uridine has been researched along with fluorouracil in 299 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 189 (63.21) | 18.7374 |
| 1990's | 49 (16.39) | 18.2507 |
| 2000's | 26 (8.70) | 29.6817 |
| 2010's | 31 (10.37) | 24.3611 |
| 2020's | 4 (1.34) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Faufmann, M; MAttern, J; Volm, M; Wayss, K | 1 |
| Hinderer, H; Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Pfefferkorn, ER; Pfefferkorn, LC | 1 |
| Danhauser, L; Rustum, YM; Wang, G | 1 |
| Houghton, JA; Houghton, PJ; Wooten, RS | 1 |
| Bowen, D; Diasio, RB; Goldman, ID | 1 |
| Hanas, RJ; Tlsty, TD; Wilkinson, DS | 1 |
| Gerok, W; Keppler, D; Pausch, J | 1 |
| Bíró, J | 1 |
| Jensen, KF | 1 |
| Glazer, RI; Peale, AL | 1 |
| Medina, D; Randerath, K; Tseng, WC | 1 |
| Andersen, O; Rønne, M | 1 |
| Crippa, M; Rungger, D | 1 |
| Berger, E | 1 |
| Young, RC | 1 |
| Håkansson, L | 1 |
| Enomoto, C; Sugiura, A; Tobita, K; Ueda, M | 1 |
| Catlin, JC; Guschlbauer, W | 1 |
| Dahn, I; Håkansson, L; Huldt, B | 1 |
| Endo, H; Kuwano, M; Tanaka, K | 1 |
| Akao, T; Fujimoto, S; Itoh, B; Koshizuka, I; Koyano, K | 1 |
| Fujiwara, Y; Morikage, T; Nishio, K; Ohe, Y; Ohmori, T; Saijo, N; Sugimoto, Y | 1 |
| Martin, DS; Nord, LD; Stolfi, RL | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O | 1 |
| Ophir, A | 1 |
| Kita, J; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O | 1 |
| Barberi-Heyob, M; Merlin, JL; Webér, B | 1 |
| Handschumacher, RE; Lentz, SK; Pizzorno, G; Wiegand, RA | 1 |
| Peters, GJ; Pinedo, HM; van Groeningen, CJ | 2 |
| Britt, JM; Hopp, RH; Leon, JA; Milam, AH; Mills, RP | 1 |
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| Martin, DS; Nord, LD | 1 |
| Kraal, I; Peters, GJ; Pinedo, HM | 1 |
| Dorr, RT | 1 |
| De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| Cha, S; Darnowski, JW; el Kouni, MH; Naguib, FN; Park, KS; Soong, SJ | 1 |
| Hirose, S; Kito, M; Takeshima, S; Urakami, K; Yoshida, S | 1 |
| Fasoli, MO; Kerridge, D; Morris, PG; Torosantucci, A | 1 |
| Martin, DS | 1 |
| Kemeny, NE; Martin, DS; Schneider, A | 1 |
| Chapekar, MS; Glazer, RI; Iigo, M | 1 |
| Klubes, P; Parker, WB | 1 |
| Boothman, DA; Briggle, TV; Greer, S | 2 |
| Kakuta, H; Kanamaru, R; Sato, T; Wakui, A | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY | 1 |
| Hardin, CC; Horowitz, J | 1 |
| Ho, DH; Kamiya, K; Nakamura, T; Sasaki, K; Tsutani, H; Uchida, M; Yoshimura, T | 1 |
| Klubes, P; Leyland-Jones, B | 1 |
| Darnowski, JW; Handschumacher, RE | 2 |
| Martin, DS; Sawyer, RC; Stolfi, RL | 1 |
| Nadal, JC; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Kusumoto, H; Kusumoto, T; Maehara, Y; Sakaguchi, Y; Sugimachi, K | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Blumenkranz, MS; Cheng, M; Dailey, WA; Hajek, AS; Hartzer, MK; Margherio, AR | 1 |
| Boothman, DA; Greer, SB; Mekras, JA | 1 |
| Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L | 2 |
| Heath, TD; Lewis, GP; Lopez, NG; Stern, WH | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 1 |
| Bollag, W; Hartmann, HR | 1 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, C | 1 |
| Blumenkranz, MS; Hajek, AS; Hartzer, MK | 1 |
| Aigner, KR; Danenberg, PV; Link, KH; Peschau, K; Schwemmle, K; Warthona, M | 1 |
| Laurensse, EJ; Peters, GJ; Pinedo, HM | 1 |
| Nakayama, C; Nishiyama, Y; Saneyoshi, M; Suzuki, S; Yoshida, S | 1 |
| Knaus, EE; Misra, HK; Suzuki, S; Tyrrell, DL; Wiebe, LI | 1 |
| Fasoli, M; Kerridge, D | 1 |
| Peters, GJ | 1 |
| Fujita, H; Furue, H; Hasegawa, K; Kurihara, M; Nakao, I; Niitani, H; Tsukagoshi, S | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Matsuzawa, T; Murakami, M | 1 |
| Lin, F; Warren, BS; Williams, WM | 1 |
| Colofiore, JR; Martin, DS; Stolfi, RL | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Nadal, JC; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, CJ | 1 |
| Benz, C; James, TL; Keniry, M; Shafer, RH | 1 |
| Chiba, Y; Okada, S; Tamemasa, O; Tezuka, M | 2 |
| Alderfer, JL; Loomis, RE | 1 |
| Kraal, I; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Brooks, M; Cadman, E; Tseng, A | 1 |
| O'Dea, RF; Ramnaraine, ML; Tuchman, M | 2 |
| Kennedy, KA; Klubes, P; Parker, WB | 1 |
| Fowke, LC; Rose, RJ; Setterfield, G | 1 |
| Goerttler, K; Kaufmann, M; Mattern, J; Volm, M; Wayss, K | 1 |
| Pitot, HC; Weiss, JW | 1 |
| Mattern, J; Volm, M; Wayss, K | 2 |
| Bean, B; Tomasz, A | 1 |
| Ryan, AM | 1 |
| Seidel, HJ; Wegner, LA | 1 |
| Jones, GH; Weissbach, H | 1 |
| Drouhet, E; Mercier-Soucy, L; Montplaisir, S | 1 |
| Beridze, TG; Cherkashina, NA; Odintsova, MS; Sissakian, NM | 1 |
| Wolberg, WH | 1 |
| Seeber, S; Warnecke, P; Weitzel, G | 1 |
| Kummer, D | 1 |
| Everson, R; Hall, TC; Kessel, D | 1 |
| Bruns, R; Hall, TC; Kessel, D | 1 |
| Beck, CF; Ingraham, JL; Neuhard, J; Thomassen, E | 1 |
| Williams, JP | 1 |
| Davis, WW; Garren, LD; Ney, RL | 1 |
| Dulbecco, R; Hatanaka, M | 1 |
| Pitot, HC; Wilkinson, DS | 1 |
| Goldblum, N; Manor, D | 1 |
| Chanock, RM; Gharpure, MA; Hodes, DS; Wright, PF | 1 |
| Chanock, RM; Hetrick, FM; Kalica, AR; Wright, PF | 1 |
| Kingsbury, DW; Marx, PA; Portner, A | 1 |
| Obijeski, JF; Simpson, RW | 1 |
| Dickson, JA; Suzangar, M | 1 |
| Duncan, IB; Pringle, CR; Stevenson, M | 1 |
| Bronchart, R; De Barsy, T; Deltour, R | 1 |
| Bullock, J; Khalil, FL; Lea, MA; Morris, HP | 1 |
| Clarkson, SG | 1 |
| Leaver, CJ; Lovett, JS | 1 |
| Krishnan, D; Painter, RB | 1 |
| Gerhart, JC; O'Donovan, GA | 1 |
| Kaiser, II | 1 |
| Belousova, AK; Meĭren, DV | 1 |
| Kulikowski, TK; Schugar, D | 1 |
| Endo, H; Hiroto, I; Koga, K; Komiyama, S; Kuwano, M | 1 |
| Klenk, HD; Kruczinna, R; Rott, R; Scholtissek, C | 1 |
| Bellett, AJ; Sambrook, JF; Tan, KB | 1 |
| Hedgcoth, C; Jacobson, M; Kaiser, II | 1 |
| Sköld, O | 1 |
| Ahmad, SI; Pritchard, RH | 1 |
| Hogg, L; Kemp, S; Wachsman, JT | 1 |
| Hogg, L; Wachsman, JT | 1 |
| Bloch, A; Fleysher, MH; Hall, RH; Maue, RJ; Thedford, R | 1 |
| Baranski, K; Bardos, TJ; Bloch, A; Kalman, TI | 1 |
| Applewhite, PB; Gardner, FT | 1 |
| Hand, RE; Tennant, RW | 1 |
| Oberhausen-Braun, H | 1 |
| Franke, HD | 1 |
| Guir, J; Obert, G; Tripier, F | 1 |
| Bardos, TJ; Burgess, GH; Klein, E; Schwartz, SH | 1 |
| Edlin, G; Neuhard, J | 1 |
| Hall, TC; Kessel, D; Reyes, P | 1 |
| Jund, R; Lacroute, F | 1 |
| Cain, JC; Merits, I | 1 |
| Soska, J; Sosková, L; Svoboda, A | 1 |
| McGuire, WL; O'Malley, BW | 1 |
| Bruce, WR; Madoc-Jones, H | 1 |
| Garvey, BI; Hayashi, TT | 1 |
| Hollomon, DW | 1 |
| Ebel, JP; Giege, R; Heinrich, J; Weil, JH | 1 |
| Bello, LJ; Ginsberg, HS | 1 |
| Burk, D; Woods, MW | 1 |
| Astaldi, G; Eridani, S; Giangrande, A; Ponti, GB; Valentini, R | 1 |
| Jordan, RL; Schumacher, H; Wilson, JG | 1 |
| Cailleau, R; Reeves, WJ | 1 |
| Thiry, L | 1 |
| Green, WR; Lis, AW | 1 |
| Ansfield, FJ; Gollin, FF; Vermund, H | 1 |
| Campisi, J; Pardee, AB | 1 |
| Gustavsson, B; Hafström, L | 1 |
| Cerna, I; Klubes, P; Meldon, MA | 1 |
| Fox, RM; Piper, AA | 1 |
| Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG | 1 |
| Cadman, E; Grant, S | 1 |
| Ardalan, B; Cooney, D; Lippman, M; Macdonald, J; Schein, P | 1 |
| Buxton, FP; Radford, A | 1 |
| Polak, A | 1 |
| Armstrong, RD; Connolly, KM; Diasio, RB; Kaplan, AM | 1 |
| Abe, Y; Endo, S; Fukuda, H; Ido, T; Ishiwata, K; Kubota, K; Matsuzawa, T; Sato, T; Takahashi, T; Yamada, K; Yoshioka, S | 1 |
| Ido, T; Ishiwata, K; Kawashima, K; Murakami, M; Takahashi, T | 1 |
| Hoshi, A; Iigo, M | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Matsuzawa, T; Monma, M; Takahashi, T; Tsurumi, Y | 1 |
| Gerok, W; Holstege, A; Keppler, D; Pausch, J | 1 |
| Teufel, G | 1 |
| Fujii, S; Shirasaka, T | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Fukuoka, K; Ishitsuka, H; Itoga, A; Maruyama, HB; Miwa, M; Takemoto, K | 1 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 2 |
| Hoshi, A; Kuretani, K; Yoshida, M | 1 |
| Heidelberger, C; Mulkins, MA | 1 |
| Gall, H; Kraal, I; Lankelma, J; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 2 |
| Dźwigaj-Stokłosa, W; Hołuj-Gubała, J; Pawlik, B | 1 |
| Hoshi, A; Iigo, M; Kuretani, K | 1 |
| Langen, P; Liermann, B; Matthes, E | 1 |
| Kraal, I; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Danenberg, PV; Shani, J | 1 |
| Benvenuto, J; Drewinko, B; Freireich, EJ; Ho, DH; Loo, TL; Yang, LY | 1 |
| Fujii, S; Fukushima, M; Ikenaka, K; Kitano, S; Maehara, Y; Nakamura, H; Shirasaka, T | 1 |
| Jellinghaus, W; Maurer, W; Müller, V; Schultze, B; Weis, G | 1 |
| Chikaraishi, Y; Tamemasa, O; Tezuka, M | 1 |
| Glazer, RI; Hartman, KD | 1 |
| Cerna, I; Klubes, P | 1 |
| Au, JL; Danhauser, L; Luccioni, C; Rustum, YM | 1 |
| Glazer, RI; Lloyd, LS | 1 |
| Tamemasa, O; Tezuka, M | 1 |
| Nissen, E; Tanneberger, S | 1 |
| Clement, JJ; Faucette, LF; Howard, WS; Johnson, RK; Wodinsky, I | 1 |
| Hopkins, HA; Looney, WB; Moore, JV | 1 |
| Filov, VA; Reztsova, VV; Stukov, AN | 1 |
| Howell, SB; Wung, WE | 1 |
| Barberi-Heyob, M; de Bruijn, EA; Dittrich, C; Guillemin, F; Luporsi, E; Merlin, JL; Weber, B | 1 |
| Allegra, CJ; Grogan, L; Sotos, GA | 1 |
| Buzaid, AC; Hait, WN; Marsh, JC; Murren, JR; Pizzorno, G; Poo, WJ; Ravikumar, TS; Strair, RK; Todd, M | 1 |
| Abdulmalek, S; McCarthy, CM; Montoya, DP | 1 |
| Hu, JL; Qi, CQ; Su, J; Zhen, YC | 1 |
| Allegra, CJ; Geoffroy, FJ; Grem, JL; Sinha, B | 1 |
