uric acid has been researched along with allopurinol in 2348 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 934 (39.78) | 18.7374 |
| 1990's | 233 (9.92) | 18.2507 |
| 2000's | 302 (12.86) | 29.6817 |
| 2010's | 609 (25.94) | 24.3611 |
| 2020's | 270 (11.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bergmann, F; Levene, L | 1 |
| Neto, M; Pilloff, B; Simon, J | 1 |
| Hardy, B; Klein, LA | 1 |
| Musil, J | 1 |
| Mertz, DP | 15 |
| Smith, I; Thomson, WH | 1 |
| de Vries, A; Sperling, O | 2 |
| Fuchs, D; Hermann, J; Plenert, W; Zintl, F | 1 |
| Bick, C; Brien, G; Gremske, D | 1 |
| Christoffersen, JC | 1 |
| Szendröi, Z | 1 |
| Kissel, P; Mauuary, G; Royer, R; Toussain, P | 1 |
| Gröbner, W | 3 |
| Coughlan, MP; Johnson, DB | 1 |
| Simmonds, HA | 3 |
| Murphy, TF | 1 |
| Mertz, DP; Rusteborg, J | 1 |
| Spahr, RC | 1 |
| Watts, RW | 4 |
| Barber, MJ; Bray, RC; Lowe, DJ | 1 |
| Boss, GR; Seegmiller, JE | 1 |
| Gröbner, W; Zöllner, N | 4 |
| Einhorn, LH; Stewart, A; Szwed, J; Wilson, D | 1 |
| Mir, MA | 1 |
| Becher, R; Firusian, N | 1 |
| Gancitano, A; Pallalardo, A | 1 |
| Nyhan, WL | 4 |
| Klinenberg, JR | 1 |
| Flury, W; Montandon, A; Ruch, HR | 1 |
| Coccia, PF; Kjellstrand, CM; Lynch, RE | 1 |
| Avery, GS; Brogden, RN; Heel, RC; Speight, TM | 1 |
| Kleinschmidt, A; Schräpler, P; Schulz, E | 1 |
| Emmerson, BT | 5 |
| Mangini, RJ | 2 |
| Allan, WG; Fox, W; Girling, DJ; Horsfall, PA; Nunn, AJ; Plummer, J | 1 |
| Dorhout Mees, DJ | 1 |
| Bolli, P; Simpson, FO; Waal-Manning, HJ; Wood, AJ | 1 |
| Scott, JT | 5 |
| Gall, EP | 1 |
| Bandinelli, R; Curiel, P; Morini, PL | 1 |
| Simkin, PA | 1 |
| Gibson, T; Horner, I; Kilbourn, K; Simmonds, HA | 1 |
| Gallucci, M; Miano, L; Petta, S | 1 |
| Fox, IH; Kelley, WN | 4 |
| Elin, R; Hande, KR; Perini, F; Putterman, G | 1 |
| Arntz, HR; Dreykluft, HR; Leonhardt, H | 1 |
| Beller, FK; Möhlen, KH | 1 |
| Adachi, H; Motomatsu, K; Yara, I | 1 |
| Johnson, WJ; O'Duffy, JD | 1 |
| Alsabti, E | 2 |
| Huber, R; Matouschek, E | 1 |
| König, HJ | 1 |
| Bálint, I; Bodrogi, I | 1 |
| Zacharias, F | 1 |
| Sergent, JS | 1 |
| Heidelmann, G | 2 |
| Godin, M | 1 |
| Altus, RE; Kirschner, I; Schwenke, R | 1 |
| Barsom, S | 1 |
| Bencić, K; Grims, P; Tomasović, D | 1 |
| Draxler, G; Putz, FJ; Scholz, D; Schwille, PO | 1 |
| Butler, RC; Grunow, WA; Shah, SM; Texter, C | 1 |
| Heidelmann, G; Schröder, HE; Thiele, P | 1 |
| Sumi, T; Umeda, Y | 1 |
| Hallmark, MR; Hixson, CV; Perini, F; Putterman, GJ; Sawyer, CG; Shaikh, B | 1 |
| van Dijk, JP; van Kreel, BK | 1 |
| Mangat, IS; Pamnani, S | 1 |
| Currie, WJ; Turmer, P; Young, JH | 1 |
| Devulder, B; Flouvier, B | 1 |
| Eckman, LN; Lynch, EC | 1 |
| Johnson, GF; Kiser, EJ; Witte, DL | 1 |
| Boĭtsova, NA; Lebedev, VP; Tsybysheva, AK | 1 |
| Yü, TF | 3 |
| Evans, EF; Lindsey, SW | 1 |
| Cohen, LB; Medline, A; Sellers, EM; Tobe, BA | 1 |
| Cieślak, A; Milewski, JB; Nartel-Ulkowska, N; Wesołowski, S | 1 |
| Greenberg, BP; Wexler, BC | 1 |
| Cunningham, SK; Keaveny, TV | 2 |
| Brami, M; Chanard, J; Funck-Brentano, JL; Kamoun, P | 1 |
| Iakovlev, NN; Krasnova, AF; Samodanova, GI; Usik, SV | 1 |
| Coe, FL | 6 |
| Goebel, FD; Gröbner, W; Ohlschlägel, G; Zöllner, N | 1 |
| Eason, AA; Sharlip, ID; Spaulding, JT | 1 |
| Cartier, P; Perignon, JL | 1 |
| Taylor, AK; Taylor, SI | 1 |
| Flügel, M; Geldmacher, J | 1 |
| Akaoka, I; Masuda, T; Nishida, Y; Nishizawa, T | 1 |
| Barilla, DE; Brinkley, L; Holt, K; Pak, CY; Tolentino, R; Zerwekh, JE | 1 |
| Chartrand, A; Johnson, WJ | 1 |
| Mathieson, A; Paterson, PJ; Scott, R; Smith, M | 1 |
| Loewer, H; Mertz, DP | 1 |
| Barthelemy, M; Bouchard, P; Dauchy, F; Teillaud, C; Zittoun, R | 1 |
| Berthoux, FC | 1 |
| Hartung, R | 1 |
| Fanelli, GM; Weiner, IM | 2 |
| Baer, JE; Baldwin, JJ; Duggan, DE; Noll, RM; Novello, FC | 1 |
| Bogusky, RT; Lowenstein, JM; Lowenstein, LM | 1 |
| Christiansen, LV; Hendel, J | 1 |
| Kizaki, H; Matsuo, I; Sakurada, T | 1 |
| Spector, T | 1 |
| Fox, IH | 3 |
| Förster, H; Hoos, I | 1 |
| Gröbner, W; Rauch-Janssen, A; Walter, I; Zöllner, N | 1 |
