uric acid has been researched along with potassium oxonate in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (11.70) | 29.6817 |
| 2010's | 53 (56.38) | 24.3611 |
| 2020's | 30 (31.91) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, CH; Kong, LD; Wang, Y; Yang, C; Zhang, X; Zhu, JX | 1 |
| Kong, LD; Wang, Y; Yang, C; Zhang, X; Zhu, JX | 1 |
| Cheng, CH; Fong, WP; Yu, Z | 1 |
| Kong, LD; Mo, SF; Pan, Y; Zhao, X; Zhu, JX | 1 |
| Awale, S; Kadota, S; Matsumoto, K; Murakami, Y; Nguyen, MT; Shi, L; Tezuka, Y; Tran, QL; Ueda, JY; Zaidi, SF | 1 |
| Chen, GL; Wei, W; Xu, SY | 1 |
| AsokKumar, K; Ravi, TK; Sivashanmugam, T; Somasundaram, A; Subhadradevi, V; Umamaheswari, M | 1 |
| Inoue, H; Kanno, M; Kanno, R; Liu, L; Nakayama, H | 1 |
| Huang, CG; Jiao, BH; Li, WJ; Shang, YJ; Zhang, J; Zhang, JR | 1 |
| Chang, ST; Chu, FH; Liao, JW; Wang, SY; Yang, CW; Zhen, WW | 1 |
| Chen, R; Huang, C; Jiao, B; Liu, X; Shang, Y | 1 |
| Hu, QH; Jiao, RQ; Kong, LD; Lv, YZ; Wang, X | 1 |
| Chang, ST; Chen, CS; Hsu, CA; Huang, CC; Tung, YT; Yang, SC | 1 |
| Bahremand, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mohammadi, H; Mousavizadeh, K; Rahimian, R; Rasouli, MR | 1 |
| Hu, QH; Kong, LD; Wang, Y; Zhang, X | 1 |
| Chun, HK; Chung, DM; Chung, YC; Hwa, KS | 1 |
| Kong, LD; Li, JM; Wang, X; Xie, YC; Zhang, X | 1 |
| de Paula, CA; de Souza Filho, JD; de Souza, MR; Grabe-Guimarães, A; Pereira de Resende, ML; Saúde-Guimarães, DA | 1 |
| Dong, JF; Li, CF; Li, J; Su, DX; Yi, LT | 1 |
| Hong, Y; Kong, LD; Li, Z; Liu, L; Liu, YL; Shi, YW; Wang, CP; Wang, X | 1 |
| Gao, L; Li, L; Lin, H; Liu, X; Lu, W; Niu, Y | 1 |
| Athayde, ML; Bochi, GV; Cabreira, TN; Ferreira, J; Froeder, AL; Fröhlich, JK; Moresco, RN; Oliveira, SM; Rossato, MF; Silva, CR; Trevisan, G | 1 |
| Hu, QH; Ji, H; Ji, J; Miao, MX; Wei, LL; Zhu, JX | 1 |
| Hou, SX; Jeffry, J; Pang, MQ; Zhou, LL; Zhu, WJ | 1 |
| Anderson, S; Wu, XH; Yu, CH; Zhang, CF; Zhang, YW | 1 |
| Ji, Y; Li, J; Liang, J; Liu, M; Liu, T; Su, J; Wei, Y | 1 |
| Han, L; Wang, CZ; Wang, SQ; Wu, XH; Yuan, CS; Zhang, J; Zhang, YW | 1 |
| Ruan, JL; Wang, SQ; Wu, XH; Zhang, J; Zhang, YW | 1 |
| Kong, LD; Liu, YL; Wang, MX; Yang, Y; Zhang, DM | 1 |
| Fang, WR; Feng, YD; Kodithuwakku, ND; Li, YM; Pan, M; Zhang, YY | 1 |
| Anderson, S; He, Y; Hou, PY; Mi, C; Wang, SQ; Wu, XH; Yu, F; Zhang, J; Zhang, YW | 1 |
| Gao, L; Jiang, J; Kong, X; Li, L; Lin, H; Liu, X; Niu, Y; Yang, H; Zhou, Y | 1 |
| Chen, G; Ko, CH; Leung, PC; Li, KK; Tan, ML | 1 |
| Gui, D; Guo, Y; Jiang, Q; Wang, N | 1 |
| Guo, L; Hui, J; Hui, W; Li, L; Qinghua, H; Yongde, C; Yongliang, Y; Zhonglin, Y | 1 |
| Ashizawa, N; Iwanaga, T; Matsumoto, K; Saitoh, K; Taniguchi, T | 1 |
| Chiu, CC; Chuang, HL; Ho, ST; Huang, CC; Lin, CY; Lin, LC; Liu, YL; Tung, YT; Wu, JH | 1 |
| Feng, GH; Gao, LH; Li, L; Liu, HY; Liu, J; Liu, X; Niu, Y | 1 |
| Li, H; Lin, L; Su, G; Wang, Y; Zhao, M | 1 |
| Chen, J; Wang, M; Zhang, N; Zhao, J | 1 |
| Cho, SS; Ki, SH; Park, DH; Yoon, IS | 1 |
