valine has been researched along with glutamic acid in 421 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (17.10) | 18.7374 |
| 1990's | 65 (15.44) | 18.2507 |
| 2000's | 138 (32.78) | 29.6817 |
| 2010's | 133 (31.59) | 24.3611 |
| 2020's | 13 (3.09) | 2.80 |
| Authors | Studies |
|---|---|
| Akamatsu, M; Asao, M; Fujita, T; Iwamura, H | 1 |
| Bonnemain, JL; Chollet, JF; Delétage, C; Faucher, M; Miginiac, L | 1 |
| Kinoshita, H; Shimizu, K | 1 |
| Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
| Anthony, A; Augustyn, E; Bauer, J; Campbell, J; Chien, HC; Colas, C; Finke, K; Flint, A; Fotiadis, D; Giacomini, KM; Hall, C; Hansen, L; Heeren, N; Hernandez, C; Schlessinger, A; Springer, S; Stoner, L; Thomas, AA; Venteicher, B; Zur, AA | 1 |
| Fong, TM; Huang, RR; Strader, CD; Yu, H | 1 |
| Felipo, V; Grisolía, S; Hermenegildo, C; Marcaida, G; Miñana, MD | 1 |
| Bajaj, SP; Birktoft, JJ; Brackmann, HH; Ludwig, M; Olek, K; Sabharwal, AK; Smith, KJ | 1 |
| Bangalore, L; Bormann, BJ; Cao, H; Stern, DF | 1 |
| Lam, HM; Winkler, ME | 1 |
| Aulak, K; Bissler, J; Davis, AE; Eldering, E; Hack, CE; Kramer, J; Parad, RB; Rosen, FS; Stecklein, HP; Strunk, RC | 1 |
| Baudin, V; Bihoreau, MT; Bohn, B; Dumoulin, A; Edelstein, SJ; Kister, J; Lacaze, N; Marden, M; Poyart, C; Schaad, O | 1 |
| Bullock, R; Butcher, SP; Chen, MH; Kendall, L; McCulloch, J | 1 |
| Monaghan, DT | 1 |
| Bessman, SP; Memon, RA; Mohan, C | 1 |
| Ishiura, S; Maruyama, K; Tagawa, K; Usami, M; Yamao-Harigaya, W | 1 |
| Fukushima, R; Kizu, A; Miyagishi, T; Ono, T; Yoshida, Y | 1 |
| Shilo, BZ; Wides, RJ; Zak, NB | 1 |
| Clements, JD; Jahr, CE; Lester, RA; Westbrook, GL | 1 |
| Adams, RN; Bunney, BS; Gruen, RJ; Moghaddam, B; Roth, RH | 1 |
| Goodman, JC; Robertson, CS; Simpson, RK | 1 |
| Bruce, D; Carrell, RW; Daly, M; Harper, PL; O'Meara, A; Perry, DJ; Price, J | 1 |
| Baron, BM; McDonald, IA; Miller, F; Muench, D; White, HS; Whitten, JP | 1 |
| Bauman, MJ; Mawhinney, TD; Peterson, E; Rarey, KE; Raymer, SL; Schweitzer, VG; Woodson, BT | 1 |
| Aanonsen, LM; Wilcox, GL | 1 |
| Cherubini, E; King, AE; Nistri, A | 1 |
| Boxer, SG; Gray, HB; Varadarajan, R; Zewert, TE | 1 |
| Choquet, CG; Kamekura, M; Kushner, DJ | 1 |
| Barbeito, L; Cheramy, A; Girault, JA; Glowinski, J; Godeheu, G; Pittaluga, A | 1 |
| Hayashi, H; Inoue, Y; Kagamiyama, H; Kuramitsu, S; Morino, Y | 1 |
| Hoehn, K; White, TD | 1 |
| Bode-Greuel, KM; Singer, W | 1 |
| Chytil, A; Courtney, M; Crystal, RG; Curiel, DT | 1 |
| Prasad, KU; Urry, DW; Zhang, H | 1 |
| Hauber, W; Schmidt, WJ | 1 |
| Choi, DW; Hartley, DM | 1 |
| Caspary, DM; Faingold, CL; Hoffmann, WE | 1 |
| Nagamatsu, A; Ohki, H; Shimeno, H; Soeda, S | 1 |
| Brandt-Rauf, PW; Chen, JM; Pincus, MR | 1 |
| Canellakis, ES; Fong, WF; Ortiz, JG; Rinehart, CA; Viceps-Madore, D | 1 |
| King, AE; Nistri, A; Rovira, C | 1 |
| Lenzen, S; Panten, U; Schmidt, W | 1 |
| Hablitz, JJ | 1 |
| Henneberry, RC; Novelli, A | 1 |
| Fujita, S; Hayashi, A; Imamura, T; Kawaguchi, T; Kobayashi, Y; Naritomi, Y; Ohta, Y; Saito, S; Wada, Y | 1 |
| Baudry, M; Cummins, JT; Kessler, M; Lynch, G; Way, S | 1 |
| Jahr, CE; Yoshioka, K | 1 |
| Nelson, PG; Pun, RY; Westbrook, GL | 1 |
| Hertz, L; Lacoste, L; Lapointe, J | 1 |
| Freeman, JA; Langdon, RB | 1 |
| Costa, E; Nicoletti, F; Wroblewski, JT | 1 |
| Gordon, FJ | 1 |
| Fagg, GE; Foster, AC | 1 |
| Bliss, TV; Errington, ML; Lynch, MA | 1 |
| Ito, K; Izumi, Y; Kato, H; Kudo, Y; Miyakawa, H; Ogura, A | 1 |
| Foster, AC; Wong, EH | 1 |
| Crepel, F; Dupont, JL; Gardette, R | 1 |
| Javitt, DC; Jotkowitz, A; Sircar, R; Zukin, SR | 1 |
| Beckwith, J; Buc, H; Ebright, RH; Kolb, A; Krakow, JS; Kunkel, TA | 1 |
| Adachi, K; Asakura, T; Harano, T; Kim, J; Travitz, R | 1 |
| Crunelli, V; Kelly, JS; Leresche, N; Pirchio, M | 1 |
| Choi, DW; Peters, S | 1 |
| Choi, DW; Goldberg, MP; Pham, PC; Weiss, JH | 1 |
| Choi, DW; Koh, JY; Peters, S | 1 |
| Hagiwara, S; Hirano, T | 1 |
| Kloog, Y; Nadler, V; Sokolovsky, M | 1 |
| Foster, PA; Fulcher, CA; Houghten, RA; Zimmerman, TS | 1 |
| Krishtal, OA; Smirnov, SV | 1 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Kihara, M; Kubo, T | 1 |
| Connick, JH; Stone, TW | 1 |
| Bargmann, CI; Weinberg, RA | 1 |
| Jones, AW; Olverman, HJ; Watkins, JC | 1 |
| King, AE; Thompson, SW; Urban, L; Woolf, CJ | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Raigorodsky, G; Urca, G | 1 |
| Lovinger, DM; Weight, FF | 1 |
| Schäfer, G; Schauder, P | 1 |
| Amiconi, G; Antonini, E; Ascoli, F; Civalleri, L; Condò, SG; Santucci, R | 1 |
| Collins, JF; Curry, K; Perkins, MN; Stone, TW | 1 |
| Ikeda, H; Sheardown, MJ | 1 |
| Curtis, DR; Hansen, JJ; Krogsgaard-Larsen, P; Lauridsen, J; Leah, JD; Peet, MJ | 1 |
| Lehmann, J; Scatton, B | 1 |
| Davies, J; Watkins, JC | 1 |
| Jackson, S; Potter, LM; Stas, RJ | 1 |
| Belov, AP; Davidova, EG; Rachinskiĭ, VV | 1 |
| Caldecourt, MA; Palmer, TN; Sugden, MC | 1 |
| Hansson, E | 1 |
| Mayer, ML; Westbrook, GL | 1 |
| King, AE; Wheal, HV | 1 |
| Imamura, T; Imoto, T; Kagimoto, M; Matsuo, T; Naito, Y; Sugihara, J; Yamada, H; Yokota, E | 1 |
| Buchhalter, JR; Djali, S; Robinson, MB | 1 |
| Chung, SH; Premkumar, L | 1 |
| Harper, AE; Torres, N; Tovar, AR | 1 |
| Baglia, FA; Gurr, JA; Jameson, BA; Seaman, FS; Walsh, PN | 1 |
| Becquet, D; Deprez, P; Fache, MP; Faudon, M; Giraud, P; Héry, F; Héry, M | 1 |
| Nakao, S; Noda, H; Ohsugi, M | 1 |
| Joshi, AA; McDonald, MJ | 1 |
| Bruin, T; Hayden, MR; Jansen, H; Kastelein, JJ; Mulder, WJ; Tuzgöl, S; van den Ende, AE | 1 |
| Bonner, K; Gennarelli, L; Rorke, LB; Sutton, LN; Wang, Z; Wehrli, SL; Zimmerman, R | 1 |
| Berglund, S; Landin, B; Lindoff, B | 1 |
| Ahrens, F; Mosenthin, R; Sauer, WC | 1 |
| Bovill, EG; Long, GL; Lu, D | 1 |
| Inao, S; Kuchiwaki, H; Sugita, K; Yamamoto, M; Yoshida, K | 1 |
| Araki, H; Fujii, J; Hirano, M; Nagai, Y; Okamoto, K; Sonobe, M; Taniguchi, N; Ueno, S | 1 |
| Bonneau, PR; Brömme, D; Lachance, P; Storer, AC | 1 |
| Kamp, RM; Kluge, B; Menkhaus, M; Ullrich, C; Vater, J; Vollenbroich, D | 1 |
| Freire, CA; Greene, LJ; McNamara, JC; Rosa, JC | 1 |
| Huber, RE; Roth, NJ | 1 |
| Baudin, V; Kister, J; Lesecq, S; Marden, MC; Pagnier, J; Poyart, C | 1 |
| Lee, S; Naime, D; Okubo, Y; Redman, C; Reid, M; Sistonen, P; Son, S; Wu, X | 1 |
| Berrino, L; D'Amico, M; de Novellis, V; Pizzirusso, A; Rossi, F | 1 |
| Brew, K; Grobler, JA; Malinovskii, VA; Tian, J | 1 |
| Gekko, K; Hayashi, H; Kagamiyama, H; Ohmae, E; Tamura, Y; Ueno, H | 1 |
| Esaki, N; Hong, SP; Kim, HS; Ro, HS; Seo, HJ; Soda, K; Sung, MH; Yoshimura, T | 1 |
| Fitzgerald, LM; Szmant, AM | 1 |
| Ikeda, M; Ishida, O; Kikuchi, A; Kishida, S; Matsuura, Y; Murai, H; Okazaki-Kishida, M | 1 |
| Furukawa, K; Holtsberg, FW; Keller, JN; Mattson, MP; Steiner, MR; Steiner, SM | 1 |
| Belloni, E; Gaudenz, K; Muenke, M; Roessler, E; Scherer, SW; Tsui, LC; Vargas, F | 1 |
| Agard, DA; Delos, SE; Hernandez, LD; Peters, RJ; White, JM; Young, JA | 1 |
| Buelow, R; Cornejo, MC; Gao, L; Iyer, S; Maines, M; McCoubrey, W; Woo, J | 1 |
| Astermark, J; Björk, I; Persson, KE; Stenflo, J | 1 |
| Cameron, IM; Gaffney, D; Hoffs, MS; O'Reilly, DS; Packard, CJ; Stewart, G | 1 |
| Friedman, AL; Geeves, MA; Manstein, DJ; Spudich, JA | 1 |
| Isralewitz, B; Krammer, A; Lu, H; Schulten, K; Vogel, V | 1 |
| French, G; Granzier, H; Greaser, M; Trombitás, K | 1 |
| Centner, T; Jockusch, H; Kolmerer, B; Labeit, D; Labeit, S; Millevoi, S; Morell, J; Olivieri, N; Pastore, A; Witt, CC | 1 |
| Dewar, JB; Gaillard, MC; Green, SL; Halkas, A; Song, E | 1 |
| Nanduri, B; Zimniak, P | 1 |
| Suzuki, K; Tanaka, T; Yamada, T | 1 |
| Matsuura, K; Nagashima, KV; Osyczka, A; Shimada, K | 1 |
| Overman, SA; Thomas, GJ | 1 |
| Arrendondo-Vega, FX; Buckley, R; Conley, ME; El Dahr, J; Hershfield, MS; Notarangelo, LD; Roifman, C; Santisteban, I | 1 |
| Lu, Y; Wang, X | 1 |
| Mele, A; Oliverio, A; Roullet, P; Sargolini, F | 1 |
| Gonda, TJ; McCormack, MP | 1 |
| Attane, F; Beaudry, P; Besson, G; Delasnerie-Lauprêtre, N; Hannequin, D; Laplanche, JL; Manivet, P; Peoc'h, K | 1 |
| Kötter, R; Luhmann, HJ; Staiger, JF; Zilles, K | 1 |
| Balashov, SP; Ebrey, TG; Gennis, RB; Kandori, H; Maeda, A; Tomson, FL | 1 |
| Dwyer, JJ; García-Moreno E, B; Gittis, AG; Karp, DA; Lattman, EE; Spencer, DS; Stites, WE | 1 |
| Cookson, WO; Donnadieu, E; Jouvin, MH; Kinet, JP | 1 |
| Doyle, SA; Fung, SY; Koshland, DE | 1 |
| Brown, PR; Karmali, A; Tata, R | 1 |
| Dutra-Filho, CS; Santos, CE; Souza, DO; Tasca, CI; Tavares, RG; Wajner, M | 1 |
| Pielak, GJ; Wang, X | 1 |
| Kaback, HR; Smirnova, IN; Weinglass, AB | 1 |
| Agut, H; Angleraud, F; Calvez, V; Delaugerre, C; Huraux, JM; Katlama, C; Mouroux, M; Simon, A; Yvon-Groussin, A | 1 |
| Goldsmith, PK; Hu, J; Reyes-Cruz, G; Spiegel, AM | 1 |
| Cruz, WS; Kwon, G; Marshall, CA; McDaniel, ML; Xu, G | 1 |
| Heinzle, E; Wittmann, C | 1 |
| Han, H; Liu, G; Shangguan, D; Zhao, R; Zhao, Y | 1 |
| Castro, SL; Zigmond, MJ | 1 |
| Guo, Y; Sánchez, C; Udin, SB | 1 |
| Epand, RF; Epand, RM; Martin, I; Ruysschaert, JM | 1 |
| Baranov, V; Hörstedt, P; Ippel, HJ; Lundgren, E; Olofsson, A; Wijmenga, S | 1 |
| Altaba, S; Voelker, F | 1 |
| Ahuja, N; Bhatnagar, R; Kumar, P | 1 |
| Kazuta, Y; Kohsaka, S; Kudo, Y; Matsuda, A; Mishina, M; Nakajima-Iijima, S; Nakamura, T; Shuto, S; Uchino, S; Watanabe, W | 1 |
| Bollen, A; Ferrari, RP; Ghibaudi, EM; Moguilevsky, N; Suriano, G; Watanabe, S | 1 |
| Basiuk, VA; Douda, J | 1 |
| Hu, JY; Zhao, ZQ | 1 |
| Abe, H; Iwasaki, T | 1 |
| Barber, KR; Giusti, J; Grant, CW; Morrow, MR; Sharpe, S | 1 |
| Naumann, TA; Reznikoff, WS | 1 |
| Berger, MB; King, MC; Lemmon, MA; Mendrola, JM | 1 |
| Ballard, BT; Chait, BT; Manning, JM; Padovan, JC; Popowicz, AM; Yagami, T | 1 |
| Wang, GD; Zhuo, M | 1 |
| Bertram, D; Coote, JH | 1 |
| Akita, RW; Penuel, E; Sliwkowski, MX | 1 |
| Goto, N; Igarashi, T; Morisaki, H; Yamamoto, A | 1 |
| Chaudhury, K; Guha, SK; Jagannathan, NR; Sharma, U | 1 |
| Bohác, M; Damborský, J; Koca, J; Monincová, M; Nagata, Y; Prokop, M; Prokop, Z; Tsuda, M | 1 |
| Allison, WS; Bandyopadhyay, S; Huynh, HG; Ren, H; Valder, CR | 1 |
| Arcari, P; Cantiello, P; De Paola, B; Fiengo, A; Masullo, M; Vitagliano, L; Zagari, A | 1 |
| Glick, SD; Maisonneuve, IM; Shoblock, JR; Sullivan, EB | 1 |
| Funahashi, HO; Kikuchi, A; Nakagawa, Y; Nakao, A; Sawada, M; Suda, N; Suzuki, M; Takami, Y; Yoshida, S | 1 |
| Belay, G; Budka, H; Hainfellner, JA; Jarius, C; Kovacs, GG; Mitrova, E | 1 |
| Beck, DO; Bukys, MA; Kalafatis, M; Singh, LS | 1 |
| Oliver, J; Palou, A; Proenza, AM; Roca, P | 1 |
| Ito, S; Kanmatsuse, K; Katsunuma, N; Tsukamoto, K | 1 |
| Chau, DT; Gonzalez, LE; Harrison, T; Hernandez, L; Hoebel, BG; Moreno, SA; Rada, P; Tucci, S | 1 |
| Ma, K; Wang, K | 1 |
| Kaneko, H; Minagawa, H; Shimada, J | 1 |
| Hoshino, M; Nakashima, T; Sokabe, M; Tatsumi, H | 1 |
| FEREN, CJ; HEDRICK, LR | 1 |
| MURAI, A; TACHIKAWA, Y | 1 |
| GERULAT, BF; MAURER, PH; PINCHUCK, P | 1 |
| EDMAN, P; NIALL, H | 1 |
| Carmignoto, G; Fellin, T; Gobbo, S; Pozzan, T; Sebelin, A; Zonta, M | 1 |
| Fujita, H; Funck, T; Granzier, H; Labeit, D; Labeit, S; Lahmers, S; Watanabe, K; Witt, C; Wu, Y | 1 |
| Rodehutscord, M; Timmler, R | 1 |
| Baillat, D; Lelièvre, E; Lionneton, F; Soncin, F; Stehelin, D | 1 |
| Bungo, T; Izumi, T; Kawamura, K; Ueda, H | 1 |
| Feldman, S; Weidenfeld, J | 1 |
| El-Mashtoly, SF; Fujiwara, K; Hamada, N; Imamoto, Y; Kataoka, M; Kumauchi, M; Sasaki, J; Tokunaga, F; Unno, M; Yamauchi, S | 1 |
| Bartanusz, V; Gaillard, RC; Kiss, JZ; Muller, D; Streit, P; Vutskits, L | 1 |
| Avenia, N; Cavaliere, A; Elisei, R; Fadda, G; Falorni, A; Marino, C; Martinelli, M; Moretti, S; Pacini, F; Pascucci, R; Pinchera, A; Pontecorvi, A; Puxeddu, E; Ribacchi, R; Romei, C; Rossi, ED; Santeusanio, F | 1 |
| Ahn Jo, S; Carp, RI; Jang, MK; Jeong, BH; Ju, YR; Kim, YS; Lee, HD; Lee, KH; Lee, YJ; Nam, JH; Park, KY | 1 |
| de Lima, AD; Opitz, T; Voigt, T | 1 |
| Cooper, JA; Herrick, TM | 1 |
| Brüschweiler, R; Zhang, F | 1 |
| Mangiavacchi, S; Wolf, ME | 1 |
| Lin, TB | 1 |
| Morris, RG; O'Carroll, CM | 1 |
| Clarke, VR; Collingridge, GL | 1 |
| Albert, A; Ariño, J; Barceló, A; Marquina, M; Muñoz, I; Ruiz, A | 1 |
| Kwak, EJ; Lim, SI | 1 |
| Barde, YA; Bibel, M; Goetz, M; Korte, M; Richter, J; Schrenk, K; Staiger, V; Tucker, KL | 1 |
| Dahlin-Huppe, K; Fukushi, J; Makagiansar, IT; Mustelin, T; Stallcup, WB; Williams, S | 1 |
| Kanno, T; Nagata, T; Nishizaki, T; Tanaka, A; Yaguchi, T; Yamamoto, S | 1 |
| Akana, J; Gerlt, JA; Rayment, I; Wise, EL; Yew, WS | 1 |
| Bikoff, JB; Burette, A; Greenberg, ME; Harrar, D; Paradis, S; Tavazoie, S; Tolias, KF; Weinberg, RJ | 1 |
| Imagawa, T; Kaya, S; Sakaguchi, K; Taniguchi, K; Yamamoto, T | 1 |
| Barany, F; Elenitsas, R; Seykora, J; Turner, DJ; Zirvi, MA | 1 |
| Chen, M; Cheng, T; Ou, SH; Wu, T; Xia, NS; Xu, CY; Zhang, J; Zhang, T | 1 |
| Aller, P; Garnier, N; Genest, M; Samna Soumana, O | 1 |
| Cohen-Solal, C; de Jesus Ferreira, MC; Guiramand, J; Martin, A; Récasens, M; Vignes, M | 1 |
| Kajikawa, H; Kurihara, M; Mitsumori, M; Tajima, K | 1 |
| Coons, S; Ellsworth, K; Johnson, E; Kerrigan, JF; Kim, DY; Lue, LF; Nowak, L; Rekate, H; Rho, JM; St John, PA; Wu, J; Xu, L | 1 |
| Delgado-García, JM; Navarro-López, Jde D; Yajeya, J | 1 |
| Gao, J; Hu, Z; Jin, G; Liu, J; Qing, J; Shen, H; Wang, S; Wang, X; Zhai, X | 1 |
| Fallon, JR; Taylor, AB | 1 |
| Alevra, X; Christodoulou, K; Georgiou, DM; Hadjisavvas, A; Kleopa, KA; Kyriakides, T; Nicolaou, P; Zamba-Papanicolaou, E | 1 |
| Kremer, BP; Rabelink, GM; Sinke, RJ; van de Warrenburg, BP; Vlak, MH | 1 |
| Higashiyama, K; Koizumi, K; Park, EY | 1 |
| Chen, R; Chen, S; Ge, D; Gu, D; Huang, J; Li, B; Qiang, B; Su, S | 1 |
| Avenia, N; Beck-Peccoz, P; Bottici, V; Cavaliere, A; Cirello, V; Elisei, R; Faviana, P; Fugazzola, L; Mannavola, D; Moretti, S; Pacini, F; Pinchera, A; Puxeddu, E; Romei, C; Rossi, S; Santeusanio, F; Sculli, M | 1 |
| Abbe, P; Bahadoran, P; Bailet, O; Ballotti, R; Baron, V; Bertolotto, C; Gaggioli, C; Ortonne, JP; Robert, G; Spadafora, A; Tartare-Deckert, S | 1 |
| Adhya, S; Choi, EJ; Dimitriadis, EK; Guo, F; Kar, S; Kotova, SL | 1 |
| Angel, C; Dobrovic, A; Dowling, JP; Kelly, JW; Liu, W; Magee, J; Mason, G; McArthur, GA; Murray, WK; Trivett, M; Wolfe, R | 1 |
| Colinet, H; Gagneul, D; Kostál, V; Lalouette, L; Renault, D | 1 |
| Hirokawa, M; Ito, Y; Miyauchi, A; Takano, T; Yoshida, H | 1 |
| Burghardt, I; Cederbaum, LS; Gromov, EV; Köppel, H | 1 |
| Bak, LK; Johansen, ML; Schousboe, A; Waagepetersen, HS | 2 |
| Adeyeye, EI; Aluko, AO; Asaolu, SS | 1 |
| Ennis, M; Hayar, A | 1 |
| Bai, D; Gong, XQ; Zabek, RL | 1 |
| Chatterjee, N; Daugherty, SE; Fallin, MD; Hayes, RB; Huang, WY; Isaacs, WB; Platz, EA; Shugart, YY; Welch, R | 1 |
| Amato, MC; Cabibi, D; Galluzzo, A; Gebbia, N; Giordano, C; Martorana, A; Pizzolanti, G; Richiusa, P; Rodolico, V; Russo, A | 1 |
| Almeida, FC; Da Poian, AT; Juliano, L; Juliano, MA; Lima, CS; Sarzedas, CG; Valente, AP | 1 |
| Andorf, JL; Bird, AC; Brantley, MA; Chen, LL; Holder, GE; Isaak, EM; Jenkins, SA; Michaelides, M; Stone, EM; Webster, AR | 1 |
| Arnold, S; Brown, MA; Buchanan, D; Chenevix-Trench, G; Couch, FJ; Farrugia, DJ; Goldgar, DE; Healey, S; Henderson, BR; Lakhani, SR; Lovelock, PK; Mok, MT; Spurdle, AB; Tavtigian, SV | 1 |
| Cui, Y; Guadagno, TM | 1 |
| Dubey, SK; Misra, K; Narain, U; Pati, U; Sharma, AK | 1 |
| Araque, A; Navarrete, M | 1 |
| Decker, MW; Man, K; Parikh, V; Sarter, M | 1 |
| Cheung, M; Madhunapantula, SV; Robertson, GP; Sharma, A | 1 |
| Blower, PE; Durinck, S; Futreal, AP; Ikediobi, ON; Reimers, M; Stratton, MR; Weinstein, JN | 1 |
| Cens, T; Charnet, P; Leyris, JP | 1 |
| Danger, G; Ross, D | 1 |
| Farb, DH; Gibbs, TT; Whittaker, MT | 1 |
| Dalla Palma, M; Desai, B; Egyhazi, S; Elder, DE; Flaherty, KT; Hansson, J; Herlyn, M; King, AJ; Lioni, M; Nathanson, KL; Smalley, KS; Van Belle, P; Wu, H; Xiao, M | 1 |
| Elder, DE; Flaherty, KT; Herlyn, M; Letrero, R; Nathanson, KL; Nguyen, TK; Smalley, KS; Van Belle, P; Villanueva, J; Wang, Y; Xiao, M | 1 |
| Fukushima, M; Higashiyama, T; Hirokawa, M; Inoue, H; Ito, Y; Kihara, M; Kobayashi, K; Maruo, R; Matsuzuka, F; Miya, A; Miyauchi, A; Morita, S; Takamura, Y; Takano, T; Tomoda, C; Uruno, T; Yabuta, T; Yoshida, H | 1 |
| Hai, T; Kim, TJ; Lee, JS; Suh, JW | 1 |
| Chen, PS; Chen, YJ; Lin, JS; Liu, HM; Lyou, JY; Tzeng, CH | 1 |
| Ackman, JB; Aniksztejn, L; Becq, H; Ben-Ari, Y; Cardoso, C; Crépel, V; Pellegrino, C; Represa, A | 1 |
| Di, S; Franco, A; Maxson, MM; Tasker, JG | 1 |
| Chen, DY; Liang, KC; Liu, TL | 1 |
| Fahrenholz, F; Schmitt, U; Schroeder, A | 1 |
| Gelperin, A; Ghatpande, AS | 1 |
| Espinosa, F; Kavalali, ET | 1 |
| Cheong, JW; Choi, JR; Kim, SJ; Lee, KA; Lee, KW; Park, TS; Song, J; Song, S; Suh, B | 1 |
| Baldwin, RL; Bequette, BJ; El-Kadi, SW; McLeod, KR; Sunny, NE | 1 |
| Bortone, D; Polleux, F | 1 |
| Blankenship, AG; Copenhagen, DR; Edwards, RH; Feller, MB; Ford, KJ; Johnson, J; Seal, RP | 1 |
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| Chen, MJ; Chu, CC; Lin, CL; Lin, PY; Shyr, MH; Yang, KL; Yang, TC | 1 |
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| Chu, J; Li, YY; Liu, BH; Ye, BC; Yin, BC; Yin, CY; Yu, H; Yu, WB; Zhang, SL; Zhang, Y | 1 |
| Ahmed, SH; Lindsey, ML | 1 |
| Chung, CC; MacLeod, BA; Puil, E; Ries, CR; Schwarz, SK; Wang, JT | 1 |
