Compounds > uridine
Page last updated: 2024-08-17

uridine and tsao-t

uridine has been researched along with tsao-t in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's23 (54.76)18.2507
2000's17 (40.48)29.6817
2010's2 (4.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Balzarini, J; Camarasa, MJ; De Clercq, E; Pérez-Pérez, MJ; San-Félix, A1
Balzarini, J; Camarasa, MJ; De Clercq, E; Pérez-Pérez, MJ; San-Félix, A; Velázquez, S2
Balzarini, J; Camarasa, MJ; De Clercq, E; Emini, EA; Karlsson, A; Sardana, VV1
Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Kleim, JP; Riess, G1
Anné, J; Balzarini, J; Camarasa, MJ; De Clercq, E; Desmyter, J; Jonckheere, H; Taymans, JM; Velázquez, S1
Alvarez, R; Aquaro, S; Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Perno, CF; San-Félix, A; Velázquez, S1
Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Jimeno, ML; San-Félix, A; Velázquez, S1
Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Perez-Perez, MJ; San-Felix, A; Velazquez, S1
Bäckbro, K; Balzarini, J; Karlsson, A; Oberg, B; Pérez-Pérez, MJ; San-Félix, A; Unge, T; Vandamme, AM; Vrang, L; Zhang, H1
Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Pérez-Pérez, MJ; Tarpley, WG1
Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Pérez-Pérez, MJ1
Balzarini, J2
Balzarini, J; Bohman, C; Camarasa, MJ; De Clercq, E; Naesens, L; Pérez-Pérez, MJ; San-Félix, A1
Balzarini, J; Camarasa, MJ; De Clercq, E; Ingate, S; Pérez-Pérez, MJ1
Balzarini, J; Camarasa, MJ; De Clercq, E; Ingate, S1
Garg, R; Gupta, SP1
Alvarez, R; Balzarini, J; Camarasa, MJ; Chamorro, C; De Clercq, E; Gago, F; Jimeno, ML; Martín-Domenech, A; Pérez, C; Pérez-Pérez, MJ; San-Félix, A; Velázquez, S1
Alvarez, R; Balzarini, J; Camarasa, MJ; De Clercq, E; Gago, F; Pérez, C; Velázquez, S1
Balzarini, J; Camarasa, MJ; Chamorro, C; de Clercq, E; Pérez-Pérez, MJ; San Félix, A1
Alvarez, R; Balzarini, J; Camarasa, MJ; Gago, F; Jimeno, ML; Pérez-Pérez, MJ1
Balzarini, J; Camarasa, MJ; Chamorro, C; De Clercq, E; Jimeno, ML; Tuñón, V; Velázquez, S1
Balzarini, J; Camarasa, MJ; Chamorro, C; De Clercq, E; San-Félix, A1
Aertsen, A; Balzarini, J; Camarasa, MJ; De Clercq, E; Pelemans, H; Pérez-Pérez, MJ; San-Félix, A; Van Laethem, K; Vandamme, AM; Velázquez, S1
Anderson, JN; Balzarini, J; Camarasa, MJ; De Clercq, E; Karlsson, A; Pérez-Pérez, MJ; Perno, CF; San-Félix, A; Velázquez, S1
Balzarini, J; Camarasa, MJ; Chamorro, C; De Clercq, E; Gago, F; Pérez-Pérez, MJ; Rodríguez-Barrios, F; San-Félix, A1
Campiani, G; Catalanotti, B; Fattorusso, C; Maga, G; Morelli, E; Nacci, V; Novellino, E; Ramunno, A1
Balzarini, J; Camarasa, MJ; De Clercq, E; Gago, F; Lobatón, E; Pérez-Pérez, MJ; Rodríguez-Barrios, F; Velázquez, S1
Balzarini, J; Camarasa, MJ; De Clercq, E; Koontz, DL; Lobatón, E; Mellors, JW; Velázquez, S1
Bonache, MC; Camarasa, MJ; Chamorro, C; Cordeiro, A; Jimeno, ML; San-Félix, A1
Félix, AS1
Balzarini, J; De Clercq, E; Len, C; Marco-Contelles, JL; Nguyen Van Nhien, A; Pannecouque, C; Postel, D; Tomassi, C1
Camarasa, MJ; Pérez-Pérez, MJ; San-Félix, A; Velázquez, S1
Balzarini, J; Barrios, FR; Bonache, MC; Camarasa, MJ; Chamorro, C; De Clercq, E; Gago, F; San-Félix, A; Velázquez, S1
Bonache, MC; Camarasa, MJ; De Castro, S; Pérez-Pérez, MJ; San-Félix, A; Velázquez, S1
Balzarini, J; Camarasa, MJ; Hamamouch, N; San Félix, A; Sluis-Cremer, N; Velazquez, S1
Balzarini, J; Bonache, MC; Camarasa, MJ; De Meester, I; García-Aparicio, C; San-Félix, A; Velazquez, S1
Balzarini, J; Camarasa, MJ; Diez-Torrubia, A; García-Aparicio, C; Lambeir, AM; Velázquez, S1
Balzarini, J; Bonache, MC; Camarasa, MJ; Pérez-Pérez, MJ; Quesada, E; San-Félix, A; Sheen, CW; Sluis-Cremer, N1
Arnold, E; Balzarini, J; Bauman, JD; Camarasa, MJ; Clark, AD; Das, K; Dharia, C; Rim, AS1
Balzarini, J; Castelain, S; Duverlie, G; Fournier, C; Josse, S; Marco-Contelles, J; Moura, M; Nguyen Van Nhien, A; Postel, D; Soriano, E1

