uric acid has been researched along with oxonic acid in 185 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (25.41) | 18.7374 |
| 1990's | 7 (3.78) | 18.2507 |
| 2000's | 26 (14.05) | 29.6817 |
| 2010's | 71 (38.38) | 24.3611 |
| 2020's | 34 (18.38) | 2.80 |
| Authors | Studies |
|---|---|
| Bertuzzi, F; Poje, M; Poje, N; Rocić, B; Vucić-Lovrencić, M | 1 |
| Cheleski, J; da Silva, AB; Montanari, CA; Nonato, MC; Pinheiro, MP; Rocha, JR; Wiggers, HJ | 1 |
| Conger, JD; Falk, SA | 1 |
| Musil, J | 1 |
| Nera, EA; Stavric, B | 1 |
| Combs, AB; Hsu, TF; Newburger, J | 2 |
| Munday, KA; Taylor, TG; Turner, MR; Winocour, PD | 2 |
| Mangoff, SC; Milner, JA | 1 |
| Milner, JA; Perkins, EG | 1 |
| de Médicis, R; Lussier, A; Mathon, G | 1 |
| de Medicis, R; Lussier, A; Marquis, L; Menard, H | 1 |
| Chartrand, A; Johnson, WJ | 1 |
| Miyoshi, N | 2 |
| Förster, H; Hartmann, H | 1 |
| Förster, H; Hoos, I | 1 |
| Bluestone, R; Klinenberg, JR; Waisman, J | 2 |
| Deetjen, P; Greger, R; Knox, FG; Lang, F | 1 |
| Förster, H; Hartmann, H; Hoos, I | 1 |
| Abramson, RG; Briggs, JP; Levitt, MF | 1 |
| Greenberg, BP; Wexler, BC | 1 |
| Robinson, RR; Spencer, HW; Yarger, WE | 1 |
| De Rougemont, D; Henchoz, M; Roch-Ramel, F | 1 |
| Munday, KA; Taylor, TG; Tuner, MR; Winocour, PD | 1 |
| Clayman, S; Gadd, RE; Hébert, D; Stavric, B | 1 |
| Bluestone, R; Klinenberg, JR; Mwasi, LM; Waisman, J | 1 |
| Chartrand, A; Clayman, S; Gadd, RE; Johnson, WJ; Stavric, B | 1 |
| Shinosaki, T; Yonetani, Y | 1 |
| Halliwell, B; Kaur, H | 1 |
| Barrera, CM; Dohanich, GP; Dunlap, WP; Hunter, RE | 1 |
| MacDougall, ML; Wiegmann, TB | 1 |
| Barrera, CM; Dunlap, WP; Hunter, RE | 1 |
| Iwaki, K; Ogawa, Y; Yonetani, Y | 1 |
| Shimada, H; Sugino, H | 1 |
| Abramson, RG; Lipkowitz, MS | 1 |
| Holländer, E | 1 |
| Kagoshima, M; Katagiri, S; Sugino, H | 1 |
| Iwaki, K; Yonetani, Y | 1 |
| Hropot, M; Klaus, E; Muschaweck, R | 1 |
| Hirai, A; Kumagai, A | 1 |
| Hropot, M; Lang, HJ; Muschaweck, R; Sörgel, F; von Kerékjártó, B | 1 |
| Bluestone, R; Chang, YH | 1 |
| Braaten, JT; Scott, FW; Siddiqui, Y; Stavric, B; Trick, KD | 1 |
| Wexler, BC | 1 |
| Ishii, M; Iwaki, K; Yonetani, Y | 1 |
| Brown, EA; Finkelstein, FO; Hayslett, JP; Kliger, AS | 1 |
| Bigalke, KH; Hering, F; Lutzeyer, W | 1 |
| Arezzini, L; Cinci, G; Marinello, E; Pagani, R; Pandolfi, ML; Pizzichini, M; Tabucchi, A; Terzuoli, L | 1 |
| Dan, T; Onoma, M; Onuma, E; Ozawa, K; Yoneya, T | 1 |
| Abramson, RG; Cohen, BE; Leal-Pinto, E | 1 |
| Church, WH; Rappolt, G | 1 |
| Arezzini, L; Cinci, G; Guerranti, R; Marinello, E; Pizzichini, M; Porcelli, B; Terzuoli, L | 1 |
| Gordon, KL; Hughes, J; Jefferson, JA; Johnson, RJ; Kang, DH; Kim, YG; Kivlighn, SD; Lan, HY; Mazzali, M; Suga, S | 1 |
| Cheng, CH; Kong, L; Li, J; Wen, Y; Zhou, J | 1 |
| Chen, Q; Feng, L; Gordon, KL; Han, L; Johnson, RJ; Kanellis, J; Kang, DH; Lan, HY; Mazzali, M; Nakagawa, T; Watanabe, S; Xia, YY | 1 |
| Avila-Casado, C; Franco, M; Herrera-Acosta, J; Johnson, RJ; Nakagawa, T; Rodríguez-Iturbe, B; Sánchez-Lozada, LG; Santamaría, J; Soto, V; Tapia, E | 1 |
| Hooper, DC; Kean, RB; Koprowski, H; Mikheeva, T; Scott, GS; Spitsin, SV | 1 |
| BRANDENBERGER, H | 1 |
| CANELLAKIS, ES; COHEN, PP | 1 |
| Bonneté, F; Castro, B; Colloc'h, N; El-Hajji, M; Monard, G; Mornon, JP; Prangé, T; Retailleau, P; Vivarès, D | 1 |
| Cheng, CH; Kong, LD; Wang, Y; Yang, C; Zhang, X; Zhu, JX | 1 |
| Kong, LD; Wang, Y; Yang, C; Zhang, X; Zhu, JX | 1 |
| Nishioka, N; Tsuji, T; Yoshizumi, K | 1 |
| Cheng, CH; Fong, WP; Yu, Z | 1 |
| Kong, LD; Mo, SF; Pan, Y; Zhao, X; Zhu, JX | 1 |
| Awale, S; Kadota, S; Matsumoto, K; Murakami, Y; Nguyen, MT; Shi, L; Tezuka, Y; Tran, QL; Ueda, JY; Zaidi, SF | 1 |
| Herrera-Acosta, J; Johnson, RJ; Kang, DH; Mazzali, M; Nakagawa, T; Sánchez-Lozada, LG | 1 |
| Chen, GL; Wei, W; Xu, SY | 1 |
| AsokKumar, K; Ravi, TK; Sivashanmugam, T; Somasundaram, A; Subhadradevi, V; Umamaheswari, M | 1 |
| Chintala, S; Gobe, GG; Goligorsky, MS; Patschan, D; Patschan, S | 1 |
| Inoue, H; Kanno, M; Kanno, R; Liu, L; Nakayama, H | 1 |
| Avila-Casado, C; Franco, M; Johnson, RJ; Sánchez-Lozada, LG; Soto, V; Tapia, E; Zhao, L | 1 |
| Huang, CG; Jiao, BH; Li, WJ; Shang, YJ; Zhang, J; Zhang, JR | 1 |
| Eräranta, A; Kööbi, P; Kurra, V; Lakkisto, P; Mustonen, JT; Niemelä, OJ; Pörsti, IH; Tahvanainen, AM; Tikkanen, I; Vehmas, TI | 1 |
| Chang, ST; Chu, FH; Liao, JW; Wang, SY; Yang, CW; Zhen, WW | 1 |
| Chen, R; Huang, C; Jiao, B; Liu, X; Shang, Y | 1 |
| Chen, K; Cui, WY; Liu, GS; Long, CL; Pan, ZY; Qin, XC; Wang, H; Zhang, YF | 1 |
| Eräranta, A; Jolma, P; Kalliovalkama, J; Kurra, V; Moilanen, E; Mustonen, J; Myllymäki, J; Niemelä, O; Pörsti, I; Riutta, A; Tahvanainen, A; Vehmas, TI | 1 |
| Chiou, HY; Lai, SH; Lo, HC; Wang, YH; Yang, Y | 1 |
| Hu, QH; Jiao, RQ; Kong, LD; Lv, YZ; Wang, X | 1 |
| Chang, ST; Chen, CS; Hsu, CA; Huang, CC; Tung, YT; Yang, SC | 1 |
| Bahremand, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mohammadi, H; Mousavizadeh, K; Rahimian, R; Rasouli, MR | 1 |
| Chernichovski, T; Engel, A; Grupper, A; Hillel, O; Schwartz, D; Schwartz, IF | 1 |
| Hu, QH; Kong, LD; Wang, Y; Zhang, X | 1 |
| Chun, HK; Chung, DM; Chung, YC; Hwa, KS | 1 |
| Kong, LD; Li, JM; Wang, X; Xie, YC; Zhang, X | 1 |
| de Paula, CA; de Souza Filho, JD; de Souza, MR; Grabe-Guimarães, A; Pereira de Resende, ML; Saúde-Guimarães, DA | 1 |
| Dong, JF; Li, CF; Li, J; Su, DX; Yi, LT | 1 |
| Hong, Y; Kong, LD; Li, Z; Liu, L; Liu, YL; Shi, YW; Wang, CP; Wang, X | 1 |
| Gao, L; Li, L; Lin, H; Liu, X; Lu, W; Niu, Y | 1 |
| Fu, HW; Hou, CW; Hung, HF; Jeng, KC; Lee, YC | 1 |
| Shtrygol, S; Tovchiga, O | 1 |
| Athayde, ML; Bochi, GV; Cabreira, TN; Ferreira, J; Froeder, AL; Fröhlich, JK; Moresco, RN; Oliveira, SM; Rossato, MF; Silva, CR; Trevisan, G | 1 |
| Cristóbal, M; Cruz-Robles, D; García-Arroyo, FE; Ishimoto, T; Johnson, RJ; Lanaspa, MA; Madero, M; Monroy-Sánchez, F; Pacheco, U; Roncal-Jiménez, CA; Sánchez-Lozada, LG; Soto, V; Tapia, E | 1 |