| Kiess, W; Klammt, J; Kratzsch, J; Kruis, T; Müller, E; Pfäffle, R; Schlicke, M; Schmidt, G; van de Leur, HS; Wallborn, T; Wüller, S | 1 |
| Bermúdez-Rattoni, F; Guzmán-Ramos, K; Moreno-Castilla, P; Osorio-Gómez, D | 2 |
| Creemers, GJ; Fariña-Sarasqueta, A; Lemmens, VEPP; Moerland, E; Rutten, HJT; van den Brule, AJC; van Lijnschoten, G | 1 |
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| Baggiani, A; Basolo, F; Berti, P; Elisei, R; Giannini, R; Lupi, C; Miccoli, M; Miccoli, P; Sensi, E; Torregrossa, L; Vitti, P | 1 |
| Bell, E; Bradley, MJ; Marion, J; Wacker, SA | 1 |
| Mier, JW; Panka, DJ; Sullivan, RJ | 1 |
| Fang, J; Ji, K; Jin, Y; Liu, YL; Ojihara, T; Wang, X; Watanabe, K; Watanabe, S; Wei, KW; Xuan, K | 1 |
| Hodin, R; Lawler, J; Nucera, C; Parangi, S | 1 |
| Colledge, WH; d'Anglemont de Tassigny, X; Herbison, AE; Liu, X; Millar, R; Petersen, SL; Porteous, R | 1 |
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| Adam, C; Baulac, M; Clemenceau, S; Cohen, I; Huberfeld, G; Le Van Quyen, M; Menendez de la Prida, L; Miles, R; Pallud, J | 1 |
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| Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L | 1 |
| Coral, S; Fratta, E; Maio, M; Parisi, G; Sigalotti, L | 1 |
| Hwang, TS; Jang, YM; Kim, DL; Kim, SK; Lee, EJ; Song, KH | 1 |
| Bailey, J; Bell, E; Li, M; Neal, J; Powell, L; Sinanan, L; Smith, T | 1 |
| Chi, Z; Cui, C; Flaherty, KT; Guo, J; Kong, Y; Li, S; Mao, L; Sheng, X; Si, L; Xu, X | 1 |
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| Bolze, F; Kaifosh, P; Lee, PH; Losonczy, A; Lovett-Barron, M; Nicoud, JF; Sternson, SM; Sun, XH; Turi, GF; Zemelman, BV | 1 |
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| Liu, H; Pan, D; Xue, W; Yao, X; Zhang, W | 1 |
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| Chen, SR; Cheng, PW; Cheng, WH; Hong, LZ; Tseng, CJ; Wang, LL | 1 |
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| Chappé, C; Colin, C; Figarella-Branger, D; Fina, F; Forest, F; Lena, G; Loundou, A; Mercurio, S; Nanni-Metellus, I; Padovani, L; Scavarda, D | 1 |
| Barbacioru, C; Chudova, DI; Friedman, L; Kennedy, GC; Kloos, RT; Lanman, RB; LiVolsi, VA; Pagan, M; Reynolds, JD; Rosai, J; Tom, EY; Walsh, PS; Wilde, JI; Wong, M | 1 |
| Batchelor, TT; Borger, DR; Chi, AS; Dias-Santagata, D; Ellisen, LW; Iafrate, AJ; Louis, DN; Yang, D | 1 |
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| Bonci, A; Cho, SL; de Lecea, L; Deisseroth, K; Kempadoo, KA; Leinninger, GM; Magnani, F; Myers, MG; Stuber, GD; Tourino, C; Zhang, F | 1 |
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| Hirato, J; Ikota, H; Kurihara, H; Nagaishi, M; Nakazato, Y; Nobusawa, S; Ogawa, A; Okura, N; Yokoo, H | 1 |
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| Guan, H; Liu, R; Liu, X; Murugan, AK; Qu, S; Shan, Z; Sheng, C; Shi, X; Sun, H; Teng, W; Wang, Y; Xing, M; Yu, H; Zhu, G | 1 |
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| Carman, CV; Chung, S; Clohessy, J; De Angelis, AM; Duquette, M; Durante, O; Dvorak, HF; Fadda, G; Farsetti, A; Fletcher, C; Henske, EP; Husain, A; Karreth, FA; Kutzner, H; Lawler, J; Lombardi, CP; Macconaill, LE; Martinelli, R; Mentzel, T; Nanni, S; Nucera, C; Palescandolo, E; Pandolfi, PP; Parker, JA; Pontecorvi, A; Priolo, C; Sadow, PM | 1 |
| LeBoeuf, NR; Lee, EQ; Ruland, S; Santagata, S; Wen, PY | 1 |
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| Allan, RW; Drane, WE; Ivey, AM; Kaye, FJ; Mendenhall, WM | 1 |
| Bishop, J; Du, J; El-Naggar, AK; Liu, R; Liu, X; Luo, Y; Qu, S; Shan, Z; Shi, X; Sun, H; Teng, W; Wang, E; Xing, M; Yang, X; Zhao, J; Zhu, G | 1 |
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| Brastianos, PK; Santagata, S | 1 |
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| Benedict, JJ; DeConti, R; Gibney, GT; Gonzalez, RJ; Kudchadkar, RR; McCardle, T; Messina, JL; Sloot, S; Smalley, KS; Sondak, VK; Turner, LM; Weber, JS; Zager, JS | 1 |
| Bouvet, M; Diaz-Perez, JA; Nguyen, QT; Orosco, RK; Savariar, EN; Tsien, RY; Weissbrod, PA | 1 |
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| Feng, SF; Huang, Y; Liu, G; Shi, TY; Wei, MX; Wu, HT; Zhang, YX; Zhou, WX | 1 |
| Collingridge, GL; Jia, Z; Leung, C; Liu, A; Meng, Y; Park, P; Qi, J; Xia, S; Xie, W; Zhou, Z | 1 |
| Akagi, A; Iwasaki, Y; Kitamoto, T; Mimuro, M; Yamada, M; Yoshida, M | 1 |
| Adachi, Y; Bando, H; Ebi, H; Faber, AC; Kitai, H; Kotani, H; Tomida, S; Voon, DC; Yano, S; Yoshino, T | 1 |
| Camelo-Piragua, S; Chinnaiyan, A; Koschmann, C; Leung, D; McFadden, K; Mody, R; Pratt, D; Venneti, S | 1 |
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| Bernal, B; Blesbois, E; Castaño, C; Esteso, MC; Gil, MG; Gutiérrez-Adán, A; López-Sebastián, A; Pérez-Cerezales, S; Santiago-Moreno, J; Toledano-Díaz, A; Woelders, H | 1 |
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8 review(s) available for valine and glutamic acid
| Article | Year |
|---|---|
On the excitatory post-synaptic potential evoked by stimulation of the optic tract in the rat lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aminobutyrates; Animals; Aspartic Acid; Calcium; Dipeptides; Glutamates; Glutamic Acid; In Vitro Techniques; Male; N-Methylaspartate; Neurons; Optic Nerve; Rats; Rats, Inbred Strains; Synapses; Thalamic Nuclei; Valine | 1987 |
Pseudo-replication of [GADV]-proteins and origin of life.
Topics: Alanine; Genetic Code; Glutamic Acid; Glycine; Models, Genetic; Origin of Life; Polymerization; Proteins; RNA; Valine | 2009 |
The BRAFV600E mutation: what is it really orchestrating in thyroid cancer?
Topics: Amino Acid Substitution; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; Cell Transformation, Neoplastic; Glutamic Acid; Humans; Models, Biological; Mutation, Missense; Proto-Oncogene Proteins B-raf; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Valine | 2010 |
BRAF V600E mutation and its association with clinicopathological features of papillary thyroid cancer: a meta-analysis.
Topics: Age Factors; Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Female; Genetic Association Studies; Genetic Predisposition to Disease; Glutamic Acid; Humans; Lymphatic Metastasis; Male; Mutation, Missense; Proto-Oncogene Proteins B-raf; Sex Characteristics; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Burden; Valine | 2012 |
Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal.
Topics: Animals; Animals, Newborn; Bicuculline; Biophysics; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutamic Acid; Muscimol; Patch-Clamp Techniques; Potassium Channel Blockers; Pregnanolone; Presynaptic Terminals; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Tetraethylammonium; Valine | 2013 |
BRAF Immunohistochemistry Using Clone VE1 is Strongly Concordant with BRAF(V600E) Mutation Test in Papillary Thyroid Carcinoma.
Topics: Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Cloning, Molecular; DNA Mutational Analysis; Glutamic Acid; Humans; Immunohistochemistry; Molecular Diagnostic Techniques; Mutation, Missense; Proto-Oncogene Proteins B-raf; Reproducibility of Results; Sensitivity and Specificity; Thyroid Cancer, Papillary; Thyroid Neoplasms; Valine | 2015 |
ENDOCRINE TUMORS: BRAF V600E mutations in papillary craniopharyngioma.
Topics: Carcinoma, Papillary; Clinical Trials, Phase II as Topic; Craniopharyngioma; Endocrine Gland Neoplasms; Glutamic Acid; Humans; MAP Kinase Signaling System; Pituitary Neoplasms; Point Mutation; Proto-Oncogene Proteins B-raf; Valine | 2016 |
A Systematic Review and Meta-Analysis of the Diagnostic Performance of BRAF V600E Immunohistochemistry in Thyroid Histopathology.
Topics: Amino Acid Substitution; Biomarkers, Tumor; Cytodiagnosis; Diagnosis, Differential; Glutamic Acid; Humans; Immunohistochemistry; Mutation, Missense; Predictive Value of Tests; Prognosis; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Thyroid Gland; Thyroid Neoplasms; Thyroid Nodule; Valine | 2019 |
4 trial(s) available for valine and glutamic acid
| Article | Year |
|---|---|
Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.
Topics: Adenoma; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Case-Control Studies; Colonic Neoplasms; Female; Genetic Variation; Genotype; Glutamic Acid; Glycine; Haplotypes; Humans; Ibuprofen; Leucine; Lysine; Male; Methionine; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Racemases and Epimerases; Rectal Neoplasms; Serine; Valine | 2007 |
The BRAF(V600E) mutation is associated with malignant ultrasonographic features in thyroid nodules.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Biopsy, Fine-Needle; Carcinoma; Carcinoma, Papillary; Diagnosis, Differential; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Male; Middle Aged; Mutation; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroid Nodule; Ultrasonography; Valine; Young Adult | 2011 |
Reproducible and sustained efficacy of targeted therapy with vemurafenib in patients with BRAF(V600E)-mutated Erdheim-Chester disease.
Topics: Adult; Aged; Erdheim-Chester Disease; Female; Fluorodeoxyglucose F18; Glutamic Acid; Humans; Indoles; Male; Middle Aged; Molecular Targeted Therapy; Mutation; Positron-Emission Tomography; Proto-Oncogene Proteins B-raf; Radiopharmaceuticals; Skin; Sulfonamides; Treatment Outcome; Valine; Vemurafenib | 2015 |
Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Disease-Free Survival; DNA Mismatch Repair; Female; Fluorouracil; Follow-Up Studies; Glutamic Acid; Humans; Infusions, Intravenous; Injections, Intravenous; Kaplan-Meier Estimate; Leucovorin; Male; Middle Aged; Mutation; Neoplasm Staging; Odds Ratio; Organoplatinum Compounds; Prognosis; Proto-Oncogene Proteins B-raf; Treatment Outcome; Valine | 2015 |
409 other study(ies) available for valine and glutamic acid
| Article | Year |
|---|---|
Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives.
Topics: Amino Acids; Humans; Mathematics; Peptides; Structure-Activity Relationship; Taste | 1987 |
Synthesis and structure-activity relationships of some pesticides with an alpha-amino acid function.
Topics: Amino Acids; Drug Carriers; Hydrogen-Ion Concentration; Lysine; Membrane Potentials; Pesticides; Solubility; Structure-Activity Relationship; Threonine | 1997 |
Prediction of the GTPase activities by using the semiempirical molecular orbital theory.
Topics: Amino Acid Substitution; Chemistry, Physical; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Hydrolysis; Kinetics; Models, Chemical; Mutagenesis, Site-Directed; Proto-Oncogene Proteins p21(ras); Thermodynamics | 1998 |
Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
Topics: Amino Acid Transport Systems; Antiporters; Escherichia coli Proteins; HEK293 Cells; Humans; Large Neutral Amino Acid-Transporter 1; Ligands; Molecular Docking Simulation; Phenylalanine; Stereoisomerism; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity | 2018 |
The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides.
Topics: Amino Acid Sequence; Animals; Cell Line; Glutamates; Glutamic Acid; Glycosylation; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Neurokinin B; Rats; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Structure-Activity Relationship; Substance P; Transfection; Valine | 1992 |
Acute ammonia toxicity is mediated by the NMDA type of glutamate receptors.
Topics: Ammonia; Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Male; Mice; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1992 |
Hemophilia B caused by five different nondeletion mutations in the protease domain of factor IX.
Topics: Adult; Arginine; Binding Sites; Calcium; Exons; Factor IX; Glutamates; Glutamic Acid; Glutamine; Hemophilia B; Humans; Hydrogen Bonding; Middle Aged; Mutation; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Conformation; Serine Endopeptidases; Valine | 1992 |
A subdomain in the transmembrane domain is necessary for p185neu* activation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Membrane; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Glioma; Glutamates; Glutamic Acid; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuroblastoma; Precipitin Tests; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Rats; Receptor, ErbB-2; Signal Transduction; Valine | 1992 |
Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations.
Topics: Amino Acid Sequence; Base Sequence; Cell Division; Cloning, Molecular; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Glutamates; Glutamic Acid; Molecular Sequence Data; Mutagenesis, Insertional; Operon; Phenotype; Promoter Regions, Genetic; Pyridoxal Phosphate; Pyridoxaminephosphate Oxidase; RNA, Messenger; Sequence Homology; Suppression, Genetic; Transcription, Genetic; Tyrosine-tRNA Ligase; Valine | 1992 |
C1 inhibitor hinge region mutations produce dysfunction by different mechanisms.
Topics: Alanine; Amino Acid Sequence; Angioedema; Animals; Base Sequence; Cell Line; Cells, Cultured; Codon; Complement C1 Inactivator Proteins; Complement C1s; Fibroblasts; Glutamates; Glutamic Acid; Heterozygote; Humans; Kallikreins; Molecular Sequence Data; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Threonine; Transfection; Valine | 1992 |
Steric and hydrophobic determinants of the solubilities of recombinant sickle cell hemoglobins.
Topics: Alanine; Escherichia coli; Glutamates; Glutamic Acid; Hemoglobin, Sickle; Humans; Isoleucine; Mutagenesis, Site-Directed; Oxygen; Protein Conformation; Protein Engineering; Recombinant Proteins; Solubility; Structure-Activity Relationship; Valine | 1992 |
Correlation of the extracellular glutamate concentration with extent of blood flow reduction after subdural hematoma in the rat.
Topics: Amino Acids; Animals; Aspartic Acid; Blood Flow Velocity; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Disease Models, Animal; Glutamates; Glutamic Acid; Glutamine; Hematoma, Subdural; Male; Rats; Rats, Inbred Strains; Regression Analysis; Valine | 1991 |
Differential stimulation of [3H]MK-801 binding to subpopulations of NMDA receptors.
Topics: Animals; Autoradiography; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Glutamates; Glutamic Acid; In Vitro Techniques; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Thalamus; Valine | 1991 |
Amphibolic role of the Krebs cycle in the insulin-stimulated protein synthesis.
Topics: Alanine; Aminooxyacetic Acid; Animals; Carbon Dioxide; Carbon Radioisotopes; Citric Acid Cycle; Diaphragm; Glutamates; Glutamic Acid; Insulin; Ketoglutaric Acids; Liver; Male; Methionine; Muscles; Protein Biosynthesis; Rats; Rats, Inbred Strains; Valine | 1991 |
Mutation of Glu693 to Gln or Val717 to Ile has no effect on the processing of Alzheimer amyloid precursor protein expressed in COS-1 cells by cDNA transfection.
Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Cell Line; Cloning, Molecular; Glutamates; Glutamic Acid; Glutamine; Humans; Immunoblotting; Isoleucine; Molecular Weight; Mutagenesis, Site-Directed; Recombinant Proteins; Transfection; Valine | 1991 |
Striatal N-methyl-D-aspartate receptors in haloperidol-induced catalepsy.
Topics: Animals; Catalepsy; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Haloperidol; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Valine | 1991 |
Enhancement of tyrosine kinase activity of the Drosophila epidermal growth factor receptor homolog by alterations of the transmembrane domain.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chimera; Drosophila; Drosophila Proteins; Enzyme Activation; ErbB Receptors; Gene Expression Regulation, Enzymologic; Genes; Glutamates; Glutamic Acid; Molecular Sequence Data; Mutation; Phosphorylation; Protein Kinases; Protein-Tyrosine Kinases; Receptors, Invertebrate Peptide; Sequence Homology, Nucleic Acid; Signal Transduction; Valine | 1990 |
Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents.
Topics: Animals; Animals, Newborn; Aspartic Acid; Cells, Cultured; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Kinetics; N-Methylaspartate; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1990 |
Effect of L-glutamate on the release of striatal dopamine: in vivo dialysis and electrochemical studies.
Topics: Animals; Corpus Striatum; Dialysis; Dopamine; Glutamates; Glutamic Acid; Kinetics; Male; Membrane Potentials; Microelectrodes; Perfusion; Potassium; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1990 |
Spinal cord ischemia-induced elevation of amino acids: extracellular measurement with microdialysis.
Topics: Amino Acids; Animals; Asparagine; Chromatography, High Pressure Liquid; Dialysis; Extracellular Space; Glutamates; Glutamic Acid; Glycine; Ischemia; Kinetics; Rabbits; Spinal Cord; Taurine; Valine | 1990 |
Antithrombin Dublin (-3 Val----Glu): an N-terminal variant which has an aberrant signal peptidase cleavage site.
Topics: Adult; Amino Acid Sequence; Antithrombin III; Base Sequence; Endopeptidases; Exons; Gene Amplification; Genetic Carrier Screening; Genetic Variation; Glutamates; Glutamic Acid; Humans; Male; Membrane Proteins; Molecular Sequence Data; Oligonucleotide Probes; Reference Values; Serine Endopeptidases; Valine | 1990 |
(R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kindling, Neurologic; Mice; Mice, Inbred DBA; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 1990 |
Free amino acid analysis of guinea pig perilymph: a possible clinical assay for the PLF enigma?
