uric acid has been researched along with probenecid in 391 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 288 (73.66) | 18.7374 |
| 1990's | 40 (10.23) | 18.2507 |
| 2000's | 23 (5.88) | 29.6817 |
| 2010's | 32 (8.18) | 24.3611 |
| 2020's | 8 (2.05) | 2.80 |
| Authors | Studies |
|---|---|
| Grassl, SM; Holtzman, EJ; Race, JE; Williams, WJ | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Endou, H; Hosoya, T; Hosoyamada, M; Ichida, K; Kimura, H; Takeda, M; Utsunomiya, Y | 1 |
| Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Cadenhead, A; Cameron, JS; Hatfield, PJ; Simmonds, HA | 1 |
| Beyer, KH; Bohn, DL; Fanelli, GM; Scriabine, A | 1 |
| Bohn, DL; Fanelli, GM; Zacchei, AG | 1 |
| Musil, J | 1 |
| Friedman, A; Steele, TH | 1 |
| Ryan, JR | 1 |
| Fanelli, GM; Weiner, IM | 4 |
| Boumendil-Podevin, EF; Podevin, RA; Priol, C | 1 |
| Boss, GR; Seegmiller, JE | 1 |
| Gancitano, A; Pallalardo, A | 1 |
| Fanelli, GM | 1 |
| Bassett, DR; Block, WD; Buckingham, RB; DiGaetano, R; Liou, LL; Mikkelsen, WM; Shakibai, A; Sidiq, M | 1 |
| Kleinschmidt, A; Schräpler, P; Schulz, E | 2 |
| Emmerson, BT | 1 |
| Bodison, W; Ellis, I; Fernandez, PC; Peitzman, SJ | 1 |
| Weiner, IM | 1 |
| Jain, AK; McMahon, FG; Ryan, JR | 2 |
| Beg, MA; Ragland, R | 1 |
| Bolli, P; Simpson, FO; Waal-Manning, HJ; Wood, AJ | 1 |
| Bentley, SK; Dantzler, WH | 1 |
| Diamond, HS; Holden, D; Meisel, AD | 1 |
| Simkin, PA | 2 |
| Gibson, T; Horner, I; Kilbourn, K; Simmonds, HA | 1 |
| Knight, TF; Sansom, S; Senekjian, HO; Weinman, EJ | 1 |
| Barrientos, A; Diaz-Gonzalez, R; Perez-Diaz, V; Rodicio, JL | 1 |
| Frank, M; Many, M; Sperling, O | 1 |
| de Vries, A; Sperling, O | 1 |
| Haese, E; Kleinschmidt, A; Schräpler, P | 1 |
| Benjamin, D; Pinkhas, J; Sperling, O; Weinberg, A | 1 |
| Abgarowicz, T; Brzozowska-Jurkowska, M; Eyman, E; Kawenoki-Minc, E; Weryńska-Przybylska, J | 1 |
| Benjamin, D; de Vries, A; Pinkhas, J; Sperling, O; Weinberger, A | 3 |
| Keller, C; Wolfram, G; Zöllner, N | 1 |
| Fannelli, GM; Weiner, IM | 1 |
| Roch-Ramel, F; Weiner, IM | 2 |
| Diamond, HS; Meisel, AD | 5 |
| Akaoka, I; Kamtani, N; Nishida, Y; Nishizawa, T; Sasaki, S; Yano, E | 1 |
| Frankfurt, SJ; Weinman, EJ | 1 |
| Brzozowska, AM; Eyman, E; Kawenoki-Minc, E; Weryńska-Przybylska, J | 1 |
| Berger, L; Dayton, PG; Israili, ZH; Perel, J; Roboz, J; Yü, TF | 1 |
| Lowenthal, DT | 1 |
| Yu, TF | 2 |
| Akaoka, I; Kawabe, K; Murayama, T | 1 |
| Arslan, Y; Diezi, J; Peters, G; Roch-Ramel, F | 1 |
| Kelley, WN | 2 |
| Schräpler, P; Schulz, E | 1 |
| Cacatian, A; Diamond, HS; Holden, D; Meisel, A; Sharon, E | 1 |
| Gottlieb, N; Grendelmeier, P; Rodriguez, E; Talbott, JH | 1 |
| Nicholson, G | 1 |
| Boer, P; de Vries, A; Sperling, O; Weinberger, A | 1 |
| Naess, K | 1 |
| Cloutier, MM; Guernsey, L | 1 |
| Jung, DK; Jung, JS; Kim, YK; Lee, SH | 1 |
| Iimura, O; Nakata, T | 1 |
| Hisatome, I; Ishimura, M; Kosaka, H; Kotake, H; Kouchi, T; Mitani, Y; Sasaki, N; Tanaka, Y; Yamakawa, M; Yoshida, A | 1 |
| Inagaki, H; Nakai, T; Shinosaki, T; Yamashita, T; Yonetani, Y | 1 |
| Kawachi, M; Kiyokawa, H; Kono, N; Kuwajima, M; Mineo, I; Nakajima, H; Shimizu, T; Tarui, S; Yorifuji, S | 1 |
| McCauley, FA; Walshaw, PE; Wilson, TW | 1 |
| Katinios, A; Magoula, I; Mavromatidis, K; Tsapas, G | 1 |
| Hisatome, I; Kobayashi, M; Kosaka, H; Kotake, H; Mashiba, H; Sasaki, N; Takeda, A; Tanaka, Y; Yamakawa, M; Yoshida, A | 1 |
| Kountouras, I; Kountouras, J; Magoula, I; Paletas, K; Tsapas, G | 1 |
| Barthelemy, CR; McCarthy, GM; Veum, JA; Wortmann, RL | 1 |
| Guisan, B; Roch-Ramel, F; Werner, D | 2 |
| Kawachi, M; Kiyokawa, H; Kono, N; Kuwajima, M; Mineo, I; Nakajima, H; Nishimura, T; Ono, A; Shimizu, T; Yorifuji, S | 1 |
| Shinosaki, T; Yonetani, Y | 2 |
| Magoula, I; Mavromatidis, K; Paletas, K; Tsapas, G | 1 |
| Hirata, Y; Itoh, H; Iwamoto, H; Marumo, F; Shichiri, M | 1 |
| Henderson, GB; Tsuji, JM | 1 |
| Hsieh, BS; Hsieh, YY; Lien, WP; Wu, TL | 1 |
| Rauer, S; Schollmeyer, P | 1 |
| Hada, T; Higashino, K; Suda, M; Takahashi, S; Yamamoto, T | 1 |
| MacDougall, ML; Wiegmann, TB | 1 |
| Goto, H; Ito, A; Mikami, T | 1 |
| Frydman, M; Gafter, U; Levi, J; Lewinski, UH; Zuta, A | 1 |
| Bontoux, D | 1 |
| Kahn, AM; Weinman, EJ | 1 |
| Colussi, G; De Ferrari, ME; Malberti, F; Minetti, L; Rolando, P; Rombolà, G; Surian, M | 1 |
| Cabo, J; Gomez-Ruiz, MD; Izquierdo, R; Rodilla, F; Sanchez-Beltran, MJ | 1 |
| Hada, T; Higashino, K; Moriwaki, Y; Takahashi, S; Yamamoto, T | 1 |
| Colussi, G; De Ferrari, ME; Minetti, L; Rombolà, G | 1 |
| Kateruttanakul, P; Sitprija, V; Tungsanga, K | 1 |
| Iwamoto, H; Kanayama, M; Maeda, M; Shichiri, M; Shiigai, T | 1 |
| German, DC; Holmes, EW | 1 |
| Kawenoki-Minc, E | 2 |
| Schoeman, HS; Sommers, DK | 1 |
| Garyfallos, A; Magoula, I; Tsapas, G | 1 |
| Arnalich, FF; Herrero, EH; Jimenez, ML; Mateos, FA; Puig, JG; Vazquez, JJ | 1 |
| Darlington, LG; Scott, JT | 1 |
| Conthe Gutiérrez, P; García Puig, J; López Jiménez, M; Mateos Antón, F | 1 |
| Iwamoto, H; Shichiri, M; Shiigai, T | 2 |
| Gomi, M; Iida, S; Kono, N; Moriwaki, K; Nakajima, H; Tarui, S | 1 |
| Shichiri, M; Shiigai, T | 1 |
| Donoso, VS; Grantham, JJ | 1 |
| Quebbemann, AJ; Tremaine, LM | 1 |
| Lo, B | 1 |
| Bird, JE; Quebbemann, AJ; Tremaine, LM | 1 |
| Atanes García, C; Ferrón Vidan, F; Larrañaga, JR; Mardomingo Varela, P; Pousa Estévez, L | 1 |
| Bar-Khayim, Y; Smetana, SS | 1 |
| Kahn, AM; Shelat, H; Weinman, EJ | 1 |
| Kanayama, M; Kijima, Y; Shichiri, M; Shiigai, T; Shinoda, T | 1 |
| Gougoux, A; Lemieux, G; Michaud, G; Vinay, P | 1 |
| Kippen, I; Klinenberg, JR; Whitehouse, MW | 1 |
| Elion, GB | 1 |
| Gutman, AB | 2 |
| Ball, GV; Freeman, D | 1 |
| McCarty, DJ | 1 |
| Gibson, T; Grahame, R | 1 |
| Rennick, BR | 1 |
| Cucinell, SA; Dayton, PG; Gutman, AB; Israili, ZH; Perel, JM; Tjandramaga, TB; Yü, TF | 1 |
| Danovitch, GM | 1 |
| Foulkes, EC; Johnson, DR | 1 |
| Auscher, C; de Gery, A; Delbarre, F; Saporta, L | 1 |
| Yü, T; Yu, TF | 1 |
| De Vries, A; Liberman, UA; Oliver, I; Sperling, O; Weinberger, A | 1 |
| Dent, CE; Stamp, TC | 1 |
| Blanchard, KC; Maroske, D; May, DG; Weiner, IM | 1 |
| Kawenoki-Minc, E; Zieliński, Z | 1 |
| Boner, G; Steele, TH | 1 |
| Diamond, HS; Paolino, JS | 1 |
| Borzelleca, JF; Putney, JW | 1 |
| Quebbemann, AJ | 1 |
| Grantham, JJ; Irwin, RL; Qualizza, PB; Tucker, DR; Whittier, FC | 1 |
| Bluestone, R; Campion, D; Klinenberg, JR; Whitehouse, M | 1 |
| Healey, LA; Simkin, PA; Skeith, MD | 1 |
| Holmes, EW; Kelley, WN | 1 |
| Diamond, HS; Sharon, E | 1 |
| Despopoulos, A; Jones, VD | 1 |
| Krasil'nikov, II | 1 |
| Kusus, T; Lydtin, H; Zöllner, N | 1 |
| Hvidberg, E | 1 |
| Goldfinger, SE | 1 |
| Gottesbüren, H; Strohmeyer, G | 1 |
| Kelley, WN; Wyngaarden, JB | 1 |
| Healey, LA; Skeith, MD | 1 |
| Dawson, D | 1 |
| Bohn, D; Fanelli, GM; Stafford, S | 1 |
| McMahon, FG | 1 |
| Bohn, DL; Fanelli, GM; Reilly, SS | 3 |
| Cunningham, RF; Dayton, PG; Goldstein, JH; Gutman, AB; Israili, ZH; Long, KR; Long, RC; Percel, JM; Yü, TF | 1 |
| Dörner, K; Harms, D; Manzke, H | 1 |
| Ina, K; Ito, M; Suzuki, Y; Yamagami, I | 1 |
| Moller, JV; Sheikh, MI | 1 |
| Boudry, JF | 1 |
| Nikolov, GS | 1 |
| Foulkes, EC; Nolan, RP | 1 |
| Gröbner, W; Zöllner, N | 1 |
| Freeman, RM; Shannon, IL | 2 |
| Duncan, GG; Duncan, TG; Schatanoff, J | 1 |
| Ewbank, RL; Kleinman, HZ | 1 |
| Hutchison, JC; McMahon, FG; Wilkinson, WH | 1 |
| Chauncey, HH; Shannon, IL | 1 |
| Klotz, H; Prohaska, E; Salmhofer, H; Schmid, L | 1 |
| Scott, JT | 1 |
| Bluestone, R; Kippen, I; Klinenberg, JR | 1 |
| Boudry, JF; Roch-Ramel, F | 1 |
| Bluestone, R; Kippen, I; Klinenberg, JR; Whitehouse, M | 1 |
| Bluestone, R; Kippen, I; Klinenberg, JR; Whitehouse, MW | 1 |
| Bluestone, R; Kippen, I; Klinenberg, JR; Whitehouse, WM | 1 |
| Gutman, AB; Kaung, C; Yü, TF | 1 |
| Eyman, E; Kawenoki-Minc, E; Sopata, I; Weryńska-Przybylska, J | 1 |
| Garcia, DA; Yendt, ER | 1 |
| Sabah, D | 1 |
| Dofel, W; Gröbner, W; Zöllner, N | 1 |
| Bluestone, R; Lewis, B; Mervart, I | 1 |
| Ban'kovskaia, EB; Klimov, AN; Sigareva, VM; Sil'vestrov, VP | 1 |
| Berndt, WO; McAlary, B; Mudge, GH | 1 |
| Elion, GB; Gutman, AB; Hitchings, GH; Yü, TF | 1 |
| Berndt, WO; Cucchi, J; Mudge, GH; O'Connell, JM; Platts, M | 1 |
| Riccitelli, ML | 1 |
| Highton, TC; Palmer, DG | 1 |
| Griendl, W; Kalb, R; Klein, G | 1 |
| Koch, G; Schlosser, GA | 1 |
| Killen, BU | 1 |
| Holländer, E; Schwarczmann, P | 1 |
| Berndt, WO | 2 |
| Thompson, GR | 1 |
| Bonardi, G; Coppi, G | 1 |
| Guidotti, FP; Lapidus, PW | 1 |
| Backmann, L; Bäumer, A | 1 |
| Moller, JV | 3 |
| Fishman, RA | 1 |
| Mikkelsen, WM; Strottman, MP; Thompson, GR | 1 |
| Brest, AN; Heider, C; Mehbod, H; Onesti, G | 1 |
| Freis, ED; Sappington, RF | 1 |
| Bartels, EC | 1 |
| Sjöberg, KH | 1 |
| Binder, E; Otto, W | 1 |
| Maclachlan, MJ; Rodnan, GP | 1 |
| Michener, WM | 1 |
| Jakovcic, S; Sorensen, LB | 1 |
| Beck, IT; Dossetor, JB; Oh, JH | 1 |
| Kaplan, NM | 1 |
| Simkin, PA; Wisner, DE | 1 |
| Paul, H; Reginato, A; Schumacher, HR | 1 |
| Branham, S; Kahn, AM; Weinman, EJ | 1 |
| Iwaki, K; Yonetani, Y | 2 |
| Geibel, J; Lang, F; Rehwald, W; Völkl, H | 1 |
| Higgens, CS; Scott, JT | 1 |
| Garcia Puig, J; Gaspar, G; Lesmes, A; Mateos Antón, F; Muñoz Sanz, A; Ortiz Vázquez, J; Ramos, T | 1 |
| Smorlesi, C; Zipser, RD | 1 |
| Gaspar, G; Gijón Baños, J; Mateos, F; Muñoz, A; Puig, JG; Ramos, T | 1 |
| Homma, Y; Kitamura, T; Nishimura, Y | 1 |
| Rodnan, GP | 1 |
| Møller, JV; Sheikh, MI | 1 |
| Deetjen, P; Dittrich, P; Greger, R; Griss, E; Lang, F; Lang, K; Oberleithner, H; Pastner, D | 1 |
| Arvidsson, A; Gillette, JR; Maling, HM; Saul, WF | 1 |
| Aronson, PS; Kahn, AM | 1 |
| Liberman, UA; Pinkhas, J; Schindel, B; Sperling, O; Weinberger, A | 1 |
| Abe, H; Fujiwara, Y; Orita, Y; Takamitsu, Y; Ueda, N | 1 |
| Schepers, GW | 1 |
| Cacini, W | 1 |
| Barbado, FJ; García Puig, J; Mateos, F; Muñoz Sanz, A | 1 |
| Aonuma, K; Ito, Y; Matsuda, O; Shiigai, T; Takeuchi, J | 1 |
| Kanayama, M; Matsuda, O; Shichiri, M; Shiigai, T; Takeuchi, J | 1 |
| Deutsch, E; Eilon, A; Zelig, S | 1 |
| Baiatova, KV | 1 |
| Garcia-Puig, J; Mateos, F; Muñez-Sanz, A | 1 |
| Hale, WE; Marks, RG; Stewart, RB; Yost, RL | 1 |
| Arnalich, F; Barbado, FJ; García Puig, J; Muñoz Sanz, A; Peña, JM; Redondo, C; Vázquez, JJ | 1 |
| Bollet, AJ | 1 |
| Day, RO | 1 |
| Borden, M; Kaufman, IA; Nyhan, WL; Stapleton, FB | 1 |
| Chonko, A; Edwards, R; Grantham, J; Shimomura, A; Tanner, R | 1 |
| Roch-Ramel, F; Schäli, C | 2 |
| Brooks, CD; Ulrich, JE | 1 |
| Babino, H; Knight, TF; Sansom, SC; Senekjian, HO; Steplock, DA; Weinman, EJ | 1 |
| Knight, TF; Sansom, SC; Senekjian, HO; Sheth, AU; Steplock, DA; Weinman, EJ | 1 |
| Chonko, AM | 1 |
| Shimada, H; Sugino, H | 1 |
| Estepa, MR; Gallego, N; Gámez, C; Marcén, R; Orofino, L; Ortuño, J; Sabater, J; Teruel, JL | 1 |
| Grenda, R; Januszewicz, P; Zawadzki, J | 1 |
| Hiroshige, K; Kuroiwa, A; Takasugi, M; Yuu, K | 1 |
| Kawai, S; Osawa, G; Yamada, M | 1 |
| Brouwer, KL; Fleishaker, JC; Golden, PL; Jewell, RC; Lyon, J; Millikin, S; Warner, PE | 1 |
| Jankowska, I; Januszewicz, P; Moszczyńska, A; Zawadzki, J | 1 |
| Fujimoto, Y; Hirata, N; Hisatome, I; Kosaka, H; Kotake, H; Mashiba, H; Sato, R; Shigemasa, C; Tanaka, Y; Yoshida, A | 1 |
| Brimioulle, S; Decaux, G; Prospert, F; Soupart, A | 1 |
