valacyclovir and cyclopropanecarboxylic-acid

valacyclovir has been researched along with cyclopropanecarboxylic-acid* in 1 studies

Other Studies

1 other study(ies) available for valacyclovir and cyclopropanecarboxylic-acid

Article	Year
Cyclopropanecarboxylic acid esters as potential prodrugs with enhanced hydrolytic stability. Organic letters, 2008, Feb-07, Volume: 10, Issue:3 Esters of cyclopropanecarboxylic acid demonstrate a substantial increase in stability under both acid- and base-catalyzed hydrolytic conditions. Comparison of the stability of valacyclovir 13 with the cyclopropane analogue 14 shows that at 40 degrees C and pH 6 the half-life of 14 is >300 h while the value for 13 is 69.7 h. CBS-QB3 calculations on isodesmic reactions for transfer of groups from an alkane to an ester show that a cyclopropyl group provides hyperconjugative stabilization. Topics: Acyclovir; Antiviral Agents; Cyclopropanes; Esters; Hydrolysis; Molecular Structure; Prodrugs; Valacyclovir; Valine	2008

Article

Year

Cyclopropanecarboxylic acid esters as potential prodrugs with enhanced hydrolytic stability.

Organic letters, 2008, Feb-07, Volume: 10, Issue:3

Esters of cyclopropanecarboxylic acid demonstrate a substantial increase in stability under both acid- and base-catalyzed hydrolytic conditions. Comparison of the stability of valacyclovir 13 with the cyclopropane analogue 14 shows that at 40 degrees C and pH 6 the half-life of 14 is >300 h while the value for 13 is 69.7 h. CBS-QB3 calculations on isodesmic reactions for transfer of groups from an alkane to an ester show that a cyclopropyl group provides hyperconjugative stabilization.

Topics: Acyclovir; Antiviral Agents; Cyclopropanes; Esters; Hydrolysis; Molecular Structure; Prodrugs; Valacyclovir; Valine

2008