Reviews

4 review(s) available for uridine and tsao-t

ArticleYear
Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.
    Pharmacy world & science : PWS, 1994, Apr-15, Volume: 16, Issue:2

    Topics: Animals; Antiviral Agents; Dideoxyadenosine; Dideoxynucleosides; Humans; Lamivudine; Purines; Pyrimidines; Retroviridae; Spiro Compounds; Stavudine; Thymidine; Uridine; Zalcitabine; Zidovudine

1994
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives.
    Current pharmaceutical design, 2002, Volume: 8, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Alkynes; Anti-HIV Agents; Benzodiazepinones; Benzoxazines; Cyclopropanes; Delavirdine; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Viral; Drug Therapy, Combination; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Structure; Nevirapine; Nucleosides; Oxazines; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Uridine

2002
TSAO derivatives the first non-peptide inhibitors of HIV-1 RT dimerization.
    Antiviral chemistry & chemotherapy, 2005, Volume: 16, Issue:3

    Topics: Anti-HIV Agents; Dimerization; HIV Reverse Transcriptase; Humans; Organosilicon Compounds; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Uridine

2005
TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.
    Current pharmaceutical design, 2006, Volume: 12, Issue:15

    Topics: Binding Sites; Dimerization; Enzyme Stability; HIV Reverse Transcriptase; Humans; Models, Molecular; Molecular Structure; Reverse Transcriptase Inhibitors; Spiro Compounds; Technology, Pharmaceutical; Thymidine; Uridine

2006

Other Studies

38 other study(ies) available for uridine and tsao-t

ArticleYear
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro -5''- (4''-amino-1'',2''-oxathiole 2'',2''-dioxide) pyrimidine and pyrimidine-modified nucleosides.
    Journal of medicinal chemistry, 1992, Aug-07, Volume: 35, Issue:16

    Topics: Antiviral Agents; Cells, Cultured; HIV-1; Humans; Nucleosides; Pyrimidines; Spiro Compounds; Structure-Activity Relationship; T-Lymphocytes; Thymidine; Uridine

1992
Novel series of TSAO-T derivatives. Synthesis and anti-HIV-1 activity of 4-, 5-, and 6-substituted pyrimidine analogues.
    Journal of medicinal chemistry, 1994, Feb-18, Volume: 37, Issue:4

    Topics: Antiviral Agents; Cells, Cultured; HIV Reverse Transcriptase; HIV-1; HIV-2; Pyrimidines; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

1994
Human immunodeficiency virus 1 (HIV-1)-specific reverse transcriptase (RT) inhibitors may suppress the replication of specific drug-resistant (E138K)RT HIV-1 mutants or select for highly resistant (Y181C-->C181I)RT HIV-1 mutants.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Jul-05, Volume: 91, Issue:14

    Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Benzodiazepines; Cell Line; Codon; DNA Primers; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Kinetics; Molecular Sequence Data; Nevirapine; Point Mutation; Polymerase Chain Reaction; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine; Virus Replication