| Emery, B; Hahn, B; Kaliner, MA; Ohkubo, K; Peden, DB; Swiersz, M | 1 |
| Castanheira, I; Neves, M; Patricio, L; Paulo, A; Sawas-Dimopoulou, C | 1 |
| Fujimoto, Y; Hisatome, I; Igawa, O; Kosaka, H; Manabe, I; Ohtahara, A; Ohtahara, K; Sawaguchi, M; Shigemasa, C; Takeda, A; Tanaka, Y; Tsuboi, M; Yoshida, A | 1 |
| Diezi, J; Guisan, B; Roch-Ramel, F | 1 |
| Eddy, MC; Leelawattana, R; McAlister, WH; Whyte, MP | 1 |
| Goriki, K; Ochiai, M; Okusaki, K; Takahashi, H; Toda, K; Tokunou, H; Uehara, S | 1 |
| Hirai, A; Saito, Y | 1 |
| Hamada, N; Hiroe, K; Hisatome, I; Kato, T; Kinugawa, T; Manabe, I; Ogino, K; Ohtahara, A; Sato, R; Shigemasa, C; Shimoyama, M; Takeda, A; Tanaka, Y; Tsuboi, M; Yamamoto, Y; Yoshida, A | 1 |
| Fend, F; Gruber, J; König, P; Lhotta, K; Sgonc, R | 1 |
| Decaux, G; Hannotier, P; Musch, W; Prospert, F; Soupart, A | 1 |
| Chazerain, P; Ziza, JM | 1 |
| Kuh, HJ; Shim, CK | 1 |
| Abe, T; Oda, Y; Watanabe, T | 1 |
| Alloway, J; Bryant, LR; Danaher, P; Harris, M | 1 |
| Gröbner, W; Walter-Sack, I | 1 |
| TALBOTT, JH | 1 |
| HOFFMAN, WS | 1 |
| MARSON, FG | 1 |
| LEVY, M; SAPIR, M; STROUN, J | 1 |
| GUTMAN, AB; RANDOLPH, V; YU, TF | 1 |
| GUTMAN, AB; YU, TF | 2 |
| POULSEN, H | 1 |
| CRONE, C; LASSEN, UV | 2 |
| HAYASHI, TT | 1 |
| EISENBERG, GM; FLIPPIN, HF; KAPLAN, A; WEISS, W | 1 |
| SIROTA, JH | 1 |
| CZACZKES, WJ; SADOWSKY, E; ULLMANN, TD | 1 |
| BERNSTEIN, A; BRONSKY, D; DUBIN, A | 1 |
| LACAPERE, J | 1 |
| CHRISTIANSEN, AH | 2 |
| HAAGENSEN, NR; NIELSEN, B | 1 |
| DUFF, IF; GALINDEZ, H; MIKKELSEN, WM; ROBINSON, WD; THOMPSON, GR | 1 |
| LAL, H; LAL, HB | 1 |
| HOLLANDER, E | 1 |
| ATTALI, P | 1 |
| BEISEL, WR; FORSHAM, PH; SMILO, RP | 1 |
| CASTLES, TR; WILLIAMSON, HE | 1 |
| KUSU, N; TAKAGI, Z | 1 |
| BAKER, OA; BEETHAM, WP; WILLIAMSON, CI | 1 |
| BYWATERS, EG; DIXON, AS; SCOTT, JT | 1 |
| MUDGE, GH; WEINER, IM | 1 |
| CRISTOFORI, FC; DUNCAN, GG | 1 |
| TREADWELL, B | 1 |
| REAH, TG | 1 |
| BLAU, RA; GIBBS, JO; GLOVER, RP; KUZELL, WC | 1 |
| HALL, AP; HOLLOWAY, VP; SCOTT, JT | 1 |
| EPSTEIN, FH; PIGEON, G | 1 |
| HAJDU, G; SIPOS, J | 1 |
| BEECHWOOD, EC; BERNDT, WO; MUDGE, GH | 1 |
| LECOCQ, FR; MCPHAUL, JJ | 1 |
| BEECHWOOD, EC; BERNDT, WO | 1 |
| RINGOIR, S | 1 |
| SMYTH, CJ; VELAYOS, EE | 1 |
| MCCORMICK, EW | 1 |
| BRONSKY, D; DUBIN, A; HOFFMAN, WS; PASCALE, LR | 1 |
| BISHOP, C; PFAFF, W | 1 |
| NECHAY, BR; NECHAY, L | 1 |
| LAVIETES, PH | 1 |
| Adachi, M; Endou, H; Hosoyamada, M; Itoh, K; Kitamura, K; Matsushita, K; Nonoguchi, H; Tanaka, M; Tomita, K; Wakita, N | 1 |
| BISHOP, C; RAND, R; TALBOTT, JH | 1 |
| BISHOP, C; LOCKIE, LM; NORCROSS, BM; TALBOTT, JH | 1 |
| GUTMAN, AB; SIROTA, JH; YU, TF | 1 |
| CHAMBERS, JS; PITTS, FW | 1 |
| Schackis, RC | 1 |
| Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Miyazaki, K; Shimamoto, S; Sugawara, M | 1 |
| Choy, G | 1 |
| Braun, EJ; Dudas, PL; Pelis, RM; Renfro, JL | 1 |
| Moreland, LW | 1 |
| Hosoyamada, M; Ichida, K; Shibasaki, T | 1 |
| Endou, H; Johnson, RJ; Long, DA; Miyazaki, H; Mu, W; Price, KL; Sautin, YY; Zhang, L | 1 |
| Belch, JJ; Carr, E; Davies, J; George, J; Struthers, A | 1 |
| Brouwers, JR; Houtman, PM; Jansen, TL; Reinders, MK; van Roon, EN | 1 |
| Cheng, CH; Fong, WP; Yu, Z | 1 |
| Austin, MD; Dibarnardi, AN; Hosick, PA; Hudson, MB; McAnulty, LS; McAnulty, SR; Milne, GL; Morrow, JD; Quindry, JC; Still, L | 1 |
| Day, RO; Graham, GG; McLachlan, AJ; Stocker, SL; Williams, KM | 2 |
| Brouwers, JR; Delsing, J; Griep, EN; Hoekstra, M; Jansen, TL; Reinders, MK; van de Laar, MA; van Roon, EN | 1 |
| Asch, SM; Hodges, JS; Singh, JA | 1 |
| Andrade, SE; Briesacher, BA; Fouayzi, H; Harrold, LR; Ockene, IS; Raebel, MA; Yood, RA | 1 |
| Schlesinger, N; Thiele, RG | 1 |
| Simon, HB | 1 |
| Junwei, Y; Lei, J; Li, F; Mingxia, X; Ping, W; Ruoyun, T; Weichun, H; Xiaohua, W; Yang, Z | 1 |
| Quillen, DM | 1 |
| Hisatome, I | 1 |
| Anzai, N; Endou, H; Enomoto, A; Fujimura, M; Miyazaki, H; Shin, HJ; Takeda, M | 1 |
| Kriegsmann, J; Lange, U; Müller-Ladner, U; Panzner, I; Tausche, AK | 1 |
| Adenwalla, HN; O'Connor, CR | 1 |
| Carey, JJ; Conway, R; Coughlan, RJ | 1 |
| Feig, DI; Soletsky, B | 1 |
| Dalbeth, N; Gow, PJ; Pui, K | 1 |
| Hsu, KC; Wang, FS | 1 |
| Bach, MH; Simkin, PA | 1 |
| Barbier, S; Han, R; Itahana, K; Itahana, Y; Lei, Z; Rozen, S | 1 |
| Bombardier, C; Buchbinder, R; Edwards, CJ; Kydd, AS; Seth, R | 2 |
| Dalbeth, N; Robinson, PC | 1 |
| Fitzgerald, KA; Gyongyosi, B; Iracheta-Vellve, A; Kodys, K; Kurt-Jones, EA; Petrasek, J; Saha, B; Satishchandran, A; Szabo, G | 1 |
| Ashizawa, N; Iwanaga, T; Matsumoto, K; Saitoh, K; Taniguchi, T | 1 |
| Bahn, A; Gold, E; Rodrigues, E; Sangkop, F; Singh, G | 1 |
| Stamp, LK | 1 |
| Borgi, L; Curhan, GC; Fisher, ND; Forman, JP; McMullan, C; Wohlhueter, A | 1 |
| Corbett, EJM; McGill, NW; Pentony, P | 1 |
| Borgi, L; Curhan, G; Fisher, N; Forman, J; McMullan, CJ | 1 |
| Abhishek, A | 1 |
| Case, R; Jester, G; Wentworth, B | 1 |
| Kang, DH | 1 |
| Guo, Z; Han, X; Li, D; Yang, J | 1 |
| Cheetham, TC; Levy, G; Rashid, N; Shi, JM | 1 |
| Robinson, PC | 1 |
| Chen-Xu, M; Choi, HK; Pillinger, MH; Rai, SK; Yokose, C | 1 |
| Cheung, PP; Chua, CKT; Lim, AYN; Santosa, A; Teng, GG | 1 |
| Dai, S; Guo, Y; Hong, F; Li, L; Liu, G; Pan, S; Qiao, X; Wang, J; Xie, X; Xu, P; Xue, T; Zhai, Y; Zheng, A | 1 |
| Aguayo-Guerrero, JA; Aguirre-Sierra, B; Bobadilla, K; Escobedo, G; López-Vidal, Y; Manjarrez-Reyna, AN; Martínez-Reyes, CP; Méndez-García, LA; Villalobos-Molina, R | 1 |
| Cao, Y; Chen, Y; Jiang, Y; Li, L; Li, Y; Pang, J; Wu, T; Zhao, Z; Zhou, P | 1 |
| Cheng, J; Gao, Y; He, F; Hisatome, I; Liu, W; Lu, J; Wang, Q; Wang, W; Yamamoto, T; Yu, W; Zhao, H | 1 |
| Chen, LR; Guo, Y; He, GH; Jiang, FF; Li, YJ; Qian, K; Wang, P; Yang, M; Yang, ZL; Yin, SJ | 1 |
| Chen, HC; Wei, JC; Yang, DH | 1 |
| Ashizawa, N; Chikamatsu, N; Iwanaga, T; Motoki, K; Sakai, M; Taniguchi, T; Yamano, K | 1 |
36 review(s) available for uric acid and probenecid
| Article | Year |
|---|---|
Hyperuricemia and gout. Classification, complications and management.
Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Indomethacin; Kidney; Kidney Calculi; Kidney Diseases; Lead Poisoning; Lymphoproliferative Disorders; Myeloproliferative Disorders; Phenylbutazone; Platelet Aggregation; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Uricosuric Agents | 1979 |
Urate excretion.
Topics: Acetohexamide; Animals; Benzbromarone; Benzofurans; Diuretics; Ethambutol; Halofenate; Humans; Mersalyl; Pan troglodytes; Probenecid; Salicylates; Sulfinpyrazone; Uric Acid; Zoxazolamine | 1977 |
[Gout. Diagnosis--pathogenesis--therapy].
Topics: Allopurinol; Balneology; Benzofurans; Crystallization; Diagnosis, Differential; Exercise Therapy; Glomerular Filtration Rate; Gout; Probenecid; Sulfinpyrazone; Uric Acid; Urinary Calculi | 1978 |
Drug control of gout and hyperuricaemia.
Topics: Allopurinol; Arthritis; Chronic Disease; Colchicine; Gout; Humans; Indomethacin; Naproxen; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1978 |
Urate transport in the nephron.
Topics: Animals; Biological Transport, Active; Glucose; Humans; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Mersalyl; p-Aminohippuric Acid; Permeability; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Pharmacologic approach to the maintenance of urate homeostasis.
Topics: Allopurinol; Diuresis; Gout; Homeostasis; Humans; Kidney Tubules; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1975 |
Urate transport in the proximal tubule: in vivo and vesicle studies.
Topics: Absorption; Animals; Basement Membrane; Bicarbonates; Biological Transport, Active; Chlorides; Dogs; Humans; Hydroxides; Hydroxyl Radical; Infant, Newborn; Isomerism; Kidney Tubules, Proximal; Lactates; Lactic Acid; Microvilli; Models, Biological; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Species Specificity; Uric Acid | 1985 |
Hyperuricemia and gout.
Topics: Acute Disease; Adult; Allopurinol; Anti-Inflammatory Agents; Arthritis; Arthrography; Calcinosis; Chronic Disease; Colchicine; Female; Gout; Humans; Kidney Calculi; Kidney Diseases; Middle Aged; Probenecid; Uric Acid | 1986 |
Pharmacology of uricosuric drugs.
Topics: Absorption; Animals; Anura; Biological Transport; Blood Proteins; Chemical Phenomena; Chemistry; Glomerular Filtration Rate; Haplorhini; Humans; Kidney Tubules; Pan troglodytes; Phenylbutazone; Probenecid; Protein Binding; Rats; Receptors, Drug; Salicylates; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1974 |
Crystal deposition joint disease.
Topics: Aged; Arthritis, Rheumatoid; Chondrocalcinosis; Colchicine; Crystallization; Diphosphates; Female; Gout; Humans; Indomethacin; Joint Diseases; Male; Phenylbutazone; Probenecid; Sulfinpyrazone; Synovial Fluid; Uric Acid; X-Ray Diffraction | 1974 |
Renal excretion of drugs: tubular transport and metabolism.
Topics: Aging; Aminohippuric Acids; Animals; Biogenic Amines; Biological Transport, Active; Catechols; Cell Membrane; Cholecystography; Creatinine; Diffusion; Dogs; Glomerular Filtration Rate; Humans; Hydroxyindoleacetic Acid; Ketoglutaric Acids; Kidney Concentrating Ability; Kidney Tubules; Methods; Osmolar Concentration; Pharmaceutical Preparations; Probenecid; Rabbits; Rats; Uric Acid | 1972 |
Uric acid transport in renal failure. A review.
Topics: Absorption; Biological Transport; Depression, Chemical; Homeostasis; Humans; Kidney; Kidney Failure, Chronic; Kidney Tubules; Nephrons; Probenecid; Protein Binding; Pyrazinamide; Uric Acid | 1972 |
Milestones in the treatment of gout.
Topics: Allopurinol; Colchicine; Gout; Humans; Indomethacin; Kidney Calculi; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1974 |
[On the therapeutic use of ethamide and benemid (probenecid)].
Topics: Catecholamines; Humans; Kidney; Probenecid; Uric Acid | 1968 |
[Drug therapy in gout].
Topics: Allopurinol; Chemical Phenomena; Chemistry; Colchicine; Gout; Humans; Phagocytosis; Probenecid; Purines; Uric Acid | 1971 |
Treatment of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Colchicine; Gout; Humans; Indomethacin; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase; Xanthines | 1971 |
[What is certain in gout therapy?].
Topics: Acute Disease; Allopurinol; Chronic Disease; Colchicine; Gout; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Kidney Tubules; Probenecid; Purines; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1971 |
Drug treatment of gout.
Topics: Acute Disease; Allopurinol; Arthritis; Colchicine; Gout; Humans; Orotic Acid; Probenecid; Structure-Activity Relationship; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1971 |
Treatment of the gout and other forms of crystal-induced arthritis.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzbromarone; Colchicine; Gout; Gout Suppressants; Humans; Indomethacin; Kidney; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1982 |
Renal organic anion transport system: pharmacological, physiological, and biochemical aspects.
Topics: Absorption; Animals; Anions; Anti-Bacterial Agents; Biological Transport; Diuretics; Humans; In Vitro Techniques; Kidney; Kidney Tubules; Ouabain; p-Aminohippuric Acid; Perfusion; Phenolsulfonphthalein; Phenylbutazone; Potassium; Probenecid; Sodium; Species Specificity; Substrate Specificity; Uric Acid | 1982 |
[Management of hyperuricemia in diabetes].