| Dankers, AC; Dijkman, HB; Hoenderop, JG; Masereeuw, R; Mutsaers, HA; Russel, FG; Sweep, FC; van den Heuvel, LP | 1 |
| Hu, QH; Ji, H; Ji, J; Miao, MX; Wei, LL; Zhu, JX | 1 |
| Hou, SX; Jeffry, J; Pang, MQ; Zhou, LL; Zhu, WJ | 1 |
| Anderson, S; Wu, XH; Yu, CH; Zhang, CF; Zhang, YW | 1 |
| Chen, JW; Guo, J; Jiang, JM; Li, C; Xue, ZY; Zhou, LY; Zhou, Y | 1 |
| Ji, Y; Li, J; Liang, J; Liu, M; Liu, T; Su, J; Wei, Y | 1 |
| Dong, Y; Lin, L; Su, G; Sun-Waterhouse, D; Wang, X; Zhao, M; Zhu, D | 1 |
| Han, L; Wang, CZ; Wang, SQ; Wu, XH; Yuan, CS; Zhang, J; Zhang, YW | 1 |
| Ruan, JL; Wang, SQ; Wu, XH; Zhang, J; Zhang, YW | 1 |
| Kong, LD; Liu, YL; Wang, MX; Yang, Y; Zhang, DM | 1 |
| de Paula, CA; de Sá Pereira, BM; de Souza, MR; Ferrari, FC; Lemos Lima, Rde C; Saúde-Guimarães, DA | 1 |
| Fang, WR; Feng, YD; Kodithuwakku, ND; Li, YM; Pan, M; Zhang, YY | 1 |
| Eräranta, A; Jokihaara, J; Kurra, V; Mustonen, J; Niemelä, O; Pirttiniemi, P; Pörsti, I; Ruskoaho, H; Tokola, H; Vehmas, T | 1 |
| An, YT; Li, J; Wang, T; Wu, ZZ; Yan, M | 1 |
| Anderson, S; He, Y; Hou, PY; Mi, C; Wang, SQ; Wu, XH; Yu, F; Zhang, J; Zhang, YW | 1 |
| Gao, L; Jiang, J; Kong, X; Li, L; Lin, H; Liu, X; Niu, Y; Yang, H; Zhou, Y | 1 |
| Chen, G; Ko, CH; Leung, PC; Li, KK; Tan, ML | 1 |
| Minakuchi, N; Miyata, Y; Murakami, A; Sakazaki, F; Tanaka, R | 1 |
| Gui, D; Guo, Y; Jiang, Q; Wang, N | 1 |
| Guo, L; Hui, J; Hui, W; Li, L; Qinghua, H; Yongde, C; Yongliang, Y; Zhonglin, Y | 1 |
| Ashizawa, N; Iwanaga, T; Matsumoto, K; Saitoh, K; Taniguchi, T | 1 |
| Chiu, CC; Chuang, HL; Ho, ST; Huang, CC; Lin, CY; Lin, LC; Liu, YL; Tung, YT; Wu, JH | 1 |
| Gopal, S; Rangappa, KS; Sathisha, KR | 1 |
| Feng, GH; Gao, LH; Li, L; Liu, HY; Liu, J; Liu, X; Niu, Y | 1 |
| Li, H; Lin, L; Su, G; Wang, Y; Zhao, M | 1 |
| Chen, J; Wang, M; Zhang, N; Zhao, J | 1 |
| Cho, SS; Ki, SH; Park, DH; Yoon, IS | 1 |
| Hsu, CL; Jhang, JJ; Liao, JW; Lin, JH; Lu, CC; Ong, JW; Yen, GC | 1 |
| Hongyan, L; Jie, R; Suling, W; Weina, Z; Yajie, Z | 1 |
| Furuhashi, H; Higashiyama, M; Hokari, R; Komoto, S; Kurihara, C; Maruta, K; Matsuo, H; Miura, S; Nagao, S; Narimatsu, K; Okada, Y; Sato, H; Shirakabe, K; Takajo, T; Tomita, K; Watanabe, C; Yasutake, Y; Yoshikawa, K | 1 |
| Li, ZL; Ma, KL; Tang, DH; Wang, CY; Ye, YS; Zheng, H | 1 |
| Asakawa, S; Hosoyamada, M; Kumagai, T; Morimoto, C; Nakamura, T; Shibata, S; Shiraishi, T; Tamura, Y; Uchida, S | 1 |
| Cheng, L; Hu, YJ; Li, LN; Liang, WQ; Liu, PG; Pu, JB; Xu, P; Yang, QQ; Zhang, HJ; Zhang, YQ; Zhou, J | 1 |
| Dong, XY; Li, Z; Li, ZJ; Lu, LF; Wang, CL | 1 |
| Chen, Q; Jin, L; Li, J; Liu, J; Wang, T; Wang, W; Yu, H; Zhang, Y | 1 |
| Cheng, P; Fang, J; Jiao, R; Li, T; Li, Y; Li, Z; Liu, X; Ma, Y; Tang, J; Wang, M; Wei, X; Xing, Y | 1 |
| Chen, N; Chu, S; He, F; Li, D; Liao, L; Lu, W; Nong, Z; Su, H; Su, Q; Wang, L; Wei, B; Wei, G; Ya, Q; Zeng, X; Zhao, J | 1 |
| Dohgu, S; Fukae, J; Kataoka, Y; Koga, M; Matsumoto, J; Nakashima, A; Takata, F; Tsuboi, Y; Yamauchi, A | 1 |
| Bai, W; Gao, L; Jiang, J; Li, L; Lin, H; Niu, Y; Tang, Y; Yang, H | 1 |
| Blas-Marron, MG; Frank, DN; García-Arroyo, FE; Gonzaga, G; Ir, D; Irvin, A; Johnson, RJ; Muñoz-Jiménez, I; Ranganathan, N; Ranganathan, P; Robertson, CE; Sánchez-Lozada, LG; Silverio, O; Soto, V; Tapia, E; Vyas, U | 1 |
| Barba, FJ; He, J; Li, S; Lorenzo, JM; Zhan, S; Zhang, R; Zhu, Z | 1 |
| Blas-Marron, MG; García-Arroyo, FE; Glaser, J; Gonzaga, G; Johnson, RJ; Madero, M; Muñoz-Jimenez, I; Osorio-Alonso, H; Roncal-Jiménez, CA; Sánchez-Lozada, LG; Silverio, O; Tapia, E; Weiss, I | 1 |
| Ma, Y; Rao, Z; Sun, X; Wu, X; Xi, D; Zhang, G | 1 |
| Li, Q; Wang, F; Xing, C; Zhang, Y | 1 |
| Bian, W; Hu, Y; Liu, N; Meng, B; Sun, J; Wang, S; Wang, Y; Xiong, Z; Yang, M; Yang, X; Yin, S; Zeng, L | 1 |
| Choi, CH; Choi, CY; Kang, BY; Kim, JR; Kim, SJ; Kim, YR; Na, CS; Oh, DR | 1 |
| Che, K; Fei, H; Hou, X; Wang, J; Wang, Y; You, W; Zou, Y | 1 |
| Komori, H; Morokado, F; Nakanishi, T; Nishizawa, K; Tamai, I; Yoda, N | 1 |
| Chang, Y; Liang, C; Liang, G; Nie, Y; Xiao, D; Zeng, S; Zhan, S; Zheng, Q; Zheng, X | 1 |
| Li, S; Liu, M; Ma, Q; Qin, N; Wang, C; Yang, F; Yu, M | 1 |
| Chen, JJ; Geng, CA; Hou, B; Huang, XY; Ma, YB; Peng, H; Yan, DX; Yang, TH; Zhang, XM | 1 |
| Kim, DS; Kim, JS; Lee, S; Lee, YS; Son, E; Sung, YY; Yuk, HJ | 1 |
| Dong, Y; Liu, J; Zhao, W; Zhou, H; Zhou, Z | 1 |
| Bhatt, DC; Jindal, DK; Kandav, G | 1 |
| Harada-Shiba, M; Hirata, H; Ogura, M; Ota-Kontani, A; Tsuchiya, Y | 1 |
| Liang, ML; Su, WK; Sun, Y; Wang, HT; Xu, WH; Xue, ZC | 1 |
| Ha, EH; Hu, Q; Li, H; Li, Z; Pang, J; Tian, S; Wang, W; Zhou, M | 1 |
| Asakawa, S; Hosoyamada, M; Kuribayashi-Okuma, E; Li, J; Morimoto, C; Murase, T; Nakamura, T; Nemoto, Y; Shibata, S; Tamura, Y; Uchida, S | 1 |
| Abbasi, WM; Ahmad, S; Arshad, MA; Ayaz, S; Bilal, M; Ghauri, AO; Nawaz, A; Rehman, T | 1 |
| Hossain, I; Ishaq, M; Mehmood, A; Nadeem, M; Naveed, M; Raka, RN; Usman, M; Wang, C; Zad, OD; Zhao, L | 1 |
| Gong, M; Han, B; Li, Z; Qiu, Y; Zou, Z | 1 |
| Bao, R; Chen, Q; Liu, L; Liu, M; Wang, D; Wang, T; Wen, S; Yu, H; Zhang, Y | 1 |
| Cao, Y; Chen, Y; Jiang, Y; Li, L; Li, Y; Lin, C; Pang, J; Tian, Y; Wu, T; Yang, Y; Zhao, Z; Zhou, P | 1 |
| Affes, H; Charfi, S; Dhouibi, R; Hammami, S; Jamoussi, K; Ksouda, K; Marekchi, R; Moalla, D; Sahnoun, Z; Salem, MB; Zeghal, KM | 1 |
| Lin, L; Peng, A; Tian, Y; Zhao, K; Zhao, M | 1 |
| Chen, H; Guan, K; Ma, Y; Qi, X; Wang, R | 1 |
| Hou, X; Liu, X; Tian, J; Wang, B; Xiang, L; Xie, B; Zhou, D | 1 |
| Hu, N; Lin, Y; Wang, J; Wang, S; Wang, X; Zhang, B; Zhao, X; Zhou, X | 1 |
| Cao, Y; Chen, Y; Huang, Q; Jiang, Y; Li, L; Li, Y; Luo, J; Pang, J; Wu, T; Zhang, L; Zhao, Z; Zhou, P | 1 |
| Chen, SH; Dong, YJ; He, XL; Li, B; Li, LZ; Lv, GY; Wang, YZ; Xu, WF; Yu, QX; Zheng, X; Zhou, C; Zhu, LJ | 1 |
| Fang, J; Guo, Y; Ma, Q; Qin, N; Shi, W; Wang, C; Wang, L; Xu, G; Yang, F; Yu, X | 1 |
