolines; Ritonavir; RNA, Viral; Saquinavir; Thiazoles; Valine | 1996 |
A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.
Topics: Alanine; alpha-Synuclein; Amino Acid Motifs; Benzothiazoles; Circular Dichroism; Escherichia coli; Glycine; Humans; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Peptides; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Synucleins; Thiazoles; Time Factors; Valine | 2003 |
PHARMACOLOGICAL AND TOXICOLOGICAL COMPOUNDS AS PROTECTIVE OR THERAPEUTIC AGENTS AGAINST RADIATION INJURY IN EXPERIMENTAL ANIMALS. I. EFFECTS OF 2-IMINO-THIAZOLIDINE-4-CARBOXYLIC ACID ON THE RADIOPROTECTIVE ACTIVITY OF VARIOUS CHEMICAL AGENTS. REP NO. 51.
Topics: Amino Acid Oxidoreductases; Animals; Animals, Laboratory; beta-Aminoethyl Isothiourea; Mercaptoethylamines; Mice; Pharmacology; Propiophenones; Radiation Injuries; Radiation-Protective Agents; Research; Thiazoles; Thiazolidines; Valine | 1964 |
Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.
Topics: Aldehydes; Boron Compounds; Chemistry, Organic; Indicators and Reagents; Leucine; Molecular Structure; Stereoisomerism; Thiazoles; Valine | 2004 |
Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.
Topics: Adipocytes; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Glucose; Cell Differentiation; Cells, Cultured; Chlorocebus aethiops; Drug Evaluation, Preclinical; Gene Expression Regulation; Imidazoles; Insulin; Irbesartan; Losartan; Male; Mice; Models, Molecular; Myoblasts; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Structure-Activity Relationship; Telmisartan; Tetrazoles; Thiazoles; Thiazolidinediones; Thiazolidines; Transcription Factors; Triglycerides; Valine; Valsartan; Weight Gain | 2004 |
The relationship of the human glutathione S-transferase P1 polymorphism and chemotherapeutic sensitivity in head and neck squamous carcinoma.
Topics: Alleles; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Multiple; Exons; Genotype; Glutathione Transferase; Head and Neck Neoplasms; Heterozygote; Humans; Inhibitory Concentration 50; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Tetrazolium Salts; Thiazoles; Valine | 2004 |
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats.
Topics: Administration, Oral; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Callithrix; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Female; Fumarates; Heart Rate; Imidazoles; Injections, Intravenous; Male; Piperazines; Rats; Rats, Inbred SHR; Renin; Telemetry; Tetrazoles; Thiazoles; Valine; Valsartan | 2005 |
Role of GSK-3beta activity in motor neuronal cell death induced by G93A or A4V mutant hSOD1 gene.
Topics: Alanine; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Survival; Collagen Type XI; Cytochromes c; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heat-Shock Proteins; Humans; Hybrid Cells; Indoles; Motor Neurons; Mutagenesis; Neuroblastoma; Phosphatidylinositol 3-Kinases; Point Mutation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Trypan Blue; Valine | 2005 |
Effects of the sequence and size of non-polar residues on self-assembly of amphiphilic peptides.
Topics: Alanine; Amino Acid Motifs; Amyloid; Benzothiazoles; Circular Dichroism; Congo Red; Gene Library; Glycine; Hydrogel, Polyethylene Glycol Dimethacrylate; Isoleucine; Leucine; Macromolecular Substances; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Molecular; Peptides; Phenylalanine; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Secondary; Temperature; Thiazoles; Ultraviolet Rays; Valine; X-Ray Diffraction | 2005 |
Role of N-terminal familial mutations in prion protein fibrillization and prion amyloid propagation in vitro.
Topics: Amyloid; Benzothiazoles; Escherichia coli; Genetic Predisposition to Disease; Humans; In Vitro Techniques; Kinetics; Methionine; Microscopy, Atomic Force; Molecular Conformation; Mutation; Plasmids; Polymorphism, Genetic; Prion Diseases; Prions; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Time Factors; Valine | 2006 |
Molecular heterosis of prion protein beta-oligomers. A potential mechanism of human resistance to disease.
Topics: Alleles; Amyloid; Benzothiazoles; Circular Dichroism; Heterozygote; Homozygote; Humans; Hybrid Vigor; Kinetics; Methionine; Prion Diseases; Prions; Thiazoles; Valine | 2006 |
Synthesis of libraries of thiazole, oxazole and imidazole-based cyclic peptides from azole-based amino acids. A new synthetic approach to bistratamides and didmolamides.
Topics: Alanine; Amino Acids; Animals; Chemistry, Organic; Chemistry, Pharmaceutical; Imidazoles; Models, Chemical; Oxazoles; Peptides, Cyclic; Thiazoles; Urochordata; Valine | 2007 |
Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency.
Topics: Alleles; Amino Acid Motifs; Animals; Benzamides; Cell Line; Dasatinib; Drug Resistance, Neoplasm; Drug Therapy, Combination; Fusion Proteins, bcr-abl; Genotype; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mutation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Sensitivity and Specificity; Thiazoles; Valine | 2007 |
Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity.
Topics: Anesthetics, Inhalation; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Administration Schedule; Embryo, Mammalian; Isoflurane; L-Lactate Dehydrogenase; Leucine; Mutation; Neural Inhibition; Neurons; Presenilin-1; Rats; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Valine | 2007 |
Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes.