Topics: Allopurinol; Benzbromarone; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Humans; Insulin Resistance; Probenecid; Uric Acid; Uricosuric Agents | 1997 |
[DRUGS ACCELERATING EXCRETION OF URIC ACID].
Topics: Adrenocorticotropic Hormone; Androsterone; Blood Chemical Analysis; Body Fluids; Carbohydrates; Hexoses; Metabolism; Pharmacology; Phenylbutazone; Probenecid; Sweetening Agents; Uric Acid; Urine; Zoxazolamine | 1963 |
RENAL TUBULAR MECHANISMS FOR EXCRETION OF ORGANIC ACIDS AND BASES.
Topics: Acids; Biological Transport; Humans; Kidney; Kidney Tubules; p-Aminohippuric Acid; Pharmacology; Physiology; Probenecid; Uric Acid; Urine | 1964 |
An update on the treatment options for gout and calcium pyrophosphate deposition.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chondrocalcinosis; Colchicine; Drug Combinations; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Multicenter Studies as Topic; Probenecid; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2005 |
[Molecular mechanism in biological transport in the kidney: Urate transporter URAT1].
Topics: Animals; Benzbromarone; Carrier Proteins; Humans; Hyperuricemia; Kidney Tubules; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; RNA, Messenger; Transcription, Genetic; Uric Acid; Uricosuric Agents | 2006 |
Crystal arthropathies: recognizing and treating "the gouch".
Topics: Allopurinol; Antimetabolites; Chronic Disease; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thiazoles; Uric Acid; Uricosuric Agents | 2010 |
[Impact of serum uric acid level on the cardiovascular system as a risk factor].
Topics: Adipokines; Benzbromarone; Cardiovascular Diseases; Hyperuricemia; Kidney; Organic Anion Transporters; Organic Cation Transport Proteins; Oxidation-Reduction; Probenecid; Renal Tubular Transport, Inborn Errors; Risk Factors; Uric Acid; Uricosuric Agents; Urinary Calculi | 2010 |
[Gout - regardless of therapeutic options a "forgotten" disease].
Topics: Allopurinol; Arthritis, Gouty; Benzbromarone; Combined Modality Therapy; Cytokines; Europe; Febuxostat; Gout; Gout Suppressants; Guideline Adherence; Humans; Inflammasomes; Interleukin-1; Long-Term Care; Probenecid; Signal Transduction; Thiazoles; Uric Acid | 2011 |
Uricosuric drugs: the once and future therapy for hyperuricemia?
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Discovery; Enzyme Inhibitors; Glucose Transport Proteins, Facilitative; Gout; Humans; Hydrochlorothiazide; Hyperuricemia; Kidney Tubules, Proximal; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
Allopurinol for chronic gout.
Topics: Allopurinol; Benzbromarone; Chronic Disease; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Probenecid; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid | 2014 |
Uricosuric medications for chronic gout.
Topics: Adult; Aged; Allopurinol; Benzbromarone; Chronic Disease; Controlled Clinical Trials as Topic; Female; Gout; Humans; Male; Middle Aged; Probenecid; Randomized Controlled Trials as Topic; Uric Acid; Uricosuric Agents | 2014 |
Advances in pharmacotherapy for the treatment of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzbromarone; Clinical Trials, Phase III as Topic; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Probenecid; Thiazoles; Urate Oxidase; Uric Acid | 2015 |
Major unanswered questions in the clinical gout field.
Topics: Allopurinol; Benzbromarone; Colchicine; Disease Progression; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Patient Care Planning; Probenecid; Renal Insufficiency, Chronic; Uric Acid; Uricosuric Agents | 2017 |
New urate-lowing therapies.
Topics: Acetamides; Drug Interactions; Enzyme Inhibitors; Gout; Gout Suppressants; Humans; Phenylacetates; Probenecid; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Gout - An update of aetiology, genetics, co-morbidities and management.
Topics: Allopurinol; Chronic Disease; Comorbidity; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thioglycolates; Triazoles; Uric Acid | 2018 |
Comparative efficacy and safety of uricosuric agents in the treatment of gout or hyperuricemia: a systematic review and network meta-analysis.
Topics: Gout; Gout Suppressants; Humans; Hyperuricemia; Network Meta-Analysis; Probenecid; Randomized Controlled Trials as Topic; Uric Acid; Uricosuric Agents | 2023 |
33 trial(s) available for uric acid and probenecid
| Article | Year |
|---|---|
The metabolic spectrum of halofenate.
Topics: Blood Glucose; Cholesterol; Clinical Trials as Topic; Clofibrate; Creatine Kinase; Glycolates; Halofenate; Humans; Hyperlipidemias; Probenecid; Protein Binding; Thyroid Function Tests; Thyroxine; Tolbutamide; Triglycerides; Uric Acid | 1975 |
Effects of halofenate and probenecid on serum lipids and uric acid in hyperlipidemic, hyperuricemic adults.
Topics: Adult; Aged; Body Weight; Cholesterol; Clinical Trials as Topic; Female; Glycolates; Halofenate; Humans; Hyperlipidemias; Male; Middle Aged; Obesity; Probenecid; Triglycerides; Uric Acid | 1977 |
Ticrynafen and probenecid in hyperuricemic, hypertensive men.
Topics: Blood Pressure; Blood Urea Nitrogen; Clinical Trials as Topic; Creatinine; Diuresis; Double-Blind Method; Glycolates; Gout; Humans; Hypertension; Male; Middle Aged; Phenoxyacetates; Placebos; Probenecid; Thiophenes; Uric Acid; Uricosuric Agents | 1979 |
Comparison of ticrynafen and probenecid in patients with elevated uric acid levels.
Topics: Aged; Clinical Trials as Topic; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Probenecid; Uric Acid; Uricosuric Agents | 1979 |
Safety of tienilic acid.
Topics: Clinical Trials as Topic; Glycolates; Heart Failure; Humans; Hydrochlorothiazide; Hypertension; Kidney Diseases; Probenecid; Ticrynafen; Uric Acid | 1979 |
The hypouricaemic effect of tienilic acid: experience in patients with hyperuricaemia.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Double-Blind Method; Drug Administration Schedule; Female; Glycolates; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Probenecid; Ticrynafen; Uric Acid | 1979 |
Studies on tienilic acid in hypertensive hyperuricaemic patients in Dunedin, New Zealand.
Topics: Aged; Allopurinol; Clinical Trials as Topic; Cyclopenthiazide; Diuretics; Drug Therapy, Combination; Female; Glycolates; Humans; Hypertension; Kinetics; Male; Middle Aged; Probenecid; Sodium Chloride Symporter Inhibitors; Ticrynafen; Uric Acid | 1979 |
[The uricosuric effect of benzbromaron and probenecid under fasting conditions (author's transl)].
Topics: Benzbromarone; Benzofurans; Dose-Response Relationship, Drug; Fasting; Female; Humans; Kidney Tubules; Male; p-Aminohippuric Acid; Probenecid; Uric Acid | 1978 |
[The effect of benzbromarone on fasting-hyperuricemia as a model (author's transl)].
Topics: Adolescent; Adult; Benzbromarone; Benzofurans; Fasting; Female; Humans; Male; Middle Aged; Obesity; Probenecid; Purines; Uric Acid | 1978 |
[Treatment of hyperlipemia and hyperuricemia with 2-acetamidoethyl-(4-chlorophenyl)-(3-trifluoromethylphenoxy)-acetate (halofenate), a derivative of clofibrate].
Topics: Cholesterol; Clinical Trials as Topic; Female; Glycolates; Halofenate; Humans; Hyperlipidemias; Male; Probenecid; Triglycerides; Uric Acid | 1976 |
Diuretic and non-diuretic actions of furosemide: effects of probenecid.
Topics: Adult; Cyclooxygenase Inhibitors; Drug Interactions; Eicosanoids; Furosemide; Humans; Male; Natriuresis; Probenecid; Renin; Thromboxane B2; Uric Acid | 1992 |
Observations on the disposition of probenecid in patients receiving allopurinol.
Topics: Adult; Aged; Allopurinol; Animals; Blood Urea Nitrogen; Carbon Isotopes; Chromatography, Gas; Clinical Trials as Topic; Creatinine; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Liver; Male; Middle Aged; Probenecid; Proteins; Rats; Time Factors; Uric Acid; Xanthines | 1972 |
Treatment of gout and hyperuricaemia by benzbromarone, ethyl 2 (dibromo-3,5 hydroxy-4 benzoyl)-3 benzofuran.
Topics: Benzoates; Bromine; Clinical Trials as Topic; Creatinine; Gout; Humans; Hypoxanthines; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid; Xanthines | 1974 |
[Saluretic treatment of hypertension and uric acid level in serum. Clinical test of a combination of hydrochlorothiazide and probenecid].
Topics: Adult; Aged; Alanine Transaminase; Blood Glucose; Blood Pressure; Blood Protein Electrophoresis; Body Weight; Clinical Trials as Topic; Depression, Chemical; Diabetes Mellitus; Diuretics; Female; Hemoglobins; Humans; Hydrochlorothiazide; Hypertension; Leukocyte Count; Male; Middle Aged; Natriuresis; Placebos; Potassium; Probenecid; Sodium; Uric Acid; Urticaria | 1969 |
Uricosurics and xanthine oxidase inhibitors: a single-dose assay.
Topics: Adult; Allopurinol; Chlorothiazide; Humans; Male; Methods; Placebos; Probenecid; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1970 |
Refractory obesity and diabetes.
Topics: Adult; Body Weight; Diabetes Mellitus; Diet, Diabetic; Fasting; Female; Glucose Tolerance Test; Humans; Male; Middle Aged; Obesity; Phenformin; Placebos; Probenecid; Uric Acid | 1968 |
Comparison of allopurinol and probenecid.
Topics: Allopurinol; Clinical Trials as Topic; Colchicine; Enzyme Therapy; Follow-Up Studies; Gout; Humans; Liver Function Tests; Male; Probenecid; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Effect of drugs on urate binding to plasma proteins.
Topics: Adult; Allopurinol; Arthritis; Aspirin; Blood Proteins; Chromatography, DEAE-Cellulose; Colchicine; Female; Gout; Humans; Indomethacin; Male; Phenylbutazone; Probenecid; Protein Binding; Sulfinpyrazone; Uric Acid | 1969 |
Long-term effect of probenecid on diuretic-induced hyperuricemia.
Topics: Adult; Aged; Blood Chemical Analysis; Blood Pressure Determination; Body Weight; Chlorthalidone; Humans; Hydrochlorothiazide; Hypertension; Kidney Tubules; Male; Middle Aged; Potassium; Probenecid; Uric Acid | 1966 |
Renal handling of urate in healthy man in hyperuricaemia and renal insufficiency: circadian fluctuation, effect of water diuresis and of uricosuric agents.
Topics: Adult; Aged; Circadian Rhythm; Diuresis; Female; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Probenecid; Uric Acid; Uricosuric Agents; Water | 1980 |
Benzbromarone therapy in hyperuricaemia; comparison with allopurinol and probenecid.
Topics: Adult; Allopurinol; Benzbromarone; Benzofurans; Clinical Trials as Topic; Female; Humans; Male; Placebos; Probenecid; Uric Acid | 1981 |
Effects of probenecid on the pharmacokinetics and pharmacodynamics of adinazolam in humans.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Double-Blind Method; Drug Interactions; Drug Synergism; Humans; Kidney; Male; Memory, Short-Term; Probenecid; Psychomotor Performance; Uric Acid | 1994 |
Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Aspirin; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Middle Aged; Probenecid; Prospective Studies; Treatment Outcome; Uric Acid; Uricosuric Agents | 2000 |
Hyperuricaemia and preeclampsia: is there a pathogenic link?
Topics: Adult; Blood Pressure; Creatine; Female; Humans; Hyperuricemia; Platelet Count; Pre-Eclampsia; Pregnancy; Probenecid; Uric Acid | 2004 |
High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid.
Topics: Acetylcholine; Aged; Allopurinol; Ascorbic Acid; Blood Pressure; Cardiac Output, Low; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitroprusside; Oxidative Stress; Probenecid; Regional Blood Flow; Uric Acid; Uricosuric Agents; Vasodilator Agents | 2006 |
Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-treated gout patients.
Topics: Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Humans; Hyperuricemia; Male; Middle Aged; Probenecid; Uric Acid; Uricosuric Agents | 2007 |
Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects.
Topics: Adult; Allopurinol; Analysis of Variance; Area Under Curve; Chromatography, High Pressure Liquid; Creatinine; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Oxypurinol; Probenecid; Time Factors; Uric Acid | 2008 |
Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol.
Topics: Aged; Allopurinol; Benzbromarone; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Hypersensitivity; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Probenecid; Prospective Studies; Treatment Failure; Uric Acid | 2009 |
Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout.
Topics: Allopurinol; Drug Interactions; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Male; Middle Aged; Oxypurinol; Probenecid; Prospective Studies; Uric Acid; Uricosuric Agents | 2011 |
Uric acid reduction rectifies prehypertension in obese adolescents.
Topics: Adolescent; Allopurinol; Blood Pressure; Child; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Obesity; Prehypertension; Probenecid; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2012 |
Effect of Uric Acid-Lowering Agents on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Allopurinol; Brachial Artery; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Female; Follow-Up Studies; Gout Suppressants; Humans; Hypertension; Male; Overweight; Probenecid; Time Factors; Treatment Outcome; Ultrasonography, Doppler; Uric Acid; Uricosuric Agents; Vasodilation | 2017 |
Effect of Uric Acid Lowering on Renin-Angiotensin-System Activation and Ambulatory BP: A Randomized Controlled Trial.
Topics: Adult; Allopurinol; Angiotensin II; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Boston; Double-Blind Method; Down-Regulation; Female; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Probenecid; Renin; Renin-Angiotensin System; Time Factors; Treatment Outcome; Uric Acid; Uricosuric Agents; Young Adult | 2017 |
Early urate-lowering therapy in gouty arthritis with acute flares: a double-blind placebo controlled clinical trial.
Topics: Arthritis, Gouty; Chronic Disease; Colchicine; Gout; Gout Suppressants; Humans; Probenecid; Symptom Flare Up; Uric Acid | 2023 |
322 other study(ies) available for uric acid and probenecid
| Article | Year |
|---|---|
Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).
Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Biological Transport; Blotting, Northern; Carrier Proteins; Chromosomes, Human, Pair 11; Cloning, Molecular; Humans; Kidney; Mice; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Sequence Homology, Amino Acid; Xenopus laevis | 1999 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Urate transport via human PAH transporter hOAT1 and its gene structure.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Biological Transport; Blotting, Western; Carbon Radioisotopes; Cell Line; Cloning, Molecular; Exons; Female; Gene Library; Gout; Humans; Kidney; Kidney Diseases; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Protein Structure, Tertiary; Pyrazinamide; Sodium Salicylate; Uric Acid; Uricosuric Agents | 2003 |
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger | 2004 |
Uric acid excretion by the pig kidney.
Topics: Animals; Blood Proteins; Diuresis; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Kidney; Male; Probenecid; Pyrazinamide; Pyrazines; Swine; Uric Acid; Urine | 1976 |
Saluretic and uricosuric effects of (6, 7-dichloro-2-methyl=1-oxo-2-phenyl-5-indanyloxy) acetic acid (MK-196) in the chimpanzee.
Topics: Animals; Diuresis; Drug Interactions; Ethacrynic Acid; Furosemide; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Indans; Indenes; Male; Mersalyl; p-Aminohippuric Acid; Pan troglodytes; Potassium; Probenecid; Rats; Sodium Chloride; Stimulation, Chemical; Time Factors; Uric Acid; Uricosuric Agents | 1977 |
Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee.
Topics: Acetazolamide; Animals; Diuresis; Drug Interactions; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Indans; Indenes; Kidney; Male; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Pyrazines; Sodium Chloride; Time Factors; Uric Acid; Uricosuric Agents | 1977 |
Physiological characteristics of various experimental models for the study of disorders in purine metabolism.
Topics: Acidosis; Alkalosis; Allopurinol; Animals; Cholesterol; Disease Models, Animal; Diuresis; Fructose; Glycine; Gout; Hydrogen-Ion Concentration; Natriuresis; Oxonic Acid; Probenecid; Purines; Rats; Research Design; Species Specificity; Triazines; Triglycerides; Uric Acid | 1977 |
Supersaturation of urine with uric acid and urate: response to a uricosuric diuretic.
Topics: Crystallization; Diuretics; Female; Glycolates; Humans; Hydrogen-Ion Concentration; Male; Phenoxyacetates; Probenecid; Uric Acid; Urine | 1978 |
Urate excretion: drug interactions.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Glomerular Filtration Rate; Haplorhini; Male; Models, Biological; p-Aminohippuric Acid; Pan troglodytes; Probenecid; Pyrazinamide; Salicylates; Ultrafiltration; Uric Acid; Uricosuric Agents | 1979 |
Uric acid transport in brush border membrane vesicles isolated from rabbit kidney.
Topics: Animals; Biological Transport, Active; Bucladesine; Cell Membrane; Cyclic AMP; In Vitro Techniques; Kidney Tubules, Proximal; Microvilli; Ouabain; Probenecid; Rabbits; Sodium; Uric Acid | 1979 |
[Physiopathological bases for a rational therapy of gout].
