uric acid has been researched along with topiroxostat in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (65.52) | 24.3611 |
| 2020's | 10 (34.48) | 2.80 |
| Authors | Studies |
|---|---|
| Fujimori, S; Hara, S; Hisatome, I; Hosoya, T; Nomura, S; Ohno, I; Uchida, S; Yamamoto, T | 1 |
| Ohya, M; Shigematsu, T | 1 |
| Ashizawa, N; Iwanaga, T; Matsumoto, K; Saitoh, K; Taniguchi, T | 1 |
| Hashimoto, H; Hosoya, T; Ohashi, T; Sakamoto, R; Sasaki, T | 1 |
| Hashimoto, H; Hosoya, T; Ogawa, Y; Ohashi, T; Sakamoto, R | 1 |
| Ando, M; Kato, S; Katsuno, T; Kosugi, T; Maruyama, S; Mizukoshi, T; Nagata, T; Tsuboi, N | 1 |
| Hosoya, T; Ohashi, T; Sasaki, T | 1 |
| Abe, K; Kanno, S; Obata, K; Sekino, H; Sezai, A | 1 |
| Hatakeyama, Y; Horino, T; Ichii, O; Inoue, K; Matsumoto, T; Okuhara, Y; Shimamura, Y; Terada, Y | 1 |
| Fujigaki, Y; Hosoyamada, M; Kawamorita, Y; Kumagai, T; Nakagawa, T; Shibata, S; Shiraishi, T; Tamura, Y; Uchida, S | 1 |
| Mitsuboshi, S; Nagai, K; Okajima, H; Yamada, H | 1 |
| Akiyama, M; Iwai, S; Kanda, E; Kanno, Y; Miyaoka, Y; Nagai, M; Nagaoka, M; Nagaoka, Y; Ryu, K; Suzuki, R; Tanaka, Y; Ueda, M; Yoshimoto, H | 1 |
| Honda, D; Hosoya, T; Kimura, K; Narita, K; Okui, D; Sakamoto, R; Sasaki, T; Wada, T | 1 |
| Chang, WX; Kumagai, T; Shibata, S; Tamura, Y; Uchida, S | 1 |
| Hosoya, T; Ishikawa, T; Ogawa, Y; Ohashi, T; Sakamoto, R | 1 |
| Tohyo, S | 1 |
| DiPette, DJ; Ridley, E; Skeete, J | 1 |
| Fujimoto, Y; Higa, S; Kario, K; Shima, D; Tomitani, N | 1 |
| Meng, FH; Tu, S; Wu, YH; Zhang, TJ; Zhang, Y; Zhang, ZH | 1 |
| Fushimi, M; Ohashi, T; Okui, D; Sasaki, T | 1 |
| Osaka, S; Sekino, H; Sezai, A; Tanaka, M; Taoka, M; Unosawa, S | 1 |
| Hashimoto, T; Ichikawa, K; Ishikawa, T; Kanno, Y; Maeda, T; Nakagawa, T; Sato, Y | 1 |
| Sakaguchi, S | 1 |
| Amezawa, N; Arakawa, H; Kawakatsu, Y; Tamai, I | 1 |
| Abe, Y; Fukumoto, Y; Hisatome, I; Hongou, M; Hoshide, S; Kario, K; Kasai, T; Kiuchi, M; Kiyosue, A; Kuga, H; Kuramochi, J; Miyazaki, S; Nishizawa, M; Ohtani, H; Tomita, F; Yasu, T | 1 |
| Asai, K; Koen, M; Kubota, Y; Shimizu, W; Wakita, M | 1 |
| Akari, S; Katoh, N; Mizukami, H; Murase, T; Nakamura, T; Nampei, M; Satoh, E | 1 |
| Lee, YH; Song, GG | 1 |
| Iguchi, T; Ishiguro, C; Kajiyama, K; Kimura, R; Nakazato, Y; Oniyama, Y; Sawada, S; Shida, H; Uyama, Y | 1 |
2 review(s) available for uric acid and topiroxostat
| Article | Year |
|---|---|
Time to Target Uric Acid to Retard Chronic Kidney Disease Progression.
Topics: Allopurinol; Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily G, Member 2; Disease Progression; Enzyme Inhibitors; Febuxostat; Glucosides; Gout Suppressants; Humans; Hyperuricemia; Monosaccharide Transport Proteins; Nitriles; Oxidative Stress; Pyridines; Renal Insufficiency, Chronic; Risk Factors; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Uric Acid; Xanthine Oxidase | 2018 |
Comparative efficacy and safety of topiroxostat at different dosages in hyperuricemic patients with or without gout: A network meta-analysis of randomized controlled trials.
