valerates has been researched along with leucine in 177 studies
| Studies (valerates) | Trials (valerates) | Recent Studies (post-2010) (valerates) | Studies (leucine) | Trials (leucine) | Recent Studies (post-2010) (leucine) |
|---|---|---|---|---|---|
| 2,251 | 294 | 457 | 28,515 | 744 | 4,178 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 120 (67.80) | 18.7374 |
| 1990's | 11 (6.21) | 18.2507 |
| 2000's | 6 (3.39) | 29.6817 |
| 2010's | 34 (19.21) | 24.3611 |
| 2020's | 6 (3.39) | 2.80 |
| Authors | Studies |
|---|---|
| Mahoney, MJ | 1 |
| Blaskovics, ME; Donnell, GN; Ng, WG | 1 |
| Amédée-Manesme, O; Besson-Leaud, M; Charpentier, C; Checouri, A; Coude, FX; Ferre, P; Lavaud, J; Leraillez, J; Mselati, JC; Ogier, H; Saudubray, JM | 1 |
| Landaas, S | 1 |
| Porath, U; Schreier, K | 1 |
| Blum, JJ; Borowitz, M; Liang, T; Raugi, G | 1 |
| Lehnert, W; Niederhoff, H; Schenck, W | 1 |
| Cohn, RM; Puschak, R; Rothman, R; Segal, S; Yudkoff, M | 1 |
| Owen, OE; Patel, MS | 1 |
| Elsden, SR; Hilton, MG | 1 |
| Hidaka, T | 1 |
| Goodman, HM | 2 |
| Di Campo-Rougerie, C; Mahmoud, F; Ramahandridona, G; Vague, P | 1 |
| Doolittle, WF; Singer, RA | 1 |
| Dogen, M; Higashi, T; Kawamata, F | 1 |
| Chawla, RK; Khatra, BS; Rudman, D; Wadsworth, AD | 1 |
| Mandell, R; Shih, VE; Tanaka, K | 2 |
| Charpentier, C; Depondt, E; Herouin, C; Pousset, JL; Saudubray, JM; Sorin, M | 1 |
| Oxender, DL; Quay, SC; Tsuyumu, S; Umbarger, HE | 1 |
| Geier, MR; Kamerow, HN; LaPolla, RJ; Merril, CR; Trigg, ME | 1 |
| Bogair, N; Charles, R; Gil-Av, E; Legum, C; Spirer, Z; Swirsky-Fein, S; Zakut, V | 1 |
| Higashi, T; Kawamata, F; Sakurai, T | 1 |
| Blailock, TT; Blomquist, GJ | 1 |
| Mock, DM; Mock, NI | 1 |
| Chalmers, RA; Halliday, D; Thompson, GN | 1 |
| Nissen, S; Van Koevering, M | 1 |
| Inoue, Y; Iwasaki, R; Kuhara, T; Matsumoto, I; Morimoto, S; Yu, WM | 1 |
| Nissen, S; Van Koevering, M; Webb, D | 1 |
| Beaudet, AL; Craigen, WJ; Gibson, KM; Johnston, K; Kamali, V; Lee, CF; Powell, BR; Schwartz, R; Tsai, MY; Tuchman, M | 1 |
| Tanaka, K | 1 |
| Dembure, P; Elsas, L; Madsen, K; Naglak, M; Salvo, R | 1 |
| Elsas, LJ; Naglak, M | 1 |
| Flakoll, PJ; Kuhlman, G; Nissen, S; Roth, JA; Vandehaar, MJ | 1 |
| Hyman, D; Ikeda, Y; Matsubara, Y; Tanaka, K | 1 |
| Herbertz, L; Langer, K; Schauder, P | 1 |
| Ruchim, MA; Zarling, EJ | 1 |
| Pollitt, RJ | 1 |
| Hyman, DB; Tanaka, K | 1 |
| Inoue, F; Maltby, DA; Millington, DS; Roe, CR | 1 |
| Draffan, GH; Gompertz, D; Hull, D; Watts, JL | 1 |
| Erickson, AM; Kurtz, DJ; Levy, HL; Lott, IT | 1 |
| Conrad, RS; Massey, LK; Sokatch, JR | 1 |
| Christians, J; Hasselblatt, A; Panten, U; Poser, W; von Kriegstein, E | 1 |
| Adair, R; Davidoff, RA | 1 |
| Callaghan, P; Newman, CG; Wilson, BD; Young, L | 1 |
| Fujii, Y; Kodama, H; Mizuhara, S; Tanaka, K | 1 |
| Yamaguchi, T | 1 |
| Misono, H; Mori, K; Sakato, H; Soda, K | 1 |
| Markau, K; Steinhübel, I | 1 |
| Markau, K | 1 |
| Kohlhaw, GB; Ryan, ED; Tracy, JW | 1 |
| Berg, CP; Cruz, LJ; Glesne, LB | 1 |
| Borison, HL; McCarthy, LE; Pendleton, J | 1 |
| Kline, EL | 1 |
| Chibata, I; Kisumi, M; Komatsubara, S | 1 |
| Amzallag, A; Middleton, RB; Somers, JM | 1 |
| Kohlhaw, GB; Teng-Leary, E | 1 |
| Kessler, DP; Yang, HL | 1 |
| Calvo, JM; Friedberg, D; Jones, J; Mikulka, TW | 1 |
| Kemper, J | 1 |
| Gompertz, D | 1 |
| McGilvray, D; Umbarger, HE | 1 |
| Lönnberg, H; Nurmikko, V; Puukka, M | 1 |
| Lönnberg, H; Mäntsälä, P; Nurmikko, V; Pajula, R; Puukka, M | 1 |
| Ridge, B; Rydon, HN; Snell, CR | 1 |
| Daron, HH | 1 |
| Bartlett, K; Blair, D; Gompertz, D; Stern, CM | 1 |
| Angielski, SA; Lysiak, W; Pieńkowska-Vogel, M; Szutowicz, A | 1 |
| Engel, PC | 1 |
| Kaplan, JG; McDonald, RA; Satyanarayana, T | 1 |
| Gross, SR; Olshan, AR | 1 |
| Calvo, JM; Stieglitz, BI | 1 |
| Bensch, KG; Bissell, MG; Herman, MM | 1 |
| Boatman, G; Kohlhaw, G | 1 |
| Bartholomew, JC; Calvo, JM | 2 |
| Kohlhaw, G; Leary, TR; Umbarger, HE | 1 |
| Hildesheim, R; Kunesch, G; Polonsky, J | 1 |
| Hill, F; Schlegel, HG | 1 |
| Demny, TC; Pruess, DL; Scannell, JP; Weiss, F; Williams, T | 1 |
| Pardee, AB; Willecke, K | 1 |
| Isselbacher, KJ; Shih, V; Tanaka, K | 1 |
| Prescott, JM; Wagner, FW; Wilkes, SH | 1 |
| Erickson, AM; Levy, HL; Lott, IT | 1 |
| Mangan, JL | 1 |
| Eldjarn, L; Jellum, E; Pande, H; Stokke, O; Waaler, PE | 1 |
| Malins, DC; Robisch, PA; Varanasi, U | 1 |
| Goedde, HW; Langenbeck, U; Rüdiger, HW | 1 |
| Böhme, R; Kohlhaw, G; Ulm, EH | 1 |
| Achari, RG; Court, WE; Newcombe, F | 1 |
| Kishimoto, Y; Kurtz, DJ; Levy, HL; Plotkin, W | 1 |
| Lahoud, H; McManus, WR; Prichard, PK; Schofield, PJ | 1 |
| Budd, MA; Efron, ML; Isselbacher, KJ; Tanaka, K | 1 |
| Isselbacher, KJ; Miller, EM; Tanaka, K | 1 |
| Burns, RO; Calvo, J; Margolin, P; Umbarger, HE | 1 |
| Bussey, H | 1 |
| Malins, DC; Varanasi, U | 1 |
| Ormerod, JG; Sirevåg, R | 1 |
| Jenkins, WT; Shakespeare, V; Taylor, RT | 1 |
| Angielski, S; Lysiak, W; Stepiński, J | 1 |
| Kaneda, T | 1 |
| McFarlane, IG; Von Holt, C | 1 |
| Drapanas, T; McMenamy, RH; Vang, J | 1 |
| Allison, MJ; Bucklin, JA; Robinson, IM | 1 |
| Orlova, IG; Shaposhnikov, VN | 1 |
| Isselbacher, KJ; Tanaka, K | 1 |
| Blanco, A; Domenech, CE | 1 |
| Cann, HM; Gibson, KM; Greene, CL; Holm, J; Nyhan, WL; Robinson, BH; Sweetman, L | 1 |
| Prieto, EC; Velazquez, A | 1 |
| Beemer, FA; Bruinvis, L; Duran, M; Ketting, D; Tibosch, AS; Wadman, SK | 1 |
| Jakobs, C; Nyhan, WL; Packman, S; Sweetman, L | 1 |
| Goldstein, F; Norton, PM; Sansaricq, C; Snyderman, SE | 1 |
| Hine, DG; Tanaka, K | 1 |
| Hokland, B; Spydevold, O | 1 |
| Duran, M; Houstková, H; Hyánek, J; Kozich, V; Pĕtová, J; Pisacka, M; Rubín, A; Wadman, SK; Zapadlo, M; Zeman, J | 1 |
| Britz, ML; Wilkinson, RG | 1 |
| French, NP; Grauaug, A; Wysocki, SJ | 1 |
| Duran, M; Kamerling, JP; Wadman, SK | 1 |
| Berry, HK; Denton, MD; Norman, EJ | 1 |
| Baker, DH; Boebel, KP | 1 |
| Inoue, Y; Kameyama, J; Momoi, T; Shigematsu, Y; Sudo, M; Suzuki, Y | 1 |
| Bakkeren, JA; Houben, ML; Ruitenbeek, W; Sengers, RC; Trijbels, JM; Van der Zeè, SP | 1 |
| Lehnert, W; Niederhoff, H | 1 |
| August, CS; Cohn, RM; Hutchinson, R; Kelleher, JF; Yudkoff, M | 1 |
| Hoffer, LJ; Mamer, OA; Reimer, ML; Robitaille, L; Taveroff, A | 1 |
| Bain, MS; Burns, SP; Chalmers, RA; Holmes, HC; Iles, RA | 1 |
| Abumrad, N; Connelly, AS; Fuller, JC; Nissen, S; Rathmacher, JA; Ray, M; Rice, D; Sharp, R | 1 |
| Kreider, RB | 1 |
| Dreifort, GD; Vukovich, MD | 1 |