Topics: Allopurinol; Benzofurans; Gout; Humans; Life Style; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1978 |
Effects of inhibitors in lumen on PAH and urate transport by isolated renal tubules.
Topics: Animals; Biological Transport, Active; Female; Hippurates; In Vitro Techniques; Kidney Tubules, Proximal; Male; Phenolsulfonphthalein; Probenecid; Snakes; Uric Acid | 1979 |
The natural history of urate overproduction in sickle cell anemia.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Creatinine; Female; Humans; Male; Middle Aged; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Management of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Colchicine; Female; Gout; Humans; Indomethacin; Patient Education as Topic; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1979 |
Mechanism and treatment of hypertriglyceridaemia in gout.
Topics: Alcohol Drinking; Allopurinol; Cholesterol; Gout; Humans; Hyperlipidemias; Male; Middle Aged; Obesity; Probenecid; Triglycerides; Uric Acid | 1979 |
Effects of intraluminal D-glucose and probenecid on urate absorption in the rat proximal tubule.
Topics: Absorption; Animals; Biological Transport, Active; Body Water; Glucose; Kidney Tubules, Proximal; Male; Perfusion; Phlorhizin; Probenecid; Rats; Uric Acid | 1979 |
Hypouricemia by defect in the tubular reabsorption.
Topics: Absorption; Adult; Female; Humans; Kidney Function Tests; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1979 |
Familial renal hypouricaemia: two additional cases with uric acid lithiasis.
Topics: Adult; Calcium; Humans; Jews; Kidney Calculi; Kidney Diseases; Male; Pedigree; Probenecid; Pyrazinamide; Recurrence; Uric Acid; Urinary Calculi | 1979 |
Inborn hypouricemia due to isolated renal tubular defect.
Topics: Adult; Calcium; Chromosome Aberrations; Chromosome Disorders; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1979 |
Familial hypouricemia due to isolated renal tubular abnormality.
Topics: Chromosome Aberrations; Chromosome Disorders; Genes, Recessive; Humans; Male; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1978 |
[Various aspects of nephropathy in gout].
Topics: Adult; Age Factors; Aged; Amyloidosis; Glomerular Filtration Rate; Gout; Humans; Hypertension, Renal; Kidney Diseases; Male; Middle Aged; Probenecid; Specific Gravity; Uric Acid; Urinary Calculi | 1978 |
Hereditary renal hypouricemia: heterogeneity of tubular abnormality.
Topics: Adult; Calcium; Female; Humans; Male; Middle Aged; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid | 1978 |
Renal urate excretion in animal models.
Topics: Allopurinol; Animals; Carboxylic Acids; Dogs; Goats; Haplorhini; Humans; Kidney; Kidney Tubules, Proximal; Male; Mersalyl; Pan troglodytes; Probenecid; Pyrazines; Uric Acid | 1975 |
Species variations among primates in responses to drugs which alter the renal excretion of uric acid.
Topics: Animals; Female; Haplorhini; Humans; Kidney; Male; Pan troglodytes; Probenecid; Protein Binding; Pyrazinamide; Salicylates; Species Specificity; Uric Acid; Uricosuric Agents | 1975 |
Inhibition of urate excretion by pyrazinoate: a micropuncture study.
Topics: Animals; Carbon Radioisotopes; Female; Haplorhini; Infusions, Parenteral; Inulin; Kidney Tubules; Male; Mannitol; Probenecid; Pyrazines; Uric Acid | 1975 |
Inhibition of probenecid uricosuria by pyrazinamide and para-aminohippurate.
Topics: Adolescent; Adult; Aminohippuric Acids; Depression, Chemical; Humans; Male; Middle Aged; p-Aminohippuric Acid; Probenecid; Pyrazinamide; RNA; Uric Acid | 1977 |
Familial hypouricemia due to isolated renal tubular defect. Attenuated response of uric acid clearance to probenecid and pyrazinamide.
Topics: Adult; Female; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules, Proximal; Probenecid; Pyrazinamide; Uric Acid | 1977 |
Renal tubular transport of urate in Fanconi syndrome.
Topics: Amino Acids; Biological Transport; Fanconi Syndrome; Female; Glomerular Filtration Rate; Glycosuria; Humans; Kidney Tubules; Middle Aged; Phosphates; Probenecid; Pyrazinamide; Uric Acid | 1977 |
Evidence for two secretory mechanisms for organic acid transport in man.
Topics: Biological Transport; Humans; Kidney Tubules; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1977 |
Classification of uricosuric states based upon response to pharmacologic inhibitors of urate transport.
Topics: Anemia, Sickle Cell; Aspirin; Biological Transport; Diatrizoate; Fanconi Syndrome; Glomerular Filtration Rate; Humans; Kidney Tubules; Probenecid; RNA; Saline Solution, Hypertonic; Sulfinpyrazone; Uric Acid; Water-Electrolyte Balance | 1977 |
Familial renal hypouricemia due to isolated tubular defect.
Topics: Adult; Female; Humans; Kidney Function Tests; Pedigree; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1977 |
Renal urate excretion in five cases of hypouricemia with an isolated renal defect of urate transport.
Topics: Adult; Humans; Male; Middle Aged; Pedigree; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1977 |
Effect of pharmacological inhibitors on urate transport during induced uricosuria.
Topics: Adult; Biological Transport; Humans; Kidney; Middle Aged; Probenecid; Pyrazinamide; RNA; Sodium Chloride; Uric Acid | 1977 |
The effect of probenecid on urate transport in the rat kidney.
Topics: Animals; Biological Transport; Glomerular Filtration Rate; Kidney; Male; Metabolic Clearance Rate; Probenecid; Rats; Uric Acid | 1977 |
[Comparison of effects of various therapeutic methods of the urinary system in patients with gout. Observations on 195 patients with gout].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Probenecid; Uric Acid; Urinary Tract | 1977 |
The effect of the interaction of pyrazinamide and probenecid on urinary uric acid excretion in man.
Topics: Adult; Aged; Drug Interactions; Half-Life; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1977 |
The treatment of hyperuricemia.
Topics: Allopurinol; Drug Interactions; Drug Therapy, Combination; Humans; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1976 |
Pharmacokinetic and clinical studies of a new uricosuric agent - benzbromarone.
Topics: Adult; Aged; Arthritis; Benzbromarone; Benzofurans; Chemical Phenomena; Chemistry; Chronic Disease; Gout; Humans; Hydrochlorothiazide; Kinetics; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid | 1976 |
A case of uric acid renal stone with hypouricemia caused by tubular reabsorptive defect of uric acid.
Topics: Creatinine; Glycine; Humans; Kidney Calculi; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1976 |
[Pharmacologic modifications of renal tubular transport].
Topics: Acetazolamide; Biological Transport; Cell Membrane Permeability; Diuretics; Furosemide; Humans; Kidney Tubules; Probenecid; Uric Acid | 1976 |
Current therapy of gout and hyperuricemia.
Topics: Allopurinol; Colchicine; Drug Interactions; Gout; Humans; Indomethacin; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1976 |
[Pathogenesis of hyperuricemia and its treatment by means of rigorous fasting (so-called null-diet)].
Topics: Allopurinol; Fasting; Humans; Obesity; Probenecid; Uric Acid | 1976 |
Hyperuricosuria and increased tubular secretion of urate in sickle cell anemia.
Topics: Adolescent; Adult; Aminohippuric Acids; Anemia, Sickle Cell; Biological Transport; Female; Glomerular Filtration Rate; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; RNA; Saccharomyces cerevisiae; Uric Acid | 1975 |
Gouty arthritis in the black race.
Topics: Adult; Aged; Anemia, Sickle Cell; Arthritis; Benzothiadiazines; Black People; Colchicine; Diuretics; Female; Gout; Humans; Hypertension; Kidney; Male; Melena; Menstruation; Middle Aged; Pregnancy; Probenecid; Sex Factors; Sodium Chloride Symporter Inhibitors; Uric Acid | 1975 |
Gout: diagnosis and management.
Topics: Allopurinol; Anti-Inflammatory Agents; Gout; Humans; Probenecid; Uric Acid | 1975 |
Transport into erythrocytes and intestinal absorption of uric acid in hereditary renal hypouricemia.
Topics: Biological Transport; Erythrocytes; Humans; Hypoxanthines; Intestinal Absorption; Phenotype; Probenecid; Renal Tubular Transport, Inborn Errors; Uric Acid | 1975 |
[Uricosuric agents: Should they be used in asymptomatic hyperuricemia?].
Topics: Allopurinol; Humans; Metabolic Diseases; Probenecid; Sulfinpyrazone; Uric Acid | 1976 |
p-Aminohippurate transport in airways: competitive inhibition.
Topics: Animals; Biological Transport; Cyclic AMP; Dogs; Electrophysiology; Epithelium; p-Aminohippuric Acid; Phenolsulfonphthalein; Probenecid; Trachea; Uric Acid | 1992 |
Urate excretion by the cat kidney.
Topics: Animals; Cats; Female; Kidney; Male; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1992 |
[The management of hyperuricemia associated with drug treatment of hypertension].
Topics: Acidosis; Adrenergic beta-Antagonists; Allopurinol; Antihypertensive Agents; Benzothiadiazines; Diuretics; Humans; Probenecid; Sodium Chloride Symporter Inhibitors; Sulfinpyrazone; Uric Acid | 1992 |
Renal handling of urate in two patients with hyperuricemia and primary hyperparathyroidism.
Topics: Aged; Female; Humans; Hyperparathyroidism; Kidney; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1992 |
Circadian rhythm of plasma uric acid and handling stress-induced hyperuricemia in conscious cebus monkeys.
Topics: Animals; Benzbromarone; Cebus; Circadian Rhythm; Diazepam; Female; Gum Arabic; Handling, Psychological; Male; Probenecid; Stress, Physiological; Uric Acid | 1992 |
Decreased renal clearance of xanthine and hypoxanthine in a patient with renal hypouricemia: a new defect in renal handling of purines.
Topics: Humans; Hypoxanthine; Hypoxanthines; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Parkinson Disease; Probenecid; Pyrazinamide; Uric Acid; Xanthine; Xanthines | 1992 |
Single kidney function: early and late changes in urate transport after nephrectomy.
Topics: Adult; Aged; Biological Transport, Active; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Tubules; Male; Middle Aged; Nephrectomy; Probenecid; Pyrazinamide; Renal Circulation; Time Factors; Uric Acid | 1992 |
Two cases of persistent hypouricemia associated with diabetes mellitus.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1992 |
Cholangiocarcinoma and severe renal hypouricemia: a study of the renal mechanisms.
Topics: Adenoma, Bile Duct; Bile Duct Neoplasms; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1991 |
Influence of antihyperuricemic therapy on the clinical and radiographic progression of gout.
Topics: Aged; Aged, 80 and over; Allopurinol; Arthritis, Gouty; Humans; Middle Aged; Probenecid; Radiography; Uric Acid; Wrist | 1991 |
Urate transport in the proximal tubule of human kidney.
Topics: Biological Transport; Humans; Kidney Cortex; Kidney Tubules, Proximal; Kinetics; Lactates; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Uric Acid | 1991 |
Renal hypouricemia associated with hyperoxypurinemia due to decreased renal excretion of oxypurines: a new defect in renal purine transport.
Topics: Diet; Humans; Hypoxanthine; Hypoxanthines; Kidney Diseases; Kidney Tubules; Kinetics; Male; Middle Aged; Probenecid; Purines; Pyrazinamide; Uric Acid; Xanthine; Xanthines | 1991 |
Hyperuricemia induced by the uricosuric drug probenecid in rats.
Topics: Allopurinol; Animals; Hepatectomy; Hypoxanthines; Inulin; Kidney Function Tests; Male; Oxonic Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Uric Acid; Xanthines | 1991 |
Insulin-dependent diabetes and renal hypouricemia.
Topics: Adolescent; Adult; Creatinine; Diabetes Mellitus, Type 1; Female; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1991 |
Renal tubular hypouricemia: evidence for defect of both secretion and reabsorption.
Topics: Aged; Aspirin; Creatinine; Furosemide; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1990 |
Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cholic Acids; Cytochalasin B; Folic Acid; Glucose; Leukemia L1210; Methotrexate; Mice; Probenecid; Substrate Specificity; Sulfobromophthalein; Temperature; Tumor Cells, Cultured; Uric Acid; Vincristine | 1990 |
Probenecid interferes with the natriuretic action of furosemide.
Topics: Adult; Aged; Diet, Sodium-Restricted; Drug Therapy, Combination; Female; Furosemide; Humans; Kinetics; Male; Middle Aged; Natriuresis; Probenecid; Uric Acid | 1987 |
Evaluation of urate renal handling in humans.
Topics: Adult; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Male; Probenecid; Pyrazinamide; Uric Acid | 1989 |
Effect of probenecid on oxypurines in plasma.
Topics: Adenosine Deaminase; Adult; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Male; Probenecid; Purine-Nucleoside Phosphorylase; Uric Acid; Xanthine Oxidase; Xanthines | 1989 |
Urate excretion by the isolated perfused rat kidney and modification by drugs.
Topics: Animals; Furosemide; Glomerular Filtration Rate; Kidney; Natriuresis; Oxonic Acid; Perfusion; Probenecid; Pyrazinamide; Rats; Salicylates; Salicylic Acid; Uric Acid | 1989 |
Stop-flow studies on tubular transport of uric acid in rats.
Topics: Animals; Kidney; Male; Metabolic Clearance Rate; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Stereoisomerism; Sulfonamides; Ticrynafen; Uric Acid | 1989 |
[Effect of exercise on urate excretion].
Topics: Adult; Benzbromarone; Depression, Chemical; Exercise; Glomerular Filtration Rate; Humans; Kidney; Male; Probenecid; Pyrazinamide; Uric Acid | 1989 |
Hypouricemia due to familial isolated renal tubular uricosuria. Evaluation with the combined pyrazinamide-probenecid test.
Topics: Creatinine; Female; Humans; Kidney; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1989 |
[Hypo-uricemia].
Topics: Allopurinol; Humans; Nucleotides; Probenecid; Urate Oxidase; Uric Acid | 1989 |
Pharmacological evaluation of urate renal handling in humans: pyrazinamide test vs combined pyrazinamide and probenecid administration.
Topics: Adult; Aged; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Premedication; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Inhibition of purine catabolism by benzbromarone in isolated rat liver cells. Comparison with allopurinol and probenecid.
Topics: Allopurinol; Animals; Benzbromarone; Benzofurans; In Vitro Techniques; Liver; Male; Probenecid; Purines; Rats; Rats, Inbred Strains; Uric Acid | 1988 |
Renal excretion of purine bases. Effects of probenecid, benzbromarone and pyrazinamide.
Topics: Adult; Benzbromarone; Benzofurans; Biological Transport, Active; Female; Humans; Hypoxanthine; Hypoxanthines; Kidney; Male; Probenecid; Purines; Pyrazinamide; Uric Acid; Xanthine; Xanthines | 1988 |
Hypouricemia due to increased tubular urate secretion.
Topics: Humans; Kidney Tubules; Probenecid; Pyrazinamide; Uric Acid | 1988 |
The renal handling of urate in acute renal failure patients with high urine uric acid/urine creatinine concentration ratio.
Topics: Acute Kidney Injury; Adult; Creatine; Female; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1988 |
Hypouricemia due to subtotal defect in the urate transport.
Topics: Adult; Biological Transport; Female; Humans; Kidney Diseases; Kidney Tubules; Probenecid; Pyrazinamide; Uric Acid | 1987 |
[Effect of decrease in hyperuricemia levels on joint, kidney and other symptoms in patients with gout].
Topics: Adult; Aged; Allopurinol; Arthritis; Colchicine; Coronary Disease; Gout; Humans; Hypertension; Middle Aged; Probenecid; Uric Acid; Urinary Calculi | 1987 |
Drug interactions with urate excretion in man.
Topics: Adult; Ampicillin; Benzbromarone; Benzofurans; Drug Interactions; Humans; Kidney; Kinetics; Male; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Evaluation of the renal mechanisms for urate homeostasis in uremic patients by probenecid and pyrazinamide test.
Topics: Absorption; Creatinine; Female; Glomerular Filtration Rate; Gout; Homeostasis; Humans; Kidney Failure, Chronic; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uremia; Uric Acid | 1987 |
Diminished tubular secretion of urate in gout not dependent on serum urate levels.
Topics: Adult; Aged; Gout; Humans; Kidney Tubules; Kinetics; Male; Middle Aged; Nephrons; Probenecid; Reference Values; Uric Acid | 1986 |
Study of the effect of hypouricaemic therapy on serum lipid levels in gout patients.
Topics: Allopurinol; Cholesterol; Cholesterol, HDL; Gout; Humans; Lipids; Probenecid; Triglycerides; Uric Acid | 1986 |
Renal handling of uric acid in gout: impaired tubular transport of urate not dependent on serum urate levels.
Topics: Adult; Aged; Biological Transport, Active; Gout; Humans; Kidney Tubules; Kinetics; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1986 |
Hypouricemia due to increased tubular urate secretion.
Topics: Creatinine; Female; Humans; Kidney Tubules; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Familial renal hypouricemia with intact reabsorption of uric acid.
