valine and fumarates

valine has been researched along with fumarates in 63 studies

Research

Studies (63)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (9.52)	18.7374
1990's	0 (0.00)	18.2507
2000's	19 (30.16)	29.6817
2010's	38 (60.32)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Matrone, G; Schwarz, FJ	1
Spydevold, O	1
Erfle, JD; Mahadevan, S; Sauer, FD	1
Nakamura, M; Nakata, T; Nose, Y	1
De Gasquet, P; Krebs, HA	1
Orlova, IG; Shaposhnikov, VN	1
Takahashi, N; Yamada, T	1
Azizi, M; Bissery, A; Bura-Rivière, A; Camisasca, RP; Guyenne, TT; Ménard, J; Vaidyanathan, S	1
Cumin, F; Menard, J; Schnell, CR; Webb, RL; Wood, JM	1
Dechend, R; Feldman, DL; Fiebeler, A; Garrelds, IM; Gratze, P; Jan Danser, AH; Luft, FC; Meiners, S; Müller, DN; Pilz, B; Shagdarsuren, E; Webb, RL; Wellner, M	1
Azizi, M; Guyene, TT; Ménard, J; Peyrard, S	1
Bizot, MN; Denouel, J; Dieterich, HA; Dole, WP; Kemp, C; Vaidyanathan, S; Valencia, J; Yeh, CM; Zhao, C	1
Aldigier, JC; Azizi, M; Chiang, Y; Januszewicz, A; Pool, JL; Satlin, A; Schmieder, RE; Zidek, W	1
Birkenhäger, WH; Staessen, JA	1
Fang, H; Oparil, S; Patel, S; Satlin, A; Yarows, SA; Zhang, J	1
Azizi, M; Bissery, A; Bura-Rivière, A; Guyene, TT; Ménard, J	1
Ashiya, M; Smith, RE	1
Oparil, S; Patel, S; Satlin, A; Yarows, SA; Zhang, J	1
Deswal, A; Mann, DL; Ramasubbu, K	1
Chrysant, SG; Dattani, D; Hoppe, UC; Hsu, H; Murray, AV; Patel, S; Zhang, J	1
Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kitabata, H; Kuroi, A; Mochizuki, S; Muragaki, Y; Takarada, S; Tanimoto, T; Tsujioka, H; Yoshida, K	1
Fang, H; Oparil, S; Patel, S; Yarows, SA; Zhang, J	1
Barranco, E; Geiger, H; Gorostidi, M; Taylor, A; Xiang, Z; Zhang, J; Zhang, X	1
Dong, YF; Fukuda, M; Kaneko, T; Kataoka, K; Kim-Mitsuyama, S; Matsuba, S; Nakagata, N; Nakamura, T; Nako, H; Ogawa, H; Tokutomi, Y; Yamamoto, E	1
Yarows, SA	1
Dong, YF; Fukuda, M; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Liu, L; Nakamura, T; Nako, H; Ogawa, H; Tokutomi, Y; Yamamoto, E	1
Suzuki, H; Takenaka, T	1
Chrysant, SG	2
Bode, C; Braunwald, E; Cannon, CP; Lopez-Sendon, J; Lukashevich, V; Maboudian, M; McCabe, CH; Morrow, DA; Ogorek, M; Oude Ophuis, AJ; Rifai, N; Ruda, M; Ruzyllo, W; Scirica, BM; Swedberg, K	1
Chang, CH; Chiu, YT; Ku, CL; Shu, KH; Wen, MC; Wu, MJ; Wu, WP	1
Epstein, BJ	1
Chrysant, SG; Dattani, D; Hoppe, UC; Murray, AV; Patel, S; Ritter, S; Zhang, J	1
Derbentseva, EA; Dralova, OV; Ermolaeva, AS; Maksimov, ML; Starodubtsev, AK	1
Higashikuni, Y; Hirata, Y; Iwata, H; Nagai, R; Sata, M; Takaoka, M; Tanaka, K	1
Birnbaum, Y; Castillo, AC; Perez-Polo, JR; Qian, J; Ye, Y	1
Ahmad, S; Ferrario, CM; Moniwa, N; Varagic, J; VonCannon, JL	1
Astarcı, HM; Azak, A; Can, M; Ceri, M; Duranay, M; Huddam, B; Karaca, G; Koçak, G; Sert, M	1
Altieri, PI; Cangiano, JL; Crespo, MJ; Escobales, N	1
Kumagai, H; Matsubara, H; Oda, T; Ohshima, N; Senda, M; Tadano, H; Takechi, H; Uchida, T; Watanabe, A; Yamamoto, K	1
Ferrario, CM; Habibi, J; Hayden, MR; Locher, B; Nistala, R; Pulakat, L; Sinak, C; Sowers, JR; Whaley-Connell, A	1
Alessi, T; Giles, TD; Purkayastha, D; Zappe, D	1
Fan, YY; Hitomi, H; Kitada, K; Kobori, H; Lei, B; Masaki, T; Mori, H; Nakano, D; Nishiyama, A	1
Baschiera, F; Botha, J; Brunel, P; Lacy, PS; Prescott, MF; Williams, B	1
Baker, KM; Chandel, N; Feldman, DL; Kumar, R; Seqqat, R; Thomas, CM; Yong, QC	1
Kalaitzidis, R; Karasavvidou, D; Pappas, K; Siamopoulos, KC; Spanos, G	1
Abe, M; Baba, S; Maruyama, N; Okada, K; Soma, M; Suzuki, H; Takashima, H; Yoshida, Y	1
Ahmad, S; Brosnihan, KB; Ferrario, CM; Gomez, RA; Groban, L; Kato, J; Kitamura, K; Lopez, ML; Moniwa, N; Nagata, S; Simington, SW; Varagic, J; VonCannon, JL; Wang, H	1
Alessi, T; Bakris, GL; Oparil, S; Purkayastha, D; Sowers, JR; Yadao, AM	1
Ardhanari, S; DeMarco, VG; Ferrario, CM; Habibi, J; Hayden, MR; Krueger, C; Pulakat, L; Rehmer, N; Sowers, JR; Whaley-Connell, A	1
Bode, C; Braunwald, E; Brunel, PC; Hoffman, EB; Morrow, DA; Prescott, MF; Ren, F; Rifai, N; Scirica, BM; Swedberg, K; Udell, JA	1