| de Almeida, IT; Duran, M; Maya, M; Overmars, H; Selhorst, J; Silva, MF; van Gennip, AH; Wanders, RJ | 1 |
| Bode, HB; Höfle, G; Kroppenstedt, RM; Mahmud, T; Müller, R; Nordhoff, S; Silakowski, B; Xu, M | 1 |
| Carnell, N; Henrich, CL; Mock, DM; Mock, NI | 1 |
| Engelke, UF; Kluijtmans, LA; Kremer, B; Loss, S; Loupatty, FJ; Morava, E; Moskau, D; van den Bergh, E; van der Graaf, M; Wanders, RJ; Wevers, RA | 1 |
| Espinosa-Artiles, P; Kithsiri Wijeratne, EM; Leslie Gunatilaka, AA; Molnár, I; Orozco, R; Patricia Stock, S; Xu, Y | 1 |
| Amaral, AU; Fernandes, CG; Leipnitz, G; Schuck, PF; Seminotti, B; Wajner, M | 1 |
| de Siqueira Filho, MA; Felitti, V; Gerlinger-Romero, F; Guimarães-Ferreira, L; Lancha, AH; Lira, FS; Seelaender, M; Zanchi, NE | 1 |
| Holecek, M; Kovarik, M; Muthny, T; Sispera, L | 1 |
| Bogusiewicz, A; Boysen, G; Dawson, AM; Henrich, CL; Horvath, TD; Matthews, NI; Mock, DM; Moran, JH; Owen, SN; Spencer, HJ; Stratton, SL | 1 |
| de Almeida, IT; Diogo, L; Duran, M; Garcia, P; IJlst, L; Luís, PB; Ruiter, JP; Silva, MF; Wanders, RJ | 1 |
| Atherton, PJ; Breen, L; Churchward-Venne, TA; Crossland, H; Etheridge, T; Hill, DS; Hossain, T; Loughna, P; Phillips, BE; Phillips, SM; Rathmacher, JA; Smith, K; Szewczyk, NJ; Wilkinson, DJ; Williams, J | 1 |
| Barillaro, C; Landi, F; Liperoti, R; Martone, AM; Onder, G | 1 |
| Aoki, MS; Artioli, GG; Baptista, IL; Guilherme, JP; Leal, ML; Miyabara, EH; Moriscot, AS; Silva, WJ | 1 |
| Boutry, C; Davis, SR; Davis, TA; El-Kadi, SW; Nguyen, HV; Orellana, RA; Suryawan, A; Wheatley, SM | 1 |
| Bruckbauer, A; Zemel, MB | 1 |
| Barranco, A; Navalón, A; Ramírez, M; Rueda, R; Santos-Fandila, A; Zafra-Gómez, A | 1 |
| Brett, SJ; Frost, G; Hickson, M; Wandrag, L | 1 |
| Caudill, MA; Gayle, A; Jiang, X; Lucas, LK; Malysheva, O; Perry, CA; West, AA; Yan, J | 1 |
| Beno, DW; Edens, NK; Lee, AJ; Mason, M; Mason-Bright, T; Shapiro, R; Surber, B; Zhang, X | 1 |
| Mizuno, S; Saika, A; Tsuge, T; Ushimaru, K | 1 |
| Bueno-Vargas, P; López-Pedrosa, JM; Ramírez, M; Santos-Fandila, A; Zafra-Gómez, A | 1 |
| Phillips, SM | 1 |
| Balakrishnan, G; Pereira, SL; Puthan, JK; Ramesh, S; Reddy, MT; Shreeram, S; Subramanian, R | 1 |
| Jayakumar, J; Kuriyan, R; Kurpad, AV; Lokesh, DP; Philip, MG; Selvam, S; Shreeram, S | 1 |
| Bach, E; Hansen, J; Jensen, E; Jessen, N; Johannsen, M; Jørgensen, JO; Møller, AB; Møller, N; Richelsen, B; Rittig, N; Serena, A; Thomsen, HH | 1 |
| Bacci, ML; Barone, F; Elmi, A; Laghi, L; Romagnoli, N; Ventrella, D | 1 |
| Gerlinger-Romero, F; Guimarães-Ferreira, L; Nunes, MT; Salgueiro, RB; Yonamine, CY | 1 |
| Cruz-Jentoft, AJ | 1 |
| Brown, AD; Close, GL; Sharples, AP; Stewart, CE | 1 |
| Chen, X; Duan, Y; Guo, Q; Li, F; Wang, W; Wen, C; Yin, Y; Zhang, L | 1 |
| Buddington, KK; Buddington, RK; Howard, SC; Lee, HW | 1 |
| Duan, YH; Guo, QP; Kong, XF; Li, FN; Wang, WL; Xu, K; Zeng, LM; Zhang, LY | 1 |
| Jakubowski, JS; McGlory, C; Morton, RW; Murphy, KT; Noguchi, KS; Nunes, EA; Phillips, SM; Vandeweerd, JK; Wong, EPT | 1 |
| Calvani, R; Landi, F; Marzetti, E; Picca, A | 1 |
| Deng, J; Duan, Y; Li, F; Zeng, L; Zhong, Y | 1 |
| Deng, J; Duan, Y; Kong, X; Li, F; Song, B; Zheng, C; Zhong, Y | 1 |
| Alves, F; Matias, CN; Monteiro, CP; Morton, RW; Phillips, SM; Reis, JF; Sardinha, LB; Teixeira, FJ; Valamatos, MJ | 1 |
| Holeček, M; Vodeničarovová, M | 1 |
| Duan, Y; Kong, X; Li, F; Song, B; Xu, K; Zheng, C; Zhong, Y | 1 |
| Banfield, L; Jakubowski, JS; Morton, RW; Nunes, EA; Phillips, SM; Teixeira, FJ; Vescio, V | 1 |
| Bautmans, I; Beckwée, D; De Breucker, S; Delaere, A; Gielen, E; Vandewoude, M | 1 |
| Baganz, F; Gao, M; Gu, J; Hao, J; Kostas, ET; Lu, X; Lye, GJ; Shi, J; Sun, S; Wang, Y; Yang, Y; Zhang, Z | 1 |
| Gao, R; Li, Z | 1 |
| Bear, DE; Rooyackers, O | 1 |
| Atherton, PJ; Chew, STH; Gonzalez, MC; Landi, F; Molinger, J; Prado, CM; Ruck, T | 1 |
15 review(s) available for valerates and leucine
| Article | Year |
|---|---|
Organic acidemias.
Topics: Acidosis, Renal Tubular; Acids; Amino Acid Metabolism, Inborn Errors; Amino Acids, Essential; Ammonia; Child; Diagnosis, Differential; Glutarates; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Leucine; Ligases; Methylmalonic Acid; Prenatal Diagnosis; Propionates; Pyruvates; Urea; Valerates | 1976 |
[Congenital metabolic acidosis in the postnatal period].
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Fructose-1,6-Diphosphatase Deficiency; Glutarates; Glycogen Storage Disease Type I; Humans; Hyperglycemia; Infant, Newborn; Isoleucine; Ketosis; Lactates; Leucine; Leukoencephalitis, Acute Hemorrhagic; Methylmalonic Acid; Propionates; Syndrome; Thiamine; Valerates; Valine | 1978 |
Molecular basis of isovaleric acidemia and the study of the acyl-CoA dehydrogenase family.
Topics: Acyl-CoA Dehydrogenases; Animals; DNA; Hemiterpenes; Humans; Infant, Newborn; Isovaleryl-CoA Dehydrogenase; Leucine; Mitochondria, Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentanoic Acids; Phenotype; Protein Biosynthesis; Protein Processing, Post-Translational; Rats; Valerates | 1988 |
Inborn errors of organic acid metabolism.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Biotin; Carboxylic Acids; Chromatography, Gas; Coenzyme A; Crotonates; Female; Gestational Age; Humans; Hydroxy Acids; Hydroxybutyrates; Infant; Infant, Newborn; Isomerases; Leucine; Male; Malonates; Metabolism, Inborn Errors; Pedigree; Pregnancy; Prenatal Diagnosis; Propionates; Pyrrolidonecarboxylic Acid; Valerates; Vitamin B 12 | 1974 |
Dietary supplements and the promotion of muscle growth with resistance exercise.
Topics: Anabolic Agents; Boron; Chromium; Creatine; Dehydroepiandrosterone; Dietary Carbohydrates; Dietary Proteins; Dietary Supplements; Glutamine; Humans; Leucine; Muscle Development; Muscle, Skeletal; Nutritional Physiological Phenomena; Protein Biosynthesis; Testosterone; Valerates; Vanadium Compounds; Weight Lifting | 1999 |
HMB supplementation: clinical and athletic performance-related effects and mechanisms of action.
Topics: Administration, Oral; Adult; Athletic Performance; Body Composition; Dietary Supplements; Humans; Keto Acids; Leucine; Male; Muscle Strength; Muscle, Skeletal; Resistance Training; Signal Transduction; Valerates | 2011 |
The new metabolic treatments for sarcopenia.
Topics: Animals; Humans; Leucine; Sarcopenia; Valerates; Vitamin D | 2013 |
Impact of supplementation with amino acids or their metabolites on muscle wasting in patients with critical illness or other muscle wasting illness: a systematic review.
