uridine has been researched along with orotic acid in 297 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 258 (86.87) | 18.7374 |
| 1990's | 20 (6.73) | 18.2507 |
| 2000's | 9 (3.03) | 29.6817 |
| 2010's | 8 (2.69) | 24.3611 |
| 2020's | 2 (0.67) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Banholzer, P; Gröbner, W; Zöllner, N | 1 |
| de Bree, PK; Grift, J; Stoop, JW; van Gennip, AH; Wadman, SK; Zegers, BJ | 1 |
| Donohoe, J; Kolos, G; Lykke, A; Williams, JF | 1 |
| Nakayama, H; Weser, E | 1 |
| Gulen, S; Tremblay, GC | 1 |
| Bhargava, PM; Bornecque, CA; Szafarz, D; Zajdela, F | 1 |
| Brockman, RW; Nelson, JA; Rose, LM; Schabel, FM; Shaddix, SC; Williams, M | 1 |
| Anderson, KM; Chance, H; Kadohama, N | 1 |
| Tamemasa, O; Tezuka, M | 1 |
| Ferris, JP; Joshi, PC | 1 |
| Gerok, W; Keppler, D; Pausch, J | 1 |
| Brysch, B; Chorazy, M | 1 |
| Cadman, EC; Dix, DE; Handschumacher, RE | 1 |
| Germanyuk, YL; Minchenko, AG | 1 |
| Schretlen, ED; Tax, WJ; Veerkamp, JH | 1 |
| Dubinina, IG; Gershteĭn, ES; Grekhova, NV; Shapot, VS; Vornovitskaia, GI | 1 |
| Jackson, RC; Lui, MS; Weber, G | 1 |
| Handschumacher, RE; Moyer, JD | 1 |
| Dudnikova, GN | 2 |
| Castle, T; Kreamer, W; Liu, DS; Richardson, A | 1 |
| Castellani, BR; Radtke, BM; Uemura, K; Yoneda, S | 1 |
| Bernstein, J; Cortes, P; Dumler, F; Levin, NW; Venkatachalam, KK; Verghese, CP | 1 |
| Hsiao, WL; Krooth, RS; Potvin, BW | 1 |
| Buchar, E; Seifert, J | 1 |
| Fujimura, S; Shimizu, M | 1 |
| Crandall, DE; Lovatt, CJ; Tremblay, GC | 1 |
| Kaufmann, R; Kouros, M; Krämer, R; Kunz, W | 1 |
| Gröbner, W; Zöllner, N | 1 |
| Cha, S; Janeway, CM | 1 |
| Hara, Y; Tomizawa, S | 1 |
| Hemminki, K | 1 |
| Allan, PW; Bennett, LL | 1 |
| Mattersberger, J; Rosen, H; Sonnenbichler, J | 1 |
| Cortes, P; Levin, NW; Martin, PR | 1 |
| Gröbner, W; Rauch-Janssen, A; Zöllner, N | 1 |
| Grosse, G; Lindner, G; Matthies, HJ | 1 |
| Holt, JG; Nicolaisen, AK; Rogers, LE | 1 |
| Fleming, EW; Noble, EP; Tewari, S | 1 |
| Dunn, A; Harris, LS; Harris, RA | 1 |
| Kreutzberg, GW; Rieske, E; Schubert, P | 1 |
| Artemenko, NK; Freidlin, IS; Lyzlova, SN; Nersesova, LS; Petrova, TA | 1 |
| Bhargava, PM; Kumar, GK | 1 |
| Geel, SE | 1 |
| Caulfield, JA; Malamud, D; Malt, RA; Ross, JS | 1 |
| Dahnke, HG | 1 |
| De Guglielmone, AE; Duvilanski, BH; Gómez, CJ; Soto, AM | 1 |
| Jakoubek, B | 1 |
| DeLapp, NW; Karasek, MA | 1 |
| Bissonnette, R | 1 |
| Bordugo, A; Burlina, AB; Dionisi-Vici, C; Ferrari, V; Tuchman, M; Zacchello, F | 1 |
| Bennett, JE; Edman, JC; Kwon-Chung, KJ; Varma, A | 1 |
| Karkishchenko, NN; Makliakov, IuS; Stradomskiĭ, BV; Zaika, VG | 1 |
| Matthies, H; Popov, N; Staak, S; Tischmeyer, W | 1 |
| de Graaff, LH; Gruber, F; Kubicek, CP; Visser, J | 1 |
| Brusilow, SW; Finkelstein, JE; Hauser, ER; Valle, D | 1 |
| Gómez, ZM; Rathod, PK | 1 |
| Engelbrecht, C; Yngner, T | 1 |
| Engelbrecht, C; Lewan, L; Ljungquist, I; Yngner, T | 1 |
| Dorko, ME; Hayashi, TT | 1 |
| Bissonnette, R; Leblond, CP; Lee, ER; Paiement, J | 1 |
| Cortes, P; Dumler, F; Levin, NW | 1 |
| Brusilow, SW; Hauser, E | 1 |
| Hubbert, T; Khatri, A; Milhous, WK; Rathod, PK | 1 |
| Etzioni, A | 1 |
| Morishita, H; Okajima, K; Suchi, M; Wada, Y; Yazaki, M | 1 |
| Chisena, CA; Cysyk, RL; Monks, A | 1 |
| Alvarado, CS; Elsas, LJ; Jones, ME; Livingstone, LR; McKolanis, J; Ravielle, A | 1 |
| Cortes, P; Dumler, F | 1 |
| Cassady, JM; Jacobsen, LB; Morré, DJ; Putnam, JE; Sawick, DP | 1 |
| Mill, GC | 1 |
| Potapova, GI; Shapot, VS | 1 |
| Lin, RC; Snodgrass, PJ | 1 |
| Gröbner, W; Löffler, W; Reiter, S; Zöllner, N | 1 |
| Gerok, W; Pausch, J; Rasenack, J | 1 |
| Handmaker, SD; Kay, JE | 1 |
| Bass, BG; Buckley, NM; Donaldson, W; Macy, J | 1 |
| Ord, MG; Stocken, LA | 2 |
| Broucek, J; Cihák, A | 1 |
| Cihák, A; Seifertová, M; Sorm, F; Veselý, J | 1 |
| Grafstein, B; Ingoglia, NA; McEwen, BS; McQuarrie, IG | 1 |
| Carr, J; Hollingsworth, JW | 1 |
| Cihák, A; Harrap, KR; Veselý, J | 1 |
| Heuck, CC | 1 |
| Boctor, A; Grossman, A | 1 |
| Chou, SC; Conklin, KA; Schnell, JV; Siddiqui, WA | 1 |
| Hosono, R; Kuno, S | 1 |
| Benson, PF | 1 |
| Heicke, B | 1 |
| Kummer, D | 1 |
| Krowke, R; Pielsticker, K; Siebert, G | 1 |
| Hickie, JB; Kolos, G; Williams, JF | 1 |
| Donohoe, JA; Hickie, JB; Kolos, G; Williams, JF | 1 |
| Sprecher-Goldberger, S | 1 |
| Hishizawa, T; Matsudaira, H; Nakamura, C | 1 |
| Content, J | 1 |
| Doremus, HM; Jaffe, JJ | 1 |
| Plagemann, PG | 1 |
| Shashoua, VE | 2 |
| Raisz, LG; Simmons, H; Trummel, CL | 1 |
| Miyamoto, M; Terayama, H | 1 |
| Hirschberg, E; Lea, MA; Mackauf, I; Miller, S; Morris, HP | 1 |
| Dallman, PR; Siimes, MA | 1 |
| Bagnara, AS; Finch, LR | 1 |
| Gülen, S; Smith, PC; Tremblay, GC | 1 |
| Hoogenraad, NJ; Lee, DC | 1 |
| Howard, E; Tidwell, T | 1 |
| Lindsay, RH; Yu, MW | 1 |
| Bullock, J; Khalil, FL; Lea, MA; Morris, HP | 1 |
| Kessel, H; Kröger, H | 1 |
| Gambarini, AG; Lara, FJ | 1 |
| Mainwaring, WI; Smith, AE; Wilce, PA | 1 |
| De Guglielmone, AR; Duvilanski, BH; Gómez, CJ; Soto, AM | 1 |
| Gerhart, JC; O'Donovan, GA | 1 |
| Cihák, A; Sorm, F | 1 |
| Heuser, JE; Jablecki, CK; Kaufman, S | 1 |
| Hayashi, TT; MacFarlane, K | 1 |
| Hoogenraad, NJ; Kretchmer, N; Levine, RL | 1 |
| Fedorov, NA; Koreshkova, NA; Kurbanova, GN; Matveenko, VN | 1 |
| Neal, GE | 1 |
| Klein, G; Rogers, ME | 1 |
| Moutschen, J | 2 |
| Belousova, AK; Meĭren, DV | 1 |
| Hoogenraad, NJ; Kretchmer, N; Roux, JM | 1 |
| Fanburg, BL; Matsushita, S | 2 |
| Dubovsky, J; Kochakian, CD | 1 |
| Buchar, E; Obermajerová, H; Rasková, H; Seifert, J | 1 |
| Dunn, JH; Herrmann, EC; Schmidt, RR | 1 |
| Austoker, J; Cox, D; Mathias, AP | 1 |
| Gurpide, E; Tseng, JK | 1 |
| Cornell, RC; Milstein, HG; Stoughton, RB | 1 |
| Argyris, TS; Hopkinson, J | 1 |
| Booden, T; Hull, RW | 1 |
| Dewar, AJ; Winterburn, AK | 1 |
| Antoni, F; Garzó, T; Hrabák, A; Lapis, K; Mészáros, K; Szikla, C; Tompa, A | 1 |
| Fox, RM; O'Sullivan, WJ; Royse-Smith, D; Wood, MH | 1 |
| Miller, BG | 1 |
| Knott, CE; Smith, PC; Tremblay, GC | 1 |
| Witschi, H | 3 |
| Coleman, RD; Hardy, D; Hurlbert, RB; Stankovich, M | 1 |
| Decker, K; Keppler, DO; Pausch, J | 1 |
| De Guglielmone, AE; Duvilanski, BH; Soto, AM | 1 |
| Elaev, NR | 1 |
| Farber, JL; Konishi, Y; Shinozuka, H | 1 |
| Cocucci, SM; Gianani, L | 1 |
| Weser, U | 1 |
| Mizuno, S; Shirahata, S; Tano, S | 1 |
| Barka, T | 1 |
| Barr, CF; Polet, H | 1 |
| Montagnier, L | 1 |
| Bäckström, S | 1 |
| Cerna, I; Fay, PJ; Klubes, P | 1 |
| Broulik, P; Dubovsky, J; Kochakian, CD | 1 |
| Baggett, B; Miller, BG | 1 |
| Galling, G | 1 |
| Chae, CB; Dobbins, MC; Irvin, JL; Piantadosi, C | 1 |
| Gambarini, AG; Meneghini, R | 1 |
| Dawson, KM | 1 |
| Bourget, PA; Tremblay, GC | 1 |
| Matthies, H; Ott, T | 1 |
| Gibson, JE; Rao, KS; Short, RD | 1 |
| Decker, K; Domschke, W; Keppler, D; Rudigier, J | 1 |
| Hollander, VP; Mashburn, LT; Stevens, J; Stevens, YW | 1 |
| Ennis, HL; Möller, L; Selawry, OS; Wang, JJ | 1 |
| De Luca, L; Kleinman, HK; Little, EP; Wolf, G | 1 |
| Brodsky, M; Guroff, G | 1 |
| Beardmore, TD; Fox, IH; Kelley, WN; Meade, JC | 1 |
| Tryfiates, GP | 1 |
| Baserga, R; Estensen, RD; Petersen, RO | 1 |
| Cline, MJ | 1 |
| Breitman, TR; Cooper, RA; Perry, S | 1 |
| Buchowicz, J; Grzelczak, Z | 1 |
| Becroft, DM; Phillips, LI; Simmonds, A | 1 |
| Heyn, RM; Krooth, RS; Tubergen, DG | 1 |
| Caroline, DF | 1 |
| Caroline, DF; Davis, RH | 1 |
| Hayashi, TT; Shin, DH; Wiand, S | 2 |
| Kaneko, T; LePage, GA | 1 |
| Galofré, A; Kretchmer, N | 1 |
| McGowan, J; Poynter, RW; Sternberg, SS; Zedeck, MS | 1 |
| Dvorkin, B; Makman, MH; Nakagawa, S; White, A | 1 |
| De la Garza, SA; Tepperman, HM; Tepperman, J | 1 |
| Kelley, WN; Wyngaarden, JB | 1 |
| Chelbova, KV; Golovinsky, EV; Hadjiolov, AA | 1 |
| Feigelson, P; Yu, FL | 2 |
| Fedorov, NA; Matveenko, VN; Tikhonova, EF | 1 |
| Konstantinova, IM; Vorob'ev, VI | 1 |
| Lovric, A; Soutter, GB; Stapleton, T; Yu, J | 1 |
| Bradbeer, O | 1 |
| Hruska, FE | 1 |
| Guroff, G; Hogans, AF; Udenfriend, S | 1 |
| Kirby, KS; Salaman, DF | 1 |
| Cohn, DV; Detert, AC; Hamilton, JW | 1 |
| Hempstead, KW; Kopp, LE; Miech, RP; Santos, JN | 1 |
| Adelstein, SJ; Lyman, CP | 1 |
| Hori, M; Ito, E; Sawa, T; Takeuchi, T; Wakshiro, T | 1 |
| Evans, VJ; Price, FM; Rotherham, J | 1 |
| Patterson, RB; Porter, FS; Rogers, LE; Warford, LR | 1 |
| Bondy, SC; Roberts, S | 1 |
| Lindsay, RH; Romine, CJ; Wong, MY | 1 |
| Ross, C | 1 |
| Hogan, BL; Korner, A | 1 |
| Appel, SH; Silberberg, DH | 1 |
| Garvey, BI; Hayashi, TT | 1 |
| Hsü, CS; Suzuki, Y; Takahashi, Y | 1 |
| Gilbertson, DE; Michelson, EH | 1 |
| Heyn, RM; Krooth, RS; Pan, YL; Tubergen, DG; Wuu, KD | 1 |
| Cailleau, R; Reeves, WJ | 1 |
| Firkin, BG; Fox, RM; O'Sullivan, WJ | 1 |
| Tata, JR | 1 |
| Groth, DP; Jiang, N | 1 |
| de Man, JC; Noorduyn, NJ | 1 |
| Raska, K; Welch, AD; Zedeck, MS | 1 |
| Roy-Burman, P; Smith, DA; Visser, DW | 1 |
| Lucas, ZJ | 1 |
| Haggard, ME; Lockhart, LH | 1 |
| Abell, CW; DiPaolo, JA; Rosini, LA | 1 |
| Bucknall, RA; Carter, SB | 1 |
| Sandberg, AA; Weinfeld, H | 1 |
| Cohen, S; Hoober, JK | 1 |
| Reifer, I; Wasilewska, LD | 1 |
| Brown, IH; Greenstock, CL; Hunt, JW; Johns, HE | 1 |
| Gelehrter, TD; Tomkins, GM | 1 |
| Barnabei, O; Sereni, F; Sereni, LP; Tomasi, V | 1 |
| Gualerzi, C; Mangiantini, MT; Trentalance, A | 1 |
| Niemann, I; Raisz, LG | 1 |
| Cain, DF | 1 |
| Margulis, L; Thorington, G | 1 |
| Jack, I; Parker, NF; Van Der Weyden, MB | 1 |
| Fox, RM; Piper, AA | 1 |
| Altmann, GG; Leblond, CP; Uddin, M | 1 |
| Berman, P; Harley, EH | 1 |
| Banholzer, P; Barth, C; Gröbner, W; Zöllner, N | 1 |
| Berman, P; Harley, E | 1 |
| Cederbaum, SD; Naylor, EW | 1 |
| Golovinsky, E; Spassova, M | 1 |
| Harley, EH; Losman, MJ | 1 |
| Brinster, RL; Troike, DE | 1 |
| Neumeister, JA; Webster, GC | 1 |
| Harris, ML; Oberholzer, VG | 1 |
| Durschlag, RP; Robinson, JL | 1 |
| Genchev, DD | 1 |
| Genchev, DD; Hadjiolov, AA; Kermekchiev, MB | 1 |
| Hubbard, JC; Larsh, HW; Shearer, G | 1 |
| Bowers, L; Hendrich, K; Liu, H; Merkle, H; Ugurbil, K; Weisdorf, S; Wike, J | 1 |
| Fairbanks, LD; Krijt, J; Sebesta, I; Simmonds, HA | 1 |
| Davies, PM; Fairbanks, LD; Leonard, JV; Sebesta, I; Simmonds, HA | 1 |
| Daniewska-Michalska, D; Gellert, R; Kukulska, W; Motyl, T; Opechowska-Pacocha, E; Ostrowski, K; Podgurniak, M | 1 |
| Jones, ME; Traut, TW | 1 |
| Hariguchi, F; Hayashi, T; Kobayashi, N; Matsuno, T; Okada, Y; Okamoto, T | 2 |
| Hodgson, ME; Kawai, Y; Mizuno, H; Ogawa, H; Okajima, K; Suchi, M; Sumi, S; Tsuboi, T; Wada, Y | 1 |
| Lund, AE | 1 |
| Conyers, RA; Lin, Z; Pepe, S; Richards, SM; Rosenfeldt, FL | 1 |
| Allen, JC; Bonham, JR; Downing, M; Duley, JA; Fairbanks, LD; Fensom, A; Guthrie, P; Land, JM; O'Neill, D; Rittey, C; Sharrard, M; Tanner, MS | 1 |
| Arranz, JA; Burlina, A; Climent, C; Riudor, E; Rodés, M; Roig, M; Rubio, V; Sentís, M | 1 |
| Arranz, JA; Burlina, AB; Riudor, E; Rodés, M; Rubio, V; Sentís, M | 1 |
| Sumi, S | 1 |
| Egawa, H; Kikuta, H; Kobayashi, K; Nagasaka, H; Tanaka, K; Yorifuji, T | 1 |
| Gou, X; Zhang, Y | 1 |
| HOLMES, WL; PRUSOFF, WH; WELCH, AD | 1 |
| FOX, JJ; WEMPEN, I; YUNG, N | 1 |
| CRAWFORD, I; KORNBERG, A; SIMMS, ES | 1 |
| HABERMANN, V | 1 |
| STONE, JE | 1 |
| BECROFT, DM; PHILLIPS, LI | 1 |
| MANDEL, P; MICHAELIDIS, P | 1 |
| KROOTH, RS | 1 |
| MCDANIEL, EG; SPAETH, A; WINDMUELLER, HG | 1 |
| FINK, RM; PYNADATH, TI | 1 |
| COHEN, PP; KIM, S | 1 |
| KAPOOR, M; WAYGOOD, ER | 1 |
| BASCH, RS; KARNOFSKY, DA | 1 |
| DRELL, W; MICHELSON, AM; MITCHELL, HK | 1 |