| Hsu, CL; Jhang, JJ; Liao, JW; Lin, JH; Lu, CC; Ong, JW; Yen, GC | 1 |
| Hongyan, L; Jie, R; Suling, W; Weina, Z; Yajie, Z | 1 |
| Furuhashi, H; Higashiyama, M; Hokari, R; Komoto, S; Kurihara, C; Maruta, K; Matsuo, H; Miura, S; Nagao, S; Narimatsu, K; Okada, Y; Sato, H; Shirakabe, K; Takajo, T; Tomita, K; Watanabe, C; Yasutake, Y; Yoshikawa, K | 1 |
| Li, ZL; Ma, KL; Tang, DH; Wang, CY; Ye, YS; Zheng, H | 1 |
| Cheng, L; Hu, YJ; Li, LN; Liang, WQ; Liu, PG; Pu, JB; Xu, P; Yang, QQ; Zhang, HJ; Zhang, YQ; Zhou, J | 1 |
| Dong, XY; Li, Z; Li, ZJ; Lu, LF; Wang, CL | 1 |
| Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y | 1 |
| Cheng, P; Fang, J; Jiao, R; Li, T; Li, Y; Li, Z; Liu, X; Ma, Y; Tang, J; Wang, M; Wei, X; Xing, Y | 1 |
| Chen, N; Chu, S; He, F; Li, D; Liao, L; Lu, W; Nong, Z; Su, H; Su, Q; Wang, L; Wei, B; Wei, G; Ya, Q; Zeng, X; Zhao, J | 1 |
| Dohgu, S; Fukae, J; Kataoka, Y; Koga, M; Matsumoto, J; Nakashima, A; Takata, F; Tsuboi, Y; Yamauchi, A | 1 |
| Bai, W; Gao, L; Jiang, J; Li, L; Lin, H; Niu, Y; Tang, Y; Yang, H | 1 |
| Barba, FJ; He, J; Li, S; Lorenzo, JM; Zhan, S; Zhang, R; Zhu, Z | 1 |
| Ma, Y; Rao, Z; Sun, X; Wu, X; Xi, D; Zhang, G | 1 |
| Li, Q; Wang, F; Xing, C; Zhang, Y | 1 |
| Bian, W; Hu, Y; Liu, N; Meng, B; Sun, J; Wang, S; Wang, Y; Xiong, Z; Yang, M; Yang, X; Yin, S; Zeng, L | 1 |
| Choi, CH; Choi, CY; Kang, BY; Kim, JR; Kim, SJ; Kim, YR; Na, CS; Oh, DR | 1 |
| Che, K; Fei, H; Hou, X; Wang, J; Wang, Y; You, W; Zou, Y | 1 |
| Chang, Y; Liang, C; Liang, G; Nie, Y; Xiao, D; Zeng, S; Zhan, S; Zheng, Q; Zheng, X | 1 |
| Li, S; Liu, M; Ma, Q; Qin, N; Wang, C; Yang, F; Yu, M | 1 |
| Chen, JJ; Geng, CA; Hou, B; Huang, XY; Ma, YB; Peng, H; Yan, DX; Yang, TH; Zhang, XM | 1 |
| Kim, DS; Kim, JS; Lee, S; Lee, YS; Son, E; Sung, YY; Yuk, HJ | 1 |
| Dong, Y; Liu, J; Zhao, W; Zhou, H; Zhou, Z | 1 |
| Bhatt, DC; Jindal, DK; Kandav, G | 1 |
| Harada-Shiba, M; Hirata, H; Ogura, M; Ota-Kontani, A; Tsuchiya, Y | 1 |
| Liang, ML; Su, WK; Sun, Y; Wang, HT; Xu, WH; Xue, ZC | 1 |
| Ha, EH; Hu, Q; Li, H; Li, Z; Pang, J; Tian, S; Wang, W; Zhou, M | 1 |
| Abbasi, WM; Ahmad, S; Arshad, MA; Ayaz, S; Bilal, M; Ghauri, AO; Nawaz, A; Rehman, T | 1 |
| Hossain, I; Ishaq, M; Mehmood, A; Nadeem, M; Naveed, M; Raka, RN; Usman, M; Wang, C; Zad, OD; Zhao, L | 1 |
| Gong, M; Han, B; Li, Z; Qiu, Y; Zou, Z | 1 |
| Bao, R; Chen, Q; Liu, L; Liu, M; Wang, D; Wang, T; Wen, S; Yu, H; Zhang, Y | 1 |
| Cao, Y; Chen, Y; Jiang, Y; Li, L; Li, Y; Lin, C; Pang, J; Tian, Y; Wu, T; Yang, Y; Zhao, Z; Zhou, P | 1 |
| Affes, H; Charfi, S; Dhouibi, R; Hammami, S; Jamoussi, K; Ksouda, K; Marekchi, R; Moalla, D; Sahnoun, Z; Salem, MB; Zeghal, KM | 1 |
| Lin, L; Peng, A; Tian, Y; Zhao, K; Zhao, M | 1 |
| Chen, H; Guan, K; Ma, Y; Qi, X; Wang, R | 1 |
| Hou, X; Liu, X; Tian, J; Wang, B; Xiang, L; Xie, B; Zhou, D | 1 |
| Hu, N; Lin, Y; Wang, J; Wang, S; Wang, X; Zhang, B; Zhao, X; Zhou, X | 1 |
| Cao, Y; Chen, Y; Huang, Q; Jiang, Y; Li, L; Li, Y; Luo, J; Pang, J; Wu, T; Zhang, L; Zhao, Z; Zhou, P | 1 |
