uridine has been researched along with levoleucovorin in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (39.29) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Lietman, PS; Rogers, HJ | 1 |
| Grindey, GB; Mihich, E | 1 |
| Hsie, AW; Schröder, CH | 1 |
| Harrap, KR; Jackson, RC; Taylor, GA | 1 |
| Martin, DS; Nord, LD; Stolfi, RL | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Dorr, RT | 1 |
| Rustum, YM; Zhang, ZG | 1 |
| Berger, SH; Hakala, MT | 1 |
| Martin, DS | 1 |
| Kemeny, NE; Martin, DS; Schneider, A | 1 |
| Booker, L; Browman, GP; Spiegl, P | 1 |
| Nadal, JC; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Peters, GJ | 1 |
| Colofiore, JR; Martin, DS; Stolfi, RL | 1 |
| Booker, L; Browman, GP; Rosowsky, A; Spiegl, P | 1 |
| Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L | 1 |
| Bertino, J; Casper, E; Christman, K; Colofiore, J; Kelsen, D; Martin, DS; Quan, V; Saltz, L; Schwartz, GK | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Saif, MW; von Borstel, R | 1 |
| Kemeny, NE; Leonard, GD | 1 |
| Abbruzzese, JL; Cobb, PW; Doroshow, JH; Issell, BF; Macdonald, JS; McCoy, S; Patel, T; Yost, KJ | 1 |
| Codacci-Pisanelli, G; Noordhuis, P; Peters, GJ; van der Wilt, CL | 1 |
| McEvilly, M; Popelas, C; Tremmel, B | 1 |
| Callan, B; Callan, JF; Gao, J; Griffith, DM; Logan, KA; Love, M; McHale, AP; McKaig, T; Nesbitt, H; Taylor, M | 1 |
4 review(s) available for uridine and levoleucovorin
| Article | Year |
|---|---|
Multiple basis of combination chemotherapy.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Antagonism; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Humans; Leucovorin; Mercaptopurine; Methotrexate; Neoplasms; Neoplasms, Experimental; Uridine | 1977 |
Chemoprotectants for cancer chemotherapy.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cisplatin; Cyclophosphamide; Fluorouracil; Humans; Ifosfamide; Leucovorin; Mesna; Methotrexate; Neoplasms; Razoxane; Sulfhydryl Compounds; Uridine | 1991 |
Preclinical and clinical biochemical modulation of 5-fluorouracil by leucovorin and uridine.
Topics: Animals; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Mice; Tumor Cells, Cultured; Uridine | 1988 |
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
3 trial(s) available for uridine and levoleucovorin
| Article | Year |
|---|---|
A phase I trial of a modified, dose intensive FAMTX regimen (high dose 5-fluorouracil+doxorubicin+high dose methotrexate+leucovorin) with oral uridine rescue.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasms; Neutropenia; Uridine | 1996 |
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: a Southwest Oncology Group study.
Topics: Acetates; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Stomach Neoplasms; Survival Analysis; Uridine | 2006 |
21 other study(ies) available for uridine and levoleucovorin
| Article | Year |
|---|---|
The in vitro effect of trimethoprim on blastogenic transformation of human peripheral blood lymphocytes.
Topics: Autoradiography; Cells, Cultured; Concanavalin A; Deoxyuridine; Folic Acid; Formates; Humans; In Vitro Techniques; Leucine; Leucovorin; Lymphocyte Activation; Lymphocytes; Thymidine; Time Factors; Trimethoprim; Uridine | 1977 |
Mycosis fungoides cooperative study.
Topics: Aza Compounds; Cyclophosphamide; Dermatology; Drug Therapy, Combination; Humans; Immunotherapy; Leucovorin; Methotrexate; Mycosis Fungoides; National Institutes of Health (U.S.); Statistics as Topic; United States; Uridine | 1975 |
A temperature-sensitive auxotropic variant of Chinese hamster ovary cells.
Topics: Animals; Bromodeoxyuridine; Cell Line; Clone Cells; Cricetinae; Female; Glycine; Hypoxanthines; Leucovorin; Molecular Biology; Ovary; Temperature; Tetrahydrofolate Dehydrogenase; Thymidine; Uridine | 1975 |
Aspects of the biochemical pharmacology of cytembena.
Topics: Acrylates; Animals; Cell Division; DNA Nucleotidyltransferases; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid; Formate-Tetrahydrofolate Ligase; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Leucine; Leucovorin; Leukemia L1210; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine; Thymidine Kinase; Thymidylate Synthase; Uridine | 1975 |
Biochemical modulation of 5-fluorouracil with leucovorin or delayed uridine rescue. Correlation of antitumor activity with dosage and FUra incorporation into RNA.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Dose-Response Relationship, Drug; Fluorouracil; Leucovorin; Mammary Neoplasms, Experimental; Mice; RNA; Thymidylate Synthase; Time Factors; Uridine | 1992 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
Effects of diastereoisomers of 5-formyltetrahydrofolate on cellular growth, sensitivity to 5-fluoro-2'-deoxyuridine, and methylenetetrahydrofolate polyglutamate levels in HCT-8 cells.
Topics: Cell Division; Chromatography, High Pressure Liquid; Cytoplasm; Humans; In Vitro Techniques; Leucovorin; Pteroylpolyglutamic Acids; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine | 1991 |
Calcium leucovorin and 5-fluorouridine cytotoxicity.
Topics: Fluorodeoxyuridylate; Humans; Leucovorin; RNA, Ribosomal; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1990 |
Introduction to 5-fluorouracil modulation.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Uridine | 1990 |
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine | 1990 |
Differential calcium leucovorin protection of human lymphoid cell lines from methotrexate.
Topics: Cell Division; Cell Line; Drug Antagonism; Humans; Hypoxanthine; Hypoxanthines; Leucovorin; Lymphoid Tissue; Methotrexate; Polyglutamic Acid; Tetrahydrofolates; Thymidine; Uridine | 1985 |
Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma.
Topics: Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hematologic Diseases; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Uridine | 1989 |
Failure of high-dose leucovorin to improve therapy with the maximally tolerated dose of 5-fluorouracil: a murine study with clinical relevance?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Leucovorin; Mice; Neoplasms, Experimental; Uridine | 1988 |
Comparison of leucovorin protection from variety of antifolates in human lymphoid cell lines.
Topics: Biological Transport; Cell Division; Cell Line; Drug Antagonism; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Lymphoid Tissue; Methotrexate; Tetrahydrofolates; Uridine | 1985 |
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1983 |
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine | 1993 |
5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice.
Topics: Acetates; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Survival Rate; Tumor Burden; Uridine; Xenograft Model Antitumor Assays | 2006 |
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex | 2006 |
Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Mice; RNA; RNA Interference; Sensitivity and Specificity; Thymidylate Synthase; Uridine | 2008 |
Use of uridine triacetate for the management of fluorouracil overdose.
Topics: Antiemetics; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Overdose; Fluorouracil; Home Infusion Therapy; Humans; Leucovorin; Male; Medication Errors; Middle Aged; Ondansetron; Organoplatinum Compounds; Uridine | 2011 |
A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Mice; Microbubbles; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome; Uridine | 2021 |