| Loukanina, N; Stasolla, C; Thorpe, TA; Yeung, EC | 1 |
| Fernie, AR; Geigenberger, P; Kossmann, J; Leisse, A; Nunes-Nesi, A; Regierer, B; Springer, F; Urbanczyk-Wochniak, E; van Dongen, JT | 1 |
| Ashihara, H; Loukanina, N; Stasolla, C; Thorpe, TA; Yeung, EC | 1 |
| Engelbrecher, A; Häuser, R; Titz, B; Uetz, P | 1 |
| Bailey, CJ | 1 |
| Ashihara, H; Elhiti, M; Stasolla, C | 1 |
| Chen, M; Thelen, JJ | 1 |
| Amyes, TL; Goryanova, B; Richard, JP; Spong, K | 1 |
| Fairlamb, AH; Ong, HB; Patterson, S; Sienkiewicz, N; Wyllie, S | 1 |
| Bamshad, MJ; Carpenter, KH; Duley, JA; Henman, MG; Marshall, GA; Ooi, CY; Pinner, JR; Wilcken, B | 1 |
| Alhaddad, B; Botto, LD; Chen, MA; Colombo, R; Coughlin, CR; Descartes, M; Grűnewald, S; Kluijtmans, LA; Maranda, B; Mills, PB; Pai, EF; Pitt, J; Pontoglio, A; Potente, C; Rodenburg, R; Sampath, S; Tiller, GE; Wevers, RA; Wortmann, SB; Yuzyuk, T | 1 |
| Bao, G; Chanda, MK; Lee, CM; Martin, R; Patterson, JO; Porteus, MH; Srifa, W; Wiebking, V | 1 |
| Andersson, C; Benson, MD; Chen, ZZ; Clish, CB; Correa, A; Cruz, DE; Dailey, L; Gao, Y; Gerszten, RE; Hall, ME; Katz, DH; Ngo, D; Peterson, B; Robbins, JM; Shen, C; Shi, X; Tahir, UA; Vasan, RS; Wang, TJ; Wilson, JG; Zhao, T | 1 |
8 review(s) available for uridine and orotic acid
| Article | Year |
|---|---|
[Selective chemotherapy of hepatocellular carcinomas].
Topics: Animals; Carcinoma, Hepatocellular; Doxorubicin; Fluorouracil; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Orotic Acid; Rats; Uridine | 1978 |
[Disorders of human pyrimidine metabolism (author's transl)].
Topics: Allopurinol; Azauridine; Chemical Phenomena; Chemistry; Cytidine; Folic Acid; Humans; Infant; Male; Ornithine Carbamoyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidine Nucleotides; Pyrimidines; Uridine | 1975 |
[Methodological approaches to the study of tumor and body tissue metabolism in vitro and in vivo].
Topics: Animals; Catalysis; Enzymes; Glycolysis; Hexokinase; In Vitro Techniques; Isoenzymes; Liver; Liver Neoplasms, Experimental; Methods; Mice; Neoplasms, Experimental; Orotic Acid; Rats; RNA, Neoplasm; Substrate Specificity; Uridine; Uridine Monophosphate; Uridine Triphosphate | 1986 |
A review: biological and clinical aspects of pyrimidine metabolism.
Topics: Ammonia; Animals; Cats; Cell Transformation, Neoplastic; Cytidine; Glucose; Humans; Isoproterenol; Lectins; Lipid Metabolism; Liver Regeneration; Lymphocyte Activation; Mice; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidine Nucleotides; Rats; Salivary Glands; Thymine; Uracil Nucleotides; Urea; Uridine; Uridine Diphosphate Sugars | 1974 |
Analogs of pyrimidine and purine mononucleotide precursors as metabolic inhibitors.
Topics: Animals; Antimetabolites; Aspartic Acid; Imidazoles; Orotic Acid; Purine Nucleosides; Purine Nucleotides; Pyrazoles; Pyrimidine Nucleotides; Triazoles; Uridine | 1981 |
Uracil metabolism--UMP synthesis from orotic acid or uridine and conversion of uracil to beta-alanine: enzymes and cDNAs.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; beta-Alanine; Biological Evolution; DNA, Complementary; Humans; Molecular Sequence Data; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Peptide Synthases; Uracil; Uridine; Uridine Kinase; Uridine Monophosphate | 1996 |
[Hereditary orotic aciduria].
Topics: Administration, Oral; Diagnosis, Differential; Humans; Immune System Diseases; Multienzyme Complexes; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Prognosis; Pyrimidines; Uridine | 2000 |
Orotic aciduria and uridine monophosphate synthase: a reappraisal.
Topics: Adult; Anemia, Megaloblastic; Child; Child, Preschool; Humans; Infant; Kinetics; Metabolic Networks and Pathways; Models, Biological; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors; Uridine; Uridine Monophosphate | 2009 |
2 trial(s) available for uridine and orotic acid
| Article | Year |
|---|---|
Investigation for the characteristic anticoccidial activity of diclazuril in battery trials.
Topics: Animals; Chickens; Coccidiosis; Coccidiostats; Drug Interactions; Drug Resistance; Eimeria; Nitriles; Nucleic Acid Precursors; Orotic Acid; Poultry Diseases; Triazines; Uracil; Uridine; Uridine Diphosphate Glucose; Uridine Diphosphate N-Acetylglucosamine | 1996 |
Optimization of allopurinol challenge: sample purification, protein intake control, and the use of orotidine response as a discriminative variable improve performance of the test for diagnosing ornithine carbamoyltransferase deficiency.
Topics: Adolescent; Adult; Allopurinol; Child; Child, Preschool; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Female; Humans; Male; Middle Aged; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Proteins; ROC Curve; Sensitivity and Specificity; Uridine | 1999 |
287 other study(ies) available for uridine and orotic acid
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Effect of allopurinol on pyrimidine metabolism in human white blood cells. Role of the salvage pathway.
Topics: Allopurinol; Humans; Leukocytes; Orotic Acid; Oxypurinol; Phosphoribosyl Pyrophosphate; Uridine | 1979 |
Urinary excretion of orotic acid, orotidine and other pyrimidines in a patient with purine nucleoside phosphorylase deficiency.
Topics: Allopurinol; Child; Child, Preschool; Chromatography, High Pressure Liquid; Deoxycytidine; Humans; Infant; Ornithine Carbamoyltransferase Deficiency Disease; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Respiratory Tract Infections; Uracil; Uridine | 1979 |
Studies using orotic acid for improving the controlled development of myocardial hypertrophy.
Topics: Animals; Cardiomegaly; Energy Metabolism; Glycogen; Leucine; Male; Myocardial Contraction; Myocardium; Orotic Acid; Protein Biosynthesis; Rats; Uracil; Uridine | 1976 |
Pyrimidine biosynthetic enzymes in rat intestine after small bowel resection.
Topics: Adaptation, Physiological; Amidohydrolases; Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbon Radioisotopes; DNA; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Orotic Acid; Phosphotransferases; Pyrimidines; Rats; Thymidine; Thymidine Kinase; Time Factors; Tritium; Uridine | 1975 |
Pyrimidine biosynthesis and its regulation in the estrogen-stimulated chick oviduct.
Topics: Animals; Aspartate Carbamoyltransferase; Azauridine; Bicarbonates; Carbon Radioisotopes; Chickens; Diethylstilbestrol; DNA; Female; Guanosine; Kinetics; Orotic Acid; Oviducts; Phosphotransferases; Pyrimidines; RNA; Uridine | 1975 |
Uptake in vitro of nucleic acid precursors and nucleic acids by Zajdela ascitic hepatoma cells.
Topics: Adenine; Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; DNA; DNA, Bacterial; Liver; Liver Neoplasms; Orotic Acid; Rats; Ribonucleosides; RNA; RNA, Bacterial; Uracil; Uridine | 1975 |
The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine.
Topics: 3-Deazauridine; Adenocarcinoma; Animals; Cell Line; Cytarabine; Deoxycytidine; Deoxyribonucleotides; DNA, Neoplasm; Drug Resistance; Leukemia L1210; Liver; Mice; Neoplasms, Experimental; Orotic Acid; Phosphotransferases; Pyrimidine Nucleotides; Ribonucleotide Reductases; Ribonucleotides; RNA, Neoplasm; Uracil Nucleotides; Uridine | 1975 |
Separation of transcriptionally active from less active rat ventral prostate chromatin.
Topics: Animals; Cell Nucleus; Chromatin; DNA; DNA-Directed RNA Polymerases; Heterochromatin; Histones; Liver; Male; Orotic Acid; Phosphoric Monoester Hydrolases; Prostate; Protein Denaturation; Rats; RNA; Testosterone; Transcription, Genetic; Uridine | 1975 |
Incorporation characteristics of uracil, uridine, and orotic acid into ribonucleic acid of neoplastic cells.
Topics: Adult; Aged; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Female; Humans; Liver; Liver Neoplasms; Male; Mice; Middle Aged; Orotic Acid; RNA, Neoplasm; Sarcoma, Experimental; Stomach Neoplasms; Uracil; Uridine; Uridine Kinase; Uridine Phosphorylase | 1977 |
Chemical evolution from hydrogen cyanide: photochemical decarboxylation of orotic acid and orotate derivatives.
Topics: Decarboxylation; Hydrogen Cyanide; Orotic Acid; Photochemistry; Ribonucleotides; Uracil; Uridine; Uridine Monophosphate | 1978 |
Isolation and properties of poly(A)-containing RNA from the cytoplasm of rat liver cells.
Topics: Adenine Nucleotides; Adenosine; Animals; Carbon Radioisotopes; Cells, Cultured; Chromatography, Affinity; Chromatography, Gel; Cytoplasm; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Hydrogen-Ion Concentration; Liver; Methods; Nucleic Acid Denaturation; Nucleotides; Orotic Acid; Phosphates; Phosphorus Radioisotopes; Poly A-U; Polynucleotides; Rats; RNA; Temperature; Tritium; Ultrafiltration; Uridine | 1975 |
Clinical, biological, and biochemical effect of pyrazofurin.
Topics: Adolescent; Adult; Aged; Amides; Animals; Carcinoma 256, Walker; Cell Division; Cell Line; Female; Humans; In Vitro Techniques; Leukemia, Experimental; Leukemia, Myeloid, Acute; Male; Mice; Middle Aged; Mouth Mucosa; Neoplasms; Orotic Acid; Pyrazoles; Pyrimidine Nucleotides; Ribonucleosides; Ribose; Uridine | 1978 |
Effect of insulin on RNA and protein biosynthesis in liver mitochondria from normal and alloxan diabetic rats.
Topics: Animals; Cytoplasm; Diabetes Mellitus, Experimental; DNA; Insulin; Leucine; Male; Mitochondria, Liver; Orotic Acid; Protein Biosynthesis; Rats; RNA; Uridine | 1978 |
The urinary excretion of orotic acid and orotidine, measured by an isotope dilution assay.
Topics: Adolescent; Adult; Aging; Allopurinol; Breast Feeding; Child; Female; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Infant, Newborn; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Pregnancy; Radioisotope Dilution Technique; Uridine | 1978 |
[Change in the correlation of 2 RNA precursor synthesis pathways in the tissues of animals with rapidly growing hepatomas].
Topics: Animals; Liver; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Nucleic Acid Precursors; Orotic Acid; Rats; RNA, Neoplasm; Spleen; Thymus Gland; Uridine | 1979 |
Enzyme pattern-directed chemotherapy. Effects of antipyrimidine combinations on the ribonucleotide content of hepatomas.
Topics: 3-Deazauridine; Animals; Antibiotics, Antineoplastic; Drug Therapy, Combination; Galactosamine; In Vitro Techniques; Liver Neoplasms, Experimental; Male; Orotic Acid; Rats; Ribonucleosides; Ribonucleotides; Uridine | 1979 |
Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Female; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Organophosphorus Compounds; Orotic Acid; Phosphonoacetic Acid; Pyrazoles; Pyrimidine Nucleotides; Pyrimidines; Ribonucleosides; Uridine | 1979 |
[Autoradiographic analysis of the effect of potassium orotate on the intensity of uridine-5 3H and proline-3H incorporation into wound fibroblasts].
Topics: Animals; Autoradiography; Biological Transport; Fibroblasts; Mice; Orotic Acid; Proline; Protein Biosynthesis; RNA; Tritium; Uridine; Wounds, Stab | 1979 |
Characterization of RNA synthesis by isolated hepatocytes in suspension.
Topics: Animals; Cell Nucleus; Dactinomycin; Female; In Vitro Techniques; Kinetics; Liver; Orotic Acid; Poly A; Rats; RNA; Transcription, Genetic; Uracil; Uridine | 1979 |
Autoradiographic study on the pyrimidine metabolism of Toxoplasma gondii, in its extracellular forms.
Topics: Animals; Autoradiography; Culture Media; Mice; Orotic Acid; Toxoplasma; Uridine | 1979 |
Incorporation of exogenous precursors into uridine nucleotides and ribonucleic acid. Nucleotide compartmentation in the renal cortex in vivo.
