Page last updated: 2024-08-24

ursolic acid and betulinic acid

ursolic acid has been researched along with betulinic acid in 116 studies

Research

Studies (116)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.86)	18.7374
1990's	4 (3.45)	18.2507
2000's	28 (24.14)	29.6817
2010's	73 (62.93)	24.3611
2020's	10 (8.62)	2.80

Authors

Authors	Studies
Cosentino, LM; Hashimoto, A; Ikeshiro, Y; Kashiwada, Y; Lee, KH; Nagao, T; Okabe, H	1
Hata, K; Hori, K; Takahashi, S	1
Broedel, SE; Cihlar, RL; ElSohly, HN; Ferreira, D; Jacob, MR; Joshi, AS; Khan, IA; Khan, SI; Li, XC; Raulli, RE; Walker, LA; Zhang, Z	1
Cuong, NM; Fong, HH; Hoang, VD; Hung, NV; Pezzuto, JM; Soejarto, DD; Tan, GT; Zhang, HJ	1
Johnson, RK; Kingston, DG; Prakash Chaturvedula, VS; Schilling, JK	1
Fong, HH; Mesecar, AD; Nguyen, MC; Nguyen, QC; Nguyen, VH; Pezzuto, JM; Santarsiero, BD; Soejarto, DD; Tan, GT	1
Franzblau, SG; Gu, JQ; Montenegro, G; Timmermann, BN; Wang, Y	1
Ando, M; Fu, L; Hasegawa, T; Hirose, K; Kataoka, T; Kiuchi, M; Li, N; Mitsui, T; Oka, S; Sakai, J; Wang, J; Zhang, S; Zhao, M	1
Habib-Jiwan, JL; Hoet, S; Muccioli, GG; Opperdoes, FR; Pieters, L; Quetin-Leclercq, J	1
Alexacou, KM; Cheng, K; Gimisis, T; Hao, J; Hayes, JM; Leonidas, DD; Liu, J; Ni, P; Oikonomakos, NG; Sun, H; Wen, X; Zhang, L; Zhang, P; Zographos, SE	1
Chadwick, LR; Franzblau, SG; Jaki, BU; Lankin, DC; Pauli, GF; Wang, Y; Zhang, F	1
Abdel Bar, FM; Ahmad, KF; Bachawal, SV; El Sayed, KA; Sylvester, PW; Zaghloul, AM	1
Bae, K; Ha, do T; Ngoc, TM; Nhiem, NX; Thu, NB; Tuan, DT; Yim, N	1
Auwerx, J; Boudjelal, G; Genet, C; Lobstein, A; Saladin, R; Schmidt, C; Schoonjans, K; Souchet, M; Strehle, A; Wagner, A	1
Carcache de Blanco, EJ; Chai, H; Farnsworth, NR; Kardono, LB; Kinghorn, AD; Ren, Y; Riswan, S; Soejarto, DD	1
Chen, J; Chen, L; Cheng, K; Gong, Y; Hao, J; Jiang, H; Li, H; Li, L; Liang, Z; Liu, H; Liu, J; Luo, C; Sun, H; Wen, X; Zhang, L; Zhang, P; Zhang, X; Zheng, M; Zhu, X	1
El-Kabbani, O; Endo, S; Hara, A; Iinuma, M; Matsunaga, T; Soda, M; Tajima, K; Takemura, M; Zhao, HT	1
Gatbonton-Schwager, TN; Letterio, JJ; Tochtrop, GP	1
Chin, YW; Jee, JG; Jeong, YJ; Keum, YS; Kim, Y; Lee, J; Lee, JM; Yu, MS	1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P	1
Chen, K; Huang, X; Peng, Y; Qiu, Y; Shi, Y; Sun, D; Wang, H; Wang, Q; Xiao, S; Yu, F; Yu, M; Zhang, C; Zhang, L; Zhang, Z; Zhao, C; Zheng, Y; Zhou, D; Zhu, L	1
Cuong, NX; Jo, SH; Kim, YH; Kwon, YI; Luyen, BT; Minh, CV; Nam, NH; Tai, BH; Thao, NP; Yang, SY	1
Feng, Y; Mei, Z; Wang, C; Yang, G; Yang, J; Yang, X; Zhao, P; Zhou, Q	1
Cai, L; Jiang, S; Jiang, X; Li, J; Li, X; Liang, G; Liu, K; Lu, L; Na, H; Wang, C; Wang, Q; Xu, X; Yu, F; Zhang, T; Zhang, Z; Zheng, B	1
Ba Thi, C; D'hooghe, M; Dang Thi, TA; Doan Duy, T; Kim Tuyet, NT; Pham The, C; Thanh Nguyen, H; Van Nguyen, T	1
Fan, Z; Han, X; Jiao, P; Peng, Y; Wan, C; Wang, H; Wang, Q; Xiao, S; Xu, R; Yu, F; Zhang, L; Zhang, Y; Zhou, D; Zhou, X	1
Ahn, HC; Cho, SC; Choi, BY; Fei, X; Keum, YS; Kim, HJ; Lee, K; Seo, SY	1
Csuk, R; Heller, L; Wiemann, J	1
Cassera, MB; Dalal, S; Goetz, M; Kingston, DG; Su, Q	1
Csuk, R; Heller, L; Kuhfs, J; Sommerwerk, S	1
Li, X; Liu, K; Na, H; Wang, C; Zou, C	1
Csuk, R; Heller, L; Kerzig, C; Kramell, AE; Sommerwerk, S	1
Bailon-Moscoso, N; Castillo-Veintimilla, P; Romero-Benavides, JC; Ruano, AL; Silva-Rivas, R; Vivanco-Jaramillo, S	1
Alcaro, S; Corona, A; Cottiglia, F; Distinto, S; Floris, C; Fois, B; Maccioni, E; Malpure, NV; Meleddu, R; Sonar, VP; Tramontano, E	1
Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS	1
Cao, G; Chang, Y; Chen, D; He, X; Huang, X; Liu, J; Luo, H; Ni, S; Shen, Q; Sun, H; Wang, P; Wen, X; Zhou, H	1
Dong, YS; Sun, WL; Wen, C; Xing, Y; Xiu, ZL; Yu, XX; Zhang, BW	1
Baikova, IP; Giniyatullina, GV; Kataev, VE; Kazakova, OB; Lopatina, TV; Medvedeva, NI; Smirnova, IE	1
Anaya-Eugenio, GD; Burdette, JE; Chai, HB; Czarnecki, AA; de Blanco, EJC; Kinghorn, AD; Ninh, TN; Ren, Y; Soejarto, DD; Yuan, C	1
Efdi, M; Itoh, T; Katsurayama, K; Koketsu, M; Ninomiya, M	1
Appendino, G; Bellido, ML; Calzado, MA; Caprioglio, D; Cruz, C; Galera, N; Jinénez, C; Minassi, A; Muñoz, E; Prados, ME; Rogati, F	1
Borkova, L; Hodon, J; Kazakova, A; Pokorny, J; Urban, M	1
Brandes, B; Csuk, R; Fischer, L; Hoenke, S	1
Buckle, R; Eldridge, GR; Ellis, M; Garo, E; Hu, JF; Huang, Z; Lawrence, JA; Norman, VL; Rathinavelu, S; Starks, CM; Williams, RB	1
Awale, S; Dibwe, DF; Kim, MJ; Omar, AM; Sun, S; Tawila, AM; Toyooka, N; Ueda, JY	1
Chen, C; Cheng, K; Dai, L; Hu, K; Li, H; Liu, L; Sun, H; Wen, X; Xu, Q; Yuan, H	1
Bianchi, E; Cole, JR; Eckert, DJ; Trumbull, ER; Wiedhopf, RM	1
Fang, Z; Yang, Y; Zhou, G	1
Giner, RM; Gueho, J; Hostettmann, K; Julien, HR; Máñez, S; Recio, MC; Ríos, JL	1
Giner, RM; Máñez, S; Recio, MC; Ríos, JL	1
Kirby, GC; Simmonds, MS; Steele, JC; Warhurst, DC	1
Kim, YK; Ryu, SY; Yoon, SK	1
Biabani, MA; Kulshreshtha, DK; Kundu, B; Pathak, A; Puri, SK; Singh, SK; Srivastava, S	1
Chandramu, C; Dashavantha, RV; Krupadanam, DG; Manohar, RD	1
Baglin, I; Cavé, C; Lacaille-Dubois, MA; Mitaine-Offer, AC; Nour, M; Tan, K	1
Baglin, I; Cavé, C; Chauffert, B; Lacaille-Dubois, MA; Mitaine-Offer, AC; Nour, M; Poumaroux, A; Tan, K	1
Bérangère, C; Caussarieu, N; Lafosse, M; Morin, P; Morin-Allory, L	1
Becker, H; Hostanska, K; Scher, JM; Urech, K	1
Li, N; Li, X; Li, ZL; Wang, JH; Wang, Y; Xu, J; Zhang, P	1
Im, KR; Jeong, TS; Lee, WS; Park, YD; Sung, ND	1
Chang, CS; Chang, YS; Chao, DC; Chen, JC; Ho, TY; Hsiang, CY; Li, CC; Wu, SL	1
Bremner, JB; Chokchaisiri, R; Suksamrarn, A; Tanachatchairatana, T	1
Hao, J; Sun, H; Wen, X; Zhang, P	1
Duval, RE; Finance, C; Fontanay, S; Grare, M; Mayer, J	1
Jäger, S; Kopp, T; Laszczyk, MN; Scheffler, A; Trojan, H	1
Ahmad, AS; Mansour, AI; Nafady, AM; Ramadan, MA	1
Christensen, SB; Hansen, EW; Jäger, AK; Moesby, L; Saaby, L	1
Chen, YS; Lin, XY; Xie, JM; Yao, H; Zhang, YH	1
Li, GL; Song, CH; Suo, YR; Xia, L; You, JM; Zheng, J	1
Fukushima, EO; Mizutani, M; Muranaka, T; Ohyama, K; Ono, E; Saito, K; Seki, H; Umemoto, N	1
Nielsen, CH; Saaby, L	1
Chen, YJ; Cheng, SX; Kou, X; Long, Y; Wang, C; Wang, GH; Wang, WP	1
Gao, L; Lin, CZ; Zhao, ZX; Zhu, CC	1
He, C; Ma, G; Peng, Y; Wei, H; Xiao, P	1
David, JM; David, JP; e Silva, Mde L; Fontana, R; Lima, LS; Reis, PS; Santos, RA; Silva, LC	1
Cruz, LN; Garcia, CR; Gnoatto, SC; Gosmann, G; Innocente, AM; Moraes, MS; Nakabashi, M; Silva, GN; Sonnet, P	1
