uridine has been researched along with floxuridine in 178 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 133 (74.72) | 18.7374 |
| 1990's | 27 (15.17) | 18.2507 |
| 2000's | 10 (5.62) | 29.6817 |
| 2010's | 8 (4.49) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Wilson, BG | 1 |
| Harris, G; Olsen, I; Walford, EM | 1 |
| Aurias, A; Dutrillaux, B; Fosse, AM | 1 |
| Irvin, AD; Stagg, DA | 1 |
| Pfefferkorn, ER; Pfefferkorn, LC | 1 |
| Baserga, R; Chang, SD; Schiaffonati, L; Tsutsui, Y | 1 |
| Beránek, J; Hrebabecký, H | 1 |
| Jackson, RC | 1 |
| Danhauser, L; Rustum, YM; Wang, G | 1 |
| Houghton, JA; Houghton, PJ; Wooten, RS | 1 |
| Bowen, D; Diasio, RB; Goldman, ID | 1 |
| Bond, CW; Swim, HE | 1 |
| Hanas, RJ; Tlsty, TD; Wilkinson, DS | 1 |
| Czerwiński, RM; Kowalska-Loth, B; Staron, K | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Aran, JM; Plagemann, PG | 1 |
| Barberi-Heyob, M; Merlin, JL; Webér, B | 1 |
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| Kitada, S; Lee, DA; Shapourifar-Tehrani, S; Stephenson, TR | 1 |
| Lee, DA; Moore, JJ; Shapourifar-Tehrani, S; Smyth, RJ | 1 |
| De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| Kumar, AM; Nayak, R | 1 |
| Cha, S; Darnowski, JW; el Kouni, MH; Naguib, FN; Park, KS; Soong, SJ | 1 |
| Hirose, S; Kito, M; Takeshima, S; Urakami, K; Yoshida, S | 1 |
| Ishii, K | 1 |
| Andersson, HC | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY | 1 |
| Dominski, Z; Kole, R; Shukla, RR; Sierakowska, H | 1 |
| Ho, DH; Kamiya, K; Nakamura, T; Sasaki, K; Tsutani, H; Uchida, M; Yoshimura, T | 1 |
| Lycke, E; Svennerholm, B; Ziegler, R | 1 |
| Boothman, DA; Greer, SB; Mekras, JA | 1 |
| Abrams, DN; Knaus, EE; Lee, YW; Mercer, JR; Wiebe, LI | 1 |
| Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L | 2 |
| Heath, TD; Lewis, GP; Lopez, NG; Stern, WH | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 1 |
| Hara, Y; Karube, Y; Kono, A; Matsushima, Y; Sugata, S | 1 |
| Bollag, W; Hartmann, HR | 1 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, C | 1 |
| Blumenkranz, MS; Hajek, AS; Hartzer, MK | 1 |
| Boothman, DA; Briggle, TV; Greer, S | 1 |
| Au, JL; Bramer, SL; Wientjes, MG | 1 |
| Aigner, KR; Danenberg, PV; Link, KH; Peschau, K; Schwemmle, K; Warthona, M | 1 |
| Belt, JA; Noel, LD | 1 |
| Laurensse, EJ; Peters, GJ; Pinedo, HM | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Matsuzawa, T; Murakami, M | 1 |
| Lin, F; Warren, BS; Williams, WM | 1 |
| Bean, B; Tomasz, A | 1 |
| Rothstein, H; Stein, GS | 1 |
| Frankel, J | 1 |
| Franceschini, P; Pellegrino, M; Salzman, NP | 1 |
| Kates, JR; McAuslan, BR | 2 |
| Beridze, TG; Cherkashina, NA; Odintsova, MS; Sissakian, NM | 1 |
| Emerson, TR; Swan, RJ; Ulbricht, TL | 1 |
| Cohen, EP | 1 |
| Woodson, B | 1 |
| Lang, A; Nitsan, J | 1 |
| Wolberg, WH | 1 |
| Klímek, M; Vlasinová, M | 1 |
| Glick, JL; Sahler, C | 1 |
| Mendelsohn, J; Moore, DE; Salzman, NP | 1 |
| Hunter, JA; Paul, J | 1 |
| Dahl, R; Kates, J; Mielke, M | 1 |
| Braun, R; Wili, H | 1 |
| Seeber, S; Warnecke, P; Weitzel, G | 1 |
| Gontcharoff, M; Rao, B | 2 |
| Babcock, KL; Goodman, EM; Rusch, HP; Sauer, HW | 1 |
| Kotomin, AV; Neĭfakh, AA | 1 |
| Ahnström, G; Ehrenberg, L; Hussain, S; Nataraian, AT | 1 |
| Cremer, NE; Lennette, EH; Oshiro, LS; Teitz, Y | 1 |
| Flickinger, RA; Remington, JA | 1 |
| Everson, R; Hall, TC; Kessel, D | 1 |
| Ginsberg, HS; Lucas, JJ | 1 |
| Hof, JV; Kovacs, CJ | 1 |
| Archard, LC; Williamson, JD | 1 |
| Bruns, R; Hall, TC; Kessel, D | 1 |
| Rosner, A; Yagil, E | 1 |
| Moner, JG; Plunkett, W | 1 |
| Fox, BW; Perkins, JP; Prusoff, WH | 1 |
| Beck, CF; Ingraham, JL; Neuhard, J; Thomassen, E | 1 |
| Plattner-Schobel, R; Remy, U; Sachsenmaier, W | 1 |
| Brachet, J; O'Dell, D; Steinert, G; Tencer, R | 1 |
| Avery, GB; Hunt, CV | 1 |
| Conkie, D; Drewienkiewicz, CE; Lanyon, WG; Nicol, AG; Paul, J; Williamson, R | 1 |
| Aingorn, ED; Akifjev, AP | 1 |
| Fujiwara, Y | 1 |
| Williams, JP | 1 |
| Zeuthen, E | 1 |
| Carter, BJ; Dolin, R; Garrison, J; Koczot, FJ; Rose, JA | 1 |
| Drake, JW; Green, RR; Ripley, LS; Smith, MD | 1 |
| Burroughs, AL; Cardinet, GH | 1 |
| Gunderina, LI | 1 |
| Clissold, P; Cole, RJ | 1 |
| Topper, YJ; Vonderhaar, BK | 1 |
| Bradley, MO | 1 |
| McDougald, LR; Ouellette, CA; Strout, RG | 1 |
| Bertinchamps, AJ; Mathur-De Vré, R | 1 |
| Blandin, M; Catlin, JC; Guschlbauer, W | 1 |
| Chun, LL; Patterson, PH | 1 |
| Heidelberger, C; Khwaja, TA | 1 |
| Pétursson, G; Weil, R | 1 |
| Heidelberger, C; Umeda, M | 1 |
| Gentry, GA; Hyde, JM; O'Callaghan, DJ; Randall, CC | 1 |
| Verwoerd, DW | 1 |
| Goldstein, D; Hudson, J; Weil, R | 1 |
| Baluda, MA; Brodetsky, AM; Knudson, AG | 1 |
| Berthod, H; Pullman, B | 1 |
| Maley, F; Maley, GF | 1 |
| Anderson, CW; Gesteland, RF | 1 |
| McKerlie, L; Salzman, LA; White, WL | 1 |
| Notkins, AL; Yamazaki, S | 1 |
| Sokol, F; Tan, KB | 1 |
| Kirk-Bell, S; Lehmann, AR; Shall, S; Whish, WJ | 1 |
| Kulikowski, TD; Shugar, D | 1 |
| Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG | 1 |
| Kauffman, SA; Shymko, RM | 1 |
| Franze-Fernandez, MT; Iapalucci-Espinoza, S | 1 |
| Cadman, E; Grant, S | 1 |
| Ardalan, B; Cooney, D; Lippman, M; Macdonald, J; Schein, P | 1 |
| Polak, A | 1 |
| Armstrong, RD; Connolly, KM; Diasio, RB; Kaplan, AM | 1 |
| Abe, Y; Endo, S; Fukuda, H; Ido, T; Ishiwata, K; Kubota, K; Matsuzawa, T; Sato, T; Takahashi, T; Yamada, K; Yoshioka, S | 1 |
| Ido, T; Ishiwata, K; Kawashima, K; Murakami, M; Takahashi, T | 1 |
| Hoshi, A; Iigo, M | 1 |
| Briggle, TV; Greer, S; Mekras, JA; Perez, LM | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Iwata, R; Kameyama, M; Matsuzawa, T; Monma, M; Takahashi, T; Tsurumi, Y | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Fukuoka, K; Ishitsuka, H; Itoga, A; Maruyama, HB; Miwa, M; Takemoto, K | 1 |
| Hoshi, A; Kanzawa, F; Kuretani, K | 3 |
| Hoshi, A; Kuretani, K; Yoshida, M | 1 |
| Heidelberger, C; Mulkins, MA | 1 |
| Gmeiner, WH; Pon, RT; Sahasrabudhe, PV | 1 |
| Barberi-Heyob, M; de Bruijn, EA; Dittrich, C; Guillemin, F; Luporsi, E; Merlin, JL; Weber, B | 1 |
| Inui, N; Sato, S; Takizawa, H | 1 |
| Inaba, M; Mitsuhashi, J | 1 |
| Maeda, M; Saneyoshi, M; Tokuzen, R; Yamaguchi, T; Yoshida, M | 1 |
