uric acid has been researched along with methotrexate in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (54.72) | 18.7374 |
| 1990's | 7 (13.21) | 18.2507 |
| 2000's | 3 (5.66) | 29.6817 |
| 2010's | 6 (11.32) | 24.3611 |
| 2020's | 8 (15.09) | 2.80 |
| Authors | Studies |
|---|---|
| Endou, H; Hosoyamada, M; Kanai, Y; Sekine, T; Watanabe, N | 1 |
| Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T | 1 |
| Hori, S; Kikkawa, T; Mori, S; Ohtsuki, S; Otagiri, M; Takanaga, H; Terasaki, T | 1 |
| Garnick, MB; Mayer, RJ | 1 |
| Cadman, ED; Capizzi, RL; Finch, SC; Lundberg, WB | 1 |
| Senn, HJ | 1 |
| Mellor, D | 1 |
| Bertino, JR; Cadman, EC; Lunberg, WB | 1 |
| Henderson, GB; Tsuji, JM | 1 |
| Czyzewska, K; Knapowski, J | 1 |
| Henderson, GB | 1 |
| Blackwood, JM; Keller, JW; Pace, WG | 1 |
| Krakoff, IH | 1 |
| Burry, HC | 1 |
| Lampkin, B; Mauer, AM; McWilliams, NB | 1 |
| Alsarraf, D; Reese, L | 1 |
| Armata, J; Depowska, T | 1 |
| Armata, J | 1 |
| Dano, K; Nissen, NI | 1 |
| Hitchings, GH | 1 |
| Maher, JF; Rath, CE; Schreiner, GE | 1 |
| Bradford, LG; Noojin, RO; Osment, LS | 1 |
| Freireich, EJ | 1 |
| Gordon, M; Martin, JH; Wallace, R | 1 |
| Honig, G; Morgan, E; Nelson, DJ | 1 |
| Schilsky, RL | 1 |
| Calvert, AH; Dady, PJ; Harrap, KR; Muindi, JF; Smith, IE; Smyth, JF; Taylor, GA | 1 |
| Balow, JE; Cohen, LF; Magrath, IT; Poplack, DG; Ziegler, JL | 1 |
| Boss, GR; Frei, E; Herbst, K; Howell, SB | 1 |
| Brockerhoff, P; Casper, F; Hofmann, M; Mahlke, M | 1 |
| Arreguín, L; Benítez, H; Bernaldez, R; Díaz, S; Farfán, J; Gaona, A; Juan, L; Martínez, MC; Velásquez, L | 1 |
| Swierkot, J; Szechiński, J; Wiland, P | 1 |
| Evans, WE; Harrison, PL; Lascombes, F; Mahmoud, HH; Mondesir, JM; Pui, CH; Relling, MV; Ribeiro, RC; Rivera, GK; Sandlund, JT; Struxiano, A | 1 |
| Kaznowska, Z; Simmonds, HA; Smoleńska, Z; Smoleński, RT; Zarówny, D | 1 |
| MEYERS, MC; PENNER, JA; WEINTRAUB, LR | 1 |
| BALIS, ME; KRAKOFF, IH | 1 |
| SCHULMAN, MP; SNYDER, R; VOGEL, WH | 1 |
| Russel, FG; Smeets, PH; Van Aubel, RA; van den Heuvel, JJ | 1 |
| Crews, KR; Howard, SC; Jeha, S; Pauley, JL; Pui, CH; Relling, MV; Zhou, Y | 1 |
| Antonelli, A; Carpi, A; Cervetti, G; Fallahi, P; Franzoni, F; Galetta, F; Petrini, M; Regoli, F; Santoro, G; Tocchini, L | 1 |
| De Bona, KS; Funchal, C; Moretto, MB; Pimentel, VC; Pinheiro, FV; Salvador, M; Scola, G | 1 |
| Kanamitsu, K; Kusuhara, H; Schuetz, JD; Sugiyama, Y; Takeuchi, K | 1 |
| Asci, H; Aydin, B; Bas, E; Ellidag, HY; Ozmen, O; Yilmaz, N | 1 |
| Bessen, MY; Bessen, SY; Yung, CM | 1 |
| Bennett, R; Botson, JK; Kenney, HM; LaMoreaux, B; Obermeyer, K; Peloso, PM; Peterson, J; Tesser, JRP; Weinblatt, ME | 1 |
| Botson, JK; Peterson, J | 1 |
| Ashizawa, M; Ban, T; Fujiwara, SI; Hatano, K; Ikeda, T; Ito, S; Kanda, Y; Kawaguchi, S; Matsuoka, S; Minakata, D; Murahashi, R; Nagayama, T; Nakano, H; Nakashima, H; Oh, I; Ohmine, K; Sato, K; Toda, Y; Umino, K; Yamamoto, C; Yamasaki, R | 1 |
| Becce, F; Botson, JK; Dalbeth, N; Kumar, A; Zhao, L | 1 |
| Bennett, R; Botson, JK; Chamberlain, J; Kenney, HM; LaMoreaux, B; Obermeyer, K; Peloso, PM; Peterson, J; Ramanathan, S; Song, Y; Tesser, JRP; Weinblatt, ME; Xin, Y; Zhao, L | 1 |
| Botson, JK; Chamberlain, J; Grewal, S; La, D; LaMoreaux, B; LoCicero, K; Majjhoo, A; Obermeyer, K; Ong, S; Parikh, N; Peterson, J; Saag, K; Sainati, S; Tesser, JRP; Verma, S; Weinblatt, ME; Xin, Y | 1 |
| Botson, JK; LaMoreaux, B; Obermeyer, K; Peterson, J; Weinblatt, ME; Zhao, L | 1 |
| Iqbal, MA; Mumtaz, T; Tahir, A; Tariq, MA | 1 |
6 review(s) available for uric acid and methotrexate
| Article | Year |
|---|---|
Encephalitis and encephalopathy in childhood leukaemia.