| Fox, IH; Sinclair, DS | 1 |
| de Vries, A; Kelley, WN; Rapado, A; Scott, JT; Seegmiller, JE; Watts, RW; Wyngaarden, JB; Zöllner, N | 1 |
| Cadenhead, A; Cameron, JS; Farebrother, D; Simmonds, HA | 1 |
| Cameron, JS; McBurney, A; Simmonds, HA; Van Acker, KJ | 1 |
| Appelboom, T; Famaey, JP | 1 |
| Cameron, JS; Potter, C; Simmonds, HA; Van Acker, KJ | 1 |
| Ogawa, Y; Yonetani, Y | 1 |
| Ishii, M; Ogawa, Y; Yamada, K; Yonetani, Y | 1 |
| Dwosh, IL; Fox, IH; Marliss, E; Roncari, DA | 1 |
| Brzozowska, AM; Eyman, E; Kawenoki-Minc, E; Weryńska-Przybylska, J | 1 |
| Brami, M; Brunois, JP; Chanard, J; Funck-Brentano, JL; Kamoun, P; Pleau, JM | 1 |
| Adachi, H | 1 |
| Fox, IH; Hsu, AC; Izukawa, T; Kooh, SW | 1 |
| Eyman, E; Kawenoki-Minc, E | 1 |
| Lowenthal, DT | 1 |
| Alalu, J; Espiritu, CR; Glueckauf, LG; Lubin, J | 1 |
| Brodan, V; Kuhn, E; Pechar, J | 1 |
| Hoagland, HC; Perry, MC; Wagoner, RD | 1 |
| Berg, G; Matzkies, F | 3 |
| Bobbioni, E; Butturini, U; Coscelli, C; Lugari, R; Zavaroni, I | 1 |
| Galli, L; Privitera, O | 1 |
| Kelley, WN | 4 |
| Schräpler, P; Schulz, E | 1 |
| Steele, TH; Underwood, JL | 1 |
| Bayón, JM; Crespo, M; Málaga, S; Matesanz, JL | 1 |
| Houston, IB; Morley, CJ; Morris-Jones, P | 1 |
| Fominykh, VG; Mansurov, AN; Poddubnaia, IV | 1 |
| Prien, EL | 1 |
| Brewis, I; Ellis, RM; Scott, JT | 1 |
| Raderecht, C; Schäfer, C | 1 |
| Kaszewska-Jablońska, I; Zielińska, W | 1 |
| Cumming, JD; Quebbemann, AJ; Shideman, JR; Toledo-Pereyra, L | 1 |
| Nachev, P; White, AG | 1 |
| Bayani-Sioson, PS; Torralba, TP | 1 |
| Brewis, ID; Loebl, WY; Scott, JT | 1 |
| Crawhall, JC; Khan, AH; Wilson, S | 1 |
| Castrillo, JM; Castro Mendoza, HJ; Cifuentes Delatte, L; Frutos, M; Rapado, A | 1 |
| Carnelli, V; Corbella, E; Masera, G; Uderzo, C | 1 |
| Nicholson, G | 1 |
| Elion, GB; Robin, JA; Rodnan, GP; Tolchin, SF | 1 |
| Galen, MA; Hampers, CL; Jaffe, N; Lazarus, JM; Lowrie, EG; Steinberg, SM | 1 |
| Heffron, JJ; Isaacs, H | 1 |
| Förster, W; Sziegoleit, W; Taube, C; Terhaag, B | 2 |
| Abraham, J; Damewood, CA; Hopkins, RW; Simeone, FA | 1 |
| Hahn, S; Klotz, HG; Koller, G | 1 |
| Künzer, W | 1 |
| Griebsch, A; Zöllner, N | 2 |
| Marcolongo, R; Micheli, V; Pompucci, G | 1 |
| Kawamura, T | 1 |
| Horváth, I; Kodák, Z | 1 |
| Naess, K | 1 |
| Siegenthaler-Zuber, G | 1 |
| Chatys-Górska, L; Szymborski, J | 1 |
| Bandhauer, K | 1 |
| Balis, ME; Yip, LC | 1 |
| Fumero, B; Gonzalez-Mora, JL; Guadalupe, T; Mas, M | 1 |
| Evans, RA; Parks, DA; Prodanov, E; Radi, R; Tan, S | 1 |
| Iimura, O; Nakata, T | 1 |
| Bosch, KS; Frederiks, WM; Kooij, A; Van Noorden, CJ | 1 |
| Kanemitsu, H; Nakayama, H; Nihei, H; Oka, H; Sano, K; Tamura, A | 1 |
| Cardelli, P; Ceci, F; Fiori, A; Peresempio, V; Salerno, C; Santulli, MC; Savi, MR; Strom, R | 1 |
| Matzkies, F | 3 |
| Hiroshige, K; Kunifuji, Y; Kuroiwa, A; Takasugi, M | 1 |
| Galun, AN; Galun, NM | 1 |
| Gast, LF | 1 |
| Cannell, PK; Herrmann, RP | 1 |
| Ito, H; Kanno, T; Maekawa, M; Matsumoto, K; Usami, M; Yokoi, N | 1 |
| Erhardt, W; Giesecke, D; Heiss, G; Rosskopf, R | 1 |
| Campos, R; Garrido, A; Sanhueza, J; Valdes, J; Valenzuela, A | 1 |
| Kawada, J | 1 |
| Hayashi, T; Hosoya, T; Sakai, O; Tabe, A | 1 |
| Addadi, L; Caspi, D; Kam, M; Perl-Treves, D | 1 |
| Prodanov, E; Radi, R; Rubbo, H | 1 |
| Konstantinova, SG; Russanov, EM; Russanova, IE | 1 |
| Beal, MF; Matson, WR; Miller, JM; Uemura, Y | 1 |
| Barthelemy, CR; McCarthy, GM; Veum, JA; Wortmann, RL | 1 |
| Guerciolini, R; Szumlanski, C; Weinshilboum, RM | 1 |
| Abdurakhmanova, SK; Akhmatov, A; Ishkabulov, DI; Tukhvatulina, RR | 1 |
| Nishino, T; Sato, S; Tatsumi, K | 1 |
| Akaoka, I; Fujimori, S; Kaneko, K | 1 |
| Di Cosmo, C; Di Mele, AL; Giacomello, A; Morelli, E; Quaratino, CP; Romano, C; Sforza, GR | 1 |
| Friedl, HP; Till, GO; Trentz, O; Ward, PA | 2 |
| Massie, HR; Shumway, ME; Whitney, SJ | 1 |
| Klompmaker, IJ; Pruim, J; Slooff, MJ; ten Vergert, EM; Verwer, R | 1 |
| Huang, X; Liang, S; Shi, Y; Tian, Z; Wu, X; Xiao, X; Yin, Q; Yuan, H | 1 |