Bruni, R; Caligiani, A; Malavasi, G; Marseglia, A; Palla, G; Tognolini, M	1
Cruz, LN; da Silva, GN; de Moraes, MS; Garcia, CR; Gnoatto, SC; Gosmann, G; Graebin, C; Maria, NR; Nakabashi, M; Schuck, DC	1
Casanova, BB; Fuentefria, AM; Gnoatto, SC; Gosmann, G; Innocente, A; Klein, F; Lana, AD; Muniz, MN; Pereira, D; Sonnet, P	1
Casanova, BB; Frasson, AP; Gnoatto, SC; Gosmann, G; Innocente, AM; Tasca, T; Vieira, Pde B	1
Inn, KS; Jang, DS; Jo, SJ; Kim, HI; Kim, HJ; Kim, JE; Lee, CM; Lee, NR; Quan, FS	1
Bhadra, S; Chanda, J; Chaudhary, SK; Choudhury, S; Harwansh, R; Mukherjee, PK	1
He, QQ; Ma, CM; Ma, JN; Yang, L; Zhang, JY	1
Broniatowski, M; Flasiński, M; Hąc-Wydro, K	1
Bai, LY; Chiu, CF; Lin, WY; Weng, JR	1
Chen, G; Hu, N; Li, G; Liu, D; Liu, S; Suo, Y; Wu, H; You, J	1
Gaikwad, NB; Kshirsagar, PR; Nimbalkar, MS; Pai, SR	1
Andujar, S; Arena, ME; Bardón, A; Gilabert, M; Marcinkevicius, K; Schiavone, M	1
Bye, R; Flores-Bocanegra, L; Linares, E; Mata, R; Pérez-Vásquez, A; Torres-Piedra, M	1
Huang, GQ; Li, B; Lu, RM; Wei, JH; Zhong, ZG	1
Hegde, HV; Joshi, RK; Kholkute, SD; Pai, SR; Upadhya, V	1
Gray, CA; Johnson, JA; Li, H; Morrison, SA; Webster, D	1
Fu, HZ; Yan, QW; Zhang, TX; Zhong, RJ; Zhou, GP	1
da Silva, GN; Dos Santos, F; E Silva, AA; Gnoatto, SC; Gosmann, G; Trindade, FT	1
Bhattacharjee, D; Jagadeesh, B; Jain, N; Kavitha, R; Lakshmi, JK; Mallavadhani, UV; Pattnaik, B	1
Günther, G; Morales, J; Rodríguez, L; Valdés, K	1
Adamczyk-Grochala, J; Deregowska, A; Kwasniewicz, E; Lewinska, A; Wnuk, M	1
Adamczyk-Grochala, J; Bednarz, D; Lewinska, A; Wnuk, M	1
Irie, K; Kaido, Y; Kawabata, K; Kawakami, B; Kitamura, K; Matsuura, T; Murakami, S; Naruse, S; Ohigashi, H; Taira, S; Takahashi, M; Uemae, T	1
Ajiboye, HO; Ajiboye, TO; Oloyede, HOB; Salawu, MO	1
Ahn, SJ; Bang, IS; Cho, E; Choi, MH; Kim, JM; Kook, JK; Lim, YK; Park, SN	1
Chou, CH; Jhan, YL; Tsai, SJ; Wang, CM; Yeh, KL	1
Henao, IC; Pereañez, JA; Preciado, LM; Rey-Suárez, P	1
Ren, T; Xu, Z	1
Cui, CL; Liang, YN; Liao, ZX; Liu, HB; Liu, SJ; Tang, ZS; Zhang, Y	1
Al-Harrasi, A; Csuk, R; Fischer Née Heller, L; Kahnt, M	1
Arnason, JT; Dobson, CC; Durst, T; Foster, BC; Harris, CS; Liu, R; Sanchez, P	1
Kai, H; Matsuno, K; Mutoh, J; Nakamura, S; Nakashima, K; Tojoh, Y; Wada, M	1
Gnoatto, SCB; Macedo, AJ; Primon-Barros, M; Silva, GNSD	1
Cui, H; Jin, C; Jin, M; Li, G; Wang, J; Wang, R; Ye, C; Zhou, W; Zhou, Y	1
Gubaidullin, RR; Khalitova, RR; Nedopekina, DA; Spivak, AY	1
Garcia, AWA; Gnoatto, SCB; Kawano, DF; Krummenauer, ME; Lopes, W; Schrank, A; Vainstein, MH	1
Castro, MM; Duarte, IF; Duarte, MF; Guerra, ÂR; Oliveira, H; Paulino, AF	1
Croft, SL; Loiseau, PM; Pomel, S	1
Azevedo Dos Santos, AP; Baggio Gnoatto, SC; Berton Zanchi, F; Bioni Garcia Teles, C; de Almeida E Silva, A; de Souza Rodrigues, M; Soares de Maria de Medeiros, P; Sol Sol de Medeiros, D; Tasca Cargnin, S	1
Alhadrami, HA; Azhar, EI; Rateb, ME; Sayed, AM; Sharif, AM	1

Reviews

6 review(s) available for ursolic acid and betulinic acid

Article	Year
Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies. European journal of medicinal chemistry, 2017, Mar-31, Volume: 129 Topics: Anthelmintics; Humans; Medicine, Traditional; Phytotherapy; Plants, Medicinal	2017
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment. European journal of medicinal chemistry, 2017, Dec-15, Volume: 142 Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes	2017
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research. European journal of medicinal chemistry, 2019, Nov-15, Volume: 182 Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biomedical Research; Cell Proliferation; Drug Design; Humans; Neoplasms; Triterpenes; Viruses	2019
A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents. Mini reviews in medicinal chemistry, 2003, Volume: 3, Issue:6 Topics: Anti-HIV Agents; Antineoplastic Agents; Betulinic Acid; HIV-1; HT29 Cells; Humans; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured; Ursolic Acid	2003
Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments. Nanomedicine (London, England), 2016, Volume: 11, Issue:23 Topics: Animals; Antineoplastic Agents; Betulinic Acid; Biological Availability; Drug Delivery Systems; Drug Liberation; Humans; Nanocapsules; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Solubility; Triterpenes; Unilamellar Liposomes; Ursolic Acid; Water	2016
Chitosan Contribution to Therapeutic and Vaccinal Approaches for the Control of Leishmaniasis. Molecules (Basel, Switzerland), 2020, Sep-09, Volume: 25, Issue:18 Topics: Amphotericin B; Animals; Antimony; Antiprotozoal Agents; Betulinic Acid; Biocompatible Materials; Chitosan; Curcumin; Drug Carriers; Drug Compounding; Humans; Hydrogen-Ion Concentration; Leishmaniasis; Leishmaniasis Vaccines; Macrophages; Nanoparticles; Paromomycin; Pentacyclic Triterpenes; Polymers; Rifampin; Selenium; Thiomalates; Titanium; Triterpenes; Ursolic Acid	2020

Other Studies

110 other study(ies) available for ursolic acid and betulinic acid

Article	Year
Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. Journal of natural products, 2000, Volume: 63, Issue:12 Topics: Anti-HIV Agents; Cell Line; HIV-1; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Spectrometry, Mass, Fast Atom Bombardment; Triterpenes; Ursolic Acid	2000
Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line. Journal of natural products, 2002, Volume: 65, Issue:5 Topics: Animals; Apoptosis; Betulinic Acid; Cell Differentiation; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Melanoma, Experimental; Mice; Molecular Structure; Oxidation-Reduction; Pentacyclic Triterpenes; Pyridinium Compounds; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Triterpenes; Tumor Cells, Cultured	2002
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies. Journal of natural products, 2002, Volume: 65, Issue:12 Topics: Antifungal Agents; Candida albicans; Combretaceae; Cryptococcus neoformans; Enzyme Inhibitors; Fatty Acid Synthases; Inhibitory Concentration 50; Isoflavones; Melastomataceae; Molecular Structure; Moraceae; Paspalum; Plants, Medicinal; Saccharomyces cerevisiae; Structure-Activity Relationship; Tannins; Triterpenes	2002
Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. Journal of natural products, 2003, Volume: 66, Issue:2 Topics: Anti-HIV Agents; Chlorophyll; Ericales; Humans; Inhibitory Concentration 50; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Osteosarcoma; Plant Leaves; Plant Stems; Plants, Medicinal; Sesquiterpenes; Stereoisomerism; Triterpenes; Tumor Cells, Cultured; Vietnam	2003