| Konishi, T; Ling, L; Maekawa, T; Ozaki, S; Uemura, A; Yamashita, K | 1 |
| Giacomini, KM; Gutierrez, MM | 1 |
| el Kouni, MH; el Kouni, MM; Naguib, FN | 1 |
| Eda, H; Fujimoto, K; Ishikawa, T; Ishitsuka, H; Ohiwa, T; Tanaka, Y; Tatsuno, K; Watanabe, S | 1 |
| Haba, S; Koga, M; Ozaki, S; Saeki, T; Suzuki, T; Yamamoto, M; Yasusa, T | 1 |
| Ishida, R; Ito, S; Koda, A; Mori, H; Nagai, H; Nakayama, K | 1 |
| Bertino, JR | 1 |
| Inaba, M; Mitsuhashi, J; Naoe, Y | 1 |
| Nakagawa, T; Sawai, Y; Yamaoka, K | 1 |
| Alberch, J; Checa, N; Gratacòs, E | 1 |
| Cass, CE; Lang, TT; Selner, M; Young, JD | 1 |
| ERLANDSON, M; HARTMANN, JR; MURPHY, ML; ORIGENES, ML; SITARZ, A | 1 |
| HARRIS, DR; MACINTYRE, WM | 1 |
| RUSCH, HP; SACHSENMAIER, W | 1 |
| DUBBS, DR; KIT, S | 1 |
| HODAS, S; YOUNG, CW | 1 |
| LOH, PC; PAYNE, FE | 1 |
| BASCH, RS; KARNOFSKY, DA | 1 |
| Cass, CE; Lang, TT; Young, JD | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Agarwal, R; Ardalan, B; Patel, M | 1 |
| López-Rivas, A; Muñoz-Pinedo, C; Robledo, G | 1 |
| Cao, D; Pizzorno, G | 1 |
| Cricca, S; de Bruin, M; Laan, AC; Peters, GJ; Temmink, OH; Turksma, AW | 1 |
| Beumer, JH; Doroshow, JH; Egorin, MJ; Lenz, HJ; Newman, EM; Parise, RA; Synold, TW | 1 |
| Dittmar, K; Heiss, WD; Jacob, AJ; Jacobs, AH; Knaus, EE; Li, HF; Moharram, S; Stöckle, M; Wiebe, LI; Winkeler, A | 1 |
| Chabner, BA; Drake, JC; Fuller, RW; Hande, KR | 1 |
| Begley, TP; Bu, W; Ealick, SE; O'Leary, SE; Paul, D; Rajashankar, K; Sanders, JM; Settembre, EC; Toms, A | 1 |
| Chen, JH; Li, ZH; Lu, X; Ping, Y; Tang, GP; Wang, QQ; Xu, FJ; Yang, WT | 1 |
| Doseth, B; Kavli, B; Krokan, HE; Pettersen, HS; Slupphaug, G; Svaasand, EK; Vågbø, CB; Visnes, T | 1 |
| Baek, IH; Kim, MS; Kwon, KI; Lee, BY | 1 |
| Lin, G; Liu, R; Xu, H | 1 |
| He, S; Jiang, Y; Pu, K; Xie, C | 1 |
| CRUZ, O; GRIESBACH, L; GRUNBERG, E; HEIDELBERGER, C; SCHNITZER, RJ | 1 |
| BOLAFFI, JL; CHEONG, L; EIDINOFF, ML; KNOLL, JE; RICH, MA | 1 |
3 review(s) available for uridine and floxuridine
| Article | Year |
|---|---|
Synchronization of the Tetrahymena cell cycle.
Topics: Animals; Antimalarials; Carbon Isotopes; Cell Division; Cell Nucleus; Culture Media; DNA; DNA Replication; Floxuridine; Hot Temperature; Methotrexate; Morphogenesis; Nucleosides; Protein Biosynthesis; Temperature; Tetrahymena; Tetrahymena pyriformis; Thymidine; Time Factors; Transcription, Genetic; Tritium; Uridine | 1971 |
Chemotherapy of colorectal cancer: history and new themes.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Floxuridine; Fluorouracil; History, 20th Century; Humans; Prodrugs; Uridine | 1997 |
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
Topics: Animals; Antimetabolites, Antineoplastic; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Neoplasms; Pyrimidines; Uridine; Uridine Phosphorylase | 2004 |
2 trial(s) available for uridine and floxuridine
| Article | Year |
|---|---|
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Deoxycytidine; DNA Modification Methylases; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Reproducibility of Results; Tandem Mass Spectrometry; Tetrahydrouridine; Uridine | 2008 |
173 other study(ies) available for uridine and floxuridine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
DNA replication in the amphibia.
Topics: Amphibians; Animals; Anura; Autoradiography; Bufonidae; DNA Replication; Floxuridine; Isotope Labeling; Ranidae; Thymidine; Tritium; Triturus; Uridine | 1975 |
The effects of thymidine and its analogues on the differentiation of antibody-forming cells.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; Bromodeoxyuridine; Cell Differentiation; Cells, Cultured; Dactinomycin; DNA; Female; Floxuridine; Leucine; Male; Puromycin; Rabbits; RNA; Sheep; Spleen; Thymidine; Tritium; Uridine | 1975 |
[Differentiation of the mechanisms inducing segmentation and asymetry of chromatids after treatment with 5-bromodeoxyuridine].
Topics: Bromodeoxyuridine; Chromatin; Chromosome Aberrations; Chromosomes; Floxuridine; Humans; Lymphocytes; Mitosis; Protein Conformation; Thymidine; Uracil Nucleotides; Uridine | 1976 |
Theileria parva: purine and pyrimidine metabolism and the action of folate antagonists in parasitized bovine lymphoid cells.
Topics: Adenine; Aminopterin; Animals; Azaguanine; Cattle; Cells, Cultured; Culture Media; Eukaryota; Floxuridine; Folic Acid Antagonists; Guanine; Hypoxanthines; Lymphocytes; Methotrexate; Purines; Pyrimidine Nucleosides; Theileriasis; Thymidine; Uridine | 1977 |
Toxoplasma gondii: characterization of a mutant resistant to 5-fluorodeoxyuridine.
Topics: Animals; Cell Line; Deoxyuridine; DNA; Drug Resistance; Floxuridine; Fluorouracil; Genes; Mutation; RNA; Thymidine; Toxoplasma; Uridine | 1977 |
Effect of 5-bromodeoxyuridine on deoxyribonucleic acid-protein adducts induced by ultraviolet light on chromatin cells.
Topics: Bromodeoxyuridine; Cell Line; Centrifugation, Density Gradient; Chromatin; Chromosomal Proteins, Non-Histone; DNA; Dose-Response Relationship, Radiation; Floxuridine; Histones; Methods; Ultraviolet Rays; Uridine | 1978 |
5'-Halogeno-2',3'-cyclic sulphite isomers in the preparation of 5'-halogeno nucleosides. Synthesis of 5'-deoxyuridine and 5'-deoxy-5-fluorouridine.
Topics: Deoxyuridine; Floxuridine; Uridine | 1978 |
The regulation of thymidylate biosynthesis in Novikoff hepatoma cells and the effects of amethopterin, 5-fluorodeoxyuridine, and 3-deazauridine.
Topics: 3-Deazauridine; Animals; Cell Line; DNA, Neoplasm; Floxuridine; Liver Neoplasms, Experimental; Methotrexate; Thymidine; Thymidine Monophosphate; Thymine Nucleotides; Uridine | 1978 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine | 1979 |
Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine.
Topics: Animals; Body Weight; Digestive System; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Lethal Dose 50; Male; Mice; Mice, Inbred CBA; RNA; Time Factors; Uridine | 1979 |
Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.
Topics: Animals; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Chromatography, High Pressure Liquid; Deoxyuridine; Floxuridine; Fluorouracil; Kinetics; Mice; Thymidine; Uridine | 1979 |
Physiological characterization of temperature-sensitive mutants of mengovirus.