1994
Sensitivity of (138 Glu-->Lys) mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to HIV-1-specific RT inhibitors.
    Biochemical and biophysical research communications, 1994, Jun-30, Volume: 201, Issue:3

    Topics: Antiviral Agents; Drug Resistance, Microbial; Glutamates; HIV Reverse Transcriptase; HIV-1; Humans; Mutagenesis, Site-Directed; Pyridones; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

1994
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.
    The Journal of biological chemistry, 1994, Oct-14, Volume: 269, Issue:41

    Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Binding Sites; Deoxyguanine Nucleotides; Dideoxynucleotides; Drug Resistance; Escherichia coli; HIV Reverse Transcriptase; Imidazoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Spiro Compounds; Thymidine; Uridine

1994
1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity.
    Journal of medicinal chemistry, 1994, Nov-25, Volume: 37, Issue:24

    Topics: Antiviral Agents; Base Sequence; Cells, Cultured; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Triazoles; Uridine

1994
Synthesis and anti-HIV activity of [AZT]-[TSAO-T] and [AZT]-[HEPT] dimers as potential multifunctional inhibitors of HIV-1 reverse transcriptase.
    Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10

    Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Polymers; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine; Uridine; Zidovudine

1995
Human immunodeficiency virus type 1-specific [2',5'-bis-O-(tert- butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"- oxathiole-2",2"-dioxide)-purine analogues show a resistance spectrum that is different from that of the human immunodef
    Molecular pharmacology, 1993, Volume: 43, Issue:1

    Topics: Amino Acid Sequence; Antiviral Agents; Base Sequence; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Humans; Hypoxanthines; Molecular Sequence Data; Mutation; RNA-Directed DNA Polymerase; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

1993
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro- 5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-pentofurano syl (TSAO) nucleoside analogues r
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Aug-01, Volume: 90, Issue:15

    Topics: Antiviral Agents; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

1993
Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy.
    Journal of virology, 1993, Volume: 67, Issue:9

    Topics: Amino Acid Sequence; Antiviral Agents; Benzodiazepines; Cell Line; Dideoxynucleosides; Drug Interactions; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Mutagenesis; Nevirapine; Piperazines; Pyridines; Pyridones; RNA-Directed DNA Polymerase; Spiro Compounds; Thymidine; Uridine

1993
Knocking-out concentrations of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus.
    Virology, 1993, Volume: 196, Issue:2

    Topics: Antiviral Agents; Base Sequence; Benzodiazepines; Cells, Cultured; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Microbial Sensitivity Tests; Molecular Sequence Data; Nevirapine; Piperazines; Pyridines; Pyridones; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis; Spiro Compounds; Thymidine; Thymine; Uridine; Virus Replication

1993
Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N- methyl-thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dio xide).
    Biochemical pharmacology, 1993, Jul-06, Volume: 46, Issue:1

    Topics: Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; Cell Line; Half-Life; HIV-1; Humans; Metabolic Clearance Rate; Mice; Models, Chemical; Spiro Compounds; Thymidine; Thymidine Kinase; Thymidine Phosphorylase; Tissue Distribution; Tritium; Uridine

1993
TSAO analogues. 3. Synthesis and anti-HIV-1 activity of 2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl 3'-spiro-5''-(4''-amino-1'',2''-oxathiole 2'',2''-dioxide) purine and purine-modified nucleosides.
    Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cells, Cultured; HIV-1; Humans; Magnetic Resonance Spectroscopy; Purine Nucleosides; Purines; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

1993
Synthesis and anti-HIV-1 activity of novel TSAO-T derivatives modified at the 2'- and 5'-positions of the sugar moiety.
    Antiviral research, 1995, Volume: 27, Issue:3

    Topics: Antiviral Agents; Carbohydrates; Cell Line; HIV-1; HIV-2; Humans; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine; Virus Replication

1995
Novel concepts in the treatment of human immunodeficiency virus type 1 (HIV-1) infections by HIV-1-specific reverse transcriptase inhibitors.
    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1995, Volume: 57, Issue:6

    Topics: Animals; Antiviral Agents; Drug Resistance; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mice; Models, Molecular; Point Mutation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spiro Compounds; Thymidine; Uridine

1995
Novel L-lyxo and 5'-deoxy-5'-modified TSAO-T analogs: synthesis and anti-HIV-1 activity.
    Antiviral research, 1996, Volume: 32, Issue:3

