valine and aliskiren

valine has been researched along with aliskiren in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (33.96)	29.6817
2010's	35 (66.04)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Azizi, M; Bissery, A; Bura-Rivière, A; Camisasca, RP; Guyenne, TT; Ménard, J; Vaidyanathan, S	1
Cumin, F; Menard, J; Schnell, CR; Webb, RL; Wood, JM	1
Dechend, R; Feldman, DL; Fiebeler, A; Garrelds, IM; Gratze, P; Jan Danser, AH; Luft, FC; Meiners, S; Müller, DN; Pilz, B; Shagdarsuren, E; Webb, RL; Wellner, M	1
Azizi, M; Guyene, TT; Ménard, J; Peyrard, S	1
Bizot, MN; Denouel, J; Dieterich, HA; Dole, WP; Kemp, C; Vaidyanathan, S; Valencia, J; Yeh, CM; Zhao, C	1
Aldigier, JC; Azizi, M; Chiang, Y; Januszewicz, A; Pool, JL; Satlin, A; Schmieder, RE; Zidek, W	1
Birkenhäger, WH; Staessen, JA	1
Fang, H; Oparil, S; Patel, S; Satlin, A; Yarows, SA; Zhang, J	1
Azizi, M; Bissery, A; Bura-Rivière, A; Guyene, TT; Ménard, J	1
Ashiya, M; Smith, RE	1
Oparil, S; Patel, S; Satlin, A; Yarows, SA; Zhang, J	1
Deswal, A; Mann, DL; Ramasubbu, K	1
Chrysant, SG; Dattani, D; Hoppe, UC; Hsu, H; Murray, AV; Patel, S; Zhang, J	1
Akasaka, T; Goto, M; Ikejima, H; Imanishi, T; Kitabata, H; Kuroi, A; Mochizuki, S; Muragaki, Y; Takarada, S; Tanimoto, T; Tsujioka, H; Yoshida, K	1
Fang, H; Oparil, S; Patel, S; Yarows, SA; Zhang, J	1
Barranco, E; Geiger, H; Gorostidi, M; Taylor, A; Xiang, Z; Zhang, J; Zhang, X	1
Dong, YF; Fukuda, M; Kaneko, T; Kataoka, K; Kim-Mitsuyama, S; Matsuba, S; Nakagata, N; Nakamura, T; Nako, H; Ogawa, H; Tokutomi, Y; Yamamoto, E	1
Yarows, SA	1
Dong, YF; Fukuda, M; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Liu, L; Nakamura, T; Nako, H; Ogawa, H; Tokutomi, Y; Yamamoto, E	1
Suzuki, H; Takenaka, T	1
Chrysant, SG	2
Bode, C; Braunwald, E; Cannon, CP; Lopez-Sendon, J; Lukashevich, V; Maboudian, M; McCabe, CH; Morrow, DA; Ogorek, M; Oude Ophuis, AJ; Rifai, N; Ruda, M; Ruzyllo, W; Scirica, BM; Swedberg, K	1
Chang, CH; Chiu, YT; Ku, CL; Shu, KH; Wen, MC; Wu, MJ; Wu, WP	1
Epstein, BJ	1
Chrysant, SG; Dattani, D; Hoppe, UC; Murray, AV; Patel, S; Ritter, S; Zhang, J	1
Derbentseva, EA; Dralova, OV; Ermolaeva, AS; Maksimov, ML; Starodubtsev, AK	1
Higashikuni, Y; Hirata, Y; Iwata, H; Nagai, R; Sata, M; Takaoka, M; Tanaka, K	1
Birnbaum, Y; Castillo, AC; Perez-Polo, JR; Qian, J; Ye, Y	1
Ahmad, S; Ferrario, CM; Moniwa, N; Varagic, J; VonCannon, JL	1
Astarcı, HM; Azak, A; Can, M; Ceri, M; Duranay, M; Huddam, B; Karaca, G; Koçak, G; Sert, M	1
Altieri, PI; Cangiano, JL; Crespo, MJ; Escobales, N	1
Kumagai, H; Matsubara, H; Oda, T; Ohshima, N; Senda, M; Tadano, H; Takechi, H; Uchida, T; Watanabe, A; Yamamoto, K	1
Ferrario, CM; Habibi, J; Hayden, MR; Locher, B; Nistala, R; Pulakat, L; Sinak, C; Sowers, JR; Whaley-Connell, A	1
Alessi, T; Giles, TD; Purkayastha, D; Zappe, D	1
Fan, YY; Hitomi, H; Kitada, K; Kobori, H; Lei, B; Masaki, T; Mori, H; Nakano, D; Nishiyama, A	1
Baschiera, F; Botha, J; Brunel, P; Lacy, PS; Prescott, MF; Williams, B	1
Baker, KM; Chandel, N; Feldman, DL; Kumar, R; Seqqat, R; Thomas, CM; Yong, QC	1
Kalaitzidis, R; Karasavvidou, D; Pappas, K; Siamopoulos, KC; Spanos, G	1
Abe, M; Baba, S; Maruyama, N; Okada, K; Soma, M; Suzuki, H; Takashima, H; Yoshida, Y	1
Ahmad, S; Brosnihan, KB; Ferrario, CM; Gomez, RA; Groban, L; Kato, J; Kitamura, K; Lopez, ML; Moniwa, N; Nagata, S; Simington, SW; Varagic, J; VonCannon, JL; Wang, H	1
Alessi, T; Bakris, GL; Oparil, S; Purkayastha, D; Sowers, JR; Yadao, AM	1
Ardhanari, S; DeMarco, VG; Ferrario, CM; Habibi, J; Hayden, MR; Krueger, C; Pulakat, L; Rehmer, N; Sowers, JR; Whaley-Connell, A	1
Bode, C; Braunwald, E; Brunel, PC; Hoffman, EB; Morrow, DA; Prescott, MF; Ren, F; Rifai, N; Scirica, BM; Swedberg, K; Udell, JA	1
D'Angelo, A; Derosa, G; Fogari, R; Gualtierotti, R; Mugellini, A; Zoppi, A	1
Baker, KM; Chandel, N; Kumar, R; Seqqat, R; Thomas, CM; Yong, QC	1
Coakley, C; Hough, A; Parra, D; Shah, S	2
Campbell, DJ; Koid, SS; Ziogas, J	1
Chou, YM; Ghasemi, O; Iyer, RP; Jin, YF; Levin, DB; Lindsey, ML; Lopez, EF; Ramirez, TA; Zamilpa, R; Zhang, J	1
Howard, A; Kopp, JB; Levi, M; Li, C; Qiu, L; Solis, N; Wang, W; Wang, X	1
