ursodoxicoltaurine has been researched along with diminazene-aceturate* in 1 studies
1 other study(ies) available for ursodoxicoltaurine and diminazene-aceturate
| Article | Year |
|---|---|
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats.
Persistent hyperglycemia in type 1 diabetes triggers numerous signaling pathways, which may prove deleterious to the endothelium. As hyperglycemia damages the endothelial layer via multiple signaling pathways, including enhanced oxidative stress, downregulation of angiotensin-converting enzyme 2 signaling, and exacerbation of endoplasmic reticulum (ER) stress, it becomes difficult to prevent injury using monotherapy. Thus, the present study was conceived to evaluate the combined effect of ER stress inhibition along with angiotensin-converting enzyme 2 activation, two major contributors to hyperglycemia-induced endothelial dysfunction, in preventing endothelial dysfunction associated with type 1 diabetes. Streptozotocin-induced diabetic animals were treated with either diminazene aceturate (5 mg·kg Topics: Angiotensin-Converting Enzyme 2; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diminazene; Drug Therapy, Combination; Endoplasmic Reticulum Stress; Endothelium, Vascular; Male; Oxidative Stress; Rats, Wistar; Streptozocin; Taurochenodeoxycholic Acid | 2022 |