uridine has been researched along with teriflunomide in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruneau, JM; Courtin, O; Curnock, AP; Gadher, S; Hambleton, AB; Hambleton, P; Hercend, T; Kuo, EA; Morand, P; Moss, D; Robson, PA; Ruuth, E; Sautés, C; Spinella-Jaegle, S; Thomson, TA; Westwood, R; Williamson, RA; Woodward, K; Yea, CM | 1 |
| Cao, W; Morris, RE; Nair, RV | 2 |
| Czech, J; Schorlemmer, HU; Schwab, W | 1 |
| Blinder, L; Chong, AS; Finnegan, A; Gong, H; Shen, J; Williams, JW; Xu, X | 1 |
| Bruneau, JM; Fudali, C; Kuo, EA; Robson, PA; Ruuth, E; Sautès, C; Spinella-Jaegle, S; Westwood, R; Williamson, RA; Woodward, K; Yea, CM | 1 |
| Amano, Y; Kitagawa, H; Mizushima, Y; Ogata, K | 1 |
| Blinder, L; Chong, AS; Clardy, C; Foster, P; Huang, W; Liu, W; Luo, J; Ma, L; Shen, J; Williams, JA; Xiao, F; Xu, W; Xu, X | 1 |
| Czech, J; Kurrle, R; Schorlemmer, HU | 1 |
| Flao, KL; Francesconi, E; Hidden, H; Meakin, C; Millet, S; Ruuth, E; Spinella-Jaegle, S; Thomson, TA | 1 |
| Collins, M; Graves, LM; Huang, M; Mitchell, BS; Wang, Y | 1 |
| Begué-Pastor, N; Benavent, S; Burger, D; Chicheportiche, R; Dayer, JM; Gruaz, L; Kaufmann, MT | 1 |
| Guerne, PA; Magne, D; Mézin, F; Palmer, G | 1 |
| Nakayamada, S; Ra, C; Saito, K; Sawamukai, N; Tanaka, Y; Yamaoka, K | 1 |
| Azuma, A; Hoshino, T; Isohama, Y; Ito, Y; Matoyama, M; Mizushima, T; Namba, T; Tanaka, KI; Yamakawa, N | 1 |
| Bushman, LR; Chen, P; Hail, N; Rower, J | 1 |
| Jang, HS; Kerkvliet, NI; Koch, DC; Kolluri, SK; Kopparapu, PR; O'Donnell, EF; Phillips, JL; Tanguay, RL | 1 |
17 other study(ies) available for uridine and teriflunomide
| Article | Year |
|---|---|
Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound.
Topics: Amino Acid Sequence; Aniline Compounds; Animals; Binding Sites; Cell Division; Crotonates; Dihydroorotate Dehydrogenase; Growth Inhibitors; Hydroxybutyrates; Mice; Microsomes; Mitochondria; Molecular Sequence Data; Molecular Structure; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Spleen; Toluidines; Uridine | 1995 |
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine.
Topics: Aniline Compounds; Animals; Cell Division; Cell Line; Crotonates; Fibroblast Growth Factor 2; Growth Inhibitors; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Muscle, Smooth; Nitriles; Toluidines; Uridine | 1995 |
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine.
Topics: Aniline Compounds; Animals; Cell Division; Cell Line, Transformed; Crotonates; Graft Rejection; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Mice; Muscle, Smooth; Nitriles; Toluidines; Uridine | 1995 |
Effect of malononitrilamides on human bone marrow.
Topics: Aniline Compounds; Biphenyl Compounds; Bone Marrow; Cell Survival; Cells, Cultured; Crotonates; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Hydroxybutyrates; Immunosuppressive Agents; Nitriles; Toluidines; Uridine | 1996 |
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice.
Topics: Aniline Compounds; Animals; Autoimmune Diseases; Crotonates; Dihydroorotate Dehydrogenase; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymph Nodes; Lymphoproliferative Disorders; Mice; Mice, Mutant Strains; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidine Nucleotides; Toluidines; Uridine | 1997 |
Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide.
Topics: Aniline Compounds; Binding Sites; Binding, Competitive; Cell Division; Cell Membrane; Crotonates; Dihydroorotate Dehydrogenase; Humans; Hydroxybutyrates; Lymphoma; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Spleen; Toluidines; Tumor Cells, Cultured; Uridine | 1998 |
Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model.
Topics: Administration, Oral; Aniline Compounds; Animals; Antibody Specificity; Crotonates; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxybutyrates; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Nitriles; Ovalbumin; Rats; Rats, Inbred BN; Toluidines; Uridine | 1999 |
In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression.
