uridine has been researched along with methotrexate in 90 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 68 (75.56) | 18.7374 |
| 1990's | 18 (20.00) | 18.2507 |
| 2000's | 2 (2.22) | 29.6817 |
| 2010's | 2 (2.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Irvin, AD; Stagg, DA | 1 |
| Jackson, RC | 1 |
| Grindey, GB; Mihich, E | 1 |
| Kaufmann, M; Kubli, F; Reus, W; Volm, M; von Fournier, D | 1 |
| Johnson, B; Westergaard, O | 1 |
| Hummel, H; Mattern, J; Volm, M | 1 |
| Young, RC | 1 |
| Brox, LW; Henderson, JF; Hryniuk, WM; Tamaoki, T | 1 |
| Håkansson, L | 1 |
| Dahn, I; Håkansson, L; Huldt, B | 1 |
| Rasmussen, L; Zeuthen, E | 1 |
| DeLapp, NW; Karasek, MA | 1 |
| Aran, JM; Plagemann, PG | 1 |
| Chan, PK | 1 |
| Adachi, S; Akiyama, Y; Hashimoto, H; Kasai, Y; Kubota, M; Mikawa, H; Sano, H; Shimizu, T | 1 |
| Agarwal, RP; Bruce-Gregorios, JH; Lin, L; Oracion, A; Ramirez, A | 1 |
| Martin, DS; Nord, LD | 1 |
| Cao, S; Wu, S; Xue, Y; Zhen, Y | 1 |
| Dorr, RT | 1 |
| Choi, WY; Kim, DJ; Nam, HW; Youn, JH | 1 |
| Martin, DS | 1 |
| Kemeny, NE; Martin, DS; Schneider, A | 1 |
| Booker, L; Browman, GP; Spiegl, P | 1 |
| Booker, L; Browman, GP; Rosowsky, A; Spiegl, P | 1 |
| Plagemann, PG; Wohlhueter, RM | 1 |
| Goerttler, K; Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Mattern, J; Volm, M; Wayss, K | 2 |
| Seidel, HJ; Wegner, LA | 1 |
| Andersen, HA | 3 |
| Yu, KY | 1 |
| Lang, A; Nitsan, J | 1 |
| Kummer, D | 1 |
| Zeuthen, E | 2 |
| Sprecher-Goldberger, S | 1 |
| Baluda, MA; Brodetsky, AM; Knudson, AG | 1 |
| Donsbach, RC; Sirotnak, FM | 1 |
| McCullough, JL; Weinstein, GD | 1 |
| Gallo, RC; Levine, P; Smith, RG; Ting, RC; Whang-Peng, J | 1 |
| DaCosta, M; Kamen, B; Rothenberg, SP | 1 |
| McDonald, CJ | 1 |
| Jeffery, WR | 1 |
| Cox, RP; Malathi, VG; Meyers, R; Silber, R | 1 |
| Byfield, JE; Karlsson, U | 1 |
| Radnay, J; Rozenszajn, LA | 1 |
| Beer, CT; Kajiwara, K; Mueller, GC | 1 |
| Fromer, JL | 1 |
| Salen, G; Schumacher, HR | 1 |
| Liuzzo, B; Lo Curto, M | 1 |
| Hryniuk, WM | 1 |
| Rubaltelli, FF | 1 |
| Margolis, S; Philips, FS; Sternberg, SS | 1 |
| Furness, ME; Harrap, KR; Hart, LI; Hill, BT | 1 |
| Bertino, JR; Hryniuk, WM | 1 |
| Brinkmann, W; Dörmer, P; Muschalik, P | 1 |
| Villadsen, IS; Zeuthen, E | 1 |
| Herbert, V; Kelly, A; Metz, J; Swett, VC; Waxman, S | 1 |
| Pearlman, RE; Westergaard, O | 1 |
| Evans, EA | 1 |
| Chu, BC; Whiteley, JM | 1 |
| Campisi, J; Pardee, AB | 1 |
| Keiding, N; Larsen, JK; Møller, U | 1 |
| Fukushima, S; Kubota, Y; Miura, T; Moriyama, M; Ooshima, H; Shiozaki, H; Shuin, T | 1 |
| Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 1 |
| Andersen, HA; Keiding, J | 1 |
| Klenow, S | 1 |
| Flintoff, WF; Weber, M | 1 |
| Barbet, J; Leserman, LD; Machy, P | 1 |
| Fuska, J; Fusková, A; Proksa, B | 1 |
| Koizumi, S; Miura, M; Taniguchi, N; Ueno, Y; Yamagami, M | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| Hu, JL; Qi, CQ; Su, J; Zhen, YC | 1 |
| Blaney, JM; Gschwend, DA; Kuntz, ID; Meng, EC | 1 |
| Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L | 1 |
| Adami, M; Fenu, S; Nardelli, D; Nicolini, C; Zolfino, I | 1 |
| Bertino, J; Casper, E; Christman, K; Colofiore, J; Kelsen, D; Martin, DS; Quan, V; Saltz, L; Schwartz, GK | 1 |