D'Angelo, A; Derosa, G; Fogari, R; Gualtierotti, R; Mugellini, A; Zoppi, A	1
Baker, KM; Chandel, N; Kumar, R; Seqqat, R; Thomas, CM; Yong, QC	1
Coakley, C; Hough, A; Parra, D; Shah, S	2
Campbell, DJ; Koid, SS; Ziogas, J	1
Chou, YM; Ghasemi, O; Iyer, RP; Jin, YF; Levin, DB; Lindsey, ML; Lopez, EF; Ramirez, TA; Zamilpa, R; Zhang, J	1
Howard, A; Kopp, JB; Levi, M; Li, C; Qiu, L; Solis, N; Wang, W; Wang, X	1
Amiya, E; Hirata, Y; Hosoya, Y; Kawarasaki, S; Nagai, R; Nakao, T; Omori, K; Ozeki, A; Tahara, Y; Takata, M; Watanabe, A; Watanabe, M; Watanabe, S; Yamada, N	1
Liu, X; Xu, X; Zhang, C	1
Gambichler, T; Skrygan, M; Susok, L; Zankl, J	1
Deng, J; Gao, C; Hu, B; Yu, S; Zheng, H	1

Reviews

8 review(s) available for valine and fumarates

Article	Year
Anti-angiotensin therapy: new perspectives. Cardiology clinics, 2007, Volume: 25, Issue:4 Topics: Amides; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Chronic Disease; Fumarates; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Renin; Tetrazoles; Treatment Outcome; Valine; Valsartan	2007
Aliskiren/valsartan combination for the treatment of cardiovascular and renal diseases. Expert review of cardiovascular therapy, 2010, Volume: 8, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Drug Combinations; Fumarates; Humans; Kidney Diseases; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Aliskiren/valsartan (Valturna) for hypertension. The Medical letter on drugs and therapeutics, 2009, Nov-30, Volume: 51, Issue:1326 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Drug Combinations; Drug Interactions; Fumarates; Humans; Hypertension; Randomized Controlled Trials as Topic; Renin; Tetrazoles; Valine; Valsartan	2009
[Recent clinical evidences of RAS inhibitors on chronic kidney diseases]. Nihon Jinzo Gakkai shi, 2010, Volume: 52, Issue:2 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; Evidence-Based Medicine; Fumarates; Kidney Diseases; Losartan; Tetrazoles; Valine; Valsartan	2010
The antihypertensive effectiveness and safety of dual RAAS blockade with aliskiren and valsartan. Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46, Issue:3 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Drug Interactions; Drug Therapy, Combination; Fumarates; Humans; Hypertension; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Aliskiren and valsartan combination therapy for the management of hypertension. Vascular health and risk management, 2010, Sep-07, Volume: 6 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Fumarates; Humans; Hypertension; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Single-pill triple-combination therapy: an alternative to multiple-drug treatment of hypertension. Postgraduate medicine, 2011, Volume: 123, Issue:6 Topics: Amides; Amlodipine; Antihypertensive Agents; Drug Combinations; Drug Design; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Medication Adherence; Olmesartan Medoxomil; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tetrazoles; Valine; Valsartan	2011
[Recent advance in kidney and hypertension research]. Nihon Jinzo Gakkai shi, 2012, Volume: 54, Issue:1 Topics: Albuminuria; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Calcium Channel Agonists; Catheter Ablation; Cerebrovascular Circulation; Chronic Disease; Diabetic Nephropathies; Drug Therapy, Combination; Evidence-Based Medicine; Fumarates; Humans; Hypertension; Imidazoles; Kidney; Kidney Diseases; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan	2012

Trials

15 trial(s) available for valine and fumarates

Article	Year
Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Aldosterone; Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cross-Over Studies; Drug Synergism; Feedback, Physiological; Fumarates; Humans; Male; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2004