Topics: Adult; Female; Humans; Kidney Diseases; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Diabetic renal hypouricemia.
Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1987 |
Hypouricemia in the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Humans; Inappropriate ADH Syndrome; Metabolic Clearance Rate; Probenecid; Uric Acid | 1986 |
Characteristics of renal p-aminohippurate and urate excretion in rabbits.
Topics: Aminohippuric Acids; Animals; Blood Proteins; Female; Kidney; Kinetics; p-Aminohippuric Acid; Probenecid; Protein Binding; Rabbits; Uric Acid | 1986 |
The renal handling of terephthalic acid.
Topics: Animals; Carbon Radioisotopes; Chickens; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Humans; In Vitro Techniques; Infusions, Parenteral; Kidney; Male; p-Aminohippuric Acid; Phthalic Acids; Probenecid; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Uric Acid | 1985 |
Hyperuricemia and gout.
Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis; Colchicine; Female; Gout; Humans; Indomethacin; Kidney Calculi; Male; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1985 |
Renal tubular excretory transport of oxalate in the chicken.
Topics: Animals; Biological Transport; Chickens; Dicarboxylic Acids; Kidney Tubules; Oxalates; p-Aminohippuric Acid; Phthalic Acids; Probenecid; Uric Acid | 1985 |
[Hypouricemia caused by an isolated tubular defect. Apropos of a case].
Topics: Humans; Male; Middle Aged; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1985 |
Hypouricemia due to renal tubular defect. A study with the probenecid-pyrazinamide test.
Topics: Adult; Calcium; Creatinine; Female; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1985 |
Urate and p-aminohippurate transport in rat renal basolateral vesicles.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport; Chlorides; Ion Exchange; Kidney; Lactates; Membranes; p-Aminohippuric Acid; Potassium; Probenecid; Rats; Rats, Inbred Strains; Sodium; Uric Acid | 1985 |
Renal handling of urate in the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Aged; Female; Humans; Inappropriate ADH Syndrome; Kidney; Male; Metabolic Clearance Rate; Middle Aged; Probenecid; Uric Acid | 1985 |
Excretion of urate by the kidneys of Cebus monkeys: a micropuncture study.
Topics: Animals; Diuresis; Female; Glomerular Filtration Rate; Haplorhini; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Loop of Henle; Male; Probenecid; Punctures; Uric Acid | 1973 |
Nature of the uricosuric action of benziodarone.
Topics: Adult; Aminohippuric Acids; Animals; Benzofurans; Carbon Isotopes; Creatinine; Female; Glomerular Filtration Rate; Haplorhini; Humans; Inulin; Iodobenzoates; Kidney Tubules; Kidney Tubules, Proximal; Male; Probenecid; Pyrazinamide; Tritium; Uric Acid; Uricosuric Agents | 1973 |
Drugs in the treatment of hyperuricemia.
Topics: Allopurinol; Gout; Humans; Oxypurinol; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1974 |
Recent developments in the therapy of gout.
Topics: Acute Disease; Adrenocorticotropic Hormone; Allopurinol; Analgesics; Colchicine; Gout; Humans; Oxyphenbutazone; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1968 |
Management of chronic and recurrent gout.
Topics: Adrenocorticotropic Hormone; Allopurinol; Chronic Disease; Colchicine; Dexamethasone; Diet Therapy; Gout; Humans; Indomethacin; Lidocaine; Phenylbutazone; Prednisolone; Probenecid; Recurrence; Synovial Fluid; Uric Acid | 1971 |
Gout and hyperlipidaemia.
Topics: Adult; Aged; Alcohol Drinking; Allopurinol; Aspartate Aminotransferases; Body Height; Body Weight; Cholesterol; Gout; Humans; Hyperlipidemias; Liver; Male; Middle Aged; Obesity; Probenecid; Sulfobromophthalein; Triglycerides; Uric Acid | 1974 |
Bidirectional renal urate transport in the chimpanzee. Effects of drugs on secretory and reabsorptive fluxes.
Topics: Aminohippuric Acids; Animals; Biological Transport; Glomerular Filtration Rate; Kidney Tubules; Kidney Tubules, Distal; Male; Mersalyl; Pan troglodytes; Probenecid; Pyrazinamide; Pyrazines; Salicylates; Uric Acid; Uricosuric Agents | 1974 |
Localization of urate and phosphate reabsorption in the mongrel dog kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Carbon Radioisotopes; Cell Membrane; Cyanides; Dogs; Indicator Dilution Techniques; Kidney Tubules; Phosphates; Phosphorus Radioisotopes; Probenecid; Uric Acid | 1973 |
Hypouricemia, hypercalciuria, and decreased bone density: a hereditary syndrome.
Topics: Aged; Bone Density; Bone Diseases; Calcium; Calcium Gluconate; Child; Child, Preschool; Consanguinity; Female; Humans; Male; Middle Aged; Pedigree; Probenecid; Pyrazinamide; Syndrome; Uric Acid | 1974 |
Treatment of calcinosis circumscripta with probenecid.
Topics: Adult; Calcinosis; Calcium; Edetic Acid; Female; Fingers; Humans; Joint Diseases; Phosphates; Probenecid; Radiography; Uric Acid | 1972 |
Uricosuric potency of 2-substituted analogs of probenecid.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Chlorine; Female; Haplorhini; Humans; Hydrogen-Ion Concentration; Hydroxylation; Kidney; Kinetics; Male; Nitro Compounds; Probenecid; Uric Acid; Uricosuric Agents | 1972 |
Effect of balneotherapy in Ciechocinek Spa on the occurrence of gouty attacks and the symptoms of chronic gouty arthropathy (observations of 112 cures).
Topics: Adult; Aged; Allopurinol; Balneology; Blood Sedimentation; Colchicine; Female; Gout; Humans; Male; Middle Aged; Probenecid; Uric Acid | 1972 |
Origins of the uricosuric response.
Topics: Adult; Aminohippuric Acids; Chlorothiazide; Female; Glomerular Filtration Rate; Humans; Inulin; Kidney; Male; Middle Aged; Natriuresis; Phosphates; Phosphorus; Probenecid; Pyrazinamide; Sodium; Uric Acid; Urination | 1973 |
Evidence for a postsecretory reabsorptive site for uric acid in man.
Topics: Absorption; Adult; Aspirin; Female; Humans; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Sulfinpyrazone; Uric Acid | 1973 |
Pyrazinoate excretion in the chimpanzee. Relation to urate disposition and the actions of uricosuric drugs.
Topics: Allopurinol; Aminohippuric Acids; Animals; Biological Transport; Carboxylic Acids; Chlorothiazide; Depression, Chemical; Glomerular Filtration Rate; Insulin; Iodopyracet; Kidney Tubules; Male; Organomercury Compounds; Pan troglodytes; Probenecid; Protein Binding; Pyrazines; Salicylates; Stimulation, Chemical; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1973 |
Active accumulation of 14C-salicylic acid by rat kidney cortex in vitro.
Topics: Aminohippuric Acids; Anaerobiosis; Animals; Benzoates; Carbon Isotopes; Gentisates; In Vitro Techniques; Kidney; Kidney Cortex; Male; Oxidation-Reduction; Probenecid; Rats; Salicylates; Temperature; Time Factors; Uric Acid | 1973 |
Renal synthesis of uric acid.
Topics: Allopurinol; Aminohippuric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Chickens; Chromatography, Thin Layer; Diuresis; Female; Glomerular Filtration Rate; Kidney; Kidney Tubules; Models, Biological; Oxidation-Reduction; Probenecid; Quinine; Uric Acid; Xanthines | 1973 |
Fluid secretion in isolated proximal straight renal tubules. Effect of human uremic serum.
Topics: Acetates; Aminohippuric Acids; Animals; Benzoates; Blood Urea Nitrogen; Creatinine; Female; Guanidines; Humans; Kidney Failure, Chronic; Kidney Tubules; Kidney Tubules, Proximal; Lactates; Male; Ouabain; Perfusion; Probenecid; Rabbits; Succinates; Time Factors; Urea; Uremia; Uric Acid | 1973 |
Gout.
Topics: Allopurinol; Blood Cell Count; Cell Movement; Colchicine; Diet; Drug Synergism; Gastrointestinal Diseases; Gout; Hemorrhage; Humans; Indomethacin; Leukocytes; Mercaptopurine; Phenylbutazone; Probenecid; Purines; Uric Acid | 1974 |
The binding of urate to plasma proteins.
Topics: Allopurinol; Aspirin; Binding Sites; Blood Proteins; Colchicine; Dialysis; Evaluation Studies as Topic; Gout; Humans; Hydrogen-Ion Concentration; Indomethacin; Kidney Diseases; Kinetics; Methods; Osmolar Concentration; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Solubility; Sulfinpyrazone; Temperature; Time Factors; Uric Acid | 1974 |
Suppression of uric acid secretion in a patient with renal hypouricemia.
Topics: Circadian Rhythm; Creatinine; Female; Humans; Kidney Diseases; Middle Aged; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Salicylates; Time Factors; Uric Acid | 1974 |
Reevaluation of the pyrazinamide suppression test.
Topics: Evaluation Studies as Topic; Glomerular Filtration Rate; Male; Methods; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid | 1974 |
Evidence for a post-secretory reabsorptive site for uric acid in man.
Topics: Aspirin; Biological Transport; Fasting; Humans; Kidney Tubules; Probenecid; Pyrazinamide; Sulfinpyrazone; Time Factors; Uric Acid | 1974 |
Is uric acid transported by the hippurate transport system?
Topics: Acetates; Animals; Bile; Biological Transport; Carbon Radioisotopes; Hippurates; Hypoxia; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Tubules; Liver; Probenecid; Rabbits; Rats; Uric Acid | 1974 |
[Pharmacology--patient care].
Topics: Allopurinol; Drug Therapy; History, 19th Century; History, 20th Century; History, Medieval; History, Modern 1601-; Humans; Kidney; Pharmacology; Pharmacopoeias as Topic; Probenecid; Uric Acid | 1971 |
Urate clearance in Cebus monkeys.
Topics: Animals; Chlorothiazide; Cobalt Isotopes; Creatinine; Glomerular Filtration Rate; Haplorhini; Hydroxybutyrates; Inulin; Kidney; Lactates; Probenecid; Sulfinpyrazone; Uric Acid; Vitamin B 12 | 1968 |
Chlorothiazide and probenecid in the treatment of hypertension and hyperuricemia.
Topics: Chlorothiazide; Female; Glucose Tolerance Test; Humans; Hypertension; Male; Middle Aged; Probenecid; Uric Acid | 1968 |
Functional characteristics of renal urate transport in the Cebus monkey.
Topics: Absorption; Aminohippuric Acids; Animals; Biological Transport; Dinitrophenols; Female; Glomerular Filtration Rate; Haplorhini; Hydroxybutyrates; Inulin; Kidney; Kidney Tubules; Lactates; Male; Probenecid; Pyrazines; Regional Blood Flow; Stimulation, Chemical; Uric Acid | 1970 |
Renal effects of uricosuric agents in the Cebus monkey.
Topics: Administration, Oral; Amides; Aminohippuric Acids; Animals; Biotransformation; Chlorothiazide; Glomerular Filtration Rate; Haplorhini; Injections, Intravenous; Inulin; Iodopyracet; Kidney; Phenylbutazone; Probenecid; Species Specificity; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Zoxazolamine | 1970 |
Medical management of gout.
Topics: Adult; Allopurinol; Colchicine; Diet Therapy; Female; Gout; Humans; Kidney Diseases; Male; Middle Aged; Oxyphenbutazone; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1972 |
Metabolites of probenecid. Chemical, physical, and pharmacological studies.
Topics: 1-Propanol; Amino Alcohols; Animals; Benzoates; Blood Proteins; Carbon Isotopes; Dealkylation; Dogs; Female; Humans; Kidney; Liver; Magnetic Resonance Spectroscopy; Male; Probenecid; Propylamines; Protein Binding; Rats; Rats, Inbred Strains; Spectrum Analysis; Structure-Activity Relationship; Ultraviolet Rays; Uric Acid | 1972 |
[Treatment of congenital hyperuricemia].
Topics: Adolescent; Allopurinol; Athetosis; Child; Humans; Hypoxanthines; Intellectual Disability; Lesch-Nyhan Syndrome; Male; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyelonephritis; Self Mutilation; Uric Acid; Urinary Calculi; Xanthines | 1971 |
[Pharmacological studies of diuretics. 4. Changes of serum uric acid level by the succesive administration of thiazide diuretics and other drugs and effects of uricosuric drugs].
Topics: Administration, Oral; Allopurinol; Ammonium Chloride; Animals; Barbiturates; Blood Glucose; Chlorothiazide; Cyclohexanes; Diuretics; Electrolytes; Ethacrynic Acid; Glycine; Hydrochlorothiazide; Hydroflumethiazide; Injections, Subcutaneous; Male; Nucleosides; Phenylbutazone; Probenecid; Quinolines; Rats; Sulfinpyrazone; Sulfonamides; Thiadiazines; Uric Acid; Uricosuric Agents; Xanthenes | 1971 |
The mechanism of urate transport in rabbit kidney tubules in vitro.
Topics: Aminohippuric Acids; Animals; Carbon Isotopes; Dinitrophenols; Female; In Vitro Techniques; Kidney Tubules; Male; Probenecid; Rabbits; Spectrophotometry; Uric Acid | 1971 |
[Effect of transtubular transport inhibitors in the renal excretion of uric acid in the rat].
Topics: Aminohippuric Acids; Animals; Hydrochlorothiazide; Kidney; Kidney Tubules; Male; Metabolic Clearance Rate; Probenecid; Rats; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1971 |
[Podagric arthropathy].
Topics: Adolescent; Adult; Albuminuria; Algeria; Cardiovascular Diseases; Child; Child, Preschool; Cholesterol; Colchicine; Cortisone; Diet; Female; Fructose; Gout; Humans; Male; Middle Aged; Perfusion; Pregnancy; Probenecid; Toe Joint; Uric Acid; Vitamins | 1971 |
Studies on renal urate secretion in the dog.
Topics: Aminohippuric Acids; Animals; Carbon Isotopes; Chlormerodrin; Chlorothiazide; Dogs; Ethacrynic Acid; Female; Furosemide; Inulin; Kidney; Lactates; Male; Probenecid; Pyrazines; Renal Artery; Time Factors; Tritium; Uric Acid | 1971 |
[Uricosuric agents].
Topics: Adult; Benzofurans; Coumarins; Humans; Indenes; Kidney Function Tests; Middle Aged; Probenecid; Uric Acid; Uricosuric Agents; Zoxazolamine | 1971 |
Effects of probenecid and haemodialysis on human parotid fluid uric acid.
Topics: Adolescent; Adult; Humans; Male; Parotid Gland; Probenecid; Renal Dialysis; Saliva; Uric Acid; Uricosuric Agents | 1967 |
Gout of the temporomandibular joint. Report of three cases.
Topics: Colchicine; Diagnosis, Differential; Gout; Humans; Male; Middle Aged; Probenecid; Temporomandibular Joint; Temporomandibular Joint Dysfunction Syndrome; Uric Acid | 1969 |
Drug-induced hyperuricemia prevented by probenecid.
Topics: Adult; Aged; Female; Gout; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Probenecid; Uric Acid | 1971 |
Parotid fluid uric acid responses to probenecid administration and to hemodialysis on the artificial kidney. SAM-TR-66-37.
Topics: Blood; Humans; Kidneys, Artificial; Male; Parotid Gland; Probenecid; Uric Acid | 1966 |
Effect of uricosuric drug administration on uric acid levels in unstimulated parotid fluid. SAM-TR-67-31.
Topics: Adolescent; Adult; Humans; Male; Parotid Gland; Probenecid; Saliva; Uric Acid | 1967 |
[Gout from the view of a special hospital for rheumatic patients].
Topics: Acute Disease; Adolescent; Adult; Aged; Austria; Child; Cholesterol; Colchicine; Colic; Diabetes Complications; Diagnosis, Differential; Diagnostic Errors; Gout; Heart Diseases; Hospitals, Special; Humans; Indomethacin; Kidney Diseases; Middle Aged; Obesity; Phenylbutazone; Probenecid; Prognosis; Radiography; Rheumatic Diseases; Sulfinpyrazone; Time Factors; Uric Acid; Uricosuric Agents | 1971 |
[Renal excretion of uric acid in rats].
Topics: Animals; Glomerular Filtration Rate; Hydrochlorothiazide; Kidney Concentrating Ability; Probenecid; Rats; Sulfinpyrazone; Uric Acid | 1969 |
Effect of drugs on the binding of urate to human albumin.
Topics: Allopurinol; Aspirin; Colchicine; Humans; Indomethacin; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Sulfinpyrazone; Uric Acid | 1970 |
Effect of some uricosuric and anti-inflammatory drugs on the binding of uric acid to human serum albumin in vitro.
Topics: Allopurinol; Anti-Inflammatory Agents; Aspirin; Binding Sites; Caprylates; Colchicine; Dialysis; Fluorescence; Humans; In Vitro Techniques; Indomethacin; Mefenamic Acid; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Sodium Salicylate; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1970 |
Factors affecting the binding of urate to plasma proteins.