Topics: Animals; Cell Compartmentation; Kidney Cortex; Liver; Male; Models, Biological; Orotic Acid; Rats; RNA; Spleen; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars; Uridine Triphosphate | 1979 |
Resistance to 5-fluoroorotic acid and pyrimidine auxotrophy: a new bidirectional selective system for mammalian cells.
Topics: Animals; Clone Cells; Culture Media; Drug Resistance; Leukemia, Experimental; Mice; Orotic Acid; Phenotype; Uridine | 1979 |
Alterations in metabolism of cytidine components in rat liver after oral administration of butylated hydroxytoluene (in vivo study).
Topics: Animals; Butylated Hydroxytoluene; Cytidine; Lipid Metabolism; Liver; Male; Orotic Acid; Pyrimidine Nucleotides; Rats; RNA; Time Factors; Uridine | 1979 |
Studies on the abnormal excretion of pyrimidine nucleosides in the urine of Yoshida ascites sarcoma-bearing rats. Increased excretion of deoxycytidine, pseudouridine and cytidine.
Topics: Animals; Cytidine; Deoxycytidine; Liver; Male; Neoplasm Transplantation; Orotic Acid; Pseudouridine; Pyrimidine Nucleosides; Rats; Sarcoma, Yoshida; Uridine | 1978 |
Regulation of pyrimidine biosynthesis by purine and pyrimidine nucleosides in slices of rat tissue.
Topics: Adenosine; Ammonia; Animals; Bicarbonates; Cytidine; In Vitro Techniques; Liver; Male; Orotic Acid; Pyrimidines; Rats; Ribonucleosides; Spleen; Uridine | 1978 |
[Autoradiographic study of stimulation of RNA synthesis in fibroblasts].
Topics: Animals; Cell Nucleus; Cytoplasm; Fibroblasts; Granulation Tissue; Mice; Muscles; Orotic Acid; RNA; Skin; Stimulation, Chemical; Uridine; Wound Healing | 1978 |
Effect of halothane inhalation on orotic acid uptake and uridine incorporation into mouse liver RNA.
Topics: Aerosols; Animals; Halothane; In Vitro Techniques; Liver; Male; Mice; Orotic Acid; RNA; Time Factors; Uridine | 1978 |
Effects of 6-azauridine on nucleotides, orotic acid, and orotidine in L5178Y mouse lymphoma cells in vitro.
Topics: Azauridine; Cells, Cultured; Lymphoma; Neoplasms, Experimental; Nucleotides; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine Nucleotides; Pyrimidine Nucleotides; Uridine | 1977 |
[The antigranuloma effect of fluocinolone acetonide by paper disk granuloma in rats (author's transl)].
Topics: Adrenalectomy; Animals; Disease Models, Animal; DNA; Female; Fluocinolone Acetonide; Granuloma; In Vitro Techniques; Leucine; Methods; Orotic Acid; Paper; Protein Biosynthesis; Puromycin; Rats; RNA; Thymidine; Uridine | 1977 |
RNA metabolism in chick oviduct during oestrogen stimulation.
Topics: Animals; Cell Nucleus; Chickens; Cytoplasm; Estradiol; Female; Hydroxyurea; Orotic Acid; Oviducts; RNA; Uridine | 1976 |
Metabolism and metabolic effects of 8-azainosine and 8-azaadenosine.
Topics: Adenosine; Animals; Azaguanine; Cell Line; Chromatography, Thin Layer; Humans; In Vitro Techniques; Inosine; Mice; Orotic Acid; Polynucleotides; Purines; Pyrimidine Nucleotides; Thymidine; Uridine | 1976 |
[Stimulation of RNA synthesis in rat liver and isolated hepatocytes by silybin, an antihepatotoxic agent from Silybum marianum L. Gaertn (author's transl)].
Topics: Animals; Cell Nucleus; Cells, Cultured; Cytoplasm; Dose-Response Relationship, Drug; Flavonoids; Liver; Male; Orotic Acid; Rats; RNA; Silymarin; Time Factors; Uridine | 1976 |
Ribonucleic acid synthesis in the renal cortex at the initiation of compensatory growth.
Topics: Animals; Chromatography, Liquid; DNA; In Vitro Techniques; Kidney; Kidney Cortex; Male; Nephrectomy; Orotic Acid; Rats; Ribosemonophosphates; RNA; Time Factors; Uracil Nucleotides; Uridine | 1976 |
[The effect of various purine and pyrimidine derivatives on human pyrimidine synthesis].
Topics: Adenosine Monophosphate; Allopurinol; Humans; Hypoxanthines; Orotic Acid; Pyrimidines; Uridine | 1976 |
[Effect of orotic acid on the in vitro cultured nerve tissue].
Topics: Animals; Cell Differentiation; Cell Division; Cell Survival; Chick Embryo; Culture Media; Culture Techniques; Hippocampus; Neurons; Orotic Acid; Rats; Trigeminal Ganglion; Uridine | 1976 |
Hereditary orotic aciduria: results of a screening survey.
Topics: Adult; Carboxy-Lyases; Carboxylic Acids; Erythrocytes; Female; Heterozygote; Humans; Intellectual Disability; Male; Orotic Acid; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidine Nucleotides; Ribonucleotides; Uracil Nucleotides; Uridine | 1975 |
Alterations in brain RNA metabolism following chronic ethanol ingestion.
Topics: Animals; Brain; Cell Nucleus; Ethanol; Mice; Mice, Inbred Strains; Orotic Acid; Polyribosomes; Ribosomes; RNA; Subcellular Fractions; Time Factors; Uridine | 1975 |
Effect of narcotic drugs on ribonucleic acid and nucleotide metabolism in mouse brain.
Topics: Animals; Brain; Food Deprivation; Liver; Male; Mice; Morphine; Naloxone; Narcotics; Orotic Acid; Pentazocine; RNA; Uracil Nucleotides; Uridine | 1975 |
Transfer of radioactive material between electrically coupled neurons of the leech central nervous system.
Topics: Animals; Autoradiography; Biological Transport; Central Nervous System; Depression, Chemical; Fucose; Ganglia; Glucosamine; Glycine; Iontophoresis; Leeches; Leucine; Neurons; Orotic Acid; Puromycin; RNA; Synapses; Tritium; Uridine | 1975 |
[Changes in the functional activity of macrophages, their morphology and metabolism under the influence of several biologically active substances].
Topics: Ascorbic Acid; Carbon Radioisotopes; Cathepsins; Chloramphenicol; Chloroquine; Creatine Kinase; Culture Techniques; Cycloheximide; Dactinomycin; Lipopolysaccharides; Lysine; Macrophages; Orotic Acid; Peritoneum; Phagocytosis; Protein Biosynthesis; Puromycin; Rifampin; RNA; Tetracycline; Uridine | 1975 |
Comparison of some permeability properties of rat liver slices, liver cells in suspension, and in vivo-produced aggregates of dispersed liver cells.
Topics: Animals; Biological Transport, Active; Cell Aggregation; DNA, Bacterial; Female; In Vitro Techniques; Liver; Male; Nucleic Acids; Orotic Acid; Permeability; Rats; Ribonucleases; RNA, Bacterial; Uracil; Uridine | 1975 |
Neonatal hypothyroidism: enhanced incorporation of precursors into cerebral RNA in vivo and normalizing effect of a semi-acute injection of thyroxine.
Topics: Animals; Biological Transport; Cerebral Cortex; Female; Hypothyroidism; Male; Orotic Acid; Rats; RNA; RNA, Ribosomal; Thyroxine; Transcription, Genetic; Uridine | 1975 |
Differential labeling with orotic acid and uridine in compensatroy renal hypertrophy.
Topics: Animals; DNA; Hypertrophy; Isotope Labeling; Kidney; Kidney Tubules; Male; Mice; Nephrectomy; Orotic Acid; RNA; Uridine | 1975 |
[Problems associated with the labelling of RNA with radioactive precursors in vivo (author's transl)].
Topics: Animals; Brain; Cytidine; DNA; Isotope Labeling; Kinetics; Liver; Male; Muscles; Organ Specificity; Orotic Acid; Protein Biosynthesis; Rats; RNA; Uridine | 1975 |
Age-dependent changes of uridine nucleotide and RNA metabolism in the brain of normal and hypothyroid rats.
Topics: Age Factors; Animals; Brain; Hypothyroidism; Orotic Acid; Rats; RNA; Thyroid Gland; Thyroidectomy; Uridine | 1975 |
Topographical differences of RNA labelling in rat brain after intraventricular administration of labelled RNA precursors.
Topics: Animals; Autoradiography; Brain; Cerebral Ventricles; Ependyma; Injections, Intraventricular; Male; Meninges; Orotic Acid; Rats; RNA; Uridine | 1976 |
Importance of pyrimidine nucleotide salvage pathways for DNA synthesis in skin.
Topics: Animals; Animals, Newborn; Azauridine; Cytidine; DNA; Hydroxyurea; Liver; Methotrexate; Mice; Orotic Acid; Pyrimidine Nucleotides; Rabbits; RNA; Skin; Thymidine; Time Factors; Uridine | 1976 |
The de novo and salvage pathways for the synthesis of pyrimidine residues of RNA predominate in different locations within the mouse duodenal epithelium.
Topics: Animals; Autoradiography; Cell Differentiation; Duodenum; Epithelial Cells; Epithelium; Mice; Orotic Acid; Pyrimidines; RNA; Uridine | 1992 |
Allopurinol challenge test in children.
Topics: Adolescent; Aging; Allopurinol; Child; Child, Preschool; Citrulline; Female; Humans; Infant; Male; Metabolism, Inborn Errors; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Urea; Uridine | 1992 |
Selection of ura5 and ura3 mutants from the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium.
Topics: Animals; Blotting, Southern; Cryptococcus neoformans; Culture Media; Deoxyribonuclease EcoRI; Deoxyribonucleases, Type II Site-Specific; DNA, Fungal; Humans; Mutation; Nucleic Acid Hybridization; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Restriction Mapping; Transformation, Genetic; Uracil; Uridine | 1992 |
[Biosynthesis of biogenic pyrimidines in anxiety and depressive states of different etiologies].
Topics: Adolescent; Adult; Anxiety Disorders; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Orotic Acid; Schizophrenia; Schizophrenic Psychology; Uridine | 1991 |
Metabolization of a retention-improving dosage of methylglucamine orotate in rat brain.
Topics: Animals; Brain Chemistry; Male; Meglumine; Orotic Acid; Rats; Rats, Inbred Strains; RNA; Sorbitol; Uridine | 1990 |
The development of a heterologous transformation system for the cellulolytic fungus Trichoderma reesei based on a pyrG-negative mutant strain.
Topics: Blotting, Southern; Chromatography, Thin Layer; Drug Resistance, Microbial; Genes, Fungal; Mutation; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Transformation, Genetic; Trichoderma; Uridine | 1990 |
Allopurinol-induced orotidinuria. A test for mutations at the ornithine carbamoyltransferase locus in women.
Topics: Adult; Allopurinol; Chromatography, High Pressure Liquid; Female; Genetic Carrier Screening; Heterozygote; Humans; Middle Aged; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Uridine | 1990 |
Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice.
Topics: Animals; Drug Combinations; Malaria; Male; Mice; Orotic Acid; Plasmodium yoelii; Uridine | 1990 |
Metabolism of uridine and determination of liver ribonucleic acid synthesis in developing and adult mice.
Topics: Aging; Alanine; Animals; beta-Alanine; Liver; Male; Mice; Orotic Acid; RNA; Tritium; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate | 1985 |
Utilization of labelled uridine, cytidine and orotic acid for determination of ribonucleic acid synthesis in mouse liver.
Topics: Animals; Cytidine; Liver; Male; Mice; Orotic Acid; RNA; Uridine | 1985 |
Incorporation of labeled ribonucleic acid precursors into maternal and fetal rat tissues during pregnancy.
Topics: Animals; Cytidine; Female; Fetus; Injections, Intravenous; Maternal-Fetal Exchange; Nucleic Acid Precursors; Orotic Acid; Placenta; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; RNA; Tritium; Uridine | 1986 |
Radioautographic comparison of RNA synthesis patterns in the epithelial cells of mouse pyloric antrum following 3H-uridine and 3H-orotic acid injections.
Topics: Animals; Autoradiography; Cell Differentiation; Cell Nucleus; Epithelial Cells; Epithelium; Male; Mice; Microscopy, Electron; Orotic Acid; Pyloric Antrum; RNA; Uridine | 1987 |
Glomerular uracil nucleotide synthesis.
Topics: Animals; Kidney Glomerulus; Kinetics; Male; Models, Biological; Orotic Acid; Rats; Rats, Inbred F344; RNA; Uracil Nucleotides; Uridine; Uridine Phosphorylase; Uridine Triphosphate | 1988 |
Simple method of measurement of orotic acid and orotidine in urine.
Topics: Chromatography, High Pressure Liquid; Humans; Nitrobenzoates; Orotic Acid; Spectrophotometry, Ultraviolet; Uridine | 1989 |
Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Cell Survival; Cells, Cultured; Chloroquine; Humans; Orotic Acid; Plasmodium falciparum; Tumor Cells, Cultured; Uridine | 1989 |
Hypogammaglobulinemia in orotic aciduria.
Topics: Agammaglobulinemia; Humans; Infant; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Uridine | 1989 |
Increase of protein synthesis by uridine supplement in lectin-stimulated peripheral blood lymphocytes and EB virus-transformed B cell line of hereditary orotic aciduria type I.
Topics: Antigens, Surface; Cell Transformation, Viral; Female; Herpesvirus 4, Human; Humans; Infant; Lectins; Lymphocyte Activation; Lymphocytes; Metabolism, Inborn Errors; Orotic Acid; Protein Biosynthesis; Uridine | 1987 |
Influence of ammonium ions on hepatic de novo pyrimidine biosynthesis.
Topics: Ammonia; Ammonium Chloride; Animals; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Chromatography, High Pressure Liquid; Glutamine; In Vitro Techniques; Liver; Male; Orotic Acid; Perfusion; Pyrimidines; Rats; Rats, Inbred Strains; Sodium Bicarbonate; Uridine; Uridine Monophosphate; Uridine Triphosphate | 1985 |
Uridine-responsive hypogammaglobulinemia and congenital heart disease in a patient with hereditary orotic aciduria.
Topics: Agammaglobulinemia; Carboxy-Lyases; Child, Preschool; Female; Heart Septal Defects, Atrial; Humans; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Pulmonary Valve Stenosis; Uridine | 1988 |
Uracil ribonucleotide metabolism in rat and human glomerular epithelial and mesangial cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Epithelium; Glomerular Mesangium; Humans; Kidney Cortex; Kidney Glomerulus; Kinetics; Male; Organ Specificity; Orotic Acid; Rats; Rats, Inbred F344; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1988 |
Pyrimidine nucleosides enhance the efficacy of inhibitors of pyrimidine biosynthesis in cultured hepatocellular carcinoma cells.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Cell Division; Cytidine; Liver Neoplasms, Experimental; Organophosphorus Compounds; Orotic Acid; Phosphonoacetic Acid; Pyrimidine Nucleosides; Pyrimidines; Rats; Tumor Cells, Cultured; Uridine | 1988 |
Urinary purines, pyrimidines and nucleosides in uridine-treated orotic aciduria.
Topics: Adolescent; Adult; Child; Chromatography, Ion Exchange; Humans; Male; Nucleosides; Orotic Acid; Purines; Pyrimidines; Uracil; Uridine | 1988 |
Differing effects of arginine deficiency on the urea cycle enzymes of rat liver, cultured hepatocytes and hepatoma cells.
Topics: Ammonium Chloride; Animals; Arginase; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred ICR; Ornithine Carbamoyltransferase; Orotic Acid; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Urea; Uridine; Valine | 1987 |
Urinary oxipurinol-1-riboside excretion and allopurinol-induced oroticaciduria.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Humans; Orotic Acid; Purines; Ribonucleosides; Uridine | 1986 |
De novo pyrimidine biosynthesis in isolated rat hepatocytes. Quantitative aspects of the regulation by UTP.
Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Cytidine Triphosphate; Dose-Response Relationship, Drug; Female; Galactosamine; Guanosine Triphosphate; Liver; Mathematics; Orotic Acid; Pyrimidines; Rats; Rats, Inbred Strains; Uracil Nucleotides; Uridine; Uridine Monophosphate; Uridine Triphosphate | 1985 |
Uridine incorporation and RNA synthesis during stimulation of lymphocytes by PHA.
Topics: Aspartic Acid; Cycloheximide; Dactinomycin; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Orotic Acid; Phosphotransferases; Prostaglandins; RNA; Stimulation, Chemical; Time Factors; Tritium; Uridine | 1970 |
Effects of pyrimidine compounds on atrial and ventricular excitability.
Topics: Animals; Atrial Function; Blood Pressure; Depression, Chemical; Dogs; Electric Stimulation; Heart Atria; Heart Ventricles; Muscle Contraction; Nucleosides; Orotic Acid; Stimulation, Chemical; Uridine; Ventricular Function | 1971 |
Uptake of amino acids and nucleic acid precursors by regenerating rat liver.
Topics: Adenine; Adrenalectomy; Amino Acids; Animals; Dactinomycin; Hepatectomy; Liver; Liver Regeneration; Lysine; Male; Ornithine; Orotic Acid; Phenylalanine; Rats; RNA; Thymidine; Tritium; Tyrosine; Uridine; Valine | 1972 |
Dual effect of 5-azacytidine on the synthesis of liver ribonucleic acids. Lack of the relationship between metabolic transformation of orotic acid in vitro and its incorporation in vivo.
Topics: Animals; Azacitidine; Biotransformation; Carbon Isotopes; Carboxy-Lyases; Cell-Free System; Cytidine; In Vitro Techniques; Isotope Labeling; Liver; Orotic Acid; Pentosyltransferases; Phosphotransferases; Rats; RNA; RNA, Ribosomal; RNA, Transfer; Time Factors; Triazines; Uridine | 1972 |
Metabolic alterations of liver regeneration. 8. Enhanced synthesis of DNA in the liver of 5-azacytidine-treated rats subjected to partial hepatectomy.
Topics: Animals; Autoradiography; Azacitidine; Carbon Isotopes; Cell Division; Cytidine; Depression, Chemical; DNA; Female; Hepatectomy; Liver; Liver Regeneration; Methods; Orotic Acid; Pyrimidine Nucleotides; Rats; RNA; Stimulation, Chemical; Thymine Nucleotides; Time Factors; Triazines; Tritium; Uridine | 1972 |
Axonal transport of radioactivity in the goldfish optic system following intraocular injection of labelled RNA precursors.
Topics: Animals; Axonal Transport; Carbon Isotopes; Cyprinidae; Eye; Guanosine; Kinetics; Nerve Regeneration; Nerve Tissue Proteins; Optic Nerve; Orotic Acid; Retina; RNA; Superior Colliculi; Tritium; Uridine | 1973 |
3H-uridine incorporation as a T lymphocyte indicator in the rat.
Topics: Adenine; Adenosine; Animals; Ascitic Fluid; Autoradiography; Cycloheximide; Cytidine; Dactinomycin; Female; Lymphocyte Depletion; Lymphopenia; Male; Orotic Acid; Phosphorus Isotopes; Polyethylenes; Puromycin; Rats; Rats, Inbred Strains; T-Lymphocytes; Thoracic Duct; Tritium; Uridine | 1973 |
Enhancement of rat liver uridine kinase activity by various metabolic inhibitors.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Azacitidine; Azauridine; Carbon Radioisotopes; Cell-Free System; Cycloheximide; Dactinomycin; Daunorubicin; Diet; Doxorubicin; In Vitro Techniques; Liver; Male; Orotic Acid; Phosphotransferases; Puromycin; Pyrimidines; Rats; Stimulation, Chemical; Thioacetamide; Thymus Gland; Uridine | 1974 |
RNA synthesis in islets of Langerhans from rats during glucose stimulation in vivo and in vitro.
Topics: Animals; Biological Transport; Dactinomycin; Glucose; In Vitro Techniques; Islets of Langerhans; Male; Molecular Weight; Orotic Acid; Rats; RNA; Stimulation, Chemical; Uridine | 1973 |
Differential sensitivity of rat liver and rat hepatoma cells to alpha-amanitin.
Topics: Adrenalectomy; Animals; Basidiomycota; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Dactinomycin; DNA-Directed RNA Polymerases; Enzyme Induction; Hydrocortisone; Liver; Liver Neoplasms; Mycotoxins; Nucleotides; Oligopeptides; Orotic Acid; Peptides, Cyclic; Rats; Tritium; Tyrosine Transaminase; Uracil; Uridine | 1973 |
DNA and RNA syntheses by intraerythrocytic stages of Plasmodium knowlesi.
Topics: Adenosine; Animals; Carbon Radioisotopes; Cell Count; DNA; Erythrocytes; Haplorhini; Macaca; Malaria; Orotic Acid; Periodicity; Plasmodium; RNA; Spectrum Analysis; Thymidine; Time Factors; Uridine | 1973 |
Mechanism of inhibition of bacterial growth by adenine.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Bacterial Proteins; Carbon Radioisotopes; Culture Media; Depression, Chemical; DNA, Bacterial; Edetic Acid; Escherichia coli; Guanosine; Inosine; Orotic Acid; Oxygen Consumption; Phosphorus Radioisotopes; Purine Nucleotides; Pyrimidine Nucleotides; RNA, Bacterial; Uridine | 1974 |
Protein and RNA synthesis in trisomic Down's syndrome leucocytes.
Topics: Acid Phosphatase; Alkaline Phosphatase; Carbon Isotopes; Child; Down Syndrome; Glucosephosphate Dehydrogenase; Glycine; Humans; Leukocytes; Nucleotidases; Nucleotidyltransferases; Orotic Acid; Protein Biosynthesis; RNA; Trisomy; Tritium; Uridine | 1967 |
[Inhibition of DNA synthesis and cell multiplication by apurinic acid and apyrimidinic acid].
Topics: Aldehydes; Animals; Boron Compounds; Carbon Isotopes; Cell Division; Culture Techniques; Depression, Chemical; DNA, Neoplasm; Lymphocytes; Lymphoma; Mice; Nucleotides; Orotic Acid; Phenylalanine; Thymidine; Tritium; Uridine | 1970 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
A simple fractionation procedure for studying incorporation of radioactively labelled precursors into mammalian main cell components.
Topics: Animals; Carbon Isotopes; Cells; DNA; Embryo, Mammalian; Glycosaminoglycans; Lipids; Orotic Acid; Phenylalanine; Proteins; Rats; RNA; Sulfur Isotopes; Thymidine; Tritium; Uridine | 1971 |
Biochemical studies in myocardial hypertrophy and metabolic support of the acutely stressed myocardium.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cardiomegaly; Creatine Kinase; Heart; Hypertrophy; L-Lactate Dehydrogenase; Leucine; Male; Microscopy, Electron; Muscle Tonus; Muscles; Myocardium; Orotic Acid; Papillary Muscles; Rats; Time Factors; Uridine; Vitamin B 12 | 1974 |
The action of orotic acid as a positive inotropic agent during the acute phase of myocardial hypertrophy.
Topics: Acute Disease; Animals; Cardiomegaly; Folic Acid; Leucine; Male; Myocardial Contraction; Myocardium; Orotic Acid; Protein Biosynthesis; Rats; Stimulation, Chemical; Uridine; Vitamin B 12 | 1974 |
The existence of two different metabolic patterns for the synthesis of RNA viruses.
Topics: Adenine; Animals; Antimetabolites; Chick Embryo; Culture Media; Dactinomycin; Enterovirus; Fibroblasts; Formates; Histones; Influenza A virus; Methotrexate; Nucleosides; Orotic Acid; Phenylalanine; Puromycin; Radiation Effects; RNA Viruses; RNA, Viral; Thymidine; Ultraviolet Rays; Uridine | 1966 |
Some characteristics in the pathway of RNA synthesis in hepatoma cells.
Topics: Animals; Ascites; Autoradiography; Carbon Isotopes; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Neoplasms, Experimental; Nucleotidyltransferases; Orotic Acid; p-Dimethylaminoazobenzene; Phosphotransferases; Rats; RNA, Neoplasm; Sarcoma, Yoshida; Transferases; Tritium; Uridine | 1968 |
Virus growth inhibition by ethidium chloride and other dyes.
Topics: Acridines; Animals; Carbon Isotopes; Chick Embryo; Coloring Agents; Culture Techniques; Dactinomycin; Encephalitis Viruses; Encephalomyocarditis virus; Fibroblasts; Herpesviridae; Influenza A virus; Light; Newcastle disease virus; Orotic Acid; Poliovirus; Uridine; Vaccinia virus; Virus Replication | 1969 |
Metabolic patterns of Dirofilaria immitis microfilariae in vitro.
Topics: Adenine; Amino Acids; Animals; Benzenesulfonates; Carbon Dioxide; Carbon Isotopes; Diethylcarbamazine; Dithiazanine; DNA; Filarioidea; Formates; Glucose; Glycine; Glycogen; In Vitro Techniques; Lipid Metabolism; Orotic Acid; Proteins; RNA; Uracil; Uridine | 1970 |
Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. I. Kinetics of incorporation of nucleosides into nucleotide pools and pool sizes during growth cycle.
Topics: Animals; Aspartic Acid; Biological Transport; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Chromatography, Paper; Culture Media; Culture Techniques; Diffusion; DNA; Electrophoresis; Hypoxanthines; Kinetics; Liver Neoplasms; Neoplasms, Experimental; Nucleosides; Nucleotides; Orotic Acid; Rats; RNA; Thymidine; Time Factors; Tritium; Uracil; Uridine | 1971 |
Dibutyryl adenosine cyclic 3':5'-monophosphate effects on goldfish behavior and brain RNA metabolism.
Topics: Animals; Base Sequence; Behavior, Animal; Biological Clocks; Brain; Butyrates; Centrifugation, Density Gradient; Cerebral Ventricles; Cyclic AMP; Cyprinidae; Cytosine Nucleotides; Electrophoresis, Paper; Orotic Acid; Posture; RNA; Tritium; Uracil Nucleotides; Uridine | 1971 |
Induction of bone resorption in tissue culture. Prolonged response after brief exposure to parathyroid hormone or 25-hydroxycholecalciferol.
Topics: Alkaloids; Animals; Bone Resorption; Calcitonin; Calcium; Calcium Isotopes; Cholecalciferol; Cyclic AMP; Cycloheximide; Dactinomycin; Female; Fetus; Magnesium; Orotic Acid; Parathyroid Hormone; Phosphates; Plicamycin; Prostaglandins; RNA; Theophylline; Time Factors; Tritium; Uridine; Vitamin A | 1972 |
Tumor cell sap factor stimulating orotate incorporation into nucleic acids in ascites hepatoma cells.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Carcinoma, Hepatocellular; Cytoplasm; Diphosphates; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Nucleic Acids; Orotic Acid; Pentosyltransferases; Rats; Ribose; Thymidine; Tritium; Uridine | 1972 |
Action of miracil D and related compounds on DNA and RNA synthesis in regenerating liver and hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; DNA; Hepatectomy; Liver Neoplasms; Liver Regeneration; Lucanthone; Male; Neoplasms, Experimental; Orotic Acid; Rats; RNA; Thymidine; Time Factors; Tritium; Uridine | 1972 |
Nucleic acid and polyamine synthesis in the rat during short-term protein deficiency: responsiveness of the liver to partial hepatectomy.
Topics: Animal Nutritional Physiological Phenomena; Animals; Bone Marrow; Carbon Radioisotopes; Carboxy-Lyases; Dietary Proteins; DNA; Female; Hepatectomy; Liver; Liver Regeneration; Organ Size; Ornithine; Orotic Acid; Phosphotransferases; Polyamines; Protein Deficiency; Rats; RNA; Thymidine Kinase; Time Factors; Tritium; Uridine | 1974 |
The effects of bases and nucleosides on the intracellular contents of nucleotides and 5-phosphoribosyl 1-pyrophosphate in Escherichia coli.
Topics: Adenine; Adenine Nucleotides; Adenosine; Carbon Radioisotopes; Cytosine Nucleotides; Escherichia coli; Guanine; Guanine Nucleotides; Guanosine; Hypoxanthines; Inosine; Inosine Nucleotides; Kinetics; Organophosphorus Compounds; Orotic Acid; Pentosephosphates; Phosphoric Acids; Ribonucleosides; Ribonucleotides; Time Factors; Uracil; Uracil Nucleotides; Uridine | 1974 |
Evidence from the control of pyrimidine biosynthesis in tissue minces by purines.
Topics: Adenosine; Animals; Aspartic Acid; Bicarbonates; Carbamates; Carbon Radioisotopes; Chickens; Guanosine; In Vitro Techniques; Male; Mammary Glands, Animal; Organ Specificity; Organophosphorus Compounds; Orotic Acid; Oviducts; Phosphotransferases; Rats; Time Factors; Uridine | 1974 |
Effect of uridine on de novo pyrimidine biosynthesis in rat hepatoma cells in culture.
Topics: Amidohydrolases; Animals; Aspartate Carbamoyltransferase; Carbamates; Carbon Dioxide; Carbon Radioisotopes; Carboxy-Lyases; Carcinoma, Hepatocellular; Clone Cells; Cycloheximide; Dactinomycin; DNA, Neoplasm; Glutamine; Kinetics; Liver Neoplasms; Neoplasms, Experimental; Orotic Acid; Pentosyltransferases; Phosphotransferases; Pyrimidine Nucleotides; Rats; Ribonucleotides; RNA, Neoplasm; Uridine | 1974 |
The thiolation, methylation, and formation of pseudouridine and dihydrouridine in tRNA of regenerating rat liver, human phytohemagglutinin stimulated lymphocytes, and Novikoff ascites cells.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cells, Cultured; Cysteine; Electrophoresis, Polyacrylamide Gel; Lectins; Liver; Liver Neoplasms; Liver Regeneration; Lymphocytes; Male; Methionine; Methylation; Neoplasms, Experimental; Nucleosides; Orotic Acid; RNA, Neoplasm; RNA, Transfer; Sulfur Radioisotopes; Transcription, Genetic; Uridine | 1972 |
Inhibitory effects of 2-thiouracil and 2-thiouracil metabolites on enzymes involved in pyrimidine nucleotide biosynthesis.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; In Vitro Techniques; Kinetics; Mice; Nucleotidyltransferases; Orotic Acid; Pentosyltransferases; Phosphotransferases; Proteins; Pyrimidines; Rats; Thiouracil; Thymidine; Thymine; Uracil; Uracil Nucleotides; Uridine | 1974 |
Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Fluorouracil; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Liver Neoplasms; Liver Regeneration; Male; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; Phosphates; Rats; RNA, Neoplasm; Schistosomicides; Thioxanthenes; Thymidine; Time Factors; Transplantation, Homologous; Tritium; Uracil; Uridine | 1974 |
[Enzyme induction and nucleic acid metabolism under the influence of organ-specific nitrosamines].
Topics: Animals; Carbon Isotopes; Carcinogens; Cortisone; Depression, Chemical; Enzyme Induction; Liver; Liver Glycogen; Nitrosamines; Nitroso Compounds; Organ Specificity; Orotic Acid; Rats; RNA; Sarcosine; Tritium; Tryptophan Oxygenase; Tyrosine Transaminase; Uridine | 1968 |
Under-replication of ribosomal cistrons in polytene chromosomes of Rhynchosciara.
Topics: Adipose Tissue; Animals; Centrifugation, Density Gradient; Chromosomes; DNA Replication; Female; Genes; Insecta; Larva; Male; Metamorphosis, Biological; Nucleic Acid Hybridization; Organ Specificity; Orotic Acid; Ovary; RNA, Ribosomal; Salivary Glands; Species Specificity; Time Factors; Tritium; Uridine | 1974 |
Studies on the form and synthesis of messenger ribonucleic acid in the rat ventral prostate gland, including its tissue-specific stimulation by androgens.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Krebs 2; Castration; Cell Fractionation; Centrifugation, Density Gradient; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Injections, Intraperitoneal; Male; Organ Specificity; Orotic Acid; Polyribosomes; Prostate; Protein Biosynthesis; Rats; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; Sodium Dodecyl Sulfate; Sulfur Radioisotopes; Testosterone; Tritium; Uridine | 1974 |
Precursors for RNA synthesis and their metabolism in developing rat brain.