    Topics: Anti-HIV Agents; Cell Line, Transformed; HIV-1; HIV-2; Humans; Molecular Structure; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Uridine

1996
Quantitative structure-activity relationship studies on some viral reverse transcriptase inhibitors acting as anti-HIV-1 agents.
    Journal of enzyme inhibition, 1997, Volume: 11, Issue:3

    Topics: Anti-HIV Agents; Chemical Phenomena; Chemistry, Physical; HIV Reverse Transcriptase; Humans; Models, Chemical; Molecular Structure; Pyrimidines; Regression Analysis; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

1997
Abasic analogues of TSAO-T as the first sugar derivatives that specifically inhibit HIV-1 reverse transcriptase.
    Journal of medicinal chemistry, 1998, Nov-05, Volume: 41, Issue:23

    Topics: Animals; Anti-HIV Agents; Binding Sites; Carbohydrate Metabolism; Carbohydrates; Cell Line; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mice; Models, Molecular; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Urea; Uridine; Virus Replication

1998
Regiospecific synthesis and anti-human immunodeficiency virus activity of novel 5-substituted N-alkylcarbamoyl and N,N-dialkylcarbamoyl 1,2,3-triazole-TSAO analogues.
    Antiviral chemistry & chemotherapy, 1998, Volume: 9, Issue:6

    Topics: Anti-HIV Agents; Cell Line; Drug Evaluation, Preclinical; HIV Reverse Transcriptase; HIV-1; Lymphocytes; Models, Chemical; Molecular Structure; Protein Binding; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine; Virus Replication

1998
An approach towards the synthesis of potential metal-chelating TSAO-T derivatives as bidentate inhibitors of human immunodeficiency virus type 1 reverse transcriptase.
    Antiviral chemistry & chemotherapy, 1998, Volume: 9, Issue:5

    Topics: Anti-HIV Agents; Antiviral Agents; Cell Line; Chelating Agents; HIV-1; HIV-2; Humans; Molecular Structure; Nucleosides; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Uridine; Virus Replication

1998
Novel 3'-spiro nucleoside analogues of TSAO-T. Part II. A comparative study based on NMR conformational analysis in solution and theoretical calculations.
    Antiviral chemistry & chemotherapy, 1998, Volume: 9, Issue:4

    Topics: Anti-HIV Agents; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Nucleosides; Reverse Transcriptase Inhibitors; Spiro Compounds; Static Electricity; Thymidine; Uridine

1998
Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region.
    Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25

    Topics: Anti-HIV Agents; Cell Line; Dimerization; HIV-1; HIV-2; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Fast Atom Bombardment; Spiro Compounds; Stavudine; Thymidine; Uridine; Zidovudine

1999
TSAO-T analogues bearing amino acids at position N-3 of thymine: synthesis and anti-human immunodeficiency virus activity.
    Antiviral chemistry & chemotherapy, 2000, Volume: 11, Issue:1

    Topics: Anti-HIV Agents; Cell Line; HIV-1; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Spiro Compounds; Thymidine; Thymine; Uridine; Virus Replication

2000
Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138.
    Virology, 2001, Feb-01, Volume: 280, Issue:1

    Topics: Alanine; Anti-HIV Agents; Aspartic Acid; Cell Line; Deoxyguanine Nucleotides; Dideoxynucleotides; DNA-Directed DNA Polymerase; Glutamic Acid; Glutamine; HIV Reverse Transcriptase; HIV-1; Humans; Lysine; Mutagenesis, Site-Directed; Nucleosides; Phenylalanine; Recombination, Genetic; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spiro Compounds; Thymidine; Tyrosine; Uridine

2001
Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV.
    Journal of virology, 2001, Volume: 75, Issue:13

    Topics: Anti-HIV Agents; Antimetabolites; Deoxycytosine Nucleotides; Drug Resistance, Microbial; Genome, Viral; HIV Reverse Transcriptase; HIV-1; Reverse Transcriptase Inhibitors; Spiro Compounds; Thymidine; Thymine Nucleotides; Uridine

2001
Exploring the role of the 5'-position of TSAO-T. Synthesis and anti-HIV evaluation of novel TSAO-T derivatives.
    Antiviral research, 2001, Volume: 50, Issue:3

    Topics: Antiviral Agents; Cell Line; Drug Design; HIV-1; HIV-2; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Thymine; Uridine; Virus Replication