New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata. Journal of natural products, 2003, Volume: 66, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Female; Guyana; Humans; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Ovarian Neoplasms; Plant Stems; Plants, Medicinal; Rubiaceae; Stereoisomerism; Triterpenes; Tumor Cells, Cultured	2003
New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. Journal of natural products, 2004, Volume: 67, Issue:6 Topics: Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Betulinic Acid; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Molecular Structure; Pentacyclic Triterpenes; Plant Leaves; Plants, Medicinal; Stereoisomerism; Strychnos; Triterpenes; Tumor Cells, Cultured	2004
Constituents of Senecio chionophilus with potential antitubercular activity. Journal of natural products, 2004, Volume: 67, Issue:9 Topics: Antitubercular Agents; Chile; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Toxic; Senecio; Sesquiterpenes; Stereoisomerism	2004
Three new triterpenes from Nerium oleander and biological activity of the isolated compounds. Journal of natural products, 2005, Volume: 68, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Screening Assays, Antitumor; Humans; Intercellular Adhesion Molecule-1; Japan; Models, Biological; Molecular Structure; Nerium; Oleanolic Acid; Plant Leaves; Plants, Medicinal; Triterpenes; Tumor Cells, Cultured	2005
Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. Journal of natural products, 2007, Volume: 70, Issue:8 Topics: Animals; Benin; Cell Line, Tumor; Molecular Structure; Plant Leaves; Plants, Medicinal; Sterols; Stigmasterol; Structure-Activity Relationship; Strychnos; Triterpenes; Trypanocidal Agents; Trypanosoma brucei brucei	2007
Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12 Topics: Adenosine Monophosphate; Allosteric Site; Animals; Binding Sites; Crystallography, X-Ray; Glycogen Phosphorylase; Hypoglycemic Agents; Kinetics; Models, Molecular; Muscles; Oleanolic Acid; Pentacyclic Triterpenes; Protein Binding; Protein Conformation; Rabbits; Stereoisomerism; Structure-Activity Relationship; Triterpenes	2008
Purity-activity relationships of natural products: the case of anti-TB active ursolic acid. Journal of natural products, 2008, Volume: 71, Issue:10 Topics: Animals; Antitubercular Agents; Biological Products; Chlorocebus aethiops; Inhibitory Concentration 50; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Triterpenes; Ursolic Acid; Vero Cells	2008
Antiproliferative triterpenes from Melaleuca ericifolia. Journal of natural products, 2008, Volume: 71, Issue:10 Topics: Animals; Drug Screening Assays, Antitumor; Egypt; Melaleuca; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves; Plants, Medicinal; Triterpenes	2008
Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells. Bioorganic & medicinal chemistry letters, 2009, Oct-01, Volume: 19, Issue:19 Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Glucose; Glycogen; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hypoglycemic Agents; Insulin Resistance; Paeonia; Phosphorylation; Terpenes; Triterpenes	2009
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. Journal of medicinal chemistry, 2010, Jan-14, Volume: 53, Issue:1 Topics: 3T3-L1 Cells; Animals; Betulinic Acid; CHO Cells; Cricetinae; Cricetulus; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Pentacyclic Triterpenes; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship; Triterpenes	2010
Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida. Journal of natural products, 2010, May-28, Volume: 73, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Artocarpus; Drug Screening Assays, Antitumor; Flavonoids; HT29 Cells; Humans; Indonesia; Molecular Structure; NF-kappa B; NF-kappa B p50 Subunit; Plant Stems; Stilbenes; Transcription Factor RelA	2010
Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Animals; Enzyme Inhibitors; Glycogen Phosphorylase, Muscle Form; Models, Molecular; Molecular Conformation; Muscle, Skeletal; Pentacyclic Triterpenes; Quantitative Structure-Activity Relationship; Rabbits; Stereoisomerism	2011
Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid. Journal of natural products, 2011, May-27, Volume: 74, Issue:5 Topics: Aldehyde Reductase; Aldo-Keto Reductases; Antineoplastic Agents, Phytogenic; Drug Resistance, Neoplasm; HeLa Cells; HT29 Cells; Humans; Mitomycin; Models, Molecular; Molecular Structure; Mutation; Oleanolic Acid; Pentacyclic Triterpenes	2011
Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo. Journal of natural products, 2012, Apr-27, Volume: 75, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Dose-Response Relationship, Drug; Heme Oxygenase-1; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 1; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Triterpenes	2012
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13. Bioorganic & medicinal chemistry letters, 2012, Jun-15, Volume: 22, Issue:12 Topics: Adenosine Triphosphate; Antiviral Agents; Apigenin; Breast; Cell Line; Cell Proliferation; Colorimetry; DNA; DNA Helicases; Epithelial Cells; Female; Flavonoids; Fluorescence Resonance Energy Transfer; Hepacivirus; Humans; Hydrolysis; Inhibitory Concentration 50; Kinetics; Methyltransferases; RNA Helicases; Severe acute respiratory syndrome-related coronavirus; Species Specificity; Viral Nonstructural Proteins; Viral Proteins	2012
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22 Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship	2012
Development of oleanane-type triterpenes as a new class of HCV entry inhibitors. Journal of medicinal chemistry, 2013, Jun-13, Volume: 56, Issue:11 Topics: Animals; Antiviral Agents; Cell Line, Tumor; Cytotoxins; HEK293 Cells; Hemolytic Agents; Hepacivirus; Humans; Oleanolic Acid; Rabbits; Structure-Activity Relationship; Virus Internalization	2013
Rat intestinal sucrase inhibition of constituents from the roots of Rosa rugosa Thunb. Bioorganic & medicinal chemistry letters, 2014, Feb-15, Volume: 24, Issue:4 Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Intestine, Small; Molecular Conformation; Plant Roots; Rats; Rosa; Structure-Activity Relationship; Sucrase; Triterpenes	2014