Topics: Aging; Animals; Brain; Cell Fractionation; Cell Nucleus; Chromatography, Thin Layer; Female; Guanine Nucleotides; Guanosine; Male; Microsomes; Neurons; Orotic Acid; Pyrimidine Nucleotides; Rats; RNA; Tritium; Uridine | 1974 |
Isolation and partial characterization of regulatory mutants of the pyrimidine pathway in Salmonella typhimurium.
Topics: Aspartic Acid; Centrifugation, Density Gradient; Chromosome Mapping; Culture Media; Cytosine Nucleotides; Drug Resistance, Microbial; Feedback; Fluorine; Fluorouracil; Genetics, Microbial; Mutation; Nucleotides; Orotic Acid; Oxidoreductases; Phosphorus; Phosphorus Isotopes; Pyrimidines; Salmonella typhimurium; Transduction, Genetic; Transferases; Uridine | 1972 |
Metabolic transformations of 5-azauracil and 5-azaorotic acid in mouse liver and Escherichia coli. Effect on the synthesis of pyrimidines.
Topics: Aza Compounds; Biotransformation; Carbon Isotopes; Carboxy-Lyases; Cell-Free System; Escherichia coli; Liver; Orotic Acid; Pentosyltransferases; Pyrimidines; RNA; Triazines; Uracil; Uridine | 1972 |
Autoradiographic localization of new RNA synthesis in hypertrophying skeletal muscle.
Topics: Animals; Autoradiography; Cell Fractionation; Connective Tissue; Dactinomycin; Fibroblasts; Hypertrophy; Macrophages; Microscopy, Electron; Microscopy, Phase-Contrast; Muscles; Orotic Acid; Rats; RNA; Time Factors; Tissue Extracts; Tritium; Uridine | 1973 |
Changes in the incorporation of different RNA precursors into the maternal liver during pregnancy.
Topics: Animals; Cell Nucleolus; Cell Nucleus; Cytidine; DNA-Directed RNA Polymerases; Female; Kinetics; Liver; Orotic Acid; Postpartum Period; Pregnancy; Pregnancy, Animal; Rats; RNA; Time Factors; Tritium; Uridine | 1973 |
[Comparative rate of utilization of uridine and orotic acid by human and rat bone marrow cells in short term cultures].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cells, Cultured; DNA; Male; Orotic Acid; Pyrimidine Nucleotides; Rats; RNA; Uridine | 1972 |
Some effects of aflatoxin B 1 , on RNA synthesis in rat and mouse liver.
Topics: Aflatoxins; Animals; Carbon Isotopes; Cell Nucleus; Dimethyl Sulfoxide; DNA-Directed RNA Polymerases; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Orotic Acid; Rats; RNA; Species Specificity; Tritium; Uridine | 1972 |
Amphibian ribosomal ribonucleic acids.
Topics: Amphibians; Animals; Carbon Isotopes; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Female; Kidney; Liver; Methionine; Molecular Conformation; Molecular Weight; Orotic Acid; Ovary; RNA, Ribosomal; Species Specificity; Transcription, Genetic; Tritium; Triturus; Uridine; Xenopus | 1972 |
Nature of some components of epididymis and ductus deferens secretion in mouse.
Topics: Animals; Epididymis; Histocytochemistry; Male; Mice; Mice, Inbred C57BL; Orotic Acid; Ribonucleases; RNA; Spectrum Analysis; Tritium; Uridine; Vas Deferens | 1972 |
[Mechanism of action of ftorafur, a new antineoplastic agent].
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Formates; Hot Temperature; In Vitro Techniques; Leukemia, Experimental; Mice; Neoplasm Transplantation; Orotic Acid; Pentosyltransferases; RNA, Neoplasm; Sarcoma 37; Spectrum Analysis; Uracil; Uridine | 1972 |
Biosynthesis of pyrimidine nucleotides in mouse salivary glands stimulated with isoproterenol.
Topics: Animals; Aspartate Carbamoyltransferase; Azauridine; Carbamates; Carbon Dioxide; Carbon Isotopes; DNA; Female; Glutamine; Hydrogen-Ion Concentration; Isoproterenol; Mice; Mitosis; Orotic Acid; Phosphotransferases; Pyrimidine Nucleotides; RNA; Solubility; Submandibular Gland; Thymidine; Time Factors; Tritium; Uridine | 1973 |
The effect of calcium on labeling of nucleic acids with radioactive precursors in heart tissue slices.
Topics: Animals; Calcium; Chromatography, Thin Layer; Culture Media; Culture Techniques; Cytidine; Dactinomycin; DNA; Male; Myocardium; Orotic Acid; Perfusion; Pyrimidine Nucleotides; Rats; RNA; Stimulation, Chemical; Thymidine; Time Factors; Tritium; Uracil; Uracil Nucleotides; Uridine | 1973 |
Early effect of testosterone in the incorporation of uridine into RNA of mouse kidney and seminal vesicles.
Topics: Animals; Castration; Cytidine; Kidney; Male; Mice; Orotic Acid; RNA; Seminal Vesicles; Testosterone; Time Factors; Tritium; Uridine | 1973 |
Biochemical changes in mouse liver after palmitoyl-ethanolamide (PEA) administration.
Topics: Animals; Carbon Isotopes; DNA; Ethanolamines; Glucuronidase; Hydrolysis; In Vitro Techniques; Liver; Male; Mice; Microsomes, Liver; Mitochondria, Liver; Orotic Acid; Palmitic Acids; Phosphorus Isotopes; Phosphorylase Kinase; Ribonucleases; Ribosomes; RNA; Thymidine; Tryptophan Oxygenase; Uridine | 1973 |
DEAE paper chromatography to separate intermediates of the pyrimidine biosynthetic pathway and to assay asparatate transcarbamylase and dihydroorotase activities.
Topics: Amidohydrolases; Aspartate Carbamoyltransferase; Aspartic Acid; Autoradiography; Carbamates; Carbon Isotopes; Chlorella; Chlorophyta; Chromatography, DEAE-Cellulose; Chromatography, Paper; Kinetics; Methods; Nucleotides; Orotic Acid; Uridine | 1973 |
The synthesis of ribonucleic acid in vivo in the nuclei of rat brain fractionated by zonal centrifugation.
Topics: Adenosine; Animals; Brain; Carbon Isotopes; Cell Fractionation; Cell Nucleus; Centrifugation, Zonal; Kinetics; Male; Orotic Acid; Rats; RNA; Time Factors; Tritium; Uridine | 1973 |
Uptake of orotate and thymidine by normal and regenerating rat livers.
Topics: Aging; Animals; Biological Transport, Active; Body Weight; Chromatography, Thin Layer; Hepatectomy; Inulin; Kidney Cortex; Liver; Liver Regeneration; Muscles; Organ Size; Organ Specificity; Orotic Acid; Pancreas; Rats; Salivary Glands; Thymidine; Thymus Gland; Time Factors; Tritium; Uridine | 1973 |
Compartmentalization of uridine and uridine 5'-monophosphate in rat liver slices.
Topics: Animals; Carbon Isotopes; Cell Membrane; Cytoplasm; Female; Kinetics; Liver; Mathematics; Models, Biological; Models, Chemical; Orotic Acid; Perfusion; Rats; Tritium; Uracil; Uracil Nucleotides; Uridine | 1973 |
Abnormal RNA metabolism in male genital tract of tailless mouse (T-t).
Topics: Animals; Epididymis; Kinetics; Male; Mice; Mice, Inbred Strains; Orotic Acid; RNA; Tritium; Uridine | 1973 |
Urine orotic acid-orotidine levels in azaribine-treated patients with psoriasis.
Topics: Administration, Oral; Aza Compounds; Central Nervous System Diseases; Creatinine; Humans; Orotic Acid; Psoriasis; Ribonucleosides; Spectrophotometry; Uridine | 1973 |
Changes in ribonucleic acid metabolism associated with 3-methylcholanthrene-induced adult rat liver growth.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Kinetics; Liver; Male; Methylcholanthrene; Organ Size; Orotic Acid; Polysaccharides; Proteins; Rats; RNA; Subcellular Fractions; Tritium; Uracil Nucleotides; Uridine | 1973 |
Nucleic acid precursor synthesis by Plasmodium lophurae parasitizing chicken erythrocytes.
Topics: Adenine; Animals; Autoradiography; Carbon Radioisotopes; Chickens; Culture Media; DNA; Erythrocytes; Formates; Glycine; Malaria, Avian; Male; Orotic Acid; Plasmodium; Purine Nucleotides; Pyrimidine Nucleotides; RNA; Spectrophotometry; Thymidine; Tritium; Uracil; Uridine | 1973 |
Amphetamine and RNA and protein metabolism in rat brain.
Topics: Amphetamine; Animals; Body Temperature; Brain; Carbon Radioisotopes; Cell Nucleus; Cytoplasm; DNA; Leucine; Liver; Male; Nerve Tissue Proteins; Occipital Lobe; Orotic Acid; Rats; RNA; Uridine | 1973 |
Prevention of the hepatotoxic effects of D-galactosamine by D-galactose.
Topics: Animals; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Chromatography, Ion Exchange; Galactosamine; Galactose; In Vitro Techniques; Liver; Male; Mice; Nucleotides; Orotic Acid; Tritium; Uridine; Valine | 1973 |
Hereditary orotic aciduria: types I and II.
Topics: Australia; Clinical Enzyme Tests; Female; Heterozygote; Humans; Male; Orotic Acid; Pedigree; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Uracil Nucleotides; Uridine | 1973 |
Metabolism of RNA and pyrimidine nucleotides in the uterus during the early decidual cell reaction.
Topics: Animals; Carbon Radioisotopes; Castration; Cytidine; Cytosine Nucleotides; Decidua; DNA; Estradiol; Female; Mice; Organ Size; Orotic Acid; Pregnancy; Progesterone; Pyrimidine Nucleotides; RNA; Sesame Oil; Time Factors; Tritium; Uracil Nucleotides; Uridine; Uterus | 1973 |
Detection of the feedback control of pyrimidine biosynthesis in slices of several rat tissues.
Topics: Animals; Aspartic Acid; Bicarbonates; Carbamates; Carbon Radioisotopes; Depression, Chemical; Feedback; Female; Kidney; Liver; Mammary Glands, Animal; Organophosphorus Compounds; Orotic Acid; Pyrimidines; Rats; Spleen; Uridine | 1973 |
Qualitative and quantitative aspects of the biosynthesis of ribonucleic acid and of protein in the liver and the lung of the Syrian golden hamster.
Topics: Animals; Aspartate Carbamoyltransferase; Carbon Radioisotopes; Carboxy-Lyases; Cricetinae; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Kinetics; Leucine; Liver; Lung; Orotic Acid; Pentosyltransferases; Phosphotransferases; Protein Biosynthesis; Pyrimidine Nucleotides; Pyrimidines; Ribonucleotides; RNA; Uridine | 1973 |
The effects of diethylnitrosamine on ribonucleic acid and protein synthesis in the liver and lung of the Syrian golden hamster.
Topics: Animals; Carbon Radioisotopes; Cricetinae; DNA; Injections, Subcutaneous; Leucine; Liver; Lung; Male; Methylcholanthrene; Mixed Function Oxygenases; Nitrosamines; Orotic Acid; Phosphotransferases; Protein Biosynthesis; RNA; Thymidine; Uridine | 1973 |
Mechanism of turnover of rapidly labeled RNA in rat liver nuclei.
Topics: Adenine; Animals; Carbon Radioisotopes; Cell Nucleus; Cytoplasm; Female; In Vitro Techniques; Liver; Methods; Orotic Acid; Phosphorus Radioisotopes; Phosphotransferases; Rats; RNA; Tritium; Uracil Nucleotides; Uridine | 1973 |
Selective uridine triphosphate deficiency induced by D-galactosamine in liver and reversed by pyrimidine nucleotide precursors. Effect on ribonucleic acid synthesis.
Topics: Adenosine Triphosphate; Animals; Carbamates; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Paper; Cytosine Nucleotides; Female; Galactosamine; Guanosine; Guanosine Triphosphate; Kinetics; Liver; Organophosphorus Compounds; Orotic Acid; Pyrimidine Nucleotides; Rats; RNA; Succinates; Time Factors; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1974 |
Neonatal undernutrition and RNA synthesis in developing rat brain.
Topics: Aging; Animals; Body Weight; Brain; Cell Nucleus; Chromatography, Thin Layer; Deficiency Diseases; DNA; DNA-Directed RNA Polymerases; Female; Food Deprivation; Male; Microsomes; Nucleotides; Organ Size; Orotic Acid; Rats; Rats, Inbred Strains; RNA; Tritium; Uracil Nucleotides; Uridine | 1974 |
[Relation of RNA and protein synthesis in the brain to the state of the cholino- and adrenoreceptors].
Topics: Adenine; Amphetamine; Animals; Arecoline; Benactyzine; Brain; Carbon Radioisotopes; Female; Glycine; Haloperidol; Nerve Tissue Proteins; Orotic Acid; Rats; Receptors, Drug; RNA; Tritium; Uridine | 1974 |
The inhibition of rat liver nuclear ribonucleic acid synthesis by galactosamine and its reversal by uridine.
Topics: Adenine; Animals; Cell Nucleus; Chromatography, Gel; Depression, Chemical; DNA; Dose-Response Relationship, Drug; Female; Galactosamine; In Vitro Techniques; Liver; Orotic Acid; Rats; RNA; Solubility; Stimulation, Chemical; Time Factors; Tritium; Uracil Nucleotides; Uridine | 1974 |
Pyrimidine utilization by exponentially growing and starved cells of Rhodotorula gracilis.
Topics: Carbon Radioisotopes; Culture Media; DNA; Lipids; Mitosporic Fungi; Orotic Acid; Polysaccharides; Proteins; Pyrimidines; RNA; Time Factors; Tritium; Uridine | 1974 |
[Influence of borate and germanate on the biosynthesis of RNA].
Topics: Borates; Carbon Isotopes; Cell Nucleus; Escherichia coli; Germanium; Kinetics; Liver; Orotic Acid; Polynucleotides; RNA; RNA Nucleotidyltransferases; Stimulation, Chemical; Tritium; Uracil Nucleotides; Uridine | 1968 |
Detection of an organ-specific population of RNA in the salmon brain.
Topics: Acetates; Aluminum Silicates; Animals; Brain; Centrifugation, Density Gradient; Deoxyribonucleases; DNA; Escherichia coli; Heart; Liver; Orotic Acid; Quinolines; Ribonucleases; RNA; Salmonidae; Sucrose; Tritium; Uridine | 1969 |
Stimulation of RNA synthesis in the salivary gland by isoproterenol.
Topics: Animals; Female; Isoproterenol; Orotic Acid; Rats; Rats, Inbred Strains; RNA; Salivary Glands; Uridine | 1966 |
DNA, RNA , and protein synthesis in erythrocytic forms of Plasmodium knowlesi.
Topics: Adenine; Animals; Antimalarials; Carbon Isotopes; Culture Media; DNA; Erythrocytes; Glycine; Haplorhini; Isoleucine; Methionine; Orotic Acid; Phenylalanine; Plasmodium; Protein Biosynthesis; RNA; Sulfur Isotopes; Thymidine; Tritium; Tryptophan; Uracil; Uridine | 1968 |
[Presence of a double chain ribonucleic acid in animal cells].
Topics: Animals; Centrifugation, Density Gradient; Chick Embryo; Culture Techniques; Liver; Orotic Acid; Rats; RNA; RNA, Neoplasm; Tritium; Uridine; Virus Diseases | 1968 |
[Passage of radioactive substances between a labelled graft and its unmarked host. Autoradiographic study of sea urchin embryo submitted to transplantation].