Topics: Animals; Carbon Radioisotopes; Cell Line; Centrifugation, Density Gradient; Cycloheximide; Dactinomycin; DNA-Directed RNA Polymerases; Floxuridine; Genetic Complementation Test; Hemagglutination Tests; Liver; Mengovirus; Mice; Mutagens; Mutation; Nitrosoguanidines; Protein Biosynthesis; RNA, Viral; Temperature; Tritium; Uridine; Viral Plaque Assay | 1975 |
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Floxuridine; Fluorouracil; In Vitro Techniques; Liver Neoplasms; Neoplasms, Experimental; RNA, Neoplasm; RNA, Ribosomal; Time Factors; Uridine | 1975 |
Effects of fluorodeoxyuridine and nalidixic acid on the activity of topoisomerase I in plasmodia of Physarum polycephalum.
Topics: Animals; DNA Topoisomerases, Type I; Floxuridine; Kinetics; Nalidixic Acid; Physarum polycephalum; RNA; Uridine | 1992 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
Nucleoside transport-deficient mutants of PK-15 pig kidney cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Line; Clone Cells; Cytarabine; DNA; Escherichia coli; Flow Cytometry; Floxuridine; Hypoxanthine; Hypoxanthines; Kidney; Kinetics; Membrane Proteins; Methotrexate; Mutation; Nucleoside Transport Proteins; Nucleosides; Plasmids; Recombinant Proteins; Swine; Thymidine; Transfection; Tubercidin; Uridine | 1992 |
Determination of 5-fluorouracil and its main metabolites in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Hydrogen-Ion Concentration; Phosphates; Potassium; Potassium Compounds; Spectrophotometry, Ultraviolet; Uridine | 1992 |
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
The effects of the fluorinated pyrimidines FUR, FUdR, FUMP, and FdUMP on human Tenon's fibroblasts.
Topics: Adenosine; Cell Division; Cell Survival; Culture Techniques; Dose-Response Relationship, Drug; Eye; Fibroblasts; Floxuridine; Humans; Trypan Blue; Uracil Nucleotides; Uridine | 1991 |
The effects of 5-fluorouridine, 5-fluorodeoxyuridine, and 5-fluorodeoxyuridine monophosphate on rabbit tenon's capsule fibroblasts in vitro.
Topics: Adenosine; Animals; beta-N-Acetylhexosaminidases; Cell Adhesion; Cell Count; Cell Division; Cell Line; DNA; Fascia; Fibroblasts; Floxuridine; Humans; Rabbits; Uridine | 1991 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Thymidine Phosphorylase; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
Glycosidic bond cleavage of 5-fluoro-2'-deoxyuridine and 5-fluorouridine by amino acyl-tRNA synthetases.
Topics: Animals; Chromatography, Thin Layer; Cytoplasm; Floxuridine; Glycoside Hydrolases; Glycosides; Hydrolysis; Liver; Lysine-tRNA Ligase; Rats; Rats, Inbred Strains; Uridine | 1990 |
Circadian rhythm of hepatic uridine phosphorylase activity and plasma concentration of uridine in mice.
Topics: Animals; Circadian Rhythm; Female; Floxuridine; Fluorouracil; Liver; Male; Mice; Uridine; Uridine Phosphorylase | 1990 |
High-performance liquid chromatography with chemiluminescence detection of serum levels of pre-column derivatized fluoropyrimidine compounds.
Topics: Chromatography, High Pressure Liquid; Coumarins; Floxuridine; Fluorine; Fluorouracil; Humans; Molecular Structure; Pyrimidines; Tegafur; Umbelliferones; Uridine | 1990 |
Isolation of thymidine-requiring variants from rat nerve-like cells.
Topics: Amides; Animals; Bucladesine; Cell Differentiation; Cell Division; Cell Fusion; Cell Line; Floxuridine; Humans; Neurons; Pyrazoles; Rats; Ribonucleosides; Ribose; Thymidine; Thymidine Kinase; Thymidylate Synthase; Uridine | 1990 |
Sister chromatid exchanges in Tradescantia paludosa.
Topics: Azure Stains; Bromodeoxyuridine; Floxuridine; Magnoliopsida; Microscopy, Fluorescence; Mitotic Index; Sister Chromatid Exchange; Staining and Labeling; Uridine | 1985 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Messenger; RNA, Ribosomal; Sarcoma 180; Uridine | 1987 |
Inhibition of pre-mRNA splicing by 5-fluoro-, 5-chloro-, and 5-bromouridine.
Topics: Antiviral Agents; Bromouracil; DNA; Exons; Floxuridine; Genes; Genetic Complementation Test; Globins; HeLa Cells; Humans; Plasmids; RNA Precursors; RNA Splicing; RNA, Small Nuclear; Templates, Genetic; Transcription, Genetic; Uridine | 1989 |
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia L1210; Mice; Tumor Cells, Cultured; Uridine | 1989 |
Herpes simplex virus infection of the rat sensory neuron. Effects of interferon on cultured cells.
Topics: Animals; Cells, Cultured; Cytarabine; Floxuridine; Interferon Type I; Neurons; Rats; Simplexvirus; Uridine; Virus Replication | 1989 |
Use of 5-trifluoromethyldeoxycytidine and tetrahydrouridine to circumvent catabolism and exploit high levels of cytidine deaminase in tumors to achieve DNA- and target-directed therapies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Cytidine Deaminase; Deoxycytidine; DNA; Female; Floxuridine; Fluorouracil; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Nucleoside Deaminases; Tetrahydrouridine; Thymidylate Synthase; Trifluridine; Uridine | 1985 |
Tumour uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models. IX. Radiolabelled 1-(2'-fluoro-2'-deoxy-beta-D-ribofuranosyl)uracil and 1-(2'-chloro-2'-deoxy-beta-D-ribofuranosyl)uracil.
Topics: Animals; Carbon Radioisotopes; Carcinoma 256, Walker; Chlorine; Deoxyuridine; Floxuridine; Lung Neoplasms; Mice; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Uracil; Uridine | 1986 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; Rectal Neoplasms; Uridine | 1986 |
Fluoropyrimidine treatment of ocular cicatricial disease.
Topics: Animals; Cell Division; Cicatrix; Eye Diseases; Fibroblasts; Floxuridine; Fluorouracil; Osmolar Concentration; Rabbits; Skin; Uridine | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Partial purification of a thymidine phosphorylase from human gastric cancer.
Topics: Floxuridine; Humans; In Vitro Techniques; Pentosyltransferases; Stomach Neoplasms; Thymidine; Thymidine Phosphorylase; Uridine | 1986 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung Neoplasms; Male; Mice; Rats; Rats, Inbred Strains; Sarcoma 180; Thymidine; Uridine | 1986 |
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Topics: Animals; Body Temperature Regulation; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Hematopoiesis; Leukocyte Count; Mice; Uridine | 1986 |
Selection of therapeutic agents for intraocular proliferative disease. II. Differing antiproliferative activity of the fluoropyrimidines.
Topics: Animals; Antineoplastic Agents; Cattle; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eye Neoplasms; Floxuridine; Flucytosine; Fluorouracil; Humans; Uridine | 1987 |
Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma.
Topics: Animals; Antimetabolites; Deoxycytidine; Female; Floxuridine; Fluorouracil; Lung Neoplasms; Mice; Tetrahydrouridine; Uridine | 1987 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Rectal Neoplasms; Uridine | 1987 |
Effect of uridine coadministration on 5'-deoxy-5-fluorouridine disposition in rats.
Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Floxuridine; Injections, Intravenous; Intestinal Absorption; Metabolic Clearance Rate; Rats; Rats, Inbred F344; Uridine | 1988 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Rectal Neoplasms; Time Factors; Tumor Cells, Cultured; Uridine | 1988 |
Isolation and characterization of a mutant of L1210 murine leukemia deficient in nitrobenzylthioinosine-insensitive nucleoside transport.
Topics: Animals; Biological Transport; Carrier Proteins; Cytarabine; Floxuridine; Inosine; Leukemia L1210; Membrane Proteins; Mice; Mutation; Nucleoside Transport Proteins; Nucleosides; Thioinosine; Thymidine; Tubercidin; Tumor Cells, Cultured; Uridine | 1988 |
A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography.
Topics: Cell Line, Transformed; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Kinetics; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured; Uracil; Uridine | 1988 |
Studies on 18F-labeled pyrimidines III. Biochemical investigation of 18F-labeled pyrimidines and comparison with 3H-deoxythymidine in tumor-bearing rats and mice.
Topics: Animals; Floxuridine; Fluorouracil; Iron Radioisotopes; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Pyrimidines; Radionuclide Imaging; Rats; Thymidine; Tissue Distribution; Tritium; Uridine | 1985 |
Gas-liquid chromatographic analysis of fluoropyrimidine nucleosides and fluorouracil in plasma and urine.