| Inaba, M; Mitsuhashi, J | 1 |
| Doi, K; Itoh, H; Okada, S; Oku, N; Sakai, A; Shuto, S; Toyota, T | 1 |
| Chen, TB; Huzak, M; Macura, S; Vuk-Pavlović, S | 1 |
| Das, NP; Yit, CC | 1 |
| el Kouni, MH; el Kouni, MM; Naguib, FN | 1 |
| Blumenkranz, M; Hartzer, M; Lin, LR; Ward, T | 1 |
| Colofiore, J; Kemeny, N; Martin, D; Sawyer, R; Schneider, A; Seiter, K; Williams, L | 1 |
| Kitaichi, K; Koda, A; Mori, H; Sakamoto, O | 1 |
| Eda, H; Fujimoto, K; Ishikawa, T; Ishitsuka, H; Ohiwa, T; Tanaka, Y; Tatsuno, K; Watanabe, S | 1 |
| Bagrij, T; Kerpel-Fronius, S; Kiss, E; Kralovanszky, J; Peters, GJ; Prajda, N | 1 |
| Bertino, J; Casper, E; Christman, K; Colofiore, J; Kelsen, D; Martin, DS; Quan, V; Saltz, L; Schwartz, GK | 1 |
| Hickman, JA; Jackman, AL; Potten, CS; Pritchard, DM; Watson, AJ | 1 |
| Bertino, J; Kelsen, DP; Martin, D; O'Neil, J; Saltz, L; Schwartz, G; Sung, MT; von Borstel, R | 1 |
| Ishida, R; Ito, S; Koda, A; Mori, H; Nagai, H; Nakayama, K | 1 |
| Bertino, JR | 1 |
| Aida, M; Harada, K; Kajimoto, N; Maeda, M; Yamaizumi, J | 1 |
| Inaba, M; Mitsuhashi, J; Naoe, Y | 1 |
| Nakagawa, T; Sawai, Y; Yamaoka, K | 1 |
| Au, JL; Gan, Y; Song, D; Wientjes, MG | 1 |
| Bajzer, Z; Chen, TB; Macura, S; Vuk-Pavlovic, S | 1 |
| Erdélyi-Tóth, V; Jeney, A; Katona, C; Kovács, P; Kralovánszky, J; Noordhuis, P; Otvös, L; Pandi, E; Peters, GJ; Van der Wilt, CL | 1 |
| Campbell, E; Davidson, K; Diab, SG; Drengler, RL; Eckhardt, SG; Garner, AM; Hammond, LA; Hidalgo, M; Louie, A; O'Neil, JD; Rodriguez, G; Rowinsky, EK; Villalona-Calero, MA; von Borstel, R; Von Hoff, DD; Weiss, G | 1 |
| Al Safarjalani, ON; Ashour, OM; el Kouni, MH; Naguib, FN; Panzica, RP | 1 |
| Dorta, MJ; Llabrés, M; Munguía, O | 1 |
| Cao, D; Leffert, JJ; Pizzorno, G; Russell, RL; Zhang, D | 1 |
| Arbós, P; Campanero, MA; Irache, JM | 1 |
| Dorta, MJ; Fariña, JB; Llabrés, M; Munguía, O; Oliva, A | 1 |
| Cao, D; Handschumacher, RE; Leffert, JJ; Pizzorno, G; Russell, RL; Zhang, D | 1 |
| BOLAFFI, JL; CHEONG, L; EIDINOFF, ML; KNOLL, JE; RICH, MA | 1 |
| ERLANDSON, M; HARTMANN, JR; MURPHY, ML; ORIGENES, ML; SITARZ, A | 1 |
| BODMER, WF; GRETHER, S | 1 |
| HAHN, RG; MOERTEL, CG; REITEMEIER, RJ | 1 |
| BASCH, RS; KARNOFSKY, DA | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Agarwal, R; Ardalan, B; Patel, M | 1 |
| Cao, D; Pizzorno, G | 1 |
| Al Safarjalani, ON; El Kouni, MH; Naguib, FN; Rais, RH; Schinazi, RF; Shi, J; Zhou, XJ | 1 |
| Cao, D; Kim, B; Leffert, JJ; McCabe, J; Pizzorno, G | 1 |
| Saif, MW; von Borstel, R | 1 |
| Kemeny, NE; Leonard, GD | 1 |
| Al Safarjalani, ON; el Kouni, MH; Naguib, FN; Rais, R; Schinazi, RF; Shi, J | 1 |
| Magnier, M; Mulligan, RC; Stockwell, BR; Weissleder, R; Yen, L | 1 |
| Al-Salabi, MI; Candlish, D; de Koning, HP; Gudin, S; Jarvis, SM; Quashie, NB; Ranford-Cartwright, LC | 1 |
| Abbruzzese, JL; Cobb, PW; Doroshow, JH; Issell, BF; Macdonald, JS; McCoy, S; Patel, T; Yost, KJ | 1 |
| Fujimoto, S; Kihara, Y; Nagai, K; Nagasawa, K; Okuda, H | 1 |
| Engelbrecher, A; Häuser, R; Titz, B; Uetz, P | 1 |
| Beumer, JH; Doroshow, JH; Egorin, MJ; Lenz, HJ; Newman, EM; Parise, RA; Synold, TW | 1 |
| Besier, S; Brade, V; Dehghani, F; Loitsch, S; Saum, SH; Wichelhaus, TA; Zander, J | 1 |
| Codacci-Pisanelli, G; Noordhuis, P; Peters, GJ; van der Wilt, CL | 1 |
| Blanco-Bose, W; Bockamp, E; Dunant, CF; Eshkind, L; Jaworski, M; Laurenti, E; Lió, P; Macdonald, HR; Offner, S; Oser, G; Trumpp, A; van der Wath, RC; Wilson, A | 1 |
| Brody, JR; Costantino, CL; Eshleman, JR; Gallmeier, E; Hucl, T; Kern, SE; van der Heijden, MS; Wikiewicz, AK; Winter, JM; Yeo, CJ; Zhu, H | 1 |
| Banerjee, D; Bertino, JR; Humeniuk, R; Mishra, PJ | 1 |
| Castronovo, S; Roosild, TP | 1 |
| Akram, M; Balasubramanian, I; Bhattacharya, B; Dong, D; Fichtner, I; Iacopetta, B; Loh, M; Salto-Tellez, M; Soo, RA; Soong, R; Tan, WL; Thakkar, B; Wong, L | 1 |
| Goltz, D; Jauch, C; Schott, H; Schott, TC; Schwendener, RA | 1 |
| Doseth, B; Kavli, B; Krokan, HE; Pettersen, HS; Slupphaug, G; Svaasand, EK; Vågbø, CB; Visnes, T | 1 |
| Chen, M; Thelen, JJ | 1 |
| McEvilly, M; Popelas, C; Tremmel, B | 1 |
| Al Safarjalani, ON; el Kouni, MH; Naguib, FN; Rais, R | 1 |
| Ali, JA; Allison, HC; Burgess, K; Creek, DJ; De Koning, HP; Field, MC; Mäser, P | 1 |
| Basílio Janke, EM; Weisz, K | 1 |
| Baek, IH; Kim, MS; Kwon, KI; Lee, BY | 1 |
| Fairlamb, AH; Ong, HB; Patterson, S; Sienkiewicz, N; Wyllie, S | 1 |
| Accoceberry, I; Brèthes, D; Dementhon, K; El-Kirat-Chatel, S; Fitton-Ouhabi, V; Gabriel, F; Noël, T; Pujol, S; Sabra, A | 1 |
| Basso, LA; Campos, MM; Lopes, TG; Machado, P; Petersen, GO; Renck, D; Santos, AA; Santos, DS | 1 |
| Traynor, K | 1 |
| Fumoto, S; Miyamoto, H; Nishida, K; Shimokawa, K; Tomonaga, R; Utsunomiya, K; Wakasugi, K | 1 |
| Diasio, RB; Saif, MW | 1 |
| Bai, G; Beaver, JA; Charlab, R; Chen, XH; Cheng, J; Dinin, J; Dorff, SE; Ibrahim, A; Ison, G; Jin, R; Kim, G; Liu, Q; Marathe, A; McGuinn, WD; McKee, AE; Palmby, TR; Pazdur, R; Pierce, W; Sridhara, R; Stephens, O; Tang, S; Wang, Y; Ysern, X | 1 |
| Bamat, MK; Cartwright, TH; El-Rayes, BF; Fakih, MG; King, TR; Ma, WW; Posey, JA; Saif, MW; von Borstel, RW | 1 |
| Wilkinson, E | 1 |
| Galuski, K; Gil, B; Nugent, FW; Vaudo, CE; Zarwan, C | 1 |
| Geller, RJ; Morgan, BW; Santos, C | 1 |
| Aglietta, M; Bonzano, A; Cagnazzo, C; Depetris, I; Filippi, R; Leone, F; Marino, D | 1 |
| Bamat, MK; Garcia, RAG; Saydoff, JA; von Borstel, RW | 1 |
| Hussain, S | 1 |
| Brutcher, E; Christensen, D; Hennessey Smith, M; Koutlas, JB; Sellers, JB; Thompson, J; Timmons, T | 1 |
| Robert, J | 1 |
| Allison, C; Bachmann, D; Brown, F; Cao, Z; Doerflinger, M; Fernandez-Marrero, Y; Gangoda, L; Glab, J; Kaufmann, T; Ke, F; Kueh, A; Mathivanan, S; Menassa, J; Naim, S; Nedeva, C; Nelson, T; O'Reilly, L; Osellame, L; Puthalakath, H; Rabachini, T; Ramsay, R; Shahi, S; Smith, BJ; Srivastava, R; Wei, A | 1 |
| Carter, JM; Emmett, W; Helm, M; Hussain, S; Kotter, A; Mozos, IR; Ule, J | 1 |
| Montesdeoca-Esponda, S; Mordačíková, E; Santana-Rodríguez, JJ; Santana-Viera, S; Škvára, P; Vojs Staňová, A | 1 |
| Leung, M; Rogers, JE; Shureiqi, I | 1 |
| Callan, B; Callan, JF; Gao, J; Griffith, DM; Logan, KA; Love, M; McHale, AP; McKaig, T; Nesbitt, H; Taylor, M | 1 |
| Cho, JY; Jang, IJ; Jeon, I; Kang, J; Kim, AH; Lee, S; Oh, J | 1 |
17 review(s) available for uridine and fluorouracil
| Article | Year |
|---|---|
[Selective chemotherapy of hepatocellular carcinomas].
Topics: Animals; Carcinoma, Hepatocellular; Doxorubicin; Fluorouracil; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Orotic Acid; Rats; Uridine | 1978 |
Encapsulated filtering bleb. A selective review--new deductions.
Topics: Animals; Blister; Cicatrix; Conjunctival Diseases; Fibroblasts; Fluorouracil; Glaucoma; Humans; Postoperative Complications; Rabbits; Trabeculectomy; Uridine; Wound Healing | 1992 |
Modulation of fluorouracil toxicity with uridine.
Topics: Administration, Oral; Animals; Bone Marrow; Drug Administration Schedule; Fever; Fluorouracil; Humans; Mice; Uridine | 1992 |
Chemoprotectants for cancer chemotherapy.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Cisplatin; Cyclophosphamide; Fluorouracil; Humans; Ifosfamide; Leucovorin; Mesna; Methotrexate; Neoplasms; Razoxane; Sulfhydryl Compounds; Uridine | 1991 |
Enhancement of the antitumor activity of 5-fluorouracil by uridine rescue.
Topics: Animals; Drug Therapy, Combination; Fluorouracil; Humans; Neoplasms; Uridine | 1989 |
Enhancement of fluorouracil therapy by the manipulation of tissue uridine pools.
Topics: Animals; Fluorouracil; Humans; Uridine | 1989 |
Preclinical and clinical biochemical modulation of 5-fluorouracil by leucovorin and uridine.
Topics: Animals; Colorectal Neoplasms; Fluorouracil; Humans; Leucovorin; Mice; Tumor Cells, Cultured; Uridine | 1988 |
Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Culture Media; Drug Evaluation, Preclinical; Fluorouracil; Humans; Tegafur; Thymidine; Uridine | 1980 |
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Neoplasms; Neoplasms, Experimental; Thymidine; Thymidylate Synthase; Uridine | 1981 |
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colorectal Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Idoxuridine; Immunologic Factors; Interferons; Leucovorin; Methotrexate; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil; Uridine; Zidovudine | 1994 |
Chemotherapy of colorectal cancer: history and new themes.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; History, 20th Century; Humans; Prodrugs; Uridine | 1997 |
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.
Topics: Animals; Antineoplastic Agents; Biological Transport, Active; Fluorouracil; Gene Expression Regulation, Enzymologic; Genes, p53; Homeostasis; Humans; Neoplasms; Promoter Regions, Genetic; Subcellular Fractions; Uridine; Uridine Phosphorylase; Vimentin | 2002 |
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
Topics: Animals; Antimetabolites, Antineoplastic; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Neoplasms; Pyrimidines; Uridine; Uridine Phosphorylase | 2004 |
FDA Approval: Uridine Triacetate for the Treatment of Patients Following Fluorouracil or Capecitabine Overdose or Exhibiting Early-Onset Severe Toxicities Following Administration of These Drugs.