Topics: Alanine; Amino Acids; Animals; Autoradiography; Echinodermata; Embryo Transfer; Leucine; Lysine; Mosaicism; Nucleic Acids; Orotic Acid; Transplantation, Homologous; Tritium; Uridine | 1969 |
Effect of chlorpromazine on cell wall biosynthesis and incorporation of orotic acid into nucleic acids in Bacillus megaterium.
Topics: Adenine; Bacillus megaterium; Bacterial Proteins; Carbon Isotopes; Cell Wall; Chlorpromazine; DNA, Bacterial; Formates; Lysine; Models, Biological; Nucleic Acids; Orotic Acid; Pimelic Acids; Promazine; RNA; RNA, Bacterial; Sulfoxides; Thymidine; Time Factors; Trifluoperazine; Uridine | 1971 |
Effect of nutritive state and precursor dose on the incorporation of orotic acid and uridine into kidney and liver of normal, castrated and, and androgen-treated mice.
Topics: Animals; Carbon Isotopes; Castration; Chromatography, Ion Exchange; Chromatography, Paper; Fasting; Kidney; Liver; Male; Mice; Mice, Inbred Strains; Orotic Acid; Pyrimidines; RNA; Testosterone; Time Factors; Tritium; Uridine | 1972 |
Effects of 17 beta-estradiol on the incorporation of pyrimidine nucleotide precursors into nucleotide pools and RNA in the mouse uterus.
Topics: Animals; Carbon Isotopes; Chromatography, Ion Exchange; Cytidine; Cytosine Nucleotides; DNA; Estradiol; Female; Mice; Nucleotides; Organ Size; Orotic Acid; RNA; Spectrophotometry; Time Factors; Tritium; Uracil Nucleotides; Uridine; Uterus | 1972 |
[Incorporation of uridine and of orotate into chloroplast ribosome RNA of Chlorella after treatment with antibiotics].
Topics: Chloramphenicol; Chlorella; Chlorophyta; Chloroplasts; Cycloheximide; Orotic Acid; Rifampin; RNA, Ribosomal; Time Factors; Uridine | 1972 |
Inhibition of thymidylic acid kinase by 5-substituted pyrimidines.
Topics: Aldehydes; Animals; Carcinoma, Ehrlich Tumor; Depression, Chemical; Dimethyl Sulfoxide; DNA, Neoplasm; Hepatectomy; In Vitro Techniques; Liver; Liver Regeneration; Male; Mice; Orotic Acid; Oxidative Phosphorylation; Potassium Chloride; Pyrimidines; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Thymidine Kinase; Thymine Nucleotides; Tritium; Uridine | 1972 |
Ribosomal RNA genes in salivary gland and ovary of Rhynchosclara angelae.
Topics: Animals; Centrifugation, Density Gradient; Diptera; DNA; DNA Replication; Female; Genes, Regulator; Haploidy; Heterochromatin; Larva; Nucleic Acid Hybridization; Orotic Acid; Ovary; RNA, Ribosomal; Salivary Glands; Tritium; Uridine | 1972 |
A comparative study of in vivo RNA and protein synthesis in rat liver and lung.
Topics: Amines; Animals; Carbon Isotopes; Carbon Tetrachloride; Cycloheximide; Dactinomycin; Ethionine; Female; Leucine; Liver; Lung; Male; Nickel; Nitroso Compounds; Orotic Acid; Protein Biosynthesis; Rats; RNA; Urethane; Uridine | 1972 |
Time course of the effect of AAF on mouse liver nucleic acid synthesis and its modification by inhibitors.
Topics: Acetates; Animals; Centrifugation, Density Gradient; Cycloheximide; Dactinomycin; DNA; Fluorenes; Hydroxyurea; Leucine; Liver; Male; Mice; Orotic Acid; Protein Biosynthesis; RNA; RNA Nucleotidyltransferases; RNA, Ribosomal; RNA, Transfer; Thymidine; Time Factors; Tritium; Uridine; Urinary Bladder | 1972 |
Control of pyrimidine biosynthesis in rat liver by feedback inhibition of aspartate carbamoyltransferase.
Topics: Animals; Aspartic Acid; Bicarbonates; Carbamates; Carbon Isotopes; Feedback; Kinetics; Liver; Orotic Acid; Phosphoric Acids; Pyrimidines; Rats; Transferases; Uridine | 1972 |
[Influence of 6-aza-uridine on facilitation of relearning by precursors of ribonucleic acid].
Topics: Animals; Avoidance Learning; Aza Compounds; Brain; Cerebral Ventricles; Conditioning, Psychological; Drug Antagonism; Injections, Spinal; Male; Orotic Acid; Rats; Rats, Inbred Strains; RNA; Uracil Nucleotides; Uridine | 1972 |
The in vivo biosynthesis of DNA, RNA, and proteins by mouse embryos after a teratogenic dose of cyclophosphamide.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Cyclophosphamide; DNA; Embryo, Mammalian; Female; Injections, Intraperitoneal; Leucine; Liver; Methods; Mice; Mice, Inbred Strains; Orotic Acid; Placenta; Pregnancy; Protein Biosynthesis; RNA; Thymidine; Time Factors; Uridine | 1972 |
Cell damage by trapping of biosynthetic intermediates. The role of uracil nucleotides in experimental hepatitis.
Topics: Alanine Transaminase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Hepatitis; Hexosamines; Liver; Orotic Acid; Oxidoreductases; Rats; Uracil; Uracil Nucleotides; Uridine | 1971 |
Glucocorticoid inhibition of precursor incorporation into nuclear RNA of P1798 lymphosarcoma.
Topics: Animals; Carbon Isotopes; Cell Biology; Cell Nucleus; Centrifugation, Density Gradient; Chromatography; Depression, Chemical; Fluorine; Hydrogen-Ion Concentration; In Vitro Techniques; Lymphoma, Non-Hodgkin; Mice; Mitochondria; Nucleosides; Nucleotides; Orotic Acid; Prednisolone; Pyrimidines; RNA, Neoplasm; RNA, Ribosomal; Solubility; Time Factors; Tritium; Uracil; Uridine | 1971 |
2,3-Dihydro-1H-imidazo(1,2-b)pyrazole: a new inhibitor of deoxyribonucleic acid synthesis.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Cytidine; Deoxyribonucleosides; Depression, Chemical; DNA; DNA Replication; Imidazoles; In Vitro Techniques; Kinetics; L Cells; Leucine; Macromolecular Substances; Mice; Orotic Acid; Protein Biosynthesis; Pyrazoles; Sarcoma 180; Thymidine; Uridine | 1971 |
RNA metabolism in rat intestinal mucosa of normal and vitamin A-deficient rats.
Topics: Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Chromatography; DNA; Intestinal Mucosa; Intestine, Small; Isotope Labeling; Leucine; Orotic Acid; Proteins; Rats; RNA; RNA, Transfer; Threonine; Tritium; Uracil Nucleotides; Uridine; Vitamin A Deficiency | 1971 |
Enzymes of nucleic acid metabolism in the brains of young and adult rats.
Topics: Animals; Brain; Carbon Isotopes; Carboxy-Lyases; Cytidine; Glucosyltransferases; Guanosine; Methionine; Methyltransferases; Orotic Acid; Phosphotransferases; Purines; Rats; RNA; RNA Nucleotidyltransferases; Tritium; Uracil Nucleotides; Uridine | 1971 |
Effect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblasts.
Topics: Allopurinol; Carbon Isotopes; Carbon Radioisotopes; Carboxy-Lyases; Cells, Cultured; Erythrocytes; Fibroblasts; Guanine Nucleotides; Humans; Hypoxanthines; Nucleic Acids; Orotic Acid; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Proteins; Pyrazoles; Pyrimidines; Ribonucleosides; Ribonucleotides; Ribose; Skin; Tritium; Uracil Nucleotides; Uridine; Xanthine Oxidase; Xanthines | 1971 |
Effect of benzene on rat liver polyribosomes.
Topics: Amino Acyl-tRNA Synthetases; Animals; Benzene; Centrifugation, Density Gradient; In Vitro Techniques; Liver; Macromolecular Substances; Male; Microsomes, Liver; Orotic Acid; Phenylalanine; Poly U; Polynucleotides; Polyribosomes; Protein Biosynthesis; Rats; Ribosomes; RNA; RNA, Ribosomal; Sucrose; Time Factors; Tritium; Uracil Nucleotides; Uridine | 1971 |
Inhibition of DNA synthesis in Ehrlich ascites cells by actinomycin D. II. The presynthetic block in the cell cycle.
Topics: Animals; Autoradiography; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Division; Dactinomycin; DNA, Neoplasm; In Vitro Techniques; Mice; Orotic Acid; RNA; RNA, Neoplasm; Thymidine; Thymidine Kinase; Tritium; Ultracentrifugation; Uridine | 1965 |
Ribonucleic acid biosynthesis in human leukocytes. Effects of phagocytosis on RNA metabolism.
Topics: Adult; Carbon Isotopes; Humans; Leukemia, Myeloid; Leukocytes; Male; Nucleotides; Orotic Acid; Phagocytosis; Polycythemia Vera; Primary Myelofibrosis; Pyrimidines; RNA; Sucrose; Tritium; Uridine | 1966 |
Pyrimidine metabolism in human leukocytes. I. Contribution of exogenous thymidine to DNA-thymine and its effect on thymine nucleotide synthesis in leukemic leukocytes.
Topics: Carbon Isotopes; Cytosine Nucleotides; DNA, Neoplasm; Guanine Nucleotides; Humans; In Vitro Techniques; Leukemia, Myeloid; Leukocytes; Nucleotides; Orotic Acid; Thymidine; Thymine; Tritium; Uridine | 1966 |
RNA metabolism in goldfish brain during acquisition of new behavioral patterns.
Topics: Animals; Behavior, Animal; Brain; Centrifugation, Density Gradient; Cyprinidae; Learning; Memory; Nucleosides; Orotic Acid; Potassium Chloride; Psychophysiology; RNA; Seizures; Swimming; Tritium; Uridine | 1970 |
Pyrimidine and purine bases and nucleosides in wheat plants.
Topics: Adenine; Carbon Isotopes; Chromatography; Cytosine; Nucleosides; Orotic Acid; Purines; Pyrimidines; Radioisotope Dilution Technique; Triticum; Uracil; Uridine | 1967 |
Hereditary orotic aciduria: long-term therapy with uridine and a trial of uracil.
Topics: Alanine; Anemia, Macrocytic; Child; Child, Preschool; Humans; Infant; Intellectual Disability; Male; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Uracil; Uridine | 1969 |
Hereditary orotic aciduria with normal growth and development.
Topics: Anemia; Bone Marrow Examination; Carboxy-Lyases; Child; Culture Techniques; Female; Humans; Leukopenia; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Transferases; Uridine | 1969 |
Pyrimidine synthesis in Neurospora crassa: gene-enzyme relationships.
Topics: Alleles; Amidohydrolases; Chromosome Mapping; Genetic Complementation Test; Genetics, Microbial; Molecular Biology; Mutation; Neurospora; Orotic Acid; Oxidoreductases; Pyrimidines; Transferases; Uridine | 1969 |
Pyrimidine synthesis in Neurospora crassa: regulation of enzyme activities.
Topics: Amidohydrolases; Enzyme Repression; Mutation; Neurospora; Orotic Acid; Oxidoreductases; Pyrimidines; Transferases; Uridine | 1969 |
Comparative in vivo studies of RNA synthesis in the fetal liver, placenta, and maternal liver.
Topics: Animals; Carbon Isotopes; Female; Fetus; Gestational Age; Liver; Orotic Acid; Placenta; Pregnancy; Rats; RNA; Uridine | 1969 |
Inhibition of thymidine kinase by cortisone.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cortisone; DNA; DNA Nucleotidyltransferases; Female; Glycine; Mice; Orotic Acid; Phosphotransferases; Thymidine; Thymidine Kinase; Tritium; Uridine | 1970 |
Biosynthesis of pyrimidines by various organs of the chick during embryogenesis.
Topics: Amidohydrolases; Animals; Aspartic Acid; Brain; Chick Embryo; DNA; Intestines; Liver; Myocardium; Orotic Acid; Phosphotransferases; Pyrimidines; Transferases; Uridine | 1970 |
Biochemical and pathological effects of methylazoxymethanol acetate, a potent carcinogen.
Topics: Animals; Azo Compounds; Carbon Isotopes; Carcinogens; DNA; Intestine, Small; Kidney; Leucine; Liver; Mice; Microscopy, Electron; Neoplasms, Experimental; Nucleosides; Orotic Acid; Phosphorus Isotopes; Protein Biosynthesis; Rats; RNA; Thymidine; Tritium; Uridine | 1970 |
Inhibitory effects of cortisol and antibiotics on substrate entry and ribonucleic acid synthesis in rat thymocytes in vitro.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Carbon Isotopes; Cell Nucleus; Centrifugation, Density Gradient; Dactinomycin; Glycine; Hydrocortisone; Male; Orotic Acid; Progesterone; Protein Biosynthesis; Puromycin; Rats; RNA; RNA Nucleotidyltransferases; Thymus Gland; Tritium; Uridine | 1970 |
Interrelations of diet-induced changes in hexosemonophosphate shunt dehydrogenases with RNA metabolism in rat liver slices.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carbon Isotopes; Dietary Carbohydrates; Dietary Proteins; Fasting; Glucose; Glucosephosphate Dehydrogenase; Liver; Male; Orotic Acid; Pentoses; Phosphogluconate Dehydrogenase; Rats; Ribose; RNA; Uridine | 1970 |
Pyrimidine nucleotide synthesis in the normal and hypertrophying rat heart. Relative importance of the de novo and "salvage" pathways.
Topics: Animals; Cardiomyopathies; In Vitro Techniques; Male; Myocardium; Nucleotides; Orotic Acid; Phosphotransferases; Pyrimidines; Rats; RNA; Time Factors; Transferases; Tritium; Uracil; Uracil Nucleotides; Uridine | 1970 |
Effect of dietary purine restriction, allupurinol, and oxipurinol on urinary excretion of ultraviolet-absorbing compounds.
Topics: Adenine; Allopurinol; Chromatography, Ion Exchange; Diet; Humans; Hypoxanthines; Orotic Acid; Purines; Pyrimidines; Spectrophotometry; Ultraviolet Rays; Uric Acid; Uridine; Xanthine Oxidase | 1970 |
The action of some orotic acid analogues on the in vitro incorporation of 14C-orotate into pyrimidine nucleotides.
Topics: Carbon Isotopes; Hydrazines; Liver; Nucleosides; Nucleotides; Orotic Acid; Picolinic Acids; Uridine | 1970 |
Effects of cortisone on orotic acid transport and RNA synthesis in rat liver.
Topics: Adrenal Glands; Adrenalectomy; Animals; Biological Transport; Carbon Isotopes; Cortisone; Guanine; Liver; Male; Orotic Acid; Rats; RNA; Stimulation, Chemical; Tritium; Tryptophan Oxygenase; Uracil Nucleotides; Uridine | 1970 |
[Utilization of pyrimidine precursors in the tumor and liver of mice with Ehrlich ascites carcinoma].
Topics: Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cytosine; DNA; DNA, Neoplasm; Liver; Male; Melanoma; Mice; Neoplasms, Experimental; Nucleotides; Orotic Acid; Pyrimidines; RNA; RNA, Neoplasm; Sarcoma 180; Sodium; Thymidine; Thymine; Tritium; Uridine | 1970 |
[Nature of RNA synthesized in liver cells during cortisone treatment].
Topics: Animals; Carbon Isotopes; Cell Nucleus; Cortisone; Cytoplasm; Liver; Male; Nucleotides; Orotic Acid; Phosphorus Isotopes; Rats; RNA; Tritium; Uridine | 1970 |
Hereditary orotic aciduria.
Topics: Anemia, Macrocytic; Child, Preschool; Female; Growth Disorders; Humans; Infant; Intellectual Disability; Male; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Uridine | 1970 |
Biosynthesis of deoxyribonucleotides in Ochromonas malhamensis.
Topics: Animals; Carbon Isotopes; DNA; Eukaryota; Methods; Nucleosides; Nucleotides; Orotic Acid; Purines; Pyrimidines; RNA; Uridine | 1971 |
Molecular conformation of orotidine, a naturally occurring nucleoside, in the syn conformation in aqueous solution.
