Page last updated: 2024-08-17

uridine and tetrahydrouridine

uridine has been researched along with tetrahydrouridine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (91.43)	18.7374
1990's	1 (2.86)	18.2507
2000's	1 (2.86)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (2.86)	2.80

Authors

Authors	Studies
Wentworth, DF; Wolfenden, R	1
Abbasi, MM; Beisler, JA; Voytek, P; Wolpert-DeFilippes, MK	1
Gaudio, L; Kelly, CJ; Schoenemann, PT; Wodinsky, I; Yesair, DW	1
Furner, RL; Mellett, LB	1
Burchenal, JH; Currie, VE; Krakoff, IH; Mackey, RW; Tan, CT; Wong, PP; Young, CW	1
Mak, TW; Wan, CW	1
Gordon, CS; Krakoff, IH; Kreis, W; Woodcock, TM	1
Hession, C; Kreis, W; Scully, K; Soricelli, A	1
Chabner, BA; Myers, CE; Stoller, RG	1
Chen, FP; el-Dareer, SM; Hill, DL; Mellett, LB; White, V	1
Furner, RL; Herren, TC; Mellett, LB	1
Leung, K; Roy-Burman, S; Visser, DW; von Dippe, PJ	1
Mejer, J	1
Boothman, DA; Briggle, TV; Greer, S	3
DeSimone, J; Hall, L; Heller, P; Molokie, RE; Zwiers, D	1
Davis, MA; Lawrence, TS	1
Engle, KK; Higuchi, T; Liversidge, GG; Nishihata, T	1
Boothman, DA; Greer, SB; Mekras, JA	1
Allen, S; Budman, DR; Chan, K; Deere, M; Freeman, J; Henderson, V; Kreis, W; Lichtman, S; Schulman, P; Weiselberg, L	1
Avramis, VI; Powell, W	1
Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ	1
Greer, S; Perez, LM	1
Driscoll, JS; Kelley, JA; Marquez, VE; McCormack, JJ; Roth, JS	1
Briggle, TV; Greer, S; Mekras, JA; Perez, LM	1
Benjamin, RS; Bodey, GP; Brown, NS; Carter, CJ; Freireich, EJ; Hester, J; Ho, DH; McCredie, K	1
Mathews, CK; North, TW	1
Evans, DI; Layward, L; Simmonds, HA; Watson, AR; Webster, DR	1
Duran, M; Kuis, W; Rijkers, GT; Rijksen, G; Roord, JJ; Spaapen, LJ; Staal, GE; Stoop, JW; Wadman, SK; Zegers, BJ	1
Boothman, DA; Greer, S; Mekras, JA; Perez, LM	1
Jekunen, A; Vilpo, JA	1
Chabner, B; Glaubiger, DL; Poplack, DG; Riccardi, R; Wood, J	1
Beumer, JH; Doroshow, JH; Egorin, MJ; Lenz, HJ; Newman, EM; Parise, RA; Synold, TW	1
Gao, H; Pang, GZ; Rong, SQ; Wang, YX; Zhao, YH; Zhou, D	1

Trials

3 trial(s) available for uridine and tetrahydrouridine

Article	Year
Phase I evaluation of tetrahydrouridine combined with cytosine arabinoside. Cancer treatment reports, 1979, Volume: 63, Issue:8 Topics: Bone Marrow; Clinical Trials as Topic; Cytarabine; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Leukemia; Lymphoma; Middle Aged; Neoplasms; Nucleoside Deaminases; Pyrimidine Nucleosides; Tetrahydrouridine; Uridine	1979
The effect of deoxycytidine and tetrahydrouridine in purine nucleoside phosphorylase deficiency. Advances in experimental medicine and biology, 1984, Volume: 165 Pt A Topics: Amino Acid Metabolism, Inborn Errors; Clinical Trials as Topic; Deoxycytidine; Erythrocytes; Humans; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Ribonucleotides; Tetrahydrouridine; Uracil; Uridine	1984
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:2 Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Deoxycytidine; DNA Modification Methylases; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrouridine; Uridine	2008