Topics: Antineoplastic Agents; Asparaginase; Brain Diseases; Brain Neoplasms; Child; Encephalitis; Humans; Leukemia; Metabolic Diseases; Methotrexate; Radiotherapy; Toxoplasmosis; Uric Acid; Vincristine; Virus Diseases | 1976 |
Treatment of acute leukemia.
Topics: Asparaginase; Bacterial Infections; Central Nervous System Diseases; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Synergism; Hemorrhage; Humans; Immunotherapy; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Mitosis; Neoplasms, Nerve Tissue; Prednisone; Remission, Spontaneous; Testicular Neoplasms; Uric Acid; Vincristine | 1972 |
[Danger of hyperuricemia in the treatment of acute leukemia, lymphosarcoma and reticulosarcoma].
Topics: Acute Disease; Allopurinol; Antineoplastic Agents; Child; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Prednisone; Uric Acid; Xanthine Oxidase | 1974 |
[New principles of treatment in acute leukemia].
Topics: Adolescent; Adult; Antineoplastic Agents; Central Nervous System Diseases; Child; Cyclophosphamide; Cytarabine; Female; Guanidines; Humans; Hydroxyurea; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Leukopenia; Male; Mercaptopurine; Methotrexate; Middle Aged; Nitroso Compounds; Prednisone; Thrombocytopenia; Urea; Uric Acid; Vincristine | 1970 |
Chemotherapy and comparative biochemistry: G. H. A. Clowes memorial lecture.
Topics: Allopurinol; Animals; Antimetabolites; Azathioprine; Binding Sites; Drug Therapy; Enzyme Inhibitors; Enzyme Precursors; Folic Acid; Folic Acid Antagonists; Humans; Lactobacillus; Leukemia, Myeloid; Liver; Mercaptopurine; Methotrexate; Mice; Molecular Weight; Neoplasms; Nucleic Acids; Proteus; Purines; Research; Species Specificity; Thymine; Transferases; Uric Acid; Xanthine Oxidase | 1969 |
Recapture and improved outcome of pegloticase response with methotrexate-A report of two cases and review of the literature.
Topics: Adult; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Treatment Outcome; Urate Oxidase; Uric Acid | 2019 |
5 trial(s) available for uric acid and methotrexate
| Article | Year |
|---|---|
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies.
Topics: Allopurinol; Antimetabolites; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Urate Oxidase; Uric Acid | 1997 |
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.
Topics: Adenosine; Adenosine Triphosphate; Adult; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Chronic Disease; Cytidine Triphosphate; Erythrocytes; Female; Guanosine Triphosphate; Humans; Hypoxanthine; Methotrexate; Middle Aged; Ribonucleotides; Uric Acid; Uridine | 1999 |
In vitro and in vivo study on the antioxidant activity of dexrazoxane.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Bleomycin; Chromans; Cyclophosphamide; Cytarabine; Epirubicin; Etoposide; Female; Free Radical Scavengers; Glutathione; Humans; Lymphoma, Non-Hodgkin; Male; Methotrexate; Middle Aged; Prednisone; Razoxane; Time Factors; Uric Acid; Vincristine | 2010 |
Pegloticase in Combination With Methotrexate in Patients With Uncontrolled Gout: A Multicenter, Open-label Study (MIRROR).