| Cai, J; Chen, J; Gao, C; Jiang, L; Liu, Y; Su, Z; Wei, L; Wu, X; Wu, Y; Xiao, S; Xu, L | 1 |
| Chen, TX; Dong, L; Fu, Y; Guan, HY; He, X; Liao, SG; Tang, KF; Xu, GB; Yang, XS; Yang, YX; Zhang, CL; Zhang, JJ; Zhu, QF | 1 |
| Kim, DS; Sung, YY | 1 |
| Chen, J; Huang, Z; Jiang, L; Li, Y; Lin, G; Lin, Z; Liu, Y; Mai, L; Su, Z; Xie, J; Xu, L; Yu, Q | 1 |
| Chen, Y; Liu, T; Yang, Z; Yuan, F; Zhang, L; Zhang, S; Zhou, X; Zhuang, J | 1 |
| Guo, S; Hu, SS; Lu, PF; Meng, FH; Wang, ZR; Zhang, TJ; Zhang, X; Zhang, Y; Zhang, ZH | 1 |
| Hu, BY; Luo, XD; Ma, DY; Xiang, ML; Zhao, LX; Zhao, YL | 1 |
| Abukhalil, MH; Ahmeda, AF; Alotaibi, MF; ALRashdi, BM; Alruhaimi, RS; Alzoghaibi, MA; Arab, HH; Azab, MS; Elgebaly, HA; Germoush, MO; Kamel, EM; Mahmoud, AM; Qarmush, MM | 1 |
| Cai, M; Chen, S; Gao, X; Hu, H; Huang, L; Li, X; Liang, D; Liu, Y; Wu, Q; Xiao, C; Xie, Y; Yong, T | 1 |
| Chen, C; Chen, FA; Chen, HC; Chiu, PY; Li, YL; Wang, CC | 1 |
| Diao, X; Guan, H; Lin, H; Wang, X; Xiao, J; Xu, Y; Ye, Z; Zheng, Y; Zhou, X | 1 |
| Cai, J; Gao, C; Jiang, L; Lin, Y; Qu, C; Su, Z; Wu, Y; Yi, X; Zeng, H | 1 |
| Eräranta, A; Honkanen, T; Kurra, V; Lakkisto, P; Mustonen, J; Myllymäki, J; Paavonen, T; Pörsti, I; Riutta, A; Tikkanen, I | 1 |
| Du, L; Shen, Y; Su, E; Wei, D; Xie, D; Xie, J | 1 |
| Chen, J; Gong, S; Li, Y; Lin, Y; Liu, Y; Su, Z; Wu, X; Xie, Q; Yan, F; Zhong, L | 1 |
| Chang, Z; Chen, Y; Cui, Y; Gao, Y; Hu, Q; Huang, Y; Liu, Y; Luo, X; Wang, B; Wang, S; Wang, Z; Yuan, J; Zhang, L; Zhou, L | 1 |
| An, J; Li, C; Li, Y; Lin, F; Ma, S; Wang, S; Xie, Y; Xu, L; Zhang, Y; Zhao, Y | 1 |
3 review(s) available for uric acid and oxonic acid
| Article | Year |
|---|---|
Use of the uricase-inhibited rat as an animal model in toxicology.
Topics: Aggression; Animals; Diet; Disease Models, Animal; Dogs; Embryo, Mammalian; Female; Gout; Humans; Kidney Diseases; Oxonic Acid; Pregnancy; Rats; Stress, Physiological; Triazines; Urate Oxidase; Uric Acid | 1978 |
[Animal model for gout].
Topics: Animals; Chickens; Disease Models, Animal; Female; Gout; Male; Mice; Oxonic Acid; Poultry Diseases; Rats; Urate Oxidase; Uric Acid | 1982 |
Uric acid--a uremic toxin?
Topics: Animals; Arteriosclerosis; Biomarkers; Enzyme Inhibitors; Humans; Hypertension; Hypertrophy; Hyperuricemia; Kidney; Kidney Diseases; Oxonic Acid; Rats; Urate Oxidase; Uric Acid | 2006 |
182 other study(ies) available for uric acid and oxonic acid
| Article | Year |
|---|---|
Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic beta-cells.
Topics: Animals; Arginine; Glucose; Hyperuricemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Protein Binding; Rats; Structure-Activity Relationship; Uric Acid | 2005 |
Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.
Topics: Amino Acid Sequence; Biocatalysis; Computational Biology; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Humans; Leishmania major; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Protein Structure, Tertiary; Sequence Alignment; Stereoisomerism; Structure-Activity Relationship; Trypanosoma cruzi | 2010 |
Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy.
Topics: Animals; Blood Pressure; Diabetes Insipidus; Diuresis; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Inulin; Kidney; Male; Osmolar Concentration; Oxonic Acid; p-Aminohippuric Acid; Rats; Regional Blood Flow; Triazines; Uric Acid | 1977 |
Physiological characteristics of various experimental models for the study of disorders in purine metabolism.
Topics: Acidosis; Alkalosis; Allopurinol; Animals; Cholesterol; Disease Models, Animal; Diuresis; Fructose; Glycine; Gout; Hydrogen-Ion Concentration; Natriuresis; Oxonic Acid; Probenecid; Purines; Rats; Research Design; Species Specificity; Triazines; Triglycerides; Uric Acid | 1977 |
High steady-state levels of uric acid produced in rats by dietary training and potassium oxonate.
Topics: Animals; Diet; Disease Models, Animal; Feeding Behavior; Male; Oxonic Acid; Rats; Time Factors; Triazines; Uric Acid | 1979 |
Diurnal variation in serum uric acid of rats fed potassium oxonate.
Topics: Animals; Circadian Rhythm; Diet; Female; Oxonic Acid; Rats; Triazines; Uric Acid | 1978 |
Platelet aggregation in rats in relation to hyperuricaemia induced by dietary single-cell protein and to protein deficiency.
Topics: Animals; Dietary Proteins; Female; Oxonic Acid; Platelet Aggregation; Protein Deficiency; Rats; Uric Acid | 1978 |
Oxonate-induced hyperuricemia and orotic aciduria in mice.
Topics: Administration, Oral; Animals; Kidney; Liver; Male; Mice; Organ Size; Orotic Acid; Oxonic Acid; Triazines; Uric Acid | 1978 |
Determination of uric acid in biological fluids by high-pressure liquid chromatography.
Topics: Adult; Animals; Chromatography, High Pressure Liquid; Humans; Mice; Oxonic Acid; Uric Acid | 1978 |
[Inhibition of adjuvant arthritis by oxonate: influence of uricemia (author's transl)].
Topics: Animals; Arthritis; Arthritis, Experimental; Diet; Male; Oxonic Acid; Rats; Triazines; Uric Acid | 1978 |
Inhibition of adjuvant-induced arthritis in the hyperuricemic rat.
Topics: Animals; Arthritis; Arthritis, Experimental; Diet; Male; Oxonic Acid; Rats; Time Factors; Uric Acid | 1978 |
Allantoxanamide: a potent new uricase inhibitor in vivo.
Topics: Animals; Female; Kidney Tubules; Oxonic Acid; Rats; Time Factors; Triazines; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1978 |
[Study on mechanism of urate stone formation. I. Light microscopic study (author's transl)].
Topics: Animals; Body Weight; Kidney; Kidney Calculi; Kidney Tubules; Male; Oxonic Acid; Rats; Uric Acid | 1978 |
[Study on mechanism of urate stone formation. II. Electron microscopic study (author's transl)].
Topics: Animals; Kidney; Kidney Calculi; Kidney Glomerulus; Kidney Tubules; Male; Oxonic Acid; Rats; Uric Acid | 1978 |
Studies on the influence of ethanol and of lactic acid on uric acid metabolism.