| Chen, SH; Dong, YJ; He, XL; Li, B; Li, LZ; Lv, GY; Wang, YZ; Xu, WF; Yu, QX; Zheng, X; Zhou, C; Zhu, LJ | 1 |
| Fang, J; Guo, Y; Ma, Q; Qin, N; Shi, W; Wang, C; Wang, L; Xu, G; Yang, F; Yu, X | 1 |
| Cai, J; Chen, J; Gao, C; Jiang, L; Liu, Y; Su, Z; Wei, L; Wu, X; Wu, Y; Xiao, S; Xu, L | 1 |
| Kim, DS; Sung, YY | 1 |
| Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q | 1 |
| Chen, Y; Liu, T; Yang, Z; Yuan, F; Zhang, L; Zhang, S; Zhou, X; Zhuang, J | 1 |
| Guo, S; Hu, SS; Lu, PF; Meng, FH; Wang, ZR; Zhang, TJ; Zhang, X; Zhang, Y; Zhang, ZH | 1 |
| Hu, BY; Luo, XD; Ma, DY; Xiang, ML; Zhao, LX; Zhao, YL | 1 |
| Abukhalil, MH; Ahmeda, AF; Alotaibi, MF; ALRashdi, BM; Alruhaimi, RS; Alzoghaibi, MA; Arab, HH; Azab, MS; Elgebaly, HA; Germoush, MO; Kamel, EM; Mahmoud, AM; Qarmush, MM | 1 |
| Chen, C; Chen, FA; Chen, HC; Chiu, PY; Li, YL; Wang, CC | 1 |
| Huang, Q; Jiang, Y; Li, Y; Liao, H; Lin, C; Luo, J; Pang, J; Wu, T; Yan, C; Yang, Y; Zhang, L; Zhang, W; Zheng, Q | 1 |
| Cai, Y; Cai, Z; Chen, T; Huang, X; Mi, X; Shui, G; Wang, F | 1 |
| Du, L; Shen, Y; Su, E; Wei, D; Xie, D; Xie, J | 1 |
| Chan, ST; Chiang, CF; Chien, CY; Chien, YJ; Hsu, CL; Hu, WC; Lin, YH; Wu, HF | 1 |
| Hu, Q; Luo, J; Peng, X; Wu, C; Zhang, G | 1 |
| Huang, XY; Li, W; Liu, HB; Liu, T; Luo, T; Luo, Y; Wu, Y; Yang, M; Zhang, YL | 1 |
1 trial(s) available for uric acid and potassium oxonate
| Article | Year |
|---|---|
Simiao pill inhibits epithelial mesenchymal transition in a mouse model of chronic hyperuricemic nephropathy by inhibiting NLRP3 inflammasome activation.
Topics: Actins; Animals; Cadherins; Caspases; Disease Models, Animal; Epithelial-Mesenchymal Transition; Febuxostat; Fibronectins; Hyperuricemia; Inflammasomes; Interleukin-18; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Renal Insufficiency, Chronic; Uric Acid; Vimentin | 2022 |
93 other study(ies) available for uric acid and potassium oxonate
| Article | Year |
|---|---|
Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.
Topics: Allopurinol; Animals; Antioxidants; Biflavonoids; Catechin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Proanthocyanidins; Seeds; Time Factors; Urate Oxidase; Uric Acid; Vitis; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Topics: Animals; Flavonoids; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Plant Leaves; Quercetin; Rutin; Thuja; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Creatinine; Enzyme Inhibitors; Flavonoids; Hyperuricemia; In Vitro Techniques; Kidney; Kinetics; Male; Microvilli; Oxonic Acid; Rats; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2006 |
Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Topics: Administration, Oral; Allopurinol; Animals; Cinnamomum aromaticum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperuricemia; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Bark; Plant Oils; Time Factors; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2006 |
Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats.
