Page last updated: 2024-09-04

valerylsalicylate and indomethacin

valerylsalicylate has been researched along with indomethacin in 9 studies

Compound Research Comparison

Studies
(valerylsalicylate)
Trials
(valerylsalicylate)
Recent Studies (post-2010)
(valerylsalicylate)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
240529,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyvalerylsalicylate (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's7 (77.78)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erickson, BA; Kaminski, DL; Longo, WE; Mazuski, JE; Panesar, N1
Chen, BC; Hsu, YW; Lee, CM; Lin, WW; Shyue, SK1
Davidson, ME; Lang, RJ1
Eriksson, E; Hellstrand, M; Nilsson, CL1
Calixto, JB; El Sayah, M1
Brum-Fernandes, AJ; Peters, RR; Ribeiro-do-Valle, RM; Siqueira-Junior, JM1
Feletou, M; Gluais, P; Lonchampt, M; Morrow, JD; Vanhoutte, PM1
Akarsu, ES; Algan, E; Ozdayi, S; Ulupinar, F1
Candelario-Jalil, E; Estrada, EY; Fiebich, BL; Grossetete, M; Rosenberg, GA; Sood, R; Taheri, S; Yang, Y1

Other Studies

9 other study(ies) available for valerylsalicylate and indomethacin

ArticleYear
The effect of selective cyclooxygenase inhibitors on intestinal epithelial cell mitogenesis.
    The Journal of surgical research, 1999, Volume: 81, Issue:1

    Topics: Animals; Apoptosis; Blood; Blotting, Western; Cell Division; Cell Line; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; DNA; Epithelial Cells; Indomethacin; Intestines; Isoenzymes; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Salicylates; Tumor Cells, Cultured

1999
Modulation of inducible nitric oxide synthase induction by prostaglandin E2 in macrophages: distinct susceptibility in murine J774 and RAW 264.7 macrophages.
    Prostaglandins & other lipid mediators, 1999, Volume: 58, Issue:2-4

    Topics: Animals; Bucladesine; Cell Line; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Indomethacin; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Salicylates

1999
Effects of selective inhibitors of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) on the spontaneous myogenic contractions in the upper urinary tract of the guinea-pig and rat.
    British journal of pharmacology, 2000, Volume: 129, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Guinea Pigs; Indomethacin; Isoenzymes; Kidney Pelvis; Male; Membrane Proteins; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salicylates; Sulfonamides; Ureter

2000
Dopamine D(2) receptor-induced COX-2-mediated production of prostaglandin E(2) in D(2)-transfected Chinese hamster ovary cells without simultaneous administration of a Ca(2+)-mobilizing agent.
    Biochemical pharmacology, 2002, Jun-15, Volume: 63, Issue:12

    Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclooxygenase 2; Dinoprostone; Dopamine; Dopamine Antagonists; Drug Interactions; Enzyme Inhibitors; Gallic Acid; Indomethacin; Isoenzymes; Naphthalenes; Nitrobenzenes; Phosphatidylcholines; Prostaglandin-Endoperoxide Synthases; Pyrones; Quinacrine; Receptors, Dopamine D2; Salicylamides; Salicylates; Sulfonamides; Tetradecanoylphorbol Acetate; Transfection

2002
Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro.
    European journal of pharmacology, 2003, Jan-01, Volume: 458, Issue:1-2

    Topics: Animals; Atropine; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanethidine; Ibuprofen; Imidazoles; In Vitro Techniques; Indomethacin; Iris; Kallidin; Muscle Contraction; Muscle, Smooth; Nitrobenzenes; Propionates; Quinolines; Salicylates; Sulfonamides; Swine; Tetrodotoxin; Thromboxane-A Synthase

2003
Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice.
    Pharmacological research, 2003, Volume: 48, Issue:5

    Topics: Acute Disease; Animals; Arachidonic Acid; Carrageenan; Celecoxib; Croton Oil; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ear, External; Edema; Foot; Indomethacin; Inflammation; Irritants; Isoenzymes; Male; Membrane Proteins; Mice; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Salicylates; Sulfonamides

2003
Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin.
    British journal of pharmacology, 2005, Volume: 146, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, Thoracic; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Imidazoles; In Vitro Techniques; Indomethacin; Nitrobenzenes; Prostaglandins; Prostaglandins I; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Salicylates; Sulfonamides; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents

2005
The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction.
    Epilepsy research, 2006, Volume: 71, Issue:2-3

    Topics: Animals; Convulsants; Cyclooxygenase Inhibitors; Diclofenac; Escherichia coli; Indomethacin; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Motor Activity; Pentylenetetrazole; Pyrazoles; Salicylates; Seizures; Sulfonamides; Time Factors

2006
Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:2

    Topics: Animals; Blood-Brain Barrier; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Glutathione; Indomethacin; Injections, Intraventricular; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Rats; Rats, Wistar; Recombinant Proteins; Salicylates; Tumor Necrosis Factor-alpha

2007