Topics: Alkalosis; Animals; Bicarbonates; Ethanol; Fructose; Humans; Lactates; Oxonic Acid; Rats; Sodium; Urate Oxidase; Uric Acid | 1977 |
Carbohydrate induced increase in uric acid synthesis. Studies in human volunteers and in laboratory rats.
Topics: Adenine Nucleotides; Allopurinol; Animals; Carbohydrates; Dose-Response Relationship, Drug; Fructose; Glucose; Humans; Kinetics; Lactates; Liver; Oxonic Acid; Rats; Sorbitol; Species Specificity; Urate Oxidase; Uric Acid; Xylitol | 1977 |
Suppression of experimental urate nephropathy by salicylate.
Topics: Animals; Nephritis; Oxonic Acid; Rats; Salicylates; Triazines; Uric Acid | 1977 |
Sites of urate transport in the rat nephron.
Topics: Animals; Biological Transport; Hepatectomy; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Loop of Henle; Oxonic Acid; Perfusion; Rats; Urate Oxidase; Uric Acid | 1977 |
Diet-induced hyperuricaemia and platelet aggregation in rats.
Topics: Animals; Diet; Fusarium; Kidney; Nucleic Acids; Oxonic Acid; Platelet Aggregation; Rats; Time Factors; Triazines; Uric Acid | 1977 |
Influence of sugar substitutes and of ethanol on purine metabolism.
Topics: Animals; Carbohydrates; Ethanol; Fructose; Humans; Infusions, Parenteral; Lactates; Oxonic Acid; Purines; Time Factors; Uric Acid; Xylitol | 1977 |
Renal excretion of allantoin in rats: a micropuncture and clearance study.
Topics: Allantoin; Animals; Biological Transport; Glomerular Filtration Rate; Inulin; Kidney Function Tests; Kidney Tubules; Male; Oxonic Acid; Pyrazinamide; Rats; Uric Acid | 1977 |
Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis.
Topics: Animals; Arteriosclerosis; Female; Hyperglycemia; Hyperlipidemias; Hypertension; Male; Oxonic Acid; Rats; Reproduction; Uric Acid | 1977 |
Alterations of renal function during dietary-induced hyperuricemia in the rat.
Topics: Acute Kidney Injury; Animals; Diet; Female; Glomerular Filtration Rate; Insulin; Kidney; Oxonic Acid; Rats; Uric Acid | 1976 |
Renal urate excretion at various plasma concentrations in the rat: a free-flow micropuncture study.
Topics: Animals; Hemolysis; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Male; Oxonic Acid; Rats; Uric Acid | 1976 |
Platelet aggregation in rats made hyperuricaemic with nucleic adid-rich diets containing oxonate, and inhibitor of uricase [proceedings].
Topics: Animals; Diet; Disease Models, Animal; Female; Fusarium; Gout; Nucleic Acids; Oxonic Acid; Platelet Aggregation; Rats; Triazines; Urate Oxidase; Uric Acid | 1976 |
Some in vivo effects in the rat induced by chlorprothixene and potassium oxonate.
Topics: Animals; Blood Coagulation; Blood Platelets; Chlorprothixene; Female; Hematocrit; Oxonic Acid; Rats; Stimulation, Chemical; Time Factors; Triazines; Uric Acid | 1975 |
Chronic experimental hyperuricemic nephropathy.
Topics: Animals; Disease Models, Animal; Gout; Kidney; Kidney Calculi; Nephritis, Interstitial; Oxonic Acid; Rats; Uric Acid | 1975 |
A brief note on the ultrastructure of renal glomeruli in acutely hyperuricemic rats.
Topics: Animals; Kidney Diseases; Kidney Glomerulus; Male; Oxonic Acid; Rats; Uric Acid | 1976 |
Effect of fructose administration on serum urate levels in the uricase inhibited rat.
Topics: Animals; Female; Fructose; Male; Oxonic Acid; Rats; Triazines; Urate Oxidase; Uric Acid | 1976 |
Hyperuricemia induced by the uricosuric drug probenecid in rats.
Topics: Allopurinol; Animals; Hepatectomy; Hypoxanthines; Inulin; Kidney Function Tests; Male; Oxonic Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Uric Acid; Xanthines | 1991 |
Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products.
Topics: Allantoin; Ceruloplasmin; Chromatography, High Pressure Liquid; Edetic Acid; Ferric Compounds; Hemoglobins; Hydantoins; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Hypochlorous Acid; Hypoxanthine; Hypoxanthines; Imidazoles; Kinetics; Molecular Structure; Myoglobin; Oxidation-Reduction; Oxonic Acid; Uric Acid; Xanthine Oxidase | 1990 |
Effects of uric acid and caffeine on A1 adenosine receptor binding in developing rat brain.
Topics: Adenosine; Aging; Animals; Binding, Competitive; Brain; Caffeine; Male; Oxonic Acid; Rats; Rats, Inbred Strains; Receptors, Purinergic; Time Factors; Uric Acid | 1990 |
Urate excretion by the isolated perfused rat kidney and modification by drugs.
Topics: Animals; Furosemide; Glomerular Filtration Rate; Kidney; Natriuresis; Oxonic Acid; Perfusion; Probenecid; Pyrazinamide; Rats; Salicylates; Salicylic Acid; Uric Acid | 1989 |
Hyperuricemia and locomotor activity in developing rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Male; Motor Activity; Oxonic Acid; Rats; Rats, Inbred Strains; Time Factors; Triazines; Urate Oxidase; Uric Acid | 1989 |
Decreasing effect of allantoxanamide, a hyperuricemic agent on renal functions in rats.
Topics: Animals; Diuresis; Kidney; Male; Mannitol; Nephrectomy; Organ Size; Oxonic Acid; Rats; Rats, Inbred Strains; Triazines; Uric Acid | 1987 |
Effect of isoproterenol on renal uric acid excretion in rats.
Topics: Allopurinol; Animals; Blood Pressure; Isoproterenol; Male; Oxonic Acid; Phenylephrine; Rats; Rats, Inbred Strains; Uric Acid | 1987 |
Carrier-mediated concentrative urate transport in rat renal membrane vesicles.
Topics: Animals; Biological Transport; Copper; Diffusion; Hydrogen-Ion Concentration; Kidney; Male; Microvilli; Osmolar Concentration; Oxonic Acid; Pyrazinamide; Rats; Uric Acid | 1985 |
[The effect of fructose on uric acid metabolism].
Topics: Allopurinol; Animals; Diuresis; Fasting; Fructose; Gout; Humans; Male; Oxonic Acid; Rats; Urate Oxidase; Uremia; Uric Acid | 1974 |
[Effects of some drugs on plasma uric acid in rats--actions of catecholamines and beta-blocking agents].
Topics: Adrenergic beta-Antagonists; Allantoin; Animals; Catecholamines; Drug Interactions; Epinephrine; Isoproterenol; Male; Norepinephrine; Oxonic Acid; Phenylephrine; Rats; Rats, Inbred Strains; Uric Acid | 1984 |
Effects of uricosuric drugs and diuretics on uric acid excretion in oxonate-treated rats.
Topics: Animals; Diuretics; Kidney; Male; Oxonic Acid; Probenecid; Rats; Rats, Inbred Strains; Triazines; Uric Acid; Uricosuric Agents | 1983 |
Uricostatic effect of allopurinol in the allantoxanamide-treated rat: a new method for evaluating antiuricopathic drugs.
Topics: Allopurinol; Animals; Kinetics; Male; Oxonic Acid; Rats; Rats, Inbred Strains; Triazines; Urate Oxidase; Uric Acid | 1984 |
Pharmacological effects of 1,3,5-triazines and their excretion characteristics in the rat.
Topics: Animals; Kidney; Kinetics; Male; Oxonic Acid; Purines; Rats; Structure-Activity Relationship; Triazines; Uracil; Urate Oxidase; Uric Acid | 1980 |
Adjuvant polyarthritis. VI. Effect of oxonate-induced hyperuricemia on the development of acute inflammation, immune response and adjuvant arthritis.
Topics: Animals; Antibody Formation; Arthritis; Arthritis, Experimental; Cell Line; Diet; Edema; Immunity, Cellular; Inflammation; Neoplasms, Experimental; Oxonic Acid; Rats; Rats, Inbred Lew; Triazines; Uric Acid | 1981 |
Uric acid-induced decrease in rat insulin secretion.
Topics: Animals; Culture Techniques; Drinking Behavior; Insulin; Insulin Secretion; Islets of Langerhans; Male; Oxonic Acid; Rats; Urate Oxidase; Uric Acid | 1981 |
Allantoxanamide-induced myocardial necrosis in Sprague-Dawley vs spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Corticosterone; Female; Heart; Hypertension; Lipids; Male; Myocardium; Oxonic Acid; Rats; Rats, Inbred Strains; Triazines; Urate Oxidase; Uric Acid | 1982 |
Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats.
Topics: Allantoin; Animals; Antihypertensive Agents; Male; Models, Biological; Oxonic Acid; Rats; Stimulation, Chemical; Triazines; Uric Acid; Uricosuric Agents | 1980 |
Renal function in rats with acute medullary injury.
Topics: Acute Kidney Injury; Animals; Calcium; Diet; Disease Models, Animal; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Inulin; Kidney Medulla; Kidney Tubules; Male; Oxonic Acid; Potassium; Rats; Uric Acid | 1980 |
Interaction of hyperuricuria and hyperoxaluria on renal calcium oxalate stone formation.