Topics: Acetates; Animals; Antineoplastic Agents; Capecitabine; Clinical Trials as Topic; Drug Approval; Drug Evaluation, Preclinical; Fluorouracil; Humans; Neoplasms; Prescription Drug Overuse; Research Design; Treatment Outcome; United States; United States Food and Drug Administration; Uridine | 2016 |
Fluoropyrimidine-induced cardiotoxicity.
Topics: Acetates; Capecitabine; Cardiotoxicity; Cardiovascular Diseases; Drug Combinations; Fluorouracil; Humans; Neoplasms; Pyrimidines; Pyrrolidines; Quinazolines; Thiophenes; Thymine; Trifluridine; Uracil; Uridine | 2018 |
Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications.
Topics: Animals; Azacitidine; Biocatalysis; Cross-Linking Reagents; Escherichia coli Proteins; Fluorouracil; Humans; Immunoprecipitation; Methylation; Methyltransferases; Multienzyme Complexes; Pseudouridine; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome; Uridine | 2019 |
5-Fluorouracil and Capecitabine: Assessment and Treatment of Uncommon Early-Onset Severe Toxicities Associated With Administration.
Topics: Acetates; Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Patient Safety; Risk Assessment; Severity of Illness Index; Survival Analysis; Uridine | 2018 |
7 trial(s) available for uridine and fluorouracil
| Article | Year |
|---|---|
Biochemical modulation of 5-fluorouracil with brequinar: results of a phase I study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Drug Administration Schedule; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Uridine | 1995 |
A phase I trial of a modified, dose intensive FAMTX regimen (high dose 5-fluorouracil+doxorubicin+high dose methotrexate+leucovorin) with oral uridine rescue.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Female; Fluorouracil; Humans; Leucovorin; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasms; Neutropenia; Uridine | 1996 |
Phase I trial of PN401, an oral prodrug of uridine, to prevent toxicity from fluorouracil in patients with advanced cancer.
Topics: Acetates; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Prodrugs; Uridine | 1997 |
Phase I and pharmacologic study of PN401 and fluorouracil in patients with advanced solid malignancies.
Topics: Acetates; Adult; Antimetabolites, Antineoplastic; Cytoprotection; Diarrhea; Dose-Response Relationship, Drug; Female; Fluorouracil; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Neutropenia; Prodrugs; Statistics, Nonparametric; Uridine | 2000 |
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: a Southwest Oncology Group study.
Topics: Acetates; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Stomach Neoplasms; Survival Analysis; Uridine | 2006 |
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Deoxycytidine; DNA Modification Methylases; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrouridine; Uridine | 2008 |
275 other study(ies) available for uridine and fluorouracil
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
[Sensitivity tests of malignant tumours against cytostatic agents in vitro and in vivo/studies on the mouse sarcoma 180 (author's transl)].
Topics: Animals; Antineoplastic Agents; Biological Transport; Bleomycin; Cell Membrane Permeability; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Fluorouracil; Methotrexate; Mice; Mice, Inbred Strains; Podophyllin; Sarcoma 180; Uridine | 1975 |
Sensitivity tests of tumors to cytostatic agents. I. Comparative investigations on transplanted tumors in vivo and in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cell Division; Cricetinae; Dactinomycin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Fluorouracil; In Vitro Techniques; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Neoplasms, Experimental; Plasmacytoma; Procarbazine; Rats; Rats, Inbred ACI; Sarcoma 180; Thymidine; Triaziquone; Uridine | 1975 |
Sensitivity tests of tumors to cytostatic agents. II. Investigation on human tumors.
Topics: Antineoplastic Agents; Autoradiography; Breast Neoplasms; Cell Count; Cell Division; Culture Techniques; Dactinomycin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Lung Neoplasms; Neoplasms; Nucleic Acids; Ovarian Neoplasms; Procarbazine; Uridine | 1975 |
Toxoplasma gondii: characterization of a mutant resistant to 5-fluorodeoxyuridine.
Topics: Animals; Cell Line; Deoxyuridine; DNA; Drug Resistance; Floxuridine; Fluorouracil; Genes; Mutation; RNA; Thymidine; Toxoplasma; Uridine | 1977 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine | 1979 |
Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine.
Topics: Animals; Body Weight; Digestive System; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Lethal Dose 50; Male; Mice; Mice, Inbred CBA; RNA; Time Factors; Uridine | 1979 |
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Chromatography, High Pressure Liquid; Deoxyuridine; Floxuridine; Fluorouracil; Kinetics; Mice; Thymidine; Uridine | 1979 |
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Floxuridine; Fluorouracil; In Vitro Techniques; Liver Neoplasms; Neoplasms, Experimental; RNA, Neoplasm; RNA, Ribosomal; Time Factors; Uridine | 1975 |
In vitro effect of LH-RH on RNA content and synthesis in isolated anterior pituitary cells from intact and castrated female rats.
Topics: Animals; Castration; DNA; Estradiol; Female; Fluorouracil; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; Pituitary Gland, Anterior; Rats; RNA; Uridine | 1978 |
Apparent involvement of purines in the control of expression of Salmonella typhimurium pyr genes: analysis of a leaky guaB mutant resistant to pyrimidine analogs.
Topics: Drug Resistance, Microbial; Fluorouracil; Guanine Nucleotides; IMP Dehydrogenase; Ketone Oxidoreductases; Mutation; Purine Nucleotides; Pyrimidines; Salmonella typhimurium; Uridine | 1979 |
The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro.
Topics: Animals; Cell Nucleus; Fluorouracil; In Vitro Techniques; Leukemia L1210; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Poly A; RNA, Neoplasm; Uridine | 1979 |
Specific inhibition of transfer RNA methylation and modification in tissues of mice treated with 5-fluorouracil.
Topics: Animals; Female; Fluorouracil; In Vitro Techniques; Liver; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylation; Mice; Mice, Inbred BALB C; Pseudouridine; RNA, Neoplasm; RNA, Transfer; tRNA Methyltransferases; Uridine | 1978 |
Effect of 5-fluorouracil and 5-fluorouridine on metaphase chromosome structure in human lymphoid cells.
Topics: Antineoplastic Agents; Cell Cycle; Chromosomes, Human; Fluorouracil; Humans; Lymphocytes; Metaphase; Uridine | 1978 |
In vivo transcription of the spacer sequences of rDNA in Xenopus.
Topics: Animals; Anura; Base Sequence; Cell Line; Culture Techniques; DNA; Female; Fluorouracil; Nucleic Acid Hybridization; Oocytes; Ovum; RNA, Ribosomal; Transcription, Genetic; Uridine; Xenopus | 1977 |
The ribosomes of Drosophila. Normal and defective ribosome biosynthesis in Drosophila cell cultures.
Topics: Adenosine; Cell Line; Cell Nucleolus; Cycloheximide; Drosophila; Fluorouracil; In Vitro Techniques; Ribosomal Proteins; Ribosomes; RNA, Ribosomal; Uridine | 1977 |
Kinetic aids to proper chemotherapeutic scheduling: labeled nucleoside incorporation studies in vivo.
Topics: Animals; Bone Marrow; Cell Survival; Cyclophosphamide; DNA, Neoplasm; Drug Administration Schedule; Fluorouracil; Granulocytes; Intestinal Mucosa; Kinetics; Lomustine; Male; Melanoma; Methotrexate; Mice; Neoplasms, Experimental; Pyrimidine Nucleosides; Thymidine; Uridine | 1976 |
Effect of cytostatic drugs on nucleic acid synthesis in mouse thymocytes and chick embryo cells.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytarabine; Dactinomycin; Deoxyadenosines; Deoxyuridine; DNA; Fluorouracil; Melphalan; Methotrexate; Mice; Mice, Inbred Strains; Thymidine; Thymus Gland; Triaziquone; Tritium; Uridine; Vinblastine | 1975 |
Further isolation and characterization of temperature-sensitive mutants of influenza virus.
Topics: Animals; Cattle; Cell Line; Crosses, Genetic; Cytopathogenic Effect, Viral; Dactinomycin; Fluorouracil; Genetic Complementation Test; Hemagglutinins, Viral; Hydroxylamines; Kidney; Mutagens; Mutation; Neuraminidase; Orthomyxoviridae; Recombination, Genetic; RNA, Viral; Temperature; Tritium; Uridine; Viral Plaque Assay; Viral Proteins | 1975 |
Oligonucleotide conformations. III. Comparative optical and thermodynamic studies of uridylyl-3'-5'-nucleosides containing ribose, deoxyribose, or 2'-deoxy-2'-fluororibose in the uridine moiety.
Topics: Circular Dichroism; Deoxyribonucleosides; Fluorouracil; Oligonucleotides; Ribonucleosides; Structure-Activity Relationship; Thermodynamics; Uridine | 1975 |
The effect of cytostatic drugs on the synthesis of DNA in adenocarcinomas of the stomach. An in vitro study.
Topics: Adenocarcinoma; Antineoplastic Agents; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Humans; In Vitro Techniques; Melphalan; Methotrexate; Stomach Neoplasms; Thymidine; Tritium; Uridine; Vinblastine | 1975 |
Effect of cytochalasin-B on the transport of 5-fluorouracil in cultured mammalian cells.
Topics: Cell Membrane Permeability; Cells, Cultured; Cytochalasin B; Fluorouracil; Glucosamine; Leucine; Uridine | 1975 |
Effect of N1-(2'-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on nucleic acid and protein biosyntheses in Ehrlich ascites cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; DNA, Neoplasm; Fluorouracil; Furans; Liver; Male; Mice; Neoplasm Proteins; Neoplasms, Experimental; RNA, Neoplasm; Time Factors; Uridine | 1976 |
Mechanisms of collateral sensitivity to fluorouracil of a cis-diamminedichloroplatinum(II)-resistant human non-small lung cancer cell line.
Topics: Adenocarcinoma; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cisplatin; DNA Damage; Drug Resistance; Fluorouracil; Humans; In Vitro Techniques; Lung Neoplasms; RNA, Neoplasm; Thymine Nucleotides; Tumor Cells, Cultured; Uridine | 1992 |
Biochemical modulation of 5-fluorouracil with leucovorin or delayed uridine rescue. Correlation of antitumor activity with dosage and FUra incorporation into RNA.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Dose-Response Relationship, Drug; Fluorouracil; Leucovorin; Mammary Neoplasms, Experimental; Mice; RNA; Thymidylate Synthase; Time Factors; Uridine | 1992 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L1210; Leukemia P388; Lung Neoplasms; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Organ Size; Sarcoma 180; Spleen; Tegafur; Thymus Gland; Uridine | 1992 |
Novel derivatives of 5-fluorouridine and 5-fluorouracil having potent antitumor and lower immunosuppressive activities.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Cell Division; Fluorouracil; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Organ Size; RNA, Ribosomal; Thymus Gland; Tumor Cells, Cultured; Uridine | 1992 |
Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Phosphates; Potassium; Potassium Compounds; Spectrophotometry, Ultraviolet; Uridine | 1992 |
Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Colonic Neoplasms; Digestive System; Drug Synergism; Female; Fluorouracil; Kidney; Kinetics; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Spleen; Thymidylate Synthase; Uracil Nucleotides; Uridine | 1992 |
Effects of fluorouracil and fluorouridine on protein synthesis in rabbit retina.
Topics: Animals; Autoradiography; Axonal Transport; Conjunctiva; Eye Proteins; Fluorouracil; Photoreceptor Cells; Rabbits; Retina; Retinal Ganglion Cells; Rod Cell Outer Segment; Uridine; Vitreous Body | 1990 |
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
Loss of murine tumor thymidine kinase activity in vivo following 5-fluorouracil (FUra) treatment by incorporation of FUra into RNA.
Topics: Animals; DNA; Dose-Response Relationship, Drug; Fluorouracil; Mammary Neoplasms, Experimental; Methotrexate; Mice; Ornithine Decarboxylase; RNA; Thymidine Kinase; Thymidylate Synthase; Tritium; Uridine | 1991 |
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Drug Screening Assays, Antitumor; Female; Fluorouracil; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Tumor Cells, Cultured; Uridine | 1992 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Thymidine Phosphorylase; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice.
Topics: Animals; Circadian Rhythm; Female; Floxuridine; Fluorouracil; Liver; Male; Mice; Uridine; Uridine Phosphorylase | 1990 |
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
Topics: Chromatography, High Pressure Liquid; Coumarins; Floxuridine; Fluorine; Fluorouracil; Humans; Molecular Structure; Pyrimidines; Tegafur; Umbelliferones; Uridine | 1990 |
19F nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of Candida glabrata with specific defects in pyrimidine metabolism.