Chemical constituents from Eucalyptus citriodora Hook leaves and their glucose transporter 4 translocation activities. Bioorganic & medicinal chemistry letters, 2014, Jul-15, Volume: 24, Issue:14 Topics: Animals; Cell Line; Chalcones; Crystallography, X-Ray; Eucalyptus; Glucose Transporter Type 4; Models, Molecular; Molecular Structure; Plant Leaves; Rats; Xanthenes	2014
Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics. Journal of medicinal chemistry, 2014, Sep-11, Volume: 57, Issue:17 Topics: Amino Acid Sequence; Antiviral Agents; Cell Line; Cell Line, Tumor; Cell Survival; Enfuvirtide; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV-1; Humans; Models, Chemical; Models, Molecular; Molecular Sequence Data; Molecular Structure; Peptide Fragments; Protein Structure, Secondary; Sapogenins; Structure-Activity Relationship	2014
Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates. Bioorganic & medicinal chemistry letters, 2014, Nov-15, Volume: 24, Issue:22 Topics: Araliaceae; Cytotoxins; Drug Evaluation, Preclinical; Eleutherococcus; Esters; Hep G2 Cells; Humans; Plant Extracts; Triazoles; Triterpenes; Zidovudine	2014
Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. European journal of medicinal chemistry, 2015, Sep-18, Volume: 102 Topics: Antiviral Agents; Dose-Response Relationship, Drug; Hepacivirus; Microbial Sensitivity Tests; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship	2015
Discovery of α-mangostin as a novel competitive inhibitor against mutant isocitrate dehydrogenase-1. Bioorganic & medicinal chemistry letters, 2015, Dec-01, Volume: 25, Issue:23 Topics: Binding, Competitive; Drug Discovery; Humans; Isocitrate Dehydrogenase; MCF-7 Cells; Molecular Structure; Mutation; Recombinant Proteins; Structure-Activity Relationship; Xanthones	2015
Targeting cancer cells with oleanolic and ursolic acid derived hydroxamates. Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Oleanolic Acid; Structure-Activity Relationship; Triterpenes; Ursolic Acid	2016
Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera. Bioorganic & medicinal chemistry, 2016, 06-01, Volume: 24, Issue:11 Topics: Antimalarials; Cell Survival; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Malaria; Molecular Structure; Myrtaceae; Parasitic Sensitivity Tests; Phloroglucinol; Plant Bark; Plasmodium falciparum; Structure-Activity Relationship	2016
Urea derivates of ursolic, oleanolic and maslinic acid induce apoptosis and are selective cytotoxic for several human tumor cell lines. European journal of medicinal chemistry, 2016, Aug-25, Volume: 119 Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Mice; NIH 3T3 Cells; Oleanolic Acid; Structure-Activity Relationship; Triterpenes; Ursolic Acid	2016
Triterpene sapogenin-polyarginine conjugates exhibit promising antibacterial activity against Gram-positive strains. Bioorganic & medicinal chemistry, 2016, 07-01, Volume: 24, Issue:13 Topics: Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Molecular Structure; Peptides; Plasma; Sapogenins; Triterpenes	2016
Rhodamine B conjugates of triterpenoic acids are cytotoxic mitocans even at nanomolar concentrations. European journal of medicinal chemistry, 2017, Feb-15, Volume: 127 Topics: Animals; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Mitochondria; NIH 3T3 Cells; Rhodamines; Structure-Activity Relationship; Triterpenes	2017
Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase. European journal of medicinal chemistry, 2017, Apr-21, Volume: 130 Topics: Amides; Anti-HIV Agents; Binding Sites; Caffeic Acids; Coumaric Acids; DNA-Directed DNA Polymerase; Esters; HIV Reverse Transcriptase; Plant Extracts; Ribonuclease H, Human Immunodeficiency Virus; Structure-Activity Relationship; Triterpenes	2017
Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors. European journal of medicinal chemistry, 2017, Oct-20, Volume: 139 Topics: Animals; Cholesterol Ester Transfer Proteins; Dose-Response Relationship, Drug; Drug Discovery; Esters; Guinea Pigs; Humans; Mice; Mice, Transgenic; Molecular Structure; Structure-Activity Relationship; Triterpenes	2017
Pentacyclic triterpenes as α-glucosidase and α-amylase inhibitors: Structure-activity relationships and the synergism with acarbose. Bioorganic & medicinal chemistry letters, 2017, 11-15, Volume: 27, Issue:22 Topics: Acarbose; alpha-Amylases; alpha-Glucosidases; Drug Synergism; Inhibitory Concentration 50; Kinetics; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes	2017
Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes. European journal of medicinal chemistry, 2018, Jan-01, Volume: 143 Topics: Antitubercular Agents; Azepines; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Triterpenes	2018
Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. Bioorganic & medicinal chemistry, 2018, 08-15, Volume: 26, Issue:15 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Conformation; NF-kappa B; Plant Extracts; Plant Leaves; Structure-Activity Relationship; Syzygium; Triterpenes; Ursolic Acid	2018
Sentulic acid isolated from Sandoricum koetjape Merr attenuates lipopolysaccharide and interferon gamma co-stimulated nitric oxide production in murine macrophage RAW264 cells. Bioorganic & medicinal chemistry letters, 2018, 12-01, Volume: 28, Issue:22 Topics: Animals; Cyclooxygenase 2; Down-Regulation; Interferon-gamma; Interleukin-6; Lipopolysaccharides; Macrophages; Meliaceae; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptors; Triterpenes; Tumor Necrosis Factor-alpha	2018
Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors. Journal of natural products, 2018, 10-26, Volume: 81, Issue:10 Topics: Enzyme Inhibitors; HEK293 Cells; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; NF-kappa B; Triterpenes	2018
Design, synthesis and cytotoxicity of BODIPY FL labelled triterpenoids. European journal of medicinal chemistry, 2020, Jan-01, Volume: 185 Topics: Antineoplastic Agents; Boron Compounds; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; MCF-7 Cells; Molecular Structure; Structure-Activity Relationship; Triterpenes	2020
Optimized plant compound with potent anti-biofilm activity across gram-negative species. Bioorganic & medicinal chemistry, 2020, 03-01, Volume: 28, Issue:5 Topics: Amines; Anti-Bacterial Agents; Biofilms; Dose-Response Relationship, Drug; Gram-Negative Bacteria; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship	2020
Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line. Bioorganic & medicinal chemistry letters, 2020, 08-15, Volume: 30, Issue:16 Topics: Antineoplastic Agents, Phytogenic; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Egypt; Humans; Molecular Structure; Myrtaceae; Pancreatic Neoplasms; Structure-Activity Relationship; Terpenes; Tumor Microenvironment	2020
Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. European journal of medicinal chemistry, 2021, Jan-01, Volume: 209 Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Glycyrrhizic Acid; Humans; Interleukin-6; Liver; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Oleanolic Acid; Pentacyclic Triterpenes; Phosphorylation; Sapogenins; Saponins; Tumor Necrosis Factor-alpha	2021
Tumor inhibitory agents from Vauquelinia corymbosa (Rosaceae). Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:9 Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Triterpenes; Ursolic Acid	1976
[Isolation and identification of chemical constituents from Hedyotis chrysotricha (Palib.) Merr]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 1992, Volume: 17, Issue:2 Topics: Anti-Infective Agents; Antineoplastic Agents, Phytogenic; Betulinic Acid; Cyclopentane Monoterpenes; Drugs, Chinese Herbal; Glucosides; Pentacyclic Triterpenes; Pyrans; Triterpenes; Ursolic Acid	1992
Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. Planta medica, 1995, Volume: 61, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Female; Mice; Pentacyclic Triterpenes; Plants, Medicinal; Steroids; Triterpenes; Ursolic Acid	1995
Effect of selected triterpenoids on chronic dermal inflammation. European journal of pharmacology, 1997, Sep-03, Volume: 334, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Dermatitis, Contact; Dexamethasone; Drug Evaluation, Preclinical; Female; Mice; Oleanolic Acid; Pentacyclic Triterpenes; Tetradecanoylphorbol Acetate; Triterpenes; Ursolic Acid	1997
In vitro and in vivo evaluation of betulinic acid as an antimalarial. Phytotherapy research : PTR, 1999, Volume: 13, Issue:2 Topics: Animals; Antimalarials; Betulinic Acid; Disease Models, Animal; Euphorbiaceae; Malaria; Mice; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Plant Roots; Plasmodium berghei; Plasmodium falciparum; Random Allocation; Structure-Activity Relationship; Triterpenes; Ursolic Acid	1999
Cytotoxic triterpenes from stem bark of Physocarpus intermedius. Planta medica, 2000, Volume: 66, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Humans; Magnetic Resonance Spectroscopy; Oleanolic Acid; Pentacyclic Triterpenes; Plant Stems; Rosales; Triterpenes; Tumor Cells, Cultured; Ursolic Acid	2000
Synthesis of combinatorial libraries based on terpenoid scaffolds. Combinatorial chemistry & high throughput screening, 2002, Volume: 5, Issue:3 Topics: Animals; Antimalarials; Betulinic Acid; Combinatorial Chemistry Techniques; Drug Evaluation, Preclinical; Indicators and Reagents; Oxidation-Reduction; Oximes; Pentacyclic Triterpenes; Plasmodium falciparum; Resins, Plant; Terpenes; Triterpenes; Ursolic Acid	2002
Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L. Phytotherapy research : PTR, 2003, Volume: 17, Issue:2 Topics: Animals; Anti-Bacterial Agents; Bacillus subtilis; Betulinic Acid; Dose-Response Relationship, Drug; Escherichia coli; Feeding Behavior; Humans; Insecticides; Larva; Microbial Sensitivity Tests; Moths; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Plant Leaves; Triterpenes; Ursolic Acid; Vitex	2003
New ursolic and betulinic derivatives as potential cytotoxic agents. Journal of enzyme inhibition and medicinal chemistry, 2003, Volume: 18, Issue:2 Topics: Antineoplastic Agents; Betulinic Acid; Cell Survival; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes; Ursolic Acid	2003
Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection. Journal of separation science, 2004, Volume: 27, Issue:12 Topics: Betulinic Acid; Carbon; Chromatography, Liquid; Glycyrrhetinic Acid; Light; Models, Chemical; Models, Molecular; Oleanolic Acid; Pentacyclic Triterpenes; Scattering, Radiation; Time Factors; Triterpenes; Ultraviolet Rays; Ursolic Acid	2004
Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Erythroblasts; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Triterpenes; Ursolic Acid; Viscum	2005
Antibacterial constituents from fruit bodies of ascomyce Bulgaria inquinans. Archives of pharmacal research, 2005, Volume: 28, Issue:8 Topics: Anti-Bacterial Agents; Ascomycota; Betulinic Acid; China; Magnetic Resonance Spectroscopy; Pentacyclic Triterpenes; Phytosterols; Spectrometry, Mass, Electrospray Ionization; Triterpenes; Ursolic Acid	2005
Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:2 Topics: Animals; Betulinic Acid; Cell Line; Enzyme Inhibitors; Humans; Lycopus; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Triterpenes; Ursolic Acid	2006
Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa. Journal of ethnopharmacology, 2007, Sep-05, Volume: 113, Issue:2 Topics: 1-Butanol; Acetates; Animals; Antidiarrheals; Bacterial Toxins; Betulinic Acid; Diarrhea; Dose-Response Relationship, Drug; Enterotoxins; Enzyme-Linked Immunosorbent Assay; Escherichia coli Proteins; Female; Fruit; Immunoglobulin M; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Protein Binding; Protein Subunits; Rosaceae; Triterpenes; Ursolic Acid	2007
Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids. Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:2 Topics: Acetylation; Antitubercular Agents; Betulinic Acid; Cinnamates; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methylation; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oleanolic Acid; Pentacyclic Triterpenes; Spectrometry, Mass, Fast Atom Bombardment; Spectroscopy, Fourier Transform Infrared; Triterpenes; Ursolic Acid	2008
Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid. The Journal of organic chemistry, 2008, Sep-19, Volume: 73, Issue:18 Topics: Betulinic Acid; Molecular Conformation; Oleanolic Acid; Pentacyclic Triterpenes; Stereoisomerism; Triterpenes; Ursolic Acid	2008
Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes. Journal of ethnopharmacology, 2008, Nov-20, Volume: 120, Issue:2 Topics: Anti-Bacterial Agents; Betulinic Acid; Cell Line; Cell Survival; Drug Resistance, Bacterial; Eukaryotic Cells; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Microbial Sensitivity Tests; Oleanolic Acid; Pentacyclic Triterpenes; Toxicity Tests; Triterpenes; Ursolic Acid	2008
Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts. Molecules (Basel, Switzerland), 2009, Jun-04, Volume: 14, Issue:6 Topics: Betulinic Acid; Chromatography, Gas; Chromatography, High Pressure Liquid; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Triterpenes; Ursolic Acid	2009
Chemical composition of the stem bark and leaves of Ficus pandurata Hance. Natural product research, 2009, Volume: 23, Issue:13 Topics: Betulinic Acid; Ficus; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Bark; Plant Leaves; Sitosterols; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stigmasterol; Triterpenes; Ursolic Acid	2009
Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). Phytotherapy research : PTR, 2011, Volume: 25, Issue:2 Topics: Betulinic Acid; Cell Line; Cell Survival; Humans; Immunologic Factors; Interleukin-6; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Rosa; Triterpenes; Ursolic Acid	2011
[Studies on the triterpenoids of Vitex trifolia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2010, Volume: 33, Issue:6 Topics: Betulinic Acid; Ethanol; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Triterpenes; Ursolic Acid; Vitex	2010
Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Betulinic Acid; Chromatography, High Pressure Liquid; Fluorescent Dyes; Food Analysis; Fruit; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid	2011
CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis. Plant & cell physiology, 2011, Volume: 52, Issue:12 Topics: Amino Acid Sequence; Betulinic Acid; Biosynthetic Pathways; Cloning, Molecular; Cytochrome P-450 Enzyme System; Intramolecular Transferases; Medicago truncatula; Multienzyme Complexes; Oleanolic Acid; Pentacyclic Triterpenes; Phylogeny; Saccharomyces cerevisiae; Triterpenes; Ursolic Acid; Vitis	2011
Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell cultures. Phytotherapy research : PTR, 2012, Volume: 26, Issue:8 Topics: Acids; Autoantigens; B-Lymphocytes; Betulinic Acid; CD4-Positive T-Lymphocytes; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Immunologic; Flow Cytometry; Humans; Immunologic Factors; Inhibitory Concentration 50; Interleukin-10; Lipopolysaccharides; Oleanolic Acid; Pentacyclic Triterpenes; Plant Preparations; Rosa; Thyroglobulin; Triterpenes; Tumor Necrosis Factor-alpha; Ursolic Acid	2012
[Study on the chemical constituents of Leptopus chineseis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2011, Volume: 34, Issue:8 Topics: Betulinic Acid; Euphorbiaceae; Magnetic Resonance Spectroscopy; Molecular Structure; Pentacyclic Triterpenes; Plants, Medicinal; Triterpenes; Ursolic Acid	2011
Triterpenes from Callicarpa integerrima Champ. Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:1 Topics: Betulinic Acid; Callicarpa; Molecular Conformation; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Plant Stems; Plants, Medicinal; Saponins; Triterpenes; Ursolic Acid	2012
[Chemical constituents of Dolomiaea souliei]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:9 Topics: 4-Butyrolactone; Asteraceae; Betulinic Acid; Emodin; Lactones; Pentacyclic Triterpenes; Sesquiterpenes; Triterpenes; Ursolic Acid	2012
Bioactive oleanane, lupane and ursane triterpene acid derivatives. Molecules (Basel, Switzerland), 2012, Oct-17, Volume: 17, Issue:10 Topics: Animals; Artemia; Betulinic Acid; Esters; Free Radical Scavengers; Lamiaceae; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Triterpenes; Ursolic Acid	2012
Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues. Molecules (Basel, Switzerland), 2012, Oct-12, Volume: 17, Issue:10 Topics: Antimalarials; Betulinic Acid; Erythrocytes; HEK293 Cells; Humans; Inhibitory Concentration 50; Parasitic Sensitivity Tests; Pentacyclic Triterpenes; Plasmodium falciparum; Triterpenes; Ursolic Acid	2012
A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. Food chemistry, 2013, Jan-15, Volume: 136, Issue:2 Topics: Betulinic Acid; Dietary Supplements; Gas Chromatography-Mass Spectrometry; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Plants; Triterpenes; Ursolic Acid	2013
Two series of new semisynthetic triterpene derivatives: differences in anti-malarial activity, cytotoxicity and mechanism of action. Malaria journal, 2013, Mar-09, Volume: 12 Topics: Antimalarials; Betulinic Acid; Cell Line; Cell Survival; Epithelial Cells; Humans; Pentacyclic Triterpenes; Plasmodium falciparum; Triterpenes; Ursolic Acid	2013
Synthesis of isosteric triterpenoid derivatives and antifungal activity. Chemical biology & drug design, 2014, Volume: 83, Issue:3 Topics: Antifungal Agents; Arthrodermataceae; Betulinic Acid; Microbial Sensitivity Tests; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid; Yeasts	2014
Anti-Trichomonas vaginalis activity from triterpenoid derivatives. Parasitology research, 2014, Volume: 113, Issue:8 Topics: Antitrichomonal Agents; Betulinic Acid; Drug Resistance; Erythrocytes; Female; HeLa Cells; Hemolysis; Humans; Male; Metronidazole; Microbial Sensitivity Tests; Pentacyclic Triterpenes; Piperazine; Piperazines; Trichomonas vaginalis; Triterpenes; Ursolic Acid	2014
Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. Biochemical and biophysical research communications, 2014, Aug-22, Volume: 451, Issue:2 Topics: Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Estrogen Receptor alpha; Estrogen Receptor Modulators; Estrogens; Female; Humans; Male; MCF-7 Cells; Neoplasm Proteins; Pentacyclic Triterpenes; Phytotherapy; Plants, Medicinal; Promoter Regions, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms; Prunella; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Triterpenes; Ursolic Acid	2014
RP-HPLC simultaneous estimation of betulinic acid and ursolic acid in Carissa spinarum. Natural product research, 2014, Volume: 28, Issue:21 Topics: Apocynaceae; Betulinic Acid; Chromatography, High Pressure Liquid; Molecular Structure; Pentacyclic Triterpenes; Plant Roots; Plants, Medicinal; Triterpenes; Ursolic Acid	2014
Chemical constituents of gold-red apple and their α-glucosidase inhibitory activities. Journal of food science, 2014, Volume: 79, Issue:10 Topics: alpha-Glucosidases; alpha-Linolenic Acid; Betulinic Acid; Fruit; Glycoside Hydrolase Inhibitors; Magnetic Resonance Spectroscopy; Malus; Oleanolic Acid; Pentacyclic Triterpenes; Spectrometry, Mass, Electrospray Ionization; Triterpenes; Ursolic Acid	2014