Topics: Administration, Oral; Allopurinol; Animals; Chrysanthemum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Esters; Flavones; Hyperuricemia; Inhibitory Concentration 50; Injections, Intraperitoneal; Liver; Male; Oxonic Acid; Quinic Acid; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2005 |
Effect and mechanism of total saponin of Dioscorea on animal experimental hyperuricemia.
Topics: Animals; Dioscorea; Disease Models, Animal; Hyperuricemia; Injections, Intraperitoneal; Liver; Male; Mice; Oxonic Acid; Rats; Rats, Wistar; Saponins; Uric Acid; Xanthine Oxidase; Yeasts | 2006 |
Xanthine oxidase inhibitory activity of some Indian medical plants.
Topics: Animals; Female; Hyperuricemia; India; Lethal Dose 50; Magnoliopsida; Male; Medicine, Traditional; Mice; Oxonic Acid; Plant Extracts; Plant Leaves; Plants, Medicinal; Uric Acid; Xanthine Oxidase | 2007 |
The endogenous danger signal uric Acid augments contact hypersensitivity responses in mice.
Topics: Animals; B7-2 Antigen; CD40 Antigens; Chlorobenzenes; Dendritic Cells; Dermatitis, Contact; Drug Synergism; Ear, External; Edema; Immunity, Cellular; Injections, Subcutaneous; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Oxonic Acid; Signal Transduction; T-Lymphocyte Subsets; Uric Acid | 2007 |
Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice.
Topics: Animals; Glycosides; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Plant Roots; Scrophularia; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2008 |
Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice.
Topics: Acrolein; Administration, Oral; Allopurinol; Animals; Cinnamomum; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Inhibitory Concentration 50; Male; Mice; Mice, Inbred ICR; Oils, Volatile; Oxonic Acid; Plant Extracts; Plant Leaves; Plant Oils; Taiwan; Uric Acid; Xanthine Oxidase | 2008 |
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Benzofurans; Depsides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hyperuricemia; Inflammation; Male; Molecular Conformation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxonic Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Uric Acid; Xanthine Oxidase | 2008 |
Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice.
Topics: Allopurinol; Animals; Biological Transport; Gout; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred Strains; Organic Anion Transporters; Oxonic Acid; Reverse Transcriptase Polymerase Chain Reaction; Uric Acid | 2010 |
Phytochemicals from Acacia confusa heartwood extracts reduce serum uric acid levels in oxonate-induced mice: their potential use as xanthine oxidase inhibitors.
Topics: Acacia; Animals; Drug Discovery; Enzyme Inhibitors; Flavonoids; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Urate Oxidase; Uric Acid; Wood; Xanthine Oxidase | 2010 |
Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Colitis; Dietary Supplements; Drug Synergism; Enzyme Inhibitors; Inflammation Mediators; Inflammatory Bowel Diseases; Inosine Monophosphate; Lipid Peroxidation; Macrophages; Male; Neutrophil Infiltration; Oxonic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Urate Oxidase; Uric Acid | 2010 |
[Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice].
Topics: Animals; Blood Urea Nitrogen; Carrier Proteins; Creatinine; Glucose Transport Proteins, Facilitative; Hyperuricemia; Kidney; Male; Membrane Proteins; Mice; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Protective Agents; Random Allocation; RNA, Messenger; Solute Carrier Family 22 Member 5; Symporters; Uric Acid; Uromodulin; Xanthones | 2010 |
Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice.
Topics: Allopurinol; Animals; Anthocyanins; Disease Models, Animal; Hyperuricemia; Ipomoea batatas; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Uric Acid | 2011 |
Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice.
Topics: Aesculus; Animals; Coumarins; Drugs, Chinese Herbal; Gene Expression Regulation; Hyperuricemia; Kidney; Male; Membrane Transport Proteins; Mice; Oxonic Acid; Uric Acid | 2011 |
Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Asteraceae; Ethanol; Flavonoids; Hyperuricemia; Inflammation; Liver; Male; Mice; Oxonic Acid; Phytotherapy; Plant Components, Aerial; Plant Extracts; Solvents; Uric Acid; Xanthine Oxidase | 2012 |
Hypouricemic effect of the methanol extract from Prunus mume fruit in mice.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Hyperuricemia; Liver; Male; Medicine, East Asian Traditional; Methanol; Mice; Oxonic Acid; Plant Extracts; Prunus; Uric Acid; Xanthine Oxidase | 2012 |
Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Urea Nitrogen; Carrier Proteins; Creatinine; Disaccharides; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Glucosides; Gout Suppressants; Hyperuricemia; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Resveratrol; Solute Carrier Family 22 Member 5; Stilbenes; Symporters; Uric Acid | 2012 |
Reducing effect of mangiferin on serum uric acid levels in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Mice, Inbred Strains; Oxonic Acid; Time Factors; Toxicity Tests, Acute; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthones | 2012 |
The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Biomarkers, Pharmacological; Disease Models, Animal; Edema; Hyperalgesia; Hyperuricemia; Jatropha; Male; Motor Activity; Neutrophil Infiltration; Oxonic Acid; Peroxidase; Phytotherapy; Plant Extracts; Rats; Stomach Ulcer; Uric Acid; Xanthine Oxidase | 2013 |
Fructus Gardenia Extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3.