Topics: Adult; Gout; Gout Suppressants; Humans; Male; Methotrexate; Middle Aged; Polyethylene Glycols; Treatment Outcome; Urate Oxidase; Uric Acid | 2021 |
A Randomized, Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled Gout Receiving Pegloticase: Primary Efficacy and Safety Findings.
Topics: Adult; Anaphylaxis; Arthritis, Gouty; Double-Blind Method; Gout; Gout Suppressants; Humans; Methotrexate; Polyethylene Glycols; Symptom Flare Up; Treatment Outcome; Uric Acid | 2023 |
42 other study(ies) available for uric acid and methotrexate
| Article | Year |
|---|---|
Expression cloning and characterization of a novel multispecific organic anion transporter.
Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Carrier Proteins; Cloning, Molecular; Dicarboxylic Acid Transporters; Gene Expression; Glycosylation; In Situ Hybridization; Kidney; Kinetics; Membrane Proteins; Molecular Sequence Data; Organic Anion Transporters, Sodium-Dependent; p-Aminohippuric Acid; Rats; RNA, Messenger; Symporters; Xenopus laevis | 1997 |
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis | 2001 |
Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Estrone; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Osteosclerosis; Penicillin G; RNA, Messenger | 2004 |
Acute renal failure associated with neoplastic disease and its treatment.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Female; Humans; Hypercalcemia; Kidney; Methotrexate; Multiple Myeloma; Myeloma Proteins; Neoplasm Invasiveness; Neoplasms; Radiation Injuries; Streptozocin; Ureteral Obstruction; Uric Acid; Urogenital Neoplasms | 1978 |
Renal failure secondary to leukemic infiltration of the kidneys.
Topics: Calcium; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Neoplasms; Leukemia, Lymphoid; Methotrexate; Middle Aged; Neoplasm Metastasis; Phosphates; Radiotherapy Dosage; Uric Acid; Urography | 1977 |
[Treatment-induced complications and frequent errors in cytostatic therapy].
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Hypercalcemia; Male; Methotrexate; Middle Aged; Neoplasms; Uric Acid; Vincristine | 1978 |
Hyperphosphatermia and hypocalcemia accompanying rapid cell lysis in a patient with Burkitt's lymphoma and Burkitt cell leukemia.
Topics: Acute Kidney Injury; Adult; Burkitt Lymphoma; Cyclophosphamide; Head and Neck Neoplasms; Hemolysis; Humans; Hypocalcemia; Leukemia; Male; Methotrexate; Phosphorus; Uric Acid | 1977 |
Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cholic Acids; Cytochalasin B; Folic Acid; Glucose; Leukemia L1210; Methotrexate; Mice; Probenecid; Substrate Specificity; Sulfobromophthalein; Temperature; Tumor Cells, Cultured; Uric Acid; Vincristine | 1990 |
Permeability of peritoneal membrane "in vitro" under the effect of methotrexate.
Topics: Albumins; Animals; Biological Transport; In Vitro Techniques; Inulin; Methotrexate; Peritoneal Cavity; Rabbits; Urea; Uric Acid | 1989 |
Mediation of cellular anion detoxification in leukemic cells by unidirectional efflux pumps.
Topics: Animals; Anions; Biological Transport; Cholic Acids; Cyclic AMP; Drug Resistance; Folic Acid; Leukemia L1210; Methotrexate; Tumor Cells, Cultured; Uric Acid | 1989 |
Uric acid excretion following pelvic perfusion for malignancy.
Topics: Chemotherapy, Cancer, Regional Perfusion; Fluorouracil; Humans; Melphalan; Methotrexate; Palliative Care; Pelvic Neoplasms; Tourniquets; Uric Acid | 1967 |
Increase in uric acid biosynthesis produced by 2-substituted thiadiazoles.
Topics: Azaserine; Azoles; Diazooxonorleucine; Mercaptopurine; Methotrexate; Niacinamide; Nicotinic Acids; Tryptophan; Uric Acid | 1965 |
Monilial septicaemia in acute leukaemia. Successful treatment in a case complicated by acute uric acid nephropathy.
Topics: Acetazolamide; Adolescent; Amphotericin B; Candidiasis; Humans; Infectious Mononucleosis; Kidney Diseases; Leukemia; Male; Mercaptopurine; Methotrexate; Nystatin; Penicillins; Peripheral Nervous System Diseases; Prednisone; Rolitetracycline; Sepsis; Uric Acid | 1966 |
Management of acute renal failure due to marked hyperuricemia.