Other Studies

32 other study(ies) available for uridine and tetrahydrouridine

Article	Year
On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase. Biochemistry, 1975, Nov-18, Volume: 14, Issue:23 Topics: Azacitidine; Binding Sites; Cytarabine; Cytidine Deaminase; Humans; Kinetics; Liver; Nucleoside Deaminases; Protein Binding; Tetrahydrouridine; Uridine	1975
Comparative studies of the cytostatic action and metabolism of 5-azacytidine and 5,6-dihydro-5-azacytidine. Cancer research, 1977, Volume: 37, Issue:7 Pt 1 Topics: Animals; Azacitidine; Cell Division; Cells, Cultured; Cytidine; Cytidine Deaminase; Deoxycytidine; Drug Synergism; Kinetics; Leukemia L1210; Oxidative Phosphorylation; Tetrahydrouridine; Thymidine; Uridine	1977
Pharmacokinetic considerations in evaluating the effects of tetrahydrouridine on 5-azacytidine chemotherapy in L1210 leukemic mice. Cancer treatment reports, 1978, Volume: 62, Issue:7 Topics: Animals; Azacitidine; Drug Therapy, Combination; Female; Infusions, Parenteral; Injections, Intraperitoneal; Leukemia L1210; Mice; Tetrahydrouridine; Uridine	1978
Kinase and deaminase activity in a variety of subcutaneous mouse tumors. Cancer research, 1975, Volume: 35, Issue:7 Topics: Adenocarcinoma; Aminohydrolases; Animals; Cell Line; Chick Embryo; Cytarabine; Freezing; Glioma; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Mice; Mice, Inbred AKR; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Osteosarcoma; Phosphotransferases; Pyrimidine Nucleotides; Sarcoma 180; Tetrahydrouridine; Uridine	1975
Effect of tetrahydrouridine on the action of 1-beta-D-arabinofuranosylcytosine in synchronized cultures of normal rat kidney cells. Cancer research, 1979, Volume: 39, Issue:10 Topics: Animals; Cell Cycle; Cell Survival; Cells, Cultured; Cytarabine; Cytidine Deaminase; DNA; Drug Synergism; Interphase; Kidney; Rats; Tetrahydrouridine; Time Factors; Uridine	1979
Tetrahydrouridine: Physiologic disposition and effect upon deamination of cytosine arabinoside in man. Cancer treatment reports, 1977, Volume: 61, Issue:7 Topics: Administration, Oral; Biological Availability; Cytarabine; Cytidine Deaminase; Deamination; Dose-Response Relationship, Drug; Drug Therapy, Combination; Half-Life; Humans; Injections, Intravenous; Neoplasms; Tetrahydrouridine; Uridine	1977
Combinations of tetrahydrouridine and cytosine arabinoside in mouse tumors. Cancer treatment reports, 1977, Volume: 61, Issue:7 Topics: Adenocarcinoma; Animals; Cytarabine; Cytidine Deaminase; Deamination; Drug Evaluation; Drug Therapy, Combination; Female; Lung Neoplasms; Mice; Neoplasms, Experimental; Phosphotransferases; Sarcoma, Experimental; Tetrahydrouridine; Tritium; Uridine	1977
Analysis of cytidine deaminase and tetrahydrouridine interaction by use of ligand techniques. Biochemical pharmacology, 1978, Jan-01, Volume: 27, Issue:1 Topics: Cytidine Deaminase; Humans; In Vitro Techniques; Kinetics; Ligands; Liver; Nucleoside Deaminases; Protein Binding; Tetrahydrouridine; Thermodynamics; Uridine	1978
Distribution of tetrahydrouridine in experimental animals. Cancer treatment reports, 1976, Volume: 60, Issue:11 Topics: Animals; Dogs; Female; Haplorhini; Intestinal Mucosa; Kidney; Liver; Male; Mice; Rats; Spleen; Tetrahydrouridine; Time Factors; Uridine	1976
Influence of tetrahydrouridine on the phosphorylation of 1-beta-D-arabinofuranosyl-cytosine (ara-C) by enzymes from solid tumors in vitro. The Journal of pharmacology and experimental therapeutics, 1975, Volume: 194, Issue:1 Topics: Adenocarcinoma; Animals; Bone Neoplasms; Cytarabine; Cytidine Deaminase; Deoxycytidine; Female; In Vitro Techniques; Kinetics; L Cells; Liver; Lung Neoplasms; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Osteosarcoma; Phosphorus; Phosphotransferases; Sarcoma 180; Spleen; Tetrahydrouridine; Uridine	1975