Topics: Aged; Amino Acids; Amino Acids, Essential; Body Composition; Creatine; Critical Illness; Diet; Dietary Supplements; Enteral Nutrition; Female; Humans; Intensive Care Units; Leucine; Male; MEDLINE; Muscular Atrophy; Nutritional Status; Valerates | 2015 |
Nutritional supplements in support of resistance exercise to counter age-related sarcopenia.
Topics: Aged; Aging; Creatine; Diet; Dietary Proteins; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Leucine; Male; Muscle Strength; Muscle, Skeletal; Quality of Life; Resistance Training; Sarcopenia; Valerates | 2015 |
Beta-Hydroxy-Beta-Methyl Butyrate (HMB): From Experimental Data to Clinical Evidence in Sarcopenia.
Topics: Aged; Aged, 80 and over; Aging; Apoptosis; Cell Survival; Dietary Supplements; Frailty; Humans; Leucine; Middle Aged; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Sarcopenia; Valerates | 2018 |
Beta-hydroxy-beta-methylbutyrate and sarcopenia: from biological plausibility to clinical evidence.
Topics: Aged; Dietary Supplements; Frail Elderly; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Physical Functional Performance; Sarcopenia; Valerates | 2019 |
Supplementation with the Leucine Metabolite β-hydroxy-β-methylbutyrate (HMB) does not Improve Resistance Exercise-Induced Changes in Body Composition or Strength in Young Subjects: A Systematic Review and Meta-Analysis.
Topics: Adolescent; Adult; Body Composition; Body Mass Index; Databases, Factual; Dietary Supplements; Female; Humans; Leucine; Male; Muscle Strength; Muscle, Skeletal; Randomized Controlled Trials as Topic; Resistance Training; Sensitivity and Specificity; Valerates; Young Adult | 2020 |
Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses.
Topics: Aged; Aged, 80 and over; Amino Acids, Essential; Creatine; Dietary Supplements; Exercise; Humans; Leucine; Muscle Strength; Muscle, Skeletal; Physical Functional Performance; Sarcopenia; Valerates | 2021 |
HMB and leucine supplementation during critical illness and recovery.
Topics: Critical Illness; Dietary Supplements; Humans; Leucine; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Valerates | 2022 |
Advances in muscle health and nutrition: A toolkit for healthcare professionals.
Topics: Adult; Amino Acids; Amino Acids, Branched-Chain; COVID-19; Creatine; Delivery of Health Care; Dietary Supplements; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Hand Strength; Humans; Leucine; Malnutrition; Muscle Strength; Muscle, Skeletal; Valerates; Vitamin D | 2022 |
7 trial(s) available for valerates and leucine
| Article | Year |
|---|---|
Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training.
Topics: Adult; Body Composition; Body Weight; Diet; Dietary Fats; Dietary Proteins; Energy Metabolism; Humans; Leucine; Male; Methylhistidines; Muscle Proteins; Muscle, Skeletal; Physical Education and Training; Valerates; Weight Lifting | 1996 |
Effect of beta-hydroxy beta-methylbutyrate on the onset of blood lactate accumulation and V(O)(2) peak in endurance-trained cyclists.
Topics: Adult; Anaerobic Threshold; Analysis of Variance; Bicycling; Blood Glucose; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Exercise; Hematocrit; Hemoglobins; Humans; Lactates; Leucine; Male; Oxygen Consumption; Physical Education and Training; Physical Endurance; Time Factors; Valerates | 2001 |
Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
Topics: Adult; Biomarkers; Biotin; Carbon-Carbon Ligases; Carnitine; Choline; Chromatography, Liquid; Diet; Dietary Supplements; Female; Humans; Lactation; Leucine; Milk, Human; New York; Patient Compliance; Pregnancy; Tandem Mass Spectrometry; Valerates; Young Adult | 2014 |
Anabolic effects of leucine-rich whey protein, carbohydrate, and soy protein with and without β-hydroxy-β-methylbutyrate (HMB) during fasting-induced catabolism: A human randomized crossover trial.
Topics: Adaptor Proteins, Signal Transducing; Adult; Anabolic Agents; Body Mass Index; Cell Cycle Proteins; Cross-Over Studies; Dietary Carbohydrates; Fasting; Glucagon; Humans; Leucine; Male; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Soybean Proteins; TOR Serine-Threonine Kinases; Valerates; Whey Proteins; Young Adult | 2017 |
Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men.
Topics: Adult; Biopsy; Body Composition; Creatine Kinase; Dietary Supplements; Double-Blind Method; Human Growth Hormone; Humans; Hydrocortisone; Insulin-Like Growth Factor I; Leucine; Male; Muscle Strength; Muscle, Skeletal; Performance-Enhancing Substances; Resistance Training; Testosterone; Ultrasonography; Valerates; Young Adult | 2019 |
α-Ketoisocaproate and β-hydroxy-β-methyl butyrate regulate fatty acid composition and lipid metabolism in skeletal muscle of growing pigs.
Topics: AMP-Activated Protein Kinases; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Diet; Fatty Acids; Gene Expression Regulation; Keto Acids; Leucine; Lipid Metabolism; Muscle, Skeletal; Random Allocation; RNA, Messenger; Swine; TOR Serine-Threonine Kinases; Transcription Factors; Valerates | 2019 |
Leucine metabolites do not attenuate training-induced inflammation in young resistance trained men.
Topics: Adult; Biomarkers; Body Composition; C-Reactive Protein; Calcium; Caproates; Dietary Supplements; Double-Blind Method; Humans; Inflammation; Interleukin-6; Leucine; Male; Muscle Strength; Muscle, Skeletal; Resistance Training; Sports Nutritional Physiological Phenomena; Tumor Necrosis Factor-alpha; Valerates; Young Adult | 2019 |
155 other study(ies) available for valerates and leucine
| Article | Year |
|---|---|
Prenatal diagnosis and a case report of isovaleric acidaemia.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Chromatography, Gas; Female; Humans; Leucine; Male; Pedigree; Pregnancy; Prenatal Diagnosis; Valerates | 1978 |
[Emergency treatment of inborn amino errors of amino acid metabolism detected in the neonatal period].
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Diuretics, Osmotic; Emergencies; Enteral Nutrition; Exchange Transfusion, Whole Blood; Humans; Infant, Newborn; Leucine; Methylmalonic Acid; Peritoneal Dialysis; Propionates; Valerates | 1979 |
Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis.
Topics: Acetates; Acidosis; Animals; Child; Child, Preschool; Chromatography, Gas; Diabetes Mellitus; Diabetic Ketoacidosis; Glutarates; Humans; Hydroxy Acids; Hydroxybutyrates; Infant; Isoleucine; Leucine; Male; Mass Spectrometry; Rats; Streptozocin; Valerates; Valine | 1975 |
Leucine catabolism and CO2 fixation into fatty acids by Tetrahymena: evidence for two pools of CO2.
Topics: Acetates; Bicarbonates; Carbon Dioxide; Coenzyme A; Crotonates; Fatty Acids; Glycogen; Leucine; Ligases; Pyruvates; Tetrahymena pyriformis; Valerates | 1977 |
[Isovaleric acidemia combined with hypertrophic pylorstenosis (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Humans; Hypertrophy; Infant; Infant, Newborn; Leucine; Male; Pyloric Stenosis; Valerates | 1979 |
Glycine therapy in isovaleric acidemia.
Topics: Acidosis; Administration, Oral; Amino Acid Metabolism, Inborn Errors; Child, Preschool; Drug Administration Schedule; Female; Glycine; Humans; Keto Acids; Ketone Bodies; Lactates; Leucine; Pyruvates; Valerates | 1978 |
The metabolism of leucine by developing rat brain: effect of leucine and 2-oxo-4-methylvalerate on lipid synthesis from glucose and ketone bodies.
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebral Cortex; Female; Glucose; Keto Acids; Ketone Bodies; Leucine; Lipids; Male; Pregnancy; Rats; Valerates | 1978 |
Volatile acid production from threonine, valine, leucine and isoleucine by clostridia.
Topics: Acetates; Butyrates; Caproates; Clostridium; Fatty Acids, Volatile; Isoleucine; Leucine; Propionates; Species Specificity; Threonine; Valerates; Valine | 1978 |
[Isovaleric acidemia and beta-hydroxyisovaleric aciduria].
Topics: Amino Acid Metabolism, Inborn Errors; Humans; Infant; Infant, Newborn; Leucine; Valerates | 1978 |
The effects of growth hormone on the utilization of L-leucine in adipose tissue.
Topics: Adipose Tissue; Animals; Cycloheximide; Dactinomycin; Glucose; Growth Hormone; Hypophysectomy; Leucine; Male; Rats; Time Factors; Valerates | 1978 |
Kinetics of the early insulin response of the perfused rat pancreas to various metabolites and tolbutamide.
Topics: Animals; Caproates; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Rats; Stimulation, Chemical; Time Factors; Tolbutamide; Valerates | 1975 |
Leucine biosynthesis in the blue-green bacterium Anacystis nidulans.
Topics: 2-Isopropylmalate Synthase; Alcohol Oxidoreductases; Cell-Free System; Cyanobacteria; Dicarboxylic Acids; Hydro-Lyases; Leucine; Mutation; Valerates | 1975 |
Biosynthesis of rat kidney catalase. Double-labeling by [14C]leucine and delta-amino[3H]levulinic acid.
Topics: Aminolevulinic Acid; Animals; Carbon Radioisotopes; Catalase; Enzyme Induction; Immunodiffusion; Isotope Labeling; Kidney; Kinetics; Leucine; Precipitin Tests; Rats; Subcellular Fractions; Tritium; Urea; Valerates | 1976 |
Effect of dietary branched-chain alpha-keto acids on hepatic branched-chain alpha-keto acid dehydrogenase in the rat.