| Hosoya, T; Ichida, K; Sakai, O; Tabe, A | 1 |
| Kim, L; Kulikov, V; Menshikova, E; Mikichur, N; Safronov, I; Zenkov, N | 1 |
| Becker, BF; Gerlach, E; Leipert, B; Permanetter, B; Raschke, P; Reinholz, N | 1 |
| Shinosaki, T; Yonetani, Y | 1 |
| Friedl, HP; Till, GO; Ward, PA | 1 |
| Hasegawa, J; Hisatome, I; Ishiko, R; Kotake, H; Mashiba, H; Miyamoto, J; Ogino, K; Saitoh, M | 1 |
| Arenas Adarve, M; Arenas Jiménez, MD; Boronat Botella, M; Mengual Alarte, MJ; Roca Villanueva, B; Sastre Pascual, JF; Zamora Navarro, S | 1 |
| Birkett, DJ; Day, RO; Miners, JO | 1 |
| Futterweit, S; Trachtman, H; Valderrama, E | 1 |
| Betz, AL; Martz, D; Randall, J | 1 |
| Grover, PK; Marshall, VR; Ryall, RL | 1 |
| Bos, E; De Jong, JW; Huizer, T; Roelandt, JR; Serruys, PW; van der Meer, P | 1 |
| Fam, AG | 2 |
| Hultkvist-Bengtsson, U; Mårtensson, L | 1 |
| Bhuvapanich, S; Bunnag, S; Chalaprawat, M; Jitapunkul, S; Kangkaya, V; Pasatrat, S; Vajanamarhutue, C | 1 |
| Joseph, MH; Young, AM | 1 |
| Coady, K; Herzberg, GR; MacCharles, G; Maddigan, B | 1 |
| Yamanaka, H | 2 |
| Bougle, D; Bureau, F; Duhamel, JF; Foucault, D; Voirin, J | 1 |
| Williams-Larson, AW | 1 |
| Berg, H | 1 |
| Godin, DV; Ko, KM | 1 |
| Kawada, J; Nishida, M; Nukatsuka, M; Yoshimura, Y | 1 |
| Halliwell, B; Kaur, H | 1 |
| Acerbo, S; Allegrini, S; Bertelli, R; Cercignani, G; D'Allegri, F; Ghiggeri, G; Ginevri, F; Gusmano, R; Oleggini, R; Perfumo, F | 1 |
| Prodanov, E; Radi, R; Rubbo, H; Thomson, L | 1 |
| Bilenko, MV; Nagler, LG; Oktiabr'skaia, LA; Rashba, IuE; Vartanian, LS | 1 |
| Gömör, B; Szebenyi, B | 1 |
| Conger, JD | 1 |
| Schoeneman, MJ | 1 |
| Fiskin, AM; Garrison, RG; Zalles, MC | 1 |
| Iguchi, M; Ishikawa, Y; Kataoka, K; Katayama, Y; Katoh, Y; Kodama, M; Kohri, K; Kurita, T; Takada, M | 1 |
| Akiyama, T; Ikegami, M; Imanishi, M; Ishii, T; Kanda, H; Kunikata, S; Kurita, T; Matsuura, T; Nishioka, T; Uemura, T | 1 |
| Foreman, JW; Yudkoff, M | 1 |
| Eklof, B; Jabs, CM; Neglen, P; Thomas, EJ | 1 |
| Garcia Garcia, J; Gomez Alonso, A; Holgado Madruga, M; Macias Nuñez, JF; Mariño Hernandez, E; Martin Rollan, C; Refoyo Enrinquez, MA | 1 |
| Okafuji, K; Shinohara, K | 1 |
| Chen, XB; Hovell, FD; Orskov, ER | 1 |
| Batuman, V; Maesaka, JK; Salem, M; Sved, AF; Venkatesan, J; Yudd, M | 1 |
| Duncan, P; Hall, IH; Reynolds, DJ; Scoville, JP; Simlot, R | 1 |
| Kawachi, M; Kono, N; Mineo, I; Tarui, S; Yamada, Y | 1 |
| Barry, M; Feely, J | 1 |
| Iguchi, M; Ishikawa, Y; Kataoka, K; Katayama, Y; Katoh, Y; Kodama, M; Kohri, K; Kurita, T; Takada, M; Umekawa, T | 1 |
| Chaudhary, K; Kumar, A; Malaviya, AN; Singh, YN; Tripathy, S | 1 |
| Bos, E; de Jong, JW; Huizer, T; Nieukoop, AS; Stroeve, RJ; van der Meer, P | 1 |
| Knott, PJ; Mueller, KJ; Young, JG | 1 |
| Besson, JM; Noret, E; Ory-Lavollée, L; Rivot, JP | 1 |
| Gröbner, W; Löffler, W | 1 |
| Amirian, DA; Chen, MC; Olson, CE; Soll, AH | 1 |
| Beckman, JS; Duffey, ME; Freeman, BA; Matalon, S | 1 |
| Hada, T; Higashino, K; Suda, M; Takahashi, S; Yamamoto, T | 1 |
| Aruoma, OI; Halliwell, B | 1 |
| Kuppusamy, P; Zweier, JL | 1 |
| Anderson, TE; Pederson, TC; Ridella, SA | 1 |
| Oberley, LW; Spitz, DR | 1 |
| Lemasters, JJ; Thurman, RG; Zhong, Z | 1 |
| Elsayed, NM; Tierney, DF | 1 |
| Becker, BF; Gerlach, E; Leipert, B; Ozçelik, T; Reinholz, N | 1 |
| Hall, WW; Krenitsky, TA; Lambe, CU; Nelson, DJ; Porter, DJ; Spector, T | 1 |
| Hoshihara, Y; Miyamoto, T; Nishida, Y | 1 |
| Gray, JA; Hodges, H; Joseph, MH | 1 |
| Ekblom, B; Sjödin, B; Westing, YH | 1 |
| Barnard, HC; Barnard, SP; Maartens, JJ; Potgieter, GM; van Jaarsveld, H | 1 |
| Castroviejo, IP; Jiménez, ML; Mateos, FA; Puig, JG; Ramos, TH; Vázquez, JO | 1 |
| Capitán, MC; Casas, E; González, AA; Jiménez, ML; Mateos, FA; Puig, JG | 1 |
| Bull, PW; Scott, JT | 2 |
| Casas, E; Jiménez, ML; Mateos, FA; Michán, AD; Puig, JG; Ramos, TH | 1 |
| Di Stefano, A; Leoncini, R; Marinello, E; Pizzichini, M; Porcelli, B; Taddeo, A | 1 |
| Ettinger, B | 1 |
| Ritz, E; Stiefel, M; Verberckmoes, R | 1 |