Incorporation of pentacyclic triterpenes into mitochondrial membrane--studies on the interactions in model 2D lipid systems. The journal of physical chemistry. B, 2014, Nov-13, Volume: 118, Issue:45 Topics: Betulinic Acid; Cardiolipins; Hydrogen Bonding; Mitochondrial Membranes; Models, Molecular; Pentacyclic Triterpenes; Phosphatidylcholines; Phosphatidylethanolamines; Thermodynamics; Triterpenes; Ursolic Acid	2014
Anti-tumor activities of triterpenes from Syzygium kusukusense. Natural product communications, 2014, Volume: 9, Issue:11 Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Betulinic Acid; Cell Line, Tumor; Cell Survival; Humans; Pentacyclic Triterpenes; Plant Stems; Syzygium; Triterpenes; Ursolic Acid	2014
Simultaneous determination of six triterpenic acids in some Chinese medicinal herbs using ultrasound-assisted dispersive liquid-liquid microextraction and high-performance liquid chromatography with fluorescence detection. Journal of pharmaceutical and biomedical analysis, 2015, Mar-25, Volume: 107 Topics: Betulinic Acid; Chromatography, High Pressure Liquid; Fluorescence; Limit of Detection; Liquid Phase Microextraction; Medicine, Chinese Traditional; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Solvents; Triterpenes; Ultrasonics; Ursolic Acid	2015
Quantitative determination of three pentacyclic triterpenes from five Swertia L. species endemic to Western Ghats, India, using RP-HPLC analysis. Natural product research, 2015, Volume: 29, Issue:19 Topics: Betulinic Acid; Chromatography, High Pressure Liquid; India; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plants, Medicinal; Species Specificity; Swertia; Triterpenes; Ursolic Acid	2015
Sesqui- and triterpenoids from the liverwort Lepidozia chordulifera inhibitors of bacterial biofilm and elastase activity of human pathogenic bacteria. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2015, Jan-15, Volume: 22, Issue:1 Topics: Betulinic Acid; Biofilms; Enzyme Inhibitors; Hepatophyta; Molecular Structure; Pancreatic Elastase; Pentacyclic Triterpenes; Pseudomonas aeruginosa; Quorum Sensing; Sesquiterpenes; Staphylococcus aureus; Structure-Activity Relationship; Terpenes; Triterpenes; Ursolic Acid	2015
α-Glucosidase Inhibitors from Vauquelinia corymbosa. Molecules (Basel, Switzerland), 2015, Aug-21, Volume: 20, Issue:8 Topics: Betulinic Acid; Glycoside Hydrolase Inhibitors; Inhibitory Concentration 50; Molecular Docking Simulation; Pentacyclic Triterpenes; Plant Extracts; Rosaceae; Triterpenes; Ursolic Acid	2015
[Study on Chemical Composition of Phyllanthus emblica]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015, Volume: 38, Issue:2 Topics: Betulinic Acid; Gallic Acid; Oleanolic Acid; Pentacyclic Triterpenes; Phyllanthus emblica; Phytochemicals; Plants, Medicinal; Quercetin; Rutin; Triterpenes; Ursolic Acid	2015
Determination of betulinic acid, oleanolic acid and ursolic acid from Achyranthes aspera L. using RP-UFLC-DAD analysis and evaluation of various parameters for their optimum yield. Indian journal of experimental biology, 2016, Volume: 54, Issue:3 Topics: Achyranthes; Betulinic Acid; Chromatography, Reverse-Phase; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid	2016
Antimycobacterial triterpenes from the Canadian medicinal plant Sarracenia purpurea. Journal of ethnopharmacology, 2016, Jul-21, Volume: 188 Topics: Anti-Bacterial Agents; Betulinic Acid; Carbon-13 Magnetic Resonance Spectroscopy; Mass Spectrometry; Methanol; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pentacyclic Triterpenes; Phytotherapy; Plant Extracts; Plants, Medicinal; Proton Magnetic Resonance Spectroscopy; Sarraceniaceae; Solvents; Triterpenes; Ursolic Acid	2016
[Chemical Constituents from Camellia oleifera Stem]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2015, Volume: 38, Issue:10 Topics: Betulinic Acid; Camellia; Drugs, Chinese Herbal; Flavonoids; Furans; Lignans; Oleanolic Acid; Pentacyclic Triterpenes; Phytochemicals; Plant Stems; Plants, Medicinal; Triterpenes; Ursolic Acid	2015
Larvicidal activity of natural and modified triterpenoids against Aedes aegypti (Diptera: Culicidae). Pest management science, 2016, Volume: 72, Issue:10 Topics: Aedes; Animals; Betulinic Acid; Dengue; Diflubenzuron; Insect Vectors; Insecticides; Larva; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid	2016
Synthesis, structural studies, and cytotoxic evaluation of novel ursolic acid hybrids with capabilities to arrest breast cancer cells in mitosis. Journal of Asian natural products research, 2017, Volume: 19, Issue:3 Topics: Betulinic Acid; Cell Cycle; Click Chemistry; Drug Screening Assays, Antitumor; Female; Humans; Mitosis; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pentacyclic Triterpenes; Triazoles; Triterpenes; Ursolic Acid	2017
Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells. Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:6 Topics: Apoptosis; Autophagy; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Female; G1 Phase Cell Cycle Checkpoints; Glycolysis; Humans; Models, Biological; Nitrosation; Oxidative Stress; Pentacyclic Triterpenes; Phenotype; Signal Transduction; Triterpenes; Ursolic Acid	2017
Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation. Redox biology, 2017, Volume: 12 Topics: Antineoplastic Agents, Phytogenic; Betulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Isothiocyanates; MCF-7 Cells; Pentacyclic Triterpenes; Protein Carbonylation; Sulfoxides; Superoxides; Triterpenes; Ursolic Acid	2017
Triterpenoids Isolated from Ziziphus jujuba Enhance Glucose Uptake Activity in Skeletal Muscle Cells. Journal of nutritional science and vitaminology, 2017, Volume: 63, Issue:3 Topics: Animals; Betulinic Acid; Carbohydrate Metabolism; Cell Survival; Cells, Cultured; Glucose; Muscle Fibers, Skeletal; Pentacyclic Triterpenes; Plant Extracts; Rats; Triterpenes; Ursolic Acid; Ziziphus	2017
Influence of oxidative stress on the antibacterial activity of betulin, betulinic acid and ursolic acid. Microbial pathogenesis, 2017, Volume: 111 Topics: Anti-Bacterial Agents; Betulinic Acid; DNA Fragmentation; Escherichia coli; Glutathione; Malondialdehyde; Microbial Sensitivity Tests; Oxidative Stress; Pentacyclic Triterpenes; Pseudomonas aeruginosa; Reactive Oxygen Species; Staphylococcus aureus; Triterpenes; Ursolic Acid	2017