| Fairbanks, LD; Hawrylowicz, CM; Kirschbaum, B; Qiu, Y; Richards, DF; Rückemann, K; Simmonds, HA; Swaminathan, R | 1 |
| Kaznowska, Z; Simmonds, HA; Smoleńska, Z; Smoleński, RT; Zarówny, D | 1 |
| TEMIN, HM | 1 |
| HODAS, S; YOUNG, CW | 1 |
| WELCH, AD | 1 |
| Aringer, M; Eselböck, D; Grisar, J; Köller, MD; Pietschmann, P; Smolen, JS; Steiner, CW; Stummvoll, GH; Wagner, L; Zierhut, B; Zwölfer, B | 1 |
| Kemeny, NE; Leonard, GD | 1 |
| Dührsen, U; Khandanpour, C; Röth, A | 1 |
6 review(s) available for uridine and methotrexate
| Article | Year |
|---|---|
Multiple basis of combination chemotherapy.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Antagonism; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Humans; Leucovorin; Mercaptopurine; Methotrexate; Neoplasms; Neoplasms, Experimental; Uridine | 1977 |
Chemoprotectants for cancer chemotherapy.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cisplatin; Cyclophosphamide; Fluorouracil; Humans; Ifosfamide; Leucovorin; Mesna; Methotrexate; Neoplasms; Razoxane; Sulfhydryl Compounds; Uridine | 1991 |
[Some developments in psoriasis research abroad].
Topics: Aza Compounds; Female; Humans; Hydroxyurea; Male; Mechlorethamine; Methotrexate; Psoriasis; Uridine | 1974 |
Synchronization of the Tetrahymena cell cycle.
Topics: Animals; Antimalarials; Carbon Isotopes; Cell Division; Cell Nucleus; Culture Media; DNA; DNA Replication; Floxuridine; Hot Temperature; Methotrexate; Morphogenesis; Nucleosides; Protein Biosynthesis; Temperature; Tetrahymena; Tetrahymena pyriformis; Thymidine; Time Factors; Transcription, Genetic; Tritium; Uridine | 1971 |
Psoriasis.
Topics: Administration, Topical; Anti-Inflammatory Agents; Antimetabolites; Aza Compounds; Glucocorticoids; Humans; Hydroxyurea; Methotrexate; Psoriasis; Salicylates; Tars; Uridine | 1974 |
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
2 trial(s) available for uridine and methotrexate
| Article | Year |
|---|---|
A phase I trial of a modified, dose intensive FAMTX regimen (high dose 5-fluorouracil+doxorubicin+high dose methotrexate+leucovorin) with oral uridine rescue.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasms; Neutropenia; Uridine | 1996 |
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.
Topics: Adenosine; Adenosine Triphosphate; Adult; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Chronic Disease; Cytidine Triphosphate; Erythrocytes; Female; Guanosine Triphosphate; Humans; Hypoxanthine; Methotrexate; Middle Aged; Ribonucleotides; Uric Acid; Uridine | 1999 |
82 other study(ies) available for uridine and methotrexate
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
[Sensitivity tests of malignant tumours against cytostatic agents in vitro and in vivo/studies on the mouse sarcoma 180 (author's transl)].
Topics: Animals; Antineoplastic Agents; Biological Transport; Bleomycin; Cell Membrane Permeability; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Fluorouracil; Methotrexate; Mice; Mice, Inbred Strains; Podophyllin; Sarcoma 180; Uridine | 1975 |
Theileria parva: purine and pyrimidine metabolism and the action of folate antagonists in parasitized bovine lymphoid cells.