| Parker, BR; Stevens, SK | 1 |
| Weber, G | 1 |
| Kocvara, R; Tuíková, J | 1 |
| Isaacs, M; Muindi, J; Stevens, YW; Warrell, RP; Young, CW | 1 |
| Boda, D; Németh, I | 1 |
| Davì, S; La Brocca, A; Leone, L; Pessano, B | 1 |
| Andreetta, F; Cighetti, G; Del Puppo, M; Kienle, MG | 1 |
| Hoffbrand, AV; O'Connor, NT; Prentice, HG | 1 |
| Vollmer, H | 1 |
| Bakhtiiarov, ZA | 1 |
| Kanemitsu, H; Nihei, H; Oka, H; Sano, K; Tamura, A | 1 |
| Oka, H | 1 |
| Iriyama, K; Iwamoto, T; Kanemitsu, H; Kirino, T; Oka, H; Sano, K; Tamura, A; Yoshiura, M | 1 |
| Andres, A; Bello, I; Diaz-Rolón, JA; Gutierrez-Millet, V; Morales, JM; Praga, M; Rodicio, JL | 1 |
| Bellamy, N; Brooks, PM; Campbell, J; Emmerson, BT; Gilbert, JR; McCredie, M | 1 |
| Bontoux, D | 1 |
| Coutellier, P; Delgrange, B | 1 |
| Castelli, A; Martorana, GE; Meucci, E; Miggiano, GA; Mordente, A; Santini, SA | 1 |
| Sorenson, JR; Willingham, WM | 1 |
| McCord, JM; Turrens, JF | 1 |
| Link, EM; Riley, PA | 1 |
| Kettle, AJ; Winterbourn, CC | 1 |
| Gerber, G; Henke, W; Müller, M; Schmidt, H; Siems, W | 1 |
| Grootveld, M; Halliwell, B; Moorhouse, CP | 1 |
| Czarnecki, CM; McVey, AS; Olivero, DK | 1 |
| Karelin, AA; Korotkina, RN; Papin, AA; Voronina, TA | 1 |
| Hehlmann, R; Jahn, M; Löffler, W; Reiter, S; Seibke, E; Seibke, W; Zöllner, N | 1 |
| Bachmann, C; Müller, U; Pewsner, D | 1 |
| Shasby, DM | 1 |
| de Groot, H; Noll, T | 1 |
| Azoury, R; Garti, N; Perlberg, S; Sarig, S | 1 |
| Cai, SL; Wei, KX; Yang, SS | 1 |
| Beindorff, CM; Biemond, P; Koster, JF; Swaak, AJ | 1 |
| German, DC; Holmes, EW | 2 |
| McCarty, DJ | 1 |
| Renwick, IG | 1 |
| Aukett, A; Bennett, MJ; Hosking, GP | 1 |
| Fam, AG; McDonald, J; Paton, T; Senn, J | 1 |
| Cabo, J; Gomez-Ruiz, MD; Izquierdo, R; Rodilla, F; Sanchez-Beltran, MJ | 1 |
| Iriyama, K; Iwamoto, T; Kanemitsu, H; Karasawa, S; Kirino, T; Sano, K; Tamura, A; Yoshiura, M | 1 |
| Cats, A; Gast, LF | 1 |
| Birkett, DJ; Day, RO; Hayes, J; Miners, JO; Naidoo, D; Savdie, E; Whitehead, A | 1 |
| Escribano, J; Garcia-Canovas, F; Garcia-Carmona, F | 1 |
| Hofbauer, J; Zechner, O | 1 |
| Chaou, M; Duwoos, H; Guyonnaud, C; Lacroix, C; Lafont, O | 1 |
| Duda, W; Szedel, A; Szurkowski, A | 1 |
| Jungermann, K; Nath, A; Püschel, GP | 1 |
| Jósfay, J; Judák, A; Ludányi, E; Mituszova, M; Poór, G | 1 |
| Davis, RH; Fraser, RC; Walker, FS | 1 |
| Bolling, SF; Deeb, GM; Gallagher, KP; Grum, CM; Lynch, MJ; Morganroth, ML | 1 |
| Bateman, DN; Ferner, RE; Simmonds, HA | 1 |
| Shimada, H; Sugino, H | 1 |
| Andreoli, SP; Bergstein, JM; Clark, JH; McGuire, WA | 1 |
| Potter, JL; Silvidi, AA | 1 |
| Boston, GD; Paton, DM; Webster, DR | 1 |
| Caelli, DJ; Faragher, RI | 1 |
| Griffith, DP; Johnston, SD; Klausner, JS; Osborne, CA; Poffenbarger, EM | 1 |
| Citron, JT; Ettinger, B; Livermore, B; Tang, A; Williams, T | 1 |
| Hesse, A; Schneeberger, W; Vahlensieck, W | 1 |
| Preminger, GM | 1 |
| Berlinger, WG; Kitt, TM; Park, GD; Spector, R; Tsalikian, E | 1 |
| Kawenoki-Minc, E | 2 |
| Emmerson, BT; Hazelton, RA; Whyte, IM | 1 |
| Dykman, D; Simon, EE | 1 |
| Hille, R; Sprecher, H | 1 |
| Kim, P; Romero, SD; Sundt, TM; Yaksh, TL | 1 |
| Krivoy, N; Weissman, I | 1 |
| Briceño, A; Monforte, MF; Peña, JC | 1 |
| Kamatani, N; Kitamura, M; Kojima, T; Nishina, T; Nishioka, K | 2 |
| Hill, CE; Olson, MS | 1 |
| Cross, M; Emmerson, BT; Gordon, RB; Thomson, DB | 1 |
| Iguchi, M; Kataoka, K; Katoh, Y; Kohri, K; Kurita, T; Takada, M; Yachiku, S | 1 |
| Benazzi, E; Colussi, G; De Ferrari, ME; Malberti, F; Minetti, L; Rombolà, G; Surian, M | 1 |
| Darlington, LG; Scott, JT | 1 |
| D'Amato, MS; Fioravanti, A; Marcolongo, R; Morozzi, G; Renieri, A; Taddeo, A | 1 |
| de Verdier, CH; Niklasson, F; van Waeg, G | 1 |
| Gröbner, W; Löffler, W; Reiter, S; Zöllner, N | 1 |
| Edwards, NL; Mateos, FA; Puig, JG | 1 |
| Campbell, ME; Grant, DM; Kalow, W; Tang, BK | 1 |
| Glazener, FS; Pan, HY | 1 |
| Cameron, JS; Davies, PM; Morris, GS; Simmonds, HA | 1 |
| Clavel, JP; Colin, JN; Dietlin, F; Farinotti, R; Fredj, G; Tod, M; Vignon, E | 1 |