Topics: Amino Acids; Animals; Arginine; Asparagine; Biomarkers; Chromatography; Chromatography, High Pressure Liquid; Fistula; Glutamates; Glutamic Acid; Glutamine; Guinea Pigs; Histidine; Isoleucine; Labyrinth Diseases; Leucine; Lysine; Perilymph; Phenylalanine; Spectrometry, Fluorescence; Threonine; Tyrosine; Valine | 1990 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
A study of amino acid-activated currents recorded from frog motoneurones in vitro.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anterior Horn Cells; Aspartic Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Ion Channels; Membrane Potentials; Motor Neurons; N-Methylaspartate; Neural Conduction; Oxadiazoles; Quisqualic Acid; Rana temporaria; Valine | 1987 |
Effects of buried ionizable amino acids on the reduction potential of recombinant myoglobin.
Topics: Asparagine; Aspartic Acid; Glutamates; Glutamic Acid; Heme; Humans; Mutation; Myoglobin; Oxidation-Reduction; Protein Conformation; Recombinant Proteins; Thermodynamics; Valine | 1989 |
In vitro protein synthesis by the moderate halophile Vibrio costicola: site of action of Cl- ions.
Topics: Bacterial Proteins; Betaine; Carbon Radioisotopes; Chlorides; Glutamates; Glutamic Acid; Hot Temperature; Kinetics; Leucine; Phenylalanine; Poly U; Protein Biosynthesis; Ribosomes; Valine; Vibrio | 1989 |
Activation of the bilateral corticostriatal glutamatergic projection by infusion of GABA into thalamic motor nuclei in the cat: an in vivo release study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cats; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Injections; Male; Synaptic Transmission; Thalamic Nuclei; Valine | 1989 |
[Arg292----Val] or [Arg292----Leu] mutation enhances the reactivity of Escherichia coli aspartate aminotransferase with aromatic amino acids.
Topics: Amino Acid Sequence; Arginine; Aspartate Aminotransferases; Aspartic Acid; Catalysis; Circular Dichroism; Cloning, Molecular; Escherichia coli; Glutamates; Glutamic Acid; Kinetics; Leucine; Mutation; Protein Conformation; Spectrophotometry; Structure-Activity Relationship; Substrate Specificity; Valine | 1989 |
Evoked release of endogenous adenosine from rat cortical slices by K+ and glutamate.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Potassium; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1989 |
The development of N-methyl-D-aspartate receptors in cat visual cortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Binding, Competitive; Cats; Glutamates; Glutamic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine; Visual Cortex | 1989 |
Serum alpha 1-antitrypsin deficiency associated with the common S-type (Glu264----Val) mutation results from intracellular degradation of alpha 1-antitrypsin prior to secretion.
Topics: Alleles; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Amino Acid Sequence; Animals; Base Sequence; Genes; Glutamates; Glutamic Acid; Homozygote; Humans; Mice; Molecular Sequence Data; Monocytes; Mutation; Plasmids; RNA, Messenger; Transcription, Genetic; Transfection; Valine | 1989 |
Synthesis of 4% Glu-containing Val1 and Ile1-polypentapeptides: model protein systems for demonstrating mechanochemical coupling.
Topics: Glutamates; Glutamic Acid; Indicators and Reagents; Isoleucine; Magnetic Resonance Spectroscopy; Peptides; Valine | 1989 |
Effects of intrastriatal blockade of glutamatergic transmission on the acquisition of T-maze and radial maze tasks.
Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Glutamates; Glutamic Acid; Male; Psychomotor Performance; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Valine | 1989 |
Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Sodium; Valine | 1989 |
Effects of excitant amino acids on acoustic responses of inferior colliculus neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Inferior Colliculi; N-Methylaspartate; Parasympathomimetics; Rats; Rats, Inbred Strains; Valine | 1989 |
Further characterization of the binding of plasminogen to heparin: evidence for the involvement of lysine residues.
Topics: Binding Sites; Borohydrides; Chemical Phenomena; Chemistry; Fibrinolysin; Glutamates; Glutamic Acid; Heparin; Humans; Lysine; Plasminogen; Pyridoxal Phosphate; Valine | 1989 |
Conformational changes induced by the transforming amino acid substitution in the transmembrane domain of the neu oncogene-encoded p185 protein.
Topics: Amino Acid Sequence; Cell Membrane; Cell Transformation, Neoplastic; Glutamates; Glutamic Acid; Molecular Sequence Data; Oligopeptides; Protein Conformation; Proto-Oncogene Proteins; Receptor, ErbB-2; Structure-Activity Relationship; Thermodynamics; Valine | 1989 |
The effect of transport system A and N amino acids and of nerve and epidermal growth factors on the induction of ornithine decarboxylase activity.
Topics: Amino Acids; Aminoisobutyric Acids; Asparagine; Cells, Cultured; Enzyme Induction; Epidermal Growth Factor; Glutamates; Glutamic Acid; Nerve Growth Factors; Neuroblastoma; Ornithine Decarboxylase; Valine | 1985 |
The excitation of frog motoneurones in vitro by the glutamate analogue, DI-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), and the effect of amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Dicarboxylic; Animals; Glutamates; Glutamic Acid; Ibotenic Acid; Membrane Potentials; Motor Neurons; Oxadiazoles; Oxazoles; Quisqualic Acid; Rana temporaria; Receptors, AMPA; Receptors, Drug; Spinal Cord; Synapses; Synaptic Transmission; Valine | 1985 |
Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria.
Topics: Animals; Caproates; Cytoplasm; Glutamates; Glutamic Acid; Glutamine; Hemiterpenes; Islets of Langerhans; Keto Acids; Kinetics; Leucine; Mice; Mice, Obese; Mitochondria; Transaminases; Valine | 1985 |
Action of excitatory amino acids and their antagonists on hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; Iontophoresis; Manganese; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Tetrodotoxin; Valine | 1985 |
Veratrine- and glutamate-stimulated cGMP production in cultured rat neurons is differentially inhibited by imipramine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebellum; Cyclic GMP; Cytoplasmic Granules; Glutamates; Glutamic Acid; Imipramine; Neurons; Rats; Tetrodotoxin; Valine; Veratrine | 1985 |
Hemoglobin A2 Honai (alpha 2 delta 2(90)(F6)Glu----Val): a new delta chain variant.
Topics: Aged; Amino Acids; Blood Protein Electrophoresis; Chromatography, High Pressure Liquid; Electrophoresis, Starch Gel; Female; Glutamates; Glutamic Acid; Hemoglobin A; Hemoglobin A2; Humans; Pedigree; Peptide Fragments; Valine | 1985 |
Induction of glutamate binding sites in hippocampal membranes by transient exposure to high concentrations of glutamate or glutamate analogs.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Aminobutyrates; Animals; Aspartic Acid; Binding Sites; Chlorides; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Kinetics; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Saponins; Sodium; Valine | 1986 |
Ia afferent excitation of motoneurones in the in vitro new-born rat spinal cord is selectively antagonized by kynurenate.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Animals, Newborn; Carbachol; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kynurenic Acid; Male; Motor Neurons; Muscle Spindles; Neurons, Afferent; Rats; Spinal Cord; Spinal Nerve Roots; Strychnine; Synapses; Valine | 1986 |
Synaptic excitation in cultures of mouse spinal cord neurones: receptor pharmacology and behaviour of synaptic currents.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Glutamates; Glutamic Acid; Mice; Neurons; Pipecolic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Synapses; Time Factors; Valine | 1986 |
Non-linear kinetics of glutamyl-tRNA synthesis catalyzed by high molecular weight complexes from rat brain neuronal cells but not from glial cells.
Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Aspartic Acid; Brain; Catalysis; Cell Line; Glioma; Glutamates; Glutamic Acid; Glutamine; Kinetics; Macromolecular Substances; Mice; Molecular Weight; Neuroblastoma; Neuroglia; Rats; RNA, Transfer, Amino Acyl; Substrate Specificity; Valine | 1986 |
Antagonists of glutaminergic neurotransmission block retinotectal transmission in goldfish.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Cyprinidae; Dipeptides; Excitatory Amino Acid Antagonists; Glutamic Acid; Goldfish; In Vitro Techniques; Kynurenic Acid; Pipecolic Acids; Retina; Superior Colliculi; Synaptic Transmission; Time Factors; Valine | 1986 |
Magnesium ions inhibit the stimulation of inositol phospholipid hydrolysis by endogenous excitatory amino acids in primary cultures of cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Drug Synergism; Glutamates; Glutamic Acid; Hydrolysis; Inositol Phosphates; Kainic Acid; Magnesium; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Sugar Phosphates; Valine; Veratridine | 1987 |
Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aorta; Aspartic Acid; Electric Stimulation; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Injections, Intraventricular; Medulla Oblongata; Microinjections; N-Methylaspartate; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Synaptic Transmission; Valine | 1987 |
Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)aminophosphonovalerate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Depression, Chemical; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Synaptic Transmission; Valine | 1987 |
Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation and L-glutamate application.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Aspartic Acid; Benzofurans; Calcium; Cytoplasm; Egtazic Acid; Electric Stimulation; Fluorescent Dyes; Fura-2; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; N-Methylaspartate; Neural Pathways; Tetrodotoxin; Valine | 1987 |
The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Valine | 1987 |
Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids. An in vitro study.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebellar Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Purkinje Cells; Quisqualic Acid; Rats; Rats, Inbred Strains; Reaction Time; Valine | 1987 |
Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Glutamates; Glutamic Acid; Humans; Male; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Valine | 1987 |
Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP.
Topics: Amino Acid Sequence; Binding Sites; DNA, Bacterial; Escherichia coli; Glutamates; Glutamic Acid; Leucine; Mutation; Receptors, Cyclic AMP; Thermodynamics; Valine | 1987 |
Effect of amino acid at the beta 6 position on surface hydrophobicity, stability, solubility, and the kinetics of polymerization of hemoglobin. Comparisons among Hb A (Glu beta 6), Hb C (Lys beta 6), Hb Machida (Gln beta 6), and Hb S (Val beta 6).
Topics: Drug Stability; Glutamates; Glutamic Acid; Glutamine; Hemoglobin A; Hemoglobin C; Hemoglobin, Sickle; Hemoglobins; Hemoglobins, Abnormal; Humans; Kinetics; Lysine; Macromolecular Substances; Oxyhemoglobins; Solubility; Structure-Activity Relationship; Valine | 1987 |
Quinolinate is a weak excitant of cortical neurons in cell culture.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Magnesium; Membrane Potentials; Mice; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Cyanides; Glutamates; Glutamic Acid; L-Lactate Dehydrogenase; Mice; Neurons; Oxygen; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1987 |
Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Oxadiazoles; Quisqualic Acid; Valine | 1988 |
Synaptic transmission between rat cerebellar granule and Purkinje cells in dissociated cell culture: effects of excitatory-amino acid transmitter antagonists.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Aspartic Acid; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Purkinje Cells; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission; Tetrodotoxin; Valine | 1988 |
Mode of binding of [3H]dibenzocycloalkenimine (MK-801) to the N-methyl-D-aspartate (NMDA) receptor and its therapeutic implication.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Kinetics; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antibody Specificity; Aspartic Acid; Binding Sites; Factor VIII; Glutamates; Glutamic Acid; Isoleucine; Valine; von Willebrand Factor | 1988 |
Changes in the state of the excitatory synaptic system in the hippocampus on prolonged exposure to excitatory amino acids and antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Action Potentials; Animals; Aspartic Acid; Dipeptides; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Valine | 1988 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
Evidence of N-methyl-D-aspartate receptor-mediated modulation of the aortic baroreceptor reflex in the rat nucleus tractus solitarii.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aorta; Blood Pressure; Glutamates; Glutamic Acid; Heart Rate; Kainic Acid; Male; Medulla Oblongata; Oxadiazoles; Pressoreceptors; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Tetrodotoxin; Valine | 1988 |
Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.
Topics: Animals; Cells, Cultured; Chromosome Deletion; ErbB Receptors; Gene Expression Regulation; Glutamates; Glutamic Acid; Mice; Mutation; Oncogenes; Plasmids; Protein-Tyrosine Kinases; Receptors, Cell Surface; Transfection; Valine | 1988 |
[3H]D-2-amino-5-phosphonopentanoate as a ligand for N-methyl-D-aspartate receptors in the mammalian central nervous system.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Subcellular Fractions; Temperature; Valine | 1988 |
An intracellular analysis of amino acid induced excitations of deep dorsal horn neurones in the rat spinal cord slice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Rats; Spinal Cord; Tetrodotoxin; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Behavioral classification of excitatory amino acid receptors in mouse spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Behavior, Animal; Glutamates; Glutamic Acid; Glutamine; Kainic Acid; Male; Mice; Mice, Inbred ICR; N-Methylaspartate; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Spinal Cord; Valine | 1988 |
Glutamate induces a depolarization of adult rat dorsal root ganglion neurons that is mediated predominantly by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Ganglia, Spinal; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Magnesium; Neurons; Oxadiazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Assessment of effects of amino acids and branched chain keto acids on leucine oxidation in human lymphocytes.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adolescent; Adult; Alanine; Amino Acids; Female; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Isoleucine; Keto Acids; Ketone Oxidoreductases; Leucine; Lymphocytes; Male; Middle Aged; Multienzyme Complexes; Oxidation-Reduction; Valine | 1988 |
Evidence for multiple differing cation binding sites on hemoglobin A and S.
Topics: Binding Sites; Cations, Divalent; Circular Dichroism; Glutamates; Glutamic Acid; Hemoglobin A; Hemoglobin, Sickle; Humans; Oxygen Consumption; Protein Conformation; Valine | 1981 |
Phosphonate analogues of carboxylic acids as aminoacid antagonists on rat cortical neurones.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Drug Antagonism; Electric Conductivity; Glutamates; Glutamic Acid; Isomerism; Kainic Acid; N-Methylaspartate; Neurons; Organophosphorus Compounds; Rats; Valine | 1981 |
Aspartate may be an excitatory transmitter mediating visual excitation of "sustained" but not "transient" cells in the cat retina: iontophoretic studies in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cats; Dipeptides; Glutamates; Glutamic Acid; Neurons; Neurotransmitter Agents; Retina; Synaptic Transmission; Valine | 1982 |
Glutamic acid agonists. Stereochemical and conformational studies of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and related compounds.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Evoked Potentials; Ganglia, Spinal; Glutamates; Glutamic Acid; Ibotenic Acid; Interneurons; Oxazoles; Spinal Cord; Stereoisomerism; Synaptic Transmission; Valine | 1982 |
Characterization of the excitatory amino acid receptor-mediated release of [3H]acetylcholine from rat striatal slices.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Afferent Pathways; Animals; Aspartic Acid; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Interneurons; Magnesium; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine | 1982 |
Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cats; Dipeptides; Female; Glutamates; Glutamic Acid; Male; Pipecolic Acids; Receptors, Neurotransmitter; Spinal Cord; Synaptic Transmission; Valine | 1983 |
Relative deficiencies of amino acids and nitrogen per se in low protein diets for young turkeys.
Topics: Amino Acids; Animals; Body Weight; Dietary Proteins; Female; Glutamates; Glutamic Acid; Lysine; Male; Nitrogen; Threonine; Turkeys; Valine | 1983 |
[Compartmentalization of metabolism of spatially-delimiting amino acid pools of yeast cells].
Topics: Alanine; Amino Acids; Aspartic Acid; Candida; Cell Compartmentation; Cytoplasm; Glutamates; Glutamic Acid; Kinetics; Mitochondria; Organoids; Structure-Activity Relationship; Vacuoles; Valine | 1983 |
Adrenergic inhibition of branched-chain 2-oxo acid dehydrogenase in rat diaphragm muscle in vitro.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Aspartic Acid; Bucladesine; Epinephrine; Glutamates; Glutamic Acid; In Vitro Techniques; Ketone Oxidoreductases; Male; Multienzyme Complexes; Muscles; Oxidation-Reduction; Phenylephrine; Rats; Rats, Inbred Strains; Valine | 1983 |
Accumulation of putative amino acid neurotransmitters, monoamines and D-Ala2-Met-enkephalinamide in primary astroglial cultures from various brain areas, visualized by autoradiography.
Topics: Amino Acids; Animals; Aspartic Acid; Astrocytes; Autoradiography; Brain; Culture Techniques; Dopamine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Valine | 1983 |
Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Culture Techniques; Electric Conductivity; Glutamates; Glutamic Acid; Homocysteine; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Spinal Cord; Valine | 1984 |
The actions of 'selective' excitatory amino acid antagonists on the crustacean neuromuscular junction.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Anomura; Dipeptides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Neuromuscular Junction; Norleucine; Pyridines; Synaptic Transmission; Valine | 1984 |
Hemoglobin Hofu: beta 126 (H4) valine----glutamic acid observed in a Japanese family.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Female; Glutamates; Glutamic Acid; Hemoglobins, Abnormal; Humans; Japan; Middle Aged; Valine | 1984 |
Inhibition of glutamate uptake with L-trans-pyrrolidine-2,4-dicarboxylate potentiates glutamate toxicity in primary hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cells, Cultured; Dicarboxylic Acids; Drug Synergism; Embryo, Mammalian; Female; Glutamates; Glutamic Acid; Hippocampus; Kinetics; Macrophages; Neuroglia; Neurons; Neurotoxins; Pregnancy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1993 |
Activation of K+ channels by stimulation of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Glutamic Acid; Hippocampus; In Vitro Techniques; Neurons; Potassium Channels; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Valine | 1995 |
Leucine affects the metabolism of valine by isolated perfused rat hearts: relation to branched-chain amino acid antagonism.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Alanine; Amino Acids, Branched-Chain; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; Ketone Oxidoreductases; Leucine; Male; Multienzyme Complexes; Myocardium; Phenylalanine; Rats; Rats, Sprague-Dawley; Time Factors; Transaminases; Valine | 1995 |
Binding of high-molecular-mass kininogen to the Apple 1 domain of factor XI is mediated in part by Val64 and Ile77.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Computer Simulation; Factor XI; Glutamic Acid; Humans; Isoleucine; Kininogens; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Binding; Protein Conformation; Recombinant Proteins; Serine; Valine | 1994 |
N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; Female; Gestational Age; Glutamates; Glutamic Acid; Glycine; Kinetics; Kynurenic Acid; N-Methylaspartate; Pregnancy; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Rhombencephalon; Serotonin; Strychnine; Valine | 1993 |
Participation of aspartic acid and pyrroloquinoline quinone in vitamin B12 production in Klebsiella pneumoniae IFO 13541.
Topics: Alanine; Amino Acids; Aspartic Acid; Culture Media; Glutamates; Glutamic Acid; Klebsiella pneumoniae; Oxidoreductases; PQQ Cofactor; Quinolones; Valine; Vitamin B 12 | 1993 |
Role of alpha and beta carboxyl-terminal residues in the kinetics of human oxyhemoglobin dimer assembly.
Topics: Amino Acid Sequence; Arginine; Genetic Variation; Glutamates; Glutamic Acid; Heme; Hemoglobin A; Hemoglobins, Abnormal; Histidine; Humans; Hydrogen-Ion Concentration; Kinetics; Macromolecular Substances; Oxyhemoglobins; Point Mutation; Spectrophotometry; Tyrosine; Valine | 1994 |
A compound heterozygote for lipoprotein lipase deficiency, Val69-->Leu and Gly188-->Glu: correlation between in vitro LPL activity and clinical expression.
Topics: Adult; Base Sequence; Blotting, Southern; DNA; Glutamates; Glutamic Acid; Glycine; Heterozygote; Humans; Leucine; Lipoprotein Lipase; Male; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Valine | 1994 |
High-resolution 1H-magnetic resonance spectroscopy of pediatric posterior fossa tumors in vitro.
Topics: Adolescent; Alanine; Amino Acids; Animals; Aspartic Acid; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Child; Child, Preschool; Choline; Cranial Fossa, Posterior; Glutamates; Glutamic Acid; Humans; In Vitro Techniques; Infant; Magnetic Resonance Spectroscopy; Medulloblastoma; Neuroectodermal Tumors; Neurotransmitter Agents; Rats; Valine | 1994 |
Hb Trollhättan [beta 20(B2)Val-->Glu]--a new haemoglobin variant with increased oxygen affinity causing erythrocytosis.
Topics: Adult; Amino Acid Sequence; Base Sequence; Codon; DNA; Globins; Glutamates; Glutamic Acid; Haplotypes; Hemoglobins, Abnormal; Humans; Male; Molecular Sequence Data; Mutation; Oxygen; Polycythemia; Sweden; Valine | 1994 |
Dietary pectin's effect on ileal and fecal amino acid digestibility and exocrine pancreatic secretions in growing pigs.
Topics: alpha-Amylases; Amino Acids; Animals; Aspartic Acid; Dietary Fiber; Digestion; Feces; Glutamates; Glutamic Acid; Glycine; Ileum; Male; Pancreas; Pancreatic Juice; Pectins; Phenylalanine; Proline; Serine; Swine; Threonine; Trypsin; Valine | 1994 |
Molecular mechanism for familial protein C deficiency and thrombosis in protein CVermont (Glu20-->Ala and Val34-->Met).
Topics: Alanine; Base Sequence; DNA Primers; Glutamic Acid; Humans; Methionine; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein C; Protein C Deficiency; Thrombosis; Valine | 1994 |
An assessment of progression of brain edema with amino acid levels in cerebrospinal fluid and changes in electroencephalogram in an adult cat model of cold brain injury.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cats; Electroencephalography; Evoked Potentials; Freezing; Glutamic Acid; Methionine; Motor Cortex; Phenylalanine; Serine; Synaptic Transmission; Tyrosine; Valine | 1994 |
A new variant Cu/Zn superoxide dismutase (Val7-->Glu) deduced from lymphocyte mRNA sequences from Japanese patients with familial amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Base Sequence; DNA Primers; Female; Glutamic Acid; Humans; Japan; Lymphocytes; Male; Middle Aged; Molecular Sequence Data; Mutation; RNA, Messenger; Superoxide Dismutase; Valine | 1994 |
Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity.
Topics: Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Phenylalanine; Recombinant Proteins; Substrate Specificity; Valine | 1994 |
Structural and functional organization of the surfactin synthetase multienzyme system.
Topics: Aspartic Acid; Bacillus subtilis; Bacterial Proteins; Centrifugation, Density Gradient; Chromatography, Gel; Chromatography, Ion Exchange; Glutamates; Glutamic Acid; Kinetics; Leucine; Macromolecular Substances; Multienzyme Complexes; Peptide Synthases; Substrate Specificity; Valine | 1993 |
Neuroendocrine control of osmotic regulation in the freshwater shrimp Macrobrachium olfersii (Wiegmann) (Crustacea, decapoda): free amino acid concentrations in the hemolymph.
Topics: Alanine; Amino Acids; Animals; Female; Glutamic Acid; Hemolymph; Leucine; Neurosecretory Systems; Optic Nerve; Palaemonidae; Thoracic Nerves; Valine; Water-Electrolyte Balance | 1995 |
Glu-416 of beta-galactosidase (Escherichia coli) is a Mg2+ ligand and beta-galactosidases with substitutions for Glu-416 are inactivated, rather than activated, by MG2+.
