ustiloxin-b and aflatrem

In Aspergillus flavus, laeA affects cell morphology and contributes to the production of secondary metabolites (SMs) production including aflatoxin, cyclopiazonic acid, and aflatrem. Here, we investigated the function of this transcription factor by performing proteomics analysis of the wild-type (WT) and ΔlaeA mutant growing on corn. Notably, our proteomics profile confirmed the functions of extracellular hydrolases, conidial hydrophobin, and response to oxidative stress during the induction of aflatoxin biosynthesis regulated by laeA. Unexpectedly, deletion of laeA resulted in the significant upregulation of the NAD

Topics: Aflatoxins; Aspergillus flavus; Chromatin Assembly and Disassembly; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Histone Deacetylases; Hydrolases; Indoles; Methyltransferases; Oxidative Stress; Peptides, Cyclic; Proteomics; Spores, Fungal; Transcription Factors; Zea mays