Topics: Animals; Body Weight; Caproates; Keto Acids; Ketone Oxidoreductases; Kidney; Leucine; Liver; Male; Muscles; Organ Size; Organ Specificity; Rats; Structure-Activity Relationship; Valerates; Valine | 1977 |
Site of action of insulin in promoting leucine utilization in adipose tissue.
Topics: Adipose Tissue; Animals; Carbon Dioxide; Chloramphenicol; Cycloheximide; Glucose; In Vitro Techniques; Insulin; Keto Acids; Leucine; Lipid Metabolism; Male; Oxidation-Reduction; Protein Biosynthesis; Puromycin; Rats; Valerates | 1977 |
Metabolism of [1-(14)C] and [2-(14)C] leucine in cultured skin fibroblasts from patients with isovaleric acidemia. Characterization of metabolic defects.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Amino Acid Metabolism, Inborn Errors; Carbon Dioxide; Cell Line; Cells, Cultured; Depression, Chemical; Fibroblasts; Flavin-Adenine Dinucleotide; Glycine; Humans; Leucine; Maple Syrup Urine Disease; Oxidation-Reduction; Skin; Succinates; Valerates; Valine | 1976 |
[Isovaleric acidemia. Study and treatment in 3 brothers].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Fatty Acids, Volatile; Female; Humans; Infant; Infant, Newborn; Leucine; Male; Oxidoreductases; Peritoneal Dialysis; Sweat; Valerates | 1976 |
Separate regulation of transport and biosynthesis of leucine, isoleucine, and valine in bacteria.
Topics: Acetolactate Synthase; Alcohol Oxidoreductases; Biological Transport, Active; Cell-Free System; Dicarboxylic Acids; Enzyme Repression; Escherichia coli; Genes, Regulator; Isoleucine; Leucine; Mutation; Protein Binding; Salmonella typhimurium; Valerates; Valine | 1975 |
Addition of leucine precursors to the diet of leucine-starved mice.
Topics: Animals; Bacteria; Caproates; Deficiency Diseases; Leucine; Mice; Structure-Activity Relationship; Valerates | 1975 |
Acute neonatal isovaleric acidemia. A report of two cases.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Leucine; Male; Pedigree; Valerates | 1975 |
Biosynthesis of liver catalase in rats treated with allylisopropylacetylcarbamide. II. Double-labeling of catalase with (14C)leucine and delta-(3H)aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Catalase; Leucine; Levulinic Acids; Liver; Microbodies; Microsomes, Liver; Rats; Ribosomes; Urea; Valerates | 1975 |
Biosynthesis of 2-methylalkanes in the crickets Nemobius fasciatus and Gryllus pennsylvanicus.
Topics: Acetates; Alkanes; Animals; Butyrates; Chromatography, Gas; Leucine; Orthoptera; Species Specificity; Valerates; Valine | 1976 |
Biotin deficiency in rats: disturbances of leucine metabolism are detectable early.
Topics: Animals; Biotin; Gas Chromatography-Mass Spectrometry; Leucine; Male; Rats; Rats, Inbred Strains; Valerates | 1992 |
The contribution of protein catabolism to metabolic decompensation in 3-hydroxy-3-methylglutaric aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Diseases in Twins; Female; Glutarates; Humans; Leucine; Male; Meglutol; Oxo-Acid-Lyases; Phenylalanine; Proteins; Valerates | 1990 |
Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta-methylbutyrate in vivo.
Topics: Animals; Female; Keto Acids; Leucine; Male; Osmolar Concentration; Oxidation-Reduction; Sheep; Swine; Valerates | 1992 |
Increased urinary excretion of beta-hydroxyisovaleric acid in ketotic and non-ketotic type II diabetes mellitus.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Gas Chromatography-Mass Spectrometry; Glycosuria; Humans; Leucine; Male; Middle Aged; Trimethylsilyl Compounds; Valerates | 1990 |
Analysis of beta-hydroxy-beta-methyl butyrate in plasma by gas chromatography and mass spectrometry.
Topics: Animals; Buffers; Caproates; Gas Chromatography-Mass Spectrometry; Leucine; Reference Standards; Sheep; Valerates | 1990 |
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency as detected by radiochemical assay in cell extracts by thin-layer chromatography, and identification of three new cases.
Topics: Cells, Cultured; Chromatography, Thin Layer; Dicarboxylic Acids; Fibroblasts; Humans; Infant; Infant, Newborn; Leucine; Lymphocytes; Male; Oxidation-Reduction; Oxo-Acid-Lyases; Radiochemistry; Valerates | 1990 |
Isovaleric acidemia: personal history, clinical survey and study of the molecular basis.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Cell Line; Child, Preschool; Female; Hemiterpenes; Humans; Isovaleryl-CoA Dehydrogenase; Leucine; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentanoic Acids; Prognosis; Valerates | 1990 |
The treatment of isovaleric acidemia with glycine supplement.
Topics: Carbon Dioxide; Cells, Cultured; Child; Child, Preschool; Female; Fibroblasts; Glycine; Hemiterpenes; Humans; Isovaleryl-CoA Dehydrogenase; Leucine; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentanoic Acids; Valerates | 1988 |
Acute and chronic-intermittent isovaleric acidemia: diagnosis and glycine therapy.
Topics: Acute Disease; Child; Child, Preschool; Chronic Disease; Female; Glycine; Hemiterpenes; Humans; Isovaleryl-CoA Dehydrogenase; Leucine; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentanoic Acids; Valerates | 1988 |
Effects of dietary leucine, alpha-ketoisocaproate and isovalerate on antibody production and lymphocyte blastogenesis in growing lambs.
Topics: Animals; Antibody Formation; Diet; Immunity, Cellular; Keto Acids; Leucine; Lymphocyte Activation; Lymphocytes; Sheep; Valerates | 1988 |
[Plasma level of branched-chain amino and keto acids in healthy subjects after an intravenous dose of MCT/LCT or LCT].
Topics: Adult; Amino Acids, Branched-Chain; Caproates; Fasting; Fat Emulsions, Intravenous; Female; Hemiterpenes; Humans; Infusions, Intravenous; Insulin; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Random Allocation; Triglycerides; Valerates; Valine | 1988 |
Protein origin of the volatile fatty acids isobutyrate and isovalerate in human stool.
Topics: Albumins; Butyrates; Fatty Acids, Volatile; Feces; Hemiterpenes; Humans; Hydrogen-Ion Concentration; Isobutyrates; Leucine; Male; Pentanoic Acids; Proteins; Valerates; Valine | 1987 |
Endogenous catabolism as source of toxic metabolites in isovaleric acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Dietary Proteins; Hemiterpenes; Humans; Leucine; Pentanoic Acids; Valerates | 1987 |
Isovaleryl-CoA dehydrogenase activity in isovaleric acidemia fibroblasts using an improved tritium release assay.
Topics: Amino Acid Metabolism, Inborn Errors; Cells, Cultured; Fibroblasts; Hemiterpenes; Humans; Isovaleryl-CoA Dehydrogenase; Kinetics; Leucine; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentanoic Acids; Skin; Tritium; Valerates | 1986 |
Endogenous catabolism is the major source of toxic metabolites in isovaleric acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Dietary Proteins; Glycine; Humans; Isovaleryl-CoA Dehydrogenase; Leucine; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Valerates | 1987 |
Biotin-responsive beta-methylcrotonylglycinuria.
Topics: Acidosis; Administration, Oral; Amino Acid Metabolism, Inborn Errors; Biotin; Butyrates; Carbon Dioxide; Carboxy-Lyases; Chromatography, Gas; Fatty Acids; Glycine; Humans; Infant; Leucine; Male; Partial Pressure; Valerates; Valine; Vomiting | 1971 |
Isovaleric acidemia: results of family study and dietary treatment.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Child; Child, Preschool; Developmental Disabilities; Diet Therapy; Fatty Acids; Female; Glycine; Humans; Infant, Newborn; Intellectual Disability; Intelligence Tests; Leucine; Male; Odorants; Pedigree; Valerates | 1973 |
Regulation of leucine catabolism in Pseudomonas putida.
Topics: Alcohol Oxidoreductases; Cell-Free System; Chromatography, Paper; D-Amino-Acid Oxidase; Enzyme Induction; Enzyme Repression; Glucose; Glutamates; Isoleucine; Ketones; Leucine; Ligases; Mutation; Oxidation-Reduction; Oxo-Acid-Lyases; Pseudomonas; Spectrophotometry; Stereoisomerism; Succinates; Transaminases; Valerates; Valine | 1974 |
Studies on the mechanism of L-leucine-and alpha-ketoisocaproic acid-induced insulin release from perifused isolated pancreatic islets.
Topics: Animals; Caproates; Chemical Phenomena; Chemistry; Female; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Leucine; Male; Mice; NADP; Obesity; Spectrometry, Fluorescence; Structure-Activity Relationship; Valerates | 1974 |
High-affinity uptake of (3H)gamma-aminobutyric acid into frog spinal cord slices.
Topics: Absorption; Alanine; Amines; Amino Acids, Diamino; Aminobutyrates; Animals; Anura; Dinitrophenols; Guanidines; Hydroxybutyrates; In Vitro Techniques; Iodoacetates; Kinetics; Leucine; Neurotransmitter Agents; Ouabain; Rana pipiens; Sodium; Spinal Cord; Sulfonic Acids; Synaptic Transmission; Temperature; Time Factors; Tritium; Valerates | 1974 |
Neonatal death associated with isovalericacidaemia.
Topics: Acidosis; Bicarbonates; Chromatography; Chromatography, Gas; Coenzyme A; Electrolytes; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Hemorrhage; Humans; Hypocalcemia; Infant Mortality; Infant, Newborn; Leucine; Male; Metabolism, Inborn Errors; Valerates | 1967 |
No evidence of isovalthinuria in isovaleric acidemia-- brief note.