Topics: Amino Acid Sequence; beta-Galactosidase; Binding Sites; Escherichia coli; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Kinetics; Ligands; Magnesium; Mutagenesis, Site-Directed; Recombinant Proteins; Valine | 1996 |
Functional studies and polymerization of recombinant hemoglobin Glu-alpha2beta26(A3) --> Val/Glu-7(A4) --> Ala.
Topics: Alanine; Computer Graphics; Globins; Glutamic Acid; Hemoglobin A; Hemoglobin, Sickle; Hemoglobins; Humans; Isoelectric Focusing; Kinetics; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Oxyhemoglobins; Point Mutation; Protein Conformation; Valine | 1996 |
Point mutations characterize KEL10, the KEL3, KEL4, and KEL21 alleles, and the KEL17 and KEL11 alleles.
Topics: Alanine; Alleles; Amino Acid Sequence; Arginine; Base Sequence; Codon; DNA; Exons; Glutamic Acid; Glutamine; Humans; Kell Blood-Group System; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Tryptophan; Valine | 1996 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine | 1996 |
Functional site in alpha-lactalbumin encompasses a region corresponding to a subsite in lysozyme and parts of two adjacent flexible substructures.
Topics: Amino Acid Sequence; Conserved Sequence; DNA Primers; Glutamic Acid; Glutamine; Histidine; Isoleucine; Kinetics; Lactalbumin; Leucine; Models, Molecular; Muramidase; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Protein Conformation; Protein Structure, Secondary; Valine | 1996 |
A large compressibility change of protein induced by a single amino acid substitution.
Topics: Aspartate Aminotransferases; Aspartic Acid; Escherichia coli; Glutamic Acid; Glycine; Linear Models; NADP; Phenylalanine; Point Mutation; Proteins; Pyridoxal Phosphate; Tetrahydrofolate Dehydrogenase; Valine | 1996 |
Site-directed mutagenesis of the amino acid residues in beta-strand III [Val30-Val36] of D-amino acid aminotransferase of Bacillus sp. YM-1.
Topics: Alanine Transaminase; Bacillus; Binding Sites; D-Alanine Transaminase; Glutamic Acid; Hemiterpenes; Hydrogen Bonding; Hydrogen-Ion Concentration; Keto Acids; Ketoglutaric Acids; Kinetics; Lysine; Mutagenesis, Site-Directed; Pyridoxal Phosphate; Spectrometry, Fluorescence; Valine | 1996 |
Biosynthesis of 'essential' amino acids by scleractinian corals.
Topics: Amino Acids, Essential; Animals; Carbon Radioisotopes; Cnidaria; Glucose; Glutamic Acid; Lysine; Valine | 1997 |
Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral.
Topics: Animals; Cell Cycle Proteins; Cell Line; COS Cells; Genes, fos; Glutamic Acid; Glycine; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Mutagenesis, Site-Directed; Phosphoprotein Phosphatases; Point Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; ras Proteins; ras-GRF1; Recombinant Fusion Proteins; Sequence Deletion; Signal Transduction; Spodoptera; Transfection; Valine | 1997 |
Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Channels; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ion Channel Gating; Lysophospholipids; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, Glutamate; Valine | 1997 |
Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly.
Topics: Alanine; Amino Acid Sequence; Animals; Cell Line, Transformed; DNA Mutational Analysis; Exons; Female; Genes, Dominant; Glutamic Acid; Glycine; Hedgehog Proteins; Holoprosencephaly; Humans; Male; Molecular Sequence Data; Pedigree; Point Mutation; Proteins; Sequence Deletion; Sequence Homology, Amino Acid; Serine; Threonine; Trans-Activators; Valine | 1997 |
Activation of a retroviral membrane fusion protein: soluble receptor-induced liposome binding of the ALSV envelope glycoprotein.
Topics: 3T3 Cells; Amino Acid Substitution; Animals; Avian Proteins; Binding Sites; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Liposomes; Membrane Fusion; Mice; Mutagenesis, Site-Directed; Receptors, Virus; Recombinant Fusion Proteins; Thermodynamics; Transfection; Valine; Viral Envelope Proteins | 1997 |
Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1.
Topics: Adjuvants, Immunologic; Animals; Carrier Proteins; Chromatography, Affinity; Enzyme Induction; Glutamic Acid; Heme Oxygenase (Decyclizing); HLA-B Antigens; Immunosuppressive Agents; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mutation; Peptide Fragments; Protoporphyrins; Valine | 1998 |
Calcium binding to the first EGF-like module of human factor IX in a recombinant fragment containing residues 1-85. Mutations V46E and Q50E each manifest a negligible increase in calcium affinity.
Topics: Amino Acid Sequence; Animals; Calcium; Cell Line; Epidermal Growth Factor; Factor IX; Glutamic Acid; Glutamine; Humans; Molecular Sequence Data; Mutation; Recombinant Fusion Proteins; Spodoptera; Valine | 1998 |
Influence of polymorphism Q3405E and mutation A3371V in the apolipoprotein B gene on LDL receptor binding.
Topics: Adult; Aged; Alanine; Amino Acid Substitution; Apolipoproteins B; DNA; DNA Mutational Analysis; Family; Family Health; Female; Gene Frequency; Glutamic Acid; Glutamine; Haplotypes; Humans; Hyperlipidemias; Leucine; Lipoproteins, LDL; Male; Middle Aged; Point Mutation; Polymorphism, Genetic; Protein Binding; Receptors, LDL; Valine | 1998 |
Kinetic characterization of myosin head fragments with long-lived myosin.ATP states.
Topics: Actins; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Dictyostelium; Glutamic Acid; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Myosins; ortho-Aminobenzoates; Protein Binding; Spectrometry, Fluorescence; Valine | 1998 |
Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation.
Topics: Amino Acid Sequence; Animals; Computer Simulation; Connectin; Glutamic Acid; Immunoglobulins; Lysine; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Muscle Proteins; Myocardium; Proline; Protein Denaturation; Protein Folding; Protein Kinases; Protein Structure, Secondary; Sequence Alignment; Sequence Homology, Amino Acid; Valine | 1998 |
PEVK extension of human soleus muscle titin revealed by immunolabeling with the anti-titin antibody 9D10.
Topics: Animals; Antibodies; Cells, Cultured; Connectin; Glutamic Acid; Humans; Immunoglobulins; Lysine; Microscopy, Immunoelectron; Muscle Proteins; Muscle, Skeletal; Myocardium; Peptide Fragments; Proline; Protein Kinases; Rats; Sarcomeres; Valine | 1998 |
A survey of the primary structure and the interspecies conservation of I-band titin's elastic elements in vertebrates.
Topics: Amino Acid Sequence; Animals; Connectin; Conserved Sequence; Glutamic Acid; Humans; Lysine; Molecular Sequence Data; Muscle Proteins; Proline; Protein Kinases; Sequence Alignment; Species Specificity; Valine | 1998 |
Polymorphisms of the beta chain of the high-affinity immunoglobulin E receptor (Fcepsilon RI-beta) in South African black and white asthmatic and nonasthmatic individuals.
Topics: Adolescent; Adult; Asthma; Black People; Chi-Square Distribution; Child; Exons; Female; Gene Frequency; Glutamic Acid; Glycine; Humans; Hypersensitivity, Immediate; Immunoglobulin E; Isoleucine; Leucine; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Prevalence; Receptors, IgE; South Africa; Valine; White People | 1998 |
Role of active-site residues 107 and 108 of glutathione S-transferase mGSTA4-4 in determining the catalytic properties of the enzyme for 4-hydroxynonenal.
Topics: Alanine; Aldehydes; Amino Acid Substitution; Animals; Binding Sites; Catalysis; Enzyme Stability; Glutamic Acid; Glutathione Transferase; Hot Temperature; Kinetics; Leucine; Methionine; Mice; Models, Molecular; Mutagenesis, Site-Directed; Recombinant Proteins; Valine | 1999 |
Role of the buried glutamate in the alpha-helical coiled coil domain of the macrophage scavenger receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Aspartic Acid; Cattle; Glutamic Acid; Glutamine; Histidine; Humans; Hydrogen-Ion Concentration; Macrophages; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Conformation; Protein Structure, Secondary; Rabbits; Receptors, Immunologic; Receptors, Scavenger; Sequence Analysis; Valine | 1999 |
Interaction site for high-potential iron-sulfur protein on the tetraheme cytochrome subunit bound to the photosynthetic reaction center of Rubrivivax gelatinosus.
Topics: Bacterial Proteins; Binding Sites; Cytochromes; Electron Transport; Glutamic Acid; Heme; Iron-Sulfur Proteins; Light-Harvesting Protein Complexes; Lysine; Macromolecular Substances; Models, Molecular; Mutagenesis, Site-Directed; Photosynthetic Reaction Center Complex Proteins; Rhodospirillaceae; Valine | 1999 |
Raman markers of nonaromatic side chains in an alpha-helix assembly: Ala, Asp, Glu, Gly, Ile, Leu, Lys, Ser, and Val residues of phage fd subunits.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Deuterium; DNA, Single-Stranded; Glutamic Acid; Glycine; Inovirus; Isoleucine; Lysine; Molecular Sequence Data; Protein Structure, Secondary; Serine; Spectrum Analysis, Raman; Valine; Viral Proteins; Virus Assembly | 1999 |
Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del. Mutations in brief no. 142. Online.
Topics: Adenosine Deaminase; Adolescent; Adult; Age of Onset; Arginine; Cysteine; Glutamic Acid; Glutamine; Glycine; Humans; Methionine; Mutation; Proline; Sequence Deletion; Severe Combined Immunodeficiency; Tryptophan; Valine | 1998 |
Proton NMR investigation of the heme active site structure of an engineered cytochrome c peroxidase that mimics manganese peroxidase.
Topics: Arginine; Aspartic Acid; Binding Sites; Cyanides; Cytochrome-c Peroxidase; Glutamic Acid; Glycine; Heme; Histidine; Leucine; Molecular Mimicry; Nuclear Magnetic Resonance, Biomolecular; Peroxidases; Protein Engineering; Protons; Spectrophotometry; Valine | 1999 |
Effects of lesions to the glutamatergic afferents to the nucleus accumbens in the modulation of reactivity to spatial and non-spatial novelty in mice.
Topics: Afferent Pathways; Amygdala; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Hippocampus; Ibotenic Acid; Injections; Limbic System; Mice; Models, Neurological; Motor Activity; N-Methylaspartate; Nucleus Accumbens; Spatial Behavior; Valine | 1999 |
Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF, or to different constitutively active mutants of the GM-CSF receptor beta subunit.
Topics: Amino Acid Substitution; Animals; Asparagine; Cell Differentiation; Cell Line; Cell Line, Transformed; Glutamic Acid; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Interleukin-3; Isoleucine; Macromolecular Substances; Mice; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Receptors, Interleukin-3; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Valine | 2000 |
Identification of three novel mutations (E196K, V203I, E211Q) in the prion protein gene (PRNP) in inherited prion diseases with Creutzfeldt-Jakob disease phenotype.
Topics: Aged; Amino Acid Substitution; Amyloid; Creutzfeldt-Jakob Syndrome; Female; Glutamic Acid; Glutamine; Humans; Isoleucine; Lysine; Male; Middle Aged; Mutation, Missense; Phenotype; Prion Proteins; Prions; Protein Precursors; Valine | 2000 |
Laminar characteristics of functional connectivity in rat barrel cortex revealed by stimulation with caged-glutamate.
Topics: Animals; Brain Mapping; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Neural Pathways; Neurons; Photic Stimulation; Photolysis; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Somatosensory Cortex; Synapses; Time Factors; Valine; Vibrissae | 2000 |
Relocation of internal bound water in bacteriorhodopsin during the photoreaction of M at low temperatures: an FTIR study.
Topics: Aspartic Acid; Bacteriorhodopsins; Cell Polarity; Glutamic Acid; Halobacterium; Mutation; Proton Pumps; Retinaldehyde; Schiff Bases; Spectroscopy, Fourier Transform Infrared; Threonine; Valine; Water | 2000 |
High apparent dielectric constants in the interior of a protein reflect water penetration.
Topics: Amino Acid Substitution; Computer Simulation; Crystallography, X-Ray; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Micrococcal Nuclease; Models, Molecular; Mutagenesis, Site-Directed; Potentiometry; Protein Denaturation; Protein Structure, Secondary; Recombinant Proteins; Thermodynamics; Valine | 2000 |
Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions.
Topics: Basophils; Cell Line; Cell Membrane; Gene Amplification; Genetic Variation; Glutamic Acid; Glycine; Humans; Hypersensitivity, Immediate; Intracellular Fluid; Isoleucine; Leucine; Polymorphism, Genetic; Protein Processing, Post-Translational; Receptors, IgE; Transfection; U937 Cells; Valine | 2000 |
Redesigning the substrate specificity of an enzyme: isocitrate dehydrogenase.
Topics: 3-Isopropylmalate Dehydrogenase; Alcohol Oxidoreductases; Amino Acid Sequence; Amino Acid Substitution; Asparagine; Enzyme Activation; Escherichia coli; Glutamic Acid; Helix-Loop-Helix Motifs; Isocitrate Dehydrogenase; Isocitrates; Malates; Molecular Sequence Data; Mutagenesis, Insertional; Mutagenesis, Site-Directed; Protein Engineering; Protein Structure, Secondary; Recombinant Fusion Proteins; Serine; Substrate Specificity; Thermus thermophilus; Thiobacillus; Valine | 2000 |
Substitution of Glu-59 by Val in amidase from Pseudomonas aeruginosa results in a catalytically inactive enzyme.
Topics: Amidohydrolases; Amino Acid Substitution; Catalysis; Chromatography, Affinity; Chromatography, Gel; Cloning, Molecular; DNA Primers; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Amplification; Glutamic Acid; Kinetics; Molecular Weight; Polymerase Chain Reaction; Pseudomonas aeruginosa; Recombinant Proteins; Valine | 2000 |
Inhibition of glutamate uptake into synaptic vesicles of rat brain by the metabolites accumulating in maple syrup urine disease.
Topics: Animals; Brain; Glutamic Acid; Hemiterpenes; Isoleucine; Keto Acids; Leucine; Male; Maple Syrup Urine Disease; Neurons; Rats; Rats, Wistar; Synaptic Vesicles; Synaptosomes; Valine | 2000 |
Interactions between yeast iso-1-cytochrome c and its peroxidase.
Topics: Alanine; Amino Acid Substitution; Aspartic Acid; Binding Sites; Calorimetry; Crystallography, X-Ray; Cytochrome c Group; Cytochrome-c Peroxidase; Cytochromes c; Glutamic Acid; Lysine; Macromolecular Substances; Mutagenesis, Site-Directed; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Solutions; Thermodynamics; Valine | 2001 |
Engineering conformational flexibility in the lactose permease of Escherichia coli: use of glycine-scanning mutagenesis to rescue mutant Glu325-->Asp.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aspartic Acid; Biological Transport, Active; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Glutamic Acid; Glycine; Kinetics; Membrane Transport Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Symporters; Valine | 2001 |
Prevalence and conditions of selection of E44D/A and V118I human immunodeficiency virus type 1 reverse transcriptase mutations in clinical practice.
Topics: Alanine; Amino Acid Substitution; Anti-HIV Agents; Aspartic Acid; Drug Resistance, Microbial; Gene Frequency; Glutamic Acid; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Isoleucine; Mutation; Valine | 2001 |
The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds.
Topics: Amino Acid Sequence; Binding Sites; Calcium-Binding Proteins; Cell Line; Cysteine; Dimerization; Disulfides; Dose-Response Relationship, Drug; Endopeptidases; Glutamic Acid; Humans; Immunoblotting; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation; Protein Sorting Signals; Protein Structure, Tertiary; Transfection; Valine | 2001 |
Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells.
Topics: Allosteric Regulation; Amino Acids, Cyclic; Cell Line; Decarboxylation; Enzyme Activation; Glutamate Dehydrogenase; Glutamic Acid; Islets of Langerhans; Isoleucine; Leucine; Mitochondria; Models, Biological; Oxidation-Reduction; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Biosynthesis; Protein Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Valine | 2001 |
Modeling and experimental design for metabolic flux analysis of lysine-producing Corynebacteria by mass spectrometry.
Topics: Computer Simulation; Corynebacterium; Glucose-6-Phosphate Isomerase; Glutamic Acid; Glycolysis; Lysine; Mass Spectrometry; Models, Biological; Models, Theoretical; Phenylalanine; Pyruvic Acid; Riboflavin; Transaldolase; Transketolase; Valine | 2001 |
Derivatization and fluorescence detection of amino acids and peptides with 9-fluorenylmethyl chloroformate on the surface of a solid adsorbent.
Topics: Amino Acids; Chromatography; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Fluorenes; gamma-Aminobutyric Acid; Glutamic Acid; Indicators and Reagents; Lysine; Peptides; Phenylalanine; Reproducibility of Results; Serine; Spectrometry, Fluorescence; Substance P; Valine | 2001 |
Stress-induced increase in extracellular dopamine in striatum: role of glutamatergic action via N-methyl-D-aspartate receptors in substantia nigra.
Topics: Animals; Dopamine; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Hydrazines; Male; Microdialysis; Neostriatum; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Substantia Nigra; Valine | 2001 |
MAP2 phosphorylation and visual plasticity in Xenopus.
Topics: Aging; Animals; Dendrites; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Agonists; Glutamic Acid; Immunoblotting; Microtubule-Associated Proteins; N-Methylaspartate; Neuronal Plasticity; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Superior Colliculi; Valine; Vision, Binocular; Visual Pathways; Xenopus laevis | 2001 |
Membrane interactions of mutated forms of the influenza fusion peptide.
Topics: Alanine; Amino Acid Sequence; Deuterium; Glutamic Acid; Glycine; Hemagglutinin Glycoproteins, Influenza Virus; Kinetics; Lipid Bilayers; Membrane Fusion; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Phosphorus Isotopes; Protein Conformation; Protein Structure, Secondary; Serine; Spectroscopy, Fourier Transform Infrared; Valine; Viral Fusion Proteins | 2001 |
Capture of a dimeric intermediate during transthyretin amyloid formation.
Topics: Amyloid; Amyloid Neuropathies, Familial; Anilino Naphthalenesulfonates; Asparagine; Dimerization; Fluorescent Dyes; Glutamic Acid; Guanidine; Humans; Models, Molecular; Mutation; Prealbumin; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Recombinant Proteins; Staining and Labeling; Temperature; Thyroxine; Valine | 2001 |
Nitrogen source governs the patterns of growth and pristinamycin production in 'Streptomyces pristinaespiralis'.
Topics: Alanine; Ammonium Chloride; Anti-Bacterial Agents; Glucose; Glutamic Acid; Kinetics; Models, Biological; Nitrates; Nitrogen; Pristinamycin; Streptomyces; Valine | 2001 |
Purification of anthrax edema factor from Escherichia coli and identification of residues required for binding to anthrax protective antigen.
Topics: Adenylyl Cyclases; Animals; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Escherichia coli; Exotoxins; Gene Expression; Glutamic Acid; Glycine; Isoleucine; Lysine; Receptors, Peptide; Recombinant Fusion Proteins; Tyrosine; Valine | 2001 |
Establishment of CHO cell lines expressing four N-methyl-D-aspartate receptor subtypes and characterization of a novel antagonist PPDC.
Topics: Animals; Calcium; CHO Cells; Cricetinae; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Glycine; Hot Temperature; Piperidines; Protein Isoforms; Receptors, N-Methyl-D-Aspartate; Valine | 2001 |
Glu375Gln and Asp225Val mutants: about the nature of the covalent linkages between heme group and apo-Protein in bovine lactoperoxidase.
Topics: Amino Acid Substitution; Animals; Aspartic Acid; Base Sequence; Blotting, Western; Cattle; CHO Cells; Cricetinae; DNA Primers; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Glycine; Heme; Lactoperoxidase; Mutation; Valine | 2001 |
Survivability of biomolecules during extraterrestrial delivery: new results on pyrolysis of amino acids and poly-amino acids.
Topics: Amino Acids; beta-Alanine; Extraterrestrial Environment; Gels; Glutamic Acid; Hot Temperature; Leucine; Meteoroids; Phenylalanine; Piperazines; Proline; Pyrrolidonecarboxylic Acid; Silica Gel; Silicon Dioxide; Valine | 2001 |
Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat.
Topics: Afferent Pathways; Animals; Cell Count; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; Inflammation; Male; Muscle, Skeletal; Nociceptors; Pain; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Skin; Synaptic Transmission; Turpentine; Valine | 2001 |
NMDA and muscarinic blockade in the perirhinal cortex impairs object discrimination in rats.
Topics: Acetylcholine; Animals; Discrimination Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memory, Short-Term; Muscarinic Antagonists; Neurons; Parahippocampal Gyrus; Pattern Recognition, Visual; Photic Stimulation; Rats; Rats, Long-Evans; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Scopolamine; Synaptic Transmission; Valine | 2001 |
Structural implications of a Val-->Glu mutation in transmembrane peptides from the EGF receptor.
Topics: Amino Acid Motifs; Amino Acid Sequence; Cell Membrane; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; Genes, erbB-2; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides; Phenotype; Protein Structure, Tertiary; Receptor, ErbB-2; Valine | 2001 |
Tn5 transposase with an altered specificity for transposon ends.
Topics: Directed Molecular Evolution; DNA Transposable Elements; Glutamic Acid; Models, Molecular; Point Mutation; Recombination, Genetic; Repetitive Sequences, Nucleic Acid; Selection, Genetic; Substrate Specificity; Transposases; Valine | 2002 |
The single transmembrane domains of ErbB receptors self-associate in cell membranes.
Topics: Amino Acid Motifs; Amino Acid Sequence; Cell Membrane; Chloramphenicol O-Acetyltransferase; Dimerization; DNA Mutational Analysis; ErbB Receptors; Escherichia coli; Genetic Vectors; Glutamic Acid; Humans; Ligands; Maltose; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Valine | 2002 |
N-terminal contributions of the gamma-subunit of fetal hemoglobin to its tetramer strength: remote effects at subunit contacts.
Topics: Amino Acid Sequence; Aspartic Acid; Circular Dichroism; Dimerization; Dose-Response Relationship, Drug; Fetal Hemoglobin; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Isoelectric Focusing; Isoleucine; Kinetics; Leucine; Mass Spectrometry; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxygen; Phenylalanine; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Valine | 2002 |
Synergistic enhancement of glutamate-mediated responses by serotonin and forskolin in adult mouse spinal dorsal horn neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenylyl Cyclases; Animals; Colforsin; Drug Synergism; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Posterior Horn Cells; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Valine | 2002 |
Inhibitory effects of angiotensin II on barosensitive rostral ventrolateral medulla neurons of the rat.
Topics: Adrenergic alpha-Agonists; Anesthesia; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Glutamic Acid; Imidazoles; Medulla Oblongata; Neurons; Phenylephrine; Pressoreceptors; Pyridines; Rats; Rats, Wistar; Tetrazoles; Time Factors; Valine; Valsartan; Vasoconstrictor Agents | 2001 |
Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association.
Topics: Amino Acid Motifs; Amino Acids; Animals; COS Cells; Dimerization; Glutamic Acid; Humans; K562 Cells; Ligands; Mutation; Phosphorylation; Precipitin Tests; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Receptor, ErbB-2; Time Factors; Transcriptional Activation; Transfection; Tyrosine; Valine | 2002 |
An essential amino acid residue for catalytic activity of the dextranase of Streptococcus mutans.