Topics: Candida; Cells, Cultured; Cytosine Deaminase; Flucytosine; Fluorouracil; Magnetic Resonance Spectroscopy; Nucleoside Deaminases; Pentosyltransferases; Phenotype; RNA, Ribosomal; Uridine; Uridine Kinase | 1990 |
Introduction to 5-fluorouracil modulation.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Drug Interactions; Fluorouracil; Humans; Leucovorin; Methotrexate; Phosphonoacetic Acid; Uridine | 1990 |
Phase I trial of PALA, methotrexate, fluorouracil, leucovorin, and uridine rescue in patients with advanced cancer. The use of uridine to decrease fluorouracil toxicity.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Drug Evaluation; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Neoplasms; Phosphonoacetic Acid; Uridine | 1990 |
Synergistic antitumor effect of fluoropyrimidines and polyinosinic-polycytidylic acid against L1210 leukemia.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Drug Synergism; Fluorouracil; Interferons; Leukemia L1210; Mice; Mice, Inbred Strains; Poly I-C; RNA; Uridine | 1985 |
Enhancement by uridine of the anabolism of 5-fluorouracil in mouse T-lymphoma (S-49) cells.
Topics: Animals; Cell Survival; Cells, Cultured; DNA; Fluorouracil; Lymphoma; Mice; Phosphoribosyl Pyrophosphate; Protein Biosynthesis; Pyrimidines; RNA; T-Lymphocytes; Tritium; Uridine; Uridine Triphosphate | 1985 |
Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755.
Topics: Animals; Antimetabolites; Chromatography, High Pressure Liquid; Cytidine Deaminase; DCMP Deaminase; Deoxycytidine; DNA; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; RNA; Tetrahydrouridine; Uridine | 1987 |
Mechanisms of action of 5-fluorouracil on metabolism of RNA in special reference to polysome of L1210 cells.
Topics: Animals; Cell Line; Fluorouracil; Leukemia L1210; Mice; Polyribosomes; Ribosomes; RNA; Tritium; Uridine | 1986 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Messenger; RNA, Ribosomal; Sarcoma 180; Uridine | 1987 |
Mobility of individual 5-fluorouridine residues in 5-fluorouracil-substituted Escherichia coli valine transfer RNA. A 19F nuclear magnetic resonance relaxation study.
Topics: Chemical Phenomena; Chemistry, Physical; Escherichia coli; Fluorouracil; Magnetic Resonance Spectroscopy; RNA, Bacterial; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Val; Uridine | 1987 |
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia L1210; Mice; Tumor Cells, Cultured; Uridine | 1989 |
Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Disease Models, Animal; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Pentosyltransferases; Uracil; Uridine; Uridine Phosphorylase | 1989 |
Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma.
Topics: Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hematologic Diseases; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Uridine | 1989 |
Species differences in substrate specificity of pyrimidine nucleoside phosphorylase.
Topics: Animals; Colon; Deoxyuridine; Digestive System; Digestive System Neoplasms; Fluorouracil; Humans; Liver; Mice; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rectum; Species Specificity; Stomach; Substrate Specificity; Thymidine; Uridine | 1989 |
Reversal of 5-fluorouracil-induced myelosuppression by prolonged administration of high-dose uridine.
Topics: Aged; Bone Marrow; Female; Fluorouracil; Humans; Leukopenia; Male; Middle Aged; Neoplasms; Thrombocytopenia; Uridine | 1989 |
Selection of therapeutic agents for intraocular proliferative disease 3. Effects of fluoropyrimidines on cell-mediated contraction of human fibroblasts.
Topics: Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Fibroblasts; Fluorouracil; Gels; Humans; Sclera; Uridine | 1989 |
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Cytidine Deaminase; Deoxycytidine; DNA; Female; Floxuridine; Fluorouracil; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Nucleoside Deaminases; Tetrahydrouridine; Thymidylate Synthase; Trifluridine; Uridine | 1985 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; Rectal Neoplasms; Uridine | 1986 |
Fluoropyrimidine treatment of ocular cicatricial disease.
Topics: Animals; Cell Division; Cicatrix; Eye Diseases; Fibroblasts; Floxuridine; Fluorouracil; Osmolar Concentration; Rabbits; Skin; Uridine | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung Neoplasms; Male; Mice; Rats; Rats, Inbred Strains; Sarcoma 180; Thymidine; Uridine | 1986 |
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Topics: Animals; Body Temperature Regulation; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Hematopoiesis; Leukocyte Count; Mice; Uridine | 1986 |
Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eye Neoplasms; Floxuridine; Flucytosine; Fluorouracil; Humans; Uridine | 1987 |
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
Topics: Animals; Antimetabolites; Deoxycytidine; Female; Floxuridine; Fluorouracil; Lung Neoplasms; Mice; Tetrahydrouridine; Uridine | 1987 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Rectal Neoplasms; Uridine | 1987 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Rectal Neoplasms; Time Factors; Tumor Cells, Cultured; Uridine | 1988 |
A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography.
Topics: Cell Line, Transformed; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Kinetics; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured; Uracil; Uridine | 1988 |
Mechanism of selective inhibition of human cytomegalovirus replication by 1-beta-D-arabinofuranosyl-5-fluorouracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Arabinonucleotides; Cytomegalovirus; DNA-Directed DNA Polymerase; Fluorouracil; Kinetics; Nucleic Acid Synthesis Inhibitors; Structure-Activity Relationship; Thymine Nucleotides; Uridine; Virus Replication | 1985 |
A proposed mechanism for the selective inhibition of human cytomegalovirus replication by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-fluorouracil.
Topics: Antiviral Agents; Arabinofuranosyluracil; Arabinonucleosides; Arabinonucleotides; Cell Line; Cell Survival; Cytomegalovirus; Fluorouracil; Nucleic Acid Synthesis Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Uridine; Viral Plaque Assay; Virus Replication | 1987 |
Isolation and characterization of fluoropyrimidine-resistant mutants in two Candida species.
Topics: Candida; Candida albicans; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Mutation; Phenotype; Uridine | 1988 |
[FO-152].
Topics: Absorption; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Dogs; Drug Evaluation; Female; Fluorouracil; Humans; Leukemia L1210; Lung Neoplasms; Male; Mice; Stomach Neoplasms; Tegafur; Uridine | 1987 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimidines; Radionuclide Imaging; Rats; Thymidine; Tissue Distribution; Tritium; Uridine | 1985 |
Gas-liquid chromatographic analysis of fluoropyrimidine nucleosides and fluorouracil in plasma and urine.
Topics: Animals; Chromatography, Gas; Chromatography, Ion Exchange; Dogs; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kidney; Kinetics; Uridine | 1985 |
Failure of high-dose leucovorin to improve therapy with the maximally tolerated dose of 5-fluorouracil: a murine study with clinical relevance?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Leucovorin; Mice; Neoplasms, Experimental; Uridine | 1988 |
In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.
Topics: Animals; Bone Marrow; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Intestinal Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Tumor Cells, Cultured; Uridine | 1988 |
Noninvasive spectroscopic analysis of fluoropyrimidine metabolism in cultured tumor cells.
Topics: Animals; Cells, Cultured; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Magnetic Resonance Spectroscopy; Mice; Monitoring, Physiologic; Neoplasms; Sarcoma 180; Uridine | 1986 |
Mechanisms of potentiation of antitumor activity of 5-fluorouracil by ribothymidine in a mouse tumor system.
Topics: Animals; Carcinoma, Ehrlich Tumor; Drug Synergism; Fluorouracil; In Vitro Techniques; Liver; Male; Mice; Uridine; Uridine Kinase; Uridine Phosphorylase | 1986 |
Halogenated nucleic acids: effects of 5-fluorouracil on the conformation and properties of a polyribonucleotide and its constituents.
Topics: Fluorouracil; Molecular Conformation; Nucleic Acid Conformation; Poly U; Polydeoxyribonucleotides; Uracil Nucleotides; Uridine | 1986 |
Clinical and pharmacokinetic studies of prolonged administration of high-dose uridine intended for rescue from 5-FU toxicity.
Topics: Aged; Body Temperature; Drug Administration Schedule; Female; Fluorouracil; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Neoplasms; Uracil; Uridine | 1986 |
Modulation of fluoropyrimidine metabolism by chlorpromazine.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cell Survival; Chlorpromazine; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Kinetics; Mice; Sarcoma, Experimental; Tritium; Uridine | 1986 |
In vitro degradation of pyrimidine bases: studies of rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1986 |
Enhancement of antitumor activity of 5-fluorouracil by ribothymidine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Drug Synergism; Fluorouracil; Leukemia P388; Male; Mice; Mice, Inbred Strains; Uridine | 1986 |
Dissociation of 5-fluorouracil-induced DNA fragmentation from either its incorporation into DNA or its cytotoxicity in murine T-lymphoma (S-49) cells.
Topics: Animals; Cell Survival; Chromatography, High Pressure Liquid; Colony-Forming Units Assay; Crotalid Venoms; Deoxyribonuclease I; DNA; Fluorouracil; Lymphoma; Mice; Thymidine; Uridine | 1987 |
Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine.
Topics: Animals; Colonic Neoplasms; Female; Fluorouracil; Lethal Dose 50; Mice; Mice, Inbred C57BL; Uracil; Uridine | 1985 |
Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase.
Topics: Animals; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Kinetics; Liver; Oxidoreductases; Rats; Rats, Inbred Strains; Thymidine; Thymine; Uracil; Uridine | 1985 |
Activation of nucleoli in tuber slices and the function of nucleolar vacuoles.
Topics: Autoradiography; Cell Nucleolus; Cytoplasm; Fluorouracil; Histocytochemistry; Inclusion Bodies; Methods; Microscopy, Electron; Microscopy, Interference; Plants; Ribonucleases; RNA; Staining and Labeling; Time Factors; Tritium; Uridine | 1972 |
[Selective tumour chemotherapy using oncobiograms (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cricetinae; Culture Techniques; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation; Drug Resistance; Fluorouracil; Humans; Methods; Methotrexate; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Procarbazine; Radioisotopes; Rats; Scintillation Counting; Thymidine; Triaziquone; Uridine | 1974 |
Inhibition of ribosomal ribonucleic acid maturation by 5-azacytidine and 8-azaguanine in Novikoff hepatoma cells.
Topics: Animals; Azacitidine; Azaguanine; Carcinoma, Hepatocellular; Cells, Cultured; Cytidine; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Guanosine; Isotope Labeling; Liver; Liver Neoplasms; Neoplasms, Experimental; Rats; RNA, Neoplasm; RNA, Ribosomal; Spectrophotometry, Ultraviolet; Time Factors; Tritium; Uridine | 1974 |
[The effects of cytostatic agents on short-term cultures (3H-uridine incorporation) and tissue cultures (cell counts) from human tumors (author's transl)].
Topics: Antineoplastic Agents; Bleomycin; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Drug Evaluation, Preclinical; Female; Fluorouracil; Humans; In Vitro Techniques; Methods; Methotrexate; Neoplasms; Ovarian Neoplasms; Podophyllin; Suspensions; Time Factors; Triaziquone; Tritium; Uridine | 1974 |
5-Fluoropyrimidine-resistant mutants of pneumococcus.
Topics: Carbon Isotopes; Chromatography, Thin Layer; Cytosine; Deoxyribonucleosides; Drug Resistance, Microbial; Floxuridine; Fluorine; Fluorouracil; Mutation; N-Glycosyl Hydrolases; Pentosyltransferases; Phosphoric Monoester Hydrolases; Phosphotransferases; Pyrimidines; Ribonucleosides; Streptococcus pneumoniae; Transformation, Genetic; Uridine | 1973 |
Cross-induction of Escherichia coli lysogens by an ultraviolet irradiation product. I. The dispensability of concurrent macromolecular syntheses in the formation of a metabolically unstable inducer.
Topics: Chloramphenicol; Coliphages; Conjugation, Genetic; Dactinomycin; DNA, Bacterial; Edetic Acid; Escherichia coli; Fluorouracil; Lysogeny; Macromolecular Substances; Molecular Biology; Mutation; Puromycin; Radiation Genetics; RNA, Bacterial; Tryptophan; Ultraviolet Rays; Uracil; Uridine | 1967 |
[Estimation of tumor sensitivity in vitro. I. Comparative studies with the Jensen sarcoma in vivo and in vitro after 1-hour-incubation].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Autoradiography; Cycloparaffins; Dactinomycin; DNA, Neoplasm; Fluorouracil; In Vitro Techniques; Methods; Methotrexate; Mustard Compounds; Neoplasm Transplantation; Nucleosides; Rats; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Time Factors; Triaziquone; Tritium; Uridine; Vinblastine | 1969 |
RNA metabolism in Streptomyces antibioticus; effect of 5-fluorouracil on the appearance of phenoxazinone synthetase.
Topics: Amino Acids; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Chromatography; Dactinomycin; Fluorouracil; ortho-Aminobenzoates; Oxazines; Oxidoreductases; Proline; RNA, Bacterial; RNA, Transfer; Serine; Streptomyces; Time Factors; Tritium; Uridine | 1970 |
[Sensitivity and resistance of Candida to 5-fluorocytosine, 5-fluorouracil and 5-fluorouridine. Relation to the ecology and serotype of C. albicans].
Topics: Africa; Antifungal Agents; Candida; Candida albicans; Cytosine; Drug Resistance, Microbial; Europe; Flucytosine; Fluorouracil; Humans; Microbial Sensitivity Tests; Phenotype; Serotyping; Statistics as Topic; Uridine | 1974 |
The effect of nucleic acid synthesis inhibitors on the chlorophyll formation by etiolated bean leaves.
Topics: Azaguanine; Chlorophyll; Dactinomycin; Floxuridine; Fluorouracil; In Vitro Techniques; Mitomycins; Plants, Edible; Thiouracil; Thymidine; Uridine | 1966 |
Determinants of human tumor sensitivity to fluorinated pyrimidine chemotherapy.