Antimicrobial Mechanism of Oleanolic and Ursolic Acids on Streptococcus mutans UA159. Current microbiology, 2018, Volume: 75, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Proteins; Betulinic Acid; Gene Expression Regulation, Bacterial; Oleanolic Acid; Pentacyclic Triterpenes; Streptococcus mutans; Triterpenes; Ursolic Acid	2018
Anti-Proliferative Activity of Triterpenoids and Sterols Isolated from Alstonia scholaris against Non-Small-Cell Lung Carcinoma Cells. Molecules (Basel, Switzerland), 2017, Dec-01, Volume: 22, Issue:12 Topics: A549 Cells; Alstonia; Antineoplastic Agents; Betulinic Acid; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Humans; Lung Neoplasms; Pentacyclic Triterpenes; Phytosterols; Plant Extracts; Plant Leaves; Sterols; Tetrazolium Salts; Thiazoles; Triterpenes; Ursolic Acid	2017
Betulinic, oleanolic and ursolic acids inhibit the enzymatic and biological effects induced by a P-I snake venom metalloproteinase. Chemico-biological interactions, 2018, Jan-05, Volume: 279 Topics: Animals; Betulinic Acid; Bothrops; Crotalid Venoms; Edema; Hemorrhage; Metalloproteases; Mice; Molecular Structure; Muscular Diseases; Oleanolic Acid; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid	2018
Study of isomeric pentacyclic triterpene acids in traditional Chinese medicine of Forsythiae Fructus and their binding constants with β-cyclodextrin by capillary electrophoresis. Electrophoresis, 2018, Volume: 39, Issue:7 Topics: beta-Cyclodextrins; Betulinic Acid; Drugs, Chinese Herbal; Electrophoresis, Capillary; Forsythia; Fruit; Isomerism; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Structure-Activity Relationship; Thermodynamics; Triterpenes; Ursolic Acid	2018
[Chemical Constituents from Rubus stans]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2016, Volume: 39, Issue:5 Topics: Betulinic Acid; Kaempferols; Pentacyclic Triterpenes; Rubus; Sitosterols; Triterpenes; Ursolic Acid	2016
Ethylenediamine Derived Carboxamides of Betulinic and Ursolic Acid as Potential Cytotoxic Agents. Molecules (Basel, Switzerland), 2018, Oct-08, Volume: 23, Issue:10 Topics: Betulinic Acid; Cell Proliferation; Cytotoxins; Drug Screening Assays, Antitumor; Ethylenediamines; HT29 Cells; Humans; Molecular Structure; Pentacyclic Triterpenes; Structure-Activity Relationship; Triterpenes; Ursolic Acid	2018
Effect of an anxiolytic botanical containing Souroubea sympetala and Platanus occidentalis on in-vitro diazepam human cytochrome P450-mediated metabolism. The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:3 Topics: Anti-Anxiety Agents; Betulinic Acid; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Diazepam; Humans; Microsomes, Liver; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; Triterpenes; Ursolic Acid	2019
Quantification of three triterpenic acids in dried rosemary using HPLC-fluorescence detection and 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride derivatization. Luminescence : the journal of biological and chemical luminescence, 2019, Volume: 34, Issue:1 Topics: Benzoates; Betulinic Acid; Calibration; Chromatography, High Pressure Liquid; Fluorescence; Food Analysis; Imidazoles; Limit of Detection; Oleanolic Acid; Pentacyclic Triterpenes; Reproducibility of Results; Rosmarinus; Temperature; Triterpenes; Ursolic Acid	2019
Triterpene Derivatives as Relevant Scaffold for New Antibiofilm Drugs. Biomolecules, 2019, Feb-11, Volume: 9, Issue:2 Topics: Animals; Anti-Bacterial Agents; Betulinic Acid; Biofilms; Chlorocebus aethiops; Dose-Response Relationship, Drug; Enterococcus faecalis; Microbial Sensitivity Tests; Molecular Conformation; Pentacyclic Triterpenes; Staphylococcus aureus; Staphylococcus epidermidis; Structure-Activity Relationship; Triterpenes; Ursolic Acid; Vero Cells	2019
A new pentacyclic triterpenoid from the leaves of Natural product research, 2020, Volume: 34, Issue:23 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Betulinic Acid; Drug Evaluation, Preclinical; Lipopolysaccharides; Mice; Molecular Structure; Nitric Oxide; Oleanolic Acid; Pentacyclic Triterpenes; Plant Extracts; Plant Leaves; RAW 264.7 Cells; Rhododendron; Triterpenes; Ursolic Acid	2020
Antimicrobial properties of amine- and guanidine-functionalized derivatives of betulinic, ursolic and oleanolic acids: Synthesis and structure/activity evaluation. Steroids, 2020, Volume: 154 Topics: Acinetobacter baumannii; Anti-Bacterial Agents; Antifungal Agents; Betulinic Acid; Candida albicans; Cell Survival; Cryptococcus neoformans; Dose-Response Relationship, Drug; Escherichia coli; HEK293 Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Pseudomonas aeruginosa; Structure-Activity Relationship; Triterpenes; Ursolic Acid	2020
A Highly Active Triterpene Derivative Capable \|of Biofilm Damage to Control Biomolecules, 2019, 12-05, Volume: 9, Issue:12 Topics: Betulinic Acid; Biofilms; Cell Line; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Fungal; Humans; Microbial Sensitivity Tests; Molecular Structure; Pentacyclic Triterpenes; Triterpenes; Ursolic Acid	2019
Triple Negative Breast Cancer and Breast Epithelial Cells Differentially Reprogram Glucose and Lipid Metabolism upon Treatment with Triterpenic Acids. Biomolecules, 2020, 08-08, Volume: 10, Issue:8 Topics: Betulinic Acid; Breast; Cell Cycle; Cell Line, Tumor; Cell Survival; Citric Acid Cycle; Epithelial Cells; Female; Glucose; Glycolysis; Hexosamines; Humans; Lipid Metabolism; Magnetic Resonance Spectroscopy; Metabolome; Metabolomics; Pentacyclic Triterpenes; Triple Negative Breast Neoplasms; Triterpenes; Ursolic Acid	2020
Ursolic and betulinic semisynthetic derivatives show activity against CQ-resistant Plasmodium falciparum isolated from Amazonia. Chemical biology & drug design, 2021, Volume: 97, Issue:5 Topics: Antimalarials; Betulinic Acid; Binding Sites; Brazil; Chloroquine; DNA Topoisomerases, Type II; Drug Resistance; Life Cycle Stages; Molecular Docking Simulation; Pentacyclic Triterpenes; Plasmodium falciparum; Protozoan Proteins; Structure-Activity Relationship; Triterpenes; Ursolic Acid	2021
Olive-Derived Triterpenes Suppress SARS COV-2 Main Protease: A Promising Scaffold for Future Therapeutics. Molecules (Basel, Switzerland), 2021, May-01, Volume: 26, Issue:9 Topics: Antiviral Agents; Betulinic Acid; Coronavirus 3C Proteases; COVID-19; COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Olea; Pentacyclic Triterpenes; Protease Inhibitors; SARS-CoV-2; Triterpenes; Ursolic Acid	2021