Topics: Amino Acid Sequence; Amino Acids, Essential; Asparagine; Aspartic Acid; Binding Sites; Dextranase; Glucosyltransferases; Glutamic Acid; Humans; Molecular Biology; Mutagenesis, Site-Directed; Sequence Analysis, Protein; Streptococcus; Streptococcus mutans; Streptococcus sobrinus; Threonine; Valine | 2002 |
Effect of a new injectable male contraceptive on the seminal plasma amino acids studied by proton NMR spectroscopy.
Topics: Adult; Alanine; Amino Acids; Arginine; Contraceptive Agents, Male; Dimethyl Sulfoxide; Glutamic Acid; Glutamine; Humans; Injections; Isoleucine; Leucine; Lysine; Magnetic Resonance Spectroscopy; Male; Maleates; Polyesters; Polystyrenes; Semen; Styrenes; Valine; Vas Deferens | 2002 |
Halide-stabilizing residues of haloalkane dehalogenases studied by quantum mechanic calculations and site-directed mutagenesis.
Topics: Amino Acids; Anions; Asparagine; Glutamic Acid; Halogens; Histidine; Hydrolases; Isoleucine; Leucine; Mathematical Computing; Models, Chemical; Mutagenesis, Site-Directed; Phenylalanine; Proline; Quantum Theory; Static Electricity; Tryptophan; Valine | 2002 |
The beta G156C substitution in the F1-ATPase from the thermophilic Bacillus PS3 affects catalytic site cooperativity by destabilizing the closed conformation of the catalytic site.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Bacillus; Binding Sites; Catalysis; Catalytic Domain; Cysteine; Dimethylamines; Enzyme Stability; Glutamic Acid; Glycine; Hydrolysis; Magnesium; Mutagenesis, Site-Directed; Protein Conformation; Proton-Translocating ATPases; Sodium Azide; Tryptophan; Tyrosine; Valine | 2002 |
Valine 114 replacements in archaeal elongation factor 1 alpha enhanced its ability to interact with aminoacyl-tRNA and kirromycin.
Topics: Alanine; Amino Acid Substitution; Archaeal Proteins; Glutamic Acid; GTP Phosphohydrolases; Hot Temperature; Lysine; Mutagenesis, Site-Directed; Peptide Elongation Factor 1; Protein Denaturation; Pyridones; RNA, Transfer, Amino Acid-Specific; Structure-Activity Relationship; Sulfolobus; Valine | 2002 |
Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Homovanillic Acid; Methamphetamine; Microdialysis; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors; Valine | 2003 |
Function of the loop residue Thr792 in human DNA topoisomerase II alpha.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Catalysis; Cell Division; Cysteine; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Fungal Proteins; Genetic Complementation Test; Glutamic Acid; Glycine; Humans; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Plasmids; Poly-ADP-Ribose Binding Proteins; Saccharomyces cerevisiae; Serine; Threonine; Valine | 2003 |
Distinctive cerebellar immunoreactivity for the prion protein in familial (E200K) Creutzfeldt-Jakob disease.
Topics: Cerebellum; Creutzfeldt-Jakob Syndrome; Genetic Variation; Glutamic Acid; Humans; Immunohistochemistry; Lysine; Methionine; Mutation; Prions; Valine | 2003 |
Amino acids Glu323, Tyr324, Glu330, and Val331 of factor Va heavy chain are essential for expression of cofactor activity.
Topics: Amino Acids; Animals; Anisotropy; Binding Sites; Blotting, Western; COS Cells; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Factor Va; Factor Xa; Glutamic Acid; Humans; Kinetics; Mutagenesis, Site-Directed; Mutation; Peptides; Protein Binding; Prothrombin; Recombinant Proteins; Spectrometry, Fluorescence; Thrombin; Thromboplastin; Time Factors; Transfection; Tyrosine; Valine | 2003 |
Breast and lung cancer are associated with a decrease in blood cell amino acid content.
Topics: Adult; Aged; Amino Acids; Amino Acids, Essential; Asparagine; Blood Cells; Breast Neoplasms; Female; Glutamic Acid; Humans; Lung Neoplasms; Male; Middle Aged; Ornithine; Plasma; Proline; Valine | 2003 |
Enhanced angiotensin-mediated responses in the nucleus tractus solitarii of spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Functional Laterality; Glutamic Acid; Heart Rate; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Solitary Nucleus; Species Specificity; Tetrazoles; Valine; Valsartan | 2003 |
Glutamate release in the nucleus accumbens is involved in behavioral depression during the PORSOLT swim test.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Male; Microdialysis; Microinjections; Motor Activity; Nucleus Accumbens; Physical Stimulation; Rats; Rats, Sprague-Dawley; Swimming; Tail; Time Factors; Valine | 2003 |
Malleable conformation of the elastic PEVK segment of titin: non-co-operative interconversion of polyproline II helix, beta-turn and unordered structures.
Topics: Amino Acid Motifs; Amino Acid Sequence; Circular Dichroism; Connectin; Elasticity; Glutamic Acid; Humans; Lysine; Molecular Sequence Data; Muscle Proteins; Nuclear Magnetic Resonance, Biomolecular; Osmolar Concentration; Peptides; Proline; Protein Conformation; Protein Kinases; Protein Structure, Secondary; Protein Structure, Tertiary; Salts; Stereoisomerism; Trifluoroethanol; Urea; Valine | 2003 |
Effect of mutations at Glu160 and Val198 on the thermostability of lactate oxidase.
Topics: Amino Acid Sequence; Amino Acid Substitution; Amino Acids; Enzyme Stability; Escherichia coli; Glutamic Acid; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Recombinant Proteins; Spinacia oleracea; Static Electricity; Temperature; Valine | 2003 |
In vitro reconstitution of signal transmission from a hair cell to the growth cone of a chick vestibular ganglion cell.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Calcium; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; Fura-2; Ganglia, Sensory; Glutamic Acid; Growth Cones; Hair Cells, Vestibular; Hippocampus; Immunohistochemistry; In Vitro Techniques; Neural Conduction; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Signal Transduction; Time Factors; Valine; Vestibule, Labyrinth | 2003 |
EFFECT OF CATIONS UPON HYDROPHOBICITY OF YEASTS GROWN IN AMINO ACID MEDIA.
Topics: Amino Acids; Ammonium Compounds; Cations; Chlorides; Culture Media; Glutamic Acid; Histidine; Hydrophobic and Hydrophilic Interactions; Lysine; Nitrogen; Phenylalanine; Proline; Quaternary Ammonium Compounds; Research; Tryptophan; Tyrosine; Valine; Yeasts | 1963 |
THE USE OF AMINO ACIDS AS STATIONARY PHASE IN GAS CHROMATOGRAPHY. 1. MONOSODIUM L-GLUTAMATE.
Topics: Alanine; Alcohols; Amino Acids; Chromatography; Chromatography, Gas; Fatty Acids; Glutamates; Glutamic Acid; Isoleucine; Leucine; Nitrogen; Research; Valine | 1964 |
ANTIGENICITY OF POLYPEPTIDES (POLY ALPHA AMINO ACIDS). XII. IMMUNOLOGICAL STUDIES WITH A NEW GROUP OF SYNTHETIC COPOLYMERS.
Topics: Alanine; Animals; Antibody Formation; Antigens; Glutamates; Glutamic Acid; Guinea Pigs; Immunoelectrophoresis; Lysine; Peptides; Polymers; Precipitin Tests; Rabbits; Research; Tyrosine; Valine | 1964 |
The N-terminal amino acids of human plasma proteins.
Topics: Alanine; Amino Acids; Aspartic Acid; Blood Proteins; Glutamic Acid; Glycine; Humans; Leucine; Nuclear Receptor Subfamily 4, Group A, Member 2; Tyrosine; Valine | 1962 |
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.
Topics: Animals; Astrocytes; Calcium; Calcium Signaling; Cell Line; Cells, Cultured; Coculture Techniques; Cycloleucine; Cytosol; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Epithelial Cells; Glutamic Acid; Green Fluorescent Proteins; Humans; Indomethacin; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Patch-Clamp Techniques; Prostaglandins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Transfection; Valine; Xanthones | 2003 |
Calcium-dependent molecular spring elements in the giant protein titin.
Topics: Amino Acid Motifs; Amino Acid Sequence; Calcium; Connectin; Exons; Gene Deletion; Glutamic Acid; Humans; Lysine; Molecular Sequence Data; Muscle Proteins; Muscles; Mutagenesis, Site-Directed; Proline; Protein Conformation; Protein Kinases; Recombinant Proteins; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Valine | 2003 |
Dose-response relationships for valine in the growing White Pekin duck.
Topics: Amino Acids; Animals; Diet; Dietary Proteins; Dietary Supplements; Dose-Response Relationship, Drug; Ducks; Energy Intake; Glutamic Acid; Male; Nitrogen; Proteins; Valine; Weight Gain | 2003 |
Characterization and functional analysis of the p42Ets-1 variant of the mouse Ets-1 transcription factor.
Topics: Alternative Splicing; Amino Acid Substitution; Animals; Base Sequence; Binding Sites; DNA Primers; DNA, Neoplasm; Exons; Genetic Variation; Genetic Vectors; Glutamic Acid; Mice; Molecular Sequence Data; Polymerase Chain Reaction; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Valine | 2003 |
Central administration of leucine, but not isoleucine and valine, stimulates feeding behavior in neonatal chicks.
Topics: Animals; Animals, Newborn; Appetite Regulation; Brain; Chickens; Feeding Behavior; Glutamic Acid; Hyperphagia; Isoleucine; Keto Acids; Leucine; Male; Reaction Time; Valine | 2004 |
Involvement of endogeneous glutamate in the stimulatory effect of norepinephrine and serotonin on the hypothalamo-pituitary-adrenocortical axis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Norepinephrine; Paraventricular Hypothalamic Nucleus; Phenylephrine; Pituitary-Adrenal System; Quinoxalines; Radioimmunoassay; Rats; Serotonin; Serotonin Receptor Agonists; Valine | 2004 |
Resonance Raman spectroscopy reveals the origin of an intermediate wavelength form in photoactive yellow protein.
Topics: Alanine; Amino Acid Substitution; Bacterial Proteins; Deuterium Exchange Measurement; Glutamic Acid; Glutamine; Kinetics; Phenylalanine; Photoreceptors, Microbial; Quantum Theory; Recombinant Proteins; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Thermodynamics; Thiocyanates; Threonine; Tyrosine; Valine | 2004 |
Local gamma-aminobutyric acid and glutamate circuit control of hypophyseotrophic corticotropin-releasing factor neuron activity in the paraventricular nucleus of the hypothalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Corticotropin-Releasing Hormone; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Microscopy, Electron; Neurons; Organ Culture Techniques; Paraventricular Hypothalamic Nucleus; Radiometry; Rats; Rats, Sprague-Dawley; Synapses; Valine | 2004 |
BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas.
Topics: Adult; Aged; Blotting, Southern; Carcinoma, Papillary; Female; Gene Amplification; Glutamic Acid; Humans; Male; Middle Aged; Molecular Biology; Mutation; Nuclear Receptor Coactivators; Oncogene Proteins; Oncogene Proteins, Fusion; Protein-Tyrosine Kinases; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Neoplasms; Transcription Factors; Valine | 2004 |
Polymorphisms of the prion protein gene (PRNP) in a Korean population.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Codon; Gene Frequency; Genotype; Glutamic Acid; Heterozygote; Homozygote; Humans; Korea; Lysine; Methionine; Molecular Sequence Data; Open Reading Frames; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prions; Valine | 2004 |
Irreversible loss of a subpopulation of cortical interneurons in the absence of glutamatergic network activity.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Bicuculline; Calbindin 2; Calcium; Calcium-Binding Proteins; Cell Count; Cell Size; Cells, Cultured; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; In Situ Nick-End Labeling; Interneurons; Nerve Net; Parvalbumins; Picrotoxin; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Time Factors; Valine | 2004 |
High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons.
Topics: Age Factors; Animals; Animals, Newborn; Blotting, Western; Bromodeoxyuridine; Cell Line; Cerebral Cortex; DNA-Binding Proteins; Embryo, Mammalian; Female; Glutamic Acid; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Kidney; LDL-Receptor Related Proteins; Male; Mice; Mice, Mutant Strains; Nerve Tissue Proteins; Neurons; Neuropeptides; Phenylalanine; POU Domain Factors; Precipitin Tests; Pregnancy; Receptors, Cell Surface; Receptors, LDL; Receptors, Lipoprotein; Reelin Protein; Staining and Labeling; T-Box Domain Proteins; Trans-Activators; Valine | 2004 |
Spectral deconvolution of chemical mixtures by covariance NMR.
Topics: Amino Acids; Buffers; Deuterium; Glutamic Acid; Leucine; Magnetic Resonance Spectroscopy; Principal Component Analysis; Valine | 2004 |
Stimulation of N-methyl-D-aspartate receptors, AMPA receptors or metabotropic glutamate receptors leads to rapid internalization of AMPA receptors in cultured nucleus accumbens neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Calcium; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Immunohistochemistry; Male; Neurons; Nucleus Accumbens; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors; Valine | 2004 |
Tetanization-induced pelvic-to-pudendal reflex plasticity in anesthetized rats.
Topics: Animals; Bicuculline; Decerebrate State; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Long-Term Potentiation; N-Methylaspartate; Nervous System Physiological Phenomena; Neuronal Plasticity; Pelvis; Quinoxalines; Rats; Rats, Wistar; Reflex; Valine | 2004 |
Heterosynaptic co-activation of glutamatergic and dopaminergic afferents is required to induce persistent long-term potentiation.
Topics: Animals; Benzazepines; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Neurons, Afferent; Rats; Rats, Wistar; Synapses; Time Factors; Valine | 2004 |
Characterisation of the effects of ATPA, a GLU(K5) kainate receptor agonist, on GABAergic synaptic transmission in the CA1 region of rat hippocampal slices.
Topics: Animals; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Isoxazoles; Kainic Acid; Membrane Potentials; Neural Inhibition; Propionates; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Kainic Acid; Synaptic Transmission; Valine | 2004 |
Functional characterization of the yeast Ppz1 phosphatase inhibitory subunit Hal3: a mutagenesis study.
Topics: Amino Acid Motifs; Amino Acid Sequence; Catalysis; Cell Cycle Proteins; Dose-Response Relationship, Drug; Escherichia coli; Fungal Proteins; Genetic Complementation Test; Glutamic Acid; Histidine; Models, Genetic; Models, Molecular; Molecular Sequence Data; Mutagenesis; Mutagenesis, Site-Directed; Mutation; Phenotype; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Plasmids; Polymerase Chain Reaction; Protein Binding; Protein Phosphatase 1; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Valine | 2004 |
The effect of sugar, amino acid, metal ion, and NaCl on model Maillard reaction under pH control.
Topics: Alanine; Amino Acids; Arabinose; Arginine; Aspartic Acid; Biochemistry; Carbohydrates; Colorimetry; Copper; Cysteine; Fructose; Glucose; Glutamic Acid; Glycine max; Hot Temperature; Hydrogen-Ion Concentration; Ions; Iron; Isoleucine; Leucine; Lysine; Maltose; Metals; Models, Chemical; Phenylalanine; Proline; Serine; Sodium Chloride; Temperature; Time Factors; Valine; Xylose | 2004 |
Differentiation of mouse embryonic stem cells into a defined neuronal lineage.
Topics: Animals; Bicuculline; Blotting, Western; Calmodulin-Binding Proteins; Carrier Proteins; Cell Count; Cell Differentiation; Cell Lineage; Cells, Cultured; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Eye Proteins; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; GABA Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Homeodomain Proteins; Immunohistochemistry; Indoles; Intermediate Filament Proteins; Membrane Potentials; Mice; Nerve Tissue Proteins; Nestin; Neuroglia; Neurogranin; Neurons; Paired Box Transcription Factors; Patch-Clamp Techniques; PAX6 Transcription Factor; Quinoxalines; Receptor, Nerve Growth Factor; Receptor, trkA; Receptors, AMPA; Receptors, Nerve Growth Factor; Repressor Proteins; Stem Cells; Synaptophysin; Tetrodotoxin; Time Factors; Tretinoin; Tubulin; Valine | 2004 |
Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility.
Topics: Animals; Antigens; Binding Sites; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cytoplasm; Cytoskeletal Proteins; Glutamic Acid; Humans; Microscopy, Electron; Microscopy, Fluorescence; Mutation; Phorbol Esters; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Protein Structure, Tertiary; Proteoglycans; Rats; Threonine; Valine | 2004 |
The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals.
Topics: Alkanes; Animals; Bicuculline; Bungarotoxins; Chromatography, High Pressure Liquid; Cyclopropanes; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Indoles; Linoleic Acid; Lysine; Male; Maleimides; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Presynaptic Terminals; Protein Kinase C; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Nicotinic; Receptors, Presynaptic; Synaptic Transmission; Valine | 2005 |
Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.
Topics: Alanine; Aldehyde-Lyases; Aldehydes; Amino Acid Substitution; Arginine; Aspartic Acid; Carboxy-Lyases; Catalysis; Decarboxylation; Enzyme Stability; Escherichia coli Proteins; Evolution, Molecular; Formaldehyde; Glutamic Acid; Histidine; Ketoses; Methylomonas; Orotidine-5'-Phosphate Decarboxylase; Ribulosephosphates; Stereoisomerism; Threonine; Valine | 2005 |
The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Blotting, Western; Brain; Calcium; Cell Line; Cell Size; Cloning, Molecular; Dendritic Spines; DNA-Binding Proteins; Drug Interactions; Egtazic Acid; Ephrin-B1; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Humans; Immunohistochemistry; Immunoprecipitation; Microscopy, Immunoelectron; Models, Neurological; Neoplasm Proteins; Neurons; p21-Activated Kinases; Protein Serine-Threonine Kinases; Proteins; rac1 GTP-Binding Protein; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Antisense; RNA, Small Interfering; Synaptosomes; T-Lymphoma Invasion and Metastasis-inducing Protein 1; Tetrodotoxin; Time Factors; Transcription Factors; Transfection; Valine | 2005 |
Thr-774 (transmembrane segment M5), Val-920 (M8), and Glu-954 (M9) are involved in Na+ transport, and Gln-923 (M8) is essential for Na,K-ATPase activity.
Topics: 4-Nitrophenylphosphatase; Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding Sites; Cations; Cell Membrane; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Glutamine; Green Fluorescent Proteins; HeLa Cells; Humans; Kinetics; Lipid Bilayers; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Ouabain; Oxygen; Phosphorylation; Potassium; Protein Conformation; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Sodium; Sodium Chloride; Sodium-Potassium-Exchanging ATPase; Threonine; Transfection; Valine | 2005 |
Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction.
Topics: Base Sequence; DNA; DNA Mutational Analysis; Dysplastic Nevus Syndrome; Glutamic Acid; Humans; Ligases; Melanocytes; Melanoma; Molecular Sequence Data; Mutation; Nevus; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Skin Neoplasms; Valine | 2005 |
[Hydrophobicity of reactive site loop of SCCA1 affects its binding to HBV].
Topics: Antigens, Neoplasm; Binding Sites; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; Glutamic Acid; Hepatitis B virus; Humans; Hydrophobic and Hydrophilic Interactions; Liver Neoplasms; Protein Binding; Receptors, Virus; Serpins; Valine | 2005 |
Transmembrane peptides from tyrosine kinase receptor. Mutation-related behavior in a lipid bilayer investigated by molecular dynamics simulations.
Topics: Amino Acid Sequence; Dimerization; Dimyristoylphosphatidylcholine; Glutamic Acid; Hydrogen Bonding; Indicators and Reagents; Lipid Bilayers; Lipids; Molecular Sequence Data; Mutation; Peptides; Protein Conformation; Protein Structure, Secondary; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Software; Time Factors; Valine | 2005 |
Gliotoxicity in hippocampal cultures is induced by transportable, but not by nontransportable, glutamate uptake inhibitors.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Cell Death; Cells, Cultured; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Neuroglia; Neurons; Neurotoxins; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Receptors, N-Methyl-D-Aspartate; Valine | 2005 |
Short communication: Amino acids antagonistic to the amino acids inhibitory for growth rate of mixed ruminal bacteria.
Topics: Amino Acids; Animals; Bacteria; Cattle; Diet; Feedback, Physiological; Female; Fermentation; Glutamic Acid; Isoleucine; Leucine; Nitrogen; Phenylalanine; Rumen; Threonine; Tryptophan; Tyrosine; Valine | 2005 |
Electrophysiological properties of human hypothalamic hamartomas.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Bicuculline; Cadmium Chloride; Child; Child, Preschool; Drug Interactions; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Glutamic Acid; Hamartoma; Humans; Hypothalamus; Immunohistochemistry; In Vitro Techniques; Infant; Isoenzymes; Kainic Acid; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Periodicity; Phosphopyruvate Hydratase; Potassium Channel Blockers; Tetraethylammonium; Tetrodotoxin; Valine | 2005 |
Cooperative glutamatergic and cholinergic mechanisms generate short-term modifications of synaptic effectiveness in prepositus hypoglossi neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Animals; Animals, Newborn; Atropine; Brain Stem; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoglossal Nerve; In Vitro Techniques; Membrane Potentials; Muscarinic Antagonists; Nerve Net; Neurons; Patch-Clamp Techniques; Pirenzepine; Rats; Synaptic Transmission; Time Factors; Valine | 2005 |
Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis.
Topics: Adult; Alanine; Amino Acid Substitution; Arginine; Asian People; Breast Neoplasms; Case-Control Studies; China; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Middle Aged; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Polymorphism, Genetic; Risk; Valine; X-ray Repair Cross Complementing Protein 1 | 2006 |
Dendrites contain a spacing pattern.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cells, Cultured; Cerebellum; Dendrites; Diffusion; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Mice; Microtubule-Associated Proteins; Microtubules; Morphogenesis; Neocortex; Neurons; Nocodazole; Paclitaxel; Potassium Chloride; Pyramidal Cells; Rats; Sodium Channel Blockers; Staining and Labeling; Tetrodotoxin; Valine | 2006 |
Phenotypic and cellular expression of two novel connexin32 mutations causing CMT1X.
Topics: Aged; Amino Acid Substitution; Central Nervous System Diseases; Charcot-Marie-Tooth Disease; Connexins; Demyelinating Diseases; Electromyography; Female; Gap Junction beta-1 Protein; Glutamic Acid; HeLa Cells; Humans; Leucine; Male; Middle Aged; Mutation, Missense; Neural Conduction; Pedigree; Phenotype; Polyneuropathies; Proline; Sural Nerve; Valine | 2006 |
Novel PRKCG/SCA14 mutation in a Dutch spinocerebellar ataxia family: expanding the phenotype.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Atrophy; Basal Ganglia Diseases; Cerebellum; DNA Mutational Analysis; Exons; Female; Glutamic Acid; Humans; Isoenzymes; Magnetic Resonance Imaging; Male; Middle Aged; Mutation, Missense; Myoclonus; Netherlands; Pedigree; Phenotype; Protein Kinase C; Spinocerebellar Ataxias; Tremor; Valine | 2006 |
Effects of amino acid on morphological development and nucleus formation of arachidonic acid-producing filamentous micro-organism, Mortierella alpina.