Topics: DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Ligases; Neoplasm Metastasis; Neoplasms; Phosphotransferases; Thymidine; Thymidine Kinase; Uracil Nucleotides; Uridine | 1967 |
[Comparative in vitro studies with 5-fluorouracil and some of its derivatives].
Topics: Acyltransferases; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Depression, Chemical; DNA Nucleotidyltransferases; DNA, Neoplasm; Floxuridine; Fluorine; Fluorouracil; In Vitro Techniques; Leucine; Neoplasm Proteins; Nucleotides; RNA, Neoplasm; Thymidine; Uridine | 1969 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Plasmacytoma; Thymidine Kinase; Transferases; Uridine | 1970 |
Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias.
Topics: Animals; Antineoplastic Agents; Biodegradation, Environmental; Biological Transport; Cell Line; Cell Survival; Cells, Cultured; Deoxyuridine; DNA Replication; DNA, Neoplasm; Drug Resistance; Floxuridine; Fluorine; Fluorouracil; Leukemia, Experimental; Mice; Neoplasm Transplantation; Pentosyltransferases; Phosphotransferases; Uridine | 1971 |
Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.
Topics: Aminohydrolases; Cytidine; Cytosine; Deoxyuridine; Floxuridine; Flucytosine; Fluorouracil; Genetics, Microbial; Genotype; Mutation; Nucleosides; Nucleotidyltransferases; Pentosyltransferases; Phosphotransferases; Pyrimidines; Salmonella typhimurium; Thymidine; Uracil; Uracil Nucleotides; Uridine | 1972 |
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Floxuridine; Fluorine; Fluorouracil; Mice; Mice, Inbred Strains; Pregnancy; Rats; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Heterogeneity of templae RNA in adrenal glands.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Corticosterone; Dactinomycin; Fluorouracil; Hypophysectomy; Rats; RNA; Uridine | 1966 |
SV 40-specific thymidine kinase.
Topics: Animals; Culture Techniques; Cytopathogenic Effect, Viral; DNA Nucleotidyltransferases; Fluorouracil; Haplorhini; Hot Temperature; Kinetics; Simian virus 40; Thymidine Kinase; Uridine; Virulence | 1967 |
Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Electrophoresis; Fluorine; Fluorouracil; Kinetics; Liver Neoplasms; Methionine; Methylation; Neoplasms, Experimental; Rats; RNA, Ribosomal; Tritium; Uracil; Uridine | 1973 |
Isolation and partial characterization of temperature-sensitive mutants of the SAT-1 strain of foot-and-mouth disease virus.
Topics: Animals; Aphthovirus; Cricetinae; Fluorouracil; Guinea Pigs; Hydroxylamines; Kidney; Kinetics; Mice; Mutation; Phenotype; RNA, Viral; Temperature; Tritium; Uridine | 1973 |
Genetic studies of respiratory syncytial virus temperature-sensitive mutants.
Topics: Alkanesulfonates; Carcinoma; Cell Line; Crosses, Genetic; Fluorine; Fluorouracil; Genetic Complementation Test; Genetics, Microbial; HeLa Cells; Heterozygote; Humans; Laryngeal Neoplasms; Mutagens; Mutation; Recombination, Genetic; Respiratory Syncytial Viruses; Temperature; Uridine; Virus Replication | 1973 |
Electron microscopic studies of respiratory syncytial temperature-sensitive mutants.
Topics: Alkanesulfonates; Antigens, Viral; Cell Membrane; Cytopathogenic Effect, Viral; Cytoplasm; Fluorescent Antibody Technique; Fluorine; Fluorouracil; Genetic Complementation Test; Genetics, Microbial; HeLa Cells; Humans; Inclusion Bodies, Viral; Microscopy, Electron; Morphogenesis; Mutagens; Mutation; Respiratory Syncytial Viruses; Temperature; Uridine; Virus Replication | 1973 |
Isolation and characterization of Sendai virus temperature-sensitive mutants.
Topics: Animals; Centrifugation, Zonal; Chick Embryo; Culture Techniques; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Genetic Complementation Test; Glycoproteins; Hemagglutinins, Viral; Lung; Mutagens; Mutation; Neuraminidase; Nitrosoguanidines; Parainfluenza Virus 1, Human; RNA, Viral; Temperature; Tritium; Uridine; Viral Proteins; Virus Replication | 1974 |
Conditional lethal mutants of vesicular stomatitis virus. I. Phenotypic characterization of single and double mutants exhibiting host restriction and temperature sensitivity.
Topics: Animals; Carcinoma; Cell Line; Cell-Free System; Chick Embryo; Culture Techniques; Dactinomycin; DNA-Directed RNA Polymerases; Fibroblasts; Fluorouracil; HeLa Cells; Humans; Laryngeal Neoplasms; Mutagens; Mutation; Nitrosoguanidines; Phenotype; RNA, Viral; Temperature; Tritium; Uridine; Vesicular stomatitis Indiana virus; Viral Plaque Assay; Virus Replication | 1974 |
In vitro-in vivo studies on the susceptibility of the solid Yoshida sarcoma to drugs and hyperthermia (42 degrees).
Topics: Animals; Antineoplastic Agents; Carbon Dioxide; Carbon Radioisotopes; Cell Survival; Cells, Cultured; Cyclophosphamide; Dactinomycin; Fluorouracil; Glycolysis; Hot Temperature; Leucine; Mesylates; Oxygen Consumption; Rats; Sarcoma, Yoshida; Thymidine; Time Factors; Uridine; Vinblastine | 1974 |
Isolation and characterization of temperature-sensitive mutants of vesicular stomatitis virus, New Jersey serotype.
Topics: Animals; Cell Line; Cricetinae; Dactinomycin; Fluorouracil; Genetic Complementation Test; Kidney; Mutagens; Mutation; RNA, Viral; Serotyping; Temperature; Tritium; Uridine; Vesicular stomatitis Indiana virus; Vesiculovirus | 1971 |
Study of nucleolar vacuolation and RNA synthesis in embryonic root cells of Zea mays.
Topics: Autoradiography; Cell Nucleolus; Dactinomycin; Fluorouracil; Inclusion Bodies; Microscopy, Electron; Plants; RNA, Ribosomal; Temperature; Thiouracil; Tritium; Uridine; Zea mays | 1974 |
Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Fluorouracil; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Liver Neoplasms; Liver Regeneration; Male; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; Phosphates; Rats; RNA, Neoplasm; Schistosomicides; Thioxanthenes; Thymidine; Time Factors; Transplantation, Homologous; Tritium; Uracil; Uridine | 1974 |
Nucleic acid and protein synthesis and pattern regulation in hydra. II. Effect of inhibition of nucleic acid and protein synthesis on hypostome formation.
Topics: Animals; Chloramphenicol; Cnidaria; Cytosine; Dactinomycin; DNA; Fluorouracil; Hydroxyurea; Morphogenesis; Protein Biosynthesis; RNA; RNA, Messenger; Thymidine; Transplantation; Tritium; Uridine | 1969 |
An analysis of protein and RNA synthesis during encystment and outgrowth (germination) of Blastocladiella zoospores.
Topics: Buffers; Carbon Radioisotopes; Centrifugation, Density Gradient; Culture Media; Cycloheximide; Dactinomycin; Fluorouracil; Fungal Proteins; Fungi; Leucine; Methods; Microscopy, Electron; Polyribosomes; Ribosomes; RNA; RNA, Messenger; RNA, Ribosomal; Spores, Fungal; Tritium; Uridine | 1974 |
An anomalous effect of hydroxyurea and visible light on nucleic acids of a photoreactivating mammalian cell Potorous tridactylis.
Topics: Animals; Carbon Isotopes; Cells, Cultured; Deoxyribonucleosides; Depression, Chemical; DNA; Fluorouracil; Hydroxyurea; In Vitro Techniques; L Cells; Light; Marsupialia; Radiation Effects; Radiobiology; RNA; Thymidine; Tritium; Uridine | 1972 |
Isolation and partial characterization of regulatory mutants of the pyrimidine pathway in Salmonella typhimurium.
Topics: Aspartic Acid; Centrifugation, Density Gradient; Chromosome Mapping; Culture Media; Cytosine Nucleotides; Drug Resistance, Microbial; Feedback; Fluorine; Fluorouracil; Genetics, Microbial; Mutation; Nucleotides; Orotic Acid; Oxidoreductases; Phosphorus; Phosphorus Isotopes; Pyrimidines; Salmonella typhimurium; Transduction, Genetic; Transferases; Uridine | 1972 |
Thiobases in 5-fluorouracil-containing transfer RNA from Escherichia coli.
Topics: Adenosine; Autoradiography; Chromatography, Thin Layer; Cytidine; Escherichia coli; Fluorouracil; Nucleosides; Nucleotides; RNA, Bacterial; RNA, Transfer; Spectrophotometry; Sulfur; Sulfur Isotopes; Tritium; Uridine | 1972 |
[Mechanism of action of ftorafur, a new antineoplastic agent].
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Formates; Hot Temperature; In Vitro Techniques; Leukemia, Experimental; Mice; Neoplasm Transplantation; Orotic Acid; Pentosyltransferases; RNA, Neoplasm; Sarcoma 37; Spectrum Analysis; Uracil; Uridine | 1972 |
Separation of anomeric pyrimidine nucleosides by thin-layer chromatography.
Topics: Chromatography, Thin Layer; Cytidine; Cytosine; Fluorouracil; Methods; Microchemistry; Nucleosides; Pyrimidines; Uridine | 1973 |
Enhancement of radiation effect on transformed fibroblastic cells by a synergistic combination of 5-fluorouracil and polyenes in vitro.
Topics: Amphotericin B; Animals; Carbon Radioisotopes; Cells, Cultured; Drug Synergism; Fibroblasts; Fluorouracil; Polyenes; Radiation Dosage; Radiation Effects; Radiation-Sensitizing Agents; Rats; RNA; Uridine; Vitamin A | 1974 |
The effects of cytostatic drugs on transplanted tumours. An investigation of the correlation between in vivo and in vitro results.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Cricetinae; Cytarabine; Daunorubicin; Fluorouracil; Melanoma; Methotrexate; Mice; Neoplasm Transplantation; Plasmacytoma; Procarbazine; Rats; Thymidine; Tritium; Uridine | 1974 |
Characteristics of an influenza mutant temperature-sensitive for viral RNA synthesis.
Topics: Amino Acids; Animals; Antigens, Viral; Chick Embryo; Culture Techniques; DNA-Directed RNA Polymerases; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Fluorouracil; Hemagglutinins, Viral; Influenza A virus; Mutagens; Mutation; Neuraminidase; Peptide Biosynthesis; RNA, Viral; Temperature; Tritium; Uridine; Viral Proteins; Virus Replication | 1974 |
Semliki forest virus temperature-sensitive mutants: isolation and characterization.
Topics: Animals; Antigens; Centrifugation, Density Gradient; Chick Embryo; Culture Techniques; Fluorescent Antibody Technique; Fluorouracil; Hydroxylamines; Mutagens; Mutation; Nitroso Compounds; RNA, Viral; Semliki forest virus; Temperature; Tritium; Uridine; Viral Proteins | 1969 |
Studies on 5-fluorouracil-containing ribonucleic acid. 3. Greatly reduced level of 5,6-dihydrouridine in fluorouracil-containing transfer ribonucleic acid from Escherichia coli.
Topics: Amino Acids; Colorimetry; Culture Media; Escherichia coli; Fluorouracil; Ligases; Nucleosides; Pyrimidines; RNA, Bacterial; RNA, Transfer; Spectrophotometry; Uridine | 1969 |
Regulation of early RNA synthesis in bacteriophage T4-infected Escherichia coli cells.
Topics: Carbon Isotopes; Coliphages; Escherichia coli; Fluorouracil; Kinetics; Leucine; Mutation; RNA, Messenger; RNA, Viral; Temperature; Thymidine; Tritium; Uridine | 1970 |
Fluorouracil and the isolation of mutants lacking uridine phosphorylase in Escherichia coli: location of the gene.
Topics: Bacteriological Techniques; Chromosome Mapping; Escherichia coli; Fluorouracil; Genes; Genetics, Microbial; Glucosyltransferases; Mutation; Uridine | 1971 |
Comparative effects of 5-fluorouracil on strains of Bacillus megaterium.
Topics: Bacillus megaterium; Bacterial Proteins; Bacteriolysis; DNA, Bacterial; Drug Resistance, Microbial; Fluorouracil; RNA, Bacterial; Thymidine; Uridine | 1964 |
Use of 5-fluorouracil for the isolation of auxotrophic mutants of Bacillus megaterium.
Topics: Amino Acids; Bacillus megaterium; Fluorouracil; Mutation; Ultraviolet Rays; Uridine | 1964 |
Synthesis and biological activity of dinucleoside phosphates containing 5-fluorouracil residues.
Topics: Cell Membrane Permeability; Chemistry, Organic; Chromatography, Paper; Electrophoresis; Enterococcus faecalis; Fluorouracil; Organic Chemistry Phenomena; Spectrophotometry; Thymidine; Uridine | 1966 |
5-mercaptodeoxyuridine--its enzymatic synthesis and mode of action in microbiological systems.
Topics: Biological Assay; Cell-Free System; Chromatography, Ion Exchange; Drug Synergism; Enterococcus faecalis; Fluorouracil; Lactobacillus; Spectrum Analysis; Thymidine; Transferases; Ultraviolet Rays; Uridine | 1969 |
Protein and RNA inhibitors and protozoan habituation.