Conformational changes in prorenin during renin inhibition in vitro and in vivo. Journal of hypertension, 2006, Volume: 24, Issue:3 Topics: Adolescent; Adult; Amides; Antihypertensive Agents; Cross-Over Studies; Double-Blind Method; Fumarates; Humans; Immunoradiometric Assay; Male; Protein Conformation; Renin; Sodium; Tetrazoles; Valine; Valsartan	2006
Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. American journal of hypertension, 2007, Volume: 20, Issue:1 Topics: Adult; Aged; Amides; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Tetrazoles; Valine; Valsartan	2007
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet (London, England), 2007, Jul-21, Volume: 370, Issue:9583 Topics: Amides; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Endpoint Determination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Renin; Tetrazoles; Valine; Valsartan	2007
Hormonal and hemodynamic effects of aliskiren and valsartan and their combination in sodium-replete normotensive individuals. Clinical journal of the American Society of Nephrology : CJASN, 2007, Volume: 2, Issue:5 Topics: Adult; Amides; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Fumarates; Humans; Male; Renin; Sodium; Tetrazoles; Valine; Valsartan	2007
Aliskiren and valsartan in stage 2 hypertension: subgroup analysis of a randomized, double-blind study. Advances in therapy, 2008, Volume: 25, Issue:12 Topics: Aged; Amides; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Tetrazoles; Valine; Valsartan	2008
Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hypertensive patients not adequately responsive to hydrochlorothiazide alone. Journal of clinical hypertension (Greenwich, Conn.), 2009, Volume: 11, Issue:6 Topics: Adult; Aged; Amides; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2009
Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial. European heart journal, 2010, Volume: 31, Issue:16 Topics: Acute Coronary Syndrome; Aged; Amides; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Death, Sudden, Cardiac; Double-Blind Method; Female; Fumarates; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Peptide Fragments; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension. Current medical research and opinion, 2010, Volume: 26, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Algorithms; Amides; Antihypertensive Agents; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Incidence; Male; Middle Aged; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan; Young Adult	2010
Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1 Topics: Adult; Aged; Amides; Arginine; Blood Pressure; Demography; Endpoint Determination; Exercise; Female; Fumarates; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Renin; Renin-Angiotensin System; Systole; Tetrazoles; Valine; Valsartan	2013
Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:4 Topics: Albuminuria; Amides; Antihypertensive Agents; Demography; Female; Fumarates; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Pulse Wave Analysis; Tetrazoles; Treatment Outcome; Valine; Valsartan	2013
Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis. Clinical and experimental nephrology, 2013, Volume: 17, Issue:3 Topics: Adult; Aged; Albuminuria; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Female; Fumarates; Humans; Hypertension; Hypertension, Renal; Male; Middle Aged; Nephritis; Nephrosclerosis; Tetrazoles; Valine; Valsartan	2013
Randomized study of antihypertensive efficacy and safety of combination aliskiren/valsartan vs valsartan monotherapy in hypertensive participants with type 2 diabetes mellitus. Journal of clinical hypertension (Greenwich, Conn.), 2013, Volume: 15, Issue:2 Topics: Aged; Amides; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Comorbidity; Creatinine; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Severity of Illness Index; Tetrazoles; Treatment Outcome; Valine; Valsartan	2013