Topics: Animals; Chromatography, Gas; Chromatography, Ion Exchange; Dogs; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kidney; Kinetics; Uridine | 1985 |
5-Fluoropyrimidine-resistant mutants of pneumococcus.
Topics: Carbon Isotopes; Chromatography, Thin Layer; Cytosine; Deoxyribonucleosides; Drug Resistance, Microbial; Floxuridine; Fluorine; Fluorouracil; Mutation; N-Glycosyl Hydrolases; Pentosyltransferases; Phosphoric Monoester Hydrolases; Phosphotransferases; Pyrimidines; Ribonucleosides; Streptococcus pneumoniae; Transformation, Genetic; Uridine | 1973 |
Synthesis of macromolecules in epithelial cells of the cultured amphibian lens. IV. Requirement of DNA replication for the synthesis of RNA and protein during the "G2" period of the cell cycle.
Topics: Animals; Anura; Culture Techniques; DNA Replication; Epithelium; Floxuridine; Lens, Crystalline; Mitosis; Nucleosides; Protein Biosynthesis; RNA; Templates, Genetic; Time Factors; Tritium; Uridine | 1969 |
The effect of nucleic acid antagonists on cell division and oral organelle development in Tetrahymena pyriformis.
Topics: Antimetabolites; Cell Division; Dactinomycin; Floxuridine; In Vitro Techniques; Organoids; Phenylalanine; Tetrahymena; Uridine | 1965 |
Biochemical changes in phytohemagglutinin stimulated human lymphocytes.
Topics: Carbon Isotopes; DNA; Floxuridine; Humans; Lectins; Lymphocytes; RNA; Uridine | 1966 |
Regulation of virus-induced deoxyribonucleases.
Topics: Bromodeoxyuridine; Deoxyribonucleases; Enzyme Induction; Floxuridine; HeLa Cells; Poxviridae; RNA, Messenger; Thymidine Kinase; Uridine | 1966 |
The effect of nucleic acid synthesis inhibitors on the chlorophyll formation by etiolated bean leaves.
Topics: Azaguanine; Chlorophyll; Dactinomycin; Floxuridine; Fluorouracil; In Vitro Techniques; Mitomycins; Plants, Edible; Thiouracil; Thymidine; Uridine | 1966 |
Optical rotatory dispersion of nucleic acid derivatives. 8. The conformation of pyrimidine nucleosides in solution.
Topics: Chemical Phenomena; Chemistry, Physical; Floxuridine; Nucleosides; Pyrimidines; Solutions; Thymidine; Uridine | 1967 |
Conversion of non-immune cells into antibody-forming cells by RNA.
Topics: Animals; Antibody Formation; Antigen-Antibody Reactions; Erythrocytes; Floxuridine; Hemolysin Proteins; Kinetics; Mice; RNA; Spleen; Temperature; Tritium; Uridine | 1967 |
Vaccinia mRNA synthesis under conditions which prevent uncoating.
Topics: Cycloheximide; DNA, Viral; Floxuridine; HeLa Cells; Phosphorus Isotopes; Puromycin; Radiation Effects; RNA, Messenger; RNA, Viral; Thymidine; Ultraviolet Rays; Uridine; Vaccinia virus; Viral Proteins | 1967 |
Relations among cell growth, DNA synthesis, and gibberellin action.
Topics: Carbon Isotopes; Chloramphenicol; Dactinomycin; DNA; Ethanol; Floxuridine; Gibberellins; Methotrexate; Mitomycins; Plants, Edible; Puromycin; RNA; Thymidine; Tritium; Uridine | 1967 |
Determinants of human tumor sensitivity to fluorinated pyrimidine chemotherapy.
Topics: DNA, Neoplasm; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Ligases; Neoplasm Metastasis; Neoplasms; Phosphotransferases; Thymidine; Thymidine Kinase; Uracil Nucleotides; Uridine | 1967 |
Biologically significant doses of U.V. light and synthesis of DNA, RNA, and proteins in L-cells.
Topics: Carbon Isotopes; DNA; Floxuridine; In Vitro Techniques; L Cells; Lysine; Protein Biosynthesis; Proteins; Radiometry; RNA; Thymidine; Tritium; Ultraviolet Rays; Uridine; Valine | 1967 |
Specific metabolic changes in DNA-treated L1210 leukemia cells.
Topics: Animals; Carbon Isotopes; Culture Techniques; Dactinomycin; DNA; DNA, Bacterial; DNA, Neoplasm; Escherichia coli; Floxuridine; Leukemia L1210; Lysine; Mice; Puromycin; RNA, Neoplasm; Thymidine; Thymus Gland; Uridine | 1967 |
Separation of isolated Chinese hamster metaphase chromosomes into three size-groups.
Topics: Animals; Autoradiography; Carbon Isotopes; Centrifugation, Density Gradient; Chromosomes; Cricetinae; Culture Techniques; Densitometry; DNA; Floxuridine; Hot Temperature; Karyotyping; Mitosis; Proteins; RNA; Thymidine; Tritium; Uridine | 1968 |
DNA synthesis is essential for increased haemoglobin synthesis in response to erythropoietin.
Topics: Animals; Colchicine; Culture Techniques; Dactinomycin; DNA; DNA Replication; Erythropoietin; Fetus; Floxuridine; Genetic Code; Hemoglobins; Liver; Mice; Puromycin; Stimulation, Chemical; Thymidine; Tritium; Uridine | 1968 |
Synthesis and intracellular localization of vaccinia virus deoxyribonucleic acid-dependent ribonucleic acid polymerase.
Topics: Animals; Cattle; Centrifugation, Density Gradient; Cytoplasm; Deoxyribonucleases; DNA; DNA Replication; DNA, Viral; Floxuridine; HeLa Cells; Radiometry; RNA Nucleotidyltransferases; Sucrose; Surface-Active Agents; Thymidine; Tritium; Uridine; Vaccinia virus | 1968 |
Time sequence of DNA replication in Physarum.
Topics: Bromodeoxyuridine; Carbon Isotopes; Centrifugation, Density Gradient; DNA Replication; Floxuridine; Genetics, Microbial; Leucine; Mitosis; Myxomycetes; Protein Biosynthesis; Spectrophotometry; Thymidine; Time Factors; Tritium; Uridine | 1969 |
[Comparative in vitro studies with 5-fluorouracil and some of its derivatives].
Topics: Acyltransferases; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell-Free System; Depression, Chemical; DNA Nucleotidyltransferases; DNA, Neoplasm; Floxuridine; Fluorine; Fluorouracil; In Vitro Techniques; Leucine; Neoplasm Proteins; Nucleotides; RNA, Neoplasm; Thymidine; Uridine | 1969 |
Functionality of newly synthesized DNA as related to RNA synthesis during mitotic cycle in Physarum polycephalum.
Topics: DNA; Floxuridine; Mitosis; Myxomycetes; RNA; Thymidine; Time Factors; Tritium; Uridine | 1969 |
Polyphosphate in the life cycle of Physarum polycephalum and its relation to RNA synthesis.
Topics: Chromatography; Culture Media; Cycloheximide; Dactinomycin; Depression, Chemical; DNA; Floxuridine; Light; Metabolism; Mitosis; Myxomycetes; Phosphates; Phosphorus Isotopes; Plant Proteins; Radiation Effects; RNA; Stimulation, Chemical; Time Factors; Uridine | 1969 |
[The effect of 5-fluoro-2-deoxyuridine on the development of the sea urchin in the presence of thymidine and uridine].
Topics: Animals; DNA; Echinodermata; Embryo, Nonmammalian; Floxuridine; RNA; Thymidine; Uridine | 1967 |
Relationship between protein synthesis and viral deoxyribonucleic acid synthesis.
Topics: Animals; Culture Techniques; Cycloheximide; Dactinomycin; DNA Nucleotidyltransferases; DNA Replication; DNA, Viral; Floxuridine; HeLa Cells; Poxviridae; Puromycin; RNA, Viral; Thymidine; Thymidine Kinase; Tritium; Uridine; Viral Proteins; Virus Cultivation | 1967 |
On the killing and mutagenic action in E. coli associated with the Auger effect during 125-I decay.
Topics: Escherichia coli; Floxuridine; Iodine Isotopes; Mutation; Radiation Genetics; Radiometry; Tritium; Uracil; Uridine | 1970 |
Release of C-type particles from normal rat thymus cultures and those infected with Moloney leukemia virus.