Topics: Amino Acid Metabolism, Inborn Errors; Autoanalysis; Child, Preschool; Electrophoresis; Filtration; Humans; Leucine; Valerates | 1970 |
Regulation of glutamate dehydrogenase by histidine.
Topics: Acetates; Adenine Nucleotides; Amino Acids; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Dipeptides; Enzyme Activation; Fluorescence; Glutamate Dehydrogenase; Histidine; Kinetics; Leucine; Liver; Methylation; NAD; Urea; Valerates | 1971 |
Crystalline L-leucine dehydrogenase.
Topics: Alanine; Amino Acid Oxidoreductases; Amino Acids; Aminocaproates; Ammonium Sulfate; Bacillus; Chemical Precipitation; Chromatography; Chromatography, DEAE-Cellulose; Crystallization; Electrophoresis, Disc; Glutamates; Hydroxyapatites; Isoleucine; Leucine; Molecular Weight; NAD; Stereoisomerism; Ultracentrifugation; Valerates; Valine | 1971 |
Kinetic measurements with monocarboxylic acids as substrates and effectors of glutamate dehydrogenase.
Topics: Acetates; Alanine; Animals; Binding Sites; Carboxylic Acids; Cattle; Enzyme Activation; Glutamate Dehydrogenase; Glutamates; Kinetics; Leucine; Liver; NAD; Protein Binding; Ultracentrifugation; Valerates | 1972 |
[Kinetic studies on binding of effectors to glutamate-dehydrogenase].
Topics: Adenosine Diphosphate; Binding Sites; Chemical Phenomena; Chemistry; Glutamate Dehydrogenase; Glutamates; Glutarates; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Leucine; NAD; Ultracentrifugation; Valerates | 1972 |
Subcellular localization of the leucine biosynthetic enzymes in yeast.
Topics: Acyltransferases; Cell-Free System; Centrifugation, Density Gradient; Dicarboxylic Acids; Electron Transport Complex IV; Glucosephosphate Dehydrogenase; Isomerases; Leucine; Mitochondria; Osmosis; Oxidoreductases; Oxo-Acid-Lyases; Saccharomyces cerevisiae; Solubility; Spectrophotometry; Spheroplasts; Transaminases; Valerates | 1973 |
Mutual antagonism in the metabolism of D-valine and D-leucine and antagonism by their analogs.
Topics: Amino Acids; Animals; Caproates; D-Amino-Acid Oxidase; Depression, Chemical; Diet; Growth; Keto Acids; Leucine; Male; Rats; Stereoisomerism; Stimulation, Chemical; Valerates; Valine | 1969 |
Central vs. systemic neurotoxicity of hypoglycin (ackee toxin) and related substance in the cat.
Topics: Acetates; Animals; Blood Pressure; Butyrates; Carbon Dioxide; Cats; Cerebral Ventricles; Chemoreceptor Cells; Emetics; Hydrogen-Ion Concentration; Injections; Injections, Intravenous; Leucine; Medulla Oblongata; Plants; Pyruvates; Respiration; Syncope; Toxins, Biological; Valerates; Vomiting | 1974 |
New amino acid regulatory locus having unusual properties in heterozygous merodiploids.
Topics: Acyltransferases; Alleles; Amino Acids; Cell-Free System; Chromosome Mapping; Chromosomes, Bacterial; Culture Media; Dicarboxylic Acids; Diploidy; Drug Resistance, Microbial; Escherichia coli; Fluorine; Genes; Heterozygote; Hydro-Lyases; Leucine; Lyases; Mutation; Pyruvates; Recombination, Genetic; Threonine; Transduction, Genetic; Valerates | 1972 |
Leucine accumulation by isoleucine revertants of Serratia marcescens resistant to -aminobutyric acid: lack of both feedback inhibition and repression.
Topics: Acetyltransferases; Aminobutyrates; Dicarboxylic Acids; Enzyme Repression; Feedback; Hydro-Lyases; Isoleucine; Leucine; Mutation; Serratia marcescens; Valerates; Valine | 1973 |
Genetic fine structure of the leucine operon of Escherichia coli K-12.
Topics: Alcohol Oxidoreductases; Arabinose; Cell-Free System; Chromosome Mapping; Crosses, Genetic; Dicarboxylic Acids; Escherichia coli; Genetic Complementation Test; Leucine; Mutagens; Mutation; Nitrosoguanidines; Operon; Oxo-Acid-Lyases; Recombination, Genetic; Salmonella typhimurium; Transduction, Genetic; Valerates | 1973 |
Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback-resistant alpha-isopropylmalate synthases and its structural consequences.
Topics: Acetyl Coenzyme A; Binding Sites; Binding, Competitive; Caproates; Carbon Isotopes; Chromatography, Gel; Dialysis; Electrophoresis, Polyacrylamide Gel; Feedback; Hydrogen-Ion Concentration; Keto Acids; Kinetics; Leucine; Malates; Mutation; Oxo-Acid-Lyases; Protein Binding; Protein Conformation; Salmonella typhimurium; Spectrophotometry; Spectrophotometry, Ultraviolet; Valerates | 1973 |
Genetic analysis of the leucine region in Escherichia coli B-r: gene-enzyme assignments.
Topics: Acyltransferases; Arabinose; Cell-Free System; Chromosome Mapping; Conjugation, Genetic; Dicarboxylic Acids; Escherichia coli; Genes; Genetic Complementation Test; Isomerases; Leucine; Mutation; Oxidoreductases; Spectrophotometry; Stereoisomerism; Transduction, Genetic; Valerates | 1974 |
flrB, a regulatory locus controlling branched-chain amino acid biosynthesis in Salmonella typhimurium.
Topics: Amino Acids; Amino Acyl-tRNA Synthetases; Autoanalysis; Cell-Free System; Chromatography; Chromosome Mapping; Dicarboxylic Acids; Genes, Regulator; Hydro-Lyases; Isoleucine; Leucine; Lyases; Mutation; Oxo-Acid-Lyases; Pyruvates; RNA, Bacterial; RNA, Transfer; Salmonella typhimurium; Temperature; Threonine; Transduction, Genetic; Valerates; Valine | 1974 |
Evolution of a new gene substituting for the leuD gene of Salmonella typhimurium: characterization of supQ mutations.
Topics: Chromosome Mapping; Crosses, Genetic; Dicarboxylic Acids; Genes; Isomerases; Leucine; Models, Biological; Mutagens; Mutation; Nitrites; Proline; Salmonella; Salmonella typhimurium; Suppression, Genetic; Temperature; Transduction, Genetic; Valerates | 1974 |
Regulation of transaminase C synthesis in Escherichia coli: conditional leucine auxotrophy.
Topics: Culture Media; Escherichia coli; Genetic Linkage; Genetics, Microbial; Isoleucine; Leucine; Molecular Biology; Recombination, Genetic; Spectrophotometry, Infrared; Time Factors; Transaminases; Transduction, Genetic; Valerates | 1974 |
Regulation of branched chain amino acid transaminase formation during the growth of Pseudomonas fluorescens UK-1.
Topics: Butyrates; Caproates; Glutamates; Isoleucine; Leucine; Propionates; Pseudomonas; Pseudomonas fluorescens; Transaminases; Valerates; Valine | 1972 |
Formation of 2-oxoisovalerate dehydrogenase in Pseudomonas fluorescens.
Topics: Carbon Isotopes; Isoleucine; Keto Acids; Ketone Oxidoreductases; Leucine; Pseudomonas; Pseudomonas fluorescens; Valerates; Valine | 1972 |
Polypeptides. XXI. Synthesis of some sequential macromolecular polypeptolides of L-leucine and L-2-hydroxy-4-methylpentanoic acid.
Topics: Amino Acid Sequence; Hydroxylation; Leucine; Methylation; Oligopeptides; Valerates | 1972 |
Nutritional alteration of the fatty acid composition of a thermophilic Bacillus species.
Topics: Acetates; Bacillus; Butyrates; Chromatography, Gas; Culture Media; Fatty Acids; Hot Temperature; Isoleucine; Isomerism; Leucine; Valerates; Valine | 1973 |
Diagnosis of isovaleric acidemia in cultured fibroblasts.
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Carbon Radioisotopes; Cells, Cultured; Child; Child, Preschool; Female; Fibroblasts; Heterozygote; Humans; Infant, Newborn; Leucine; Pregnancy; Prenatal Diagnosis; Skin; Valerates | 1973 |
Child with a defect in leucine metabolism associated with beta-hydroxyisovaleric aciduria and beta-methylcrotonylglycinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Biotin; Creatinine; Crotonates; Glycine; Humans; Infant; Leucine; Male; Pentanols; Pneumonia; Valerates | 1973 |
Inhibition of alanine and aspartate aminotransferases by alpha-oxoderivatives of the branched-chain amino acids.
Topics: Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Azoles; Binding Sites; Brain; Caproates; Humans; Keto Acids; Kinetics; Leucine; Liver; Maple Syrup Urine Disease; Organ Specificity; Protein Binding; Pyridoxamine; Rats; Spectrophotometry, Ultraviolet; Transaminases; Valerates | 1974 |
Possibility of inborn defect in isovalericacidaemia involving altered enzyme specificity rather than total inactivity.
Topics: Alanine; Butyrates; Coenzyme A; Cyclopropanes; Humans; Kinetics; Leucine; Lipid Metabolism, Inborn Errors; Oxidoreductases; Plants; Toxins, Biological; Valerates | 1974 |
Biosynthesis of branched-chain amino acids in Schizosaccharomyces pombe: regulation of the enzymes involved in isoleucine, valine, and leucine synthesis.