Topics: Molecular Biology; Nucleosides; Orotic Acid; Spectrum Analysis; Uric Acid; Uridine; Water | 1971 |
Paper disc estimation of radioactive RNA: studies on the presence and elimination of metabolically generated artifacts from labeled purine and pyrimidine precursors.
Topics: Animals; Carbon Isotopes; Filtration; Guanine; Leucine; Liver; Male; Methods; Orotic Acid; Paper; Radiometry; Rats; RNA; Trichloroacetic Acid; Tritium; Uridine | 1971 |
Studies on the origin of pyrimidines for biosynthesis of neural RNA in the rat.
Topics: Animals; Brain; Brain Stem; Carbon Isotopes; Cerebellum; Cerebral Cortex; Female; In Vitro Techniques; Kidney; Liver; Male; Orotic Acid; Pyrimidines; Rats; RNA; Trichloroacetic Acid; Tritium; Uridine | 1971 |
Characterization and rapid labelling of pituitary RNA.
Topics: Animals; Brain; Carbon Isotopes; Centrifugation, Density Gradient; Female; Male; Nucleosides; Organ Size; Orotic Acid; Pituitary Gland; Rats; Ribosomes; RNA; Tritium; Uridine | 1968 |
The effect of parathyroid hormone in vivo on the labeling of nuclear ribonucleic acid from the intestinal mucosa and liver of vitamin D-deficient and normal chicks.
Topics: Animals; Carbon Isotopes; Chickens; Diet; Intestinal Mucosa; Liver; Male; Orotic Acid; Parathyroid Hormone; RNA; Stimulation, Chemical; Tritium; Uridine; Vitamin D | 1968 |
Nucleotide metabolism in rat brain.
Topics: Adenine; Animals; Aspartic Acid; Carbon Isotopes; Cerebral Cortex; Chromatography, Paper; DNA; Glucosyltransferases; Glycine; Guanine; Hypoxanthines; In Vitro Techniques; Nerve Tissue Proteins; Nucleosides; Nucleotides; Orotic Acid; Oxidoreductases; Phosphotransferases; Rats; RNA; Uridine; Xanthine Oxidase; Xanthines | 1968 |
Pyrimidine nucleoside metabolism in mammalian cells: an in vitro comparison of two rodent species.
Topics: Animals; Autoradiography; Carbon Isotopes; Chromatography, Paper; Cricetinae; Culture Techniques; Deoxyuridine; DNA; Liver; Nucleosides; Orotic Acid; Sciuridae; Spleen; Thymidine; Thymidine Kinase; Tritium; Uridine | 1968 |
Biochemical effects of formycin B on Xanthomonas oryzae.
Topics: Antibiotics, Antineoplastic; Bacterial Proteins; Carbon Isotopes; Chromatography, Paper; Depression, Chemical; Electrophoresis; Formates; Leucine; Nucleosides; Nucleotides; Orotic Acid; Phosphoric Acids; Phosphotransferases; Thymidine; Tritium; Uridine; Xanthomonas | 1968 |
Some aspects of the role of folic acid in nucleic acid synthesis in a neoplastic C3H mouse cell strain.
Topics: Animals; Carbon Isotopes; Cell Transformation, Neoplastic; Culture Techniques; DNA, Neoplasm; Folic Acid; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; RNA, Neoplasm; Thymidine; Uridine | 1968 |
Hereditary orotic aciduria. I. A new case with family studies.
Topics: Adult; Anemia, Macrocytic; Carboxy-Lyases; Chromosome Aberrations; Chromosome Disorders; Clinical Enzyme Tests; Erythrocytes; Genes, Recessive; Glucosyltransferases; Growth; Heterozygote; Humans; Infant; Liver; Metabolism, Inborn Errors; Orotic Acid; Pedigree; Pyrimidines; Uracil Nucleotides; Uridine | 1968 |
Hybridizable ribonucleic acid of rat brain.
Topics: Animals; Animals, Newborn; Brain; Carbon Isotopes; Cell Nucleus; Cytoplasm; DNA; Liver; Orotic Acid; Phosphates; Phosphorus Isotopes; Rats; RNA, Messenger; Tritium; Uridine | 1968 |
Effects of 2-tiouracil and related compounds on pyrimidine metabolism.
Topics: Animals; Carbon Isotopes; Kinetics; Liver; Male; Nucleotides; Orotic Acid; Pyrimidines; Rats; RNA; Thiouracil; Thiourea; Transferases; Uracil; Uridine | 1968 |
Influence of cycloheximide (Actidione) upon pyrimidine nucleotide metabolism and rna synthesis in cocklebur leaf discs.
Topics: Carbon Dioxide; Carbon Isotopes; Chromatography, Paper; Cycloheximide; Cytosine Nucleotides; Depression, Chemical; Nucleosides; Orotic Acid; Plants; RNA; Uracil Nucleotides; Uridine | 1968 |
Placental transfer of orotic acid, uridine, and UMP. I. Comparison of acid-soluble and acid-insoluble counts.
Topics: Animals; Carbon Isotopes; Female; Fetus; Gestational Age; Liver; Maternal-Fetal Exchange; Orotic Acid; Placenta; Pregnancy; Rats; RNA; Solubility; Uracil Nucleotides; Uridine | 1968 |
Ribosomal subunits of Landschütz ascites cells during changes in polysome distribution.
Topics: Amino Acids; Animals; Ascitic Fluid; Carbon Isotopes; Centrifugation, Density Gradient; Culture Media; Culture Techniques; Dactinomycin; Female; Liver; Male; Mice; Neoplasms, Experimental; Orotic Acid; Peritoneum; Rats; Ribosomes; Surface-Active Agents; Tritium; Ultracentrifugation; Uridine | 1968 |
Pyrimidine synthesis in tissue culture.
Topics: Animals; Aspartic Acid; Bicarbonates; Brain; Carbon Isotopes; Cerebellum; Chromatography, Thin Layer; Citrulline; Culture Techniques; Ligases; Liver; Orotic Acid; Pyrimidines; Rats; RNA; Sodium; Spectrum Analysis; Triazines; Tritium; Uridine | 1968 |
Transplacental passage of nucleotides, nucleosides, and bases.
Topics: Alkalies; Animals; Carbon Isotopes; Colchicine; Female; Fetus; Fluorouracil; Injections, Intraperitoneal; Injections, Intravenous; Liver; Maternal-Fetal Exchange; Nucleosides; Nucleotides; Orotic Acid; Placenta; Pregnancy; Purines; Pyrimidines; Radiometry; Rats; RNA; Solubility; Thymidine; Time Factors; Uracil Nucleotides; Uridine | 1968 |
Analytical studies on brain polysomal RNA using polyacrylamide and agarose-polyacrylamide gel electrophoresis.
Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; Cerebral Cortex; Electrophoresis; Electrophoresis, Disc; Gels; Microsomes; Orotic Acid; Rats; RNA; Tritium; Uridine | 1969 |
In vitro incorporation of precursors of RNA into the digestive gland of normal and of schistosoma-infected Biomphalaria glabrata.
Topics: Animals; Digestive System; DNA; Nucleosides; Orotic Acid; Protein Biosynthesis; RNA; Schistosomiasis; Snails; Tritium; Uridine | 1969 |
Orotic aciduria in a girl with normal growth and development.
Topics: Anemia, Macrocytic; Child; Erythrocytes; Female; Hematuria; Humans; Metabolism, Inborn Errors; Orotic Acid; Pyrimidines; Uridine | 1969 |
Mechanism of growth inhibition by 5-fluorouracil. Reversal studies with pyrimidine metabolites in vitro.
Topics: Animals; Carcinoma, Ehrlich Tumor; Culture Techniques; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Mice; Nucleotides; Orotic Acid; RNA, Neoplasm; Thymidine; Uridine | 1969 |
Orotic aciduria. Differing enzyme patterns.
Topics: Abnormalities, Multiple; Anemia, Macrocytic; Carboxy-Lyases; Erythrocytes; Humans; Infant; Male; Metabolism, Inborn Errors; Orotic Acid; Pyrimidines; Transferases; Uridine | 1969 |
Turnover of nuclear and cytoplasmic ribonucleic acid at the onset of induced amphibian metamorphosis.
Topics: Animals; Anura; Carbon Isotopes; Cell Nucleus; In Vitro Techniques; Liver; Metamorphosis, Biological; Microsomes; Mitochondria; Orotic Acid; Ribosomes; RNA; RNA, Transfer; Subcellular Fractions; Triiodothyronine; Tritium; Uridine | 1965 |
The role of deoxyribose 5-phosphate aldolase in the synthesis of deoxyribonucleotide in mammalian cells.
Topics: Adenine; Aldehyde-Lyases; Animals; Aspartic Acid; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA; Glycine; In Vitro Techniques; Liver; Liver Regeneration; Mice; Nucleotides; Orotic Acid; Protein Biosynthesis; Rats; RNA; Subcellular Fractions; Threonine; Thymidine; Uridine | 1966 |
RNA synthesis in rat and mouse hepatic cells as studied with light and electron microscope radioautography.
Topics: Animals; Autoradiography; Cell Nucleus; Cytoplasm; Female; Hydrocortisone; Liver; Mice; Microscopy; Microscopy, Electron; Orotic Acid; Rats; RNA; Tritium; Uridine | 1966 |
Relationship between the metabolic effects and the pregnancy-interrupting property of 6-azauridine in mice.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Embryo, Mammalian; Female; Fetus; Mice; Orotic Acid; Oxidative Phosphorylation; Pregnancy; Pregnancy, Animal; Uridine | 1966 |
Studies on 5-aminouridine.
Topics: Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Chromatography, Ion Exchange; In Vitro Techniques; Mitochondria; Orotic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine | 1966 |
Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro.
Topics: Cell Differentiation; Enzyme Repression; Humans; In Vitro Techniques; Kinetics; Lectins; Lymphocytes; Nucleosides; Orotic Acid; Phosphotransferases; RNA; Tritium; Uridine | 1967 |
Megaloblastic anemia and orotic aciduria. A hereditary disorder of pyrimidine metabolism responsive to uridine.
Topics: Anemia, Macrocytic; Bone Marrow Examination; Growth; Humans; Infant; Intellectual Disability; Male; Orotic Acid; Prednisone; Purine-Pyrimidine Metabolism, Inborn Errors; Uridine | 1967 |
Effects of uracil mustard on DNA, RNA, and protein biosynthesis in tissues of A-J mice.
Topics: Alkylating Agents; Animals; Carbon Isotopes; Carcinogens; DNA; Female; Kidney; Leucine; Liver; Lung; Male; Mice; Orotic Acid; Protein Biosynthesis; RNA; Thymidine; Tritium; Uracil Mustard; Uridine | 1967 |
A reversible inhibitor of nucleic acid synthesis.
Topics: Animals; Benzimidazoles; Cattle; Chick Embryo; Culture Media; Culture Techniques; DNA; Fibroblasts; HeLa Cells; Kidney; L Cells; Lysine; Nucleosides; Orotic Acid; RNA; Thymidine; Tritium; Uridine | 1967 |
Increased conversion of uridine-5'-phosphate and uridine-5'-triphosphate to cytosine nucleotides by a liver fraction from colchicine-treated rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Carbon Isotopes; Colchicine; Cytosine Nucleotides; Dialysis; In Vitro Techniques; Liver; Male; Nucleosides; Orotic Acid; Phosphates; Proteins; Rats; RNA; Uracil; Uracil Nucleotides; Uridine | 1967 |
Epidermal growth factor. I. The stimulation of protein and ribonucleic acid synthesis in chick embryo epidermis.
Topics: Animals; Carbon Isotopes; Chick Embryo; Culture Techniques; Dactinomycin; Growth Substances; Lysine; Orotic Acid; Protein Biosynthesis; Proteins; Puromycin; RNA; Skin; Submandibular Gland; Thymidine; Uridine | 1967 |
Comparison of anabolism of 14C-labelled orotic acid, uracil and uridine in excised pea plants.
Topics: Carbon Isotopes; Chromatography; Nucleotides; Orotic Acid; Plants, Edible; Uracil; Uridine | 1967 |
Photodimerization of pyrimidine nucleic acid derivatives in aqueous solution and the effect of oxygen.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Light; Nucleic Acids; Nucleotides; Orotic Acid; Oxygen; Polymers; Pyrimidines; Solutions; Thymidine; Thymine; Uracil; Uridine | 1967 |
The role of RNA in the hormonal induction of tyrosine aminotransferase in mammalian cells in tissue culture.
Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; Culture Techniques; Dexamethasone; Enzyme Induction; Hydrocortisone; Male; Orotic Acid; Rats; RNA; Transaminases; Tritium; Tyrosine; Uridine | 1967 |
Synthesis and breakdown of rat liver RNA during the neonatal period.
Topics: Animals; Animals, Newborn; Carbon Isotopes; Cell Nucleus; Female; Liver; Microsomes; Nitrogen; Orotic Acid; Phosphorus Isotopes; Pregnancy; Proteins; Rats; Ribonucleases; RNA; RNA Nucleotidyltransferases; Uridine | 1967 |
[RNA synthesis in the perfused rat liver. Study of the incorporation of labeled precursors].
Topics: Animals; Blood; Carbon Isotopes; Liver; Orotic Acid; Perfusion; Rats; RNA; Uridine | 1967 |
Early effects of parathyroid hormone and thyrocalcitonin on bone in organ culture.
Topics: Animals; Biological Transport; Bone and Bones; Bone Resorption; Calcitonin; Calcium; Calcium Isotopes; Carbon Isotopes; Culture Techniques; Dactinomycin; Drug Antagonism; Female; Orotic Acid; Parathyroid Hormone; Pregnancy; Rats; RNA; Tritium; Uridine | 1967 |
Biosynthesis of RNA in slices of guinea pig cerebral cortex.
Topics: Adenine; Animals; Carbon Isotopes; Cerebral Cortex; Chromatography, Thin Layer; Dactinomycin; Electrophoresis; Guinea Pigs; In Vitro Techniques; Orotic Acid; Paper; Phosphorus Isotopes; RNA; Tritium; Uracil; Uracil Nucleotides; Uridine | 1967 |
Hydra viridis: transfer of metabolites between Hydra and symbiotic algae.
Topics: Animals; Chlorella; DNA; Hydra; Kinetics; Leucine; Orotic Acid; RNA; Symbiosis; Thymidine; Thymidine Kinase; Uridine | 1981 |
Adenosine- and deoxyadenosine-mediated altered pyrimidine metabolism in human adeosine deaminase-deficient lymphoblasts.
Topics: Adenosine; Adenosine Deaminase; Cell Division; Cell Line; Deoxyadenosines; Humans; Immunologic Deficiency Syndromes; In Vitro Techniques; Lymphocytes; Nucleoside Deaminases; Orotic Acid; Phosphoribosyl Pyrophosphate; Pyrimidines; Uridine | 1982 |
Biochemical basis for the differential sensitivity of human T- and B-lymphocyte lines to 5-fluorouracil.
Topics: B-Lymphocytes; Biotransformation; Cell Line; Fluorodeoxyuridylate; Fluorouracil; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; RNA; T-Lymphocytes; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase; Uridine Triphosphate | 1982 |
Radioautographic visualization of differences in the pattern of [3H]uridine and [3H]orotic acid incorporation into the RNA of migrating columnar cells in the rat small intestine.
Topics: Animals; Autoradiography; Fixatives; Intestinal Mucosa; Intestine, Small; Male; Microscopy, Electron; Orotic Acid; Rats; RNA; Uridine | 1984 |
Diagnostic and therapeutic approaches in pyrimidine 5'-nucleotidase deficiency.
Topics: 5'-Nucleotidase; Clinical Enzyme Tests; Cytidine; Erythrocytes; Humans; Kinetics; Nucleotidases; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Uridine | 1984 |
Influence of purines on pyrimidine metabolism in rat hepatocytes.
Topics: Animals; Carbon Radioisotopes; In Vitro Techniques; Kinetics; Liver; Orotic Acid; Purines; Pyrimidines; Rats; Uridine | 1984 |
Orotate uptake and metabolism by human erythrocytes.