Topics: Animals; Blood Urea Nitrogen; Gardenia; Gene Expression Regulation; Humans; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Renal Insufficiency; Uric Acid | 2013 |
Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate.
Topics: Animals; Base Sequence; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; DNA Primers; Hypertension; Iridoid Glycosides; Kidney Diseases; Male; Nitric Oxide Synthase; Oxonic Acid; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rubiaceae; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Uric Acid; Yeasts | 2014 |
Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
Topics: Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Gout; Gout Suppressants; Hyperuricemia; Kidney; Mice; Organic Anion Transporters; Oxonic Acid; Phytotherapy; Plant Roots; Rhizome; Saponins; Smilax; Uric Acid | 2014 |
Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
Topics: Animals; Creatinine; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Hypertension; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Uric Acid; Xanthine Oxidase | 2014 |
Effects of Smilaxchinoside A and Smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Glucose Transport Proteins, Facilitative; Glycosides; Hyperuricemia; Kidney; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Plant Roots; Saponins; Smilax; Steroids; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Glucose Transport Proteins, Facilitative; Hyperuricemia; Male; Medicine, Chinese Traditional; Mice; Organic Anion Transporters; Oxonic Acid; Plant Roots; Rhizome; Saponins; Smilax; Uric Acid | 2014 |
Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
Topics: Animals; Aporphines; Carrier Proteins; Cell Line; Humans; Hyperuricemia; Inflammasomes; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestines; Kidney; Male; Mice; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Organic Anion Transporters; Oxonic Acid; Signal Transduction; Toll-Like Receptor 4; Uric Acid | 2015 |
The molecular insight into the antihyperuricemic and renoprotective effect of Shuang Qi gout capsule in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Urea Nitrogen; Capsules; Carrier Proteins; Creatinine; Drugs, Chinese Herbal; Gout; Gout Suppressants; Hyperuricemia; Kidney; Male; Membrane Proteins; Mice, Inbred ICR; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Protective Agents; Solute Carrier Family 22 Member 5; Symporters; Uric Acid | 2015 |
Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice.
Topics: Allopurinol; Animals; Creatinine; Disease Models, Animal; Drug Synergism; Glucose Transport Proteins, Facilitative; Glycosides; Gout Suppressants; Hyperuricemia; Male; Mice; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Saponins; Smilax; Uric Acid; Xanthine Oxidase | 2015 |
Mangiferin Inhibits Renal Urate Reabsorption by Modulating Urate Transporters in Experimental Hyperuricemia.
Topics: Animals; Anion Transport Proteins; Carrier Proteins; Cytoskeletal Proteins; Hyperuricemia; Kidney; Male; Mice; Monosaccharide Transport Proteins; Oxonic Acid; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Xanthones | 2015 |
Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice.
Topics: Animals; Gout Suppressants; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Polyphenols; Tea; Uric Acid; Xanthine Oxidase | 2015 |
Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate.
Topics: Adenine; Administration, Oral; Animals; Benzbromarone; Creatinine; Drug Synergism; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Plant Exudates; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2015 |
Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3.
Topics: Animals; Elaeagnaceae; Hyperuricemia; Ion Transport; Kidney; Male; Membrane Proteins; Mice; Molecular Structure; Oleanolic Acid; Oxonic Acid; Protective Agents; Proteinuria; Uric Acid | 2016 |
Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Inosine; Male; Nitriles; Oxonic Acid; Probenecid; Pyridines; Rats; Rats, Wistar; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Dehydrogenase | 2016 |
Antioxidative phytochemicals from Rhododendron oldhamii Maxim. leaf extracts reduce serum uric acid levels in potassium oxonate-induced hyperuricemic mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Gout Suppressants; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Rhododendron; Uric Acid | 2015 |
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity.
Topics: Administration, Oral; Animals; Biomarkers; Biotransformation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Kinetics; Mice; Molecular Structure; Oxonic Acid; Structure-Activity Relationship; Uric Acid; Xanthenes; Xanthine Oxidase; Xanthones | 2016 |
Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor.
