vacidin-a and fungimycin

vacidin-a has been researched along with fungimycin* in 1 studies

Other Studies

1 other study(ies) available for vacidin-a and fungimycin

ArticleYear
Relationship between ionophoric and haemolytic activities of perimycin A and vacidin A, two polyene macrolide antifungal antibiotics.
    Biochemical pharmacology, 1989, Jun-01, Volume: 38, Issue:11

    The ionophoric and hemolytic activities of two antifungal aromatic heptaenes: vacidin A and perimycin A, were studied on human red blood cells. Measurements of hemolysis, K+ influx and efflux, H+ movement and potential difference across the cell membrane, show that the hemolytic activity, being related to the K+ permeability induced by the polyene, is strongly dependent on the ability of this polyene to induce H+ movement. It was shown that: (1) both antibiotics have approximately the same efficiency in inducing K+ permeability, but a 100-fold difference in their hemolytic activity; (2) their hemolytic activity is related to their ability to induce H+ movement; (3) the protonophoric activity requires the existence of a free carboxyl group in the macrolide ring, as in vacidin A. The hemolytic activity is determined by the intrinsic efficiency of a K+/H+ exchange induced by this polyene. With perimycin A, which lacks the free carboxyl group, the hemolytic activity is dependent on the Cl- conductive flux which slows down the K+ flux.

    Topics: Acetophenones; Antifungal Agents; Candicidin; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane Permeability; Erythrocyte Volume; Erythrocytes; Hemolysis; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Ionophores; Potassium; Time Factors

1989