Topics: Alcohol Oxidoreductases; Ascomycota; Cell-Free System; Chromatography, Gel; Culture Media; Hydro-Lyases; Hydrogen-Ion Concentration; Hydroxybutyrates; Isoleucine; Isomerases; Keto Acids; Kinetics; Lactates; Leucine; Malates; Oxo-Acid-Lyases; Pyruvates; Spectrophotometry; Spectrophotometry, Ultraviolet; Threonine; Transaminases; Valerates; Valine | 1974 |
Role of the leu-3 cistron in the regulation of the synthesis of isoleucine and valine biosynthetic enzymes of Neurospora.
Topics: Alcohol Oxidoreductases; Cell-Free System; Dicarboxylic Acids; Enzyme Repression; Feedback; Genes; Hydro-Lyases; Isoleucine; Leucine; Mutation; Neurospora; Oxo-Acid-Lyases; Threonine; Valerates; Valine | 1974 |
Distribution of the isopropylmalate pathway to leucine among diverse bacteria.
Topics: Alcohol Oxidoreductases; Bacteria; Cell-Free System; Dicarboxylic Acids; Leucine; Oxo-Acid-Lyases; Species Specificity; Valerates | 1974 |
Effects of maple syrup urine disease metabolites on mouse L-fibroblasts in vitro: a fine structural and biochemical study.
Topics: Animals; Caprylates; Carbon Radioisotopes; Cell Count; Cell Division; Chromatography, Thin Layer; Humans; Hydrogen-Ion Concentration; Isoleucine; Keto Acids; L Cells; Leucine; Maple Syrup Urine Disease; Mice; Microscopy, Electron; Time Factors; Tritium; Valerates | 1974 |
Cross-linking of Salmonella isopropylmalate synthesis with dimethyl suberimidate: evidence for antagonistic effects of leucine and acetyl-CoA on the guaternary structure.
Topics: Acyltransferases; Chemical Phenomena; Chemistry; Coenzyme A; Detergents; Dicarboxylic Acids; Electrophoresis; Imides; Kinetics; Leucine; Macromolecular Substances; Malates; Molecular Weight; Nitriles; Protein Denaturation; Salmonella typhimurium; Sulfuric Acids; Valerates | 1971 |
Alpha-isopropylmalate synthase from Salmonella typhimurium. Carboxypeptidase digestion studies of parent and feedback-insensitive enzymes.
Topics: Acyltransferases; Amino Acid Sequence; Amino Acids; Ammonium Sulfate; Arginine; Carboxypeptidases; Chemical Precipitation; Chromatography; Chromatography, Gel; Chromosome Mapping; Dicarboxylic Acids; Feedback; Genetics, Microbial; Hydroxyapatites; Leucine; Mutation; Salmonella typhimurium; Transduction, Genetic; Valerates; Valine | 1971 |
Alpha-isopropylmalate synthase from Salmonella typhimurium--amino acid composition, NH 2 -terminal analysis, and fingerprint analysis.
Topics: Acyltransferases; Amino Acids; Ammonium Sulfate; Carbon Isotopes; Chemical Precipitation; Chromatography; Chromatography, Gel; Chromatography, Paper; Cyanates; Dicarboxylic Acids; Electrophoresis, Disc; Electrophoresis, Paper; Hydroxyapatites; Isotope Labeling; Kinetics; Leucine; Peptides; Salmonella typhimurium; Serine; Sulfhydryl Compounds; Trypsin; Valerates | 1971 |
Alpha-isopropylmalate synthase from Salmonella typhimurium. Purification and properties.
Topics: Binding Sites; Caproates; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Dialysis; Edetic Acid; Electrophoresis, Disc; Feedback; Filtration; Hydrogen-Ion Concentration; Keto Acids; Kinetics; Leucine; Ligases; Mercury; Methods; Models, Biological; Salmonella typhimurium; Ultracentrifugation; Valerates | 1969 |
[On the biogenetic origin of the isovaleryl group of mammeisin (4-phenyl coumarin)].
Topics: Carbon Isotopes; Chromatography, Thin Layer; Coumarins; Crystallization; Leucine; Plants; Valerates | 1969 |
[The alpha-isopropylmalate synthetase of Hydrogenomonas H 16].
Topics: Acetates; Acyltransferases; Carbon Isotopes; Catalysis; Chromatography, Paper; Coenzyme A; Culture Media; Dicarboxylic Acids; Fluorometry; Hydrogen-Ion Concentration; Isoenzymes; Isoleucine; Keto Acids; Leucine; Mutation; Pseudomonas; Valerates; Valine | 1969 |
Antimetabolites produced by microorganisms. II. L-2-amino-4-pentynoic acid.
Topics: Amino Acids; Antimetabolites; Bacillus subtilis; Chromatography, Ion Exchange; Chromatography, Thin Layer; Culture Media; Depression, Chemical; Fermentation; Hydrolysis; Leucine; Magnetic Resonance Spectroscopy; Methionine; Oxidation-Reduction; Spectrophotometry; Streptomyces; Valerates | 1971 |
Fatty acid-requiring mutant of bacillus subtilis defective in branched chain alpha-keto acid dehydrogenase.
Topics: Bacillus subtilis; Butyrates; Caproates; Carbon Isotopes; Carboxylic Acids; Chemical Phenomena; Chemistry; Chromatography, Gas; Fatty Acids; Fluorine; Genetics, Microbial; Isoleucine; Keto Acids; Leucine; Mass Spectrometry; Mutation; Nitriles; Oxidoreductases; Valerates; Valine | 1971 |
Isovaleric and -methylbutyric acidemias induced by hypoglycin A: mechanism of Jamaican vomiting sickness.
Topics: Animals; Blood Glucose; Butyrates; Cyclopropanes; Fruit; Glutarates; Glycine; Leucine; Male; Plant Extracts; Rats; Valerates | 1972 |
Specificity of Aeromonas aminopeptidase toward amino acid amides and dipeptides.
Topics: Aeromonas; Alanine; Amides; Amino Acids; Aminocaproates; Aminopeptidases; Dipeptides; Glycine; Isoleucine; Kinetics; Leucine; Methionine; Phenylalanine; Structure-Activity Relationship; Tryptophan; Tyrosine; Valerates; Valine | 1972 |
Dietary treatment of an infant with isovaleric acidemia.
Topics: Acidosis; Diet Therapy; Fatty Acids; Humans; Infant; Leucine; Male; Valerates | 1972 |
Quantitative studies on nitrogen metabolism in the bovine rumen. The rate of proteolysis of casein and ovalbumin and the release and metabolism of free amino acids.
Topics: Amino Acids; Ammonia; Animals; Autoanalysis; Caseins; Cattle; Electrophoresis; Female; Half-Life; Isoleucine; Leucine; Lithium; Lysine; Nitrogen; Ovalbumin; Rumen; Valerates; Valine | 1972 |
Beta-methylcrotonyl-CoA carboxylase deficiency: a new metabolic error in leucine degradation.
Topics: Amino Acid Metabolism, Inborn Errors; Biotin; Bronchopneumonia; Butyrates; Carbon Dioxide; Carbon-Carbon Ligases; Chromatography, Gas; Diet Therapy; Female; Glycine; Humans; Infant; Leucine; Ligases; Mass Spectrometry; Neurologic Manifestations; Odorants; Pentanols; Valerates | 1972 |
Biosynthesis of triacylglycerols containing isovaleric acid.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Chromatography, Gas; Chromatography, Thin Layer; Coenzyme A; Dolphins; Fatty Acids; Kinetics; Leucine; Lipids; Stereoisomerism; Triglycerides; Valerates | 1972 |
A simplified method for the preparation of 14 C-labelled branched-chain -oxo acids.
Topics: Amino Acid Oxidoreductases; Caproates; Carbon Isotopes; Catalase; Chromatography, Thin Layer; Isoleucine; Isotope Labeling; Keto Acids; Leucine; Methods; Valerates; Valine | 1972 |
Alpha-isopropylmalate synthase from yeast: purification, kinetic studies, and effect of ligands on stability.
Topics: Acyltransferases; Cell Fractionation; Chemical Precipitation; Chromatography; Chromatography, Gel; Coenzyme A; Dicarboxylic Acids; Enzyme Activation; Feedback; Glycols; Hot Temperature; Hydrogen-Ion Concentration; Hydroxyapatites; Keto Acids; Kinetics; Leucine; Molecular Weight; Saccharomyces; Streptomycin; Sulfates; Valerates | 1972 |
Biosynthesis of the isovaleryl and senecioyl moieties of tropane alkaloids.
Topics: Alkaloids; Datura stramonium; Leucine; Plants; Plants, Medicinal; Plants, Toxic; Tropanes; Valerates; Valine | 1972 |
A rapid method for the quantitative analysis of short-chain fatty acids in serum or plasma.
Topics: Acetates; Amino Acid Metabolism, Inborn Errors; Butyrates; Caproates; Chromatography, Gas; Fatty Acids; Leucine; Methods; Propionates; Time Factors; Valerates | 1971 |
The dissimilation of leucine, isoleucine and valine to volatile fatty acids by adult Fasciola hepatica.
Topics: Acetates; Butyrates; Carbon Isotopes; Fasciola hepatica; Fatty Acids, Volatile; Glucose; Isoleucine; Leucine; Propionates; Valerates; Valine | 1971 |
Isovaleric acidemia: a new genetic defect of leucine metabolism.
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Butyrates; Caproates; Child, Preschool; Chromatography, Gas; Coenzyme A; Fatty Acids; Female; Humans; Leucine; Male; Propionates; Valerates | 1966 |
Hypoglycin A: a specific inhibitor of isovaleryl CoA dehydrogenase.
Topics: Acidosis; Alanine; Amino Acid Metabolism, Inborn Errors; Animals; Butyrates; Caproates; Carbon Dioxide; Carbon Isotopes; Carnitine; Chromatography, Gas; Coenzyme A; Cyclopropanes; In Vitro Techniques; Isoleucine; Leucine; Male; Oxidoreductases; Plant Poisoning; Rats; Valerates; Vomiting | 1971 |
Expression of the leucine operon.