Topics: Animals; Biological Assay; Cell Line; Centrifugation, Density Gradient; Culture Techniques; Cytarabine; Dactinomycin; DNA, Viral; Floxuridine; Fluorescent Antibody Technique; Immune Sera; Mice; Microscopy, Electron; Moloney murine leukemia virus; Rats; RNA, Viral; Spectrum Analysis; Thymus Gland; Tritium; Ultraviolet Rays; Uridine; Viral Proteins | 1971 |
The time of DNA replication in the cell cycle in relation to RNA synthesis in frog embryos.
Topics: Animals; Anura; Autoradiography; Carbon Isotopes; Chromosomes; Culture Techniques; DNA Replication; Floxuridine; Germ Layers; Hydrolysis; Mitosis; Nucleosides; RNA; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Plasmacytoma; Thymidine Kinase; Transferases; Uridine | 1970 |
Synthesis of virus-specific ribonucleic acid in KB cells infected with type 2 adenovirus.
Topics: Adenoviridae; Carcinoma; Cell Line; Cell-Free System; Cells, Cultured; Centrifugation, Density Gradient; DNA Replication; DNA, Viral; Evaluation Studies as Topic; Floxuridine; Genetic Code; Genetics, Microbial; Humans; Methods; Mouth Neoplasms; Nucleic Acid Denaturation; Nucleic Acid Hybridization; RNA; RNA, Ribosomal; RNA, Viral; Sodium Hydroxide; Sucrose; Time Factors; Tritium; Uridine; Virus Replication | 1971 |
Mitotic delay and the regulating events of plant cell proliferation: DNA replication by a G1-S population.
Topics: Cesium Isotopes; DNA; DNA Replication; Floxuridine; Kinetics; Leucine; Mitosis; Plants; Protein Biosynthesis; Puromycin; Radiation Effects; RNA; Thymidine; Time Factors; Tritium; Uridine | 1971 |
The effect of arginine deprivation on the replication of vaccinia virus.
Topics: Animals; Arginine; Carbon Isotopes; Cattle; Centrifugation, Density Gradient; Culture Media; DNA; Floxuridine; HeLa Cells; Immune Sera; Leucine; Phenylalanine; Potassium; Protein Biosynthesis; RNA; Tartrates; Thymidine; Tritium; Uridine; Vaccinia virus; Virus Replication | 1971 |
Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias.
Topics: Animals; Antineoplastic Agents; Biodegradation, Environmental; Biological Transport; Cell Line; Cell Survival; Cells, Cultured; Deoxyuridine; DNA Replication; DNA, Neoplasm; Drug Resistance; Floxuridine; Fluorine; Fluorouracil; Leukemia, Experimental; Mice; Neoplasm Transplantation; Pentosyltransferases; Phosphotransferases; Uridine | 1971 |
Phosphorolysis of 5-fluoro-2'-deoxyuridine in Escherichia coli and its inhibition by nucleosides.
Topics: Culture Media; Deoxyribonucleosides; Escherichia coli; Floxuridine; Nucleosides; Pentosyltransferases; Ribonucleosides; Thymidine; Tritium; Uridine | 1971 |
The role of uridine-cytidine kinase in the regulation of pyrimidine ribonucleotide synthesis in Tetrahymena pyriformis GL.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Paper; Cytidine; Deoxyribonucleosides; Deoxyribonucleotides; Deoxyuridine; Enzyme Activation; Feedback; Floxuridine; Guanosine Triphosphate; Kinetics; Magnesium; Molecular Weight; Nucleotides; Phosphotransferases; Pyrimidine Nucleotides; Ribonucleotides; Tetrahymena pyriformis; Tritium; Uridine | 1971 |
Inhibitory action of thymine ribonucleoside and other pyrimidine derivatives on the cleavage of 5-iodo-deoxy-uridine by mouse-liver extract.
Topics: Animals; Chromatography, Thin Layer; Deoxyribonucleosides; Depression, Chemical; Female; Floxuridine; Hydrogen-Ion Concentration; Idoxuridine; Iodine Isotopes; Kinetics; Liver; Mice; Nucleosides; Pentosyltransferases; Pyrimidines; Rats; Ribonucleosides; Thymidine; Thymine; Uracil; Uridine | 1970 |
Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.
Topics: Aminohydrolases; Cytidine; Cytosine; Deoxyuridine; Floxuridine; Flucytosine; Fluorouracil; Genetics, Microbial; Genotype; Mutation; Nucleosides; Nucleotidyltransferases; Pentosyltransferases; Phosphotransferases; Pyrimidines; Salmonella typhimurium; Thymidine; Uracil; Uracil Nucleotides; Uridine | 1972 |
Initiation of synchronous mitosis in Physarum polycephalum. A model of the control of cell division in eukariots.
Topics: Cell Fusion; Depression, Chemical; DNA; DNA Replication; Floxuridine; Mitosis; Models, Biological; Myxomycetes; Periodicity; RNA, Messenger; Ultraviolet Rays; Uridine | 1972 |
Cleavage nucleoli and ribosomal RNA synthesis in sea urchin eggs.
Topics: Animals; Autoradiography; Cell Nucleolus; Female; Floxuridine; Microscopy, Electron; Ovum; RNA, Ribosomal; Sea Urchins; Tritium; Uridine | 1972 |
Dependence of the nucleolar structure on DNA and RNA synthesis.
Topics: Cell Division; Cell Nucleolus; Chromatin; Culture Techniques; DNA; DNA Replication; Floxuridine; Microscopy, Electron; Mitosis; Myxomycetes; Plasmodium; Radioisotopes; RNA; Thymidine; Time Factors; Tritium; Uridine | 1972 |
Giant cell formation in ectopic mouse trophoblast.
Topics: Animals; Autoradiography; Colchicine; Cycloheximide; Dactinomycin; DNA; Female; Floxuridine; Leucine; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mitosis; Ovum; Placenta; Protein Biosynthesis; RNA; Thymidine; Time Factors; Transplantation, Homologous; Tritium; Trophoblasts; Uridine | 1972 |
Characteristics of erythropoietin-induced RNA from foetal mouse liver erythropoietic cell cultures and the effects of 5-fluorodeoxyuridine.
Topics: Animals; Autoradiography; Cells, Cultured; Chemical Phenomena; Chemistry; DNA; Electrophoresis, Polyacrylamide Gel; Erythropoietin; Female; Fetus; Floxuridine; Heme; Iron Isotopes; Kinetics; Liver; Mice; Phosphorus Isotopes; Pregnancy; RNA; RNA, Ribosomal; Tritium; Uridine | 1972 |
DNA synthesis related to genome activation in human lymphocytes cultured in vitro.
Topics: Autoradiography; Chromosome Aberrations; Chromosomes; Colchicine; Dactinomycin; DNA; Female; Floxuridine; Humans; Lymphocyte Activation; Lymphocytes; Male; Mitosis; Thymidine; Tritium; Uracil; Uridine | 1972 |
Characteristics of DNA synthesis following ultraviolet light irradiation in mouse L cells. Postreplication repair.
Topics: Animals; Caffeine; Carbon Isotopes; Cell Line; Centrifugation, Density Gradient; Clone Cells; DNA; DNA Repair; DNA Replication; DNA, Single-Stranded; Floxuridine; L Cells; Mice; Molecular Weight; Radiation Effects; Sucrose; Thymidine; Tritium; Ultraviolet Rays; Uridine | 1972 |
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Fetus; Floxuridine; Fluorine; Fluorouracil; Mice; Mice, Inbred Strains; Pregnancy; Rats; Thymidine; Time Factors; Tritium; Uridine | 1971 |
Separate helper functions provided by adenovirus for adenovirus-associated virus multiplication.
Topics: Adenoviridae; Carcinoma; Cell Line; DNA, Viral; Floxuridine; Helper Viruses; Humans; Kinetics; Mouth Neoplasms; RNA, Viral; Satellite Viruses; Thymidine; Tritium; Uridine; Virus Replication | 1973 |
Thymineless mutagenesis in bacteriophage T4.
Topics: Adenine Nucleotides; Alleles; Bromodeoxyuridine; Coliphages; Cytosine Nucleotides; DNA Nucleotidyltransferases; DNA Repair; DNA, Bacterial; Escherichia coli; Floxuridine; Guanine Nucleotides; Mutation; Recombination, Genetic; Temperature; Thymidine; Thymidylate Synthase; Thymine; Thymine Nucleotides; Uridine | 1973 |
A small intranuclear virus recovered from lymphatic tissue of a bovine with malignant lymphoma.
Topics: Agglutination Tests; Animals; Autoradiography; Cattle; Cattle Diseases; Cell Line; Cell Nucleus; Chick Embryo; Cricetinae; Dactinomycin; Floxuridine; Fluorescent Antibody Technique; Kidney; Lymphoid Tissue; Lymphoma, Non-Hodgkin; Microscopy, Electron; Microscopy, Phase-Contrast; Oncogenic Viruses; Rabbits; RNA Viruses; Tritium; Uridine; Virus Cultivation | 1973 |
[H3-thymidine and H3-uridine incorporation into the cell nuclei of a primary rabbit kidney culture during the short-term action of 5-fluoro-2'-deoxyuridine].