Topics: Animals; Body Weight; Carbolines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Furans; Hyperuricemia; Male; Molecular Docking Simulation; Oxonic Acid; Rats, Sprague-Dawley; Soy Foods; Uric Acid; Xanthine Oxidase | 2016 |
Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice.
Topics: Animals; Carrier Proteins; Flavonols; Hyperuricemia; Inflammasomes; Inflammation; Janus Kinase 2; Kidney; Male; Membrane Transport Proteins; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Oxonic Acid; Podocytes; Signal Transduction; STAT3 Transcription Factor; Thioredoxins; Uric Acid | 2016 |
Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Flowers; Gout Suppressants; Hamamelidaceae; Hyperuricemia; Liver; Male; Mice, Inbred ICR; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Plants, Medicinal; Solvents; Uric Acid; Xanthine Oxidase | 2016 |
Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo.
Topics: Animals; Humans; Hyperuricemia; Lamiaceae; Liver; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Streptozocin; THP-1 Cells; Uric Acid; Xanthine Oxidase | 2016 |
Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Flavanones; Gout Suppressants; Hyperuricemia; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Treatment Outcome; Uric Acid | 2016 |
Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Disease Models, Animal; Gastrointestinal Diseases; Humans; Ileum; Indomethacin; Inosine Monophosphate; Lipid Peroxidation; Male; Mice, Inbred C57BL; Oxonic Acid; Uric Acid | 2017 |
Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis).
Topics: Acute Disease; Allopurinol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Humans; Hyperuricemia; Injections, Intraperitoneal; Liver; Oxonic Acid; RNA, Messenger; Tupaia; Urate Oxidase; Uric Acid; Xanthine Dehydrogenase | 2017 |
Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Chromatography, High Pressure Liquid; Disease Models, Animal; Edema; Gnaphalium; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Tandem Mass Spectrometry; Uric Acid; Xanthine Oxidase | 2017 |
Hypouricemic and nephroprotective effects of total flavonoids from the residue of supercritical CO2 extraction of Humulus lupulus in potassium oxonate-induced mice.
Topics: Animals; Carbon Dioxide; Chromatography, Supercritical Fluid; Flavonoids; Humulus; Hyperuricemia; Inhibitory Concentration 50; Kidney; Male; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2017 |
Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Topics: Adenine; Animals; Biomarkers; Creatinine; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Transport Proteins, Facilitative; HCT116 Cells; Humans; Hyperuricemia; Intestinal Elimination; Intestinal Mucosa; Intestines; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Renal Elimination; Spirostans; Time Factors; Uric Acid; Uricosuric Agents | 2018 |
A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice.
Topics: Allopurinol; Animals; Antibodies, Monoclonal; Antibody Affinity; Antioxidants; Creatinine; Cross Reactions; Female; Immune Sera; Immunization; Immunoglobulin G; Inflammation; Kidney; Liver; Malondialdehyde; Mice; Mice, Inbred BALB C; Oxonic Acid; Protective Agents; Spleen; Superoxide Dismutase; Th1 Cells; Th2 Cells; Urea; Uric Acid; Xanthine Oxidase | 2018 |
Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ants; Hyperuricemia; Kidney; Liver; Male; Oxonic Acid; Protective Agents; Rats; Uric Acid | 2018 |
Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Hyperuricemia; Male; Mental Disorders; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Oxonic Acid; Parkinson Disease, Secondary; Rotarod Performance Test; Tyrosine 3-Monooxygenase; Uric Acid | 2019 |
Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
Topics: Administration, Oral; Animals; Aorta; C-Reactive Protein; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Hyperuricemia; Intercellular Adhesion Molecule-1; Mangifera; Nitric Oxide; Nitric Oxide Synthase Type III; Oxonic Acid; Phytotherapy; Plant Leaves; Rats, Sprague-Dawley; Systole; Uric Acid; Xanthones | 2018 |
Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice.
Topics: Animals; Creatinine; Disease Models, Animal; Fruit; Gene Expression Regulation; Hyperuricemia; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Rosaceae; Uric Acid; Xanthine Oxidase | 2018 |
Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies.
Topics: Animals; Antiporters; Cell Line; Humans; Hyperuricemia; Hypoglycemic Agents; Kidney; Liver; Male; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Oxonic Acid; Rats, Wistar; Recombinant Proteins; Tissue Distribution; Uric Acid | 2019 |
A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.
Topics: Allopurinol; Animals; Anserine; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Hyperuricemia; Larva; Oxonic Acid; Uric Acid; Xanthine; Zebrafish | 2019 |
New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats.
Topics: Animals; Humans; Hyperuricemia; Liver; Male; Oryza; Oxonic Acid; Peptides; Plant Extracts; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2019 |
Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.
Topics: Animals; Creatinine; Down-Regulation; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Humans; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred ICR; Organic Anion Transporters; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2019 |
Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice.