Topics: Genes; In Vitro Techniques; Isomerases; Leucine; Ligases; Mutation; Oxidoreductases; Salmonella typhimurium; Valerates | 1966 |
Simple selection for end-product inhibitor-insensitive mutants in yeast.
Topics: Acyltransferases; Crosses, Genetic; Dicarboxylic Acids; Diploidy; Drug Resistance, Microbial; Genetics, Microbial; Leucine; Ligases; Mutation; Saccharomyces; Valerates | 1970 |
Ester and ether-linked lipids in the mandibular canal of a porpoise (Phocoena phocoena). Occurrence of isovaleric acid in glycerolipids.
Topics: Animals; Chromatography, Gas; Chromatography, Thin Layer; Dolphins; Esters; Ethers; Glycerol; Leucine; Lipid Metabolism; Mandible; Valerates | 1970 |
Carbon dioxide fixation in green sulphur bacteria.
Topics: Acetates; Bacteria; Carbon Dioxide; Citric Acid Cycle; Fluoroacetates; Glutarates; Glycolysis; Iodoacetates; Isoleucine; Leucine; Metabolism; Photosynthesis; Polysaccharides, Bacterial; Pyruvates; Quaternary Ammonium Compounds; Valerates; Valine | 1970 |
Branched chain amino acid aminotransferase. IV. Kinetics of the transamination reactions.
Topics: Amines; Animals; Caproates; Caprylates; Dicarboxylic Acids; Enzyme Activation; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kinetics; Leucine; Mercaptoethanol; Myocardium; Picolines; Swine; Transaminases; Valerates | 1970 |
Inhibition of alpha-oxoglutarate and pyruvate oxidation by alpha-oxoderivatives of leucine and valine in rat tissues.
Topics: Animals; Brain; Caproates; Citrates; Coenzyme A; Humans; Keto Acids; Ketoglutaric Acids; Kidney; Kinetics; Leucine; Malates; Maple Syrup Urine Disease; Metabolism; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxidoreductases; Pyruvates; Rats; Valerates; Valine; Vibration | 1970 |
Biosynthesis of long-chain hydrocarbons. II. Studies on the biosynthetic pathway in tobacco.
Topics: Acetates; Butyrates; Caproates; Caprylates; Carbon Isotopes; Chromatography, Thin Layer; Fatty Acids; Hydrocarbons; Isoleucine; Leucine; Lipid Metabolism; Nicotiana; Plants, Toxic; Valerates; Valine | 1968 |
Metabolism of amino acids in protein-calorie-deficient rats.
Topics: Alanine; Amino Acids; Animals; Caproates; Carbon Isotopes; Caseins; Coenzyme A; Deficiency Diseases; Glutamates; Leucine; Liver; Phenylalanine; Protein Biosynthesis; Protein Deficiency; Rats; Valerates | 1969 |
Amino acid and alpha-keto acid concentrations in plasma and blood of the liverless dog.
Topics: Amino Acids; Aminobutyrates; Animals; Blood; Caproates; Chromatography, Paper; Dogs; Hepatectomy; Isoleucine; Keto Acids; Ketoglutaric Acids; Lactates; Leucine; Methionine; Pyruvates; Valerates; Valine | 1965 |
Importance of the isovalerate carboxylation pathway of leucine biosynthesis in the rumen.
Topics: Animals; Carbon Isotopes; Cattle; Leucine; Oxidoreductases; Rumen; Valerates | 1966 |
[Accumulation of free extracellular amino acids by Pseudomonas liquefaciens].
Topics: Acids; Alanine; Amino Acids; Aminobutyrates; Ammonium Chloride; Chromatography; Fumarates; Lactates; Leucine; Levulinic Acids; Malates; Propionates; Pseudomonas; Succinates; Valerates; Valine | 1966 |
The isolation and identification of N-isovalerylglycine from urine of patients with isovaleric acidemia.
Topics: Acidosis; Amino Acids; Chemistry, Clinical; Child; Child, Preschool; Chromatography, Gas; Coenzyme A; Female; Humans; In Vitro Techniques; Leucine; Magnetic Resonance Spectroscopy; Male; Spectrum Analysis; Valerates | 1967 |
Alpha-hydroxy acid oxidases in subcellular fractions from rat kidney.
Topics: Amino Acids; Animals; Electrophoresis; Hydroxybutyrates; In Vitro Techniques; Isoleucine; Kidney; Lactates; Leucine; Methionine; Mitochondria; Oxidoreductases; Rats; Valerates | 1967 |
Isovaleric acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Humans; Infant, Newborn; Leucine; Odorants; Valerates | 1967 |
3-Hydroxy-3-methylglutaric aciduria.
Topics: Cells, Cultured; Female; Fibroblasts; Follow-Up Studies; Glutarates; Humans; Infant, Newborn; Leucine; Meglutol; Oxo-Acid-Lyases; Skin; Valerates | 1984 |
Glycine in acute management of isovalericacidaemia.
Topics: Amino Acid Metabolism, Inborn Errors; Female; Glycine; Humans; Infant; Leucine; Oxidoreductases; Valerates | 1980 |
Inherited 3-methylglutaconic aciduria in two brothers--another defect of leucine metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Glutarates; Humans; Hydro-Lyases; Leucine; Male; Meglutol; Speech Disorders; Valerates | 1982 |
Stable isotope dilution analysis of 3-hydroxyisovaleric acid in amniotic fluid: contribution to the prenatal diagnosis of inherited disorders of leucine catabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Amniocentesis; Amniotic Fluid; Carboxy-Lyases; Female; Humans; Leucine; Pregnancy; Prenatal Diagnosis; Valerates | 1984 |
The relationship between the branched chain amino acids and their alpha-ketoacids in maple syrup urine disease.
Topics: Amino Acids, Branched-Chain; Caproates; Child; Child, Preschool; Female; Hemiterpenes; Humans; Infant; Infant, Newborn; Keto Acids; Leucine; Male; Maple Syrup Urine Disease; Valerates; Valine | 1984 |
The identification and the excretion pattern of isovaleryl glucuronide in the urine of patients with isovaleric acidemia.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Glucuronates; Glycine; Humans; Isovaleryl-CoA Dehydrogenase; Leucine; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Valerates | 1984 |
Release of leucine and isoleucine metabolites by perfused skeletal muscle and liver of rat.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Female; Hydroxybutyrates; Isoleucine; Keto Acids; Lactates; Lactic Acid; Leucine; Liver; Muscles; Rats; Rats, Inbred Strains; Valerates | 1983 |
[Isovaleric aciduria].
Topics: Amino Acid Metabolism, Inborn Errors; Hemiterpenes; Humans; Infant; Infant, Newborn; Leucine; Male; Pentanoic Acids; Valerates | 1983 |
Partial purification and characterization of two enzymes involved in isovaleric acid synthesis in Clostridium bifermentans.
Topics: Carboxy-Lyases; Chromatography, Gel; Chromatography, Ion Exchange; Clostridium; Deamination; Flavin-Adenine Dinucleotide; Hemiterpenes; Hydrogen-Ion Concentration; Keto Acids; Leucine; Molecular Weight; Pentanoic Acids; Transaminases; Valerates | 1983 |
Organic aciduria associated with isovaleric acidemia.
Topics: Acidosis; Gas Chromatography-Mass Spectrometry; Hemiterpenes; Humans; Infant; Leucine; Pentanoic Acids; Valerates | 1983 |
Organic acidurias: approach, results and clinical relevance.
Topics: Child; Child, Preschool; Crotonates; Female; Gas Chromatography-Mass Spectrometry; Glutarates; Humans; Infant; Keto Acids; Leucine; Ligases; Male; Metabolism, Inborn Errors; Oxidoreductases; Oxo-Acid-Lyases; Pregnancy; Prenatal Diagnosis; Valerates | 1982 |
Gas-chromatographic/mass spectrometric detection of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in double first cousins.
Topics: Amino Acid Metabolism, Inborn Errors; Female; Gas Chromatography-Mass Spectrometry; Glutarates; Humans; Hydroxy Acids; Infant; Leucine; Male; Meglutol; Oxo-Acid-Lyases; Valerates | 1982 |
Comparative utilization of the alpha-keto and D- and L-alpha-hydroxy analogs of leucine, isoleucine and valine by chicks and rats.
Topics: Animals; Caproates; Chickens; Hemiterpenes; Isoleucine; Keto Acids; Leucine; Male; Pentanoic Acids; Rats; Species Specificity; Structure-Activity Relationship; Valerates; Valine | 1982 |
Changing plasma and urinary organic acid levels in a patient with isovaleric acidemia during an attack.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Female; Glycine; Hemiterpenes; Humans; Hydroxybutyrates; Leucine; Pentanoic Acids; Valerates | 1982 |
[Isovaleric acidemia: identical biochemical picture in 3 patients with variable clinical manifestations].
Topics: Amino Acid Metabolism, Inborn Errors; Cells, Cultured; Child; Child, Preschool; Female; Fibroblasts; Glycine; Hemiterpenes; Humans; Infant; Infant, Newborn; Leucine; Male; Oxidation-Reduction; Pentanoic Acids; Valerates | 1982 |
4-hydroxyisovaleric acid: a new metabolite in isovaleric acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Humans; Leucine; Valerates | 1981 |
The pancytopenia of isovaleric acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Bone Marrow Examination; Female; Hematopoietic Stem Cells; Hemiterpenes; Humans; Infant, Newborn; Leucine; Male; Pancytopenia; Pentanoic Acids; Valerates | 1980 |
Alpha-keto and alpha-hydroxy branched-chain acid interrelationships in normal humans.
Topics: Adult; Amino Acids, Branched-Chain; Dietary Proteins; Evaluation Studies as Topic; Fasting; Female; Hemiterpenes; Humans; Isoleucine; Keto Acids; Leucine; Male; Mass Spectrometry; Oxidation-Reduction; Protein Binding; Time Factors; Valerates; Valine | 1993 |
Ketogenic flux from lipids and leucine, assessment in 3-hydroxy-3-methylglutaryl CoA lyase deficiency.