Topics: Acute Kidney Injury; Adolescent; Allopurinol; Bicarbonates; Humans; Infusions, Parenteral; Kidney; Leukemia, Lymphoid; Male; Methotrexate; Potassium; Prednisone; Radiography; Regional Blood Flow; Renal Dialysis; Sodium; Thrombocytopenia; Uric Acid; Vincristine | 1972 |
[Hypocalcemia and hyperuricemia during treatment of acute lymphoblastic leukemia in childhood].
Topics: Acute Disease; Allopurinol; Child, Preschool; Humans; Hyperkalemia; Hypocalcemia; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Uric Acid | 1974 |
Methrotrexate U.S.P. (amethopterin) and methotrexate sodium.
Topics: Abortion, Induced; Anemia; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Choriocarcinoma; Drug Interactions; Female; Humans; Leukemia; Leukopenia; Male; Methotrexate; Neoplasms; Pregnancy; Psoriasis; Skin Diseases; Testicular Neoplasms; Thrombocytopenia; Uric Acid; Uterine Neoplasms | 1973 |
Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis.
Topics: Acetazolamide; Acute Kidney Injury; Adult; Allopurinol; Anuria; Bicarbonates; Blood Gas Analysis; Blood Urea Nitrogen; Carbon Dioxide; Cystoscopy; Electroencephalography; Eye Manifestations; Female; Humans; Leukemia, Lymphoid; Leukocytosis; Mannitol; Mercaptopurine; Methotrexate; Peritoneal Dialysis; Prednisone; Splenomegaly; Thrombocytopenia; Uric Acid; Urinary Catheterization; Vincristine; Water-Electrolyte Balance | 1969 |
Monitoring methotrexate therapy in psoriasis.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Proteins; Child; Cholesterol; Female; Humans; L-Lactate Dehydrogenase; Liver; Male; Methotrexate; Middle Aged; Psoriasis; Uric Acid | 1970 |
The management of acute leukemia.
Topics: Adult; Anti-Bacterial Agents; Child; Cyclophosphamide; Hemorrhage; Humans; Infections; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisone; Prognosis; Uric Acid; Vincristine | 1967 |
Methotrexate in psoriasis. Precipitation of gout.
Topics: Colchicine; Female; Gout; Humans; Injections, Intravenous; Male; Methotrexate; Middle Aged; Psoriasis; Uric Acid | 1967 |
Acute lymphocytic leukemia in a child with congenital xanthine oxidase deficiency: implications for therapy.
Topics: Adolescent; Allopurinol; Asparaginase; Female; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Thioinosine; Uric Acid; Vincristine; Xanthine Oxidase | 1981 |
Renal and metabolic toxicities of cancer chemotherapy.
Topics: Antineoplastic Agents; Cisplatin; Drug Administration Schedule; Electrolytes; Glomerular Filtration Rate; Humans; Kidney Diseases; Methotrexate; Neoplasms; Nitrosourea Compounds; Nucleic Acids; Uric Acid | 1982 |
Methotrexate with thymidine, inosine, and allopurinol rescue: a phase I clinical study.
Topics: Adult; Aged; Allopurinol; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypoxanthines; Infusions, Parenteral; Inosine; Male; Methotrexate; Middle Aged; Thymidine; Uric Acid | 1981 |
Acute tumor lysis syndrome. A review of 37 patients with Burkitt's lymphoma.
Topics: Adolescent; Adult; Antineoplastic Agents; Burkitt Lymphoma; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Humans; Hyperkalemia; Hypocalcemia; Methotrexate; Phosphorus Metabolism Disorders; Prednisone; Syndrome; Thioguanine; Uremia; Uric Acid; Vincristine | 1980 |
Thymidine requirements for the rescue of patients treated with high-dose methotrexate.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Methotrexate; Thymidine; Uric Acid | 1980 |
[Persistent granulocytosis and hyperuricemia after a single G-CSF injection (Filgrastim) in treatment of chemotherapy-induced myelosuppression in metastatic breast carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Filgrastim; Fluorouracil; Granulocyte Colony-Stimulating Factor; Granulocytes; Humans; Injections, Subcutaneous; Leukocyte Count; Methotrexate; Radiotherapy, Adjuvant; Recombinant Proteins; Uric Acid | 1995 |
[Electrolytic changes in children with acute lymphoblastic leukemia during remission induction].
Topics: Adolescent; Allopurinol; Anions; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Blood Urea Nitrogen; Cations; Child; Child, Preschool; Cohort Studies; Creatinine; Epirubicin; Female; Humans; Hydrocortisone; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Serum Albumin; Uric Acid; Vincristine; Water-Electrolyte Imbalance | 1995 |
N-acetyl-beta-D-glucosaminidase urinary excretion as an early indicator of kidney dysfunction in rheumatoid arthritis patients on low-dose methotrexate treatment.