Topics: Animals; Autoradiography; Cell Count; Cell Nucleus; Cells, Cultured; Culture Media; DNA; Floxuridine; Kidney; Photometry; Rabbits; Thymidine; Thymine Nucleotides; Time Factors; Tritium; Uridine | 1973 |
Regulation of ribosomal RNA synthesis during mammalian myogenesis in culture.
Topics: Animals; Cell Differentiation; Cell Division; Cell Fusion; Cells, Cultured; Creatine Kinase; Dactinomycin; Electrophoresis, Polyacrylamide Gel; Floxuridine; Kinetics; Methionine; Mice; Mitosis; Muscles; Muscular Dystrophies; RNA, Ribosomal; Tritium; Uridine | 1973 |
Critical cell proliferation as a prerequisite for differentiation of mammary epithelial cells.
Topics: Animals; Caseins; Cell Differentiation; Cytarabine; Epithelium; Estradiol; Female; Floxuridine; Glucosephosphate Dehydrogenase; Hydrocortisone; Insulin; Lactalbumin; Lactose Synthase; Mammary Glands, Animal; Mice; Mitosis; Pregnancy; Prolactin; Uridine | 1973 |
Arginase activity patterns and their regulation during embryonic development in liver and kidney.
Topics: Animals; Arginase; Cycloheximide; Cytidine; Dactinomycin; DNA; Enzyme Activation; Female; Floxuridine; Hydrocortisone; Kidney; Leucine; Liver; Mice; Organ Culture Techniques; Pregnancy; Proteins; Tritium; Uridine | 1973 |
Thymidylic acid synthesis in Eimeria tenella (Coccidia) cultured in vitro.
Topics: Autoradiography; Bromodeoxyuridine; Cell Nucleus; Cells, Cultured; Culture Media; Deoxyribonucleases; Depression, Chemical; Eimeria; Floxuridine; Kidney; Ribonucleases; Thymidine; Thymine Nucleotides; Tritium; Uridine | 1974 |
An NMR study of the relative interaction abilities of different pyrimidine nucleosides with serotonin.
Topics: Bromodeoxyuridine; Cytidine; Deoxycytidine; Floxuridine; Idoxuridine; Magnetic Resonance Spectroscopy; Pyrimidine Nucleosides; Serotonin; Thymidine; Uridine | 1974 |
Nucleoside conformations. 16. Nuclear magnetic resonance and circular dichroism studies on pyrimidine-2'-fluoro-2'-deoxyribonucleosides.
Topics: Chromatography, Paper; Chromatography, Thin Layer; Circular Dichroism; Crystallization; Deoxycytidine; Deoxyribonucleosides; Floxuridine; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrimidine Nucleosides; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiouracil; Uridine | 1974 |
The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons.
Topics: Acetylcholine; Animals; Catecholamines; Cells, Cultured; Choline; Cytarabine; Fibroblasts; Floxuridine; Ganglia, Autonomic; Glioma; Neurons; Rats; Sympathetic Nervous System; Uridine | 1974 |
Fluorinated pyrimidines. XXIX. Syntheses of 2',3'-dehydro-5-fluoro-2'-deoxyuridine and 2',3'-dideoxy-5-fluorouridine.
Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Escherichia coli; Floxuridine; HeLa Cells; Leukemia, Experimental; Liver Neoplasms; Mice; Sarcoma 180; Thymidine; Uridine | 1967 |
A study on the mechanism of polyoma-induced activation of the cellular DNA-synthesizing apparatus. Synchronization by FUdR of virus-induced DNA synthesis.
Topics: Autoradiography; Centrifugation, Density Gradient; Culture Techniques; Dactinomycin; Densitometry; DNA; DNA, Viral; Floxuridine; Fluorescent Antibody Technique; Hemagglutinins, Viral; Immune Sera; Microscopy, Electron; Nucleosides; Polyomavirus; Thymidine; Tritium; Ultracentrifugation; Uridine; Viral Proteins; Virus Replication | 1968 |
Comparative studies of fluorinated pyrimidines with various cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Culture Techniques; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Floxuridine; HeLa Cells; Leukemia, Experimental; Liver Neoplasms; Neoplasms, Experimental; Nucleosides; Phosphotransferases; Pyrimidines; RNA, Neoplasm; Thymidine; Thymidine Kinase; Uridine | 1968 |
Kinetics of viral deoxyribonucleic acid, protein, and infectious particle production and alterations in host macromolecular syntheses in equine abortion (herpes) virus-infected cells.
Topics: Abortion, Veterinary; Animals; Carbon Isotopes; Culture Techniques; Cycloheximide; Cytopathogenic Effect, Viral; DNA, Viral; Female; Fibroblasts; Floxuridine; Growth; Herpesviridae; Herpesviridae Infections; Horse Diseases; Horses; Kinetics; Leucine; Microscopy, Electron; Pregnancy; Protein Biosynthesis; RNA; Uridine; Viral Proteins; Virus Replication | 1968 |
Purification and characterization of bluetongue virus.
Topics: Animals; Bluetongue; Carbon Isotopes; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry, Physical; Cricetinae; Culture Techniques; Cytopathogenic Effect, Viral; Dactinomycin; Floxuridine; Hot Temperature; Kidney; L Cells; Mice; Nucleic Acid Denaturation; Phenylalanine; Phosphorus Isotopes; Reoviridae; RNA, Viral; Sheep; Sheep Diseases; Uridine; Virus Cultivation | 1969 |
A study on the transcription of the polyoma viral genome.
Topics: Centrifugation, Density Gradient; Culture Techniques; DNA, Viral; Floxuridine; Genetic Code; Genetics, Microbial; Kidney; Polyomavirus; RNA, Viral; Tritium; Uridine | 1970 |
Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine.
Topics: Animals; Antiviral Agents; Avian Leukosis Virus; Cell Division; Chick Embryo; Culture Techniques; DNA, Viral; Fibroblasts; Floxuridine; Methotrexate; RNA, Viral; Thymidine; Tritium; Uridine; Virus Replication | 1967 |
Molecular orbital calculations on the conformation of nucleic acids and their constituents. I. Conformational energies of beta-nucleosides with C(3')-and C(2')-endo sugars.
Topics: Adenine; Adenine Nucleotides; Bromine; Chemical Phenomena; Chemistry; Coenzymes; Cyclic AMP; Floxuridine; Glycosides; Guanine; Guanine Nucleotides; Isomerism; Mathematics; Nucleosides; Nucleotides; Pentoses; Purines; Pyrimidines; Ribose; Rotation; Thermodynamics; Thymine Nucleotides; Uracil Nucleotides; Uridine; Vitamin B 12; X-Ray Diffraction | 1971 |
Tetrahydrodeoxyuridylate: a potent inhibitor of deoxycytidylate deaminase.
Topics: Aminohydrolases; Animals; Carbon Isotopes; Chick Embryo; Chromatography, Ion Exchange; Chromatography, Paper; Cytosine Nucleotides; Deoxyribonucleases; Deoxyribonucleosides; Deoxyribonucleotides; Deoxyuridine; DNA; Electrophoresis; Floxuridine; Kinetics; Metabolism; Pancreas; Phosphoric Monoester Hydrolases; Ribonucleosides; Thymine Nucleotides; Uracil Nucleotides; Uridine; Venoms | 1971 |
Pattern of protein synthesis in monkey cells infected by simian virus 40.
Topics: Amino Acid Sequence; Animals; Autoradiography; Cell Line; Cytarabine; DNA Replication; DNA, Viral; Electrophoresis, Disc; Floxuridine; Haplorhini; Kidney; Methionine; Peptides; Phosphorus Isotopes; Simian virus 40; Sulfur Isotopes; Thymidine; Time Factors; Tritium; Trypsin; Uridine; Viral Proteins | 1972 |
Growth characteristics of Kilham rat virus and its effect on cellular cellular macromolecular synthesis.
Topics: Amino Acids; Animals; Antiviral Agents; Carbon Isotopes; Cell Line; Cells, Cultured; DNA Viruses; DNA, Neoplasm; DNA, Single-Stranded; DNA, Viral; Floxuridine; Neoplasm Proteins; Rats; RNA, Neoplasm; Thymidine; Time Factors; Tritium; Uridine; Viral Plaque Assay; Virus Replication; Wilms Tumor | 1972 |
Inhibition of replication of lactic dehydrogenase virus by actinomycin.