Deoxycytidine transport in the presence of a cytidine deaminase inhibitor and the transport of uracil in Escherichia coli B. The Journal of biological chemistry, 1975, May-25, Volume: 250, Issue:10 Topics: Adenine Phosphoribosyltransferase; Anti-Bacterial Agents; Arsenates; Biological Transport; Cyanides; Cytidine; Cytidine Deaminase; Deoxyadenosines; Deoxycytidine; Escherichia coli; Guanosine; Kinetics; Nucleoside Deaminases; Pentosyltransferases; Tetrahydrouridine; Time Factors; Uracil; Uridine	1975
The impact of selected nucleosides on the cytotoxicity of Ara-C in HL60 cells. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Cell Line; Cell Survival; Cytarabine; Cytidine; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Drug Interactions; Humans; Kinetics; Leukemia, Promyelocytic, Acute; Nucleosides; Tetrahydrouridine; Uridine	1991
Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755. Cancer research, 1987, May-01, Volume: 47, Issue:9 Topics: Animals; Antimetabolites; Chromatography, High Pressure Liquid; Cytidine Deaminase; DCMP Deaminase; Deoxycytidine; DNA; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; RNA; Tetrahydrouridine; Uridine	1987
Tetrahydrouridine, cytidine analogues, and hemoglobin F. American journal of hematology, 1985, Volume: 18, Issue:3 Topics: Agranulocytosis; Animals; Azacitidine; Cytidine Deaminase; Decitabine; Fetal Hemoglobin; Gene Expression Regulation; Globins; Granulocytes; Papio; Tetrahydrouridine; Uridine	1985
Metabolic channeling of 5-fluoro-2'-deoxycytidine utilizing inhibitors of its deamination in cell culture. Molecular pharmacology, 1985, Volume: 27, Issue:5 Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cytidine Deaminase; Deamination; Deoxycytidine; DNA; Liver Neoplasms, Experimental; Nucleoside Deaminases; RNA; Tetrahydrouridine; Uridine	1985
Selective radiosensitization and cytotoxicity of human melanoma cells using halogenated deoxycytidines and tetrahydrouridine. International journal of radiation oncology, biology, physics, 1989, Volume: 16, Issue:5 Topics: Antineoplastic Agents; Bromodeoxycytidine; Cell Line; Deoxycytidine; Fibroblasts; Humans; In Vitro Techniques; Melanoma; Radiation-Sensitizing Agents; Tetrahydrouridine; Tumor Cells, Cultured; Uridine	1989
Enhanced serum concentrations of Ara-C using suppositories containing tetrahydrouridine as a deamination inhibitor of Ara-C. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:3 Topics: Animals; Arabinofuranosyluracil; Biological Availability; Cytarabine; Deamination; Dogs; Kinetics; Salicylates; Salicylic Acid; Suppositories; Tetrahydrouridine; Uridine	1986
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies. Cancer research, 1985, Volume: 45, Issue:11 Pt 1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Cytidine Deaminase; Deoxycytidine; DNA; Female; Floxuridine; Fluorouracil; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Nucleoside Deaminases; Tetrahydrouridine; Thymidylate Synthase; Trifluridine; Uridine	1985
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma. Cancer research, 1987, May-01, Volume: 47, Issue:9 Topics: Animals; Antimetabolites; Deoxycytidine; Female; Floxuridine; Fluorouracil; Lung Neoplasms; Mice; Tetrahydrouridine; Uridine	1987
Effect of tetrahydrouridine on the clinical pharmacology of 1-beta-D-arabinofuranosylcytosine when both drugs are coinfused over three hours. Cancer research, 1988, Mar-01, Volume: 48, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cytarabine; Deamination; Female; Half-Life; Humans; Male; Middle Aged; Tetrahydrouridine; Uridine	1988
Pharmacology of combination chemotherapy of cytosine arabinoside (ara-C) and uracil arabinoside (ara-U) or tetrahydrouridine (THU) against murine leukemia L1210/0 in tumor-bearing mice. Cancer investigation, 1987, Volume: 5, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosyluracil; Cytarabine; Deamination; Leukemia L1210; Male; Mice; Tetrahydrouridine; Time Factors; Uridine	1987