Amiya, E; Hirata, Y; Hosoya, Y; Kawarasaki, S; Nagai, R; Nakao, T; Omori, K; Ozeki, A; Tahara, Y; Takata, M; Watanabe, A; Watanabe, M; Watanabe, S; Yamada, N	1

Reviews

8 review(s) available for valine and aliskiren

Article	Year
Anti-angiotensin therapy: new perspectives. Cardiology clinics, 2007, Volume: 25, Issue:4 Topics: Amides; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Chronic Disease; Fumarates; Heart Failure; Humans; Losartan; Randomized Controlled Trials as Topic; Renin; Tetrazoles; Treatment Outcome; Valine; Valsartan	2007
Aliskiren/valsartan combination for the treatment of cardiovascular and renal diseases. Expert review of cardiovascular therapy, 2010, Volume: 8, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Drug Combinations; Fumarates; Humans; Kidney Diseases; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Aliskiren/valsartan (Valturna) for hypertension. The Medical letter on drugs and therapeutics, 2009, Nov-30, Volume: 51, Issue:1326 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Drug Combinations; Drug Interactions; Fumarates; Humans; Hypertension; Randomized Controlled Trials as Topic; Renin; Tetrazoles; Valine; Valsartan	2009
[Recent clinical evidences of RAS inhibitors on chronic kidney diseases]. Nihon Jinzo Gakkai shi, 2010, Volume: 52, Issue:2 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; Evidence-Based Medicine; Fumarates; Kidney Diseases; Losartan; Tetrazoles; Valine; Valsartan	2010
The antihypertensive effectiveness and safety of dual RAAS blockade with aliskiren and valsartan. Drugs of today (Barcelona, Spain : 1998), 2010, Volume: 46, Issue:3 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Drug Interactions; Drug Therapy, Combination; Fumarates; Humans; Hypertension; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Aliskiren and valsartan combination therapy for the management of hypertension. Vascular health and risk management, 2010, Sep-07, Volume: 6 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Fumarates; Humans; Hypertension; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Single-pill triple-combination therapy: an alternative to multiple-drug treatment of hypertension. Postgraduate medicine, 2011, Volume: 123, Issue:6 Topics: Amides; Amlodipine; Antihypertensive Agents; Drug Combinations; Drug Design; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Imidazoles; Medication Adherence; Olmesartan Medoxomil; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tetrazoles; Valine; Valsartan	2011
[Recent advance in kidney and hypertension research]. Nihon Jinzo Gakkai shi, 2012, Volume: 54, Issue:1 Topics: Albuminuria; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Calcium Channel Agonists; Catheter Ablation; Cerebrovascular Circulation; Chronic Disease; Diabetic Nephropathies; Drug Therapy, Combination; Evidence-Based Medicine; Fumarates; Humans; Hypertension; Imidazoles; Kidney; Kidney Diseases; Randomized Controlled Trials as Topic; Tetrazoles; Valine; Valsartan	2012

Trials

15 trial(s) available for valine and aliskiren

Article	Year
Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Aldosterone; Amides; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cross-Over Studies; Drug Synergism; Feedback, Physiological; Fumarates; Humans; Male; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2004
Conformational changes in prorenin during renin inhibition in vitro and in vivo. Journal of hypertension, 2006, Volume: 24, Issue:3 Topics: Adolescent; Adult; Amides; Antihypertensive Agents; Cross-Over Studies; Double-Blind Method; Fumarates; Humans; Immunoradiometric Assay; Male; Protein Conformation; Renin; Sodium; Tetrazoles; Valine; Valsartan	2006
Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. American journal of hypertension, 2007, Volume: 20, Issue:1 Topics: Adult; Aged; Amides; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Tetrazoles; Valine; Valsartan	2007
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet (London, England), 2007, Jul-21, Volume: 370, Issue:9583 Topics: Amides; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Endpoint Determination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Renin; Tetrazoles; Valine; Valsartan	2007