Topics: Animals; Calcium Oxalate; Ethylene Glycols; Kidney; Kidney Calculi; Male; Oxonic Acid; Rats; Uric Acid | 1980 |
Uric acid and allantoin in rat liver after oxonic acid and 14C-formate.
Topics: Allantoin; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Formates; Liver; Male; Oxonic Acid; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Uric Acid | 1994 |
Hypouricemic and uricosuric actions of AA-193 in a hyperuricemic rat model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Isoxazoles; Kidney; Liver; Male; Oxonic Acid; Rats; Rats, Wistar; Time Factors; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Dehydrogenase | 1994 |
Functional analysis and molecular modeling of a cloned urate transporter/channel.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Cloning, Molecular; Lipid Bilayers; Models, Molecular; Molecular Sequence Data; Organic Anion Transporters; Oxonic Acid; Pyrazinamide; Rats; Receptors, Purinergic P1; Sequence Homology, Amino Acid; Structure-Activity Relationship; Urate Oxidase; Uric Acid; Xanthine | 1999 |
Nigrostriatal catecholamine metabolism in guinea pigs is altered by purine enzyme inhibition.
Topics: 3,4-Dihydroxyphenylacetic Acid; Allopurinol; Animals; Catecholamines; Corpus Striatum; Dopamine; Enzyme Inhibitors; Guinea Pigs; Injections; Male; Norepinephrine; Oxonic Acid; Substantia Nigra; Uric Acid | 1999 |
Purine nucleotide catabolism in rat liver: labelling of uric acid and allantoin after treatment with oxonic acid and allopurinol.
Topics: Allantoin; Allopurinol; Animals; Enzyme Inhibitors; Liver; Male; Oxonic Acid; Purine Nucleotides; Rats; Rats, Wistar; Uric Acid | 2001 |
Hyperuricemia exacerbates chronic cyclosporine nephropathy.
Topics: Animals; Chronic Disease; Collagen; Crystallization; Cyclosporine; Enzyme Inhibitors; Immunosuppressive Agents; Kidney; Kidney Diseases; Macrophages; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Osteopontin; Oxonic Acid; Rats; Rats, Sprague-Dawley; Reference Values; Sialoglycoproteins; Urate Oxidase; Uric Acid | 2001 |
Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity.
Topics: Allopurinol; Animals; Dose-Response Relationship, Drug; Esculin; Liver; Male; Mice; Mice, Inbred ICR; Models, Animal; Oleaceae; Oxonic Acid; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Time Factors; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2002 |
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Benzofurans; Blood Pressure; Diuretics; Enalapril; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Muscle, Smooth, Vascular; Oxonic Acid; Rats; Rats, Sprague-Dawley; Sodium Chloride Symporter Inhibitors; Sodium Chloride, Dietary; Uric Acid; Uricosuric Agents; Vascular Diseases | 2002 |
Mild hyperuricemia induces glomerular hypertension in normal rats.
Topics: Animals; Arterioles; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Hypertrophy; Kidney Glomerulus; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Uric Acid | 2002 |
Therapeutic intervention in experimental allergic encephalomyelitis by administration of uric acid precursors.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Inosine; Inosine Monophosphate; Mice; Molsidomine; Monocytes; Multiple Sclerosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxidative Stress; Oxonic Acid; Peroxynitrous Acid; Urate Oxidase; Uric Acid; Xanthines | 2002 |
The oxidation of uric acid to oxonic acid (allantoxanic acid) and its application in tracer studies of uric acid biosynthesis.
Topics: Indicators and Reagents; Oxidation-Reduction; Oxonic Acid; Uric Acid | 1954 |
On the nature of oxonic acid and allantoxaidin as oxidation products of uric acid and allantoin.
Topics: Allantoin; Humans; Hydantoins; Oxidation-Reduction; Oxonic Acid; Uric Acid | 1955 |
Complexed and ligand-free high-resolution structures of urate oxidase (Uox) from Aspergillus flavus: a reassignment of the active-site binding mode.
Topics: Amino Acid Sequence; Animals; Aspergillus flavus; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Fungal Proteins; Humans; Mice; Molecular Conformation; Molecular Sequence Data; Oxonic Acid; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Urate Oxidase; Uric Acid; Xanthines | 2004 |
Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.
Topics: Allopurinol; Animals; Antioxidants; Biflavonoids; Catechin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Proanthocyanidins; Seeds; Time Factors; Urate Oxidase; Uric Acid; Vitis; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Topics: Animals; Flavonoids; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Plant Leaves; Quercetin; Rutin; Thuja; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
[Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats].
Topics: Animals; Anti-Infective Agents; Brazil; Caffeic Acids; China; Coumaric Acids; Disease Models, Animal; Flavonoids; Gout; Hyperuricemia; Male; Oxonic Acid; Phenylethyl Alcohol; Phenylpropionates; Propionates; Propolis; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2005 |
The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Creatinine; Enzyme Inhibitors; Flavonoids; Hyperuricemia; In Vitro Techniques; Kidney; Kinetics; Male; Microvilli; Oxonic Acid; Rats; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2006 |
Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Topics: Administration, Oral; Allopurinol; Animals; Cinnamomum aromaticum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperuricemia; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Bark; Plant Oils; Time Factors; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2006 |
Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats.
Topics: Administration, Oral; Allopurinol; Animals; Chrysanthemum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Esters; Flavones; Hyperuricemia; Inhibitory Concentration 50; Injections, Intraperitoneal; Liver; Male; Oxonic Acid; Quinic Acid; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2005 |
Effect and mechanism of total saponin of Dioscorea on animal experimental hyperuricemia.
Topics: Animals; Dioscorea; Disease Models, Animal; Hyperuricemia; Injections, Intraperitoneal; Liver; Male; Mice; Oxonic Acid; Rats; Rats, Wistar; Saponins; Uric Acid; Xanthine Oxidase; Yeasts | 2006 |
Xanthine oxidase inhibitory activity of some Indian medical plants.
Topics: Animals; Female; Hyperuricemia; India; Lethal Dose 50; Magnoliopsida; Male; Medicine, Traditional; Mice; Oxonic Acid; Plant Extracts; Plant Leaves; Plants, Medicinal; Uric Acid; Xanthine Oxidase | 2007 |
Uric acid heralds ischemic tissue injury to mobilize endothelial progenitor cells.
Topics: Adenosine; Animals; Cell Movement; Chronic Disease; Endothelial Cells; Hyperuricemia; Inosine; Ischemia; Ischemic Preconditioning; Kidney; Mice; Mice, Inbred Strains; Oxonic Acid; Stem Cells; Urate Oxidase; Uric Acid | 2007 |
The endogenous danger signal uric Acid augments contact hypersensitivity responses in mice.
Topics: Animals; B7-2 Antigen; CD40 Antigens; Chlorobenzenes; Dendritic Cells; Dermatitis, Contact; Drug Synergism; Ear, External; Edema; Immunity, Cellular; Injections, Subcutaneous; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Oxonic Acid; Signal Transduction; T-Lymphocyte Subsets; Uric Acid | 2007 |
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia.
Topics: Animals; Blood Pressure; Febuxostat; Follow-Up Studies; Gout Suppressants; Hypertension, Renal; Hyperuricemia; Kidney Glomerulus; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Thiazoles; Uric Acid; Xanthine Oxidase | 2008 |
Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice.
Topics: Animals; Glycosides; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Plant Roots; Scrophularia; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2008 |
Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency.
Topics: Aldosterone; Animal Feed; Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Hypertension, Renal; Hyperuricemia; Male; Nephrectomy; Oxonic Acid; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Insufficiency, Chronic; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; Uric Acid | 2008 |
Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice.
Topics: Acrolein; Administration, Oral; Allopurinol; Animals; Cinnamomum; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Inhibitory Concentration 50; Male; Mice; Mice, Inbred ICR; Oils, Volatile; Oxonic Acid; Plant Extracts; Plant Leaves; Plant Oils; Taiwan; Uric Acid; Xanthine Oxidase | 2008 |
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Benzofurans; Depsides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hyperuricemia; Inflammation; Male; Molecular Conformation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxonic Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Uric Acid; Xanthine Oxidase | 2008 |
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensins; Animals; Cells, Cultured; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Hypertension; Hyperuricemia; KATP Channels; Kidney; Kidney Diseases; Male; Nitric Oxide; Oxonic Acid; Propylamines; Rats; Rats, Sprague-Dawley; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2008 |
Hyperuricemia, oxidative stress, and carotid artery tone in experimental renal insufficiency.
Topics: Animals; Carotid Arteries; Creatinine; Dinoprost; Hyperuricemia; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Oxidative Stress; Oxonic Acid; Peroxides; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Uric Acid; Vasodilation | 2009 |
Relative efficacy of casein or soya protein combined with palm or safflower-seed oil on hyperuricaemia in rats.
Topics: Albumins; Analysis of Variance; Animals; Blood Urea Nitrogen; Caseins; Cholesterol; Creatinine; Diet; Dietary Fats; Dietary Proteins; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Glycine max; Hyperuricemia; Insulin; Interferon-gamma; Kidney; Kidney Calculi; Male; Nephritis, Interstitial; Nitric Oxide; Oxonic Acid; Palm Oil; Plant Oils; Rats; Rats, Wistar; Safflower Oil; Soybean Proteins; Transforming Growth Factor beta; Triglycerides; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid | 2010 |
Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice.