Topics: Aspirin; Blood Proteins; Dialysis; Humans; Hydrogen-Ion Concentration; Methods; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Temperature; Uric Acid | 1970 |
Pathogenesis and medical management of chronic gouty arthritis.
Topics: Allopurinol; Chronic Disease; Colchicine; Gout; Humans; Joints; Kidney; Probenecid; Sulfinpyrazone; Uric Acid | 1970 |
Effect of glycine loading on plasma and urinary uric acid and amino acids in normal and gouty subjects.
Topics: Adult; Aged; Amino Acids; Glycine; Gout; Humans; Hydrogen-Ion Concentration; Kidney; Male; Middle Aged; Probenecid; Quaternary Ammonium Compounds; Uric Acid; Urine | 1970 |
The influence of allopurinol on the course of gout. A study of 28 cases.
Topics: Age Factors; Allopurinol; Colchicine; Drug Synergism; Gout; Humans; Probenecid; Uric Acid | 1970 |
The effects of probenecid and thiazides and their combination on the urinary excretion of electrolytes and on acid-base equilibrium.
Topics: Acid-Base Equilibrium; Bicarbonates; Calcium; Calcium Metabolism Disorders; Chlorides; Citrates; Drug Synergism; Humans; Hydrochlorothiazide; Hydrogen-Ion Concentration; Kidney Calculi; Magnesium; Male; Natriuresis; Phosphorus; Potassium; Probenecid; Uric Acid | 1970 |
[Allopurinol in the treatment of gout].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Probenecid; Uric Acid | 1970 |
[Effect of benzbromaronum on the renal uric acid excretion in healthy persons].
Topics: Adult; Benzofurans; Creatinine; Female; Humans; Ketones; Male; Metabolic Clearance Rate; Middle Aged; Probenecid; Protein Binding; Uric Acid; Uricosuric Agents | 1970 |
Renal urate transport in the chimpanzee.
Topics: Aminohippuric Acids; Animals; Creatinine; Diuresis; Glomerular Filtration Rate; Hominidae; Inulin; Kidney; Kidney Function Tests; Kidney Tubules; Male; Osmolar Concentration; Phlorhizin; Probenecid; Pyrazines; Spectrophotometry; Uric Acid | 1971 |
Renal effects of uricosuric agents in the chimpanzee.
Topics: Aminohippuric Acids; Animals; Benzoates; Benzyl Compounds; Chlorothiazide; Electrolytes; Glomerular Filtration Rate; Hominidae; Hydrochlorothiazide; Inulin; Iodopyracet; Kidney; Male; Probenecid; Sodium Salicylate; Sulfinpyrazone; Sulfonamides; Uric Acid; Uricosuric Agents; Zoxazolamine | 1971 |
Hyperlipoproteinaemia in gout.
Topics: Adult; Aged; Allopurinol; Blood Protein Disorders; Blood Protein Electrophoresis; Cholesterol; Gout; Humans; Hyperlipidemias; Lipoproteins; Male; Middle Aged; Probenecid; Prognosis; Triglycerides; Uric Acid | 1971 |
[Ethamide--a drug for the therapy of gout and other conditions associated with accumulation of uric acid in the body].
Topics: Adult; Aged; Female; Gout; Humans; Male; Probenecid; Toe Joint; Uric Acid | 1967 |
Renal transport of uric acid in the guinea pig.
Topics: Absorption; Animals; Biological Transport; Chlorothiazide; Depression, Chemical; Female; Guinea Pigs; Inulin; Kidney Tubules; Lactates; Male; Ouabain; Probenecid; Pyrazines; Uric Acid | 1968 |
Renal clearance of oxipurinol, the chief metabolite of allopurinol.
Topics: Allopurinol; Animals; Dogs; Gout; Humans; Kidney; Kidney Function Tests; Probenecid; Spectrophotometry; Uric Acid | 1968 |
Renal excretion of uric acid in the dog.
Topics: Animals; Biological Transport, Active; Creatinine; Dogs; Female; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Inulin; Kidney; Kidney Tubules; Probenecid; Pyrazines; Species Specificity; Uric Acid | 1968 |
Etiology and treatment of gout--modern concepts.
Topics: Allopurinol; Colchicine; Crystallization; Diagnosis, Differential; Diet Therapy; Gout; Humans; Indomethacin; Joint Diseases; Kidney Diseases; Kidneys, Artificial; Phenylbutazone; Probenecid; Proteinuria; Purines; Radiography; Salicylates; Steroids; Sulfinpyrazone; Uric Acid | 1968 |
A short trial assessment of uricosuric therapy in gout.
Topics: Adult; Aged; Allopurinol; Female; Glomerular Filtration Rate; Gout; Humans; Male; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid | 1968 |
[Allopurinol in the treatment of gout].
Topics: Adult; Allopurinol; Gout; Humans; Indomethacin; Male; Middle Aged; Probenecid; Uric Acid | 1968 |
[Therapy of gout in surgical patients].
Topics: Achilles Tendon; Allopurinol; Cortisone; Diagnosis, Differential; Gout; Humans; Joint Diseases; Male; Middle Aged; Probenecid; Surgical Procedures, Operative; Tendinopathy; Uric Acid | 1968 |
Gout and uveitis. Report of a case.
Topics: Adult; Colchicine; Gout; Humans; Male; Probenecid; Steroids; Uric Acid; Uveitis | 1968 |
[Gout in advanced age].
Topics: Age Factors; Aged; Allopurinol; Bone and Bones; Cardiovascular Diseases; Colchicine; Female; Gout; Humans; Hyperlipidemias; Hypertension; Kidney Diseases; Male; Probenecid; Sodium; Sulfinpyrazone; Uric Acid | 1968 |
The efflux of urate from rabbit renal cortex slices.
Topics: Acetates; Aminohippuric Acids; Animals; Calcium; Dinitrophenols; In Vitro Techniques; Kidney; Potassium; Probenecid; Rabbits; Succinates; Temperature; Uric Acid | 1965 |
The effect of diazoxide, potassium chloride, and ammonium chloride on serum and urinary uric acid.
Topics: Ammonium Chloride; Antihypertensive Agents; Blood; Chlorothiazide; Diazoxide; Humans; Potassium Chloride; Probenecid; Uric Acid; Urine | 1965 |
[On the determination of uricosuric activity in the rat].
Topics: Animals; Colchicine; Phenylbutazone; Probenecid; Rats; Uric Acid | 1965 |
Gout in orthopaedic practice: review of 232 cases.
Topics: Acute Disease; Adolescent; Aged; Bone Diseases; Chlorothiazide; Colchicine; Diagnosis, Differential; Diet; Female; Gout; Humans; Male; Middle Aged; Osteoarthritis; Prednisolone; Probenecid; Radiography; Uric Acid | 1963 |
[Surgical treatment of hands severely deformed by gout].
Topics: Aged; Blood Vessels; Colchicine; Gout; Hand; Hand Deformities, Acquired; Humans; Male; Preoperative Care; Probenecid; Uric Acid | 1965 |
Clearance experiments on the effect of probenecid on urate excretion in the rabbit.
Topics: Animals; Kidney; Male; Probenecid; Rabbits; Uric Acid | 1965 |
The tubular site of urate transport in the rabbit kidney, and the effect of probenecid on urate secretion.
Topics: Aminohippuric Acids; Animals; Biological Transport; Chromatography, Paper; Creatine; Inulin; Kidney Tubules; Male; Probenecid; Rabbits; Uric Acid | 1965 |
Blood-brain and CSF barriers to penicillin and related organic acids.
Topics: Acetates; Aminohippuric Acids; Animals; Blood-Brain Barrier; Carbon Isotopes; Cerebrospinal Fluid; Dogs; In Vitro Techniques; Injections, Intravenous; Penicillin G; Phenolphthaleins; Probenecid; Protein Binding; Radiometry; Rats; Uric Acid | 1966 |
The effects of allopurinol on serum and urinary uric acid.
Topics: Adult; Aged; Blood; Enzymes; Female; Gout; Humans; Male; Probenecid; Uric Acid; Urinary Calculi; Urine; Xanthine Oxidase | 1966 |
Drug control of diuretic-induced hyperuricemia.
Topics: Blood; Chlorothiazide; Humans; Hydrochlorothiazide; Hypertension; Probenecid; Sulfonamides; Uric Acid | 1966 |
Allopurinol (xanthine oxidase inhibitor) in the treatment of resistant gout.
Topics: Adult; Aged; Colchicine; Enzyme Therapy; Enzymes; Female; Gout; Humans; Male; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Allopurinol therapy of gout with renal complications.
Topics: Adult; Allopurinol; Calcium; Creatine; Enzyme Therapy; Gout; Humans; Kidney Failure, Chronic; Male; Middle Aged; Probenecid; Uric Acid; Xanthine Oxidase | 1966 |
[Clinical aspects of chronic gout].
Topics: Adult; Aged; Allopurinol; Anemia; Arthritis; Bicarbonates; Blood Sedimentation; Chronic Disease; Female; Gout; Humans; Joint Diseases; Male; Middle Aged; Phenylbutazone; Physical Exertion; Probenecid; Uric Acid | 1966 |
Effect of food, fast and alcohol on serum uric acid and acute attacks of gout.
Topics: Adult; Aged; Butyrates; Dietary Proteins; Ethanol; Fasting; Female; Gout; Humans; Ketones; Lactates; Male; Middle Aged; Probenecid; Purines; Uric Acid | 1967 |
Hyperuricemia and mental retardation with athetosis and self-mutilation.
Topics: Allopurinol; Athetosis; Body Height; Body Weight; Child; Child, Preschool; Chorea; Humans; Infant; Intellectual Disability; Male; Probenecid; Self Mutilation; Uric Acid; Xanthine Oxidase | 1967 |
Studies of uric acid metabolism in glycogen storage disease associated with gouty arthritis.
Topics: Adolescent; Allopurinol; Body Height; Body Weight; Carbon Isotopes; Enzyme Therapy; Glucosephosphate Dehydrogenase Deficiency; Glycine; Gout; Hepatomegaly; Humans; Male; Probenecid; Radiochemistry; Uric Acid; Xanthine Oxidase | 1967 |
Kinetics of uric acid transport and its production in rat small intestine.
Topics: Animals; Biological Transport, Active; Carbon Isotopes; Chromatography, Paper; Female; Hypoxanthines; Intestine, Small; Kinetics; Probenecid; Rats; Spectrophotometry; Sulfinpyrazone; Uric Acid | 1967 |
The renal accumulation of urate and p-aminohippurate in the rabbit.
Topics: Acids; Aminohippuric Acids; Animals; Dinitrophenols; Inulin; Kidney; Male; Probenecid; Rabbits; Salicylates; Uric Acid | 1967 |
Efflux of probenecid-14-C from surviving rabbit renal cortex slices.
Topics: Acetates; Aminohippuric Acids; Animals; Biological Transport, Active; Caprylates; Carbon Isotopes; Chloromercuribenzoates; Dinitrophenols; In Vitro Techniques; Iodoacetates; Kidney; Probenecid; Rabbits; Succinates; Uric Acid | 1967 |
Allupurinol and diuretic associated hyperuricaemia.
Topics: Allopurinol; Diuretics; Humans; Probenecid; Uric Acid; Uricosuric Agents | 1980 |
Management of gout and hyperuricemia.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Gout; Humans; Indomethacin; Kidney; Patient Education as Topic; Phenylbutazone; Phosphoribosyl Pyrophosphate; Probenecid; Purines; Uric Acid; Uricosuric Agents | 1984 |
Crystal-induced arthritis.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents; Arthritis; Calcium Pyrophosphate; Crystallization; Durapatite; Gout; Humans; Hydroxyapatites; Knee; Leukocytes; Middle Aged; Phagocytosis; Probenecid; Radiography; Synovial Fluid; Uric Acid; Wrist | 1982 |
Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Aminohippuric Acids; Animals; Biological Transport; Carbon Radioisotopes; Cell Membrane; Furosemide; Hydrogen-Ion Concentration; Kidney Cortex; Kinetics; Microvilli; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Tritium; Uric Acid | 1983 |
Decreased renal excretion of uric acid following diuretic administration in rats.
Topics: Animals; Diuretics; Furosemide; Insulin; Male; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Trichlormethiazide; Uric Acid | 1984 |
A microelectrode for continuous monitoring of redox activity in isolated perfused tubule segments.
Topics: Animals; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Proximal; Mice; Mice, Inbred Strains; Microelectrodes; Monitoring, Physiologic; Oxidation-Reduction; Perfusion; Platinum; Probenecid; Pyrazinamide; Uric Acid | 1984 |
The uricosuric action of azapropazone: dose-response and comparison with probenecid.
Topics: Apazone; Creatinine; Diet; Dose-Response Relationship, Drug; Humans; Probenecid; Purines; Triazines; Uric Acid; Uricosuric Agents | 1984 |
Renal handling of uric acid in normal subjects by means of the pyrazinamide and probenecid tests.
Topics: Adult; Glomerular Filtration Rate; Homeostasis; Humans; Kidney; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1983 |
Effects of uricosuric drugs and diuretics on uric acid excretion in oxonate-treated rats.
Topics: Animals; Diuretics; Kidney; Male; Oxonic Acid; Probenecid; Rats; Rats, Inbred Strains; Triazines; Uric Acid; Uricosuric Agents | 1983 |
Regulation of urinary thromboxane B2 in man: influence of urinary flow rate and tubular transport.
Topics: Adult; Angiotensin II; Female; Humans; Kidney; Kidney Tubules; Male; Middle Aged; Probenecid; Thromboxane B2; Thromboxanes; Tritium; Uric Acid; Vasopressins | 1984 |
Renal handling of uric acid in gout by means of the pyrazinamide and probenecid tests.
Topics: Adult; Gout; Humans; Kidney; Kidney Tubules; Probenecid; Pyrazinamide; Reference Values; Uric Acid | 1984 |
[A case of familial renal hypouricemia associated with bladder cancer].
Topics: Aged; Benzbromarone; Carcinoma, Transitional Cell; Humans; Male; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid; Urinary Bladder Neoplasms | 1984 |
Evaluation of the effects of cephaloridine on urate excretion in the rat.
Topics: Animals; Cephaloridine; Female; Kidney; Probenecid; Rats; Rats, Inbred Strains; Time Factors; Uric Acid | 1983 |
Urate transport via anion exchange in dog renal microvillus membrane vesicles.
Topics: Animals; Biological Transport; Chlorides; Dogs; Glucose; Hydrogen-Ion Concentration; Ion Exchange; Kidney Cortex; Microvilli; p-Aminohippuric Acid; Potassium; Probenecid; Uric Acid; Valinomycin | 1983 |
Calciuric effect of probenecid in gouty patients.
Topics: Adult; Aged; Calcium; Creatinine; Gout; Humans; Male; Middle Aged; Probenecid; Uric Acid | 1983 |
Hypouricemia due to an isolated defect in renal tubular urate reabsorption.
Topics: Adult; beta 2-Microglobulin; Chronic Disease; Glomerulonephritis; Humans; Kidney; Male; Phosphates; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Uric Acid | 1980 |
Comparative accumulation of uric acid and hypoxanthine by slices of avian renal cortex.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Animals; Cations; Chickens; Female; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Kidney Cortex; Nitrogen; Probenecid; Sodium Cyanide; Uric Acid | 1982 |
[Renal physiopathology of uric acid. Pharmacologic study].
Topics: Humans; Kidney Diseases; Kidney Tubules; Probenecid; Pyrazinamide; Uric Acid; Uricosuric Agents | 1982 |
A case of familial renal hypouricemia associated with increased secretion of para-aminohippurate and idiopathic edema.
Topics: Adult; Aged; Aminohippuric Acids; Edema; Female; Humans; Kidney Function Tests; Male; p-Aminohippuric Acid; Pedigree; Probenecid; Pyrazinamide; Renal Tubular Transport, Inborn Errors; Saline Solution, Hypertonic; Ticrynafen; Uric Acid | 1982 |
Hypouricemia due to an increment in renal tubular urate secretion.
Topics: Adult; Female; Humans; Kidney Tubules; Metabolic Clearance Rate; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1982 |
Hyperuricemia: a possible etiologic factor in chronic recurrent parotitis.
Topics: Adult; Chronic Disease; Humans; Male; Parotitis; Probenecid; Uric Acid | 1982 |
[Effect of long-term base therapy on the clinical picture of gout].
Topics: Adult; Allopurinol; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Female; Gout; Humans; Male; Middle Aged; Probenecid; Sulfinpyrazone; Time Factors; Uric Acid | 1981 |
Treatment of gout.
Topics: Gout; Humans; Probenecid; Uric Acid; Uricosuric Agents | 1981 |
Selected physiologic and drug effects on serum uric acid levels in an elderly population.
Topics: Aged; Allopurinol; Diuretics; Female; Humans; Hypertension; Male; Obesity; Probenecid; Thyroid Diseases; Uric Acid | 1981 |
[Paraneoplastic hypouricemia in Hodgkin's lymphoma secondary to a renal tubular reabsorption defect of uric acid (author's transl)].
Topics: Adult; Hodgkin Disease; Humans; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid | 1981 |
Diagnostic and therapeutic aids in gout and hyperuricemia.