Effect of naproxen and acetaminophen on blood pressure lowering by ramipril, valsartan and aliskiren in hypertensive patients. Expert opinion on pharmacotherapy, 2013, Volume: 14, Issue:14 Topics: Acetaminophen; Adult; Aged; Amides; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Naproxen; Ramipril; Tetrazoles; Valine; Valsartan	2013
Effect of add-on aliskiren to type 1 angiotensin receptor blocker therapy on endothelial function and autonomic nervous system in hypertensive patients with ischemic heart disease. Journal of clinical hypertension (Greenwich, Conn.), 2014, Volume: 16, Issue:8 Topics: Aged; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Autonomic Nervous System; Comorbidity; Drug Therapy, Combination; Endothelium, Vascular; Female; Fumarates; Heart Rate; Humans; Hypertension; Male; Middle Aged; Myocardial Ischemia; Renin; Tetrazoles; Treatment Outcome; Valine; Valsartan; Vasodilation	2014

Other Studies

40 other study(ies) available for valine and fumarates

Article	Year
Methodological studies on the uptake of zinc by 3T3 cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 149, Issue:4 Topics: Animals; Cell Line; Culture Media; Dose-Response Relationship, Drug; Ethylenediamines; Fumarates; Glycine; Histidine; Hydrogen-Ion Concentration; Mice; Threonine; Time Factors; Valine; Zinc	1975
Sources of carbon skeleton of alanine released from skeletal muscle. Acta physiologica Scandinavica, 1976, Volume: 97, Issue:3 Topics: Alanine; Animals; Aspartic Acid; Female; Fumarates; Glutamates; Hindlimb; Leucine; Muscles; Palmitic Acids; Perfusion; Propionates; Pyruvates; Rats; Valine	1976
Amino acid biosynthesis in mixed rumen cultures. The Biochemical journal, 1975, Volume: 150, Issue:3 Topics: Alanine; Amino Acids; Animals; Bacteria; Cattle; Citric Acid Cycle; Female; Fumarates; Isoleucine; Ketoglutaric Acids; Leucine; Lysine; Oxaloacetates; Oxidation-Reduction; Phenylalanine; Propionates; Pyruvates; Rumen; Serine; Tyrosine; Valine	1975
Effect of aliphatic amino acids and citric acid cycle compounds on early thiamine production by thiazoleless mutant of Escherichia coli. The Journal of vitaminology, 1968, Sep-10, Volume: 14, Issue:3 Topics: Alanine; Amino Acids; Ammonium Chloride; Aspartic Acid; Carbon Isotopes; Culture Media; Dicarboxylic Acids; Escherichia coli; Formates; Fumarates; Glucose; Glutamates; Lysine; Malates; Mutation; Pyruvates; Serine; Succinates; Thiamine; Thiazoles; Valine	1968
Inhibition of gluconeogenesis by alpha-oxo acids. The Biochemical journal, 1964, Volume: 90, Issue:1 Topics: Alanine; Amino Acids; Animals; Benzoates; Cinnamates; Fumarates; Gluconeogenesis; Glucose; In Vitro Techniques; Isoleucine; Keto Acids; Kidney; Lactates; Methionine; Phenylacetates; Phenylpyruvic Acids; Rats; Salicylates; Valine	1964
[Accumulation of free extracellular amino acids by Pseudomonas liquefaciens]. Doklady Akademii nauk SSSR, 1966, Apr-01, Volume: 167, Issue:4 Topics: Acids; Alanine; Amino Acids; Aminobutyrates; Ammonium Chloride; Chromatography; Fumarates; Lactates; Leucine; Levulinic Acids; Malates; Propionates; Pseudomonas; Succinates; Valerates; Valine	1966
Pathways for amino acid metabolism by Prevotella intermedia and Prevotella nigrescens. Oral microbiology and immunology, 2000, Volume: 15, Issue:2 Topics: Acetates; Amino Acids; Ammonia; Anaerobiosis; Aspartic Acid; Culture Media; Formates; Fumarates; Leucine; Malates; Models, Chemical; Prevotella; Succinic Acid; Valine	2000
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. Journal of hypertension, 2005, Volume: 23, Issue:2 Topics: Administration, Oral; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Callithrix; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Female; Fumarates; Heart Rate; Imidazoles; Injections, Intravenous; Male; Piperazines; Rats; Rats, Inbred SHR; Renin; Telemetry; Tetrazoles; Thiazoles; Valine; Valsartan	2005
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:3 Topics: Albuminuria; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Animals, Genetically Modified; Blood Pressure; Cardiomegaly; Dose-Response Relationship, Drug; Echocardiography; Fumarates; Humans; Hypertension; Kidney; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Valine; Valsartan	2005
Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. International journal of clinical practice, 2006, Volume: 60, Issue:11 Topics: Adolescent; Adult; Amides; Amlodipine; Antihypertensive Agents; Drug Interactions; Drug Therapy, Combination; Female; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Ramipril; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2006
Dual inhibition of the renin system by aliskiren and valsartan. Lancet (London, England), 2007, Jul-21, Volume: 370, Issue:9583 Topics: Amides; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Fumarates; Humans; Randomized Controlled Trials as Topic; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2007
Antihypertensive therapies. Nature reviews. Drug discovery, 2007, Volume: 6, Issue:8 Topics: Amides; Antihypertensive Agents; Blood Pressure; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diuretics; Drug Design; Drug Industry; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Renin; Tetrazoles; Valine; Valsartan	2007
Dual inhibition of the renin system by aliskiren and valsartan. Lancet (London, England), 2007, Sep-29, Volume: 370, Issue:9593 Topics: Amides; Antihypertensive Agents; Drug Therapy, Combination; Fumarates; Humans; Hyperkalemia; Hypertension; Renin; Tetrazoles; Valine; Valsartan	2007
Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis. Current medical research and opinion, 2008, Volume: 24, Issue:4 Topics: Aged; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Fumarates; Humans; Hydrochlorothiazide; Hyperkalemia; Hypertension; Male; Middle Aged; Renin; Renin-Angiotensin System; Risk Factors; Tetrazoles; Time Factors; Valine; Valsartan	2008
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:3 Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Atherosclerosis; Biopterins; Blood Pressure; Drug Therapy, Combination; Endothelium, Vascular; Fumarates; Heart Rate; HSP90 Heat-Shock Proteins; Hyperlipidemias; Inflammation Mediators; Lipids; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rabbits; Renin; Tetrazoles; Tyrosine; Valine; Valsartan; Vasodilation; Vasodilator Agents	2008
Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:3 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomegaly; Cardiovascular Diseases; Cardiovascular System; Drug Synergism; Drug Therapy, Combination; Fumarates; Gene Expression; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Receptor, Angiotensin, Type 1; Renin; RNA, Messenger; Superoxides; Tetrazoles; Tunica Intima; Valine; Valsartan	2009
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice. Journal of hypertension, 2010, Volume: 28, Issue:7 Topics: Albuminuria; Amides; Animals; Collagen Type IV; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Synergism; Fumarates; Kidney Glomerulus; Losartan; Male; Mice; Mice, Inbred C57BL; Tetrazoles; Transforming Growth Factor beta; Valine; Valsartan	2010
A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:5 Topics: Actins; Amides; Anatomy, Cross-Sectional; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Collagen; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Fumarates; Immunohistochemistry; Kidney; Kidney Diseases; Kidney Function Tests; Male; Neutrophil Infiltration; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Snail Family Transcription Factors; Tetrazoles; Transcription Factors; Ureteral Obstruction; Valine; Valsartan	2010
[Correction of aldosterone level as marker of RAAS dysfunction in patients with arterial hypertension degree II-III and chronic kidney diseases]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:4 Topics: Aged; Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Drug Therapy, Combination; Enalapril; Female; Fumarates; Humans; Hypertension; Indapamide; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2011
Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice. Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Drug Synergism; Fumarates; Heart; Lipid Peroxidation; Male; Mice; Myocardial Infarction; Myocardium; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Ventricular Remodeling	2012
Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice. Cardiovascular drugs and therapy, 2011, Volume: 25, Issue:6 Topics: Administration, Oral; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Fumarates; Hemodynamics; Immunoblotting; Male; Mice; Mice, Inbred Strains; Myocardial Infarction; Myocardial Reperfusion Injury; Receptor, Angiotensin, Type 1; Renin; Tetrazoles; Valine; Valsartan	2011
Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Therapeutic advances in cardiovascular disease, 2012, Volume: 6, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Disease Models, Animal; Drug Therapy, Combination; Fumarates; Heart Rate; Male; Motor Activity; Random Allocation; Rats; Rats, Inbred Lew; Rats, Transgenic; Receptors, Angiotensin; Renin; Tetrazoles; Valine; Valsartan	2012
Effects of renin-angiotensin-aldosterone system blockade on chlorhexidine gluconate-induced sclerosing encapsulated peritonitis in rats. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2012, Volume: 16, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Chlorhexidine; Fumarates; Matrix Metalloproteinase 2; Peritoneum; Peritonitis; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2012
Aliskiren improves left ventricular dysfunction and reduces cardiac dilation in Syrian cardiomyopathic hamsters. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomyopathy, Dilated; Cricetinae; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Fumarates; Male; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Ventricular Dysfunction, Left	2012
Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Regulatory peptides, 2012, Jun-10, Volume: 176, Issue:1-3 Topics: Acute Kidney Injury; Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Fumarates; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin; Tetrazoles; Valine; Valsartan	2012
Comparative efficacy of aliskiren/valsartan vs valsartan in nocturnal dipper and nondipper hypertensive patients: a pooled analysis. Journal of clinical hypertension (Greenwich, Conn.), 2012, Volume: 14, Issue:5 Topics: Adult; Aged; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Tetrazoles; Treatment Outcome; Valine; Valsartan	2012
Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan. Journal of pharmacological sciences, 2012, Volume: 119, Issue:2 Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fumarates; Kidney; Male; Mice; Mice, Inbred C57BL; Renin; RNA, Messenger; Tetrazoles; Valine; Valsartan	2012
Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clinical science (London, England : 1979), 2013, Volume: 124, Issue:8 Topics: Amides; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Diabetes Mellitus, Experimental; Fumarates; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress; Prorenin Receptor; Receptors, Cell Surface; Renin; Tetrazoles; Valine; Valsartan	2013
Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:2 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Fumarates; Heart Rate; Hemodynamics; Hypertension; Kidney; Male; Rats; Renin; Renin-Angiotensin System; Telemetry; Tetrazoles; Valine; Valsartan	2013
Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling. Metabolism: clinical and experimental, 2013, Volume: 62, Issue:6 Topics: Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cell Size; Drug Interactions; Fibrosis; Fumarates; Mice; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin; Signal Transduction; Tetrazoles; Valine; Valsartan; Ventricular Remodeling	2013
Inhibition of the renin-angiotensin system reduces the rise in serum aldosterone in acute coronary syndrome patients with preserved left ventricular function: observations from the AVANT GARDE-TIMI 43 trial. Clinical chemistry, 2013, Volume: 59, Issue:6 Topics: Acute Coronary Syndrome; Aldosterone; Amides; Angiotensin-Converting Enzyme Inhibitors; Down-Regulation; Female; Fumarates; Humans; Male; Middle Aged; Renin-Angiotensin System; Retrospective Studies; Tetrazoles; Valine; Valsartan; Ventricular Function, Left	2013
Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovascular diabetology, 2013, Nov-12, Volume: 12 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fumarates; Kallikreins; Kininogens; Kinins; Mice; Mice, Knockout; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Tetrazoles; Ultrasonography; Valine; Valsartan	2013
Plasma renin activity testing to guide triple antirenin system drug therapy in a patient with difficult-to-treat hypertension. The Annals of pharmacotherapy, 2014, Volume: 48, Issue:2 Topics: Aged; Amides; Antihypertensive Agents; Carbazoles; Carvedilol; Fumarates; Humans; Hypertension; Male; Propanolamines; Renin; Tetrazoles; Valine; Valsartan	2014
Plasma renin activity testing to guide triple antirenin system drug therapy in a patient with difficult-to-treat hypertension. The Annals of pharmacotherapy, 2013, Volume: 47, Issue:11 Topics: Aged; Amides; Antihypertensive Agents; Blood Pressure; Carbazoles; Carvedilol; Drug Therapy, Combination; Fumarates; Humans; Hypertension; Male; Practice Guidelines as Topic; Precision Medicine; Predictive Value of Tests; Propanolamines; Renin; Renin-Angiotensin System; Tetrazoles; Treatment Outcome; Valine; Valsartan	2013
Aliskiren reduces myocardial ischemia-reperfusion injury by a bradykinin B2 receptor- and angiotensin AT2 receptor-mediated mechanism. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:4 Topics: Amides; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bradykinin; Bradykinin B2 Receptor Antagonists; Cardiotonic Agents; Drug Therapy, Combination; Female; Fumarates; Imidazoles; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B2; Tetrazoles; Valine; Valsartan	2014
Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects. Journal of molecular and cellular cardiology, 2014, Volume: 72 Topics: Amides; Animals; Antihypertensive Agents; Drug Therapy, Combination; Extracellular Matrix; Female; Fumarates; Gene Expression; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; Stroke Volume; Survival Analysis; Systole; Tetrazoles; Valine; Valsartan; Ventricular Function, Left; Ventricular Remodeling	2014
Protective effects of aliskiren and valsartan in mice with diabetic nephropathy. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2014, Volume: 15, Issue:4 Topics: Albumins; Amides; Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Fumarates; Inflammation; Lipid Metabolism; Male; Membrane Proteins; Mesangial Cells; Mice, Inbred DBA; Podocytes; Protective Agents; Proteinuria; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2014
Interface morphology and DFT computation of L-valinium fumarate. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015, Feb-05, Volume: 136 Pt B Topics: Electricity; Electrons; Fumarates; Microscopy, Atomic Force; Models, Molecular; Molecular Conformation; Quantum Theory; Valine	2015
Val/Val glutathione-S-transferase P1 polymorphism predicts nonresponders in psoriasis patients treated with fumaric acid esters. Pharmacogenetics and genomics, 2016, Volume: 26, Issue:5 Topics: Adult; Aged; Female; Fumarates; Glutathione S-Transferase pi; Humans; Male; Middle Aged; Pharmacogenomic Variants; Psoriasis; Severity of Illness Index; Treatment Outcome; Valine	2016
Synthesis of Chiral Oligomer-Grafted Biodegradable Polyurethanes and Their Chiral-Dependent Influence on Bone Marrow Stem Cell Behaviors. Macromolecular rapid communications, 2016, Volume: 37, Issue:16 Topics: Acrylates; Animals; Biocompatible Materials; Biodegradable Plastics; Bone Marrow Cells; Cell Adhesion; Cell Movement; Cell Proliferation; Fumarates; Hematopoietic Stem Cells; Polypropylenes; Polyurethanes; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Stereoisomerism; Valine	2016