Topics: Alanine; Amino Acids; Arachidonic Acid; Cell Nucleus; Culture Media; Glutamic Acid; Hyphae; Image Interpretation, Computer-Assisted; Mortierella; Sodium Glutamate; Valine | 2006 |
Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese.
Topics: Alanine; Asian People; Case-Control Studies; Cytochrome P-450 CYP11B2; Epistasis, Genetic; Female; G-Protein-Coupled Receptor Kinase 4; Glutamic Acid; Glutamine; Humans; Hypertension; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein Serine-Threonine Kinases; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, beta-2; Tyrosine 3-Monooxygenase; Valine | 2006 |
Correlation between B-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma: data from a multicentric Italian study and review of the literature.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Papillary; DNA Mutational Analysis; Female; Glutamic Acid; Humans; Italy; Male; Middle Aged; Molecular Epidemiology; Point Mutation; Prevalence; Prognosis; Proto-Oncogene Proteins B-raf; Thyroid Neoplasms; Valine | 2006 |
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
Topics: Cells, Cultured; Disease Progression; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Glutamic Acid; Humans; Melanocytes; Melanoma; Mutation; Neoplasm Invasiveness; Proto-Oncogene Proteins B-raf; Signal Transduction; Valine | 2007 |
Right-handed DNA supercoiling by an octameric form of histone-like protein HU: modulation of cellular transcription.
Topics: Carrier Proteins; Chromatin; Dimerization; DNA-Binding Proteins; DNA, Superhelical; Escherichia coli Proteins; Genetic Markers; Glutamic Acid; Histones; Leucine; Lysine; Microscopy, Atomic Force; Mutation; Protein Isoforms; Transcription Factors; Valine | 2006 |
Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Child; Female; Gene Frequency; Glutamic Acid; Humans; Male; Melanoma; Middle Aged; Multivariate Analysis; Mutation; Pigmentation; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Threonine; Valine | 2007 |
Cold exposure and associated metabolic changes in adult tropical beetles exposed to fluctuating thermal regimes.
Topics: Acclimatization; Alanine; Amino Acids; Amino Acids, Essential; Animals; Arginine; Body Temperature; Cold Temperature; Glucose; Glutamic Acid; Glutamine; Glycerol; Inositol; Lysine; Proline; Ribitol; Sorbitol; Survival Analysis; Temperature; Tenebrio; Threonine; Trehalose; Tropical Climate; Valine | 2007 |
BRAF V600E mutation in anaplastic thyroid carcinomas and their accompanying differentiated carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Base Sequence; Carcinoma; Disease Progression; DNA Mutational Analysis; Female; Gene Frequency; Glutamic Acid; Humans; Male; Middle Aged; Models, Biological; Mutation, Missense; Proto-Oncogene Proteins B-raf; Thyroid Neoplasms; Valine | 2007 |
Electronic structure of the PYP chromophore in its native protein environment.
Topics: Amino Acid Sequence; Arginine; Bacterial Proteins; Cysteine; Glutamic Acid; Models, Molecular; Phenylalanine; Photoreceptors, Microbial; Threonine; Tyrosine; Valine | 2007 |
Among the branched-chain amino acids, only valine metabolism is up-regulated in astrocytes during glutamate exposure.
Topics: Amino Acids, Branched-Chain; Animals; Astrocytes; Cells, Cultured; Cerebellum; Glutamic Acid; Mice; Up-Regulation; Valine | 2007 |
Amino acid composition of two masticatory nuts (Cola acuminata and Garcinia kola) and a snack nut (Anacardium occidentale).
Topics: Amino Acids; Amino Acids, Acidic; Amino Acids, Essential; Anacardium; Arginine; Aspartic Acid; Cola; Cystine; Garcinia kola; Glutamic Acid; Isoelectric Point; Nuts; Threonine; Valine | 2007 |
Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Isonicotinic Acids; Male; Neurons; Olfactory Bulb; Pyridazines; Rats; Rats, Sprague-Dawley; Valine | 2007 |
D-Serine inhibits AMPA receptor-mediated current in rat hippocampal neurons.
Topics: Action Potentials; Amino Acids; Aminobutyrates; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Molecular Structure; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism; Valine | 2007 |
BRAF V600E mutation and p27 kip1 expression in papillary carcinomas of the thyroid
Topics: Adult; Biomarkers, Tumor; Carcinoma, Papillary; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Proto-Oncogene Proteins B-raf; Sequence Analysis, DNA; Thyroid Neoplasms; Valine | 2007 |
A minor beta-structured conformation is the active state of a fusion peptide of vesicular stomatitis virus glycoprotein.
Topics: Amino Acid Sequence; Asparagine; Circular Dichroism; Glutamic Acid; Glycoproteins; Hydrogen-Ion Concentration; Liposomes; Micelles; Models, Chemical; Molecular Conformation; Molecular Sequence Data; Molecular Weight; Nuclear Magnetic Resonance, Biomolecular; Peptides; Phosphatidylcholines; Phosphatidylserines; Protein Structure, Secondary; Sodium Dodecyl Sulfate; Tyrosine; Valine; Vesicular stomatitis Indiana virus | 2008 |
ABCA4 mutations and discordant ABCA4 alleles in patients and siblings with bull's-eye maculopathy.
Topics: Adolescent; Adult; Aged; Alanine; Alleles; ATP-Binding Cassette Transporters; Cohort Studies; Female; Glutamic Acid; Glycine; Humans; Macula Lutea; Male; Middle Aged; Mutation; Mutation, Missense; Pedigree; Phenotype; Retinal Diseases; Siblings; Valine | 2007 |
Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
Topics: Alanine; Arginine; Biomarkers, Tumor; Breast Neoplasms; Centrosome; DNA, Complementary; Factor Analysis, Statistical; Female; Genes, BRCA1; Genetic Predisposition to Disease; Glutamic Acid; Glutamine; Glycine; Humans; Immunohistochemistry; Keratins; Mutation, Missense; Nucleic Acid Amplification Techniques; Plasmids; Polymorphism, Single Nucleotide; Predictive Value of Tests; Receptors, Estrogen; Risk Assessment; Risk Factors; Sequence Analysis, DNA; Valine | 2007 |
B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells.
Topics: Amino Acid Substitution; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Genes, cdc; Glutamic Acid; Humans; Melanoma; Phosphorylation; Polymorphism, Single Nucleotide; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins B-raf; Signal Transduction; Spindle Apparatus; Transfection; Valine | 2008 |
Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties.
Topics: Amino Acids; Anti-Infective Agents; Cell Line; Cell Proliferation; Curcumin; Drug Design; Fatty Acids, Unsaturated; Glutamic Acid; Glycine; Humans; Valine | 2008 |
Endocannabinoids mediate neuron-astrocyte communication.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Astrocytes; Calcium; Cannabinoid Receptor Modulators; Cell Communication; Egtazic Acid; Electric Stimulation; Endocannabinoids; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Photolysis; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Type C Phospholipases; Valine | 2008 |
Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex.
Topics: Acetylcholine; Analysis of Variance; Animals; Choline; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electrochemistry; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Male; Mecamylamine; Neostigmine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Pyridines; Pyrrolidines; Quinoxalines; Rats; Sodium Channel Blockers; Tetrodotoxin; Valine | 2008 |
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.
Topics: Animals; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromones; Disease Progression; Glutamic Acid; Humans; MAP Kinase Signaling System; Melanocytes; Melanoma; Mice; Morpholines; Mutant Proteins; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Signal Transduction; Valine | 2008 |
In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.
Topics: Amino Acid Substitution; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Codon; Drug Screening Assays, Antitumor; Glutamic Acid; Humans; Melanoma; Mutant Proteins; Mutation; Phenothiazines; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; ras Proteins; Reproducibility of Results; Valine | 2008 |
Introduction into Ca(v)2.1 of the homologous mutation of Ca(v)1.2 causing the Timothy syndrome questions the role of V421 in the phenotypic definition of P-type Ca(2+) channel.
Topics: Alanine; Animals; Arginine; Arrhythmias, Cardiac; Calcium; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, R-Type; Cation Transport Proteins; Cognition Disorders; Genotype; Glutamic Acid; Glycine; GTP-Binding Proteins; Ion Channel Gating; Kinetics; Membrane Potentials; Mutation; Phenotype; Rats; Syndrome; Valine; Xenopus | 2008 |
Development of a temperature gradient focusing method for in situ extraterrestrial biomarker analysis.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Aspartic Acid; Biomarkers; Countercurrent Distribution; Electrophoresis, Microchip; Extraterrestrial Environment; Glutamic Acid; Glycine; Life; Mars; Serine; Soil; Space Flight; Stereoisomerism; Temperature; Valine | 2008 |
Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Microscopy, Electron, Scanning; N-Methylaspartate; Potassium Chloride; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium; Valine | 2008 |
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Topics: Amino Acid Substitution; Base Sequence; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; DNA Mutational Analysis; Drug Resistance, Neoplasm; Gene Amplification; Glutamic Acid; Humans; Imidazoles; Melanoma; Molecular Sequence Data; Mutation; Proto-Oncogene Proteins B-raf; Valine | 2008 |
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.
Topics: Apoptosis; Benzenesulfonates; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glutamic Acid; Humans; Melanoma; Mitogen-Activated Protein Kinase Kinases; Mutation; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Pyridines; RNA, Small Interfering; Signal Transduction; Sorafenib; Valine | 2009 |
BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients.
Topics: Adult; Amino Acid Substitution; Carcinoma, Papillary; Disease-Free Survival; Female; Genetic Linkage; Genetic Predisposition to Disease; Genetics, Population; Glutamic Acid; Humans; Japan; Male; Middle Aged; Neoplasm Staging; Point Mutation; Prognosis; Proto-Oncogene Proteins B-raf; Risk Factors; Thyroid Neoplasms; Valine | 2009 |
The role of the C-terminal region of cyanophycin synthetase from Nostoc ellipsosporum NE1 in its enzymatic activity and thermostability: a key function of Glu(856).
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Codon, Terminator; Enzyme Activation; Enzyme Stability; Escherichia coli; Gene Expression Regulation, Bacterial; Glutamic Acid; Leucine; Molecular Sequence Data; Nostoc; Peptide Synthases; Temperature; Valine | 2009 |
Two novel Jk(null) alleles derived from 222C>A in Exon 5 and 896G>A in Exon 9 of the JK gene.
Topics: 5' Untranslated Regions; Alleles; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; DNA; Exons; Glutamic Acid; Heterozygote; Humans; Introns; Kidd Blood-Group System; Lysine; Molecular Sequence Data; Mutation; Mutation, Missense; Polymerase Chain Reaction; Sequence Analysis, DNA; Valine | 2009 |
Abnormal network activity in a targeted genetic model of human double cortex.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Bicuculline; Cerebral Cortex; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Electroporation; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Green Fluorescent Proteins; Humans; In Vitro Techniques; Malformations of Cortical Development; Membrane Potentials; Microtubule-Associated Proteins; Mutation; Nerve Net; Neurons; Neuropeptides; Pregnancy; Quinoxalines; Rats; Rats, Wistar; RNA, Small Interfering; Sodium Channel Blockers; Tetrodotoxin; Valine | 2009 |
Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways.
Topics: Animals; Arginine; Cannabinoid Receptor Modulators; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Dronabinol; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glucocorticoids; Glutamic Acid; GTP-Binding Proteins; Guanosine Diphosphate; Hypothalamus; In Vitro Techniques; Male; Neurons; Nitric Oxide; Nitric Oxide Donors; Patch-Clamp Techniques; Penicillamine; Piperidines; Pyrans; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Rimonabant; Signal Transduction; Synapses; Synaptic Transmission; Thionucleotides; Valine | 2009 |
Post-training infusion of glutamate into the bed nucleus of the stria terminalis enhanced inhibitory avoidance memory: an effect involving norepinephrine.
Topics: Acoustic Stimulation; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Memory; Motor Activity; Norepinephrine; Propranolol; Rats; Rats, Wistar; Septal Nuclei; Valine | 2009 |
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.
Topics: ADAM Proteins; ADAM10 Protein; Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Disease Models, Animal; Glutamic Acid; Humans; Isoleucine; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reaction Time; Swimming; Valine | 2009 |
Presynaptic muscarinic receptors enhance glutamate release at the mitral/tufted to granule cell dendrodendritic synapse in the rat main olfactory bulb.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Animals, Newborn; Biophysics; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Membrane Potentials; Models, Biological; Muscarinic Antagonists; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Picrotoxin; Pirenzepine; Presynaptic Terminals; Rats; Receptors, Muscarinic; Sodium Channel Blockers; Tetrodotoxin; Valine | 2009 |
NMDA receptor activation by spontaneous glutamatergic neurotransmission.
Topics: Analysis of Variance; Animals; Animals, Newborn; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Miniature Postsynaptic Potentials; Neocortex; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Valine | 2009 |
Concomitant t(3;3)(q21;q26), trisomy 19, and E255V mutation associated with imatinib mesylate resistance in chronic myelogenous leukemia.
Topics: Amino Acid Substitution; Antineoplastic Agents; Base Sequence; Benzamides; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 3; Drug Resistance, Neoplasm; Female; Glutamic Acid; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Mutation, Missense; Piperazines; Prognosis; Pyrimidines; Translocation, Genetic; Trisomy; Valine | 2009 |
Glutamate is the major anaplerotic substrate in the tricarboxylic acid cycle of isolated rumen epithelial and duodenal mucosal cells from beef cattle.
Topics: Animals; Carbon Isotopes; Cattle; Citric Acid Cycle; Diet; Duodenum; Epithelial Cells; Gas Chromatography-Mass Spectrometry; Glucose; Glutamic Acid; Glutamine; Intestinal Mucosa; Lactic Acid; Leucine; Male; Pyruvic Acid; Rumen; Valine | 2009 |
KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Movement; Cerebral Cortex; Electroporation; Embryo, Mammalian; Female; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Green Fluorescent Proteins; Homeodomain Proteins; Interneurons; K Cl- Cotransporters; LIM-Homeodomain Proteins; Membrane Potentials; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microtubule-Associated Proteins; Models, Biological; Muscimol; Nerve Tissue Proteins; Nifedipine; omega-Conotoxin GVIA; Organ Culture Techniques; Pregnancy; Quinoxalines; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Sequence Deletion; Symporters; Transcription Factors; Valine | 2009 |
Synaptic and extrasynaptic factors governing glutamatergic retinal waves.
Topics: Amino Acid Transport Systems, Acidic; Animals; Animals, Newborn; Aspartic Acid; Calcium; Dihydro-beta-Erythroidine; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; N-Methylaspartate; Neural Inhibition; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Retinal Ganglion Cells; Synapses; Synaptic Transmission; Time Factors; Valine; Vesicular Glutamate Transport Protein 1 | 2009 |
Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Biophysics; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Glial Fibrillary Acidic Protein; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Lidocaine; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Time Factors; Tubulin; Valine | 2009 |
Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded.
Topics: Alleles; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Bone Marrow; Chromosomes, Human, Pair 6; Exons; Gene Conversion; Gene Frequency; Glutamic Acid; HLA-B27 Antigen; Humans; Living Donors; Molecular Sequence Data; Sequence Alignment; Taiwan; Valine | 2009 |
BRAF V600E mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma in fine-needle aspiration biopsies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Biopsy, Fine-Needle; Carcinoma, Papillary; DNA Mutational Analysis; Female; Glutamic Acid; Humans; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Thyroid Neoplasms; Valine; Young Adult | 2009 |
Strategy for identification by mass spectrometry of a new human hemoglobin variant with two mutations in Cis in the beta-globin chain: Hb S-Clichy [beta6(A3)Glu-->Val; beta8(A5)Lys-->Thr].
Topics: Anemia, Sickle Cell; beta-Globins; Chromatography, Liquid; Female; Glutamic Acid; Hemoglobin, Sickle; Hemoglobins, Abnormal; Humans; Lysine; Mass Spectrometry; Middle Aged; Mutation; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Valine | 2009 |
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Connectin; Elasticity; Glutamic Acid; Heart Ventricles; Humans; Lysine; Male; Mice; Molecular Sequence Data; Muscle Proteins; Muscle Tonus; Mutagenesis, Site-Directed; Mutation; Myocardial Contraction; Myocardium; Peptide Fragments; Phosphorylation; Proline; Protein Kinase C-alpha; Protein Kinases; Protein Phosphatase 1; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Signal Transduction; Swine; Tandem Mass Spectrometry; Time Factors; Valine | 2009 |
Polyclonality of BRAF mutations in acquired melanocytic nevi.
Topics: Adult; Aged; Female; Glutamic Acid; Humans; Japan; Male; Melanocytes; Middle Aged; Mutation; Nevus, Pigmented; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins B-raf; Sequence Analysis, DNA; Valine | 2009 |
D-amino acids govern stationary phase cell wall remodeling in bacteria.
Topics: Alanine; Amino Acid Isomerases; Amino Acids; Bacillus subtilis; Cell Wall; Down-Regulation; Glutamic Acid; Isoleucine; Leucine; Methionine; Oligopeptides; Peptidoglycan; Polysaccharides; Stereoisomerism; Valine; Vibrio cholerae | 2009 |
Time-resolved transcriptome analysis of Bacillus subtilis responding to valine, glutamate, and glutamine.
Topics: Bacillus subtilis; Bacterial Physiological Phenomena; Bacterial Proteins; Biological Transport; Carbon; Fatty Acids; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genes, Bacterial; Glutamic Acid; Glutamine; Models, Biological; Nitrogen; Transcription, Genetic; Valine | 2009 |
Titin phosphorylation: myocardial passive stiffness regulated by the intracellular giant.
Topics: Amino Acid Motifs; Connectin; Elasticity; Glutamic Acid; Heart Ventricles; Humans; Lysine; Male; Muscle Proteins; Muscle Tonus; Myocardial Contraction; Myocardium; Phosphorylation; Proline; Protein Kinase C-alpha; Protein Kinases; Protein Phosphatase 1; Protein Processing, Post-Translational; Recombinant Proteins; Signal Transduction; Valine | 2009 |
Analgesic properties of the novel amino acid, isovaline.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; beta-Alanine; Chronic Disease; Cisterna Magna; Female; Formaldehyde; Glutamic Acid; Glycine; Hypnotics and Sedatives; Injections; Injections, Intravenous; Injections, Spinal; Mice; Models, Molecular; Pain; Pain Measurement; Postural Balance; Receptors, Glutamate; Strychnine; Valine | 2010 |
A heterozygous mutation of the insulin-like growth factor-I receptor causes retention of the nascent protein in the endoplasmic reticulum and results in intrauterine and postnatal growth retardation.
Topics: Amino Acid Substitution; Birth Weight; Body Size; Cognition Disorders; Endoplasmic Reticulum; Exons; Female; Fetal Growth Retardation; Glutamic Acid; Growth Disorders; Heterozygote; Humans; Infant, Newborn; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Intellectual Disability; Microcephaly; Mutation, Missense; Polymerase Chain Reaction; Receptor, IGF Type 1; Valine | 2010 |
Off-line concomitant release of dopamine and glutamate involvement in taste memory consolidation.
Topics: Amygdala; Animals; Avoidance Learning; Benzazepines; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Dopamine; Electrophoresis, Capillary; Glutamic Acid; Male; Memory; Microdialysis; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Taste; Valine | 2010 |
The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Carcinoma; Colonic Neoplasms; Female; Genes, ras; Glutamic Acid; Humans; Male; Microsatellite Instability; Middle Aged; Mutation, Missense; Neoplasm Staging; Prognosis; Proto-Oncogene Proteins B-raf; Survival Analysis; Valine | 2010 |
Metaplasticity at single glutamatergic synapses.
Topics: Anesthetics, Local; Animals; Biophysics; Dendritic Spines; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Long-Term Potentiation; Models, Biological; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Tetanus Toxin; Tetrodotoxin; Time Factors; Transfection; Valine | 2010 |
Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases.
Topics: Adult; Amino Acid Substitution; Carcinoma, Papillary; Cohort Studies; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Male; Middle Aged; Neoplasm Invasiveness; Point Mutation; Proto-Oncogene Proteins B-raf; Retrospective Studies; Thyroid Neoplasms; Tumor Burden; Valine | 2010 |
Ligand-induced changes in the conformational stability and flexibility of glutamate dehydrogenase and their role in catalysis and regulation.
Topics: Allosteric Regulation; Animals; Biocatalysis; Calorimetry, Differential Scanning; Cattle; Circular Dichroism; Enzyme Activation; Enzyme Stability; Glutamate Dehydrogenase; Glutamic Acid; Guanidine; Hot Temperature; Kinetics; Ligands; Models, Molecular; Protein Binding; Protein Conformation; Protein Folding; Substrate Specificity; Valine | 2010 |
An inexpensive, specific and highly sensitive protocol to detect the BrafV600E mutation in melanoma tumor biopsies and blood.
Topics: Amino Acid Substitution; Biopsy; Blood Chemical Analysis; Cell Line, Tumor; Cost-Benefit Analysis; Cytogenetic Analysis; DNA Mutational Analysis; Glutamic Acid; HT29 Cells; Humans; Melanoma; Models, Biological; Proto-Oncogene Proteins B-raf; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Skin Neoplasms; Valine | 2010 |
Clinical, pathological and genetic evaluations of Chinese patients with autosomal-dominant hypophosphatasia.
Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Child; China; Dental Cementum; Dentin; Exons; Female; Genes, Dominant; Genotype; Glutamic Acid; Heterozygote; Humans; Hypophosphatasia; Male; Mutation; Mutation, Missense; Pedigree; Phenotype; Thymine; Tooth Exfoliation; Tooth, Deciduous; Valine | 2010 |
Frequency-dependent recruitment of fast amino acid and slow neuropeptide neurotransmitter release controls gonadotropin-releasing hormone neuron excitability.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Anterior Thalamic Nuclei; Biophysics; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gonadotropin-Releasing Hormone; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Neuropeptides; Neurotransmitter Agents; Patch-Clamp Techniques; Reaction Time; Receptors, G-Protein-Coupled; Receptors, Kisspeptin-1; Statistics, Nonparametric; Synaptic Transmission; Valine | 2011 |
Preconditioning effects of tumor necrosis factor-α and glutamate on calcium dynamics in rat organotypic hippocampal cultures.
Topics: Animals; Animals, Newborn; Calcium; Cell Death; Cell Survival; Drug Administration Schedule; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Imidazoles; Male; Nonlinear Dynamics; Organ Culture Techniques; Propidium; Pyridines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Valine | 2011 |
Isoleucine 259 and isoleucine 260 residues in Streptococcus gordonii soluble inorganic pyrophosphatase play an important role in enzyme activity.
Topics: Aspartic Acid; Binding Sites; Catalysis; Catalytic Domain; Glutamic Acid; Inorganic Pyrophosphatase; Isoleucine; Mutagenesis, Site-Directed; Streptococcus gordonii; Valine | 2011 |
Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy.
Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Biophysics; Brain Mapping; Confidence Intervals; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Magnesium; Male; Middle Aged; Nerve Net; Potassium Chloride; Quinoxalines; Valine; Young Adult | 2011 |
Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Cells, Cultured; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Lidocaine; Male; Mice; Mice, Knockout; Neurons; Patch-Clamp Techniques; Polyamines; Receptors, AMPA; Tetrodotoxin; Valine | 2011 |
Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.