Topics: Acetylglucosaminidase; Adult; Aged; Albuminuria; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Female; Humans; Kidney Diseases; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Uric Acid | 1997 |
ACUTE URIC ACID NEPHROPATHY IN LEUKEMIA. REPORT OF A CASE TREATED WITH PERITONEAL DIALYSIS.
Topics: Acute Kidney Injury; Adolescent; Blood; Dialysis; Humans; Kidney Diseases; Leukemia; Mercaptopurine; Metabolism; Methotrexate; Peritoneal Dialysis; Renal Dialysis; Renal Insufficiency; Toxicology; Uric Acid; Urine | 1964 |
ABNORMALITIES OF PURINE METABOLISM IN HUMAN LEUKEMIA.
Topics: Blood; Carbon Isotopes; Formates; Geriatrics; Humans; Leukemia; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Metabolism; Methotrexate; Nucleic Acids; Uric Acid; Urine | 1964 |
INHIBITION OF SEVERAL ENZYMES BY FOLIC ACID, AMINOPTERIN AND AMETHOPTERIN.
Topics: Amino Acid Oxidoreductases; Aminopterin; Carbonic Anhydrases; Carboxy-Lyases; Carboxypeptidases; Catalase; D-Amino-Acid Oxidase; Enzyme Inhibitors; Folic Acid; Hexokinase; Lysine; Methotrexate; Oxidoreductases; Peroxidases; Research; Uric Acid | 1964 |
Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.
Topics: Adenosine Triphosphate; Animals; Antimetabolites, Antineoplastic; Cell Culture Techniques; Cyclic AMP; Cyclic GMP; Humans; Kidney; Liver; Membrane Transport Proteins; Methotrexate; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Ribosomal Proteins; Spodoptera; Uric Acid | 2005 |
Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia.
Topics: Allopurinol; Child; Child, Preschool; Female; Humans; Hyperuricemia; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Urate Oxidase; Uric Acid | 2010 |
Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract.
Topics: Adenosine Deaminase; Alanine Transaminase; Animals; Grape Seed Extract; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Methotrexate; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Uric Acid | 2010 |
Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
Topics: 2,4-Dichlorophenoxyacetic Acid; Acridines; Adenosine Triphosphate; Animals; Biological Transport; Blood-Brain Barrier; Brain; Central Nervous System; Cyclic GMP; Humans; Kinetics; Male; Methotrexate; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Ochratoxins; Pravastatin; Quinazolines; Quinolines; Tetrahydroisoquinolines; Thiophenes; Uric Acid | 2017 |
The impact of gallic acid on the methotrexate-induced kidney damage in rats.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Blood Urea Nitrogen; Creatinine; Gallic Acid; Humans; Kidney; Kidney Diseases; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Uric Acid | 2017 |
Pretreatment and Coadministration With Methotrexate Improved Durability of Pegloticase Response: An Observational, Proof-of-Concept Case Series.
Topics: Gout; Gout Suppressants; Humans; Methotrexate; Polyethylene Glycols; Treatment Outcome; Urate Oxidase; Uric Acid | 2022 |
Risk factors for high-dose methotrexate-induced nephrotoxicity.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Female; Hematologic Neoplasms; Humans; Kidney Diseases; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors; Uric Acid; Young Adult | 2021 |
Dual-energy CT assessment of rapid monosodium urate depletion and bone erosion remodelling during pegloticase plus methotrexate co-therapy.
Topics: Adult; Arthritis, Gouty; Gout; Humans; Male; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Uric Acid | 2022 |
A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an
Topics: Gout; Gout Suppressants; Humans; Male; Methotrexate; Polyethylene Glycols; Symptom Flare Up; Treatment Outcome; Urate Oxidase; Uric Acid | 2022 |
Improved joint and patient-reported health assessments with pegloticase plus methotrexate co-therapy in patients with uncontrolled gout: 12-month exploratory outcomes of the MIRROR open-label trial.
Topics: Adult; Gout; Gout Suppressants; Humans; Methotrexate; Polyethylene Glycols; Quality of Life; Treatment Outcome; Urate Oxidase; Uric Acid | 2022 |
Comparative analysis of multiorgan toxicity induced by long term use of disease modifying anti-rheumatic drugs.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Creatinine; Humans; Leflunomide; Methotrexate; Renal Insufficiency; Urea; Uric Acid | 2023 |