| Bronk, JR; Shaw, MI | 1 |
| Kanamaru, H; Sasaki, M; Takenawa, J | 1 |
| Bimar, J; Collet, S; Desjacques, P; Divry, P; Lagier, P; Lando, A; Tessonnier, JM; Vianet-Liaud, C | 1 |
| Berger, JP; Hervé, F; Soulier, J | 1 |
| Bomalaski, JS; Lluberas, G; Schumacher, HR | 1 |
| Culham, CA; Hartshorn, JN; Haugh, LD; Krakoff, IR; McCormack, JJ; Newman, RA; Roberts, JD; Stewart, JA; Young, JA | 1 |
| Fox, IH; Jiménez, ML; Mateos, FA; Puig, JG | 1 |
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| Kawada, T | 1 |
| Dalbeth, N; Goodyear-Smith, F; Grey, C; Heather, M; Jansen, RM; Lutui, H; Ofanoa, M; Ofanoa, S; Tu'akoi, S | 1 |
| Chen, L; Dong, L; Dong, Y; Huang, J; Li, L; Long, T; Lu, J; Mao, Y; Qi, Z; Wen, J; Zhang, J; Zhang, S; Zhao, F | 1 |
| Hwang, BF; Kuo, YH; Lai, SW; Liao, KF; Liu, CS | 1 |
| Cai, Z; Dai, R; Fu, Y; Gong, Z; Kong, W; Li, W; Li, Z; Luo, C; Shen, Y; Wang, J; Wu, H; Yang, L; Yu, F; Zhang, T; Zhang, X; Zhao, H; Zhao, Y; Zhu, J | 1 |
| Mironova, OI | 1 |
| Gao, YY; Guan, HY; Guo, XL; He, X; Liao, SG; Wang, Y; Wei, MC; Xu, GB; Yang, YX; Zhang, CL; Zhang, J; Zhang, JJ; Zhu, QF; Zou, SH | 1 |
| Aquilani, S; Castello, L; Colivicchi, F; Di Fusco, SA; Flori, M; Gabrielli, D; Gulizia, MM; Marino, G; Nardi, F; Oliva, F; Riccio, C | 1 |
| Cui, Z; Huang, Y; Luo, Y; Wang, X; Yang, X | 1 |
| Do, JY; Kang, SH; Kim, BY; Kim, GO; Son, EJ | 1 |
| Hua, L; Shi, S; Yang, J; Zhang, S; Zhou, X | 1 |
| Bao, Z; Dong, L; Dong, Y; Lin, S; Wang, X | 1 |
| Gao, J; Li, D; Wang, C; Wu, Y; Wu, Z; Zhang, X; Zhou, J | 1 |
| Hao, G; He, Z; Lin, X; Wang, M | 1 |
| Adeyemi, DH; Akhigbe, RE; Akhigbe, TM; Ashonibare, PJ; Besong, EE; Folawiyo, MA; Hamed, MA; Obembe, OO | 1 |
| Fujii, M; Fukuoka, T; Hirohata, S; Honma, K; Kakimoto, M; Kirihara, S; Kitamori, K; Nakayama, H; Ran, S; Sato, I; Watanabe, S; Yamamoto, S | 1 |
| Kim, AR; Lee, SG; So, MW | 1 |
| An, J; Li, C; Li, Y; Lin, F; Ma, S; Wang, S; Xie, Y; Xu, L; Zhang, Y; Zhao, Y | 1 |
| Huang, XY; Li, W; Liu, HB; Liu, T; Luo, T; Luo, Y; Wu, Y; Yang, M; Zhang, YL | 1 |
| Hou, C; Ke, X; Wang, Y; Wu, T; Yang, R; Yang, X; Zhou, Y | 1 |
| Chapman, PT; Dalbeth, N; Drake, J; Frampton, C; Haslett, J; Horne, A; Mihov, B; Stamp, L | 1 |
| Lioté, F; Pérez-Ruiz, F; Schlesinger, N | 1 |
| Ahluwalia, A; Birchall, K; Borghi, C; Chapman, T; Dyson, N; Khambata, RS; Massimo, G; Raimondi, C; Rathod, KS; Shabbir, A | 1 |
| Bajpai, R; Clarson, LE; Forrester, H; Mallen, CD; Muller, S; Padmanabhan, N; Partington, RJ; Roddy, E; Whittle, R | 1 |
| Fan, Y; Liu, Y; Meng, Y; Qin, M; Wu, D; Zeng, X | 1 |
| Bian, W; Fu, Z; Li, C; Liu, N; Liu, Y; Peng, Y; Ru, Z; Wang, Y; Wu, Y; Yang, X; Zhang, Y | 1 |
288 review(s) available for uric acid and allopurinol
| Article | Year |
|---|---|
Implications of disorders of purine metabolism for the kidney and the urinary tract.
Topics: Adenine Phosphoribosyltransferase; Allopurinol; Animals; Calcium; Gout; Humans; Hydrogen-Ion Concentration; Hypoxanthine Phosphoribosyltransferase; Kidney Calculi; Kidney Diseases; Kidney Failure, Chronic; Oxypurinol; Purines; Sodium; Solubility; Uric Acid; Urologic Diseases; Xanthine Oxidase; Xanthines | 1977 |
Metabolic causes of renal stone formation.
Topics: Adenine Phosphoribosyltransferase; Cystinuria; Glycogen Storage Disease Type I; Humans; Hypoxanthine Phosphoribosyltransferase; Kidney Calculi; Metabolism, Inborn Errors; Orotic Acid; Oxalates; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Xanthine Oxidase; Xanthines | 1977 |
Hyperuricemia and gout. Classification, complications and management.
Topics: Acute Disease; Allopurinol; Arthritis; Aspirin; Colchicine; Coronary Disease; Diuretics; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Indomethacin; Kidney; Kidney Calculi; Kidney Diseases; Lead Poisoning; Lymphoproliferative Disorders; Myeloproliferative Disorders; Phenylbutazone; Platelet Aggregation; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrazinamide; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Uricosuric Agents | 1979 |
Hyperuricemia and gout.