2001
Synthesis of 3' '-substituted TSAO derivatives with anti-HIV-1 and anti-HIV-2 activity through an efficient palladium-catalyzed cross-coupling approach.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Catalysis; Cell Line; Computer Simulation; HIV-1; HIV-2; Humans; Palladium; Protein Binding; RNA-Directed DNA Polymerase; Spiro Compounds; Structure-Activity Relationship; Thermodynamics; Thymidine; Uridine

2002
Hybrids of [TSAO-T]-[foscarnet]: The first conjugate of foscarnet with a non-nucleoside reverse transcriptase inhibitor through a labile covalent ester bond.
    Journal of medicinal chemistry, 2004, Jun-17, Volume: 47, Issue:13

    Topics: Cell Extracts; Cell Line, Tumor; Drug Resistance, Viral; Drug Stability; Foscarnet; HIV Reverse Transcriptase; HIV-1; Humans; Hydrolysis; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

2004
Synthesis of novel Bi-, Tri-, and tetracyclic nucleosides by reaction of a common cyclic enamine derived from TSAO-T with nucleophiles.
    The Journal of organic chemistry, 2004, Dec-10, Volume: 69, Issue:25

    Topics: Amines; Anti-HIV Agents; Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Nucleosides; Spiro Compounds; Stereoisomerism; Thymidine; Uridine

2004
Monitor-chemistry: antiretrovirals: the first [Foscarnet]-[TSAO-T] conjugates.
    Drug discovery today, 2005, Mar-15, Volume: 10, Issue:6

    Topics: Anti-HIV Agents; Drug Resistance, Viral; Foscarnet; HIV Reverse Transcriptase; HIV-1; Spiro Compounds; Thymidine; Uridine

2005
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
    Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

    Topics: Aza Compounds; Cell Line; HIV-1; HIV-2; Humans; Models, Molecular; Molecular Conformation; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine; Virus Replication

2005
Improving the antiviral efficacy and selectivity of HIV-1 reverse transcriptase inhibitor TSAO-T by the introduction of functional groups at the N-3 position.
    Journal of medicinal chemistry, 2005, Oct-20, Volume: 48, Issue:21

    Topics: Anti-HIV Agents; Binding Sites; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Protein Binding; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

2005
Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.
    Journal of medicinal chemistry, 2006, Aug-10, Volume: 49, Issue:16

    Topics: Anti-HIV Agents; Cell Line; Combinatorial Chemistry Techniques; Dimerization; HIV Reverse Transcriptase; HIV-1; Humans; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

2006
Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach.
    Journal of medicinal chemistry, 2006, Aug-24, Volume: 49, Issue:17

    Topics: Animals; Anti-HIV Agents; Catalysis; Cattle; Dipeptidyl Peptidase 4; Drug Design; Enzyme Activation; HIV-1; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Molecular Conformation; Oligopeptides; Prodrugs; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Time Factors; Uridine; Virus Replication

2006
Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26).
    Antiviral research, 2007, Volume: 76, Issue:2

    Topics: Cell Line; Dipeptidyl Peptidase 4; HIV-1; Humans; Oligopeptides; Prodrugs; Serum; Solubility; Spiro Compounds; Thymidine; Uridine

2007
Novel N-3 substituted TSAO-T derivatives: synthesis and anti-HIV-evaluation.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:4

    Topics: Azides; Benzophenones; Cell Line; Drug Design; HIV; HIV Reverse Transcriptase; HIV-1; HIV-2; Protein Binding; Reverse Transcriptase Inhibitors; Spiro Compounds; Substrate Specificity; Thymidine; Ultraviolet Rays; Uridine; Virus Replication

2008
Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.
    Journal of medicinal chemistry, 2011, Apr-28, Volume: 54, Issue:8

    Topics: Crystallography, X-Ray; Elasticity; HIV Reverse Transcriptase; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Reverse Transcriptase Inhibitors; Spiro Compounds; Structure-Activity Relationship; Thymidine; Uridine

2011
Synthesis and in vitro activity of novel N-3 acylated TSAO-T compounds against HIV-1 and HCV.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Cell Line; Chemistry Techniques, Synthetic; Hepacivirus; Hepatitis C; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Reverse Transcriptase Inhibitors; Small Molecule Libraries; Spiro Compounds; Thymidine; Uridine

2011