Topics: Animals; Creatinine; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Male; Mice; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Protective Agents; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2019 |
Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.
Topics: Animals; Antioxidants; Arthritis, Gouty; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Flavonols; Glycosides; Gout; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice, Inbred BALB C; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Smilax; Tandem Mass Spectrometry; Uric Acid | 2019 |
Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Discriminant Analysis; Hyperuricemia; Least-Squares Analysis; Lipid Metabolism; Lipids; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Multivariate Analysis; Oxonic Acid; Principal Component Analysis; Rats, Sprague-Dawley; Uric Acid | 2019 |
Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.
Topics: Anacardiaceae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chalcone; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Flavanones; Hyperuricemia; Inflammation; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oxonic Acid; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2019 |
Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.
Topics: Alpinia; Animals; China; Gout; Humans; Hyperuricemia; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Rats; Republic of Korea; Uric Acid; Xanthine Oxidase | 2019 |
MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Topics: Animals; Base Sequence; Case-Control Studies; Chemokine CCL2; Disease Models, Animal; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Humans; Hyperuricemia; Hypoxanthine; Inflammation; Interleukin-1beta; Kidney Cortex; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Oligonucleotide Array Sequence Analysis; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Renal Reabsorption; Signal Transduction; Uric Acid | 2019 |
Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis.
Topics: Administration, Oral; Allopurinol; Animals; Chemical Precipitation; Chitosan; Disease Models, Animal; Drug Delivery Systems; Kidney; Magnetite Nanoparticles; Mice; Nanoparticles; Nephrolithiasis; Oxonic Acid; Uric Acid | 2019 |
Comprehensive analysis of mechanism underlying hypouricemic effect of glucosyl hesperidin.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Glucose Transport Proteins, Facilitative; Glucosides; Hesperidin; Hyperuricemia; Intestine, Small; Kidney; Liver; Male; Mice, Inbred C57BL; Organic Anion Transporters; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2020 |
Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice.
Topics: Animals; Creatinine; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transporters; Orthosiphon; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2020 |
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Topics: Animals; Benzimidazoles; Benzoxazoles; Cell Line; Disease Models, Animal; Gout; Humans; Hyperuricemia; Interleukin-1beta; Liver; Mice; Monocytes; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Rats; Structure-Activity Relationship; Synovial Membrane; Uric Acid; Xanthine Oxidase | 2020 |
Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat's model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Drug Development; Gout Suppressants; Hyperuricemia; Male; Oxonic Acid; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Uric Acid | 2020 |
Uricostatic and uricosuric effect of grapefruit juice in potassium oxonate-induced hyperuricemic mice.
Topics: Animals; Citrus paradisi; Hyperuricemia; Mice; Oxonic Acid; Uric Acid | 2020 |
NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Glucosides; Humans; Hyperuricemia; Kidney; Male; Metabolomics; Oxonic Acid; Rats; Rats, Sprague-Dawley; Stilbenes; Uric Acid | 2020 |
The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Chromatography, High Pressure Liquid; Creatinine; Disease Models, Animal; Glucose Transport Proteins, Facilitative; Hyperuricemia; Kidney; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Sodium-Phosphate Cotransporter Proteins, Type I; Time Factors; Uric Acid | 2020 |
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Topics: Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibitors; Flavanones; Glucose Transport Proteins, Facilitative; HEK293 Cells; Humans; Hyperuricemia; Kidney; Liver; Male; Mice; Molecular Docking Simulation; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2021 |
Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance.
Topics: Animals; Antioxidants; Biomarkers; Chronic Disease; Creatinine; Disease Models, Animal; Hyperuricemia; Kidney; Lipid Peroxidation; Liver; Male; Oxonic Acid; Rats, Wistar; Urea; Uric Acid | 2021 |
Xanthine oxidase inhibitory activity and antihyperuricemic effect of Moringa oleifera Lam. leaf hydrolysate rich in phenolics and peptides.
Topics: Animals; Creatinine; Disease Models, Animal; Flavonoids; Gout Suppressants; Hyperuricemia; Malondialdehyde; Moringa oleifera; Organic Anion Transporters; Oxonic Acid; Peptides; Phenols; Plant Extracts; Plant Leaves; Rats; Triglycerides; Uric Acid; Xanthine Oxidase | 2021 |
Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats.
Topics: Adenosine Deaminase; Animals; Creatinine; Humans; Hyperuricemia; Kidney; Liver; Male; Oxonic Acid; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Uric Acid; Whey; Whey Proteins; Xanthine Oxidase | 2021 |
Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Creatinine; Cytokines; Disease Models, Animal; Disulfiram; Humans; Mice; Oxonic Acid; Pyroptosis; Uric Acid | 2022 |
Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.