Topics: Carnitine; Child; Humans; Ketone Bodies; Leucine; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Oxo-Acid-Lyases; Valerates | 1995 |
Characterization of plasma acylcarnitines in patients under valproate monotherapy using ESI-MS/MS.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carnitine; Female; Humans; Leucine; Male; Middle Aged; Mitochondrial Trifunctional Protein; Multienzyme Complexes; Spectrometry, Mass, Electrospray Ionization; Valerates; Valproic Acid | 2001 |
A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria.
Topics: Bacterial Proteins; Cloning, Molecular; Coenzyme A; DNA; Fatty Acids; Leucine; Magnetic Resonance Spectroscopy; Methacrylates; Models, Chemical; Stigmatella aurantiaca; Thiazoles; Valerates | 2002 |
Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge.
Topics: Adult; Biotin; Diet; Dose-Response Relationship, Drug; Egg White; Female; Humans; Leucine; Male; Time Factors; Valerates | 2002 |
NMR spectroscopic studies on the late onset form of 3-methylglutaconic aciduria type I and other defects in leucine metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Female; Glutarates; Humans; Leucine; Magnetic Resonance Spectroscopy; Meglutol; Middle Aged; Valerates | 2006 |
Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana.
Topics: Amino Acid Sequence; Animals; Beauveria; Catalytic Domain; Cloning, Molecular; Depsipeptides; Fungal Proteins; Gene Silencing; Gene Targeting; Insecta; Insecticides; Leucine; Molecular Sequence Data; Peptide Synthases; Peptides, Cyclic; Protein Structure, Tertiary; Sequence Analysis; Survival Analysis; Valerates; Virulence Factors | 2009 |
Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain.
Topics: Animals; Brain; Central Nervous System Agents; Electron Transport; Homeostasis; Keto Acids; Ketoglutarate Dehydrogenase Complex; Leucine; Maple Syrup Urine Disease; Membrane Potential, Mitochondrial; Mitochondrial Diseases; Mitochondrial Swelling; NADP; Oxygen Consumption; Prosencephalon; Rats; Rats, Wistar; Valerates | 2010 |
Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats.
Topics: Animals; Cathepsin B; Cathepsin L; Leucine; Lysosomes; Male; Muscle, Skeletal; Oxygen; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Sepsis; Time Factors; Valerates | 2010 |
Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans.
Topics: Adult; Biotin; Carnitine; Cohort Studies; Female; Humans; Leucine; Male; Valerates | 2011 |
Inhibition of 3-methylcrotonyl-CoA carboxylase explains the increased excretion of 3-hydroxyisovaleric acid in valproate-treated patients.
Topics: Biotinidase; Carbon-Carbon Ligases; Case-Control Studies; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Gas Chromatography-Mass Spectrometry; Humans; Inhibitory Concentration 50; Kinetics; Leucine; Liver; Metabolomics; Models, Chemical; Valerates; Valproic Acid | 2012 |
Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism.
Topics: Administration, Oral; Humans; Leucine; Male; Muscle, Skeletal; Protein Biosynthesis; Proteolysis; Tissue Distribution; Valerates; Young Adult | 2013 |
Leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions.
Topics: Animals; Dietary Supplements; Hindlimb Suspension; Leucine; Male; Muscle, Skeletal; Organ Size; Phosphatidylinositol 3-Kinases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Rats; Sarcopenia; Valerates | 2013 |
Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of β-hydroxy-β-methylbutyrate.
Topics: Animals; Animals, Newborn; Autophagy; Leucine; Muscle Proteins; Muscle, Skeletal; Peptide Initiation Factors; Phosphorylation; Protein Biosynthesis; Signal Transduction; Sus scrofa; TOR Serine-Threonine Kinases; Valerates | 2014 |
Synergistic effects of polyphenols and methylxanthines with Leucine on AMPK/Sirtuin-mediated metabolism in muscle cells and adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Caffeic Acids; Chlorogenic Acid; Ellagic Acid; Fatty Acids; Humans; Leucine; Mice; Muscle Cells; NAD; Oxidation-Reduction; Phosphodiesterase Inhibitors; Polyphenols; Protein Kinase Inhibitors; Resveratrol; Sirtuin 1; Stilbenes; Valerates; Xanthines | 2014 |
Quantitative determination of β-hydroxymethylbutyrate and leucine in culture media and microdialysates from rat brain by UHPLC-tandem mass spectrometry.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Cattle; Chromatography, High Pressure Liquid; Culture Media; Leucine; Microdialysis; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Valerates | 2014 |
A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dipeptides; Intestinal Absorption; Keto Acids; Leucine; Male; Mass Spectrometry; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Valerates | 2015 |
Genome-based analysis and gene dosage studies provide new insight into 3-hydroxy-4-methylvalerate biosynthesis in Ralstonia eutropha.
Topics: Bacterial Proteins; Cupriavidus necator; Gene Dosage; Gene Expression Regulation, Bacterial; Genome, Bacterial; Leucine; Valerates; Valine | 2015 |
Quantification of β-hydroxymethylbutyrate and leucine by ultrahigh performance liquid chromatography tandem mass spectrometry at different situations and stages of a rodent life.
Topics: Animals; Animals, Newborn; Brain Chemistry; Chromatography, High Pressure Liquid; Fasting; Female; Lactation; Leucine; Limit of Detection; Male; Milk; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry; Valerates | 2015 |
Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Aging; Animals; Dietary Supplements; Humans; Keto Acids; Leucine; Liver; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Valerates | 2016 |
The relationship of endogenous plasma concentrations of β-Hydroxy β-Methyl Butyrate (HMB) to age and total appendicular lean mass in humans.
Topics: Absorptiometry, Photon; Adolescent; Adult; Age Factors; Aged; Anthropometry; Body Composition; Child; Dietary Supplements; Female; Hand Strength; Humans; India; Leucine; Male; Middle Aged; Muscle, Skeletal; Valerates | 2016 |
Age-Related 1H NMR Characterization of Cerebrospinal Fluid in Newborn and Young Healthy Piglets.
Topics: Adenine; Animals; Animals, Newborn; Blood-Brain Barrier; Cerebrospinal Fluid; Creatinine; Crosses, Genetic; Female; Glutamine; Inositol; Leucine; Magnetic Resonance Spectroscopy; Metabolomics; Methylamines; Pentanoic Acids; Principal Component Analysis; Swine; Tyrosine; Valerates; Valine | 2016 |
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on the expression of ubiquitin ligases, protein synthesis pathways and contractile function in extensor digitorum longus (EDL) of fed and fasting rats.
Topics: Animals; Carrier Proteins; Fasting; Leucine; Ligases; Male; Muscle Contraction; Muscle, Skeletal; Phosphorylation; Rats; Rats, Wistar; Ubiquitin; Valerates | 2018 |
Murine myoblast migration: influence of replicative ageing and nutrition.
Topics: Animals; Cell Movement; Cells, Cultured; Cellular Senescence; Leucine; Mice; Muscle, Skeletal; Myoblasts; Nutritional Status; Signal Transduction; Valerates | 2017 |
β-Hydroxy-β-methyl Butyrate Is More Potent Than Leucine in Inhibiting Starvation-Induced Protein Degradation in C2C12 Myotubes.
Topics: Animals; Cell Line; Insulin; Keto Acids; Leucine; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Phosphatidylinositol 3-Kinases; Proteolysis; Proto-Oncogene Proteins c-akt; SKP Cullin F-Box Protein Ligases; TOR Serine-Threonine Kinases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases; Valerates | 2018 |
Growth Responses of Preterm Pigs Fed Formulas with Different Protein Levels and Supplemented with Leucine or β-Hydroxyl β-Methylbutyrate.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Birth Weight; Diet, High-Protein; Diet, Protein-Restricted; Dietary Proteins; Dietary Supplements; Female; Gestational Age; Leucine; Male; Nutritional Status; Parenteral Nutrition; Premature Birth; Sex Factors; Sus scrofa; Valerates; Weight Gain | 2018 |
β-hydroxy-β-methyl butyrate promotes leucine metabolism and improves muscle fibre composition in growing pigs.
Topics: Amino Acids, Branched-Chain; Animals; Butyrates; Dietary Supplements; Leucine; Muscle Fibers, Skeletal; Muscle, Skeletal; Swine; Valerates | 2018 |
β-hydroxy-β-methylbutyrate (HMB) improves mitochondrial function in myocytes through pathways involving PPARβ/δ and CDK4.
Topics: Animals; Cell Culture Techniques; Cyclin-Dependent Kinase 4; Humans; Leucine; Mitochondria; Muscle Cells; PPAR gamma; PPAR-beta; Signal Transduction; Valerates | 2019 |
Effects of beta-hydroxy-beta-methylbutyrate supplementation on skeletal muscle in healthy and cirrhotic rats.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Tetrachloride; Dietary Supplements; Leucine; Liver; Liver Cirrhosis; Muscle, Skeletal; Rats, Wistar; Valerates | 2019 |
Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes.
Topics: Animals; Leucine; Mice; Muscle Fibers, Skeletal; Proteolysis; Valerates | 2019 |
2,3-Dihydroxyisovalerate production by Klebsiella pneumoniae.
Topics: Biosynthetic Pathways; Butylene Glycols; Culture Media; Fermentation; Hydrogen-Ion Concentration; Industrial Microbiology; Klebsiella pneumoniae; Lactic Acid; Leucine; Oxygen; Valerates; Valine | 2020 |
Biosynthesis of 3-Hydroxy-3-Methylbutyrate from l-Leucine by Whole-Cell Catalysis.
Topics: Biocatalysis; Hemiterpenes; Leucine; Pentanoic Acids; Valerates | 2021 |