Topics: Acridines; Benzimidazoles; Chloramphenicol; Ciliophora; Dactinomycin; Depression, Chemical; Fluorouracil; Habituation, Psychophysiologic; Learning; Leucine; Memory; Protein Biosynthesis; Puromycin; RNA; Uridine | 1970 |
Requirement of cellular synthesis for Kilham rat virus replication.
Topics: Animals; Autoradiography; Culture Techniques; DNA; Fluorescent Antibody Technique; Fluorouracil; Herpesviridae; Leucine; Radiation Effects; Rats; Species Specificity; Thymidine; Tritium; Ultraviolet Rays; Uridine; Virus Cultivation; Virus Replication; Viruses, Unclassified | 1970 |
[Experimental findings in animals concerning radiation sensitization in partial and whole body irradiation].
Topics: Acetates; Animals; Antibiotics, Antineoplastic; Dogs; Fluorouracil; Glyoxylates; Hydrazines; Hydroquinones; Hydroxymercuribenzoates; Iron; Maleimides; Mice; Oxygen; Procarbazine; Radiation Effects; Radiation-Sensitizing Agents; Rats; Uridine; Vitamin K | 1972 |
[Use of radiation sensitizing agents in radiotherapy].
Topics: Acetates; Anti-Bacterial Agents; Antimetabolites; Antineoplastic Agents; Choline; Cysteine; Fluorouracil; Hematoporphyrins; Humans; Hydrogen Peroxide; Mitosis; Nitrogen Oxides; Oxygen; Periodicity; Quinones; Radiation-Sensitizing Agents; Radiotherapy; Steroids; Thyroid Hormones; Trypan Blue; Urethane; Uridine; Vitamins | 1972 |
Arginine requirement for late mRNA transcription of vaccinia virus in KB cells.
Topics: Arginine; Carbon Isotopes; Carcinoma; Cell Line; Centrifugation, Density Gradient; DNA Replication; DNA, Viral; Fluorouracil; Humans; Mouth Neoplasms; Nucleic Acid Hybridization; RNA, Messenger; Uridine; Vaccinia virus | 1971 |
Cytostatic and immunologic activity of 5-mercaptouracil desoxyriboside in the management of multiple superficial basal cell epitheliomas.
Topics: Antimetabolites; Carcinoma, Basal Cell; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Humans; Hypersensitivity, Delayed; Skin Neoplasms; Sulfhydryl Compounds; Uridine | 1970 |
Regulation of nucleoside triphosphate pools in Escherichia coli.
Topics: Adenine; Carbon Isotopes; Cytosine Nucleotides; Escherichia coli; Fluorouracil; Nucleotides; RNA, Bacterial; Uracil; Uridine | 1967 |
Metabolism of uracil and 5-fluorouracil in P388 murine leukemia cells.
Topics: Animals; Carbon Isotopes; Cell Line; Cell-Free System; Culture Techniques; Fluorouracil; Leukemia, Experimental; Nucleosides; Nucleotides; Phosphotransferases; Pyrimidines; RNA; Thymidine; Transferases; Uracil; Uridine | 1969 |
Genetic and physiological aspects of resistance to 5-fluoropyrimidines in Saccharomyces cerevisiae.
Topics: Aminohydrolases; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Chromatography, Thin Layer; Chromosome Mapping; Cytosine; Drug Resistance, Microbial; Fluorine; Fluorouracil; Genetics, Microbial; Membrane Transport Proteins; Mutation; Phosphorus Isotopes; Phosphotransferases; Saccharomyces; Spectrophotometry; Transferases; Uracil; Uridine | 1970 |
Loss of labelled DNA from rat brain following injections of precursors with high specific radioactivity. II. DNA labelled with 5-[131I]iodo-2'-deoxyuridine and 5-[82Br]bromo-2'-deoxyuridine.
Topics: Brain; Bromine; Bromodeoxyuridine; Centrifugation, Density Gradient; Chromatography, Ion Exchange; DNA; Fluorouracil; Hot Temperature; Iodine; Iodine Isotopes; Nucleic Acid Denaturation; Radioisotopes; Tritium; Uridine | 1970 |
The effect of 5-fluorouracil on cells and regenerating protoplsts of Saccharoyces cerevisiae.
Topics: Agar; Cell Wall; Culture Media; Cytosine Nucleotides; DNA; Fluorouracil; Methods; Microbial Sensitivity Tests; Microscopy, Electron; Protein Biosynthesis; Proteins; Protoplasts; RNA; Saccharomyces; Time Factors; Uracil; Uridine | 1970 |
Studies on the mechanism of action of progesterone in regulation of the synthesis of specific protein.
Topics: Amino Acids; Animals; Chickens; Colchicine; Culture Techniques; Cycloheximide; Dactinomycin; Diethylstilbestrol; Estrogens; Female; Fluorouracil; Hydroxyurea; Mitosis; Muramidase; Ovalbumin; Oviducts; Progesterone; Protein Biosynthesis; RNA; RNA Nucleotidyltransferases; Thymidine; Tritium; Uridine | 1968 |
On the mechanism of the lethal action of 5-fluorouracil on mouse L cells.
Topics: Dialysis; Fibroblasts; Fluorouracil; In Vitro Techniques; L Cells; Thymidine; Time Factors; Uridine | 1968 |
Transplacental passage of nucleotides, nucleosides, and bases.
Topics: Alkalies; Animals; Carbon Isotopes; Colchicine; Female; Fetus; Fluorouracil; Injections, Intraperitoneal; Injections, Intravenous; Liver; Maternal-Fetal Exchange; Nucleosides; Nucleotides; Orotic Acid; Placenta; Pregnancy; Purines; Pyrimidines; Radiometry; Rats; RNA; Solubility; Thymidine; Time Factors; Uracil Nucleotides; Uridine | 1968 |
Biochemistry of germination in Peronospora tabacina (Adam) conidia: evidence for the existence of stable messenger RNA.
Topics: Carbon Isotopes; Cycloheximide; Fluorouracil; Fungi; Nucleosides; Protein Biosynthesis; RNA; RNA, Messenger; Spores; Tritium; Uridine | 1969 |
[A study of the incorporation of 5-fluorouracil into transfer and ribosomal ribonucleic acids of yeast].
Topics: Carbon Isotopes; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Chromatography; Depression, Chemical; Fluorouracil; Polynucleotides; Pyrimidines; Ribosomes; RNA; RNA, Transfer; Saccharomyces; Spectrophotometry; Tritium; Uracil; Uridine | 1969 |
Relationship between deoxyribonucleic acid-like ribonucleic acid synthesis and inhibition of host protein synthesis in type 5 adenovirus-infected KB cells.
Topics: Adenoviridae; Carbon Isotopes; Culture Techniques; DNA; Fluorouracil; Hybridization, Genetic; Immunochemistry; Nucleic Acid Denaturation; Protein Biosynthesis; RNA; RNA, Viral; Tritium; Uridine; Valine; Viral Proteins | 1969 |
Antiglycolytic activities of 5-fluorouracil and related pyrimidines in mouse ascites carcinoma cells with special reference to inorganic phosphate and glucose.
Topics: Adenine; Animals; Arsenic; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Deoxyuridine; Fluorouracil; Fructose; Glucose; Glutamine; Glycolysis; In Vitro Techniques; Manometry; Mice; Nucleosides; Phenols; Phosphates; Pyrimidines; Pyruvates; Respiration; Succinates; Uracil; Uridine | 1969 |
Influence of antiblastic agents applied either in vivo or in vitro on human lymphocyte transformation in cell culture.
Topics: Antineoplastic Agents; Autoradiography; Colchicine; Culture Techniques; Cyclophosphamide; Daunorubicin; Fluorouracil; Humans; Hydrazines; Lectins; Lymphocyte Activation; Lymphocytes; Mechlorethamine; Prednisolone; Radiation Effects; Thymidine; Tritium; Uridine; Vinblastine | 1969 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergism; Embryo, Mammalian; Female; Fluorouracil; Injections, Intraperitoneal; Kidney; Liver; Male; Maternal-Fetal Exchange; Pregnancy; Pyrimidines; Rats; Thymidine; Thymine; Uracil; Uridine | 1969 |
Mechanism of growth inhibition by 5-fluorouracil. Reversal studies with pyrimidine metabolites in vitro.
Topics: Animals; Carcinoma, Ehrlich Tumor; Culture Techniques; Depression, Chemical; DNA, Neoplasm; Fluorouracil; Mice; Nucleotides; Orotic Acid; RNA, Neoplasm; Thymidine; Uridine | 1969 |
Viruses grown in the presence of base analogs: specific alteration of susceptibility to inactivation by radiations, mutagens, and protodyes.
Topics: Arboviruses; Coloring Agents; Fluorouracil; Guanine; Hydroxylamines; In Vitro Techniques; Light; Methylene Blue; Newcastle disease virus; Nitrites; Nucleic Acids; Nucleosides; Photosensitivity Disorders; Purines; Sulfates; Thiouracil; Ultraviolet Rays; Uracil; Uridine; Virus Cultivation; Xanthine Oxidase | 1966 |
Effects of ultraviolet radiation on RNA C-C glycosyls and other derivatives of uracil.
Topics: Chemical Phenomena; Chemistry, Physical; Fluorouracil; Nucleosides; Radiation Effects; RNA, Transfer; Spectrophotometry; Thymidine; Thymine; Ultraviolet Rays; Uracil; Uridine | 1966 |
Continued studies of combined chemotherapy and irradiation in inoperable bronchogenic carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Bronchogenic; Cyclophosphamide; Female; Fluorouracil; Humans; Male; Middle Aged; Uridine | 1967 |
Cellular mutations and drug resistance probed by herpes simplex virus.
Topics: Animals; Bleomycin; Carcinoma, Squamous Cell; Chlorocebus aethiops; Drug Resistance; Fibroblasts; Fluorescent Antibody Technique; Fluorouracil; Humans; Methotrexate; Mice; Mutation; Simplexvirus; Thioguanine; Uridine | 1981 |
Adjuvant and palliative treatment of colorectal cancer with fluorinated pyrimidines. A pharmacological and clinical review.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Prognosis; Pyrimidines; Rectal Neoplasms; Uridine | 1981 |
Uridine rescue from the lethal toxicity of 5-fluorouracil in mice.
Topics: Animals; Deoxyuridine; Fluorouracil; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; RNA; Thymidine; Uridine | 1982 |
Biochemical basis for the differential sensitivity of human T- and B-lymphocyte lines to 5-fluorouracil.
Topics: B-Lymphocytes; Biotransformation; Cell Line; Fluorodeoxyuridylate; Fluorouracil; Humans; Orotate Phosphoribosyltransferase; Orotic Acid; RNA; T-Lymphocytes; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase; Uridine Triphosphate | 1982 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.
Topics: Breast Neoplasms; Cell-Free System; Cytosol; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Phosphorylation; Uridine | 1981 |
Nitrogen metabolite repression of fluoropyrimidine resistance and pyrimidine uptake in Neurospora crassa.
Topics: Ammonia; Biological Transport; Drug Resistance, Microbial; Fluorouracil; Mutation; Neurospora; Neurospora crassa; Nitrogen; Pyrimidines; Temperature; Uracil; Uridine | 1982 |
Mode of action of 5-fluorocytosine and 5-fluorouracil in dematiaceous fungi.
Topics: Cytosine; Drug Resistance, Microbial; Floxuridine; Flucytosine; Fluorouracil; Mitosporic Fungi; RNA, Fungal; RNA, Ribosomal; Species Specificity; Uridine | 1983 |
Decreased immunosuppression associated with antitumor activity of 5-deoxy-5-fluorouridine compared to 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Survival; Female; Floxuridine; Fluorouracil; Immunosuppression Therapy; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrans; Thioglycolates; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.
Topics: Animals; Bile; Floxuridine; Fluorine; Fluorouracil; Radioisotopes; Rats; Rats, Inbred Strains; Uridine | 1984 |
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Floxuridine; Fluorouracil; Guanosine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleosides; Uridine | 1984 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Rats; Uridine | 1984 |
[Approaches to a selective chemotherapy of hepatocellular carcinoma (author's transl)].
Topics: Antineoplastic Agents; Asialoglycoproteins; Azo Compounds; Carcinoma, Hepatocellular; Cell Membrane Permeability; Doxorubicin; Drug Therapy, Combination; Enzyme Activation; Fluorouracil; Glycoproteins; Humans; Injections, Intra-Arterial; Liver Neoplasms; NADH, NADPH Oxidoreductases; Nitroreductases; Pyrimidine Nucleotides; Uridine | 1981 |
[Experiences with Volm's short-term tumor test in the primary treatment of ovarian carcinoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cell Division; Cells, Cultured; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Resistance; Female; Fluorouracil; Humans; Ovarian Neoplasms; Prognosis; Thymidine; Uridine | 1984 |
[Regulation of enzyme activities involved in pyrimidine synthesis and its application to cancer chemotherapy].