Topics: Gout; Gout Suppressants; Humans; Network Meta-Analysis; Nitriles; Pyridines; Randomized Controlled Trials as Topic; Treatment Outcome; Uric Acid | 2022 |
11 trial(s) available for uric acid and topiroxostat
| Article | Year |
|---|---|
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout.
Topics: Adiponectin; Aged; Albuminuria; Blood Pressure; Comorbidity; Creatinine; Double-Blind Method; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Gout; Humans; Hyperuricemia; Male; Middle Aged; Nitriles; Prevalence; Pyridines; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2014 |
Clinical efficacy and safety of topiroxostat in Japanese male hyperuricemic patients with or without gout: an exploratory, phase 2a, multicentre, randomized, double-blind, placebo-controlled study.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2016 |
Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout: a phase 3, multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study.
Topics: Adult; Aged; Allopurinol; Double-Blind Method; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2016 |
Randomized control trial for the assessment of the anti-albuminuric effects of topiroxostat in hyperuricemic patients with diabetic nephropathy (the ETUDE study).
Topics: Diabetic Nephropathies; Glomerular Filtration Rate; Humans; Hyperuricemia; Nitriles; Pyridines; Treatment Outcome; Uric Acid | 2016 |
Clinical efficacy and safety of topiroxostat in Japanese hyperuricemic patients with or without gout: a randomized, double-blinded, controlled phase 2b study.
Topics: Adult; Allopurinol; Double-Blind Method; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid; Young Adult | 2017 |
Cross-Over Trial of Febuxostat and Topiroxostat for Hyperuricemia With Cardiovascular Disease (TROFEO Trial).
Topics: Adult; Aged; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Diseases; Cross-Over Studies; Febuxostat; Female; Humans; Hyperuricemia; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid | 2017 |
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study).
Topics: Aged; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Male; Middle Aged; Nitriles; Pilot Projects; Pyridines; Treatment Outcome; Uric Acid; Xanthine Dehydrogenase | 2018 |
Multicenter, Open-Label Study of Long-Term Topiroxostat (FYX-051) Administration in Japanese Hyperuricemic Patients with or Without Gout.
Topics: Administration, Oral; Adult; Aged; Drug Administration Schedule; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid | 2018 |
The effect for hyperuricemia inpatient of uric acid overproduction type or in combination with topiroxostat on the pharmacokinetics, pharmacodynamics and safety of dotinurad, a selective urate reabsorption inhibitor.
Topics: Adult; Aged; Benzothiazoles; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Hyperuricemia; Inpatients; Middle Aged; Nitriles; Pyridines; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2020 |
Changeover Trial of Febuxostat and Topiroxostat for Hyperuricemia with Cardiovascular Disease: Sub-Analysis for Chronic Kidney Disease (TROFEO CKD Trial).
Topics: Aged; Antioxidants; Biomarkers; Cross-Over Studies; Down-Regulation; Enzyme Inhibitors; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Nitriles; Pyridines; Renal Insufficiency, Chronic; Time Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2020 |
Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia.
Topics: Febuxostat; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Nitriles; Pyridines; Treatment Outcome; Uric Acid | 2021 |
16 other study(ies) available for uric acid and topiroxostat
| Article | Year |
|---|---|
A new xanthine oxidase inhibitor: the uric acid reduction and additional efficacy in CKD patients.
Topics: Enzyme Inhibitors; Febuxostat; Humans; Hyperuricemia; Nitriles; Pyridines; Renal Insufficiency, Chronic; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2014 |
Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Inosine; Male; Nitriles; Oxonic Acid; Probenecid; Pyridines; Rats; Rats, Wistar; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Dehydrogenase | 2016 |
Effects of topiroxostat in hyperuricemic patients with chronic kidney disease.
Topics: Aged; Biomarkers; Blood Pressure; Enzyme Inhibitors; Female; Humans; Hypertension; Hyperuricemia; Incidence; Japan; Kidney; Male; Middle Aged; Nitriles; Proteinuria; Pyridines; Renal Insufficiency, Chronic; Retrospective Studies; Time Factors; Treatment Outcome; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2018 |
Renoprotective effect of topiroxostat via antioxidant activity in puromycin aminonucleoside nephrosis rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Cell Line; Deoxyguanosine; Enzyme Inhibitors; Kidney; Male; Mice; NADPH Oxidase 4; Nephrosis; Nitriles; Oxidative Stress; Podocytes; Puromycin Aminonucleoside; Pyridines; Rats; Rats, Sprague-Dawley; Uric Acid | 2017 |
Comparison of Clinical Advantage between Topiroxostat and Febuxostat in Hemodialysis Patients.