Topics: Adult; Allopurinol; Colchicine; Diagnosis, Differential; Female; Gout; Humans; Indomethacin; Male; Middle Aged; Phenylbutazone; Prognosis; Uric Acid; Uricosuric Agents | 1977 |
Renal and metabolic complications of childhood non-Hodgkin's lymphoma.
Topics: Acidosis; Acute Kidney Injury; Allopurinol; Aluminum Hydroxide; Burkitt Lymphoma; Child; Humans; Hypercalcemia; Hyperlipidemias; Hypertension, Renal; Hypoglycemia; Lymphoma; Male; Mannitol; Metabolic Diseases; Phosphorus Metabolism Disorders; Uric Acid; Xanthines | 1977 |
Benzbromarone: a review of its pharmacological properties and therapeutic use in gout and hyperuricaemia.
Topics: Aspirin; Benzbromarone; Benzofurans; Drug Interactions; Fasting; Gout; Humans; Kidney Diseases; Kinetics; Lipid Metabolism; Pyrazinamide; Triglycerides; Uric Acid; Xanthine Oxidase | 1977 |
[Gout. Diagnosis--pathogenesis--therapy].
Topics: Allopurinol; Balneology; Benzofurans; Crystallization; Diagnosis, Differential; Exercise Therapy; Glomerular Filtration Rate; Gout; Probenecid; Sulfinpyrazone; Uric Acid; Urinary Calculi | 1978 |
Drug control of gout and hyperuricaemia.
Topics: Allopurinol; Arthritis; Chronic Disease; Colchicine; Gout; Humans; Indomethacin; Naproxen; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1978 |
Pathogenesis and clinical management of hyperuricemia and gout.
Topics: Allopurinol; Colchicine; Female; Gout; Humans; Kidney Calculi; Male; Uric Acid; Uricosuric Agents | 1979 |
[Uric acid metabolism, specifically the effect of diuretics on the process].
Topics: Allopurinol; Biological Transport; Diuretics; Glomerular Filtration Rate; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Kidney Diseases; Kidney Tubules; Lactates; Lesch-Nyhan Syndrome; Nucleosides; Nucleotides; Purines; Risk; Sodium; Uric Acid | 1979 |
2,8-Dihydroxyadeninuria--or when is a uric acid stone not a uric acid stone?
Topics: Acute Kidney Injury; Adenine; Adenine Phosphoribosyltransferase; Allopurinol; Diagnosis, Differential; Diet; Heterozygote; Homozygote; Humans; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Urinary Calculi | 1979 |
Choice of treatment in gout.
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Gout; Humans; Long-Term Care; Uric Acid | 1977 |
Pharmacologic approach to the maintenance of urate homeostasis.
Topics: Allopurinol; Diuresis; Gout; Homeostasis; Humans; Kidney Tubules; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1975 |
Calcium oxalate renal stones.
Topics: Allopurinol; Calcium; Calcium Metabolism Disorders; Calcium Phosphates; Calcium, Dietary; Crystallization; Humans; Kidney Calculi; Magnesium Oxide; Oxalates; Phosphates; Pyridoxine; Recurrence; Thiazines; Uric Acid | 1975 |
[New hypotheses for the mechanisms of streptozotocin and alloxan inducing diabetes mellitus].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alloxan; Animals; Diabetes Mellitus, Experimental; DNA Damage; Free Radicals; Hypoxanthine; Hypoxanthines; Islets of Langerhans; Mitochondria; Reactive Oxygen Species; Streptozocin; Uric Acid; Xanthine Oxidase | 1992 |
Role of uric acid as an endogenous radical scavenger and antioxidant.
Topics: Animals; Coronary Vessels; Endothelium, Vascular; Free Radical Scavengers; Humans; Luminescent Measurements; Lung; Myocardium; Oxygen; Uric Acid; Xanthine Oxidase | 1991 |
Strategies and controversies in the treatment of gout and hyperuricaemia.
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Diet; Gout; Humans; Uric Acid; Uricosuric Agents | 1990 |
[Medical control of uric acid in patients with gout--desirable level of serum uric acid and the choice of drugs].
Topics: Allopurinol; Gout; Humans; Uric Acid | 1991 |
Urinary calculi associated with purine metabolism. Uric acid nephrolithiasis.
Topics: Adenine Phosphoribosyltransferase; Humans; Kidney Calculi; Lesch-Nyhan Syndrome; Purines; Risk Factors; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1990 |
Milurit's place in therapy.
Topics: Allopurinol; Drug Interactions; Humans; Uric Acid | 1990 |
Acute uric acid nephropathy.
Topics: Acute Disease; Allopurinol; Chemical Phenomena; Chemistry, Physical; Humans; Kidney; Kidney Diseases; Renal Dialysis; Uric Acid | 1990 |
Does hyperuricosuria play a role in calcium oxalate lithiasis?
Topics: Allopurinol; Calcium Oxalate; Humans; Uric Acid; Urinary Calculi | 1989 |
[Is asymptomatic hyperuricemia in kidney-failure patients in need of therapy?].
Topics: Allopurinol; Gout; Humans; Kidney; Kidney Failure, Chronic; Uric Acid | 1989 |
Hyperuricemia and gout.
Topics: Acute Disease; Adult; Allopurinol; Anti-Inflammatory Agents; Arthritis; Arthrography; Calcinosis; Chronic Disease; Colchicine; Female; Gout; Humans; Kidney Calculi; Kidney Diseases; Middle Aged; Probenecid; Uric Acid | 1986 |
Etiopathogenesis, clinical manifestations, and management of canine calcium oxalate urolithiasis.
Topics: Allopurinol; Animals; Benzothiadiazines; Calcium Oxalate; Cellulose; Citrates; Crystallization; Diuretics; Dog Diseases; Dogs; Hypercalcemia; Magnesium; Methylene Blue; Phosphates; Sodium Chloride Symporter Inhibitors; Uric Acid; Urinary Calculi | 1986 |
[Conservative therapy of chronic renal failure].
Topics: Allopurinol; Aluminum; Anemia; Antihypertensive Agents; Blood Transfusion; Bone Diseases; Diet Therapy; Diet, Sodium-Restricted; Diuretics; Humans; Hydroxides; Hypertension; Kidney Failure, Chronic; Palliative Care; Parathyroid Glands; Uric Acid; Vitamin D | 1969 |
[Non-specific basic therapy of leukemias and their complications].
Topics: Acute Disease; Adrenal Cortex Hormones; Allopurinol; Anemia; Autoimmune Diseases; Blood Coagulation Disorders; Blood Platelets; Blood Transfusion; Chronic Disease; Granulocytes; Humans; Infection Control; Leukemia; Uric Acid | 1974 |
Phosphoribosylpyrophosphate in man: biochemical and clinical significance.