Topics: Administration, Oral; Animals; Deoxyuridine; Dihydrouracil Dehydrogenase (NAD+); DNA, Neoplasm; Drug Synergism; Fluorouracil; Neoplasms, Experimental; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pentosyltransferases; Phosphorylation; Pyrimidines; Sarcoma, Yoshida; Tegafur; Thymidine; Thymine; Uracil; Uridine | 1984 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine | 1980 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransferases; Sarcoma 180; Tegafur; Thymidine; Uridine; Uridine Phosphorylase | 1980 |
Mechanism of cytotoxicity of 5-fluorouracil: distinction between the irreversible cytotoxic effect of 5-fluorouridine and the reversible cytotoxic effect of 5-fluoro-2'-deoxyuridine on murine lymphoma L5178Y cells in culture.
Topics: Animals; Cell Division; Cell Line; Floxuridine; Fluorouracil; Leukemia, Experimental; Mice; Uridine | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidylate Synthase; Uridine | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Uridine | 1980 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Mutation; Phenotype; Selection, Genetic; Uridine | 1982 |
Phase I and pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity.
Topics: Adult; Aged; Drug Evaluation; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Uracil; Uridine | 1984 |
Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars.
Topics: Animals; Aspartic Acid; Cell Line; Cells, Cultured; Chromatography; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Humans; Melanoma; Mice; Phosphonoacetic Acid; RNA, Neoplasm; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1984 |
Improved therapeutic index with sequential N-phosphonacetyl-L-aspartate plus high-dose methotrexate plus high-dose 5-fluorouracil and appropriate rescue.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Drug Therapy, Combination; Female; Fluorouracil; Leucovorin; Male; Methotrexate; Mice; Neoplasms; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1983 |
[Induction of resistance of yeast-like fungi to synthetic antifungal agents].
Topics: Antifungal Agents; Candida; Clotrimazole; Culture Techniques; Drug Resistance, Microbial; Flucytosine; Fluorouracil; Miconazole; Uridine | 1983 |
Relationship between antitumor effect and metabolites of 5-fluorouracil in combination treatment with 5-fluorouracil and guanosine in ascites sarcoma 180 tumor system.
Topics: Adenosine; Animals; Carbon Radioisotopes; Cytidine; Dose-Response Relationship, Drug; Female; Fluorouracil; Guanosine; Mice; Mice, Inbred Strains; Sarcoma 180; Structure-Activity Relationship; Uridine | 1983 |
Human tissues degrade uridine much less than thymidine. Possible consequence for 5-fluorouracil therapy.
Topics: Animals; Deoxyuridine; Fluorouracil; Humans; In Vitro Techniques; Liver; Mice; Models, Biological; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Spleen; Thymidine; Tissue Distribution; Uridine | 1984 |
Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Uracil; Uric Acid; Uridine | 1984 |
Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized.
Topics: Animals; Cell Compartmentation; Cell Nucleus; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytosol; Fluorouracil; Leukemia L1210; Mice; RNA, Neoplasm; Sepharose; Uracil Nucleotides; Uridine | 1984 |
Effect of coadministration of thymine or thymidine on the antitumor activity of 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biodegradation, Environmental; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Liver; Male; Mice; Phosphorylation; Rats; Sarcoma 180; Sarcoma, Yoshida; Tegafur; Thymidine; Thymidine Phosphorylase; Thymine; Uracil; Uridine; Uridine Phosphorylase | 1980 |
Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.
Topics: Animals; Cell Division; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mitosis; Neoplasm Transplantation; Tegafur; Thymidine; Transplantation, Homologous; Uridine | 1981 |
Increased uptake of 5-fluorouracil by Ehrlich ascites tumor cells with some additives and metabolite analysis.
Topics: Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane Permeability; Deoxyuridine; Detergents; Edetic Acid; Fluorouracil; Male; Mice; Mice, Inbred Strains; Polyamines; Ribosemonophosphates; RNA, Neoplasm; Uridine | 1982 |
In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine.
Topics: Cell Line; Centrifugation, Density Gradient; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Humans; Protein Biosynthesis; RNA, Messenger; Uridine | 1983 |
Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil.
Topics: Animals; Bone Marrow; Deoxyuridine; Drug Therapy, Combination; Fluorouracil; Infusions, Parenteral; Injections, Intraperitoneal; Leukemia L1210; Male; Melanoma; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Uridine | 1983 |
Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture.
Topics: Cell Nucleus; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Neoplasms, Experimental; RNA, Neoplasm; Uridine | 1982 |
High-dose 5-fluorouracil with delayed uridine "rescue" in mice.
Topics: Animals; Colonic Neoplasms; Fluorouracil; Kinetics; Leukopenia; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Uridine | 1982 |
Additive formation of antineoplastic 5-fluorouracil nucleosides from 5-fluorouracil by Ehrlich ascites tumor extracts in the presence of ribose 1-phosphate/uridine or deoxyribose 1-phosphate/deoxyuridine.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Deoxyuridine; Fluorouracil; In Vitro Techniques; Liver; Male; Mice; Ribosemonophosphates; Uridine | 1982 |
Influence of pH and serum on the effectivity of antineoplastic agents in vitro.
Topics: Antineoplastic Agents; Cells, Cultured; Culture Media; Fluorouracil; Humans; Hydrogen-Ion Concentration; Mesothelioma; Thymidine; Uridine; Vinblastine | 1981 |
Influence of pyrazofurin on the toxicity and antitumor activity of fluorinated pyrimidines in vivo.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Drug Interactions; Drug Therapy, Combination; Female; Fluorouracil; Hematopoietic Stem Cells; Male; Mice; Neoplasms, Experimental; Pyrazoles; Ribonucleosides; Ribose; Uridine | 1980 |
Dynamic histology of a rat hepatoma and the response to 5-fluorouracil.
Topics: Animals; DNA, Neoplasm; Female; Fluorouracil; Kinetics; Liver Neoplasms, Experimental; Mitotic Index; Rats; Rats, Inbred ACI; Thymidine; Uridine | 1980 |
[Experimental study of the combined effect of 5-fluorouracil and cyclophosphane on growth of Zajdela hepatoma and nucleic acid metabolism].
Topics: Animals; Cyclophosphamide; DNA, Neoplasm; Drug Therapy, Combination; Fluorouracil; Liver Neoplasms, Experimental; Male; Neoplasm Transplantation; Rats; RNA, Neoplasm; Thymidine; Uridine | 1980 |
Simultaneous liquid chromatography of 5-fluorouracil, uridine, hypoxanthine, xanthine, uric acid, allopurinol, and oxipurinol in plasma.
Topics: Allopurinol; Blood Platelets; Chromatography, High Pressure Liquid; Erythrocytes; Fluorouracil; Humans; Hypoxanthines; Oxypurinol; Purinones; Pyrimidines; Uric Acid; Uridine; Xanthines | 1980 |
Evaluation of plasma 5-fluorouracil nucleoside levels in patients with metastatic breast cancer: relationships with toxicities.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Uridine | 1995 |
Incorporation of 5-fluorouracil into RNA by Mycobacterium avium complex strain LM1.
Topics: Biotransformation; Cytidine; Drug Resistance, Microbial; Fluorouracil; Mycobacterium avium Complex; RNA, Bacterial; Uracil; Uridine | 1993 |
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; KB Cells; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1995 |
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
Topics: Biotransformation; Cell Division; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Fluorouracil; Humans; Interleukin-1; Prodrugs; Receptors, Interleukin-1; Recombinant Proteins; RNA, Neoplasm; Thymidine; Thymine Nucleotides; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine; Uridine Triphosphate | 1994 |
Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells.
Topics: Cell Cycle; Cell Survival; Colorectal Neoplasms; DNA, Neoplasm; DNA, Ribosomal; Dose-Response Relationship, Drug; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1994 |
Therapeutic effect of reticuloendothelial system (RES)-avoiding liposomes containing a phospholipid analogue of 5-fluorouracil, dipalmitoylphosphatidylfluorouridine, in Meth A sarcoma-bearing mice.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Antineoplastic Agents; Cell Division; Drug Carriers; Drug Delivery Systems; Fluorouracil; Glucuronates; Glycerophospholipids; Injections, Intravenous; Lipid Bilayers; Liposomes; Methylcholanthrene; Mice; Mice, Inbred BALB C; Mononuclear Phagocyte System; Phosphatidic Acids; Phosphatidylglycerols; Phospholipids; Sarcoma, Experimental; Uridine | 1994 |
Somatostatin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids.
Topics: Adenocarcinoma; Amino Acid Sequence; Cell Cycle; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorine; Fluorouracil; G1 Phase; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Octreotide; Receptors, Somatostatin; Resting Phase, Cell Cycle; RNA, Ribosomal; S Phase; Tumor Cells, Cultured; Uridine | 1994 |
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation.
Topics: Adenocarcinoma; Cell Division; Chalcone; Chalcones; Colonic Neoplasms; Flavonoids; Fluorouracil; Humans; Phenols; Polymers; Polyphenols; Tumor Cells, Cultured; Uridine | 1994 |
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Liver; Mice; Placenta; Species Specificity; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 1993 |
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Incidence; Injections; Rabbits; Retinal Detachment; Retinal Diseases; RNA, Ribosomal; Uridine; Vitreous Body | 1993 |
Uridine allows dose escalation of 5-fluorouracil when given with N-phosphonacetyl-L-aspartate, methotrexate, and leucovorin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Diarrhea; Drug Synergism; Female; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Mouth Mucosa; Neoplasms; Phosphonoacetic Acid; Stomatitis; Uridine | 1993 |
Novel low immunosuppressive derivatives of the antitumor drug fluoropyrimidine, UK-21 and UK-25: effect on delayed type hypersensitivity and tumor immunity.
Topics: Animals; Antineoplastic Agents; Erythrocytes; Female; Fluorouracil; Glycine; Hypersensitivity, Delayed; Immunity; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Sheep; Spleen; Uridine | 1993 |
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Interferon-gamma; Interleukin-1; Mice; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uridine; Uridine Phosphorylase | 1993 |
Biochemical consequences of 5-fluorouracil gastrointestinal toxicity in rats; effect of high-dose uridine.
Topics: Animals; Dose-Response Relationship, Drug; Fluorouracil; Gastrointestinal Diseases; Intestinal Mucosa; Male; Rats; Rats, Wistar; Uridine | 1993 |
Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine.
Topics: Administration, Oral; Adult; Aged; Drug Therapy, Combination; Female; Fluorouracil; Humans; Leukopenia; Male; Middle Aged; Neoplasms; Thrombocytopenia; Uridine | 1993 |
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation.
Topics: Animals; Apoptosis; Colon; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Gene Expression Regulation; Histocytochemistry; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred Strains; Quinazolines; RNA; Thiophenes; Thymidine; Thymidylate Synthase; Tumor Suppressor Protein p53; Uridine | 1997 |
Irreversible cytotoxic effect of a novel lowly immunosuppressive antitumor fluorouridine derivative, UK-21.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; Flow Cytometry; Floxuridine; Fluorouracil; Glycine; Humans; Immunosuppressive Agents; KB Cells; Neoplastic Stem Cells; Thymidine; Uridine | 1997 |
Synthesis of novel dioxane nucleosides having two bases, physico-chemical properties, and their biological activities.
Topics: Antimetabolites, Antineoplastic; Dioxanes; Fluorouracil; Humans; Indicators and Reagents; Molecular Structure; Stomach Neoplasms; Tumor Cells, Cultured; Uridine | 1997 |
Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells.
Topics: Antimetabolites, Antineoplastic; Cell Count; Colorectal Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Intracellular Fluid; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1998 |
Effect of coadministered uridine on intestinal first-pass metabolism of 5'-deoxy-5-fluorouridine in conscious rats--an evaluation by method of portal-systemic concentration difference.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arteries; Drug Interactions; Floxuridine; Fluorouracil; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Portal System; Portal Vein; Rats; Rats, Wistar; Uridine | 1998 |
Bladder tissue pharmacokinetics and antitumor effect of intravesical 5-fluorouridine.
Topics: Administration, Intravesical; Animals; Antibiotics, Antineoplastic; Biological Availability; Dogs; Female; Fluorouracil; Humans; Male; Metabolic Clearance Rate; Uridine; Urinary Bladder; Urinary Bladder Neoplasms | 1997 |
Differences in metabolism of 5-fluorouracil and 5-fluorouridine and regulation by glucosamine in human colon cancer multicell tumor spheroids.
Topics: Body Fluid Compartments; Colonic Neoplasms; Fluorouracil; Glucosamine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Biological; Nonlinear Dynamics; Phosphates; Spheroids, Cellular; Uridine | 1999 |
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Colonic Neoplasms; Deoxyuridine; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Treatment Outcome; Uracil; Uridine | 1999 |
Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2',3',5'-tri-O-acetyluridine, a prodrug of uridine.
Topics: Acetates; Animals; Antimetabolites, Antineoplastic; Barbiturates; Drug Interactions; Enzyme Inhibitors; Female; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Prodrugs; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 2000 |
Kinetic model for 5-fluorouridine degradation. Catalytic effect of 5-fluorouracil.
Topics: Algorithms; Catalysis; Fluorouracil; Hydrolysis; Kinetics; Models, Chemical; Uridine | 2000 |
Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cells, Cultured; Embryo, Mammalian; Fluorouracil; Mice; Mice, Knockout; Proteins; Pyrimidines; Stem Cells; Uridine; Uridine Phosphorylase | 2002 |
RP-LC determination of 5-fluorouridine in nanoparticulate formulations.
Topics: Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Fluorouracil; Reproducibility of Results; Solutions; Uridine | 2002 |
In-vitro release of fluoropyrimidines from PLGA film implants.