Topics: Acute Disease; Allopurinol; Arthritis, Rheumatoid; Colchicine; Diagnosis, Differential; Gout; Humans; Probenecid; Uremia; Uric Acid; Uricosuric Agents | 1981 |
Effects of exercise performance on drugs used in musculoskeletal disorders.
Topics: Allopurinol; Analgesics; Anti-Inflammatory Agents; Bone Diseases; Colchicine; Gout; Humans; Muscle Relaxants, Central; Muscular Diseases; Physical Exertion; Probenecid; Prostaglandins; Uric Acid | 1981 |
Renal pathogenesis of familial hyperuricemia: studies in two kindreds.
Topics: Adolescent; Ascorbic Acid; Humans; Kidney; Kidney Tubules; Male; Probenecid; Protein Binding; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Uric Acid | 1981 |
Nature of urate transport in isolated rabbit proximal tubules.
Topics: Animals; Biological Transport; Female; Glucose; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Perfusion; Probenecid; Rabbits; Uric Acid | 1981 |
Uptake of [3H]PAH and [14C]urate into isolated proximal tubular segments of the pig kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport, Active; Female; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; p-Aminohippuric Acid; Probenecid; Pyrazinamide; Swine; Uric Acid | 1981 |
Effect of ibuprofen or aspirin on probenecid-induced uricosuria.
Topics: Adult; Aspirin; Creatinine; Female; Humans; Ibuprofen; Male; Pilot Projects; Probenecid; Uric Acid | 1980 |
Stopped-flow microperfusion studies of urate absorption from the rat proximal tubule.
Topics: Absorption; Animals; Kidney Tubules, Proximal; Male; Methods; Perfusion; Probenecid; Rats; Time Factors; Uric Acid | 1980 |
Urate metabolism in a mongrel dog.
Topics: Allantoin; Animals; Carbon Radioisotopes; Dogs; Probenecid; Pyrazinamide; Salicylates; Uric Acid | 1980 |
Secretion of urate in the proximal convoluted tubule of the rat.
Topics: Animals; Chloromercuribenzoates; Kidney Tubules, Proximal; Male; Potassium; Probenecid; Rats; Secretory Rate; Uric Acid | 1980 |
Accumulation of [14C]urate and [3H]PAH in isolated proximal tubular segments of the rabbit kidney.
Topics: Aminohippuric Acids; Animals; Biological Transport; Carbon Radioisotopes; Female; In Vitro Techniques; Kidney Tubules, Proximal; Male; p-Aminohippuric Acid; Perfusion; Probenecid; Pyrazinamide; Rabbits; Tritium; Uric Acid | 1980 |
Urate secretion in isolated rabbit renal tubules.
Topics: Animals; Female; Kidney Tubules; Kidney Tubules, Collecting; Kidney Tubules, Proximal; Ouabain; Probenecid; Rabbits; Uric Acid | 1980 |
The uricosuric effect in rats of E5050, a new derivative of ethanolamine, involves inhibition of the tubular postsecretory reabsorption of urate.
Topics: Animals; Dose-Response Relationship, Drug; Ethanolamine; Ethanolamines; Male; Probenecid; Rats; Rats, Wistar; Time Factors; Uric Acid; Uricosuric Agents | 1995 |
Impairment of tubular secretion of urate in renal transplant patients on cyclosporine.
Topics: Adult; Benzofurans; Cyclosporine; Female; Humans; Kidney Transplantation; Kidney Tubules; Male; Middle Aged; Prevalence; Probenecid; Pyrazinamide; Retrospective Studies; Uric Acid; Uricosuric Agents | 1995 |
Effect of nifedipine on tubular handling of uric acid in transplanted kidney on cyclosporine A treatment.
Topics: Adolescent; Adult; Child; Creatinine; Cyclosporine; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Ion Transport; Kidney Diseases; Kidney Transplantation; Kidney Tubules; Male; Nifedipine; Probenecid; Uric Acid | 1995 |
Pharmacologic evaluation of the renal handling of uric acid and oxypurines.
Topics: Adult; Benzbromarone; Biological Transport; Humans; Hypoxanthine; Hypoxanthines; Kidney Tubules; Male; Probenecid; Pyrazinamide; Uric Acid; Xanthines | 1994 |
Renal hypouricemia: incomplete combined defect.
Topics: Adult; Benzbromarone; Calcium; Humans; Male; Nephrosis, Lipoid; Probenecid; Pyrazinamide; Uric Acid | 1994 |
Urate transport in brush-border membrane of human kidney.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Aged; Biological Transport; Carbon Radioisotopes; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Humans; Hydroxybutyrates; Kidney Cortex; Kidney Neoplasms; Kinetics; Lactates; Microvilli; Middle Aged; p-Aminohippuric Acid; Probenecid; Uric Acid; Valinomycin | 1994 |
Hypouricemia due to increased tubular secretion of urate in children with Amanita phalloides poisoning.
Topics: Adolescent; Amanita; Biological Transport, Active; Child; Child, Preschool; Female; Humans; Kidney Tubules; Male; Mushroom Poisoning; Probenecid; Pyrazinamide; Uric Acid | 1993 |
Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate.
Topics: Benzbromarone; Citrates; Creatinine; Female; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Kidney Tubules; Middle Aged; Probenecid; Pyrazinamide; Uric Acid; Urinary Calculi | 1993 |
Evidence of defective tubular reabsorption and normal secretion of uric acid in the syndrome of inappropriate secretion of antidiuretic hormone.
Topics: Absorption; Aged; Female; Humans; Inappropriate ADH Syndrome; Kidney Tubules; Male; Middle Aged; Probenecid; Pyrazinamide; Uric Acid | 1993 |
Nasal secretion of the ozone scavenger uric acid.
Topics: Albumins; Antioxidants; Humans; Lactoferrin; Methacholine Chloride; Muramidase; Nasal Mucosa; Nasal Provocation Tests; Ozone; Plasma; Probenecid; Turbinates; Uric Acid; Xanthine Oxidase | 1993 |
Preparation and biological characteristics of 99mTc-diol a renal agent.
Topics: Acid-Base Imbalance; Animals; Autoradiography; Blood Proteins; Chemical Phenomena; Chemistry, Physical; Female; Fosfomycin; Hydrolysis; Kidney; Magnetic Resonance Spectroscopy; Male; Mice; Organophosphonates; Organotechnetium Compounds; Probenecid; Protein Binding; Radionuclide Imaging; Rats; Reagent Kits, Diagnostic; Tissue Distribution; Uric Acid | 1993 |
Renal handling of urate in a patient with familial juvenile gouty nephropathy.
Topics: Adolescent; Benzbromarone; Female; Genes, Dominant; Gout; Gout Suppressants; Humans; Kidney; Kidney Failure, Chronic; Male; Pedigree; Probenecid; Pyrazinamide; Renal Agents; Uric Acid; Uricosuric Agents | 1996 |
Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.
Topics: Aged; Benzbromarone; Biological Transport; Biphenyl Compounds; Carbon Radioisotopes; Diuretics; Ethambutol; Humans; Imidazoles; Kidney Cortex; Kidney Neoplasms; Kinetics; Losartan; Microvilli; Middle Aged; Probenecid; Pyrazinamide; Salicylates; Salicylic Acid; Sulfinpyrazone; Tetrazoles; Ticrynafen; Uric Acid; Uricosuric Agents | 1997 |
Calcinosis universalis complicating juvenile dermatomyositis: resolution during probenecid therapy.
Topics: Adult; Bone Density; Calcinosis; Dermatomyositis; Glomerular Filtration Rate; Humans; L-Lactate Dehydrogenase; Male; Parathyroid Hormone; Phosphates; Probenecid; Uric Acid | 1997 |
Gout due to xanthine derivatives.
Topics: Allopurinol; Aminophylline; Asthma; Benzbromarone; Bronchodilator Agents; Drug Therapy, Combination; Female; Gout; Humans; Middle Aged; Probenecid; Theophylline; Uric Acid; Uricosuric Agents | 1997 |
Hematuria in patients with renal hypouricemia.
Topics: Adult; Aged; Aged, 80 and over; Benzbromarone; Creatinine; Female; Hematuria; Humans; Kidney Diseases; Male; Metabolism, Inborn Errors; Middle Aged; Probenecid; Pyrazinamide; Renal Agents; Uric Acid | 1998 |
Apoptosis of tubular epithelial cells in familial juvenile gouty nephropathy.
Topics: Adult; Apoptosis; Benzbromarone; Biopsy; Biotin; Deoxyuracil Nucleotides; DNA Fragmentation; Family Health; Female; Genes, Dominant; Glomerulosclerosis, Focal Segmental; Gout; Humans; Kidney Failure, Chronic; Kidney Tubules, Proximal; Male; Middle Aged; Pedigree; Probenecid; Staining and Labeling; Uremia; Uric Acid; Uricosuric Agents | 1998 |
Restoration of the uricosuric effect of probenecid after triglycylvasopressine administration in a gouty patient.
Topics: Absorption; Acute Kidney Injury; Adult; Anti-Inflammatory Agents; Benzbromarone; Fludrocortisone; Gout; Humans; Kidney Tubules; Lypressin; Male; Probenecid; Pyrazinamide; Receptors, Vasopressin; Renal Agents; Terlipressin; Uric Acid; Uricosuric Agents | 1998 |
[Gout: physiopathology, diagnosis, course, treatment].
Topics: Adult; Aged; Allopurinol; Arthritis, Gouty; Benzbromarone; Diagnosis, Differential; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Probenecid; Synovial Fluid; Uric Acid; Uricosuric Agents | 1998 |
Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats.
Topics: Animals; Biotransformation; Bronchodilator Agents; Infusions, Intravenous; Injections, Intravenous; Male; Nonlinear Dynamics; Probenecid; Rats; Rats, Wistar; Renal Agents; Theophylline; Uric Acid | 1994 |
Exercise-induced acute renal failure in a patient with renal hypouricemia.
Topics: Acute Kidney Injury; Child; Creatinine; Exercise; Follow-Up Studies; Humans; Kidney; Kidney Tubules; Male; Necrosis; Probenecid; Pyrazinamide; Reference Values; Uric Acid | 2000 |
[Hyperuricemia and gout--treatment].
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Colchicine; Drug Therapy, Combination; Glucocorticoids; Gout; Gout Suppressants; Humans; Kidney Calculi; Kidney Diseases; Probenecid; Time Factors; Uric Acid; Uricosuric Agents | 2002 |
Diagnosis and treatment of gouty arthritis.
Topics: Arthritis; Arthritis, Gouty; Colchicine; Gout; Humans; Hyperuricemia; Male; Middle Aged; Probenecid; Purines; Uric Acid; Uricosuric Agents | 1953 |
Metabolism of uric acid and its relation to gout.
Topics: Gout; Humans; Probenecid; Uric Acid | 1954 |
Sodium salicylate and probenecid in the treatment of chronic gout; assessment of their relative effects in lowering serum uric acid levels.
Topics: Arthritis, Gouty; Blood; Chronic Disease; Gout; Humans; Probenecid; Salicylates; Sodium Salicylate; Uric Acid | 1954 |
[Mode of action of benemid on renal mechanism of excretion of uric acid].
Topics: Biological Transport; Body Fluids; Humans; Kidney; Probenecid; Uric Acid | 1954 |
Further observation on the uricosuric effects of probenecid (benemid) in tophaceous gout.
Topics: Body Fluids; Gout; Humans; Probenecid; Uric Acid; Urine | 1954 |
Paradoxical retention of uric acid by uricosuric drugs in low dosage.
Topics: Analgesics; Body Fluids; Humans; Kidney; Probenecid; Salicylates; Uric Acid | 1955 |
Inhibition of uric acid excretion in rabbits given probenecid or salicylic acid.
Topics: Animals; Biological Transport; Body Fluids; Humans; Kidney; Lagomorpha; Probenecid; Rabbits; Salicylic Acid; Uric Acid | 1955 |
The action of probenecid (p-[di-n-propylsulphamyl]-benzoic acid) on uric acid excretion and plasma uric acid level in normal human subjects.
Topics: Benzoic Acid; Biological Transport; Blood; Body Fluids; Humans; Kidney; Plasma; Probenecid; Uric Acid | 1955 |
The mechanism of the increased renal excretion of urate during the administration of probenecid.
Topics: Kidney; Pharmaceutical Preparations; Probenecid; Renal Elimination; Uric Acid | 1955 |
The effect of benemid on uric acid excretion in normal pregnancy and in pre-eclampsia.
Topics: Biological Transport; Body Fluids; Female; Humans; Pre-Eclampsia; Pregnancy; Probenecid; Uric Acid | 1957 |
The effect of probenecid on pyrazinamide blood levels and pyrazinamide-induced hyperuricemia.
Topics: Humans; Hyperuricemia; Niacin; Nicotinic Acids; Probenecid; Pyrazinamide; Uric Acid | 1957 |
The influence of probenecid, phenylbutazone and salicylates upon urate excretion in man.
Topics: Biological Transport; Body Fluids; Humans; Leadership; Male; Phenylbutazone; Probenecid; Salicylates; Uric Acid | 1957 |
Plasma uric acid levels, uric acid excretion, and response to probenecid in toxemia of pregnancy.
Topics: Biological Transport; Body Fluids; Female; Humans; Plasma; Pre-Eclampsia; Pregnancy; Probenecid; Uric Acid | 1958 |
Successful treatment of recurrent uric acid renal calcui with probenecid (benemid).
Topics: Calculi; Humans; Kidney; Kidney Calculi; Probenecid; Uric Acid | 1958 |
[Note on uraturia in gout patients during benemid therapy].
Topics: Body Fluids; Gout; Probenecid; Uric Acid | 1958 |
The effect of simultaneous ingestion of probenecid and phenylbutazone on uric acid excretion and uric acid concentration in the serum.
Topics: Biological Transport; Body Fluids; Eating; Humans; Phenylbutazone; Probenecid; Uric Acid | 1960 |
[Effects of the simultaneous administration of probenecid and phenylbutazone on uric acid excretion and uric acid concentration in blood].
Topics: Humans; Phenylbutazone; Probenecid; Uric Acid | 1960 |
The effect of probenecid on renal excretion and plasma level of uric acid in patients with renal insufficiency.
Topics: Humans; Kidney; Kidney Diseases; Metabolic Diseases; Probenecid; Renal Elimination; Renal Insufficiency; Uric Acid | 1961 |
Long term uricosuric therapy in gout.
Topics: Gout; Phenylbutazone; Probenecid; Salicylates; Uric Acid; Zoxazolamine | 1962 |
Serum uric acid in myocardial infarction.
Topics: Cardiovascular Diseases; Humans; Myocardial Infarction; Probenecid; Uric Acid | 1963 |
[Uricosuria therapy of chronic gout].
Topics: Arthritis; Chronic Disease; Gout; Humans; Probenecid; Uric Acid; Urologic Diseases | 1963 |
[The use of uricosuric agents].
Topics: Gout; Humans; Probenecid; Uric Acid; Uricosuric Agents | 1963 |
Reversal of thiazide-induced transient hyperuricemia by uricosuric agents.
Topics: Chlorthalidone; Humans; Hydrochlorothiazide; Hyperuricemia; Probenecid; Pyrazoles; Thiazides; Uric Acid; Uricosuric Agents | 1962 |
THE EFFECT OF CHLOROTHIAZIDE ON THE EXCRETION OF URIC ACID AND ELECTROLYTES BY THE CHICKEN.
Topics: Animals; Biological Transport; Chickens; Chlorides; Chlorothiazide; Kidney Function Tests; Niacin; Niacinamide; Pharmacology; Potassium; Poultry; Probenecid; Research; Sodium; Uric Acid; Urine | 1963 |
MEDICAL GRAND ROUNDS FROM THE UNIVERSITY OF ALABAMA MEDICAL CENTER.
Topics: Arthritis; Colchicine; Gout; Humans; Phenylbutazone; Probenecid; Teaching Rounds; Uric Acid | 1964 |
ASSOCIATION OF HYPERURICAEMIA AND GOUT WITH HYPERPARATHYROIDISM.
Topics: Adenoma; Blood Chemical Analysis; Diagnosis; Gout; Humans; Hyperparathyroidism; Hyperuricemia; Nephrocalcinosis; Parathyroid Neoplasms; Prednisone; Probenecid; Pyrazinamide; Surgical Procedures, Operative; Uric Acid | 1964 |
URIC ACID EXCRETION IN OBESE SUBJECTS DURING PERIODS OF TOTAL FASTING.
Topics: Acidosis; Basal Metabolism; Blood Glucose; Fasting; Glycine; Humans; Obesity; Pennsylvania; Probenecid; Uric Acid; Urine | 1964 |
THE TREATMENT OF GOUT.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Colchicine; Diet; Diet Therapy; Drug Therapy; Geriatrics; Gout; Kidney Diseases; Metabolism; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Surgical Procedures, Operative; Toxicology; Uric Acid; Uricosuric Agents; Zoxazolamine | 1964 |
GOUT.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Colchicine; Diagnosis, Differential; Diet; Diet Therapy; Drug Therapy; Epidemiology; Genetics, Medical; Gout; Humans; Indomethacin; Kidney Diseases; Kidneys, Artificial; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Uric Acid; Urine | 1964 |
EFFECT OF SULFINPYRAZONE ON SERUM URIC ACID IN GOUT. A LONG-TERM STUDY.