Topics: Adult; Aged; Febuxostat; Female; Follow-Up Studies; Humans; Hyperuricemia; Male; Middle Aged; Nitriles; Prospective Studies; Pyridines; Renal Dialysis; Uric Acid; Uricosuric Agents | 2017 |
The effect of small dose of topiroxostat on serum uric acid in patients receiving hemodialysis.
Topics: Aged; Enzyme Inhibitors; Female; Humans; Hyperuricemia; Male; Middle Aged; Nitriles; Pyridines; Renal Dialysis; Treatment Outcome; Uric Acid | 2018 |
Topiroxostat influences circulating lipid concentrations in hyperuricemic patients
.
Topics: Cholesterol; Cholesterol, LDL; Humans; Hyperuricemia; Lipids; Nitriles; Pyridines; Retrospective Studies; Treatment Outcome; Uric Acid | 2019 |
Could uric acid reduction by specific xanthine oxidase inhibition improve vascular function and reduce cardiovascular risk?
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Nitriles; Pyridines; Risk Factors; Uric Acid; Xanthine Oxidase | 2019 |
The effects of topiroxostat on vascular function in patients with hyperuricemia.
Topics: Biological Availability; Blood Flow Velocity; Enzyme Inhibitors; Female; Humans; Hyperuricemia; Male; Middle Aged; Nitriles; Pyridines; Reproducibility of Results; Retrospective Studies; Ultrasonography, Doppler; Uric Acid; Vasodilation; Xanthine Dehydrogenase | 2019 |
Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors.
Topics: Animals; Benzamides; Cattle; Drug Design; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Niacinamide; Nitriles; Protein Binding; Pyridines; Structure-Activity Relationship; Tetrazoles; Uric Acid; Xanthine Oxidase | 2019 |
Long-Term Safety and Effectiveness of the Xanthine Oxidoreductase Inhibitor, Topiroxostat in Japanese Hyperuricemic Patients with or Without Gout: A 54-week Open-label, Multicenter, Post-marketing Observational Study.
Topics: Adult; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Incidence; Japan; Male; Middle Aged; Nitriles; Product Surveillance, Postmarketing; Pyridines; Treatment Outcome; Uric Acid; Xanthine Dehydrogenase | 2020 |
Repair of Bone Erosion With Effective Urate-Lowering Therapy in a Patient With Tophaceous Gout.
Topics: Benzbromarone; Bone Resorption; Enzyme Inhibitors; Gout; Humans; Male; Metatarsal Bones; Metatarsophalangeal Joint; Middle Aged; Nitriles; Osteogenesis; Osteophyte; Pyridines; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2021 |
Renal Reabsorptive Transport of Uric Acid Precursor Xanthine by URAT1 and GLUT9.
Topics: Animals; Anion Transport Proteins; Benzothiazoles; Dogs; Glucose Transport Proteins, Facilitative; Kidney Tubules, Proximal; Madin Darby Canine Kidney Cells; Models, Animal; Monosaccharide Transport Proteins; Nitriles; Oocytes; Organic Anion Transporters; Organic Cation Transport Proteins; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Recombinant Proteins; Renal Elimination; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xenopus laevis | 2020 |
Effect of Topiroxostat on Brain Natriuretic Peptide Level in Patients with Heart Failure with Preserved Ejection Fraction: A Pilot Study.
Topics: Aged; Aged, 80 and over; Biomarkers; Gout; Heart Failure; Humans; Hyperuricemia; Middle Aged; Natriuretic Peptide, Brain; Nitriles; Pilot Projects; Pyridines; Stroke Volume; Treatment Outcome; Uric Acid | 2021 |
Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fatty Acids, Nonesterified; Humans; Hypoxanthine; Insulin; Liver; Male; Mice; Mice, Obese; Nitriles; Obesity; Pyridines; Triglycerides; Uric Acid; Weight Gain; Xanthine Dehydrogenase | 2021 |
Cardiovascular risk of urate-lowering drugs: A study using the National Database of Health Insurance Claims and Specific Health Checkups of Japan.
Topics: Allopurinol; Benzbromarone; Cardiovascular Diseases; Febuxostat; Gout; Gout Suppressants; Heart Disease Risk Factors; Humans; Insurance, Health; Japan; Risk Factors; Treatment Outcome; Uric Acid | 2023 |