Protein | Taxonomy | valerates (IC50) | chlorpromazine (IC50) |
Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | | 1.3 |
Spike glycoprotein | Betacoronavirus England 1 | | 9.51 |
Replicase polyprotein 1ab | Betacoronavirus England 1 | | 9.51 |
Solute carrier family 22 member 1 | Homo sapiens (human) | | 4.3 |
Transmembrane protease serine 2 | Homo sapiens (human) | | 9.51 |
Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | | 0.85 |
Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | | 0.85 |
Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | | 3.4 |
5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | | 0.0052 |
Potassium channel subfamily K member 2 | Homo sapiens (human) | | 2.7 |
Tyrosine-protein kinase Fyn | Homo sapiens (human) | | 8.68 |
Procathepsin L | Homo sapiens (human) | | 9.51 |
Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | | 0.019 |
Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | | 0.652 |
Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | | 0.149 |
Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | | 0.025 |
Alpha-2A adrenergic receptor | Homo sapiens (human) | | 0.352 |
Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | | 9.51 |
Replicase polyprotein 1ab | Human coronavirus 229E | | 9.51 |
Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | | 9.51 |
Calmodulin-1 | Homo sapiens (human) | | 7.63 |
Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | | 9.51 |
Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | | 0.083 |
Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | | 5.8275 |
D(2) dopamine receptor | Homo sapiens (human) | | 0.0142 |
Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | | 0.031 |
Alpha-2B adrenergic receptor | Homo sapiens (human) | | 0.026 |
Alpha-2C adrenergic receptor | Homo sapiens (human) | | 0.374 |
D | Rattus norvegicus (Norway rat) | | 0.1414 |
D(3) dopamine receptor | Rattus norvegicus (Norway rat) | | 0.0416 |
5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | | 4.685 |
Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | | 1.4791 |
D(2) dopamine receptor | Bos taurus (cattle) | | 0.5328 |
Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | | 0.206 |
D(1A) dopamine receptor | Homo sapiens (human) | | 0.225 |
D(4) dopamine receptor | Homo sapiens (human) | | 1.365 |
Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | | 1.3 |
Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | | 1.4791 |
Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | | 1.4791 |
Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | | 0.031 |
Sodium-dependent noradrenaline transporter | Homo sapiens (human) | | 0.019 |
Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | | 1.4791 |
Histamine H2 receptor | Homo sapiens (human) | | 2.626 |
Alpha-1D adrenergic receptor | Homo sapiens (human) | | 0.004 |
D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | | 0.0416 |
Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | | 1.3 |
Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | | 1.3 |
5-hydroxytryptamine receptor 2A | Homo sapiens (human) | | 0.0036 |
5-hydroxytryptamine receptor 2C | Homo sapiens (human) | | 0.0052 |
5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | | 4.685 |
Trypanothione reductase | Trypanosoma cruzi | | 5.8 |
D(4) dopamine receptor | Rattus norvegicus (Norway rat) | | 0.0416 |
Sodium-dependent serotonin transporter | Homo sapiens (human) | | 0.0795 |
Melanocortin receptor 5 | Homo sapiens (human) | | 7.617 |
Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | | 4.5 |
Histamine H1 receptor | Homo sapiens (human) | | 0.0145 |
Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | | 1.3 |
D(3) dopamine receptor | Homo sapiens (human) | | 0.012 |
Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | | 4.3 |
Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | | 4.3 |
Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | | 1.3 |
5-hydroxytryptamine receptor 2B | Homo sapiens (human) | | 0.126 |
Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | | 0.031 |
5-hydroxytryptamine receptor 6 | Homo sapiens (human) | | 0.057 |
Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | | 9.51 |
D(2) dopamine receptor | Rattus norvegicus (Norway rat) | | 0.0365 |
Calmodulin | Bos taurus (cattle) | | 2.5 |
Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | | 1.3 |
Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | | 1.3 |
Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | | 1.3 |
Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | | 4.3 |
Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | | 3.4 |
Sodium-dependent dopamine transporter | Homo sapiens (human) | | 2.643 |
Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | | 1.3 |
Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | | 1.3 |
Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | | 0.85 |
Aldehyde oxidase | Homo sapiens (human) | | 0.57 |
Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | | 1.9602 |
Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | | 0.85 |
Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | | 0.85 |
Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | | 3.4 |
Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | | 3.4 |
Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | | 4.3 |
Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | | 0.85 |
Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | | 4.3 |
Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | | 1.3 |
Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | | 5.8275 |
Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | | 1.3 |
Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | | 0.85 |
Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | | 1.3 |
D | Bos taurus (cattle) | | 0.646 |
Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | | 4.3 |
Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | | 0.451 |
Angiotensin-converting enzyme 2 | Homo sapiens (human) | | 9.51 |
Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | | 4.3 |
Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | | 1.3 |
Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | | 4.3 |
Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | | 4.3 |
Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | | 4.3 |
Article | Year |
Gas-chromatographic methods for the study of chlorpromazine and some of its metabolities in human plasma.Psychopharmacology communications, 1976, Volume: 2, Issue:1
Topics: Chlorpromazine; Chromatography, Gas; Humans; Indicators and Reagents; Valerates | 1976 |
Pharmacology of M & B 18,706, a drug which selectively reduces decerebrate rigidity.British journal of pharmacology, 1974, Volume: 50, Issue:1
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Cats; Cerebellar Ataxia; Cerebellum; Chlorpromazine; Decerebrate State; Dextroamphetamine; Diazepam; Dimethylamines; Dogs; Electromyography; Ischemia; Locomotion; Muscle Relaxants, Central; Muscle Rigidity; Phenothiazines; Rats; Reflex; Spinal Cord; Tranquilizing Agents; Valerates | 1974 |
A comparison of the actions of some drugs on decerebrate rigidity, muscle spindle activity and alpha-adrenoceptors.British journal of pharmacology, 1974, Volume: 50, Issue:3
Topics: Animals; Blood Pressure; Cats; Chlorpromazine; Decerebrate State; Desipramine; Dimethylamines; Dose-Response Relationship, Drug; Methotrimeprazine; Muscle Rigidity; Muscle Spindles; Nictitating Membrane; Norepinephrine; Phenothiazines; Receptors, Adrenergic; Serotonin Antagonists; Structure-Activity Relationship; Valerates | 1974 |
The membrane concentrations of neutral and positive anesthetics (alcohols, chlorpromazine, morphine) fit the Meyer-Overton rule of anesthesia; negative narcotics do not.Biochimica et biophysica acta, 1972, Jan-17, Volume: 255, Issue:1
Topics: Alcohols; Anesthetics; Animals; Barbiturates; Carbon Isotopes; Cell Membrane; Chlorpromazine; Erythrocytes; Fatty Acids, Nonesterified; Guinea Pigs; Hemolysis; Humans; Membranes; Morphine; Nerve Endings; Phenols; Procaine; Rabbits; Sarcoplasmic Reticulum; Sulfur Isotopes; Synaptic Vesicles; Synaptosomes; Valerates | 1972 |
GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors.Journal of neurochemistry, 1971, Volume: 18, Issue:10
Topics: Aminobutyrates; Animals; Caproates; Carnitine; Centrifugation, Density Gradient; Cerebellum; Cerebral Cortex; Chlorpromazine; Cysteamine; Desipramine; Dithiothreitol; Ethylmaleimide; Haloperidol; Hippocampus; Imipramine; Ornithine; Pimelic Acids; Propionates; Rats; Spinal Cord; Sulfanilamides; Synaptic Vesicles; Taurine; Tritium; Valerates | 1971 |
Contribution of aromatic residue interactions to the stability of myoglobin. V. Enhancement by aromatic compounds of the rate of heat denaturation.Biophysical journal, 1970, Volume: 10, Issue:4
Topics: Animals; Benzoates; Binding Sites; Cetacea; Chemical Phenomena; Chemistry; Chlorpromazine; Hot Temperature; Kinetics; Myoglobin; Phenylbutyrates; Propionates; Protein Denaturation; Pyridinium Compounds; Valerates | 1970 |