Compounds > valine

valine and ppi 2458

valine has been researched along with ppi 2458 in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (83.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernier, SG; Clark, E; Doyle, B; Hannig, G; Labenski, MT; Lazarus, DD; Thompson, CD; Westlin, WF1
Bernier, SG; Hannig, G; Taghizadeh, N; Thompson, CD; Westlin, WF1
Bernier, SG; Hannig, G; Karp, RM; Labenski, MT; Lazarus, DD; Lorusso, J; Qiu, D; Thompson, CD; Wakefield, JD; Westlin, WF1
Clark, EJ; Cooper, AC; Hannig, G; Hoyt, JG; Karp, RM; Labenski, MT; Murray, MJ; Taghizadeh, NR; Thompson, CD; Westlin, WF1
Bernier, SG; Clark, E; Doyle, B; Hannig, G; Hoyt, JG; Karp, RM; Lorusso, J; Westlin, WF1
Brahn, E; Lainer-Carr, D1
Bainbridge, J; Binks, M; Essex, D; Madden, L; Malhotra, R; Paleolog, EM1
Bernier, SG; Clark, EJ; Doyle, EG; Hannig, G; Hoyt, JG; Karp, RM; Labenski, MT; Lazarus, DD; Lorusso, J; Rogers, AB; Thompson, CD; Wakefield, JD; Westlin, WF1
Binks, M; Buckton, J; Grimley, RL; Malhotra, R; Priest, RC; Sims, M; Spaull, J1
Banquerigo, ML; Brahn, E; Lee, S; Schoettler, N1
Ashraf, S; Mapp, PI; Walsh, DA1
Arico-Muendel, CC; Belanger, B; Benjamin, D; Blanchette, HS; Caiazzo, TM; Centrella, PA; DeLorey, J; Doyle, EG; Gradhand, U; Griffin, ST; Hill, S; Labenski, MT; Morgan, BA; O'Donovan, G; Prasad, K; Skinner, S; Taghizadeh, N; Thompson, CD; Wakefield, J; Westlin, W; White, KF1

Reviews

1 review(s) available for valine and ppi 2458

ArticleYear
Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis.
    Nature clinical practice. Rheumatology, 2007, Volume: 3, Issue:8

    Topics: Angiopoietins; Cyclohexanes; Epoxy Compounds; Fatty Acids, Unsaturated; Humans; Hypoxia-Inducible Factor 1; Integrin alphaVbeta3; Neovascularization, Pathologic; O-(Chloroacetylcarbamoyl)fumagillol; Receptor, TIE-2; Sesquiterpenes; Synovitis; Tubulin Modulators; Valine; Vascular Endothelial Growth Factor A

2007

Trials

1 trial(s) available for valine and ppi 2458

ArticleYear
Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:4

    Topics: Aminopeptidases; Angiogenesis Inhibitors; Animals; Drug Administration Schedule; Epoxy Compounds; Humans; Leukocytes; Lymph Nodes; Lymphoma, Non-Hodgkin; Metalloendopeptidases; Microsomes, Liver; Rats; Structure-Activity Relationship; Thymus Gland; Valine

2013

Other Studies

10 other study(ies) available for valine and ppi 2458

ArticleYear
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Jul-20, Volume: 101, Issue:29

    Topics: Aminopeptidases; Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Cyclohexanes; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids, Unsaturated; Humans; Metalloendopeptidases; Proliferating Cell Nuclear Antigen; Rats; Sesquiterpenes; Synovial Membrane; Valine

2004
Methionine aminopeptidases type I and type II are essential to control cell proliferation.
    Journal of cellular biochemistry, 2005, Aug-15, Volume: 95, Issue:6

    Topics: Aminopeptidases; Cell Proliferation; Cells, Cultured; Cyclohexanes; Down-Regulation; Epithelial Cells; Epoxy Compounds; Fatty Acids, Unsaturated; Humans; Methionyl Aminopeptidases; RNA, Small Interfering; Saccharomyces cerevisiae; Sesquiterpenes; Transcription, Genetic; Umbilical Veins; Valine

2005
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
    International journal of oncology, 2006, Volume: 28, Issue:4

    Topics: Administration, Oral; Aminopeptidases; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Epoxy Compounds; Glycoproteins; Humans; Male; Melanins; Melanoma, Experimental; Methionyl Aminopeptidases; Mice; Mice, Inbred C57BL; Valine

2006
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Apr-15, Volume: 12, Issue:8

    Topics: Aminopeptidases; Animals; B-Lymphocytes; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Germinal Center; Humans; Lymphocyte Count; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Macaca fascicularis; Metalloendopeptidases; Mice; Mice, SCID; Proto-Oncogene Proteins c-bcl-2; Time Factors; Valine; Xenograft Model Antitumor Assays

2006
Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458.
    Arthritis and rheumatism, 2007, Volume: 56, Issue:3

    Topics: Aminopeptidases; Animals; Arthritis, Rheumatoid; Bone Resorption; Cell Differentiation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Epoxy Compounds; Female; Glycoproteins; Humans; Joints; Osteoclasts; Peptidoglycan; Polysaccharides; Rats; Rats, Inbred Lew; Severity of Illness Index; Valine

2007
Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition.
    Arthritis research & therapy, 2007, Volume: 9, Issue:6

    Topics: Aminopeptidases; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Endothelial Cells; Epoxy Compounds; Fibroblast Growth Factor 2; Glycoproteins; Humans; Male; Methionyl Aminopeptidases; Mice; Mice, Inbred DBA; Neovascularization, Pathologic; Protease Inhibitors; Synovial Membrane; Valine; Vascular Endothelial Growth Factor A

2007
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008, Volume: 57, Issue:1

    Topics: Aminopeptidases; Animals; Arthritis, Rheumatoid; Body Weight; Bone Resorption; Cell Differentiation; Cells, Cultured; Epoxy Compounds; Female; Joints; Metalloendopeptidases; Mice; Osteoclasts; Protease Inhibitors; Rats; Rats, Inbred Lew; Valine

2008
Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation.
    Clinical and experimental immunology, 2009, Volume: 155, Issue:3

    Topics: Aminopeptidases; Animals; Antibodies; B-Lymphocytes; Callithrix; Cell Differentiation; Depression, Chemical; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Germinal Center; Humans; Immunoglobulin G; Immunohistochemistry; Lymphocyte Count; Metalloendopeptidases; Mice; Models, Animal; Species Specificity; Spleen; Valine

2009
Involution of collagen-induced arthritis with an angiogenesis inhibitor, PPI-2458.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:2

    Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Arthritis, Experimental; Biological Availability; Collagen Type II; Epoxy Compounds; Flow Cytometry; Injections, Intravenous; Injections, Subcutaneous; Molecular Structure; Neovascularization, Pathologic; Rats; Rats, Inbred Strains; Valine

2009
Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Carrageenan; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Epoxy Compounds; Fibroblast Growth Factor 2; Hindlimb; Injections, Intra-Articular; Joints; Macrophages; Male; Neovascularization, Pathologic; Rats; Rats, Wistar; Synovial Membrane; Synovitis; Valine

2010