Topics: Animals; Culture Techniques; Cytarabine; Dactinomycin; DNA; Drug Resistance, Microbial; Floxuridine; Interferons; L Cells; L-Lactate Dehydrogenase; Mice; Mice, Inbred Strains; Newcastle disease virus; RNA; RNA Viruses; Thymidine; Time Factors; Tritium; Uridine; Vesicular stomatitis Indiana virus; Virus Diseases; Virus Replication | 1973 |
Enancement of uptake of Simian virus 40 by nuclei of permissive cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Culture Media; Cycloheximide; Cytarabine; Cytoplasm; Dactinomycin; DNA; Floxuridine; Haplorhini; Histones; Hydroxyurea; Kidney; Kinetics; Magnesium Sulfate; RNA; Simian virus 40; Thymidine; Tritium; Uridine | 1973 |
The relationship between cell growth, macromolecular synthesis and poly ADP-ribose polymerase in lymphoid cells.
Topics: Adenosine Diphosphate; Animals; Cell Division; Cell Line; Cell Nucleus; Cycloheximide; Dactinomycin; DNA; Floxuridine; Hydroxyurea; Lectins; Lymphocytes; Lymphoma; Mice; Mitomycins; NAD; Nucleotidyltransferases; Phenylalanine; Polynucleotide Ligases; Polynucleotides; Protein Biosynthesis; Stimulation, Chemical; Swine; Thymidine; Tritium; Uridine | 1974 |
Reaction of nucleosides with N-trimethylsilylimidazole: separation of TMS derivatives of anomeric pyrimidine nucleosides by gas-liquid chromatography.
Topics: Adenosine; Binding Sites; Chromatography, Gas; Chromatography, Thin Layer; Cytosine; Deoxyribonucleosides; Evaluation Studies as Topic; Floxuridine; Guanosine; Imidazoles; Isomerism; Kinetics; Methods; Molecular Conformation; Molecular Weight; Nucleic Acid Conformation; Pyrimidine Nucleosides; Silicon Dioxide; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Temperature; Time Factors; Uridine | 1974 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Mitotic delay following inhibition by 5'-fluorodeoxyuridine of S-phase in Physarum is not due to delay in termination of S-phase.
Topics: Cell Cycle; DNA; Floxuridine; Interphase; Kinetics; Mitosis; Physarum; Time Factors; Uridine | 1982 |
Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues.
Topics: Animals; Azaguanine; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricetinae; Floxuridine; Kidney; Ribosomal Proteins; RNA, Ribosomal; Toyocamycin; Transcription, Genetic; Uracil Nucleotides; Uridine; Uridine Triphosphate | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.
Topics: Breast Neoplasms; Cell-Free System; Cytosol; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; In Vitro Techniques; Phosphorylation; Uridine | 1981 |
Mode of action of 5-fluorocytosine and 5-fluorouracil in dematiaceous fungi.
Topics: Cytosine; Drug Resistance, Microbial; Floxuridine; Flucytosine; Fluorouracil; Mitosporic Fungi; RNA, Fungal; RNA, Ribosomal; Species Specificity; Uridine | 1983 |
Decreased immunosuppression associated with antitumor activity of 5-deoxy-5-fluorouridine compared to 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Survival; Female; Floxuridine; Fluorouracil; Immunosuppression Therapy; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrans; Thioglycolates; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. Tumor uptakes of 18F-5-fluorouracil, 18F-5-fluorouridine, and 18F-5-fluorodeoxyuridine in animals.
Topics: Animals; Autoradiography; Floxuridine; Fluorine; Fluorouracil; Liver Neoplasms, Experimental; Male; Radioisotopes; Rats; Rats, Inbred Strains; Tissue Distribution; Tomography, Emission-Computed; Uridine | 1983 |
Studies on 18F-labeled pyrimidines. II. Metabolic investigation of 18F-5-fluorouracil, 18F-5-fluoro-2'-deoxyuridine and 18F-5-fluorouridine in rats.
Topics: Animals; Bile; Floxuridine; Fluorine; Fluorouracil; Radioisotopes; Rats; Rats, Inbred Strains; Uridine | 1984 |
Effect of guanosine on antitumor activity of fluorinated pyrimidines against P 388 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Floxuridine; Fluorouracil; Guanosine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleosides; Uridine | 1984 |
Marked radiosensitization of cells in culture to X ray by 5-chlorodeoxycytidine coadministered with tetrahydrouridine, and inhibitors of pyrimidine biosynthesis.
Topics: Animals; Aspartic Acid; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Radiation; Floxuridine; Humans; Laryngeal Neoplasms; Mice; Organophosphorus Compounds; Phosphonoacetic Acid; Radiation-Sensitizing Agents; Tetrahydrouridine; Uridine | 1984 |
Syntheses of 18F-labeled pyrimidines and their usefulness for tumor imaging.
Topics: Animals; Chromatography, High Pressure Liquid; Floxuridine; Fluorine; Fluorouracil; Glioma; Liver Neoplasms, Experimental; Mammary Neoplasms, Experimental; Mice; Radioisotope Dilution Technique; Radioisotopes; Radionuclide Imaging; Rats; Uridine | 1984 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine | 1980 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransferases; Sarcoma 180; Tegafur; Thymidine; Uridine; Uridine Phosphorylase | 1980 |
Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Floxuridine; Leukemia L5178; Leukemia, Experimental; Male; Mice; Uridine | 1980 |
Mechanism of cytotoxicity of 5-fluorouracil: distinction between the irreversible cytotoxic effect of 5-fluorouridine and the reversible cytotoxic effect of 5-fluoro-2'-deoxyuridine on murine lymphoma L5178Y cells in culture.
Topics: Animals; Cell Division; Cell Line; Floxuridine; Fluorouracil; Leukemia, Experimental; Mice; Uridine | 1980 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Neoplasm Proteins; RNA, Neoplasm; Thymidylate Synthase; Uridine | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leukemia, Experimental; Mice; Uridine | 1980 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Mutation; Phenotype; Selection, Genetic; Uridine | 1982 |
Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.
Topics: Base Sequence; Binding Sites; Circular Dichroism; DNA; Drug Stability; Floxuridine; Molecular Sequence Data; Nucleic Acid Conformation; RNA; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics; Uridine | 1995 |
Evaluation of plasma 5-fluorouracil nucleoside levels in patients with metastatic breast cancer: relationships with toxicities.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Neoplasm Metastasis; Uridine | 1995 |
Mouse strain differences in induction of micronuclei by base analogues and nucleosides.
Topics: Adenine; Animals; Bromodeoxyuridine; Bromouracil; Cytarabine; Erythrocytes; Female; Floxuridine; Guanosine; Mercaptopurine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Micronucleus Tests; Mitogens; Nucleosides; Purines; Pyrimidines; Species Specificity; Thymidine; Uridine | 1993 |
Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells.
Topics: Cell Cycle; Cell Survival; Colorectal Neoplasms; DNA, Neoplasm; DNA, Ribosomal; Dose-Response Relationship, Drug; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1994 |
Augmentation of 5-fluoro-2'-deoxyuridine cytotoxicity by 5-phenethyl-2'-deoxyuridine in human gastric cancer cells in culture.
Topics: Carbon Radioisotopes; Deoxyuridine; DNA, Neoplasm; Drug Synergism; Floxuridine; Humans; Nucleosides; Nucleotides; RNA, Neoplasm; Stomach Neoplasms; Thymidine; Tritium; Tumor Cells, Cultured; Uridine | 1994 |
Enzyme aided regio-selective acylation and deacylation of nucleosides.
Topics: Acylation; Catalysis; Floxuridine; Hydrolysis; Lipase; Nucleosides; Uridine | 1993 |
Substrate selectivity, potential sensitivity and stoichiometry of Na(+)-nucleoside transport in brush border membrane vesicles from human kidney.
Topics: 2-Chloroadenosine; Adult; Aged; Biological Transport; Carrier Proteins; Dose-Response Relationship, Drug; Female; Floxuridine; Humans; Idoxuridine; Kidney; Male; Microvilli; Middle Aged; Nucleosides; Sensitivity and Specificity; Sodium; Substrate Specificity; Symporters; Thymidine; Uridine | 1993 |
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Liver; Mice; Placenta; Species Specificity; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 1993 |
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Interferon-gamma; Interleukin-1; Mice; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uridine; Uridine Phosphorylase | 1993 |
Synthesis and properties of 5-fluorouracil oligonucleotides.
Topics: Antimetabolites, Antineoplastic; Floxuridine; Molecular Structure; Oligonucleotides; Uridine | 1995 |
Irreversible cytotoxic effect of a novel lowly immunosuppressive antitumor fluorouridine derivative, UK-21.
Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; Flow Cytometry; Floxuridine; Fluorouracil; Glycine; Humans; Immunosuppressive Agents; KB Cells; Neoplastic Stem Cells; Thymidine; Uridine | 1997 |
Mechanisms for 5-fluorouracil resistance in human colon cancer DLD-1 cells.
Topics: Antimetabolites, Antineoplastic; Cell Count; Colorectal Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Intracellular Fluid; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1998 |
Effect of coadministered uridine on intestinal first-pass metabolism of 5'-deoxy-5-fluorouridine in conscious rats--an evaluation by method of portal-systemic concentration difference.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arteries; Drug Interactions; Floxuridine; Fluorouracil; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Portal System; Portal Vein; Rats; Rats, Wistar; Uridine | 1998 |
Bone morphogenetic protein-2, but not bone morphogenetic protein-7, promotes dendritic growth and calbindin phenotype in cultured rat striatal neurons.
Topics: Animals; Antimetabolites, Antineoplastic; Astrocytes; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Calbindins; Cell Count; Cell Differentiation; Cell Division; Cell Size; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Dendrites; Dose-Response Relationship, Drug; Drug Administration Schedule; Fetus; Floxuridine; gamma-Aminobutyric Acid; Immunohistochemistry; Neostriatum; Phenotype; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Transforming Growth Factor beta; Uridine | 2001 |
Acquisition of human concentrative nucleoside transporter 2 (hcnt2) activity by gene transfer confers sensitivity to fluoropyrimidine nucleosides in drug-resistant leukemia cells.
Topics: Biological Transport; Cell Division; DNA, Complementary; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Equilibrative Nucleoside Transporter 1; Floxuridine; Gene Transfer Techniques; Halogens; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Molecular Sequence Data; Purine Nucleosides; Pyrimidine Nucleosides; RNA, Messenger; Sodium; Structure-Activity Relationship; Tumor Cells, Cultured; Uridine | 2001 |
EFFECTS OF 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) AND 5-FLUOROURACIL (NSC-19893) ON CHILDHOOD LEUKEMIA.
Topics: Bone Marrow Examination; Child; Floxuridine; Fluorouracil; Leukemia; Leukopenia; Melena; Nausea; Toxicology; Uridine; Vomiting | 1964 |
THE CRYSTAL AND MOLECULAR STRUCTURE OF 5-FLURO-2'-DEOXY-BETA-URIDINE.
Topics: Chemical Phenomena; Chemistry; Floxuridine; Molecular Structure; Nucleic Acids; Research; Uridine | 1964 |
THE EFFECT OF 5-FLUORO-2'-DEOXYURIDINE ON SYNCHRONOUS MITOSIS IN PHYSARUM POLYCEPHALUM.
Topics: Cell Division; Deoxyuridine; DNA; Floxuridine; Metabolism; Mitosis; Pharmacology; Physarum polycephalum; Plasmodium; Research; RNA; Thymidine; Uridine | 1964 |
PROPERTIES OF DEOXYTHYMIDINE KINASE PARTIALLY PURIFIED FROM NONINFECTED MOUSE FIBROBLAST CELLS.
Topics: Animals; Bromodeoxyuridine; Cell Division; Deoxyuridine; Enzyme Inhibitors; Fibroblasts; Floxuridine; Immune Sera; Kinetics; Mice; Nucleotides; Phosphotransferases; Rabbits; Research; Simplexvirus; Thymidine; Thymidine Kinase; Tritium; Uridine; Vaccinia virus | 1965 |
ACUTE EFFECTS OF CYTOTOXIC COMPOUNDS ON INCORPORATION OF PRECURSORS INTO DNA, RNA, AND PROTEIN OF HELA MONOLAYERS.
Topics: Anti-Bacterial Agents; Antimetabolites; Dactinomycin; DNA; Floxuridine; HeLa Cells; Humans; Leucine; Mercaptopurine; Metabolism; Methotrexate; Nucleosides; Pharmacology; Proteins; Puromycin; Research; RNA; Streptonigrin; Thymidine; Tissue Culture Techniques; Triethylenemelamine; Urethane; Uridine; Vinblastine | 1965 |
EFFECT OF 5-FLUORO-2'-DEOXYURIDINE ON THE SYNTHESIS OF VACCINIA VIRUS.
Topics: Antigens; Autoradiography; Deoxyuridine; DNA; DNA, Viral; Floxuridine; Fluorescent Antibody Technique; HeLa Cells; Humans; Nucleosides; Nucleotides; Pharmacology; Research; Tissue Culture Techniques; Uridine; Vaccinia virus; Virus Cultivation | 1965 |
Effects of 5-fluorodeoxyuridine and related halogenated pyrimidines on the sand-dollar embryo.
Topics: Cytidine; DNA; Female; Floxuridine; Fluorouracil; Humans; Orotic Acid; Pregnancy; Pyrimidines; Thymidine; Thymine; Uridine | 1960 |
Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line.
Topics: Adenosine; Biological Transport; Caffeine; Dose-Response Relationship, Drug; Floxuridine; Humans; Membrane Transport Proteins; Molecular Sequence Data; Nicotine; Transfection; Tritium; Tumor Cells, Cultured; Uridine | 2004 |
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Irinotecan; Nucleic Acids; Organoplatinum Compounds; Oxaliplatin; Uridine | 2004 |
Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Cytochromes c; Enzyme Inhibitors; fas Receptor; Floxuridine; Genes, p53; Glucose; Glutathione; HL-60 Cells; Humans; Leukemia; Mitochondria; Reactive Oxygen Species; Thymidine; Thymidylate Synthase; U937 Cells; Uridine | 2004 |
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Floxuridine; Humans; Kinetics; Pyrimidines; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 2007 |
In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas.
Topics: Animals; Arabinofuranosyluracil; Blood-Brain Barrier; Brain; Brain Neoplasms; Floxuridine; Gene Expression; Glioma; Herpesvirus 1, Human; Iodine Radioisotopes; Male; Mice; Mice, Nude; Thymidine Kinase; Tissue Distribution; Uridine | 2008 |
Cytidine and deoxycytidylate deaminase inhibition by uridine analogs.
Topics: 3-Deazauridine; Azauridine; Bromodeoxyuridine; Cytidine Deaminase; DCMP Deaminase; Floxuridine; Humans; Kinetics; Uridine | 1980 |
Glycal formation in crystals of uridine phosphorylase.
Topics: Catalytic Domain; Cloning, Molecular; Crystallization; Escherichia coli; Floxuridine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Protein Conformation; Recombinant Proteins; Sulfates; Ultracentrifugation; Uridine; Uridine Phosphorylase | 2010 |
Bifunctional conjugates comprising β-cyclodextrin, polyethylenimine, and 5-fluoro-2'- deoxyuridine for drug delivery and gene transfer.
Topics: Animals; Antineoplastic Agents; Apoptosis; beta-Cyclodextrins; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA; Drug Carriers; Female; Floxuridine; Mice; Molecular Weight; Neoplasm Metastasis; Polyethyleneimine; Transfection; Uridine; Wound Healing | 2010 |
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Topics: Animals; Cell Cycle; Cell Line, Tumor; DNA; DNA Damage; DNA Repair; Endodeoxyribonucleases; Floxuridine; Fluorouracil; Gene Knockdown Techniques; Humans; Mice; MutS Homolog 2 Protein; RNA; Thymidine; Thymine DNA Glycosylase; Uracil-DNA Glycosidase; Uridine | 2011 |
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Topics: Administration, Oral; Algorithms; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Floxuridine; Fluorouracil; Indicators and Reagents; Mass Spectrometry; Tandem Mass Spectrometry; Uridine | 2013 |
An efficient method for dorsal root ganglia neurons purification with a one-time anti-mitotic reagent treatment.
Topics: Animals; Cell Survival; Cells, Cultured; Female; Floxuridine; Ganglia, Spinal; Immunohistochemistry; Myelin Sheath; Neurites; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Uridine | 2013 |
An Organic Afterglow Protheranostic Nanoassembly.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dimerization; Drug Delivery Systems; Floxuridine; Hydrogen Peroxide; Infrared Rays; Luminescent Agents; Mice; Nanoparticles; Neoplasms; Polyethylene Glycols; Prodrugs; Theranostic Nanomedicine; Tissue Distribution; Tumor Microenvironment; Uridine | 2019 |
Fluorinated pyrimidines. VI. Effects of 5-fluorouridine and 5-fluoro-2'-deoxyuridine on transplanted tumors.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; Neoplasms, Experimental; Pyrimidines; Uridine | 1958 |
Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.
Topics: Antineoplastic Agents; Deoxyuridine; Fluorouracil; Humans; Nucleosides; Nucleotides; Uridine | 1958 |