Topics: Binding Sites; Carboxy-Lyases; Carboxylic Acids; Circular Dichroism; Crystallography, X-Ray; Escherichia coli; Glutamates; Kinetics; Models, Molecular; Mutation; Phosphates; Protein Structure, Tertiary; Thiamine; Thiazoles; Valine | 2008 |
A new amyloid-like beta-aggregate with amyloid characteristics, except fibril morphology.
Topics: Amino Acid Substitution; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Death; Cell Line, Tumor; Congo Red; Mice; Models, Biological; Mutant Proteins; Mutation; Peptides; Proline; Protein Structure, Quaternary; Protein Structure, Secondary; Thiazoles; Time Factors; Valine | 2009 |
Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Antigens, Surface; Brain Injuries; Bumetanide; Caspases; Cell Count; Choline; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Humans; Imaging, Three-Dimensional; In Vitro Techniques; Luminescent Proteins; Male; Membrane Glycoproteins; Mice; Mice, Transgenic; Microscopy, Confocal; Nerve Net; Neurons; Phosphinic Acids; Propanolamines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Regression Analysis; Signal Transduction; Sodium Potassium Chloride Symporter Inhibitors; Statistics, Nonparametric; Thiazoles; Thioglycolates; Time Factors; Valine | 2012 |
Influence of the valine zipper region on the structure and aggregation of the basic leucine zipper (bZIP) domain of activating transcription factor 5 (ATF5).
Topics: Activating Transcription Factors; Benzothiazoles; Circular Dichroism; Fluorescence; Humans; Leucine Zippers; Mutation; Nuclear Magnetic Resonance, Biomolecular; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary; Spectroscopy, Fourier Transform Infrared; Thiazoles; Valine | 2012 |
Mouse prion protein polymorphism Phe-108/Val-189 affects the kinetics of fibril formation and the response to seeding: evidence for a two-step nucleation polymerization mechanism.
Topics: Alleles; Animals; Benzothiazoles; Circular Dichroism; Dose-Response Relationship, Drug; Kinetics; Mice; Microscopy, Electron; Phenylalanine; Polymers; Polymorphism, Genetic; Prion Diseases; Prions; Protein Conformation; Recombinant Proteins; Thiazoles; Time Factors; Valine | 2013 |
Hepatitis C viral entry inhibitors prolong viral suppression by replication inhibitors in persistently-infected Huh7 cultures.
Topics: Antiviral Agents; Carbamates; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Synergism; Hepacivirus; Hepatocytes; Humans; Imidazoles; Macrocyclic Compounds; Pyrrolidines; Quinolines; Thiazoles; Time Factors; Valine; Viral Load; Virus Internalization; Virus Replication | 2013 |
BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Australia; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Genotype; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory, Episodic; Methionine; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles; Valine | 2013 |
Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1).
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport; Boron Compounds; Drug Design; HeLa Cells; Humans; Mice; Molecular Docking Simulation; Oligopeptides; Peptides, Cyclic; Peptidomimetics; Photobleaching; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles; Valine | 2014 |
Minimum costs for producing hepatitis C direct-acting antivirals for use in large-scale treatment access programs in developing countries.
Topics: Aminoisobutyric Acids; Anti-HIV Agents; Antiviral Agents; Carbamates; Developing Countries; Drug Industry; Drug Therapy, Combination; Health Services Accessibility; Hepacivirus; Hepatitis C; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Leucine; Oligopeptides; Proline; Pyrrolidines; Quinolines; Ribavirin; Simeprevir; Sofosbuvir; Sulfonamides; Thiazoles; Uridine Monophosphate; Valine | 2014 |
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.
Topics: Amino Acids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Design; Humans; Molecular Docking Simulation; Thiazoles; Valine | 2014 |
Isolation and assessment of the in vitro anti-tumor activity of smenothiazole A and B, chlorinated thiazole-containing peptide/polyketides from the Caribbean sponge, Smenospongia aurea.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; MCF-7 Cells; Molecular Structure; Porifera; Thiazoles; Valine | 2015 |
Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Heterografts; Humans; Mice; Neoplasm Transplantation; Neoplasms; Paclitaxel; Peptidomimetics; Thiazoles; Treatment Outcome; Valine | 2017 |
Total syntheses of smenothiazoles A and B.
Topics: Alkynes; Stereoisomerism; Thiazoles; Valine | 2017 |
Singlet Oxygen Photooxidation of Peptidic Oxazoles and Thiazoles.
Topics: Kinetics; Oxazoles; Oxidation-Reduction; Peptides; Peptides, Cyclic; Photochemical Processes; Singlet Oxygen; Thiazoles; Valine | 2019 |
African scientists race to test COVID drugs - but face major hurdles.
Topics: Africa; Amides; Amodiaquine; Artesunate; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Cytidine; Drug Approval; Drug Evaluation, Preclinical; Drug Repositioning; Drug Therapy, Combination; Humans; Hydroxylamines; Imidazoles; Ivermectin; Naphthyridines; Nitro Compounds; Pregnenediones; Pyrazines; Pyrrolidines; Ritonavir; Sample Size; Thiazoles; Valine; World Health Organization | 2021 |