Hormonal and hemodynamic effects of aliskiren and valsartan and their combination in sodium-replete normotensive individuals. Clinical journal of the American Society of Nephrology : CJASN, 2007, Volume: 2, Issue:5 Topics: Adult; Amides; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Fumarates; Humans; Male; Renin; Sodium; Tetrazoles; Valine; Valsartan	2007
Aliskiren and valsartan in stage 2 hypertension: subgroup analysis of a randomized, double-blind study. Advances in therapy, 2008, Volume: 25, Issue:12 Topics: Aged; Amides; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Tetrazoles; Valine; Valsartan	2008
Combination therapy with various combinations of aliskiren, valsartan, and hydrochlorothiazide in hypertensive patients not adequately responsive to hydrochlorothiazide alone. Journal of clinical hypertension (Greenwich, Conn.), 2009, Volume: 11, Issue:6 Topics: Adult; Aged; Amides; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2009
Patients with acute coronary syndromes and elevated levels of natriuretic peptides: the results of the AVANT GARDE-TIMI 43 Trial. European heart journal, 2010, Volume: 31, Issue:16 Topics: Acute Coronary Syndrome; Aged; Amides; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Death, Sudden, Cardiac; Double-Blind Method; Female; Fumarates; Hospitalization; Humans; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Peptide Fragments; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2010
Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension. Current medical research and opinion, 2010, Volume: 26, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Algorithms; Amides; Antihypertensive Agents; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Incidence; Male; Middle Aged; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan; Young Adult	2010
Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1 Topics: Adult; Aged; Amides; Arginine; Blood Pressure; Demography; Endpoint Determination; Exercise; Female; Fumarates; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Renin; Renin-Angiotensin System; Systole; Tetrazoles; Valine; Valsartan	2013
Efficacy of aliskiren and valsartan in hypertensive patients with albuminuria: a randomized parallel-group study. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:4 Topics: Albuminuria; Amides; Antihypertensive Agents; Demography; Female; Fumarates; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Pulse Wave Analysis; Tetrazoles; Treatment Outcome; Valine; Valsartan	2013
Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis. Clinical and experimental nephrology, 2013, Volume: 17, Issue:3 Topics: Adult; Aged; Albuminuria; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Female; Fumarates; Humans; Hypertension; Hypertension, Renal; Male; Middle Aged; Nephritis; Nephrosclerosis; Tetrazoles; Valine; Valsartan	2013
Randomized study of antihypertensive efficacy and safety of combination aliskiren/valsartan vs valsartan monotherapy in hypertensive participants with type 2 diabetes mellitus. Journal of clinical hypertension (Greenwich, Conn.), 2013, Volume: 15, Issue:2 Topics: Aged; Amides; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Comorbidity; Creatinine; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Severity of Illness Index; Tetrazoles; Treatment Outcome; Valine; Valsartan	2013
Effect of naproxen and acetaminophen on blood pressure lowering by ramipril, valsartan and aliskiren in hypertensive patients. Expert opinion on pharmacotherapy, 2013, Volume: 14, Issue:14 Topics: Acetaminophen; Adult; Aged; Amides; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Naproxen; Ramipril; Tetrazoles; Valine; Valsartan	2013
Effect of add-on aliskiren to type 1 angiotensin receptor blocker therapy on endothelial function and autonomic nervous system in hypertensive patients with ischemic heart disease. Journal of clinical hypertension (Greenwich, Conn.), 2014, Volume: 16, Issue:8 Topics: Aged; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Autonomic Nervous System; Comorbidity; Drug Therapy, Combination; Endothelium, Vascular; Female; Fumarates; Heart Rate; Humans; Hypertension; Male; Middle Aged; Myocardial Ischemia; Renin; Tetrazoles; Treatment Outcome; Valine; Valsartan; Vasodilation	2014