Topics: Adenine; Aminopterin; Animals; Azaguanine; Cattle; Cells, Cultured; Culture Media; Eukaryota; Floxuridine; Folic Acid Antagonists; Guanine; Hypoxanthines; Lymphocytes; Methotrexate; Purines; Pyrimidine Nucleosides; Theileriasis; Thymidine; Uridine | 1977 |
The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.
Topics: 3-Deazauridine; Animals; Cell Line; DNA, Neoplasm; Floxuridine; Liver Neoplasms, Experimental; Methotrexate; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Uridine | 1978 |
[Short-term incubation in vitro with precursors of nucleic acids on human primary tumors and metastases of carcinoma of the breast (author's transl)].
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclophosphamide; Deoxyuridine; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Female; Humans; Lymphatic Metastasis; Methotrexate; Thymidine; Uridine | 1978 |
Accumulation of replicative DNA intermediates in Tetrahymena after excision-repairable damage to DNA.
Topics: Animals; Bromodeoxyuridine; Centrifugation, Density Gradient; DNA Repair; Methotrexate; Molecular Weight; Tetrahymena pyriformis; Thymine; Uridine | 1976 |
[Correlation between the effects of cytostatic agents on leukemia L 1210 in vivo and in the short term test in vitro (author's transl)].
Topics: Animals; Cell Count; Culture Techniques; Deoxyuridine; Doxorubicin; Female; Leucine; Leukemia L1210; Methotrexate; Mice; Thymidine; Time Factors; Uridine; Vinblastine | 1977 |
Kinetic aids to proper chemotherapeutic scheduling: labeled nucleoside incorporation studies in vivo.
Topics: Animals; Bone Marrow; Cell Survival; Cyclophosphamide; DNA, Neoplasm; Drug Administration Schedule; Fluorouracil; Granulocytes; Intestinal Mucosa; Kinetics; Lomustine; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Pyrimidine Nucleosides; Thymidine; Uridine | 1976 |
Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells.
Topics: Adenine; Adenosine Triphosphate; Animals; Cell Line; Cytosine Nucleotides; Depression, Chemical; DNA; Guanine; Guanosine Triphosphate; Hypoxanthines; Leucine; Leukemia, Lymphoid; Methotrexate; Mice; Purines; RNA; Thymidine; Time Factors; Uracil Nucleotides; Uridine | 1975 |
Mycosis fungoides cooperative study.
Topics: Aza Compounds; Cyclophosphamide; Dermatology; Drug Therapy, Combination; Humans; Immunotherapy; Leucovorin; Methotrexate; Mycosis Fungoides; National Institutes of Health (U.S.); Statistics as Topic; United States; Uridine | 1975 |
Effect of cytostatic drugs on nucleic acid synthesis in mouse thymocytes and chick embryo cells.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytarabine; Dactinomycin; Deoxyadenosines; Deoxyuridine; DNA; Fluorouracil; Melphalan; Methotrexate; Mice; Mice, Inbred Strains; Thymidine; Thymus Gland; Triaziquone; Tritium; Uridine; Vinblastine | 1975 |
The effect of cytostatic drugs on the synthesis of DNA in adenocarcinomas of the stomach. An in vitro study.
Topics: Adenocarcinoma; Antineoplastic Agents; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; In Vitro Techniques; Melphalan; Methotrexate; Stomach Neoplasms; Thymidine; Tritium; Uridine; Vinblastine | 1975 |
Uridine as an inhibitor of thymidine utilization and DNA synthesis in L cells with impeded function of thymidylate synthetase.
Topics: Cell Division; Cytidine; DNA; L Cells; Methotrexate; Protein Biosynthesis; Purine Nucleosides; Pyrimidine Nucleosides; Thymidine; Thymidylate Synthase; Uridine | 1976 |
Importance of pyrimidine nucleotide salvage pathways for DNA synthesis in skin.