Topics: Aniline Compounds; Animals; Cricetinae; Crotonates; Graft Rejection; Heart Transplantation; Humans; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Liver; Lymph Nodes; Mesocricetus; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nitriles; Pyrimidine Nucleotides; Rats; Rats, Inbred Lew; Spleen; Toluidines; Transplantation, Heterologous; Transplantation, Homologous; Uridine | 1999 |
The antiproliferative effect of malononitrilamides (MNAs) on vascular smooth muscle cells is antagonized by exogenous uridine.
Topics: Acrylamides; Alkynes; Aniline Compounds; Animals; Caproates; Cell Division; Crotonates; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Muscle, Smooth, Vascular; Nitriles; Platelet-Derived Growth Factor; Rats; Toluidines; Uridine | 1999 |
In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine.
Topics: Aniline Compounds; Animals; Biphenyl Compounds; Cell Membrane; Cells, Cultured; Crotonates; Dihydroorotate Dehydrogenase; Drug Antagonism; Enzyme Inhibitors; Erythrocytes; Hydroxybutyrates; Immunoglobulin G; Immunoglobulin kappa-Chains; Immunoglobulin M; Immunoglobulins; Immunosuppressive Agents; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Nitriles; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Sheep; Spleen; Toluidines; Uridine | 2002 |
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools.
Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Cycle Proteins; Cell Differentiation; Cell Division; Crotonates; Cytidine; Cytidine Triphosphate; Dihydroorotase; Drug Interactions; Gene Expression; Glycophorins; Humans; Hydroxybutyrates; Isoxazoles; K562 Cells; Leflunomide; Multienzyme Complexes; Nitriles; Pyrimidines; S Phase; Toluidines; Uridine; Uridine Triphosphate | 2002 |
The active metabolite of leflunomide, A77 1726, inhibits the production of prostaglandin E(2), matrix metalloproteinase 1 and interleukin 6 in human fibroblast-like synoviocytes.
Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Rheumatoid; Cells, Cultured; Crotonates; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hydroxybutyrates; Interleukin-6; Isoenzymes; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Nitriles; Prostaglandin-Endoperoxide Synthases; Pyrimidines; RNA, Messenger; Synovial Membrane; Toluidines; Uridine | 2003 |
The active metabolite of leflunomide, A77 1726, increases proliferation of human synovial fibroblasts in presence of IL-1beta and TNF-alpha.
Topics: Aniline Compounds; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Crotonates; Drug Synergism; Enzyme Inhibitors; Fibroblasts; Humans; Hydroxybutyrates; Interleukin-1beta; Isoxazoles; Jurkat Cells; Leflunomide; Nitriles; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Synovial Membrane; Toluidines; Tumor Necrosis Factor-alpha; Uridine | 2006 |
Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells.
Topics: Aniline Compounds; Apoptosis; Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Chronic Disease; Crotonates; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxybutyrates; Immunosuppressive Agents; Inflammation Mediators; Isoxazoles; Leflunomide; Mast Cells; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Synovial Membrane; Synovitis; Toluidines; Uridine | 2007 |
Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis.
Topics: Aniline Compounds; Animals; Bleomycin; Cells, Cultured; Crotonates; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Homeodomain Proteins; Humans; Hydroxybutyrates; Hydroxyproline; Mice; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Phenotype; Pulmonary Fibrosis; Rats; Receptors, Notch; Repressor Proteins; RNA Interference; RNA, Small Interfering; Signal Transduction; Toluidines; Transforming Growth Factor beta; Uridine; Zinc Finger E-box Binding Homeobox 2 | 2010 |
Teriflunomide encourages cytostatic and apoptotic effects in premalignant and malignant cutaneous keratinocytes.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Crotonates; Cytostatic Agents; Energy Metabolism; Epithelial Cells; Flow Cytometry; Humans; Hydroxybutyrates; Keratinocytes; Mitochondria; Nitriles; Oxygen Consumption; Precancerous Conditions; Pyrimidines; Reactive Oxygen Species; S Phase; Skin Neoplasms; Toluidines; Uridine | 2010 |
The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells.
Topics: Aniline Compounds; Cell Line, Tumor; Cell Proliferation; Crotonates; Cyclin-Dependent Kinase Inhibitor p21; Dihydroorotate Dehydrogenase; Fluoresceins; Gene Knockdown Techniques; Humans; Hydroxybutyrates; Isoxazoles; Leflunomide; Melanoma; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Proto-Oncogene Proteins c-myc; Receptors, Aryl Hydrocarbon; Signal Transduction; Succinimides; Toluidines; Uridine | 2012 |