Other Studies

30 other study(ies) available for valine and aliskiren

Article	Year
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. Journal of hypertension, 2005, Volume: 23, Issue:2 Topics: Administration, Oral; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Callithrix; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Female; Fumarates; Heart Rate; Imidazoles; Injections, Intravenous; Male; Piperazines; Rats; Rats, Inbred SHR; Renin; Telemetry; Tetrazoles; Thiazoles; Valine; Valsartan	2005
Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:3 Topics: Albuminuria; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Animals, Genetically Modified; Blood Pressure; Cardiomegaly; Dose-Response Relationship, Drug; Echocardiography; Fumarates; Humans; Hypertension; Kidney; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Valine; Valsartan	2005
Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. International journal of clinical practice, 2006, Volume: 60, Issue:11 Topics: Adolescent; Adult; Amides; Amlodipine; Antihypertensive Agents; Drug Interactions; Drug Therapy, Combination; Female; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Ramipril; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2006
Dual inhibition of the renin system by aliskiren and valsartan. Lancet (London, England), 2007, Jul-21, Volume: 370, Issue:9583 Topics: Amides; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Fumarates; Humans; Randomized Controlled Trials as Topic; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2007
Antihypertensive therapies. Nature reviews. Drug discovery, 2007, Volume: 6, Issue:8 Topics: Amides; Antihypertensive Agents; Blood Pressure; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Diuretics; Drug Design; Drug Industry; Fumarates; Humans; Hydrochlorothiazide; Hypertension; Renin; Tetrazoles; Valine; Valsartan	2007
Dual inhibition of the renin system by aliskiren and valsartan. Lancet (London, England), 2007, Sep-29, Volume: 370, Issue:9593 Topics: Amides; Antihypertensive Agents; Drug Therapy, Combination; Fumarates; Humans; Hyperkalemia; Hypertension; Renin; Tetrazoles; Valine; Valsartan	2007
Long-term safety, tolerability and efficacy of aliskiren in combination with valsartan in patients with hypertension: a 6-month interim analysis. Current medical research and opinion, 2008, Volume: 24, Issue:4 Topics: Aged; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Female; Fumarates; Humans; Hydrochlorothiazide; Hyperkalemia; Hypertension; Male; Middle Aged; Renin; Renin-Angiotensin System; Risk Factors; Tetrazoles; Time Factors; Valine; Valsartan	2008
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 52, Issue:3 Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Atherosclerosis; Biopterins; Blood Pressure; Drug Therapy, Combination; Endothelium, Vascular; Fumarates; Heart Rate; HSP90 Heat-Shock Proteins; Hyperlipidemias; Inflammation Mediators; Lipids; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rabbits; Renin; Tetrazoles; Tyrosine; Valine; Valsartan; Vasodilation; Vasodilator Agents	2008
Aliskiren enhances the protective effects of valsartan against cardiovascular and renal injury in endothelial nitric oxide synthase-deficient mice. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:3 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomegaly; Cardiovascular Diseases; Cardiovascular System; Drug Synergism; Drug Therapy, Combination; Fumarates; Gene Expression; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases; Nitric Oxide Synthase Type III; Receptor, Angiotensin, Type 1; Renin; RNA, Messenger; Superoxides; Tetrazoles; Tunica Intima; Valine; Valsartan	2009
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice. Journal of hypertension, 2010, Volume: 28, Issue:7 Topics: Albuminuria; Amides; Animals; Collagen Type IV; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Drug Synergism; Fumarates; Kidney Glomerulus; Losartan; Male; Mice; Mice, Inbred C57BL; Tetrazoles; Transforming Growth Factor beta; Valine; Valsartan	2010