Topics: Animals; Animals, Newborn; Azauridine; Cytidine; DNA; Hydroxyurea; Liver; Methotrexate; Mice; Orotic Acid; Pyrimidine Nucleotides; Rabbits; RNA; Skin; Thymidine; Time Factors; Uridine | 1976 |
Nucleoside transport-deficient mutants of PK-15 pig kidney cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Line; Clone Cells; Cytarabine; DNA; Escherichia coli; Flow Cytometry; Floxuridine; Hypoxanthine; Hypoxanthines; Kidney; Kinetics; Membrane Proteins; Methotrexate; Mutation; Nucleoside Transport Proteins; Nucleosides; Plasmids; Recombinant Proteins; Swine; Thymidine; Transfection; Tubercidin; Uridine | 1992 |
Characterization and cellular localization of nucleophosmin/B23 in HeLa cells treated with selected cytotoxic agents (studies of B23-translocation mechanism).
Topics: Autoradiography; Camptothecin; Cell Nucleolus; Dactinomycin; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; HeLa Cells; Humans; Kinetics; Lysine; Methotrexate; Nuclear Proteins; Nucleophosmin; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Processing, Post-Translational; Tritium; Uridine | 1992 |
Effect of high-dose methotrexate on plasma hypoxanthine and uridine levels in patients with acute leukemia or non-Hodgkin lymphoma in childhood.
Topics: Adolescent; Child; Humans; Hypoxanthine; Hypoxanthines; Lymphoma, Non-Hodgkin; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Uridine | 1992 |
Effects of methotrexate on RNA and purine synthesis of astrocytes in primary culture.
Topics: Animals; Astrocytes; Formates; Glycine; Methotrexate; Purine Nucleotides; Rats; RNA; Tritium; Uridine | 1991 |
Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Fluorouracil; Mammary Neoplasms, Experimental; Methotrexate; Mice; Ornithine Decarboxylase; RNA; Thymidine Kinase; Thymidylate Synthase; Tritium; Uridine | 1991 |
Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cytarabine; Drug Synergism; Female; Humans; Leukemia L1210; Leukemia P388; Male; Methotrexate; Mice; Mice, Inbred DBA; Plant Extracts; Tea; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1991 |
Effects of pyrimidine salvage inhibitors on uracil incorporation of Toxoplasma gondii.
Topics: Animals; DNA; Folic Acid Antagonists; Methotrexate; Pyrimethamine; Thymidylate Synthase; Toxoplasma; Uracil; Uridine | 1990 |
Introduction to 5-fluorouracil modulation.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Uridine | 1990 |
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine | 1990 |
Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate.
Topics: Cell Division; Cell Line; Drug Antagonism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Lymphoid Tissue; Methotrexate; Polyglutamic Acid; Tetrahydrofolates; Thymidine; Uridine | 1985 |
Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines.
Topics: Biological Transport; Cell Division; Cell Line; Drug Antagonism; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Lymphoid Tissue; Methotrexate; Tetrahydrofolates; Uridine | 1985 |
S49 mouse lymphoma cells are deficient in hypoxanthine transport.
Topics: Adenine; Animals; Biological Transport; Cell Line; Cricetinae; Cricetulus; Dipyridamole; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lymphoma; Methotrexate; Mice; Permeability; Thymidine; Uridine; Uridine Kinase | 1986 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation; Drug Resistance; Fluorouracil; Humans; Methods; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Procarbazine; Radioisotopes; Rats; Scintillation Counting; Thymidine; Triaziquone; Uridine | 1974 |
[The effects of cytostatic agents on short-term cultures (3H-uridine incorporation) and tissue cultures (cell counts) from human tumors (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; In Vitro Techniques; Methods; Methotrexate; Neoplasms; Ovarian Neoplasms; Podophyllin; Suspensions; Time Factors; Triaziquone; Tritium; Uridine | 1974 |
[Estimation of tumor sensitivity in vitro. I. Comparative studies with the Jensen sarcoma in vivo and in vitro after 1-hour-incubation].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Autoradiography; Cycloparaffins; Dactinomycin; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Methods; Methotrexate; Mustard Compounds; Neoplasm Transplantation; Nucleosides; Rats; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Time Factors; Triaziquone; Tritium; Uridine; Vinblastine | 1969 |
Replication of macronuclear DNA in the cytoplasm of Tetrahymena pyriformis.