Topics: Adenine; Adrenocorticotropic Hormone; Allopurinol; Animals; Glycogen; Gout; Humans; Lesch-Nyhan Syndrome; Methylene Blue; Orotic Acid; Pentosephosphates; Phosphoric Acids; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribose; Thiadiazoles; Thyrotropin; Transferases; Urate Oxidase; Uric Acid | 1971 |
The existence of nonfunctional active sites in milk xanthine oxidase: reaction with functional active site inhibitors.
Topics: Allopurinol; Animals; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Electron Spin Resonance Spectroscopy; Enzyme Activation; Ferricyanides; Kinetics; Milk; Oxidation-Reduction; Pyrazoles; Pyrimidines; Spectrophotometry; Uric Acid; Xanthine Oxidase; Xanthines | 1970 |
Symposium on renal lithiasis. Medical evaluation of urolithiasis. Etiologic aspects and diagnostic evaluation.
Topics: Acidosis, Renal Tubular; Bacterial Infections; Citrates; Crystallization; Cystinuria; Diphosphates; Female; Gastrointestinal Diseases; Humans; Hypercalcemia; Hyperparathyroidism; Magnesium; Male; Metabolism, Inborn Errors; Mucoproteins; Oxalates; Quaternary Ammonium Compounds; Sarcoidosis; Solubility; Uric Acid; Urinary Calculi; Vitamin D; Xanthine Oxidase | 1974 |
[Regulation of synthesis of uric acid as the final stage of nitrogen metabolism].
Topics: Animals; Chickens; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Glycine; Humans; Hypoxanthines; Inosine; Inosine Nucleotides; Liver; Nitrogen; Nucleotidases; Phosphorylase Kinase; Rats; Serine; Uremia; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
The physiologic approach to hyperuricemia.
Topics: Allopurinol; Gout; Humans; Kidney; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Uricosuric Agents | 1972 |
Diagnosis and treatment of the Lesch-Nyhan syndrome.
Topics: Allopurinol; Amniocentesis; Athetosis; Brain; Erythrocytes; Fibroblasts; Humans; Intellectual Disability; Lesch-Nyhan Syndrome; Male; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Uric Acid | 1972 |
Cancer chemotherapy. 3.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Allopurinol; Alopecia; Antimetabolites; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Drug Synergism; Female; Fetus; Humans; Kidney Calculi; Kidney Diseases; Kidney Tubules; Mechlorethamine; Mercaptopurine; Neoplasms; Pregnancy; Pregnancy Complications; Uric Acid; Vincristine | 1972 |
Hyperuricemia in leukemia and lymphoma. I. Clinical findings and pathophysiology.
Topics: Acute Kidney Injury; Allopurinol; Child; Child, Preschool; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Kidney Tubules; Leukemia; Lymphoma; Male; Nucleoproteins; Radiotherapy; Uric Acid | 1973 |
Hyperuricemia in leukemia and lymphoma. II. Treatment.
Topics: Acetazolamide; Allopurinol; Humans; Kidney Diseases; Leukemia; Lymphoma; Renal Dialysis; Uric Acid | 1973 |
[Effect of allopurinol on the metabolism of uric acid].
Topics: Allopurinol; Chemical Phenomena; Chemistry; Depression, Chemical; Feedback; Gout; Humans; Kidney; Purines; Uric Acid; Xanthine Oxidase | 1973 |
[Physical, chemical and biological bases for the treatment and prevention of urolithiasis].
Topics: Acid-Base Equilibrium; Allopurinol; Diet Therapy; Humans; Postoperative Complications; Uric Acid; Urinary Calculi; Urinary Catheterization; Urinary Tract Infections | 1973 |
The Lesch-Nyhan syndrome.
Topics: Allopurinol; Animals; Brain; Chromosome Aberrations; Chromosome Disorders; Guanine; Humans; Hypoxanthines; Lesch-Nyhan Syndrome; Male; Metabolism, Inborn Errors; Pentosyltransferases; Purines; Rabbits; Rats; Uric Acid | 1973 |
Orotic acid.
Topics: Allopurinol; Anemia, Pernicious; Animals; Azauridine; Carboxy-Lyases; Fatty Liver; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Lipids; Metabolic Diseases; Metabolism, Inborn Errors; Milk; Myocardial Infarction; Ornithine Carbamoyltransferase; Orotic Acid; Pentosyltransferases; Pregnancy; Uric Acid | 1973 |
Aetiology of gout.
Topics: Allopurinol; Creatinine; Diet Therapy; Erythrocytes; Gout; Humans; Hypoxanthines; Lesch-Nyhan Syndrome; Metabolism, Inborn Errors; Myeloproliferative Disorders; Pentosyltransferases; Prenatal Diagnosis; Protein Binding; Purines; Uric Acid | 1973 |
Drug induced gout.
Topics: Absorption; Allopurinol; Aspirin; Benzothiadiazines; Diuretics; Ethanol; Gout; Humans; Kidney Calculi; Kidney Tubules; Sodium Chloride Symporter Inhibitors; Uric Acid; Uricosuric Agents | 1973 |
Current management of polycythemia vera and related diseases.
Topics: Allopurinol; Bloodletting; Chlorambucil; Erythropoiesis; Gout; Humans; Melphalan; Phosphorus Radioisotopes; Polycythemia Vera; Uric Acid | 1974 |
Purine ribonucleotide catabolism: clinical and biochemical significance. Review.
Topics: Adenosine Triphosphate; Allopurinol; Animals; Carbohydrate Metabolism, Inborn Errors; Fructose; Humans; Metabolic Diseases; Metabolism, Inborn Errors; Myocardial Infarction; Oxidation-Reduction; Purine Nucleotides; Ribonucleotides; Shock, Hemorrhagic; Uric Acid | 1974 |
Influence of various purines on uric acid metabolism.
Topics: Adenosine Monophosphate; Allopurinol; Diet; Diet Therapy; DNA; Dose-Response Relationship, Drug; Eukaryota; Food Analysis; Guanine Nucleotides; Humans; Plant Proteins; Purines; RNA; Uremia; Uric Acid; Xanthine Oxidase | 1973 |
[Danger of hyperuricemia in the treatment of acute leukemia, lymphosarcoma and reticulosarcoma].
Topics: Acute Disease; Allopurinol; Antineoplastic Agents; Child; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Prednisone; Uric Acid; Xanthine Oxidase | 1974 |
Genetic aspects of gout.