A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:5 Topics: Actins; Amides; Anatomy, Cross-Sectional; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Collagen; Drug Therapy, Combination; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Fumarates; Immunohistochemistry; Kidney; Kidney Diseases; Kidney Function Tests; Male; Neutrophil Infiltration; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Snail Family Transcription Factors; Tetrazoles; Transcription Factors; Ureteral Obstruction; Valine; Valsartan	2010
[Correction of aldosterone level as marker of RAAS dysfunction in patients with arterial hypertension degree II-III and chronic kidney diseases]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:4 Topics: Aged; Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biomarkers; Drug Therapy, Combination; Enalapril; Female; Fumarates; Humans; Hypertension; Indapamide; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2011
Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice. Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Drug Synergism; Fumarates; Heart; Lipid Peroxidation; Male; Mice; Myocardial Infarction; Myocardium; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Ventricular Remodeling	2012
Aliskiren and Valsartan reduce myocardial AT1 receptor expression and limit myocardial infarct size in diabetic mice. Cardiovascular drugs and therapy, 2011, Volume: 25, Issue:6 Topics: Administration, Oral; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Fumarates; Hemodynamics; Immunoblotting; Male; Mice; Mice, Inbred Strains; Myocardial Infarction; Myocardial Reperfusion Injury; Receptor, Angiotensin, Type 1; Renin; Tetrazoles; Valine; Valsartan	2011
Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats. Therapeutic advances in cardiovascular disease, 2012, Volume: 6, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Disease Models, Animal; Drug Therapy, Combination; Fumarates; Heart Rate; Male; Motor Activity; Random Allocation; Rats; Rats, Inbred Lew; Rats, Transgenic; Receptors, Angiotensin; Renin; Tetrazoles; Valine; Valsartan	2012
Effects of renin-angiotensin-aldosterone system blockade on chlorhexidine gluconate-induced sclerosing encapsulated peritonitis in rats. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 2012, Volume: 16, Issue:1 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Chlorhexidine; Fumarates; Matrix Metalloproteinase 2; Peritoneum; Peritonitis; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2012
Aliskiren improves left ventricular dysfunction and reduces cardiac dilation in Syrian cardiomyopathic hamsters. Journal of cardiovascular pharmacology, 2012, Volume: 59, Issue:6 Topics: Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomyopathy, Dilated; Cricetinae; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Fumarates; Male; Renin; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Ventricular Dysfunction, Left	2012
Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Regulatory peptides, 2012, Jun-10, Volume: 176, Issue:1-3 Topics: Acute Kidney Injury; Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Fumarates; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin; Tetrazoles; Valine; Valsartan	2012
Comparative efficacy of aliskiren/valsartan vs valsartan in nocturnal dipper and nondipper hypertensive patients: a pooled analysis. Journal of clinical hypertension (Greenwich, Conn.), 2012, Volume: 14, Issue:5 Topics: Adult; Aged; Amides; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fumarates; Humans; Hypertension; Male; Middle Aged; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Tetrazoles; Treatment Outcome; Valine; Valsartan	2012
Add-on aliskiren elicits stronger renoprotection than high-dose valsartan in type 2 diabetic KKAy mice that do not respond to low-dose valsartan. Journal of pharmacological sciences, 2012, Volume: 119, Issue:2 Topics: Albuminuria; Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fumarates; Kidney; Male; Mice; Mice, Inbred C57BL; Renin; RNA, Messenger; Tetrazoles; Valine; Valsartan	2012
Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clinical science (London, England : 1979), 2013, Volume: 124, Issue:8 Topics: Amides; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Diabetes Mellitus, Experimental; Fumarates; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress; Prorenin Receptor; Receptors, Cell Surface; Renin; Tetrazoles; Valine; Valsartan	2013
Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension. Hypertension (Dallas, Tex. : 1979), 2013, Volume: 61, Issue:2 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Fumarates; Heart Rate; Hemodynamics; Hypertension; Kidney; Male; Rats; Renin; Renin-Angiotensin System; Telemetry; Tetrazoles; Valine; Valsartan	2013
Renin inhibition and AT(1)R blockade improve metabolic signaling, oxidant stress and myocardial tissue remodeling. Metabolism: clinical and experimental, 2013, Volume: 62, Issue:6 Topics: Aldosterone; Amides; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cell Size; Drug Interactions; Fibrosis; Fumarates; Mice; Myocardium; Myocytes, Cardiac; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Receptor, Angiotensin, Type 1; Renin; Signal Transduction; Tetrazoles; Valine; Valsartan; Ventricular Remodeling	2013
Inhibition of the renin-angiotensin system reduces the rise in serum aldosterone in acute coronary syndrome patients with preserved left ventricular function: observations from the AVANT GARDE-TIMI 43 trial. Clinical chemistry, 2013, Volume: 59, Issue:6 Topics: Acute Coronary Syndrome; Aldosterone; Amides; Angiotensin-Converting Enzyme Inhibitors; Down-Regulation; Female; Fumarates; Humans; Male; Middle Aged; Renin-Angiotensin System; Retrospective Studies; Tetrazoles; Valine; Valsartan; Ventricular Function, Left	2013
Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovascular diabetology, 2013, Nov-12, Volume: 12 Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fumarates; Kallikreins; Kininogens; Kinins; Mice; Mice, Knockout; Myocytes, Cardiac; Receptor, Angiotensin, Type 1; Renin; Renin-Angiotensin System; Tetrazoles; Ultrasonography; Valine; Valsartan	2013
Plasma renin activity testing to guide triple antirenin system drug therapy in a patient with difficult-to-treat hypertension. The Annals of pharmacotherapy, 2014, Volume: 48, Issue:2 Topics: Aged; Amides; Antihypertensive Agents; Carbazoles; Carvedilol; Fumarates; Humans; Hypertension; Male; Propanolamines; Renin; Tetrazoles; Valine; Valsartan	2014
Plasma renin activity testing to guide triple antirenin system drug therapy in a patient with difficult-to-treat hypertension. The Annals of pharmacotherapy, 2013, Volume: 47, Issue:11 Topics: Aged; Amides; Antihypertensive Agents; Blood Pressure; Carbazoles; Carvedilol; Drug Therapy, Combination; Fumarates; Humans; Hypertension; Male; Practice Guidelines as Topic; Precision Medicine; Predictive Value of Tests; Propanolamines; Renin; Renin-Angiotensin System; Tetrazoles; Treatment Outcome; Valine; Valsartan	2013
Aliskiren reduces myocardial ischemia-reperfusion injury by a bradykinin B2 receptor- and angiotensin AT2 receptor-mediated mechanism. Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:4 Topics: Amides; Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Bradykinin; Bradykinin B2 Receptor Antagonists; Cardiotonic Agents; Drug Therapy, Combination; Female; Fumarates; Imidazoles; Models, Animal; Myocardial Infarction; Myocardial Reperfusion Injury; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B2; Tetrazoles; Valine; Valsartan	2014
Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects. Journal of molecular and cellular cardiology, 2014, Volume: 72 Topics: Amides; Animals; Antihypertensive Agents; Drug Therapy, Combination; Extracellular Matrix; Female; Fumarates; Gene Expression; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardium; Stroke Volume; Survival Analysis; Systole; Tetrazoles; Valine; Valsartan; Ventricular Function, Left; Ventricular Remodeling	2014
Protective effects of aliskiren and valsartan in mice with diabetic nephropathy. Journal of the renin-angiotensin-aldosterone system : JRAAS, 2014, Volume: 15, Issue:4 Topics: Albumins; Amides; Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Fumarates; Inflammation; Lipid Metabolism; Male; Membrane Proteins; Mesangial Cells; Mice, Inbred DBA; Podocytes; Protective Agents; Proteinuria; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan	2014