Topics: Autoradiography; Bromodeoxyuridine; Cell Division; Cell Nucleus; Centrifugation, Density Gradient; Cytoplasm; DNA; DNA Replication; Hybridization, Genetic; Methotrexate; Tetrahymena pyriformis; Tritium; Uridine | 1974 |
Relations among cell growth, DNA synthesis, and gibberellin action.
Topics: Carbon Isotopes; Chloramphenicol; Dactinomycin; DNA; Ethanol; Floxuridine; Gibberellins; Methotrexate; Mitomycins; Plants, Edible; Puromycin; RNA; Thymidine; Tritium; Uridine | 1967 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
The existence of two different metabolic patterns for the synthesis of RNA viruses.
Topics: Adenine; Animals; Antimetabolites; Chick Embryo; Culture Media; Dactinomycin; Enterovirus; Fibroblasts; Formates; Histones; Influenza A virus; Methotrexate; Nucleosides; Orotic Acid; Phenylalanine; Puromycin; Radiation Effects; RNA Viruses; RNA, Viral; Thymidine; Ultraviolet Rays; Uridine | 1966 |
Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine.
Topics: Animals; Antiviral Agents; Avian Leukosis Virus; Cell Division; Chick Embryo; Culture Techniques; DNA, Viral; Fibroblasts; Floxuridine; Methotrexate; RNA, Viral; Thymidine; Tritium; Uridine; Virus Replication | 1967 |
The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.
Topics: Animals; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Dose-Response Relationship, Drug; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolate Dehydrogenase; Thymidine; Time Factors; Tritium; Uridine | 1974 |
Effect of lipid-soluble esters of methotrexate on DNA synthesis in human skin.
Topics: Aminopterin; Depression, Chemical; DNA; Esters; Humans; Lipids; Methotrexate; Pyrimethamine; Skin; Solubility; Temperature; Time Factors; Trimethoprim; Tritium; Uridine | 1974 |
Selective toxicity of rifamycin derivatives for leukaemic human leucocytes.
Topics: Antibiotics, Antineoplastic; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cell Differentiation; Cells, Cultured; DNA Nucleotidyltransferases; DNA, Neoplasm; Humans; Hydroxyurea; Kinetics; Leukemia; Leukocytes; Lymphocytes; Mercaptopurine; Methotrexate; Rifampin; RNA, Neoplasm; Thymidine; Tritium; Uridine | 1972 |
DNA synthesis in chronic myelogenous leukemia cells: comparison of results in cells containing folate binding factor to replicating cells without binder.
Topics: Anemia, Hypochromic; Binding Sites; Bone Marrow Cells; Cells, Cultured; Deoxyuridine; DNA; DNA Replication; Folic Acid; Folic Acid Antagonists; Humans; Leukemia, Myeloid; Leukocytes; Lymphoma, Large B-Cell, Diffuse; Methotrexate; RNA; Thymidine; Tritium; Tuberculosis, Lymph Node; Uridine | 1972 |
Evidence for a temporal incompatibility between DNA replication and division during the cell cycle of Tetrahymena.
Topics: Adenosine; Animals; Autoradiography; Carbon Isotopes; Cell Count; Cell Division; Cell Nucleus; DNA; DNA Replication; Germ-Free Life; Hot Temperature; Leucine; Methotrexate; Micromanipulation; Mitosis; Tetrahymena pyriformis; Thymidine; Time Factors; Tritium; Uridine | 1972 |
Induced elimination of DNA from macronucleus of Tetrahymena pyriformis.
Topics: Animals; Autoradiography; Cell Division; Cell Nucleus; Cytoplasm; DNA; DNA Replication; Isotope Labeling; Methotrexate; Temperature; Tetrahymena pyriformis; Thymidine; Time Factors; Tritium; Uridine | 1972 |
Requirements for DNA replication preceding cell division in Tetrahymena pyriformis.
Topics: Animals; Carbon Isotopes; Cell Division; Centrifugation, Density Gradient; DNA Replication; Hot Temperature; Methotrexate; Tetrahymena pyriformis; Thymidine; Uridine | 1972 |
Studies on nucleoside deaminase. Increase in activity in HeLa cell cultures caused by cytosine arabinoside.