Topics: Adult; Aspartic Acid; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Creatine; Female; Genetic Association Studies; Genotype; Glutamic Acid; Hippocampus; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Memory; Methionine; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Protons; Schizophrenia; Valine; Verbal Learning | 2012 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebral Infarction; Cerebrosides; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glucose; Glutamic Acid; Hippocampus; Hypoxia; In Vitro Techniques; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts; Valine | 2012 |
Stability of BRAF V600E mutation in metastatic melanoma: new insights for therapeutic success?
Topics: Amino Acid Substitution; Disease Progression; Glutamic Acid; Humans; Melanoma; Mutation, Missense; Neoplasm Metastasis; Prognosis; Proto-Oncogene Proteins B-raf; Selection, Genetic; Skin Neoplasms; Treatment Outcome; Valine | 2011 |
A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.
Topics: Animals; Biocatalysis; Calorimetry, Differential Scanning; Catalytic Domain; Cattle; Crystallography, X-Ray; Enzyme Inhibitors; Enzyme Stability; Europium; Glutamate Dehydrogenase; Glutamic Acid; Kinetics; Liver; Models, Molecular; NADP; Protein Conformation; Protein Subunits; Valine; Zinc; Zinc Acetate | 2011 |
Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort.
Topics: Adult; Aged; Amino Acid Substitution; Asian People; Cohort Studies; DNA Mutational Analysis; Female; Genes, ras; Glutamic Acid; Humans; Male; Melanoma; Middle Aged; Mutation Rate; Mutation, Missense; Prognosis; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Valine | 2012 |
GABA(B) restrains release from singly-evoked GABA terminals.
Topics: Analysis of Variance; Animals; Benzylamines; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Neurons; Phosphinic Acids; Pyridazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Sodium Channel Blockers; Solitary Nucleus; Synapses; Tetrodotoxin; Valine | 2011 |
BRAFV600E mutation, TIMP-1 upregulation, and NF-κB activation: closing the loop on the papillary thyroid cancer trilogy.
Topics: Adult; Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Cell Transformation, Neoplastic; Disease Progression; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Glutamic Acid; Humans; Male; Middle Aged; Mutation, Missense; Neoplasm Invasiveness; NF-kappa B; Proto-Oncogene Proteins B-raf; Signal Transduction; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tissue Inhibitor of Metalloproteinase-1; Tumor Cells, Cultured; Up-Regulation; Valine | 2011 |
Genome-wide alterations in gene methylation by the BRAF V600E mutation in papillary thyroid cancer cells.
Topics: Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Cluster Analysis; CpG Islands; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genome, Human; Glutamic Acid; Humans; Microarray Analysis; Mutation, Missense; Proto-Oncogene Proteins B-raf; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Cells, Cultured; Valine | 2011 |
Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche.
Topics: Action Potentials; Animals; Animals, Newborn; Bacterial Proteins; Biophysical Phenomena; Cell Adhesion Molecules, Neuronal; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Matrix Proteins; GABA Antagonists; Glutamic Acid; Green Fluorescent Proteins; Interneurons; Iontophoresis; Luminescent Proteins; Lysine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Neurological; Nerve Net; Nerve Tissue Proteins; Neural Inhibition; Neurogenesis; Neuropeptide Y; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Picrotoxin; Pro-Opiomelanocortin; Quinoxalines; Reelin Protein; Serine Endopeptidases; Stem Cell Niche; Synaptic Potentials; Time Factors; Valine | 2011 |
Immunohistochemical testing of BRAF V600E status in 1,120 tumor tissue samples of patients with brain metastases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Female; Genetic Predisposition to Disease; Glutamic Acid; HEK293 Cells; Humans; Immunohistochemistry; Male; Middle Aged; Point Mutation; Proto-Oncogene Proteins B-raf; Valine; Young Adult | 2012 |
Two free radical pathways mediate chemical hypoxia-induced glutamate release in synaptosomes from the prefrontal cortex.
Topics: Adenosine Triphosphate; Animals; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Free Radicals; Glutamic Acid; Hydrogen Peroxide; Hypoxia; Lipid Peroxidation; Male; Mitochondrial Proton-Translocating ATPases; Oxidants; Prefrontal Cortex; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium Cyanide; Synaptosomes; Valine | 2012 |
The Akt inhibitor MK2206 synergizes, but perifosine antagonizes, the BRAF(V600E) inhibitor PLX4032 and the MEK1/2 inhibitor AZD6244 in the inhibition of thyroid cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carcinoma; Cell Proliferation; Down-Regulation; Drug Antagonism; Drug Evaluation, Preclinical; Drug Synergism; Glutamic Acid; Heterocyclic Compounds, 3-Ring; Humans; Indoles; Mutant Proteins; Oncogene Protein v-akt; Phosphorylcholine; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sulfonamides; Thyroid Neoplasms; Tumor Cells, Cultured; Valine; Vemurafenib | 2012 |
The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma.
Topics: Amino Acid Substitution; Base Sequence; Carcinoma; Carcinoma, Papillary; Clone Cells; DNA Mutational Analysis; Gene Frequency; Glutamic Acid; Humans; Mutation, Missense; Proto-Oncogene Proteins B-raf; Retrospective Studies; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Cells, Cultured; Valine | 2012 |
Sex difference in stress-induced enhancement of hippocampal CA1 long-term depression during puberty.
Topics: Adrenalectomy; Androgens; Animals; Animals, Newborn; Aspartic Acid; CA1 Region, Hippocampal; Corticosterone; Dexamethasone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glucocorticoids; Glutamic Acid; In Vitro Techniques; Long-Term Synaptic Depression; Male; Methoxyhydroxyphenylglycol; N-Methylaspartate; Neurons; Ovariectomy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Statistics, Nonparametric; Stress, Psychological; Synaptosomes; Testosterone; Valine | 2012 |
Regulation of neuronal input transformations by tunable dendritic inhibition.
Topics: Animals; Biophysics; Cerebral Cortex; Channelrhodopsins; Dependovirus; DNA-Binding Proteins; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; In Vitro Techniques; Interneurons; Ligand-Gated Ion Channels; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Neurological; Mutation; Neural Inhibition; Parvalbumins; Patch-Clamp Techniques; Photic Stimulation; Pyramidal Cells; Pyridazines; Receptors, Glycine; RNA, Small Interfering; Synapses; Synaptic Transmission; Transcription Factors; Transduction, Genetic; Valine | 2012 |
Development and validation of a real-time quantification assay to detect and monitor BRAFV600E mutations in hairy cell leukemia.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; DNA Mutational Analysis; Early Detection of Cancer; Female; Follow-Up Studies; Glutamic Acid; Humans; Leukemia, Hairy Cell; Male; Middle Aged; Monitoring, Physiologic; Mutation, Missense; Proto-Oncogene Proteins B-raf; Real-Time Polymerase Chain Reaction; Valine; Young Adult | 2012 |
Clinical implication of highly sensitive detection of the BRAF V600E mutation in fine-needle aspirations of thyroid nodules: a comparative analysis of three molecular assays in 4585 consecutive cases in a BRAF V600E mutation-prevalent area.
Topics: Adult; Amino Acid Substitution; Biopsy, Fine-Needle; Carcinoma; Carcinoma, Papillary; Cohort Studies; Cytological Techniques; DNA Mutational Analysis; Female; Gene Frequency; Glutamic Acid; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Mutation, Missense; Prevalence; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroid Nodule; Valine | 2012 |
Role of ultrasonographic/clinical profile, cytology, and BRAF V600E mutation evaluation in thyroid nodule screening for malignancy: a prospective study.
Topics: Adult; Amino Acid Substitution; Biopsy, Fine-Needle; Carcinoma; Carcinoma, Papillary; Cytological Techniques; DNA Mutational Analysis; Early Detection of Cancer; Female; Glutamic Acid; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Mutation, Missense; Predictive Value of Tests; Prospective Studies; Proto-Oncogene Proteins B-raf; Retrospective Studies; Sensitivity and Specificity; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroid Nodule; Ultrasonography, Interventional; Valine | 2012 |
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.
Topics: Amino Acid Substitution; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Enzyme Activation; Fibroblasts; Glutamic Acid; Humans; Melanocytes; Melanoma; Nevus; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Skin Neoplasms; Valine | 2012 |
mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma.
Topics: Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glutamic Acid; HEK293 Cells; Humans; Mutation, Missense; Proto-Oncogene Proteins B-raf; Serine; Signal Transduction; Thyroid Cancer, Papillary; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Transfection; Up-Regulation; Valine | 2012 |
Valine but not leucine or isoleucine supports neurotransmitter glutamate synthesis during synaptic activity in cultured cerebellar neurons.
Topics: Animals; Cells, Cultured; Cerebellum; Glutamic Acid; Isoleucine; Leucine; Mice; Neurons; Synaptic Transmission; Valine | 2012 |
Post-acquisition release of glutamate and norepinephrine in the amygdala is involved in taste-aversion memory consolidation.
Topics: Adrenergic beta-Antagonists; Amygdala; Analysis of Variance; Animals; Area Under Curve; Avoidance Learning; Conditioning, Classical; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Lithium Chloride; Male; Memory; Microdialysis; Norepinephrine; Propranolol; Rats; Rats, Wistar; Saccharin; Taste; Valine | 2012 |
Understanding the drug resistance mechanism of hepatitis C virus NS3/4A to ITMN-191 due to R155K, A156V, D168A/E mutations: a computational study.
Topics: Alanine; Amino Acid Substitution; Antiviral Agents; Arginine; Aspartic Acid; Comprehension; Computational Biology; Cyclopropanes; Drug Resistance, Viral; Glutamic Acid; Hepacivirus; Isoindoles; Lactams; Lactams, Macrocyclic; Lysine; Models, Molecular; Molecular Dynamics Simulation; Mutation, Missense; Proline; Sulfonamides; Valine; Viral Nonstructural Proteins | 2012 |
BRAF mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer.
Topics: Aged; Amino Acid Substitution; Biomarkers, Tumor; Cystadenoma, Serous; Early Detection of Cancer; Female; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Middle Aged; Mutation, Missense; Neoplasm Grading; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Proto-Oncogene Proteins B-raf; Survival Analysis; Valine | 2013 |
Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2.
Topics: Acids; Animals; Benzoic Acid; Binding Sites; Biological Transport; Dose-Response Relationship, Drug; Glutamic Acid; HEK293 Cells; Humans; Kidney; Ligands; Liver; Mice; Models, Biological; Organic Anion Transporters, Sodium-Independent; Rats; Substrate Specificity; Time Factors; Valine | 2013 |
Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Benzamides; Blotting, Western; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p21; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, ras; Glutamic Acid; Glycine; Humans; MAP Kinase Signaling System; Melanocytes; Melanoma; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Transcription Factor AP-1; Transfection; Transplantation, Heterologous; Valine; Viral Vaccines | 2012 |
Erdheim-Chester disease harboring the BRAF V600E mutation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Biomarkers; Erdheim-Chester Disease; Glutamic Acid; Humans; Imatinib Mesylate; Immunohistochemistry; Interferon-alpha; Male; Middle Aged; Mutation; Piperazines; Prednisolone; Proto-Oncogene Proteins B-raf; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Valine | 2012 |
The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Cohort Studies; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Male; Middle Aged; Mutation, Missense; Prognosis; Proto-Oncogene Proteins B-raf; Risk Factors; Sample Size; Thyroid Cancer, Papillary; Thyroid Gland; Thyroid Neoplasms; Valine; Young Adult | 2012 |
Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Glutamic Acid; Male; Miniature Postsynaptic Potentials; Neuromuscular Junction; Neuronal Plasticity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Paraoxon; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Valine | 2013 |
Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biophysics; Biotinylation; Cells, Cultured; Colforsin; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Flow Cytometry; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Indoles; Kainic Acid; Long-Term Potentiation; Male; Neurons; Protein Transport; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Valine | 2012 |
BRAF (V600E) associates with cytoplasmatic localization of p27kip1 and higher cytokeratin 19 expression in papillary thyroid carcinoma.
Topics: Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Galectin 3; Gene Expression Regulation, Neoplastic; Gene Frequency; Glutamic Acid; Humans; Immunohistochemistry; Keratin-19; Proto-Oncogene Proteins B-raf; Thyroid Cancer, Papillary; Thyroid Neoplasms; Valine | 2013 |
Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation.
Topics: Adult; Aged; Amino Acid Substitution; Anti-Inflammatory Agents; Drug Resistance; Erdheim-Chester Disease; Female; Glutamic Acid; Histiocytosis, Langerhans-Cell; Humans; Indoles; Male; Middle Aged; Mutation, Missense; Proto-Oncogene Proteins B-raf; Sulfonamides; Treatment Outcome; Valine; Vemurafenib | 2013 |
Involvement of NMDA receptors in nicotine-mediated central control of hypotensive effects.
Topics: Animals; Blood Pressure; Bradycardia; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hypotension; Male; Nicotine; Nicotinic Agonists; Quinoxalines; Rats; Rats, Inbred WKY; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Solitary Nucleus; Valine | 2012 |
Amino acid turnover by human oocytes is influenced by gamete developmental competence, patient characteristics and gonadotrophin treatment.
Topics: Age Factors; Alanine; Amino Acids; Arginine; Chorionic Gonadotropin; Chromatography, High Pressure Liquid; Female; Follicle Stimulating Hormone; Glutamic Acid; Glutamine; Gonadotropins; Humans; Infertility, Female; Isoleucine; Kinetics; Lysine; Metaphase; Oocytes; Ovulation Induction; Polycystic Ovary Syndrome; Serine; Valine | 2013 |
Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression.
Topics: Adolescent; Antigens, CD34; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Female; Ganglioglioma; Glutamic Acid; Humans; Infant; Male; Neoplasms, Neuroepithelial; Proto-Oncogene Proteins B-raf; Valine; Young Adult | 2013 |
Does addition of BRAF V600E mutation testing modify sensitivity or specificity of the Afirma Gene Expression Classifier in cytologically indeterminate thyroid nodules?
Topics: Amino Acid Substitution; Biopsy, Fine-Needle; Cytological Techniques; Diagnosis, Differential; DNA Mutational Analysis; Gene Expression Profiling; Genetic Testing; Glutamic Acid; HT29 Cells; Humans; Mutation, Missense; Proto-Oncogene Proteins B-raf; Reproducibility of Results; Sensitivity and Specificity; Thyroid Nodule; Valine | 2013 |
BRAF V600E mutation identifies a subset of low-grade diffusely infiltrating gliomas in adults.
Topics: Adult; Astrocytoma; Brain Neoplasms; Female; Glioma; Glutamic Acid; Humans; Immunohistochemistry; Male; Neoplasm Grading; Point Mutation; Proto-Oncogene Proteins B-raf; Valine | 2013 |
Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Area Under Curve; Aza Compounds; Chromatography, High Pressure Liquid; Dopamine; Efferent Pathways; Excitatory Amino Acid Antagonists; Glutamic Acid; Heterocyclic Compounds, 4 or More Rings; Hormone Antagonists; Male; Microdialysis; Mifepristone; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Stress, Physiological; Tail; Valine; Ventral Tegmental Area | 2013 |
[Use of BRAF V600E mutation in the differential diagnosis of follicular and papillary tumors of the thyroid and for the optimization of thearpy].
Topics: Adenocarcinoma, Follicular; Adult; Biopsy, Fine-Needle; Carcinoma, Papillary; Diagnosis, Differential; Female; Glutamic Acid; Goiter; Humans; Male; Middle Aged; Mutation; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Thyroid Neoplasms; Valine | 2012 |
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.
Topics: Animals; Bacterial Proteins; Channelrhodopsins; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hypothalamus; In Vitro Techniques; Light; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neural Pathways; Neurotensin; Pyrazoles; Quinolines; Quinoxalines; Receptors, Neurotensin; Reward; Self Stimulation; Signal Transduction; Tyrosine 3-Monooxygenase; Valine; Ventral Tegmental Area | 2013 |
Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Drug Resistance, Neoplasm; Flow Cytometry; Glutamic Acid; Humans; Indoles; Induction Chemotherapy; Leukemia, Hairy Cell; Male; Middle Aged; Molecular Targeted Therapy; Point Mutation; Proto-Oncogene Proteins B-raf; Rituximab; Sulfonamides; Treatment Outcome; Valine; Vemurafenib | 2013 |
Erythema nodosum-like panniculitis in patients with melanoma treated with vemurafenib.
Topics: Adult; Antineoplastic Agents; Diagnosis, Differential; Erythema Nodosum; Female; Glutamic Acid; Humans; Indoles; Male; Melanoma; Middle Aged; Molecular Targeted Therapy; Panniculitis; Point Mutation; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Valine; Vemurafenib | 2013 |
Crystal structure of α-1,4-glucan lyase, a unique glycoside hydrolase family member with a novel catalytic mechanism.
Topics: Acarbose; alpha-Glucosidases; Catalysis; Catalytic Domain; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Glucans; Glutamic Acid; Glycoside Hydrolases; Mutagenesis, Site-Directed; Mutation; Polysaccharide-Lyases; Protein Structure, Tertiary; Protons; Seaweed; Sulfolobus solfataricus; Trisaccharides; Valine | 2013 |
Potassium channels control the interaction between active dendritic integration compartments in layer 5 cortical pyramidal neurons.
Topics: Alkaloids; Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Signaling; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Indoles; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Potassium Channels; Probability; Pyramidal Cells; Quinolines; Rats; Rats, Wistar; Somatosensory Cortex; Time Factors; Valine | 2013 |
Cholinergic modulation of primary afferent glutamatergic transmission in rat medullary dorsal horn neurons.
Topics: Acetylcholine; Anesthetics, Local; Animals; Animals, Newborn; Cholinergic Agents; Drug Interactions; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Male; Medulla Oblongata; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Synaptic Transmission; Tetrodotoxin; Valine | 2013 |
Copper chelation and exogenous copper affect circadian clock phase resetting in the suprachiasmatic nucleus in vitro.
Topics: Animals; Carbazoles; Chelating Agents; Circadian Clocks; Copper; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Indole Alkaloids; Male; Mice; Mice, Inbred C57BL; Molybdenum; Phenanthrolines; Quinoxalines; Suprachiasmatic Nucleus; Valine | 2014 |
Absent response of intracranial melanoma metastases harboring BRAF V600E sequence variation to vemurafenib.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Fatal Outcome; Glutamic Acid; Humans; Ileal Neoplasms; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Male; Melanoma; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Treatment Failure; Valine; Vemurafenib | 2013 |
Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Asian People; Aspartic Acid; Female; Genetic Predisposition to Disease; Germ-Line Mutation; Glutamic Acid; Glycine; Humans; Japan; Lung Neoplasms; Male; Middle Aged; Pedigree; Receptor, ErbB-2; Valine | 2014 |
Intratumoral heterogeneity of genomic imbalance in a case of epithelioid glioblastoma with BRAF V600E mutation.
Topics: Brain Neoplasms; DNA Mutational Analysis; Glioblastoma; Glutamic Acid; Humans; Isocitrate Dehydrogenase; Male; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins B-raf; Valine; Young Adult | 2014 |
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota.
Topics: Adolescent; Cell Transformation, Neoplastic; Glutamic Acid; Humans; Male; Melanocytes; Melanoma; Meningeal Neoplasms; Mutation; Nevus of Ota; Proto-Oncogene Proteins B-raf; Signal Transduction; Skin Neoplasms; Valine | 2014 |
TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer.
Topics: Adenocarcinoma, Follicular; Adult; Aged; Amino Acid Substitution; Base Sequence; Carcinoma; Carcinoma, Papillary; Cohort Studies; Female; Gene Frequency; Genetic Association Studies; Glutamic Acid; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation; Neoplasm Invasiveness; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Telomerase; Thyroid Cancer, Papillary; Thyroid Neoplasms; Valine | 2014 |
High-sensitivity BRAF mutation analysis: BRAF V600E is acquired early during tumor development but is heterogeneously distributed in a subset of papillary thyroid carcinomas.
Topics: Adult; Aged; Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Cell Transformation, Neoplastic; DNA Mutational Analysis; Gene Frequency; Genetic Heterogeneity; Glutamic Acid; Humans; Middle Aged; Polymerase Chain Reaction; Proto-Oncogene Proteins B-raf; Thyroid Cancer, Papillary; Thyroid Neoplasms; Valine; Young Adult | 2014 |
Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation.
Topics: Amino Acid Substitution; Astrocytoma; Brain Neoplasms; Child; Female; Glioblastoma; Glutamic Acid; Humans; Magnetic Resonance Imaging; Mutation; Neoplasms, Second Primary; Proto-Oncogene Proteins B-raf; Time Factors; Valine | 2014 |
Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.
Topics: Adult; Aged; Aspartic Acid; Clinical Trials, Phase III as Topic; Colonic Neoplasms; DNA Mismatch Repair; Female; Glutamic Acid; Glycine; Humans; Logistic Models; Male; Middle Aged; Molecular Epidemiology; Mutation; Neoplasm Grading; Prospective Studies; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); ras Proteins; Surveys and Questionnaires; Valine | 2014 |
Electrophysiological characterization of methyleugenol: a novel agonist of GABA(A) receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Eugenol; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; GABA Agents; GABA-A Receptor Agonists; Glutamic Acid; Glycine; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Valine | 2014 |
High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis.
Topics: Amino Acid Substitution; Female; Gene Frequency; Genetic Predisposition to Disease; Glutamic Acid; Histiocytosis, Langerhans-Cell; Humans; Male; MAP Kinase Kinase 1; Mutation, Missense; Prevalence; Proto-Oncogene Proteins B-raf; Retrospective Studies; Valine | 2014 |
A hybrid electrical/chemical circuit in the spinal cord generates a transient embryonic motor behavior.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Genetically Modified; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electric Stimulation; Embryo, Nonmammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; Green Fluorescent Proteins; Motor Activity; Motor Neurons; Nerve Net; Neural Pathways; Rhombencephalon; Spinal Cord; Synapses; Transcription Factors; Valine; Zebrafish; Zebrafish Proteins | 2014 |
Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.
Topics: Angiogenesis Inhibitors; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Genotype; Glutamic Acid; Hemangiopericytoma; Humans; Indoles; Mass Spectrometry; Mutation; Neoplasm Recurrence, Local; Pericytes; Proto-Oncogene Proteins B-raf; Sulfonamides; Thyroid Neoplasms; Valine; Vemurafenib; Xenograft Model Antitumor Assays | 2014 |
Successful Treatment of a Progressive BRAF V600E-Mutated Anaplastic Pleomorphic Xanthoastrocytoma With Vemurafenib Monotherapy.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Drug Administration Schedule; Drug Eruptions; Frontal Lobe; Glutamic Acid; Humans; Indoles; Magnetic Resonance Imaging; Male; Mutation; Neoplasm Staging; Proto-Oncogene Proteins B-raf; Sulfonamides; Temporal Lobe; Treatment Outcome; Valine; Vemurafenib; Xanthomatosis | 2016 |
Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition.