Topics: Allopurinol; Animals; Biological Transport; Gout; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred Strains; Organic Anion Transporters; Oxonic Acid; Reverse Transcriptase Polymerase Chain Reaction; Uric Acid | 2010 |
Phytochemicals from Acacia confusa heartwood extracts reduce serum uric acid levels in oxonate-induced mice: their potential use as xanthine oxidase inhibitors.
Topics: Acacia; Animals; Drug Discovery; Enzyme Inhibitors; Flavonoids; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Urate Oxidase; Uric Acid; Wood; Xanthine Oxidase | 2010 |
Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Colitis; Dietary Supplements; Drug Synergism; Enzyme Inhibitors; Inflammation Mediators; Inflammatory Bowel Diseases; Inosine Monophosphate; Lipid Peroxidation; Macrophages; Male; Neutrophil Infiltration; Oxonic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Urate Oxidase; Uric Acid | 2010 |
Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.
Topics: Allopurinol; Animals; Aorta; Arginine; Benzbromarone; Biological Transport; Blood Pressure; Cationic Amino Acid Transporter 1; Disease Models, Animal; Hyperuricemia; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxonic Acid; Phosphorylation; Protein Kinase C-alpha; Rats; Rats, Wistar; Tyrosine; Uric Acid; Uricosuric Agents | 2011 |
[Mangiferin promotes uric acid excretion and kidney function improvement and modulates related renal transporters in hyperuricemic mice].
Topics: Animals; Blood Urea Nitrogen; Carrier Proteins; Creatinine; Glucose Transport Proteins, Facilitative; Hyperuricemia; Kidney; Male; Membrane Proteins; Mice; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Protective Agents; Random Allocation; RNA, Messenger; Solute Carrier Family 22 Member 5; Symporters; Uric Acid; Uromodulin; Xanthones | 2010 |
Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice.
Topics: Allopurinol; Animals; Anthocyanins; Disease Models, Animal; Hyperuricemia; Ipomoea batatas; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Uric Acid | 2011 |
Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice.
Topics: Aesculus; Animals; Coumarins; Drugs, Chinese Herbal; Gene Expression Regulation; Hyperuricemia; Kidney; Male; Membrane Transport Proteins; Mice; Oxonic Acid; Uric Acid | 2011 |
Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Asteraceae; Ethanol; Flavonoids; Hyperuricemia; Inflammation; Liver; Male; Mice; Oxonic Acid; Phytotherapy; Plant Components, Aerial; Plant Extracts; Solvents; Uric Acid; Xanthine Oxidase | 2012 |
Hypouricemic effect of the methanol extract from Prunus mume fruit in mice.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Hyperuricemia; Liver; Male; Medicine, East Asian Traditional; Methanol; Mice; Oxonic Acid; Plant Extracts; Prunus; Uric Acid; Xanthine Oxidase | 2012 |
Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Urea Nitrogen; Carrier Proteins; Creatinine; Disaccharides; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Glucosides; Gout Suppressants; Hyperuricemia; Kidney; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Resveratrol; Solute Carrier Family 22 Member 5; Stilbenes; Symporters; Uric Acid | 2012 |
Reducing effect of mangiferin on serum uric acid levels in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Mice, Inbred Strains; Oxonic Acid; Time Factors; Toxicity Tests, Acute; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthones | 2012 |
Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase activity.
Topics: Allopurinol; Animals; Glucose Transporter Type 1; Gout; Gout Suppressants; Hyperuricemia; Hypoxanthine; Kidney; Liver; Male; Monosaccharide Transport Proteins; Oxonic Acid; Phytotherapy; Plant Extracts; Polyphenols; Rats; Rats, Sprague-Dawley; Sapindaceae; Seeds; Uric Acid; Xanthine Oxidase | 2012 |
The influence of oxonate-induced hyperuricemia and allopurinol on behavioral reactions of random-bred mice.
Topics: Allopurinol; Animals; Behavior, Animal; Hindlimb Suspension; Male; Maze Learning; Mice; Motor Activity; Oxonic Acid; Uric Acid | 2012 |
The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Biomarkers, Pharmacological; Disease Models, Animal; Edema; Hyperalgesia; Hyperuricemia; Jatropha; Male; Motor Activity; Neutrophil Infiltration; Oxonic Acid; Peroxidase; Phytotherapy; Plant Extracts; Rats; Stomach Ulcer; Uric Acid; Xanthine Oxidase | 2013 |
Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats.
Topics: Animals; Beverages; Fatty Liver; Fructokinases; Fructose; Glucose; Hypertrophy; Hyperuricemia; Insulin Resistance; Kidney; Kidney Diseases; Liver; Male; Metabolic Syndrome; Oxidative Stress; Oxonic Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Urate Oxidase; Uric Acid; Vasoconstriction | 2013 |
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP).
Topics: Acute-Phase Proteins; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; HEK293 Cells; Humans; Hyperuricemia; Kynurenic Acid; Lipocalin-2; Lipocalins; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Oxonic Acid; Proto-Oncogene Proteins; Tryptophan; Uric Acid | 2013 |
Fructus Gardenia Extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3.
Topics: Animals; Blood Urea Nitrogen; Gardenia; Gene Expression Regulation; Humans; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Renal Insufficiency; Uric Acid | 2013 |
Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate.
Topics: Animals; Base Sequence; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; DNA Primers; Hypertension; Iridoid Glycosides; Kidney Diseases; Male; Nitric Oxide Synthase; Oxonic Acid; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rubiaceae; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Uric Acid; Yeasts | 2014 |
Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
Topics: Animals; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Gout; Gout Suppressants; Hyperuricemia; Kidney; Mice; Organic Anion Transporters; Oxonic Acid; Phytotherapy; Plant Roots; Rhizome; Saponins; Smilax; Uric Acid | 2014 |
[Effect of jianpihuashi decoction on rats with hyperuricemia].
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Liver; Male; Oxonic Acid; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2013 |
Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
Topics: Animals; Creatinine; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Hypertension; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Uric Acid; Xanthine Oxidase | 2014 |
In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects.
Topics: Animals; Antioxidants; Chlorogenic Acid; Coix; Coumaric Acids; Enzyme Inhibitors; Free Radical Scavengers; Hyperuricemia; Male; Oxonic Acid; Phenols; Plant Extracts; Propionates; Rats; Rats, Sprague-Dawley; Seeds; Uric Acid; Xanthine Oxidase | 2014 |
Effects of Smilaxchinoside A and Smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Glucose Transport Proteins, Facilitative; Glycosides; Hyperuricemia; Kidney; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Plant Roots; Saponins; Smilax; Steroids; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
Pallidifloside D, a saponin glycoside constituent from Smilax riparia, resist to hyperuricemia based on URAT1 and GLUT9 in hyperuricemic mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Glucose Transport Proteins, Facilitative; Hyperuricemia; Male; Medicine, Chinese Traditional; Mice; Organic Anion Transporters; Oxonic Acid; Plant Roots; Rhizome; Saponins; Smilax; Uric Acid | 2014 |
Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
Topics: Animals; Aporphines; Carrier Proteins; Cell Line; Humans; Hyperuricemia; Inflammasomes; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestines; Kidney; Male; Mice; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Organic Anion Transporters; Oxonic Acid; Signal Transduction; Toll-Like Receptor 4; Uric Acid | 2015 |
Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Bignoniaceae; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Oxonic Acid; Phytotherapy; Plant Extracts; Plant Leaves; Uric Acid; Xanthine Oxidase | 2015 |
The molecular insight into the antihyperuricemic and renoprotective effect of Shuang Qi gout capsule in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood Urea Nitrogen; Capsules; Carrier Proteins; Creatinine; Drugs, Chinese Herbal; Gout; Gout Suppressants; Hyperuricemia; Kidney; Male; Membrane Proteins; Mice, Inbred ICR; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Protective Agents; Solute Carrier Family 22 Member 5; Symporters; Uric Acid | 2015 |
Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency.
Topics: Analysis of Variance; Animals; Cardiac Output; Disease Models, Animal; Hyperuricemia; Male; Mesenteric Arteries; Nephrectomy; Oxonic Acid; Random Allocation; Rats; Renal Insufficiency, Chronic; Uric Acid; Vasoconstriction; Vasodilation | 2015 |
[Regulatory effect of leonurus extracts on hyperuricemia in rats].
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Hyperuricemia; Kidney; Leonurus; Male; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Up-Regulation; Uric Acid | 2014 |
Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice.
Topics: Allopurinol; Animals; Creatinine; Disease Models, Animal; Drug Synergism; Glucose Transport Proteins, Facilitative; Glycosides; Gout Suppressants; Hyperuricemia; Male; Mice; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Saponins; Smilax; Uric Acid; Xanthine Oxidase | 2015 |
Mangiferin Inhibits Renal Urate Reabsorption by Modulating Urate Transporters in Experimental Hyperuricemia.
Topics: Animals; Anion Transport Proteins; Carrier Proteins; Cytoskeletal Proteins; Hyperuricemia; Kidney; Male; Mice; Monosaccharide Transport Proteins; Oxonic Acid; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Xanthones | 2015 |
Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice.
Topics: Animals; Gout Suppressants; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Polyphenols; Tea; Uric Acid; Xanthine Oxidase | 2015 |
[The Xanthine Oxidase Inhibitory Activity and Hypouricemic Effects of Crude Drugs Obtained from the Silkworm in Mice].
Topics: Administration, Oral; Animals; Biological Products; Biomarkers; Blood Pressure; Bombyx; Chromatography, High Pressure Liquid; Complex Mixtures; Dermatitis, Contact; Disease Models, Animal; Enzyme Inhibitors; Hyperuricemia; Mice; Oxonic Acid; Platelet Aggregation; Uric Acid; Xanthine Oxidase | 2015 |
Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate.