Topics: Alkaline Phosphatase; Aminohydrolases; Antimetabolites; Carbon Isotopes; Cell Fractionation; Culture Media; Cycloheximide; Cytarabine; Cytidine; Deamination; DNA; DNA Nucleotidyltransferases; Glucosephosphate Dehydrogenase; HeLa Cells; L-Lactate Dehydrogenase; Leucine; Methotrexate; Nucleosides; Protein Biosynthesis; Thymidine; Time Factors; Tritium; Uridine | 1973 |
Inhibition of replication and differentiation in malignant mouse neuroblasts.
Topics: Amino Acids; Animals; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Cytarabine; DNA Replication; Methotrexate; Mice; Microscopy, Electron; Neoplasm Proteins; Neoplasms, Experimental; Neuroblastoma; RNA; Thymidine; Tritium; Uridine | 1973 |
The effect of methotrexate on transformation and mitosis of normal human blood lymphocytes in vitro.
Topics: Blood Proteins; Carbon Radioisotopes; Cells, Cultured; Densitometry; DNA; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Methotrexate; Mitosis; Phenylalanine; RNA; Thymidine; Time Factors; Tritium; Uridine | 1974 |
Synchronization of HeLa cells with 2,3-dihydro-1-H-imidazo(1,2-b)pyrazole.
Topics: Adenosine; Carbon Radioisotopes; Cell Division; Depression, Chemical; DNA; HeLa Cells; Humans; Imidazoles; Leucine; Methotrexate; Mitosis; Protein Biosynthesis; Pyrazoles; RNA; Thymidine; Time Factors; Tritium; Uridine | 1974 |
The effects of cytostatic drugs on transplanted tumours. An investigation of the correlation between in vivo and in vitro results.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cytarabine; Daunorubicin; Fluorouracil; Melanoma; Methotrexate; Mice; Neoplasm Transplantation; Plasmacytoma; Procarbazine; Rats; Thymidine; Tritium; Uridine | 1974 |
Reticulum cell lymphoma.
Topics: Facial Neoplasms; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Middle Aged; Skin Neoplasms; Uridine | 1970 |
Metabolism of leukocytes in a case of acute leukemia.
Topics: Autoradiography; Child; DNA; Female; Folic Acid; Humans; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Methotrexate; Prednisone; Thymidine; Tritium; Uridine; Vincristine; Vitamin B 12 | 1967 |
PHA short-term culture of lymphocytes in acute leukemia during remission. Relation with therapy.
Topics: Acute Disease; Autoradiography; Child; Child, Preschool; Female; Humans; Lectins; Leukemia; Lymphocyte Activation; Lymphocytes; Mercaptopurine; Methotrexate; Remission, Spontaneous; RNA; Tritium; Uridine | 1971 |
Purineless death as a link between growth rate and cytotoxicity by methotrexate.
Topics: Animals; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Hypoxanthines; In Vitro Techniques; Leucine; Leukemia, Experimental; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidine; Tritium; Uridine | 1972 |
Serum conjugated bilirubin in newborns of mothers treated with immunosuppressive drugs.
Topics: Bilirubin; Coombs Test; Enzyme Activation; Erythroblastosis, Fetal; Female; Glucuronates; Humans; Immunosuppression Therapy; Infant, Newborn; Liver; Mercaptopurine; Methotrexate; Pregnancy; Transferases; Uridine | 1972 |
The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.
Topics: Animals; Body Weight; Depression, Chemical; DNA; Epithelial Cells; Folic Acid Antagonists; Intestinal Mucosa; Intestine, Small; Lethal Dose 50; Liver; Male; Methotrexate; Mice; Mitosis; Organ Size; Phosphates; Phosphorus Isotopes; Thymidine; Tritium; Uridine | 1971 |
Sites of action of amethopterin: intrinsic and acquired drug resistance.
Topics: Animals; Binding Sites; Biological Transport; Cells, Cultured; DNA, Neoplasm; Drug Resistance; Female; Folic Acid; Kinetics; Leukemia L1210; Lymphoma; Methotrexate; Protein Binding; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Time Factors; Tritium; Uridine | 1971 |
Growth rate and cell kill.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Humans; Leukemia L1210; Leukemia, Experimental; Methotrexate; Mice; Thymidine; Time Factors; Tritium; Uridine | 1971 |
[A new method for the determination of the rate of DNA-synthesis in bone marrow cells in vitro].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Culture Media; Culture Techniques; DNA; Methotrexate; Models, Biological; Nucleosides; Rats; Thymidine; Tritium; Uridine | 1969 |
Synchronization of DNA synthesis in Tetrahymena populations by temporary limitation of access to thymine compounds.