Topics: Amino Acid Substitution; Cell Proliferation; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Glutamic Acid; Humans; Indoles; Melanoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sulfonamides; Tumor Cells, Cultured; Valine; Vemurafenib | 2014 |
A mechanistic study on urine retention in d-amphetamine addicts.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Amidines; Amphetamine-Related Disorders; Animals; Benzophenanthridines; Central Nervous System Stimulants; Chronic Disease; Colforsin; Dextroamphetamine; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Isoquinolines; N-Methylaspartate; Oxidants; Protein Kinase Inhibitors; Rats, Wistar; Reflex; Spinal Cord; Sulfonamides; Urinary Retention; Urination; Valine | 2014 |
Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma.
Topics: Adult; Ameloblastoma; Antineoplastic Combined Chemotherapy Protocols; Black or African American; Compassionate Use Trials; Glutamic Acid; Humans; Imidazoles; Lung Neoplasms; Male; Mandibular Neoplasms; Molecular Targeted Therapy; Mutation; Neoplasm Recurrence, Local; Neoplasm Staging; Oximes; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Radiography; Treatment Outcome; Valine | 2015 |
Association of TERT promoter mutation 1,295,228 C>T with BRAF V600E mutation, older patient age, and distant metastasis in anaplastic thyroid cancer.
Topics: Age Factors; Aged; Aged, 80 and over; Amino Acid Substitution; Epistasis, Genetic; Female; Genetic Association Studies; Glutamic Acid; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Telomerase; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Valine | 2015 |
Stimulation of glutamate receptors in the ventral tegmental area is necessary for serotonin-2 receptor-induced increases in mesocortical dopamine release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amphetamines; Animals; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; N-Methylaspartate; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Serotonin, 5-HT2; Serotonin 5-HT2 Receptor Agonists; Valine; Ventral Tegmental Area | 2015 |
S-Isovaline Contained in Meteorites, Induces Enantiomeric Excess in D,L-glutamic Acid During Recrystallization.
Topics: Asparagine; Chromatography, High Pressure Liquid; Crystallization; Evolution, Chemical; Glutamic Acid; Leucine; Meteoroids; Nitro Compounds; Stereoisomerism; Valine | 2015 |
Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Amygdaloid Nucleus; Conditioning, Classical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extinction, Psychological; Fear; Glutamic Acid; In Vitro Techniques; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Methylaspartate; Neurons; Piperidines; Polymorphism, Single Nucleotide; Synapses; Valine | 2015 |
A novel lamin A/C gene missense mutation (445 V > E) in immunoglobulin-like fold associated with left ventricular non-compaction.
Topics: Adolescent; Death, Sudden, Cardiac; DNA Mutational Analysis; Echocardiography; Electrocardiography; Genetic Predisposition to Disease; Glutamic Acid; HEK293 Cells; Heterozygote; Humans; Isolated Noncompaction of the Ventricular Myocardium; Lamin Type A; Male; Membrane Potentials; Microscopy, Fluorescence; Models, Molecular; Mutagenesis, Site-Directed; Mutation, Missense; Phenotype; Protein Aggregates; Protein Conformation, beta-Strand; Protein Folding; Structure-Activity Relationship; Tachycardia, Ventricular; Transfection; Valine; Ventricular Fibrillation; Young Adult | 2016 |
A tripeptide isolated from Bothrops atrox venom has neuroprotective and neurotrophic effects on a cellular model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Bothrops; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dopamine; Dopaminergic Neurons; Glutamic Acid; Mitochondria; Models, Biological; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Peptides; Rats; Tryptophan; Valine; Venoms | 2015 |
Insight into the role of alternative splicing within the RBM10v1 exon 10 tandem donor site.
Topics: Alternative Splicing; Cell Line, Tumor; Exons; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Lung Neoplasms; Male; Membrane Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Nucleotide Motifs; Point Mutation; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Small Cell Lung Carcinoma; Valine | 2015 |
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Dendritic Spines; Dizocilpine Maleate; Egtazic Acid; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Valine | 2015 |
The Risk of Relapse in Papillary Thyroid Cancer (PTC) in the Context of BRAFV600E Mutation Status and Other Prognostic Factors.
Topics: Adult; Amino Acid Substitution; Biomarkers, Tumor; Carcinoma; Carcinoma, Papillary; Female; Gene Frequency; Glutamic Acid; Humans; Male; Middle Aged; Mutation, Missense; Predictive Value of Tests; Prognosis; Proto-Oncogene Proteins B-raf; Recurrence; Risk Factors; Thyroid Cancer, Papillary; Thyroid Neoplasms; Valine | 2015 |
The mesencephalic locomotor region sends a bilateral glutamatergic drive to hindbrain reticulospinal neurons in a tetrapod.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Stem; Calcium; Cell Count; Choline O-Acetyltransferase; Dextrans; Electric Stimulation; Excitatory Amino Acid Antagonists; Female; Functional Laterality; Glutamic Acid; In Vitro Techniques; Locomotion; Male; Neurons, Afferent; Urodela; Valine | 2016 |
Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Craniopharyngioma; Craniotomy; Cytoreduction Surgical Procedures; Drug Administration Schedule; Glutamic Acid; Humans; Imidazoles; Magnetic Resonance Imaging; Male; Molecular Targeted Therapy; Mutation; Neoplasm Recurrence, Local; Neoplasm, Residual; Oximes; Pituitary Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Treatment Outcome; Valine | 2016 |
Relationships between transporter expression and the status of BRAF V600E mutation and F-18 FDG uptake in papillary thyroid carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Female; Fluorodeoxyglucose F18; Glucose Transporter Type 1; Glucose Transporter Type 3; Glutamic Acid; Humans; Immunohistochemistry; Male; Middle Aged; Mutation, Missense; Positron-Emission Tomography; Proto-Oncogene Proteins B-raf; Retrospective Studies; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tomography, Emission-Computed; Valine; Young Adult | 2016 |
Chronic lymphocytic thyroiditis and BRAF V600E in papillary thyroid carcinoma.
Topics: Adult; Amino Acid Substitution; Carcinoma; Carcinoma, Papillary; Female; Glutamic Acid; Hashimoto Disease; Humans; Lymphatic Metastasis; Male; Middle Aged; Mutation, Missense; Prognosis; Proto-Oncogene Proteins B-raf; Retrospective Studies; Thyroid Cancer, Papillary; Thyroid Neoplasms; Valine | 2016 |
Recurrent ganglioglioma in adults treated with BRAF inhibitors.
Topics: Adult; Brain Neoplasms; Enzyme Inhibitors; Female; Ganglioglioma; Glutamic Acid; Humans; Imidazoles; Male; Middle Aged; Mutation; Oximes; Proto-Oncogene Proteins B-raf; Valine | 2016 |
BRAF inhibition for advanced locoregional BRAF V600E mutant melanoma: a potential neoadjuvant strategy.
Topics: Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Female; Follow-Up Studies; Glutamic Acid; Humans; Imidazoles; Indoles; Male; Melanoma; Middle Aged; Molecular Targeted Therapy; Mutation, Missense; Neoadjuvant Therapy; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Retrospective Studies; Skin Neoplasms; Sulfonamides; Treatment Outcome; Valine; Vemurafenib | 2016 |
Molecular targeting of papillary thyroid carcinoma with fluorescently labeled ratiometric activatable cell penetrating peptides in a transgenic murine model.
Topics: Animals; Animals, Genetically Modified; Carcinoma; Carcinoma, Papillary; Cell-Penetrating Peptides; Disease Models, Animal; Fluorescence; Glutamic Acid; Laryngoscopy; Larynx; Mice; Molecular Targeted Therapy; Proto-Oncogene Proteins B-raf; Staining and Labeling; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroidectomy; Treatment Outcome; Valine; Video Recording; Vocal Cords | 2016 |
Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Immunohistochemistry; Interferon-alpha; MAP Kinase Signaling System; Melanoma; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Proto-Oncogene Proteins B-raf; Receptor, Interferon alpha-beta; Signal Transduction; Skin Neoplasms; Valine | 2016 |
Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.
Topics: Algorithms; Animals; Arginine; Cardiomyopathy, Hypertrophic; Computational Biology; Gene Expression Profiling; Gene Expression Regulation; Glutamic Acid; Glutamine; Lysine; Mice; Mice, Transgenic; Multigene Family; Mutation; Myocardium; Myosin Light Chains; Oligonucleotide Array Sequence Analysis; Phenotype; Principal Component Analysis; Valine | 2016 |
A novel multi-biofunctional protein from brown rice hydrolysed by endo/endo-exoproteases.
Topics: Adult; Aspartic Acid; Chemical Phenomena; Endopeptidases; Exopeptidases; Female; Glutamic Acid; Glycine; Guanosine Monophosphate; Humans; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Inosine Monophosphate; Leucine; Male; Molecular Weight; Oryza; Plant Proteins; Sodium Glutamate; Taste; Valine; Volatile Organic Compounds | 2016 |
Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation.
Topics: Adolescent; Astrocytoma; Brain Neoplasms; DNA Helicases; Exons; Female; Glutamic Acid; Humans; Male; Mitogen-Activated Protein Kinase Kinases; Mutation; Nuclear Proteins; Nuclear Respiratory Factor 1; Oncogene Fusion; Proto-Oncogene Proteins B-raf; raf Kinases; Signal Transduction; Time Factors; Transcription Factors; Tripartite Motif-Containing Protein 28; Tumor Suppressor Protein p53; Valine; World Health Organization; Young Adult | 2016 |
Chemical Mechanism of the Branched-Chain Aminotransferase IlvE from Mycobacterium tuberculosis.
Topics: Bacterial Proteins; Biocatalysis; Biosynthetic Pathways; Catalytic Domain; Glutamic Acid; Hydrogen-Ion Concentration; Isoleucine; Kinetics; Leucine; Lysine; Models, Chemical; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Protein Conformation; Pyridoxal Phosphate; Transaminases; Valine | 2016 |
Translation-dependent bioassay for amino acid quantification using auxotrophic microbes as biocatalysts of protein synthesis.
Topics: beta-Galactosidase; Biological Assay; Calibration; Colorimetry; Genes, Reporter; Glutamic Acid; Glutamine; Green Fluorescent Proteins; Histidine; Lactococcus lactis; Luciferases; Protein Biosynthesis; Sensitivity and Specificity; Spectrometry, Fluorescence; Time Factors; Valine | 2017 |
Memory trace reactivation and behavioral response during retrieval are differentially modulated by amygdalar glutamate receptors activity: interaction between amygdala and insular cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Analysis of Variance; Animals; Avoidance Learning; Cerebral Cortex; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mental Recall; Neural Pathways; Norepinephrine; Rats; Rats, Wistar; Receptors, Glutamate; Taste; Valine | 2017 |
BRAF V600E mutation in epilepsy-associated glioneuronal tumors: Prevalence and correlation with clinical features in a Chinese population.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Child; Child, Preschool; China; Cohort Studies; Electroencephalography; Epilepsy; Female; Glioma; Glutamic Acid; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins B-raf; Statistics as Topic; Statistics, Nonparametric; Valine; Young Adult | 2017 |
Charges in Hydrophobic Environments: A Strategy for Identifying Alternative States in Proteins.
Topics: Crystallization; Crystallography, X-Ray; Glutamic Acid; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Magnetic Resonance Spectroscopy; Micrococcal Nuclease; Models, Molecular; Mutation, Missense; Protein Conformation; Protein Structure, Secondary; Staphylococcus aureus; Static Electricity; Thermodynamics; Valine; Water | 2017 |
Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain.
Topics: Gene Expression Regulation, Fungal; Glutamic Acid; Glutamine; HSP70 Heat-Shock Proteins; Isoleucine; Kinetics; Leucine-tRNA Ligase; Proline; Protein Folding; Reactive Oxygen Species; RNA Editing; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stress, Physiological; Valine | 2017 |
Flipping states: a few key residues decide the winning conformation of the only universally conserved transcription factor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; DNA-Directed RNA Polymerases; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Evolution, Molecular; Gene Expression Regulation, Bacterial; Glutamic Acid; Isoleucine; Models, Molecular; Peptide Elongation Factors; Phenylalanine; Protein Binding; Protein Folding; Protein Interaction Domains and Motifs; Sequence Alignment; Sequence Homology, Amino Acid; Trans-Activators; Transcription Factors; Transcription, Genetic; Valine | 2017 |
A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Experimental; Excitatory Amino Acid Antagonists; Gene Knockdown Techniques; Glutamic Acid; Heart Rate; Hypothalamus; Kidney; Leptin; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Leptin; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Sympathetic Nervous System; Valine | 2017 |
The Effects of One Amino Acid Substitutions at the C-Terminal Region of Thermostable L2 Lipase by Computational and Experimental Approach.
Topics: Amino Acid Substitution; Bacterial Proteins; Circular Dichroism; Enzyme Stability; Glutamic Acid; Isoleucine; Lipase; Molecular Dynamics Simulation; Protein Conformation; Recombinant Proteins; Serine; Temperature; Valine | 2018 |
Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Cells, Cultured; DNA Methylation; Epigenesis, Genetic; Epilepsy; Excitatory Amino Acid Agents; Gene Expression; Glutamic Acid; Hippocampus; Microtubule-Associated Proteins; Models, Biological; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin; Valine | 2017 |
Kainate receptor mediated presynaptic LTP in agranular insular cortex contributes to fear and anxiety in mice.
Topics: Animals; Anxiety; Cerebral Cortex; Conditioning, Classical; Disease Models, Animal; Disks Large Homolog 4 Protein; Excitatory Amino Acid Agents; Exploratory Behavior; Fear; Glutamic Acid; Long-Term Potentiation; Male; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Receptors, Kainic Acid; Synaptosomal-Associated Protein 25; Valine | 2018 |
The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Learning; Long-Term Potentiation; Long-Term Synaptic Depression; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Peptide Fragments; Protein Domains; Quinoxalines; Receptors, AMPA; Sodium Channel Blockers; Synapses; Tetrodotoxin; Valine | 2018 |
Pathological progression of genetic Creutzfeldt-Jakob disease with a PrP V180I mutation.
Topics: Aged; Aged, 80 and over; Brain; Creutzfeldt-Jakob Syndrome; Disease Progression; Gliosis; Glutamic Acid; Humans; Isoleucine; Methionine; Middle Aged; Mutation; Prion Proteins; Vacuoles; Valine | 2018 |
Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers.
Topics: Amino Acid Substitution; Animals; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Glutamic Acid; HT29 Cells; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Mutant Proteins; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured; Valine; Xenograft Model Antitumor Assays | 2018 |
BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma.
Topics: Astrocytoma; Brain Neoplasms; Child, Preschool; Glutamic Acid; Humans; Male; Mutation; Proto-Oncogene Proteins B-raf; Valine; Young Adult | 2018 |
Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain.
Topics: Action Potentials; Animals; Animals, Newborn; Channelrhodopsins; Disease Models, Animal; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Hippocampus; Male; Nerve Net; Neural Inhibition; Neural Pathways; Neuralgia; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Thalamus; Valine | 2018 |
Degradable 3D-Printed Hydrogels Based on Star-Shaped Copolypeptides.
Topics: 3T3 Cells; Animals; Biodegradable Plastics; Glutamic Acid; Hydrogels; Hydrophobic and Hydrophilic Interactions; Mice; Peptides; Printing, Three-Dimensional; Valine | 2018 |
Glutamic acid-valine-citrulline linkers ensure stability and efficacy of antibody-drug conjugates in mice.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Breast Neoplasms; Carboxylic Ester Hydrolases; Cell Line, Tumor; Citrulline; Drug Design; Drug Stability; Female; Gene Expression; Glutamic Acid; Humans; Hydrolysis; Immunoconjugates; Mice; Mice, Inbred BALB C; Mice, Nude; Oligopeptides; Receptor, ErbB-2; Survival Analysis; Valine; Xenograft Model Antitumor Assays | 2018 |
One Step up the Ladder of Prebiotic Complexity: Formation of Nonrandom Linear Polypeptides from Binary Systems of Amino Acids on Silica.
Topics: Amino Acids; Aspartic Acid; Glutamic Acid; Leucine; Peptides; Polymerization; Prebiotics; Silicon Dioxide; Spectrometry, Mass, Electrospray Ionization; Thermogravimetry; Valine | 2019 |
Seminal plasma amino acid profile in different breeds of chicken: Role of seminal plasma on sperm cryoresistance.
Topics: Alanine; Amino Acids; Animals; Chickens; Cryopreservation; DNA Fragmentation; Glutamic Acid; Glycine; In Situ Nick-End Labeling; Male; Semen; Serine; Spermatozoa; Valine | 2019 |
Cytotoxicity and mitochondrial dysfunction caused by the dietary supplement l-norvaline.
Topics: Apoptosis; Calcium; Cell Line, Tumor; Cell Survival; Dietary Supplements; Glutamic Acid; Humans; Mitochondria; Oxygen Consumption; Valine | 2019 |
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine | 2019 |
Identification of serological markers for pre- and postoperative fasting periods.
Topics: Biomarkers; Elective Surgical Procedures; Fasting; Female; Gastrointestinal Diseases; Glutamic Acid; Humans; Male; Middle Aged; Nutritional Status; Nutritional Support; Predictive Value of Tests; Preoperative Period; Prospective Studies; Valine | 2019 |
Electrical stimulation mPFC affects morphine addiction by changing glutamate concentration in the ventral tegmental area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Morphine; Morphine Dependence; Narcotics; Prefrontal Cortex; Rats; Rats, Wistar; Valine; Ventral Tegmental Area | 2019 |
Revisiting the role of autophagy in melanoma.
Topics: Amino Acid Substitution; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Glutamic Acid; Humans; MAP Kinase Signaling System; Melanoma; Proto-Oncogene Proteins B-raf; Signal Transduction; Skin Neoplasms; Valine | 2019 |
Evaluation of the liquid biopsy for the detection of BRAFV600E mutation in metastatic melanoma patients.
Topics: Amino Acid Substitution; Biomarkers, Tumor; Circulating Tumor DNA; DNA Mutational Analysis; Feasibility Studies; Glutamic Acid; Humans; Liquid Biopsy; Melanoma; Mutation; Neoplastic Cells, Circulating; Proto-Oncogene Proteins B-raf; Real-Time Polymerase Chain Reaction; Skin Neoplasms; Valine | 2019 |
New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAFV600E mutation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Autophagy; Child; Female; Glutamic Acid; Humans; Immunohistochemistry; Intranuclear Inclusion Bodies; Male; Middle Aged; Mutation, Missense; Proto-Oncogene Proteins B-raf; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tissue Array Analysis; Valine; Young Adult | 2019 |
Functional Analysis of the SIM1 Variant p.G715V in 2 Patients With Obesity.
Topics: Adult; Amino Acid Substitution; Basic Helix-Loop-Helix Transcription Factors; Genetic Association Studies; Glutamic Acid; Humans; Male; Middle Aged; Mutation, Missense; Obesity; Prader-Willi Syndrome; Repressor Proteins; Valine | 2020 |
Pre-mounted dry TAVI valve with improved endothelialization potential using REDV-loaded PEGMA hydrogel hybrid pericardium.
Topics: Animals; Arginine; Aspartic Acid; Cells, Cultured; Glutamic Acid; Humans; Hydrogels; Male; Materials Testing; Methacrylates; Molecular Structure; Particle Size; Pericardium; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Surface Properties; Transcatheter Aortic Valve Replacement; Valine | 2020 |
Molecular Profiling of Follicular Variant of Papillary Thyroid Cancer.
Topics: Adult; Amino Acid Substitution; Carcinoma, Papillary, Follicular; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Male; Middle Aged; Mutation, Missense; Proto-Oncogene Proteins B-raf; Signal Transduction; Thyroid Neoplasms; Valine | 2020 |
BRAF V600E and TERT promoter mutations in paediatric and young adult papillary thyroid cancer and clinicopathological correlation.
Topics: Adolescent; Adult; Age of Onset; Amino Acid Substitution; DNA Mutational Analysis; Female; Glutamic Acid; Humans; India; Male; Mutation, Missense; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Telomerase; Thyroid Cancer, Papillary; Thyroid Neoplasms; Valine; Young Adult | 2020 |
Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma.
Topics: Adolescent; Age of Onset; Amino Acid Substitution; Child; Colombia; Female; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Incidence; Male; Mutation, Missense; Prognosis; Proto-Oncogene Proteins B-raf; Symporters; Thyroid Cancer, Papillary; Thyroid Neoplasms; Thyroidectomy; Treatment Outcome; Valine | 2020 |
Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes.
Topics: Adult; Aged; Betaine; Biomarkers; Carnitine; Case-Control Studies; Diabetes Mellitus, Type 2; Early Diagnosis; Female; Genetic Predisposition to Disease; Glutamic Acid; Humans; Leucine; Lysine; Male; Mannose; Mendelian Randomization Analysis; Metabolome; Middle Aged; Valine | 2021 |
Molecular Insight into the β-Sheet Twist and Related Morphology of Self-Assembled Peptide Amphiphile Ribbons.
Topics: Glutamic Acid; Peptides; Protein Conformation, beta-Strand; Surface-Active Agents; Valine | 2021 |
An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer.
Topics: Animals; Arginine; Breast Neoplasms; Choline; Female; Glutamic Acid; Histidine; Humans; Isoleucine; Lactic Acid; Leucine; Lung Neoplasms; Metabolomics; Mice; Taurine; Valine | 2022 |
Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites.
Topics: Alanine; Ammonia; Antifungal Agents; Arginine; Aspartic Acid; Bacillus subtilis; Biotransformation; Carbon; Fusarium; Glutamic Acid; Glutamine; Glycine; Isoleucine; Leucine; Linoleic Acids; Linolenic Acids; Microarray Analysis; Nitrogen; Phenotype; Plant Diseases; Proline; RNA, Transfer; Solanum lycopersicum; Valine | 2022 |
Toxicity effects of chlorantraniliprole in zebrafish (Danio rerio) involving in liver function and metabolic phenotype.
Topics: Alanine; Animals; Aspartic Acid; Glutamic Acid; Glutamine; Insecticides; Isoleucine; Leucine; Liver; Malondialdehyde; ortho-Aminobenzoates; Phenotype; Valine; Water Pollutants, Chemical; Zebrafish | 2022 |
Comparison of amino acid digestibility and its additivity determined with slaughter or cecectomy method for yellow-feather chicken.
Topics: Amino Acids; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Aspartic Acid; Chickens; Diet; Digestion; Feathers; Glutamic Acid; Glycine; Glycine max; Histidine; Ileum; Isoleucine; Leucine; Lysine; Methionine; Phenylalanine; Valine; Zea mays | 2022 |
Metabolomics profiling of seminal plasma in obesity-induced asthenozoospermia.
Topics: Aconitic Acid; Alanine; Asthenozoospermia; Citrulline; Glucose; Glutamic Acid; Glycine; Humans; Leucine; Lysine; Male; Metabolomics; Phenylalanine; Proline; Semen; Serine; Succinic Acid; Threonine; Tyrosine; Valine | 2023 |
The Association between Macrosomia and Amino Acids' Levels in Maternal and Cord Sera: A Case-Control Study.
Topics: Alanine; Amino Acids; Arginine; Case-Control Studies; Chromatography, Liquid; Female; Fetal Macrosomia; Glutamic Acid; Glutamine; Histidine; Humans; Infant, Newborn; Leucine; Methionine; Tandem Mass Spectrometry; Threonine; Tryptophan; Valine | 2023 |