Topics: Animals; Blood Urea Nitrogen; Chlorogenic Acid; Creatinine; Dietary Supplements; Gastrointestinal Microbiome; Homeostasis; Hyperuricemia; Hypoxanthine; Inflammation; Interleukin-1beta; Intestines; Kidney; Lipopolysaccharides; Male; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Oxonic Acid; Signal Transduction; Toll-Like Receptor 4; Uric Acid; Xanthine Oxidase | 2021 |
Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway.
Topics: Animals; Apigenin; beta Catenin; Creatinine; Dose-Response Relationship, Drug; Fibrosis; Glucose Transport Proteins, Facilitative; HEK293 Cells; Humans; Hyperuricemia; Kidney Diseases; Male; Mice; Nephritis; Organic Anion Transporters; Oxonic Acid; Uric Acid; Wnt Signaling Pathway | 2021 |
Effects of Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Fructose and Potassium Oxonate.
Topics: Adenosine Triphosphate; Animals; Dendrobium; Fructose; Hyperuricemia; Kidney; Oxonic Acid; Plant Extracts; Plant Leaves; Rats; Uric Acid; Xanthine Oxidase | 2022 |
Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat.
Topics: Animals; Creatinine; Hyperuricemia; Lipid Metabolism; Lipidomics; Oxonic Acid; Psyllium; Rats, Sprague-Dawley; Triglycerides; Tumor Necrosis Factor-alpha; Uric Acid | 2021 |
Topics: Acute Kidney Injury; Animals; Animals, Outbred Strains; Carrier Proteins; Cytokines; Dietary Supplements; Fatty Acids; Hyperuricemia; Hypoxanthine; Kelch-Like ECH-Associated Protein 1; Kidney; Lythraceae; Male; Mice; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Organic Anion Transporters; Oxidative Stress; Oxonic Acid; Plant Oils; Reactive Oxygen Species; Seeds; Signal Transduction; Thioredoxins; Uric Acid | 2021 |
Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats.
Topics: Animals; Egg Shell; Humans; Hyperuricemia; Inflammation; Injections; Kidney; Kidney Function Tests; Male; Oocytes; Organic Anion Transporters; Oxonic Acid; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase; Xenopus | 2021 |
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Berberine; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Cytokines; Disease Models, Animal; Glucose Transport Proteins, Facilitative; Hyperuricemia; Hypoxanthine; Janus Kinase 2; Kidney Diseases; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Protective Agents; Signal Transduction; STAT3 Transcription Factor; Uric Acid; Xanthine Oxidase | 2021 |
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Topics: Animals; Antioxidants; Hyperuricemia; Hypoxanthine; Inflammation; Kidney; Male; Mice; Mice, Inbred ICR; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Signal Transduction; Transcription Factor RelA; Uric Acid; Xanthine Oxidase; Xanthophylls | 2021 |
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
Topics: Animals; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hyperuricemia; Ligands; Models, Molecular; Molecular Structure; Oxonic Acid; Rats; Structure-Activity Relationship; Triazoles; Uric Acid; Xanthine Oxidase | 2022 |
Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro.
Topics: Alstonia; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Uric Acid | 2022 |
A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
Topics: Animals; Catalase; Creatinine; Cytokines; Flavonoids; Hyperuricemia; Inflammation; Kidney; Molecular Docking Simulation; Oxonic Acid; Plant Extracts; Rats; Superoxide Dismutase; Urea; Uric Acid; Xanthine Oxidase | 2022 |
Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia.
Topics: Animals; Antioxidants; Cornus; Gout; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2022 |
Assessment of the influence on left ventricle by potassium oxonate and hypoxanthine-induced chronic hyperuricemia.
Topics: Animals; Heart Ventricles; Hyperuricemia; Hypoxanthines; Mice; Uric Acid | 2023 |
Anti-Hyperuricemic, Nephroprotective, and Gut Microbiota Regulative Effects of Separated Hydrolysate of α-Lactalbumin on Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.
Topics: Animals; Gastrointestinal Microbiome; Hyperuricemia; Hypoxanthines; Inflammation; Kidney; Lactalbumin; Mice; Oxonic Acid; Transcription Factors; Uric Acid | 2023 |
Supplementation of
Topics: Animals; Dietary Supplements; Hyperuricemia; Lactobacillus plantarum; Male; Potassium; Rats; Rats, Sprague-Dawley; Uric Acid | 2022 |
Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation.
Topics: Animals; Carrier Proteins; Fish Proteins; Hyperuricemia; Inflammation; Intestinal Diseases; Kidney; Peptides; Rats; Uric Acid | 2023 |
Dispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models.
Topics: Animals; Hyperuricemia; Interleukin-17; Kidney; Molecular Docking Simulation; Rats; Uric Acid; Xanthine Oxidase | 2023 |