Topics: Animals; Cell Division; Culture Techniques; DNA; DNA Replication; Methotrexate; Protein Biosynthesis; RNA; Tetrahymena; Thymidine; Uridine | 1970 |
Thymine starvation by inhibition of uptake and synthesis of thymine-compounds in Tetrahymena.
Topics: Cell Division; DNA; Hot Temperature; Methotrexate; Nucleosides; Tetrahymena; Thymidine; Thymine; Tritium; Uracil; Uracil Nucleotides; Uridine | 1968 |
Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans.
Topics: Anemia, Macrocytic; Bone Marrow; Bone Marrow Cells; Deoxyuridine; DNA; Female; Folic Acid; Folic Acid Deficiency; Humans; In Vitro Techniques; Methionine; Methotrexate; Thymine; Tritium; Uridine; Vitamin B 12; Vitamin B 12 Deficiency | 1968 |
DNA polymerase activity in methotrexate plus uridine treated Tetrahymena.
Topics: Carbon Isotopes; Culture Techniques; Dactinomycin; DNA Nucleotidyltransferases; Leucine; Methotrexate; Protein Biosynthesis; RNA; Tetrahymena; Ultraviolet Rays; Uridine | 1969 |
Control of self-irradiation decomposition of tritium-labelled compounds at high specific activity.
Topics: Alcohols; Drug Stability; Ethanol; Folic Acid; Formates; Histidine; Leucine; Methotrexate; Nucleosides; Penicillin G; Radiation-Protective Agents; Thymidine; Tritium; Tyrosine; Uridine | 1966 |
The interaction of carrier-bound methotrexate with L1210 cells.
Topics: Animals; Cells, Cultured; Dextrans; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Serum Albumin, Bovine; Temperature; Uridine | 1980 |
Cellular mutations and drug resistance probed by herpes simplex virus.
Topics: Animals; Bleomycin; Carcinoma, Squamous Cell; Chlorocebus aethiops; Drug Resistance; Fibroblasts; Fluorescent Antibody Technique; Fluorouracil; Humans; Methotrexate; Mice; Mutation; Simplexvirus; Thioguanine; Uridine | 1981 |
Effect of methotrexate on cells in a keratinized epithelium with an active thymidine salvage pathway assessed by autoradiography.
Topics: Animals; Autoradiography; Cell Cycle; Cheek; Cricetinae; DNA Replication; Epithelial Cells; Epithelium; Flow Cytometry; Keratins; Kinetics; Male; Mesocricetus; Methotrexate; Mouth Mucosa; Thymidine; Tritium; Uridine | 1984 |
Combination chemotherapy for metastatic urinary bladder cancer with 5-FU, vincristine, bleomycin, cyclophosphamide, mitomycin, and methotrexate.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Transitional Cell; Cyclophosphamide; Female; Humans; Male; Methotrexate; Middle Aged; Mitomycins; Uridine; Urinary Bladder Neoplasms; Vincristine | 1984 |
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1983 |
Induction of DNA polymerase in Tetrahymena pyriformis.
Topics: Bromodeoxyuridine; DNA-Directed DNA Polymerase; Enzyme Induction; Methotrexate; Tetrahymena pyriformis; Ultraviolet Rays; Uridine | 1981 |
Inhibition of DNA synthesis does not influence the H1 histone synthesis in Tetrahymena pyriformis.
Topics: Animals; DNA Replication; Histones; Hydroxyurea; Kinetics; Methotrexate; Tetrahymena pyriformis; Uridine | 1982 |
Selection of wild-type revertants from methotrexate-resistant cells containing an altered dihydrofolate reductase.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance; Female; Fibroblasts; Genetic Techniques; Methotrexate; Ovary; Tetrahydrofolate Dehydrogenase; Uridine | 1980 |
Differential endocytosis of T and B lymphocyte surface molecules evaluated with antibody-bearing fluorescent liposomes containing methotrexate.