Topics: Biological Transport; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Lymphocytes; Orotic Acid; Uridine | 1984 |
Urinary pyrimidine excretion in arginase deficiency.
Topics: Adolescent; Ammonia; Arginine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Hyperargininemia; Orotic Acid; Pseudouridine; Pyrimidines; Reference Values; Uracil; Uridine | 1981 |
Anabolic and catabolic pathways of pyrimidine metabolism in rat liver.
Topics: Animals; Liver; Orotic Acid; Pyrimidine Nucleotides; Rats; Uridine | 1981 |
De novo pyrimidine nucleotide synthesis in the preimplantation mouse embryo.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Blastocyst; Mice; Morula; Orotic Acid; Phosphonoacetic Acid; Pyrimidine Nucleotides; Uridine | 1981 |
Changes in the levels and the rate of synthesis of transfer RNA in tissues of mice of different ages.
Topics: Aging; Animals; Female; Kidney; Liver; Mice; Mice, Inbred C57BL; Muscles; Myocardium; Orotic Acid; RNA, Transfer; Uridine | 1981 |
Conditions affecting the colorimetry of orotic acid and orotidine in urine.
Topics: Adult; Age Factors; Child; Child, Preschool; Colorimetry; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Male; Orotic Acid; Uridine | 1980 |
Orotic acid-induced metabolic changes in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Female; Lipid Metabolism; Liver; Nucleotides; Organ Size; Orotic Acid; Purines; Pyrimidines; Rats; Uridine | 1980 |
Free pyrimidine nucleotide pool of Ehrlich ascites-tumour cells. Characteristics related to quantitative studies of RNA metabolism.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cell Line; Half-Life; Kinetics; Mice; Models, Biological; Orotic Acid; Pyrimidine Nucleotides; RNA, Neoplasm; Uridine | 1980 |
Free pyrimidine nucleotide pool of Ehrlich ascites-tumour cells. Compartmentation with respect to the synthesis of heterogeneous nuclear RNA and precursors to ribosomal RNA.
Topics: Animals; Base Composition; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cell Compartmentation; Cell Line; Kinetics; Mice; Models, Biological; Orotic Acid; Pyrimidine Nucleotides; RNA, Heterogeneous Nuclear; RNA, Ribosomal; Uridine | 1980 |
Non-specific incorporation of nucleic acid precursors in Blastomyces dermatitidis and Histoplasma capsulatum.
Topics: Animals; Blastomyces; DNA, Fungal; Fungal Proteins; Histoplasma; Nucleic Acid Precursors; Orotic Acid; RNA, Fungal; Thymidine; Thymine Nucleotides; Uridine | 1980 |
An in vivo 31P magnetic resonance spectroscopy study of uridine excess in rats fed orotic acid.
Topics: Animals; Diet; Female; Liver; Magnetic Resonance Spectroscopy; Microscopy, Electron; Muscles; Orotic Acid; Phosphorus; Rats; Rats, Sprague-Dawley; Skin; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars; Uridine Triphosphate | 1995 |
The allopurinol loading test in detecting obligate heterozygotes for OCT deficiency.
Topics: Adolescent; Adult; Allopurinol; Chromatography, High Pressure Liquid; Female; Genetic Carrier Screening; Humans; Middle Aged; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Uridine | 1994 |
The allopurinol loading test for identification of carriers for ornithine carbamoyl transferase deficiency: studies in a healthy control population and females at risk.
Topics: Adolescent; Adult; Allopurinol; Child; Female; Heterozygote; Humans; Middle Aged; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Predictive Value of Tests; Risk; Spectrophotometry, Ultraviolet; Uridine | 1994 |
Efficiency of hemodialysis of pyrimidine compounds in patients with chronic renal failure.
Topics: Adult; Aged; Allopurinol; Creatinine; Female; Half-Life; Humans; Kidney Failure, Chronic; Male; Middle Aged; Orotic Acid; Pseudouridine; Pyrimidines; Renal Dialysis; Uric Acid; Uridine | 1993 |
Antagonistic effect of nucleic acid precursors on the anticoccidial activity of 6-azauracil.
Topics: Adenine; Adenosine; Animals; Chickens; Coccidiosis; Coccidiostats; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Eimeria; Food, Fortified; Male; Nucleic Acid Precursors; Orotic Acid; Poultry Diseases; Uracil; Uridine | 1996 |
Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families.
Topics: Adult; Animals; Base Sequence; Cell Line; Cell Line, Transformed; Child, Preschool; Cloning, Molecular; DNA; Escherichia coli; Exons; Female; Genes, Bacterial; Humans; Introns; Japan; Male; Molecular Sequence Data; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Point Mutation; Polymorphism, Genetic; Recombinant Proteins; Spodoptera; Uridine | 1997 |
Quick cancer test developed.
Topics: Allopurinol; Antimetabolites; Biomarkers, Tumor; DNA; Humans; Neoplasms; Orotic Acid; Pyrimidines; Uridine | 1998 |
Mechanism of cardioprotective effect of orotic acid.
Topics: Adenine Nucleotides; Animals; Heart; Hypoxia; In Vitro Techniques; Liver; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Myocardium; Orotic Acid; Oxygen Consumption; Purines; Pyrimidines; Rats; Rats, Sprague-Dawley; Time Factors; Uridine | 1998 |
The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease.
Topics: Allopurinol; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Metabolic Diseases; Mitochondria; Muscles; Orotic Acid; Predictive Value of Tests; Sensitivity and Specificity; Urea; Uridine | 1999 |
Influence of dose and age on the response of the allopurinol test for ornithine carbamoyltransferase deficiency in control infants.
Topics: Adolescent; Adult; Age Factors; Allopurinol; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Male; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Uridine | 2000 |
Successful living-donor liver transplantation from an asymptomatic carrier mother in ornithine transcarbamylase deficiency.
Topics: Adult; Amino Acids; Child; Female; Heterozygote; Humans; Liver Transplantation; Living Donors; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Treatment Outcome; Uridine | 2001 |
[Characterization and transformation of anti-FOA strain of Aspergillus awamori].
Topics: Aspergillus; Culture Media; Drug Resistance, Microbial; Fungal Proteins; Mutation; Orotic Acid; Spores, Fungal; Transformation, Genetic; Ultraviolet Rays; Uridine | 2000 |
Non-utilization of radioactive iodinated uracil, uridine, and orotic acid by animal tissues in vivo.
Topics: Neoplasms; Orotic Acid; Uracil; Uridine | 1953 |
Spectrophotometric studies of nucleic acid derivatives and related compounds as a function of pH. IV. On the structure of orotidine. A study of N-methylated orotic acids.
Topics: Nucleic Acids; Nucleotides; Orotic Acid; Spectrophotometry; Uridine | 1957 |
Conversion of uracil and orotate to uridine 5'-phosphate by enzymes in lactobacilli.
Topics: Lactobacillus; Nucleotides; Orotic Acid; Phosphates; Uracil; Uracil Nucleotides; Uridine | 1957 |
Elimination by the urine of orotic acid and orotidine in man after application of 6-azauracil.
Topics: Biological Transport; Body Fluids; Humans; Male; Nucleosides; Nucleotides; Orotic Acid; Uracil; Uridine | 1960 |
INHIBITION OF URIDINE RIBONUCLEOTIDE SYNTHESIS BY 5-HALOGENATED-2'-DEOXYURIDINE ANALOGUES.
Topics: Antiviral Agents; Brain; Deoxyuridine; Enzyme Inhibitors; Halogenation; Keratitis; Keratitis, Dendritic; Nucleosides; Nucleotides; Organic Chemicals; Orotic Acid; Pharmacology; Rats; Research; Ribonucleotides; Thymidine; Uridine | 1964 |
HEREDITARY OROTIC ACIDURIA AND MEGALOBLASTIC ANAEMIA: A SECOND CASE, WITH RESPONSE TO URIDINE.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Examination; Child; Fluids and Secretions; Folic Acid; Humans; Infant; Metabolism, Inborn Errors; Nucleosides; Orotic Acid; Prognosis; Purine-Pyrimidine Metabolism, Inborn Errors; Pyridoxine; Thyroxine; Uridine; Urine; Vitamin B 12 | 1965 |
[STUDY OF THE PASSAGE OF CERTAIN PRECURSORS OF NUCLEIC ACIDS FROM THE CEREBROSPINAL FLUID INTO THE CENTRAL NERVOUS SYSTEM].
Topics: Adenine; Blood; Blood-Brain Barrier; Carbon Isotopes; Guanine; Nucleic Acids; Nucleosides; Nucleotides; Orotic Acid; Physiology; Radiometry; Rats; Research; Uracil; Uridine | 1964 |
PROPERTIES ODF DIPLOID CELL STRAINS DEVELOPED FROM PATIENTS WITH AN INHERITED ABNORMALITY OF URIDINE BIOSYNTHESIS.
Topics: Carboxy-Lyases; Diploidy; Genetics, Medical; Humans; Mutation; Nucleosides; Nucleotidyltransferases; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Tissue Culture Techniques; Uridine; Urine | 1964 |
OROTIC ACID-INDUCED FATTY LIVER. METABOLIC STUDIES IN CONVENTIONAL AND GERM-FREE RATS.
Topics: Diet; Fatty Liver; Feces; Germ-Free Life; Intestinal Absorption; Intestines; Metabolism; Nucleosides; Orotic Acid; Rats; Research; Toxicology; Uracil; Uracil Nucleotides; Uridine; Urine | 1965 |
ENZYMIC PREPARATION OF RADIOACTIVE OROTIDINE 5'-PHOSPHATE.
Topics: Carbon Isotopes; Carboxy-Lyases; Chemical Phenomena; Chemistry; Enzyme Inhibitors; Liver; Neurospora; Nucleotides; Orotic Acid; Phosphates; Radiometry; Rats; Research; Spectrum Analysis; Uridine | 1965 |
TRANSCARBAMYLASE ACTIVITY IN FETAL LIVER AND IN LIVER OF PARTIALLY HEPATECTOMIZED PARABIOTIC RATS.
Topics: Cell Division; Enzyme Precursors; Erythrocyte Count; Fetus; Guinea Pigs; Hepatectomy; Ligases; Liver; Liver Diseases; Liver Regeneration; Nucleosides; Ornithine; Ornithine Carbamoyltransferase; Orotic Acid; Parabiosis; Pyrimidines; Rats; Research; Transferases; Uracil; Urea; Uridine | 1965 |
OROTIDINE -5'-PHOSPHATE PYROPHOSPHORYLASE OF WHEAT EMBRYOS.
Topics: Autoradiography; Biochemical Phenomena; Biochemistry; Chromatography; Copper; Diphosphates; Glucosyltransferases; Magnesium; Manganese; NAD; Orotate Phosphoribosyltransferase; Orotic Acid; Oxidoreductases; Research; Triticum; Uracil Nucleotides; Uridine | 1965 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
A new ribose nucleoside from Neurospora; "orotidine".
Topics: Humans; Neurospora; Nucleosides; Orotic Acid; Ribose; Uridine | 1951 |
Alterations in pyrimidine nucleotide metabolism as an early signal during the execution of programmed cell death in tobacco BY-2 cells.
Topics: Apoptosis; Dactinomycin; Hydrogen Peroxide; Nicotiana; Nitric Oxide; Orotic Acid; Phosphotransferases (Alcohol Group Acceptor); Pyrimidine Nucleotides; Signal Transduction; Thymidine; Time Factors; Transferases; Uracil; Uridine | 2004 |
Inhibition of de novo pyrimidine synthesis in growing potato tubers leads to a compensatory stimulation of the pyrimidine salvage pathway and a subsequent increase in biosynthetic performance.
Topics: Down-Regulation; Enzyme Activation; Gene Expression Regulation, Plant; Multienzyme Complexes; Oligoribonucleotides, Antisense; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Plant Tubers; Plants, Genetically Modified; Promoter Regions, Genetic; Pyrimidines; Signal Transduction; Solanum tuberosum; Up-Regulation; Uridine | 2005 |
Comparative studies on pyrimidine metabolism in excised cotyledons of Pinus radiata during shoot formation in vitro.
Topics: Benzyl Compounds; Cotyledon; In Vitro Techniques; Kinetin; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosyltransferases; Pinus; Plant Shoots; Purines; Pyrimidine Nucleotides; Pyrimidines; Uracil; Uridine; Uridine Kinase | 2007 |
The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
Topics: Azacitidine; Bromodeoxyuridine; Decitabine; Deoxyuridine; DNA Damage; Escherichia coli; Escherichia coli Proteins; Fluorouracil; Models, Biological; Molecular Structure; Mutation; N-Glycosyl Hydrolases; Nucleotidases; Orotic Acid; Substrate Specificity; Thymidine Monophosphate; Uridine | 2007 |
Distinct fluctuations in nucleotide metabolism accompany the enhanced in vitro embryogenic capacity of Brassica cells over-expressing SHOOTMERISTEMLESS.
Topics: Adenine Phosphoribosyltransferase; Adenosine Kinase; Biological Transport; Brassica napus; Carbon Isotopes; Down-Regulation; Gene Expression; Germination; Meristem; Orotic Acid; Plant Proteins; Pollen; Purine Nucleotides; Pyrimidine Nucleosides; Time Factors; Uracil; Uridine | 2011 |
Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biomass; Cellulose; Fluorouracil; Isoenzymes; Light; Lignin; Mutagenesis, Insertional; Orotic Acid; Pentosyltransferases; Phenotype; Plant Leaves; Plants, Genetically Modified; Plastids; Recombinant Fusion Proteins; Seeds; Starch; Uracil; Uridine; Uridine Kinase | 2011 |
Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates.
Topics: Biocatalysis; Buffers; Decarboxylation; Enzyme Activation; Enzyme Stability; Kinetics; Mutant Proteins; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Osmolar Concentration; Phosphites; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity; Uridine; Uridine Monophosphate | 2013 |
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.
Topics: Amides; Animals; Biological Transport; Cell Line; Deoxyuridine; Fluorouracil; Gene Knockout Techniques; Mice; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Transfection; Trypanocidal Agents; Trypanosoma brucei brucei; Uracil; Uridine; Uridine Monophosphate; Virulence | 2013 |
In brief: Uridine triacetate (Xuriden) for hereditary orotic aciduria.
Topics: Acetates; Administration, Oral; Biomarkers; Drug Costs; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors; Treatment Outcome; Uridine | 2016 |
Elevated plasma dihydroorotate in Miller syndrome: Biochemical, diagnostic and clinical implications, and treatment with uridine.
Topics: Abnormalities, Multiple; Child, Preschool; Dihydroorotate Dehydrogenase; Genotype; Humans; Limb Deformities, Congenital; Male; Mandibulofacial Dysostosis; Micrognathism; Mutation; Orotic Acid; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Uridine | 2016 |
Mild orotic aciduria in UMPS heterozygotes: a metabolic finding without clinical consequences.
Topics: Anemia, Megaloblastic; Child; Child, Preschool; Female; Heterozygote; Humans; Infant; Intellectual Disability; Male; Multienzyme Complexes; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Urea Cycle Disorders, Inborn; Uridine | 2017 |
Metabolic engineering generates a transgene-free safety switch for cell therapy.
Topics: Animals; Base Sequence; Cell Proliferation; Cell- and Tissue-Based Therapy; Gene Editing; Gene Targeting; Genome, Human; Humans; K562 Cells; Male; Metabolic Engineering; Mice; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pluripotent Stem Cells; Transgenes; Uridine | 2020 |
Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study.
Topics: Adult; Aged; Black or African American; Case-Control Studies; Collagen; Coronary Disease; Effect Modifier, Epidemiologic; Female; Heart Disease Risk Factors; Heart Failure; Homoarginine; Humans; Hypertrophy, Left Ventricular; Incidence; Longitudinal Studies; Male; Metabolomics; Middle Aged; Nitric Oxide; Orotic Acid; Polyamines; Proline; Proportional Hazards Models; Pyrimidines; Risk; RNA Processing, Post-Transcriptional; Spermine; Stroke Volume; Uridine; White People | 2021 |