Topics: Adolescent; Aging; Blood; Drug Therapy; Geriatrics; Gout; Longitudinal Studies; Metabolism; Phenylbutazone; Probenecid; Salicylates; Sex; Sulfinpyrazone; Toxicology; Uric Acid | 1964 |
4-HYDROXYPYRAZOLO (3,4-D) PYRIMIDINE (HPP) IN THE TREATMENT OF GOUT: PRELIMINARY OBSERVATIONS.
Topics: Blood; Colchicine; Diet; Diet Therapy; Drug Therapy; Enzyme Inhibitors; Geriatrics; Gout; Humans; Probenecid; Purines; Pyrazoles; Pyrimidines; Toxicology; Uric Acid; Urine; Xanthine Oxidase; Xanthines | 1964 |
EXPERIMENTAL URATE NEROPATHY: STUDIES OF THE DISTRIBUTION OF URATE IN RENAL TISSUE.
Topics: Blood Chemical Analysis; Dogs; Histocytochemistry; Kidney Diseases; Kidney Function Tests; Mannitol; Pharmacology; Probenecid; Research; Uric Acid | 1964 |
DECREASE OF PLASMA URIC ACID CONCENTRATION OF SUBJECTS WITH LEUKEMIA BY BENEMID.
Topics: Blood; Drug Therapy; Humans; Leukemia; Probenecid; Uric Acid | 1964 |
STOP-FLOW ANALYSIS OF TUBULAR TRANSPORT OF URIC ACID IN RABBITS.
Topics: Animals; Biological Transport; Body Fluids; Chlorothiazide; Creatine; Creatinine; Glomerular Filtration Rate; Inulin; Kidney Tubules; Lactates; Metabolism; Pharmacology; Physiology; Probenecid; Pyrazines; Rabbits; Research; Salicylates; Uric Acid; Urine | 1964 |
THE EFFECTS OF STARVATION, HIGH FAT DIETS, AND KETONE INFUSIONS ON URIC ACID BALANCE.
Topics: Blood; Creatine; Creatinine; Diet, High-Fat; Dietary Fats; Fasting; Glucose; Hydrogen-Ion Concentration; Hydroxybutyrates; Ketones; Lactates; Metabolism; Pharmacology; Potassium; Probenecid; Pyruvates; Starvation; Uric Acid; Urine | 1965 |
INFLUENCE OF INORGANIC ELECTROLYTES AND OUABAIN ON URIC ACID TRANSPORT.
Topics: Animals; Biological Transport; Cesium; Electrolytes; Ions; Kidney; Ouabain; Pharmacology; Potassium; Probenecid; Rabbits; Research; Rubidium; Sodium; Uric Acid | 1965 |
[GOUT, DIAGNOSIS AND TREATMENT].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Colchicine; Diagnosis; Drug Therapy; Gout; Humans; Leukocyte Count; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1965 |
URATE DIURETIC THERAPY IN CHRONIC GOUT; A COMPARATIVE STUDY OF PROBENECID AND SULFINPYRAZONE.
Topics: Arthritis, Gouty; Biomedical Research; Blood; Diuretics; Drug Therapy; Gout; Humans; Kidney Calculi; Kidney Function Tests; Probenecid; Sulfinpyrazone; Toxicology; Uric Acid; Urinary Calculi | 1965 |
GOUT IN THE ELDERLY. MODERN MANAGEMENT IN HISTORICAL PERSPECTIVE.
Topics: Aged; Colchicine; Diagnosis; Diet; Diet Therapy; Drug Therapy; Geriatrics; Gout; History; Humans; Phenylbutazone; Probenecid; Salicylates; Toxicology; Uric Acid | 1965 |
Inhibition of the uricosuric action of benemid by salicylate.
Topics: Body Fluids; Gout; Probenecid; Salicylates; Uric Acid; Urine | 1955 |
Immediate uricosuric effect of probenecid in normal humans.
Topics: Humans; Probenecid; Uric Acid; Urine | 1955 |
Effects of probenecid, sodium salicylate, 2,4-dinitrophenol and pyrazinamide on renal secretion of uric acid in chickens.
Topics: 2,4-Dinitrophenol; Animals; Chickens; Dinitrophenols; Kidney; Nitrophenols; Probenecid; Pyrazinamide; Sodium Chloride; Sodium Salicylate; Uric Acid | 1959 |
Benemid, flexin and anturane as uricosuric agents.
Topics: Humans; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Zoxazolamine | 1962 |
Two male siblings with hereditary renal hypouricemia and exercise-induced ARF.
Topics: Acute Kidney Injury; Adult; Back Pain; Carrier Proteins; Codon, Nonsense; Creatinine; Exercise; Exons; Humans; Kidney Function Tests; Male; Metabolism, Inborn Errors; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Pedigree; Probenecid; Pyrazinamide; Running; Uric Acid; Urinary Calculi | 2003 |
The effect of benemid (P-[DI-N-propylsulfamyl]-benzoic acid) on uric acid metabolism in one normal and one gouty subject.
Topics: Benzoic Acid; Gout; Humans; Probenecid; Uric Acid | 1951 |
Benemid (p-di-n-propylsulfamyl)-benzoic acid) as uricosuric agent in chronic gouty arthritis.
Topics: Arthritis, Gouty; Benzoic Acid; Body Fluids; Chronic Disease; Gout; Probenecid; Uric Acid; Uricosuric Agents | 1951 |
The clinical and metabolic effects of benemid in patients with gout.
Topics: Body Fluids; Gout; Probenecid; Uric Acid | 1951 |
Effect of benemid (p-[di-n-propylsulfamyl]-benzoic acid) on urate clearance and other discrete renal functions in gouty subjects.
Topics: Benzoic Acid; Gout; Humans; Kinetics; Probenecid; Uric Acid | 1952 |
The influence of p-(di-n-propylsulfamyl)-benzoic acid on the excretion of uric acid.
Topics: Benzoic Acid; Biological Transport; Body Fluids; Leadership; Probenecid; Uric Acid | 1952 |
Phenolsulfonphthalein transport by potential-sensitive urate transport system.
Topics: Animals; Biological Transport; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane; Chlorides; Dose-Response Relationship, Drug; Ionophores; Kidney; Male; Mannitol; Membrane Potentials; Microvilli; Phenolsulfonphthalein; Potassium Chloride; Probenecid; Pyrazinamide; Rats; Rats, Wistar; Time Factors; Uric Acid; Valinomycin | 2005 |
Transepithelial urate transport by avian renal proximal tubule epithelium in primary culture.
Topics: Animals; Biological Transport, Active; Bromcresol Green; Carbon Radioisotopes; Chickens; Cimetidine; Cytochalasins; DNA Primers; Electric Impedance; Epithelium; Estrone; Glutarates; Hydrogen-Ion Concentration; Kidney Tubules, Proximal; Lithium; Membrane Potentials; Nocodazole; Organic Anion Transporters; Ouabain; p-Aminohippuric Acid; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uric Acid | 2005 |
Febuxostat--treatment for hyperuricemia and gout?
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thiazoles; Uric Acid; Xanthine Oxidase | 2005 |
Human vascular smooth muscle cells express a urate transporter.
Topics: Aorta; Biological Transport; Blotting, Western; Carrier Proteins; Cell Membrane; Cells, Cultured; Humans; Muscle, Smooth, Vascular; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Uric Acid; Uricosuric Agents | 2006 |
Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.
Topics: Benzbromarone; Cell Line; Flavonoids; Humans; Kidney; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Sulfinpyrazone; Transfection; Uric Acid; Uricosuric Agents | 2007 |
Effect of pharmacological lowering of plasma urate on exercise-induced oxidative stress.
Topics: Adolescent; Adult; Anaerobic Threshold; Antioxidants; Ascorbic Acid; Body Composition; Body Weight; Exercise; Ferric Compounds; Humans; Isoprostanes; Lactic Acid; Lipid Peroxidation; Male; Nitrates; Nitrites; Oxidation-Reduction; Oxidative Stress; Probenecid; Uric Acid; Uricosuric Agents | 2007 |
Gout: joint pain and more.
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Gout; Gout Suppressants; Humans; Male; Probenecid; Uric Acid; Uricosuric Agents | 2007 |
Opportunities for improving medication use and monitoring in gout.
Topics: Aged; Allopurinol; Biomarkers; Colchicine; Drug Administration Schedule; Drug Monitoring; Female; Gout; Gout Suppressants; Guideline Adherence; Humans; Male; Middle Aged; Practice Guidelines as Topic; Probenecid; Quality of Health Care; Renal Insufficiency; Treatment Outcome; Uric Acid | 2009 |
Adherence with urate-lowering therapies for the treatment of gout.
Topics: Age Factors; Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid | 2009 |
Ultrasonography shows disappearance of monosodium urate crystal deposition on hyaline cartilage after sustained normouricemia is achieved.
Topics: Aged; Aged, 80 and over; Allopurinol; Cartilage, Articular; Colchicine; Crystallization; Female; Gout; Gout Suppressants; Humans; Hyaline Cartilage; Joints; Male; Middle Aged; Probenecid; Treatment Outcome; Ultrasonography; Uric Acid | 2010 |
On call. I've had gout for many years. I used to take Zyloprim without any problems, but I just had a severe allergic reaction, so my doctor switched me to Benemid. I'm doing okay, but the drug sometimes upsets my stomach. Do you have any suggestions?
Topics: Allopurinol; Drug Hypersensitivity; Gastritis; Gout; Gout Suppressants; Humans; Male; Middle Aged; Probenecid; Uric Acid; Uricosuric Agents | 2010 |
Uric acid increases fibronectin synthesis through upregulation of lysyl oxidase expression in rat renal tubular epithelial cells.
Topics: Animals; Blotting, Western; Cell Line; Disease Models, Animal; Epithelial Cells; Extracellular Matrix Proteins; Fibronectins; Fibrosis; Fluorescent Antibody Technique; Hyperuricemia; Kidney Tubules; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Organic Anion Transporters; Probenecid; Protein-Lysine 6-Oxidase; Rats; RNA Interference; Time Factors; Up-Regulation; Uric Acid | 2010 |
Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Benzothiazoles; Biological Transport; Captopril; Cells, Cultured; Dogs; Enalapril; Indomethacin; Inhibitory Concentration 50; Organic Anion Transporters; Organic Cation Transport Proteins; Phenylbutazone; Probenecid; Pyridines; Salicylates; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 2011 |
Catastrophic axial gout causing paraplegia in a patient with glycogen storage disease.
Topics: Adult; Catastrophic Illness; Drug Therapy, Combination; Febuxostat; Glycogen Storage Disease Type I; Gout; Gout Suppressants; Humans; Magnetic Resonance Imaging; Male; Obesity, Morbid; Paraplegia; Prednisone; Probenecid; Radiography; Synovial Fluid; Thiazoles; Uric Acid | 2011 |
Adherence to uric acid treatment guidelines in a rheumatology clinic.
Topics: Aged; Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Guideline Adherence; Humans; Male; Middle Aged; Probenecid; Retrospective Studies; Thiazoles; Treatment Outcome; Uric Acid | 2012 |
Efficacy and tolerability of probenecid as urate-lowering therapy in gout; clinical experience in high-prevalence population.
Topics: Adult; Aged; Female; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Male; Middle Aged; Probenecid; Treatment Outcome; Uric Acid | 2013 |
Fuzzy optimization for detecting enzyme targets of human uric acid metabolism.
Topics: Algorithms; Diet; Drug Design; Drug Discovery; Fuzzy Logic; Humans; Hyperuricemia; Kinetics; Lesch-Nyhan Syndrome; Metabolic Networks and Pathways; Models, Biological; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribose-Phosphate Pyrophosphokinase; Ribosemonophosphates; Uric Acid; Uricosuric Agents | 2013 |
The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.
Topics: Antioxidants; Biological Transport; Cell Line, Tumor; DNA Damage; Glucose Transport Proteins, Facilitative; Hep G2 Cells; Humans; Neoplasms; Oxidative Stress; Probenecid; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Tumor Suppressor Protein p53; Uric Acid | 2015 |
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Topics: Adenosine Triphosphate; Adjuvants, Pharmaceutic; Allopurinol; Animals; Antimetabolites; Cells, Cultured; Disease Models, Animal; Fatty Liver, Alcoholic; Female; Hepatocytes; Inflammasomes; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Probenecid; Signal Transduction; Uric Acid | 2015 |
Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Inosine; Male; Nitriles; Oxonic Acid; Probenecid; Pyridines; Rats; Rats, Wistar; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Dehydrogenase | 2016 |
Uric acid: a modulator of prostate cells and activin sensitivity.
Topics: Activins; Cell Line, Tumor; Glucose Transport Proteins, Facilitative; Humans; Male; Probenecid; Prostate; Prostatic Neoplasms; RNA, Messenger; Tissue Array Analysis; Transforming Growth Factor beta; Uric Acid | 2016 |
Achieving serum urate targets in gout: an audit in a gout-oriented rheumatology practice.
Topics: Aged; Allopurinol; Biomarkers; Drug Substitution; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Medical Audit; Medication Adherence; Practice Guidelines as Topic; Probenecid; Retrospective Studies; Rheumatology; Time Factors; Treatment Outcome; Uric Acid | 2017 |
Effective uric acid reduction with probenecid and febuxostat in a patient with chronic kidney disease.
Topics: Adult; Chronic Disease; Drug Therapy, Combination; Febuxostat; Foot Deformities, Acquired; Gout; Gout Suppressants; Humans; Male; Probenecid; Renal Insufficiency, Chronic; Severity of Illness Index; Treatment Outcome; Uric Acid | 2018 |
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells.
Topics: Actins; Animals; Antioxidants; Capillaries; Disease Progression; Endothelial Cells; Epithelial-Mesenchymal Transition; Fibrosis; Human Umbilical Vein Endothelial Cells; Humans; Hyperuricemia; Kidney Tubules; Probenecid; Reactive Oxygen Species; Renal Insufficiency, Chronic; Uric Acid; Uricosuric Agents | 2018 |
Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells.
Topics: Apoptosis; Carcinogenesis; Carcinoma, Hepatocellular; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glucose Transport Proteins, Facilitative; Hep G2 Cells; Humans; Liver Neoplasms; Probenecid; Reactive Oxygen Species; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Uric Acid; Uricosuric Agents | 2019 |
Urate-Lowering Therapy in Moderate to Severe Chronic Kidney Disease.
Topics: Aged; Allopurinol; Cohort Studies; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Probenecid; Renal Insufficiency, Chronic; Retrospective Studies; Risk Factors; Severity of Illness Index; Uric Acid; Uricosuric Agents | 2018 |
Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Nutrition Surveys; Prevalence; Probenecid; United States; Uric Acid; Uricosuric Agents; Young Adult | 2019 |
Burden and management of gout in a multi-ethnic Asian cohort.
Topics: Adult; Aged; Allopurinol; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Dyslipidemias; Emergency Service, Hospital; Ethnicity; Febuxostat; Female; Gout; Gout Suppressants; Hospitalization; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Probenecid; Renal Insufficiency, Chronic; Severity of Illness Index; Singapore; Treatment Outcome; Uric Acid | 2020 |
High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout.
Topics: Allopurinol; Animal Structures; Animals; Chickens; Crystallization; Diet, High-Protein; Disease Models, Animal; Gout; Hyperuricemia; Kidney; Liver; Probenecid; Synovial Fluid; Uric Acid | 2020 |
Uric Acid Has Direct Proinflammatory Effects on Human Macrophages by Increasing Proinflammatory Mediators and Bacterial Phagocytosis Probably via URAT1.
Topics: Adolescent; Adult; Cells, Cultured; CX3C Chemokine Receptor 1; Escherichia coli; Humans; Inflammation; Inflammation Mediators; Interleukin-1beta; Lectins, C-Type; Macrophages; Male; Mannose Receptor; Mannose-Binding Lectins; Organic Anion Transporters; Organic Cation Transport Proteins; Phagocytosis; Probenecid; Receptors, CCR2; Receptors, Cell Surface; Tumor Necrosis Factor-alpha; Uric Acid; Young Adult | 2020 |
Characterizations of the Urate Transporter, GLUT9, and Its Potent Inhibitors by Patch-Clamp Technique.
Topics: Animals; Benzbromarone; Biological Transport; Gene Expression; Glucose Transport Proteins, Facilitative; Gout Suppressants; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Naphthalenes; Patch-Clamp Techniques; Plasmids; Potassium; Probenecid; Propionates; Pyridines; Transgenes; Uric Acid | 2021 |
Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Survival; Disease Models, Animal; Glucose; HMGB1 Protein; Inflammation; Inflammation Mediators; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Microglia; NF-kappa B; Oxygen; Probenecid; Signal Transduction; Toll-Like Receptor 4; Uric Acid | 2021 |
Uricosuric Agents Affect Plasma and Kidney Concentration of Adefovir via Inhibition of Oat1 and Mrp2 in Rats.
Topics: Animals; Benzbromarone; Kidney; Organic Anion Transporters; Probenecid; Rats; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents | 2023 |