Topics: Adenine; Administration, Oral; Animals; Benzbromarone; Creatinine; Drug Synergism; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Plant Exudates; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2015 |
Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3.
Topics: Animals; Elaeagnaceae; Hyperuricemia; Ion Transport; Kidney; Male; Membrane Proteins; Mice; Molecular Structure; Oleanolic Acid; Oxonic Acid; Protective Agents; Proteinuria; Uric Acid | 2016 |
Uricosuric agents decrease the plasma urate level in rats by concomitant treatment with topiroxostat, a novel xanthine oxidoreductase inhibitor.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Inosine; Male; Nitriles; Oxonic Acid; Probenecid; Pyridines; Rats; Rats, Wistar; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Dehydrogenase | 2016 |
Antioxidative phytochemicals from Rhododendron oldhamii Maxim. leaf extracts reduce serum uric acid levels in potassium oxonate-induced hyperuricemic mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Gout Suppressants; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Rhododendron; Uric Acid | 2015 |
Antihyperuricemic effects of thiadiazolopyrimidin-5-one analogues in oxonate treated rats.
Topics: Animals; Catalytic Domain; Creatinine; Enzyme Inhibitors; Hyperuricemia; Kidney; Liver; Male; Molecular Docking Simulation; Oxonic Acid; Rats; Rats, Wistar; Thiadiazoles; Uric Acid; Xanthine Oxidase | 2016 |
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity.
Topics: Administration, Oral; Animals; Biomarkers; Biotransformation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Kinetics; Mice; Molecular Structure; Oxonic Acid; Structure-Activity Relationship; Uric Acid; Xanthenes; Xanthine Oxidase; Xanthones | 2016 |
Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor.
Topics: Animals; Body Weight; Carbolines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Furans; Hyperuricemia; Male; Molecular Docking Simulation; Oxonic Acid; Rats, Sprague-Dawley; Soy Foods; Uric Acid; Xanthine Oxidase | 2016 |
Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice.
Topics: Animals; Carrier Proteins; Flavonols; Hyperuricemia; Inflammasomes; Inflammation; Janus Kinase 2; Kidney; Male; Membrane Transport Proteins; Mice; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Oxonic Acid; Podocytes; Signal Transduction; STAT3 Transcription Factor; Thioredoxins; Uric Acid | 2016 |
Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Flowers; Gout Suppressants; Hamamelidaceae; Hyperuricemia; Liver; Male; Mice, Inbred ICR; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Plants, Medicinal; Solvents; Uric Acid; Xanthine Oxidase | 2016 |
Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo.
Topics: Animals; Humans; Hyperuricemia; Lamiaceae; Liver; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Streptozocin; THP-1 Cells; Uric Acid; Xanthine Oxidase | 2016 |
Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Flavanones; Gout Suppressants; Hyperuricemia; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Treatment Outcome; Uric Acid | 2016 |
Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Disease Models, Animal; Gastrointestinal Diseases; Humans; Ileum; Indomethacin; Inosine Monophosphate; Lipid Peroxidation; Male; Mice, Inbred C57BL; Oxonic Acid; Uric Acid | 2017 |
Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis).
Topics: Acute Disease; Allopurinol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Humans; Hyperuricemia; Injections, Intraperitoneal; Liver; Oxonic Acid; RNA, Messenger; Tupaia; Urate Oxidase; Uric Acid; Xanthine Dehydrogenase | 2017 |
Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Actins; Albuminuria; Animals; Blood Pressure; Cyclic N-Oxides; Deoxyguanosine; Desmin; Disease Models, Animal; Hyperuricemia; Immunohistochemistry; Kidney Glomerulus; Male; Microscopy, Electron, Transmission; Oxidative Stress; Oxonic Acid; Rats; Rats, Sprague-Dawley; Spin Labels; Urate Oxidase; Uric Acid; Xanthine Dehydrogenase | 2017 |
Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Chromatography, High Pressure Liquid; Disease Models, Animal; Edema; Gnaphalium; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Tandem Mass Spectrometry; Uric Acid; Xanthine Oxidase | 2017 |
Hypouricemic and nephroprotective effects of total flavonoids from the residue of supercritical CO2 extraction of Humulus lupulus in potassium oxonate-induced mice.
Topics: Animals; Carbon Dioxide; Chromatography, Supercritical Fluid; Flavonoids; Humulus; Hyperuricemia; Inhibitory Concentration 50; Kidney; Male; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2017 |
Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Topics: Adenine; Animals; Biomarkers; Creatinine; Dioscorea; Diosgenin; Disease Models, Animal; Dose-Response Relationship, Drug; Glucose Transport Proteins, Facilitative; HCT116 Cells; Humans; Hyperuricemia; Intestinal Elimination; Intestinal Mucosa; Intestines; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Renal Elimination; Spirostans; Time Factors; Uric Acid; Uricosuric Agents | 2018 |
A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice.
Topics: Allopurinol; Animals; Antibodies, Monoclonal; Antibody Affinity; Antioxidants; Creatinine; Cross Reactions; Female; Immune Sera; Immunization; Immunoglobulin G; Inflammation; Kidney; Liver; Malondialdehyde; Mice; Mice, Inbred BALB C; Oxonic Acid; Protective Agents; Spleen; Superoxide Dismutase; Th1 Cells; Th2 Cells; Urea; Uric Acid; Xanthine Oxidase | 2018 |
Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ants; Hyperuricemia; Kidney; Liver; Male; Oxonic Acid; Protective Agents; Rats; Uric Acid | 2018 |
Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Apomorphine; Disease Models, Animal; Hyperuricemia; Male; Mental Disorders; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Oxonic Acid; Parkinson Disease, Secondary; Rotarod Performance Test; Tyrosine 3-Monooxygenase; Uric Acid | 2019 |
Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
Topics: Administration, Oral; Animals; Aorta; C-Reactive Protein; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Hyperuricemia; Intercellular Adhesion Molecule-1; Mangifera; Nitric Oxide; Nitric Oxide Synthase Type III; Oxonic Acid; Phytotherapy; Plant Leaves; Rats, Sprague-Dawley; Systole; Uric Acid; Xanthones | 2018 |
Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage.
Topics: Animals; Cytoprotection; Dietary Supplements; Dose-Response Relationship, Drug; Hyperuricemia; Kidney; Male; Oxidative Stress; Oxonic Acid; Pilot Projects; Probiotics; Rats; Rats, Wistar; Uric Acid | 2018 |
Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice.
Topics: Animals; Creatinine; Disease Models, Animal; Fruit; Gene Expression Regulation; Hyperuricemia; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Rosaceae; Uric Acid; Xanthine Oxidase | 2018 |
Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate.
Topics: Acute Kidney Injury; Allopurinol; Animals; Disease Models, Animal; Disease Progression; Glycerol; Heat-Shock Response; Hot Temperature; Humans; Kidney; Male; Occupational Exposure; Oxidative Stress; Oxonic Acid; Rats; Renal Insufficiency, Chronic; Rhabdomyolysis; Sodium Bicarbonate; Treatment Outcome; Urate Oxidase; Uric Acid | 2018 |
Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies.
Topics: Animals; Antiporters; Cell Line; Humans; Hyperuricemia; Hypoglycemic Agents; Kidney; Liver; Male; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Oxonic Acid; Rats, Wistar; Recombinant Proteins; Tissue Distribution; Uric Acid | 2019 |
A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.
Topics: Allopurinol; Animals; Anserine; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Hyperuricemia; Larva; Oxonic Acid; Uric Acid; Xanthine; Zebrafish | 2019 |
New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats.
Topics: Animals; Humans; Hyperuricemia; Liver; Male; Oryza; Oxonic Acid; Peptides; Plant Extracts; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2019 |
Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.
Topics: Animals; Creatinine; Down-Regulation; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Humans; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred ICR; Organic Anion Transporters; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2019 |
Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice.
Topics: Animals; Creatinine; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Male; Mice; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Protective Agents; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2019 |
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
Topics: Adenine; Animals; Antiporters; Cephalexin; Creatinine; Disease Models, Animal; Down-Regulation; Humans; Hyperuricemia; Kidney; Male; Metformin; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Pharmacokinetics; Rats; Rats, Wistar; RNA, Messenger; Uric Acid | 2019 |
Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.
Topics: Animals; Antioxidants; Arthritis, Gouty; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Flavonols; Glycosides; Gout; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice, Inbred BALB C; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Smilax; Tandem Mass Spectrometry; Uric Acid | 2019 |
Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Discriminant Analysis; Hyperuricemia; Least-Squares Analysis; Lipid Metabolism; Lipids; Male; Mass Spectrometry; Metabolic Networks and Pathways; Metabolome; Metabolomics; Multivariate Analysis; Oxonic Acid; Principal Component Analysis; Rats, Sprague-Dawley; Uric Acid | 2019 |
Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.
Topics: Anacardiaceae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chalcone; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Flavanones; Hyperuricemia; Inflammation; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oxonic Acid; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2019 |
Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.
Topics: Alpinia; Animals; China; Gout; Humans; Hyperuricemia; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Rats; Republic of Korea; Uric Acid; Xanthine Oxidase | 2019 |
MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Topics: Animals; Base Sequence; Case-Control Studies; Chemokine CCL2; Disease Models, Animal; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Humans; Hyperuricemia; Hypoxanthine; Inflammation; Interleukin-1beta; Kidney Cortex; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Oligonucleotide Array Sequence Analysis; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Renal Reabsorption; Signal Transduction; Uric Acid | 2019 |
Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis.
