uric acid has been researched along with lesinurad in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 27 (93.10) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Baumgartner, S; Fleischmann, R; Hingorani, V; Kerr, B; Manhard, K; Miner, JN; Polvent, E; Quart, B; Shen, Z; Suster, M; Yeh, LT | 1 |
| Hingorani, V; Kerr, B; Manhard, K; Quart, B; Rowlings, C; Shen, Z; Storgard, C; Yeh, LT | 1 |
| Gillen, M; Kerr, B; Shen, Z; Wallach, K; Yeh, LT; Zhu, N | 1 |
| Girardet, JL; Hagerty, DT; Hyndman, D; Iverson, C; Liu, S; Manhard, K; Miner, JN; Nanavati, P; Quart, B; Shen, Z; Tan, PK; Terkeltaub, R; Yeh, LT | 1 |
| Adler, S; Bardin, T; Baumgartner, S; Bhakta, N; Fung, M; Keenan, RT; Khanna, PP; Kopicko, J; So, A; Storgard, C | 1 |
| Gillen, M; Harmon, E; Kerr, B; Lee, CA; Nguyen, M; Shen, Z; Tieu, K; Wilson, DM | 1 |
| Gillen, M; Kerr, B; Lee, CA; Shen, Z; Valdez, S; Zhou, D | 1 |
| Deeks, ED | 1 |
| Adler, S; Baumgartner, S; Bhakta, N; Dalbeth, N; Fung, M; Jones, G; Khanna, D; Kopicko, J; Perez-Ruiz, F; Storgard, C; Terkeltaub, R | 1 |
| Hill-McManus, D; Hughes, D; Lane, S; Marshall, S; Soto, E | 2 |
| Day, R; Jones, G; Panova, E | 1 |
| Abhishek, A | 1 |
| Cai, W; Liu, W; Liu, Y; Tang, L; Wang, J; Wu, J; Xie, Y; Xu, W; Zhang, S; Zhao, G | 1 |
| Aksenov, S; Eriksson, UG; Peck, CC; Stanski, DR | 1 |
| Kuehn, BM | 1 |
| Baumgartner, S; Kerr, B; Manhard, K; Quart, B; Shen, Z; Yeh, LT | 1 |
| Chen, R; Du, Z; Jia, Z; Liu, J; Sun, J; Wang, K; Xin, Y; Xu, Q; Xu, T; Zhang, C | 1 |
| Gillen, M; Hall, J; Ito, Y; Liu, S; Shen, Z; Shiramoto, M; Yamamoto, A; Yan, X | 1 |
| Gillen, M; Hall, J; Kerr, BM; Lee, CA; Shah, V; Shen, Z; Tieu, K; Wilson, DM; Yang, C | 1 |
| Baumgartner, S; Goldfarb, DS; Jalal, D; Pillinger, M; Saag, KG; Schechter, BM; Terkeltaub, R; Valiyil, R; White, WB | 1 |
| Robinson, PC | 1 |
| Girardet, JL; Lee, CA; Miner, JN; Renner, M; Shen, Z; Wilson, DM; Yang, C; Zhou, D | 1 |
| Fields, TR | 1 |
| Bartsch, LA; Castillo-Rodriguez, E; Fernandez-Prado, R; Kanbay, M; Ortiz, A; Perez-Gomez, MV | 1 |
| Gupta, MK; Singh, JA | 1 |
| Lee, YH; Song, GG | 1 |
| Alghamdi, YS; Nassan, MA; Soliman, MM | 1 |
| Dong, Y; Gao, S; Liang, R; Liao, H; Liu, X; Pang, J; Qi, D; Shi, X; Wu, T; Zhan, P; Zhang, J; Zhang, X; Zhang, Z; Zhao, T | 1 |
8 review(s) available for uric acid and lesinurad
| Article | Year |
|---|---|
Lesinurad: A Review in Hyperuricaemia of Gout.
Topics: Adult; Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Febuxostat; Gout; Humans; Hyperuricemia; Kidney; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2017 |
Guideline development for the management of gout: role of combination therapy with a focus on lesinurad.
Topics: Dose-Response Relationship, Drug; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Patient Selection; Practice Guidelines as Topic; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2017 |
New urate-lowing therapies.
Topics: Acetamides; Drug Interactions; Enzyme Inhibitors; Gout; Gout Suppressants; Humans; Phenylacetates; Probenecid; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Gout - An update of aetiology, genetics, co-morbidities and management.
Topics: Allopurinol; Chronic Disease; Comorbidity; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thioglycolates; Triazoles; Uric Acid | 2018 |
The Challenges of Approaching and Managing Gout.
Topics: Acetamides; Allopurinol; Antibodies, Monoclonal, Humanized; Colchicine; Diet Therapy; Febuxostat; Gout; Gout Suppressants; Humans; Medication Adherence; Patient Education as Topic; Phenylacetates; Polyethylene Glycols; Quality of Health Care; Rheumatology; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid | 2019 |
Potential Dangers of Serum Urate-Lowering Therapy.
Topics: Cardiovascular Diseases; Gout Suppressants; Humans; Oxidative Stress; Polyethylene Glycols; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2019 |
Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy.