Topics: Ammonium Chloride; Animals; Antibodies; Antigens, Surface; B-Lymphocytes; Fluorescent Antibody Technique; Liposomes; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; T-Lymphocytes; Uridine | 1982 |
7,8-dihydro-5H-isoindolo[1,2-b] [3]benzazepine-5-ones. Part 2: In vitro effect of derivatives substituted at position 7 on leukemia P 388 cells.
Topics: Animals; Antineoplastic Agents; Benzazepines; Cell Division; Chemical Phenomena; Chemistry; Drug Synergism; In Vitro Techniques; Leukemia P388; Leukemia, Experimental; Methotrexate; Mice; Neoplasm Proteins; Structure-Activity Relationship; Time Factors; Uridine | 1982 |
Resistance of human bone marrow CFUC to high-dose methotrexate cytotoxicity.
Topics: Bone Marrow; Cell Survival; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Humans; Lymphocytes; Methotrexate; Phagocytes; Uridine | 1980 |
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; KB Cells; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1995 |
Orientational sampling and rigid-body minimization in molecular docking.
Topics: Carboxypeptidases; Carboxypeptidases A; Carrier Proteins; Computer Simulation; Crystallography; Dipeptides; Glucose; Ligands; Mathematical Computing; Methotrexate; Models, Chemical; Models, Molecular; Proteins; Ribonuclease, Pancreatic; Software; Tetrahydrofolate Dehydrogenase; Uridine | 1993 |
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine | 1993 |
Potentiometric alternating biosensing system for in continuum toxicity tests on cell population.
Topics: Animals; Antineoplastic Agents; Biosensing Techniques; Cell Count; CHO Cells; Cisplatin; Cricetinae; Electrophysiology; HeLa Cells; Humans; Hydrogen-Ion Concentration; Methotrexate; Potentiometry; Toxicity Tests; Uridine | 1996 |
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
Topics: Amidophosphoribosyltransferase; Arthritis, Rheumatoid; Bicarbonates; Cell Cycle; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glycine; Humans; Hypoxanthine; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Nucleotides; Phosphoribosyl Pyrophosphate; Phytohemagglutinins; Protein Biosynthesis; Proteins; Purines; Pyrimidines; Ribonucleotides; T-Lymphocytes; Uridine | 1999 |
THE PARTICIPATION OF DNA IN ROUS SARCOMA VIRUS PRODUCTION.
Topics: Avian Sarcoma Viruses; Chick Embryo; Dactinomycin; DNA; DNA, Viral; Fibroblasts; Metabolism; Methotrexate; Mice; Pharmacology; Radiometry; Research; RNA; RNA, Viral; Rous sarcoma virus; Thymidine; Tissue Culture Techniques; Tritium; Uridine; Virus Cultivation | 1964 |
ACUTE EFFECTS OF CYTOTOXIC COMPOUNDS ON INCORPORATION OF PRECURSORS INTO DNA, RNA, AND PROTEIN OF HELA MONOLAYERS.
Topics: Anti-Bacterial Agents; Antimetabolites; Dactinomycin; DNA; Floxuridine; HeLa Cells; Humans; Leucine; Mercaptopurine; Metabolism; Methotrexate; Nucleosides; Pharmacology; Proteins; Puromycin; Research; RNA; Streptonigrin; Thymidine; Tissue Culture Techniques; Triethylenemelamine; Urethane; Uridine; Vinblastine | 1965 |
[SOME MECHANISMS AND PROBLEMS OF SELECTIVE CHEMOTHERAPY].
Topics: Antineoplastic Agents; Drug Therapy; Humans; Methotrexate; Neoplasms; Nucleosides; Uracil; Uridine | 1965 |
Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells.
Topics: Antirheumatic Agents; Cell Adhesion; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Flow Cytometry; Humans; Hyaluronic Acid; Isoxazoles; Leflunomide; Leukocytes, Mononuclear; Methotrexate; Uridine | 2004 |
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex | 2006 |
Hand-foot syndrome: common presentation in an uncommon situation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Hand-Foot Syndrome; Humans; Lymphoma, Large B-Cell, Diffuse; Methotrexate; Middle Aged; Steroids; Uridine; Vincristine | 2013 |