valine has been researched along with a 74704 in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bryant, P; Codacovi, L; Kempf, DJ; Knigge, MF; Kohlbrenner, WE; Marsh, KC; Norbeck, DW; Paul, DA; Vasavanonda, S; Wang, XC | 1 |
| Erickson, J; Kempf, DJ; Neidhart, DJ; Norbeck, DW; Plattner, JJ; Rittenhouse, JW; Turon, M; VanDrie, J; Wang, XC; Wideburg, N | 1 |
| Kuntz, ID; Roe, DC | 1 |
| Erickson, J; Kempf, D | 1 |
| Abraham, DJ; Kellogg, GE | 1 |
| Fujisawa, Y; Kakinuma, A | 1 |
| Cohen, NC; Tschinke, V | 1 |
| Abdel-Meguid, SS; Choi, JK; Culp, JS; Debouck, C; DesJarlais, RL; Minnich, MD; Murthy, KH; Tomaszek, TA; Winborne, E; Zhao, B | 1 |
| Murcko, MA; Rao, BG | 1 |
| Maggiora, GM; Mestres, J; Rohrer, DC | 1 |
| Hwang, MJ; Lee, CY; Tzou, WS; Yang, PK | 1 |
| Domagala, J; Ellsworth, EL; Ferguson, D; Graham, N; Hagen, S; Holler, T; Hupe, D; Lunney, EA; Nouhan, C; Prasad, JV; Tummino, PJ; Zeikus, G | 1 |
2 review(s) available for valine and a 74704
| Article | Year |
|---|---|
Structure-based design of symmetric inhibitors of HIV-1 protease.
Topics: Drug Design; HIV Protease; HIV Protease Inhibitors; HIV-1; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Sugar Alcohols; Valine | 1994 |
[HIV protease inhibitors].
Topics: Acremonium; Amino Acid Sequence; Base Sequence; Cell Cycle Proteins; Cerulenin; Gene Expression Regulation, Enzymologic; Genetic Code; HIV Protease; HIV Protease Inhibitors; Molecular Sequence Data; Oligopeptides; Pepstatins; Peptide Elongation Factor 1; Protein Conformation; Proteins; Sugar Alcohols; Valine | 1993 |
10 other study(ies) available for valine and a 74704
| Article | Year |
|---|---|
Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; Biological Availability; Cytopathogenic Effect, Viral; Dogs; Female; Half-Life; HIV Antigens; HIV Protease; HIV-1; Macaca fascicularis; Male; Molecular Sequence Data; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Sugar Alcohols; Valine | 1991 |
Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease.
Topics: Amino Acid Sequence; Binding Sites; Drug Design; Endopeptidases; Gene Products, pol; HIV Protease; HIV-1; Kinetics; Models, Molecular; Molecular Sequence Data; Protease Inhibitors; Protein Conformation; Sugar Alcohols; Valine | 1990 |
BUILDER v.2: improving the chemistry of a de novo design strategy.
Topics: Algorithms; Binding Sites; Databases, Factual; Drug Design; Evaluation Studies as Topic; HIV Protease Inhibitors; Methotrexate; Models, Chemical; Molecular Structure; Software; Sugar Alcohols; Valine | 1995 |
The effect of physical organic properties on hydrophobic fields.
Topics: Chemical Phenomena; Chemistry, Physical; Computer Simulation; HIV Protease; HIV Protease Inhibitors; Hydrogen Bonding; Models, Molecular; Molecular Structure; Protein Binding; Software; Sugar Alcohols; Valine; Water | 1994 |
The NEWLEAD program: a new method for the design of candidate structures from pharmacophoric hypotheses.
Topics: Algorithms; Computer Simulation; Drug Design; HIV Protease Inhibitors; Indomethacin; Methotrexate; Models, Molecular; Molecular Structure; Software; Sugar Alcohols; Valine | 1993 |
Inhibition of human immunodeficiency virus-1 protease by a C2-symmetric phosphinate. Synthesis and crystallographic analysis.
Topics: Amino Acid Sequence; Binding Sites; Catalysis; Crystallization; HIV Protease; HIV Protease Inhibitors; HIV-1; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Organophosphorus Compounds; Phosphinic Acids; Protein Binding; Recombinant Proteins; Sugar Alcohols; Valine; X-Ray Diffraction | 1993 |
Free energy perturbation studies on binding of A-74704 and its diester analog to HIV-1 protease.
Topics: Binding Sites; Drug Design; HIV Protease; HIV Protease Inhibitors; Hydrogen Bonding; In Vitro Techniques; Molecular Structure; Protein Engineering; Sugar Alcohols; Thermodynamics; Valine | 1996 |
A molecular field-based similarity approach to pharmacophoric pattern recognition.
Topics: Carbamates; Computer Graphics; Furans; HIV Protease; HIV Protease Inhibitors; Models, Molecular; Molecular Structure; Oligopeptides; Pattern Recognition, Automated; Sugar Alcohols; Sulfonamides; Valine | 1997 |
Estimates of relative binding free energies for HIV protease inhibitors using different levels of approximations.
Topics: Chemical Phenomena; Chemistry, Physical; HIV Protease; HIV Protease Inhibitors; Methylurea Compounds; Oligopeptides; Pyridines; Sugar Alcohols; Thermodynamics; Valine | 1998 |
4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.
Topics: Binding Sites; Computer Simulation; Drug Design; HIV Protease; HIV Protease Inhibitors; Hydrocarbons, Aromatic; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Pyrones; Software; Structure-Activity Relationship; Sugar Alcohols; Valine | 1999 |