Topics: Allopurinol; Anti-Inflammatory Agents; Cardiovascular Diseases; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid | 2019 |
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
.
Topics: Bayes Theorem; Drug Therapy, Combination; Gout; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2019 |
10 trial(s) available for uric acid and lesinurad
| Article | Year |
|---|---|
Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia.
Topics: Adult; Aged; Colchicine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Thioglycolates; Triazoles; Uric Acid | 2014 |
Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Capsules; Cross-Over Studies; Double-Blind Method; Gastrointestinal Absorption; Healthy Volunteers; Humans; Male; Organic Anion Transporters; Organic Cation Transport Proteins; Pharmaceutical Solutions; Renal Elimination; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2015 |
Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.
Topics: Cell Line; Gout; Humans; Kidney; Male; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2016 |
Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Creatinine; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency; Retreatment; Symptom Flare Up; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2017 |
Effects of renal function on pharmacokinetics and pharmacodynamics of lesinurad in adult volunteers.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Biological Availability; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Renal Elimination; Severity of Illness Index; Thioglycolates; Triazoles; Uric Acid | 2016 |
Lesinurad, a Selective Uric Acid Reabsorption Inhibitor, in Combination With Febuxostat in Patients With Tophaceous Gout: Findings of a Phase III Clinical Trial.
Topics: Creatinine; Double-Blind Method; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid | 2017 |
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout.
Topics: Adult; Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; Uric Acid | 2018 |
Verinurad combined with febuxostat in Japanese adults with gout or asymptomatic hyperuricaemia: a phase 2a, open-label study.
Topics: Administration, Oral; Adult; Aged; Benzbromarone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Time Factors; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2018 |
Metabolism and disposition of lesinurad, a uric acid reabsorption inhibitor, in humans.
Topics: Adult; Biological Availability; Cytochrome P-450 CYP2C9; Humans; Infusions, Intravenous; Male; Renal Elimination; Thioglycolates; Triazoles; Uric Acid | 2019 |
Characterization of Stereoselective Metabolism, Inhibitory Effect on Uric Acid Uptake Transporters, and Pharmacokinetics of Lesinurad Atropisomers.
Topics: Administration, Oral; Adult; Gout; Healthy Volunteers; HEK293 Cells; Humans; Kidney; Male; Microsomes, Liver; Middle Aged; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Renal Reabsorption; Stereoisomerism; Structure-Activity Relationship; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2019 |
11 other study(ies) available for uric acid and lesinurad
| Article | Year |
|---|---|
In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters.
Topics: Adolescent; Adult; Aged; Atorvastatin; Carrier Proteins; Cell Line; Diuretics; Drug Interactions; Furosemide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kidney; Liver; Liver-Specific Organic Anion Transporter 1; Male; Metformin; Middle Aged; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2016 |
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.
Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Europe; Female; Heart Rate; Humans; Male; Statistics as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2016 |
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout.
Topics: Computer Simulation; Drug Therapy, Combination; Febuxostat; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Models, Biological; Risk Assessment; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase | 2018 |
Systematic Structure-Activity Relationship (SAR) Exploration of Diarylmethane Backbone and Discovery of A Highly Potent Novel Uric Acid Transporter 1 (URAT1) Inhibitor.
Topics: Benzbromarone; Biological Transport, Active; Carbon Radioisotopes; Drug Design; Gene Expression; HEK293 Cells; Humans; Methane; Organic Anion Transporters; Organic Cation Transport Proteins; Structure-Activity Relationship; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics.
Topics: Allopurinol; Clinical Trials as Topic; Febuxostat; Humans; Hyperuricemia; Models, Theoretical; Precision Medicine; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Chronic Disease Approaches Needed to Curb Gout's Growing Burden.
Topics: Allopurinol; Chronic Disease; Diet; Drug Combinations; Febuxostat; Gout; Gout Suppressants; Healthy Lifestyle; Humans; Patient Education as Topic; Practice Guidelines as Topic; Purines; Thioglycolates; Triazoles; Uric Acid | 2018 |
Zurampic Protects Pancreatic β-Cells from High Uric Acid Induced-Damage by Inhibiting URAT1 and Inactivating the ROS/AMPK/ERK Pathways.
Topics: AMP-Activated Protein Kinases; Animals; Anion Transport Proteins; Extracellular Signal-Regulated MAP Kinases; Insulin-Secreting Cells; MAP Kinase Signaling System; Rats; Reactive Oxygen Species; Thioglycolates; Triazoles; Uric Acid | 2018 |
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Middle Aged; Randomized Controlled Trials as Topic; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase; Young Adult | 2019 |
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model.
Topics: Allopurinol; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Economics, Pharmaceutical; Febuxostat; Gout; Gout Suppressants; Health Care Costs; Humans; Medication Adherence; Models, Biological; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Thioglycolates; Treatment Outcome; Triazoles; United Kingdom; Uric Acid | 2018 |
Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Catalase; Drug Synergism; Glutathione Peroxidase; Gout Suppressants; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2020 |
Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.
Topics: Animals; Gout; Humans; Hyperuricemia; Mice; Organic Anion Transporters; Organic Cation Transport Proteins; Prospective Studies; Pyridines; Uric Acid | 2022 |