valerenic-acid has been researched along with isopimaric-acid* in 1 studies
1 other study(ies) available for valerenic-acid and isopimaric-acid
| Article | Year |
|---|---|
Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics.
Natural products (NPs) are progressively recognized as invaluable source of pharmacological tools and lead structures. To enable NP-inspired retinoid X receptor (RXR) modulator design, three novel RXR-targeting NPs were computationally identified. Among them, valerenic acid was found to be selective for RXRβ, rendering it a unique pharmacological tool compound. The NPs then served as templates for automated, ligand-based de novo design of innovative, easily accessible mimetics that inherited the biological activities of their natural templates. Topics: Abietanes; Biological Products; Carboxylic Acids; Computational Biology; Drug Discovery; Drug Evaluation, Preclinical; Hep G2 Cells; Humans; Indenes; Ligands; Phenanthrenes; Retinoid X Receptors; Sesquiterpenes | 2018 |