Topics: Absorbable Implants; Analysis of Variance; Chromatography, High Pressure Liquid; Drug Carriers; Drug Implants; Fluorouracil; Humans; Polyglactin 910; Uridine | 2002 |
Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uridine | 1958 |
EFFECTS OF 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) AND 5-FLUOROURACIL (NSC-19893) ON CHILDHOOD LEUKEMIA.
Topics: Bone Marrow Examination; Child; Floxuridine; Fluorouracil; Leukemia; Leukopenia; Melena; Nausea; Toxicology; Uridine; Vomiting | 1964 |
UPTAKE AND INCORPORATION OF THYMINE, THYMIDINE, URACIL, URIDINE, AND 5-FLUOROURACIL INTO THE NUCLEIC ACIDS OF BACILLUS SUBTILIS.
Topics: Bacillus subtilis; Carbon Isotopes; DNA; DNA, Bacterial; Fluorouracil; Metabolism; Nucleosides; Research; RNA; RNA, Bacterial; Thymidine; Thymine; Tritium; Uracil; Uridine | 1965 |
COMPARISON OF 5-FLUOROURACIL (NSC-19893) AND 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) IN TREATMENT OF PATIENTS WITH ADVANCED ADENOCARCINOMA OF COLON OR RECTUM.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Deoxyuridine; Drug Therapy; Fluorouracil; Humans; Nucleosides; Palliative Care; Rectal Neoplasms; Rectum; Toxicology; Uridine | 1965 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Irinotecan; Nucleic Acids; Organoplatinum Compounds; Oxaliplatin; Uridine | 2004 |
5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Body Weight; Female; Fluorouracil; Mice; Mice, Inbred Strains; Thiouracil; Uracil; Uridine; Uridine Phosphorylase | 2005 |
Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene.
Topics: Adenosine; Animals; Antimetabolites, Antineoplastic; Blotting, Southern; Cytidine; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Fluorouracil; Gene Deletion; Guanosine; Intestinal Mucosa; Kidney; Kinetics; Liver; Lung; Mice; Mice, Transgenic; Nucleotides; Pentobarbital; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA, Messenger; Thymine Nucleotides; Time Factors; Tissue Distribution; Uridine; Uridine Phosphorylase | 2005 |
5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice.
Topics: Acetates; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Survival Rate; Tumor Burden; Uridine; Xenograft Model Antitumor Assays | 2006 |
Continued survival of more than ten years, without resection of metastatic disease, in patients with metastatic colorectal cancer treated with biomodulated fluorouracil: report of two cases.
Topics: Acetates; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Immunologic Factors; Leucovorin; Liver Neoplasms; Male; Methotrexate; Middle Aged; Phosphonoacetic Acid; Remission Induction; Uridine; Vitamin B Complex | 2006 |
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorouracil; Humans; Male; Mice; Mice, SCID; Survival Analysis; Thiouracil; Uridine; Uridine Phosphorylase; Xenograft Model Antitumor Assays | 2006 |
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
Topics: Acridine Orange; Adenosine; Animals; Antibiotics, Antineoplastic; beta-Galactosidase; Cell Line; Cytidine; Drug Evaluation, Preclinical; Enzyme Inhibitors; Ethidium; Fluorouracil; Gene Expression Regulation, Enzymologic; Guanine; Humans; Mice; Mice, Nude; Molecular Structure; RNA, Catalytic; Toyocamycin; Tubercidin; Uridine | 2006 |
Trypanosoma brucei: a survey of pyrimidine transport activities.
Topics: Animals; Antimetabolites; Biological Transport; Cytidine; Cytosine; Female; Fluorouracil; Parasitic Sensitivity Tests; Pyrimidines; Rats; Rats, Wistar; Thymidine; Thymine; Trypanocidal Agents; Trypanosoma brucei brucei; Uridine | 2006 |
Anticancer nucleobase analogues 6-mercaptopurine and 6-thioguanine are novel substrates for equilibrative nucleoside transporter 2.
Topics: Animals; Antimetabolites, Antineoplastic; Binding, Competitive; Cell Membrane Permeability; Chlorocebus aethiops; COS Cells; Equilibrative-Nucleoside Transporter 2; Fluorouracil; Guanine; Hypoxanthine; Kinetics; Mercaptopurine; Mice; Thioguanine; Transfection; Uracil; Uridine | 2007 |
The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.
Topics: Azacitidine; Bromodeoxyuridine; Decitabine; Deoxyuridine; DNA Damage; Escherichia coli; Escherichia coli Proteins; Fluorouracil; Models, Biological; Molecular Structure; Mutation; N-Glycosyl Hydrolases; Nucleotidases; Orotic Acid; Substrate Specificity; Thymidine Monophosphate; Uridine | 2007 |
Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Cell Line; Cystic Fibrosis; Dihydropteroate Synthase; Fluorouracil; Folic Acid Antagonists; Humans; Lung; Phenotype; Staphylococcus aureus; Thymidine; Trimethoprim, Sulfamethoxazole Drug Combination; Uridine | 2008 |
Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Mice; RNA; RNA Interference; Sensitivity and Specificity; Thymidylate Synthase; Uridine | 2008 |
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.
Topics: Adult Stem Cells; Animals; Antigens, Differentiation; Bone Marrow; Bromouracil; Fluorouracil; Green Fluorescent Proteins; Hematopoietic Stem Cells; Homeostasis; Mice; Mice, Transgenic; Uridine | 2008 |
Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.
Topics: Alleles; Antimetabolites, Antineoplastic; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; Fluorouracil; Genes, p53; HCT116 Cells; Humans; Molecular Sequence Data; Mutation; RNA, Messenger; RNA, Neoplasm; Thymidine; Thymidylate Synthase; Uridine; Yeasts | 2009 |
Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Epigenomics; Fluorouracil; Gene Expression Regulation, Neoplastic; Gene Order; Humans; Mice; Mice, Nude; Molecular Sequence Data; Nucleoside-Phosphate Kinase; Promoter Regions, Genetic; RNA Stability; Uridine; Xenograft Model Antitumor Assays | 2009 |
Active site conformational dynamics in human uridine phosphorylase 1.
Topics: Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Dimerization; Fluorouracil; Humans; Molecular Conformation; Protein Binding; Protein Conformation; Substrate Specificity; Uridine; Uridine Phosphorylase | 2010 |
Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
Topics: Animals; Apoptosis; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluorouracil; Humans; Mice; Pyrophosphatases; RNA, Small Interfering; Uridine; Xenograft Model Antitumor Assays | 2011 |
N⁴-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine-new drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate).
Topics: Alendronate; Animals; Antimetabolites, Antineoplastic; Arabinofuranosyluracil; Bone and Bones; Bone Density Conservation Agents; Cell Line, Tumor; Cytidine; Diphosphonates; Drug Screening Assays, Antitumor; Durapatite; Fluorouracil; Humans; Macrophages; Mice; Pamidronate; Uridine; Zidovudine | 2011 |
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Topics: Animals; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Floxuridine; Fluorouracil; Gene Knockdown Techniques; Humans; Mice; MutS Homolog 2 Protein; RNA; Thymidine; Thymine DNA Glycosylase; Uracil-DNA Glycosidase; Uridine | 2011 |
Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biomass; Cellulose; Fluorouracil; Isoenzymes; Light; Lignin; Mutagenesis, Insertional; Orotic Acid; Pentosyltransferases; Phenotype; Plant Leaves; Plants, Genetically Modified; Plastids; Recombinant Fusion Proteins; Seeds; Starch; Uracil; Uridine; Uridine Kinase | 2011 |
Use of uridine triacetate for the management of fluorouracil overdose.
Topics: Antiemetics; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Overdose; Fluorouracil; Home Infusion Therapy; Humans; Leucovorin; Male; Medication Errors; Middle Aged; Ondansetron; Organoplatinum Compounds; Uridine | 2011 |
Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Female; Fluorouracil; Humans; Mice; Mice, SCID; Thiouracil; Uridine; Xenograft Model Antitumor Assays | 2012 |
Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.
Topics: Biological Transport; Fluorouracil; Genome-Wide Association Study; Glycosylation; Nucleoside Transport Proteins; Pyrimidines; Trypanosoma brucei brucei; Uracil; Uridine | 2013 |
Low-temperature NMR studies on the geometry of base pairs involving 5-substituted uracil derivatives.
Topics: Adenosine; Base Pairing; Bromouracil; Cold Temperature; Fluorouracil; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Thymidine; Uracil; Uridine | 2013 |
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Topics: Administration, Oral; Algorithms; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Floxuridine; Fluorouracil; Indicators and Reagents; Mass Spectrometry; Tandem Mass Spectrometry; Uridine | 2013 |
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.
Topics: Amides; Animals; Biological Transport; Cell Line; Deoxyuridine; Fluorouracil; Gene Knockout Techniques; Mice; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Transfection; Trypanocidal Agents; Trypanosoma brucei brucei; Uracil; Uridine; Uridine Monophosphate; Virulence | 2013 |
Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole.
Topics: Antifungal Agents; Azoles; Biological Transport; Candida; Crosses, Genetic; Drug Antagonism; Drug Resistance, Fungal; Flucytosine; Fluorouracil; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Microbial Sensitivity Tests; Nucleobase Transport Proteins; Nucleotide Transport Proteins; Sterol 14-Demethylase; Uracil; Uridine | 2014 |
Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis.
Topics: Animals; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Female; Fluorouracil; Humans; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Mucositis; Peroxidase; Pyridones; Rats, Wistar; Uridine; Uridine Phosphorylase | 2014 |
FDA approves therapy to treat overdose of fluorouracil, capecitabine.
Topics: Acetates; Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Chemistry, Pharmaceutical; Drug Approval; Drug Overdose; Fluorouracil; Humans; United States; United States Food and Drug Administration; Uridine | 2016 |
Effect of Metabolic Inhibitors on the Hepatic Disposition of 5-Fluorouracil after Application to the Rat Liver Surface.
Topics: Animals; Antimetabolites, Antineoplastic; Fluorouracil; Liver; Male; Pyridines; Rats, Wistar; Uridine | 2016 |
Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency.
Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Male; Pancreatic Neoplasms; Severity of Illness Index; Time Factors; Uridine | 2016 |
In brief: uridine triacetate (Vistogard) for fluorouracil overdose.
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Drug Overdose; Fluorouracil; Humans; Treatment Outcome; Uridine | 2016 |
Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity.
Topics: Acetates; Antimetabolites, Antineoplastic; Capecitabine; Drug Overdose; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Uridine | 2017 |
An antidote to fluorouracil and capecitabine toxicity.
Topics: Acetates; Antidotes; Antineoplastic Agents; Capecitabine; Drug Costs; Drug Overdose; Fluorouracil; Humans; Treatment Outcome; Uridine | 2016 |
Early-Onset 5-Fluorouracil Toxicity in a Patient Negative for Dihydropyrimidine Dehydrogenase Mutations: The Clinical Course of Reversal with Uridine Triacetate.
Topics: Acetates; Aged; Antidotes; Antimetabolites, Antineoplastic; Anus Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fatigue; Fluorouracil; Follow-Up Studies; Humans; Male; Mucositis; Mutation; Neutrophils; Time Factors; Uridine | 2016 |
The successful treatment of 5-fluorouracil (5-FU) overdose in a patient with malignancy and HIV/AIDS with uridine triacetate.
Topics: Acetates; Antimetabolites, Antineoplastic; Anus Neoplasms; Depression; Drug Overdose; Emergency Medicine; Fluorouracil; HIV Infections; Humans; Male; Middle Aged; Toxoplasmosis, Cerebral; Treatment Outcome; Uridine | 2017 |
Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency.
Topics: Acetates; Animals; Antidotes; Antimetabolites, Antineoplastic; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dose-Response Relationship, Drug; Drug Overdose; Female; Fluorouracil; Mice; Survival Analysis; Uridine | 2018 |
[5-FU: At last!]
Topics: Acetates; Antidotes; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Fluorouracil; Humans; Neoplasms; Practice Guidelines as Topic; Pyrimidines; Uracil; Uridine | 2019 |
BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; DNA Damage; Drug Resistance, Neoplasm; Fluorouracil; Mammals; Mice; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Protein Binding; Protein Domains; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53; Uridine | 2019 |
FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA.
Topics: Cell Survival; Deoxyribonucleases; Fluorouracil; HEK293 Cells; High-Throughput Nucleotide Sequencing; Humans; RNA; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; tRNA Methyltransferases; Uridine; Yeasts | 2019 |
Determination of 5-fluorocytosine, 5-fluorouracil, and 5-fluorouridine in hospital wastewater by liquid chromatography-mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Flucytosine; Fluorouracil; Hospitals; Molecular Structure; Solid Phase Extraction; Tandem Mass Spectrometry; Uridine; Wastewater; Water Pollutants, Chemical | 2020 |
Use of Uridine Triacetate to Reverse Severe Persistent Myelosuppression Following 5-fluorouracil Exposure in a Patient With a c.557A>G Heterozygous DPYD Variant.
Topics: Acetates; Fluorouracil; Humans; Neoplasms; Uridine | 2021 |
A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Mice; Microbubbles; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome; Uridine | 2021 |
Endogenous metabolic markers for predicting the activity of dihydropyrimidine dehydrogenase.
Topics: Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Male; Polymorphism, Single Nucleotide; Uridine | 2022 |