Topics: Administration, Oral; Allopurinol; Animals; Chemical Precipitation; Chitosan; Disease Models, Animal; Drug Delivery Systems; Kidney; Magnetite Nanoparticles; Mice; Nanoparticles; Nephrolithiasis; Oxonic Acid; Uric Acid | 2019 |
Comprehensive analysis of mechanism underlying hypouricemic effect of glucosyl hesperidin.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Glucose Transport Proteins, Facilitative; Glucosides; Hesperidin; Hyperuricemia; Intestine, Small; Kidney; Liver; Male; Mice, Inbred C57BL; Organic Anion Transporters; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2020 |
Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice.
Topics: Animals; Creatinine; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transporters; Orthosiphon; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2020 |
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Topics: Animals; Benzimidazoles; Benzoxazoles; Cell Line; Disease Models, Animal; Gout; Humans; Hyperuricemia; Interleukin-1beta; Liver; Mice; Monocytes; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Rats; Structure-Activity Relationship; Synovial Membrane; Uric Acid; Xanthine Oxidase | 2020 |
ABCG2 expression and uric acid metabolism of the intestine in hyperuricemia model rat.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Hyperuricemia; Intestines; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Dehydrogenase | 2020 |
Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat's model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Drug Development; Gout Suppressants; Hyperuricemia; Male; Oxonic Acid; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Uric Acid | 2020 |
Uricostatic and uricosuric effect of grapefruit juice in potassium oxonate-induced hyperuricemic mice.
Topics: Animals; Citrus paradisi; Hyperuricemia; Mice; Oxonic Acid; Uric Acid | 2020 |
NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Glucosides; Humans; Hyperuricemia; Kidney; Male; Metabolomics; Oxonic Acid; Rats; Rats, Sprague-Dawley; Stilbenes; Uric Acid | 2020 |
The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Chromatography, High Pressure Liquid; Creatinine; Disease Models, Animal; Glucose Transport Proteins, Facilitative; Hyperuricemia; Kidney; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Sodium-Phosphate Cotransporter Proteins, Type I; Time Factors; Uric Acid | 2020 |
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Topics: Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibitors; Flavanones; Glucose Transport Proteins, Facilitative; HEK293 Cells; Humans; Hyperuricemia; Kidney; Liver; Male; Mice; Molecular Docking Simulation; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2021 |
Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance.
Topics: Animals; Antioxidants; Biomarkers; Chronic Disease; Creatinine; Disease Models, Animal; Hyperuricemia; Kidney; Lipid Peroxidation; Liver; Male; Oxonic Acid; Rats, Wistar; Urea; Uric Acid | 2021 |
Xanthine oxidase inhibitory activity and antihyperuricemic effect of Moringa oleifera Lam. leaf hydrolysate rich in phenolics and peptides.
Topics: Animals; Creatinine; Disease Models, Animal; Flavonoids; Gout Suppressants; Hyperuricemia; Malondialdehyde; Moringa oleifera; Organic Anion Transporters; Oxonic Acid; Peptides; Phenols; Plant Extracts; Plant Leaves; Rats; Triglycerides; Uric Acid; Xanthine Oxidase | 2021 |
Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats.
Topics: Adenosine Deaminase; Animals; Creatinine; Humans; Hyperuricemia; Kidney; Liver; Male; Oxonic Acid; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Uric Acid; Whey; Whey Proteins; Xanthine Oxidase | 2021 |
Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Creatinine; Cytokines; Disease Models, Animal; Disulfiram; Humans; Mice; Oxonic Acid; Pyroptosis; Uric Acid | 2022 |
Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.
Topics: Animals; Blood Urea Nitrogen; Chlorogenic Acid; Creatinine; Dietary Supplements; Gastrointestinal Microbiome; Homeostasis; Hyperuricemia; Hypoxanthine; Inflammation; Interleukin-1beta; Intestines; Kidney; Lipopolysaccharides; Male; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Oxonic Acid; Signal Transduction; Toll-Like Receptor 4; Uric Acid; Xanthine Oxidase | 2021 |
Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway.
Topics: Animals; Apigenin; beta Catenin; Creatinine; Dose-Response Relationship, Drug; Fibrosis; Glucose Transport Proteins, Facilitative; HEK293 Cells; Humans; Hyperuricemia; Kidney Diseases; Male; Mice; Nephritis; Organic Anion Transporters; Oxonic Acid; Uric Acid; Wnt Signaling Pathway | 2021 |
Effects of Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Fructose and Potassium Oxonate.
Topics: Adenosine Triphosphate; Animals; Dendrobium; Fructose; Hyperuricemia; Kidney; Oxonic Acid; Plant Extracts; Plant Leaves; Rats; Uric Acid; Xanthine Oxidase | 2022 |
Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat.
Topics: Animals; Creatinine; Hyperuricemia; Lipid Metabolism; Lipidomics; Oxonic Acid; Psyllium; Rats, Sprague-Dawley; Triglycerides; Tumor Necrosis Factor-alpha; Uric Acid | 2021 |
Topics: Acute Kidney Injury; Animals; Animals, Outbred Strains; Carrier Proteins; Cytokines; Dietary Supplements; Fatty Acids; Hyperuricemia; Hypoxanthine; Kelch-Like ECH-Associated Protein 1; Kidney; Lythraceae; Male; Mice; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Organic Anion Transporters; Oxidative Stress; Oxonic Acid; Plant Oils; Reactive Oxygen Species; Seeds; Signal Transduction; Thioredoxins; Uric Acid | 2021 |
Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice.
Topics: Animals; Arthritis, Gouty; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2021 |
Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats.
Topics: Animals; Egg Shell; Humans; Hyperuricemia; Inflammation; Injections; Kidney; Kidney Function Tests; Male; Oocytes; Organic Anion Transporters; Oxonic Acid; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase; Xenopus | 2021 |
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Berberine; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Cytokines; Disease Models, Animal; Glucose Transport Proteins, Facilitative; Hyperuricemia; Hypoxanthine; Janus Kinase 2; Kidney Diseases; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Protective Agents; Signal Transduction; STAT3 Transcription Factor; Uric Acid; Xanthine Oxidase | 2021 |
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Topics: Animals; Antioxidants; Hyperuricemia; Hypoxanthine; Inflammation; Kidney; Male; Mice; Mice, Inbred ICR; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Signal Transduction; Transcription Factor RelA; Uric Acid; Xanthine Oxidase; Xanthophylls | 2021 |
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
Topics: Animals; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hyperuricemia; Ligands; Models, Molecular; Molecular Structure; Oxonic Acid; Rats; Structure-Activity Relationship; Triazoles; Uric Acid; Xanthine Oxidase | 2022 |
Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro.
Topics: Alstonia; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Uric Acid | 2022 |
A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
Topics: Animals; Catalase; Creatinine; Cytokines; Flavonoids; Hyperuricemia; Inflammation; Kidney; Molecular Docking Simulation; Oxonic Acid; Plant Extracts; Rats; Superoxide Dismutase; Urea; Uric Acid; Xanthine Oxidase | 2022 |
Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3.
Topics: Animals; Caffeic Acids; Hyperuricemia; Kidney; Mice; Molecular Docking Simulation; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Phenylethyl Alcohol; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2022 |
Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia.
Topics: Animals; Antioxidants; Cornus; Gout; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2022 |
Autophagy-dependent Na
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Autophagy; Hydroxychloroquine; Hyperuricemia; Interleukin-1beta; Lysosomal Membrane Proteins; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sodium; Sodium-Potassium-Exchanging ATPase; Uric Acid | 2022 |
Hypouricemic effect of gallic acid, a bioactive compound from
Topics: Adenosine Deaminase; Adenosine Triphosphatases; Animals; Creatinine; Cyclooxygenase 2; Cystatins; Gallic Acid; Hyperuricemia; Interleukin-6; Kidney; Lythraceae; Mice; Oxonic Acid; Superoxide Dismutase; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Uric Acid; Water; Xanthine Oxidase | 2022 |
Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency.
Topics: Animals; Fibrosis; Hyperuricemia; Inflammation; Kidney; Kidney Diseases; Nephrectomy; Oxonic Acid; Rats; Renal Insufficiency; Renin; Uric Acid | 2023 |
Anti-Hyperuricemic, Nephroprotective, and Gut Microbiota Regulative Effects of Separated Hydrolysate of α-Lactalbumin on Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice.
Topics: Animals; Gastrointestinal Microbiome; Hyperuricemia; Hypoxanthines; Inflammation; Kidney; Lactalbumin; Mice; Oxonic Acid; Transcription Factors; Uric Acid | 2023 |
Oxyberberrubine, a novel liver microsomes-mediated secondary metabolite of berberine, alleviates hyperuricemic nephropathy in mice.
Topics: Animals; Berberine; Hyperuricemia; Kidney; Mice; Microsomes, Liver; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2023 |
The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of
Topics: Flavonoids; Hyperuricemia; Kidney; Molecular Docking Simulation; Moringa oleifera; Organic Anion Transporters; Oxonic Acid; Uric Acid | 2022 |
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Topics: Animals; Apigenin; Creatinine; Glucosides; Gout; Hyperuricemia; Kidney; Malondialdehyde; Mice; Molecular Docking Simulation; Organic Anion Transporters; Oxonic Acid; Paeonia; Superoxide Dismutase; Uric Acid; Xanthine Oxidase | 2023 |