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites. Cancer chemotherapy and pharmacology, 1987, Volume: 20, Issue:2 Topics: Animals; Body Temperature; Brain; Colonic Neoplasms; Cytidine; Cytidine Deaminase; Dose-Response Relationship, Drug; Female; Hypothermia; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Rats, Inbred Strains; Tetrahydrouridine; Thymidine; Uracil; Uridine; Uridine Phosphorylase	1987
Sensitization to X ray by 5-chloro-2'-deoxycytidine co-administered with tetrahydrouridine in several mammalian cell lines and studies of 2'-chloro derivatives. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:8 Topics: Animals; Bromodeoxyuridine; Cell Line; Cell Survival; Deoxycytidine; Drug Combinations; Humans; In Vitro Techniques; Radiation-Sensitizing Agents; Tetrahydrouridine; Uridine	1986
Furanose-pyranose isomerization of reduced pyrimidine and cyclic urea ribosides. Journal of medicinal chemistry, 1986, Volume: 29, Issue:11 Topics: Cytarabine; Cytidine Deaminase; Gas Chromatography-Mass Spectrometry; Gastric Acidity Determination; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Nucleoside Deaminases; Nucleosides; Tetrahydrouridine; Uridine	1986
Marked radiosensitization of cells in culture to X ray by 5-chlorodeoxycytidine coadministered with tetrahydrouridine, and inhibitors of pyrimidine biosynthesis. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:8 Topics: Animals; Aspartic Acid; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Radiation; Floxuridine; Humans; Laryngeal Neoplasms; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Tetrahydrouridine; Uridine	1984
Effects of tetrahydrouridine on the uptake and metabolism of 1-beta-D-arabinofuranosylcytosine in human normal and leukemic cells. Cancer research, 1980, Volume: 40, Issue:7 Topics: Bone Marrow; Cells, Cultured; Cytarabine; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Phosphotransferases; Tetrahydrouridine; Uridine	1980
Tetrahydrouridine specifically facilitates deoxycytidine incorporation into herpes simplex virus DNA. Journal of virology, 1981, Volume: 37, Issue:3 Topics: Cytarabine; Deoxycytidine; DNA, Viral; HeLa Cells; Simplexvirus; Tetrahydrouridine; Uridine	1981
Purine nucleoside phosphorylase (PNP) deficiency: a therapeutic challenge. Advances in experimental medicine and biology, 1984, Volume: 165 Pt A Topics: B-Lymphocytes; Deoxycytidine; Erythrocytes; Follow-Up Studies; Guanine; Humans; Infant, Newborn; Lymphocyte Activation; Male; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; T-Lymphocytes; Tetrahydrouridine; Uridine	1984
Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. Cancer research, 1984, Volume: 44, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Cricetinae; Cricetulus; DCMP Deaminase; Deoxycytidine; DNA Replication; Drug Evaluation, Preclinical; Female; Humans; Leukemia L1210; Leukemia, Experimental; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Nucleotide Deaminases; Ovary; Tetrahydrouridine; Uridine	1984
Reversal of deamination-related cytotoxicity of 5-methyl-2'-deoxycytidine by tetrahydrouridine in human leukemia cells. Journal of the National Cancer Institute, 1984, Volume: 73, Issue:5 Topics: Biotransformation; Cell Line; Cell Survival; Deoxycytidine; Humans; Kinetics; Neoplasms; Tetrahydrouridine; Uridine	1984
Influence of tetrahydrouridine on the pharmacokinetics of intrathecally administered 1-beta-D-arabinofuranosylcytosine. Cancer research, 1982, Volume: 42, Issue:5 Topics: Animals; Cytarabine; Cytidine Deaminase; Half-Life; Injections, Intravenous; Injections, Spinal; Macaca mulatta; Male; Tetrahydrouridine; Uridine	1982
Mycoplasma infection of cancer cells enhances anti-tumor effect of oxidized methylcytidines. Biochemical and biophysical research communications, 2023, 09-10, Volume: 672 Topics: Cytidine Deaminase; Deoxycytidine; Humans; Mycoplasma Infections; Neoplasms; Tetrahydrouridine; Uridine	2023