Topics: Adenine; Allopurinol; Carbon Radioisotopes; Erythrocytes; Fibroblasts; Glucosephosphate Dehydrogenase; Glutamine; Glutathione Reductase; Gout; Guanine; Humans; Hypoxanthines; Lesch-Nyhan Syndrome; Liver; Metabolic Diseases; Molecular Weight; Orotic Acid; Pentosyltransferases; Purines; Uric Acid; Xanthine Oxidase | 1974 |
Milestones in the treatment of gout.
Topics: Allopurinol; Colchicine; Gout; Humans; Indomethacin; Kidney Calculi; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1974 |
Hypercalciuria and hyperuricosuria in patients with calcium nephrolithiasis.
Topics: Allopurinol; Calcium; Calcium Metabolism Disorders; Diet; Diuretics; Female; Humans; Intestinal Absorption; Kidney Calculi; Kidney Tubules; Male; Parathyroid Hormone; Phosphates; Purines; Radiography; Sodium Chloride Symporter Inhibitors; Trichlormethiazide; Uric Acid | 1974 |
[Metabolic factors associated with urolithiasis. Part II (author's transl)].
Topics: Allopurinol; Bile Acids and Salts; Calcium; Diuretics; Humans; Hydrogen-Ion Concentration; Hyperparathyroidism; Kidney; Lesch-Nyhan Syndrome; Purines; Uric Acid; Urinary Calculi | 1974 |
Molecular variation in relation to purine metabolism.
Topics: Amidophosphoribosyltransferase; Chemical Phenomena; Chemistry; Glucosephosphate Dehydrogenase Deficiency; Glutathione Reductase; Gout; Humans; Inosine Monophosphate; Lesch-Nyhan Syndrome; Phosphoribosyl Pyrophosphate; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Xanthine Oxidase; Xanthines; Xeroderma Pigmentosum | 1974 |
Uric acid nephrolithiasis.
Topics: Adolescent; Aged; Allopurinol; Female; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Male; Metabolism, Inborn Errors; Middle Aged; Neoplasms; Purines; Uric Acid | 1968 |
Recent progress in the pathogenesis and treatment of gout.
Topics: Allopurinol; Gout; Humans; Uric Acid | 1969 |
Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout.
Topics: Adenine; Adolescent; Adult; Allopurinol; Azathioprine; Child; Child, Preschool; Female; Gout; Humans; Hypoxanthines; Male; Middle Aged; Pedigree; Pharmacogenetics; Phenotype; Purines; Transferases; Uric Acid | 1969 |
Physiologic and biochemical basis for the treatment of gout and hyperuricemia.
Topics: Acute Disease; Adrenal Cortex Hormones; Arthritis; Chronic Disease; Colchicine; Glomerular Filtration Rate; Gout; Phenylbutazone; Purines; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1969 |
Biosynthesis of uric acid in the tunicate, Molgula manhattensis, with a general scheme for the function of stored purines in animals.
Topics: Adenine; Allopurinol; Animals; Carbon Isotopes; Carbonates; Chordata, Nonvertebrate; Formates; Glycine; Hypoxanthines; Purines; Serine; Tritium; Uric Acid; Xanthine Oxidase | 1970 |
Gout.
Topics: Allopurinol; Arthritis; Carbon Isotopes; Colchicine; Glutamine; Gout; Humans; Kidney; Orotic Acid; Purines; Uric Acid | 1965 |
Current status of canine urolithiasis.
Topics: Administration, Oral; Age Factors; Allopurinol; Animals; Anti-Bacterial Agents; Bicarbonates; Cystine; Diet Therapy; Dog Diseases; Dogs; Female; Hydrogen-Ion Concentration; Male; Oxalates; Phosphates; Postoperative Complications; Sex Factors; Uric Acid; Urinary Calculi; Urinary Tract Infections | 1971 |
[Uric acid calculosis].
Topics: Adolescent; Adult; Aged; Alkalies; Allopurinol; Chemistry Techniques, Analytical; Child; Child, Preschool; Citrates; Diet; Female; Humans; Hypoxanthines; Infant; Male; Middle Aged; Purines; Uric Acid; Urinary Calculi; Xanthines | 1970 |
[Drug therapy in gout].
Topics: Allopurinol; Chemical Phenomena; Chemistry; Colchicine; Gout; Humans; Phagocytosis; Probenecid; Purines; Uric Acid | 1971 |
Treatment of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Colchicine; Gout; Humans; Indomethacin; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase; Xanthines | 1971 |
[What is certain in gout therapy?].
Topics: Acute Disease; Allopurinol; Chronic Disease; Colchicine; Gout; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Kidney Tubules; Probenecid; Purines; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1971 |
[Gout].
Topics: Allopurinol; Chondrocalcinosis; Colchicine; Diagnosis, Differential; Diet Therapy; Gout; Humans; Inosine Nucleotides; Joint Diseases; Metabolic Diseases; Orotic Acid; Purines; Urate Oxidase; Uric Acid; Uricosuric Agents | 1970 |
Allopurinol. A review.
Topics: Adult; Allopurinol; Child; Drug Hypersensitivity; Drug Interactions; Gout; Humans; Iron; Kidney Diseases; Nucleic Acids; Purines; Pyrimidines; Tryptophan; Uric Acid; Urinary Calculi; Xanthines | 1971 |
Drug treatment of gout.
Topics: Acute Disease; Allopurinol; Arthritis; Colchicine; Gout; Humans; Orotic Acid; Probenecid; Structure-Activity Relationship; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1971 |
Selected aspects of the aetiology, pathogenesis and treatment of disorders of purine metabolism.
Topics: Allopurinol; Colchicine; Glycogen Storage Disease Type I; Gout; Humans; Lesch-Nyhan Syndrome; Metabolism, Inborn Errors; Pentosyltransferases; Purine Nucleotides; Purines; Uric Acid | 1971 |
Drugs and uric acid.
Topics: Allopurinol; Chemical Phenomena; Chemistry; Gout; Humans; Purines; Uric Acid; Xanthines | 1969 |
Chemotherapy and comparative biochemistry: G. H. A. Clowes memorial lecture.
Topics: Allopurinol; Animals; Antimetabolites; Azathioprine; Binding Sites; Drug Therapy; Enzyme Inhibitors; Enzyme Precursors; Folic Acid; Folic Acid Antagonists; Humans; Lactobacillus; Leukemia, Myeloid; Liver; Mercaptopurine; Methotrexate; Mice; Molecular Weight; Neoplasms; Nucleic Acids; Proteus; Purines; Research; Species Specificity; Thymine; Transferases; Uric Acid; Xanthine Oxidase | 1969 |
Effects of allopurinol in relation to purine biosynthesis.
Topics: Allopurinol; Animals; Dogs; Enzymes; Humans; Hypoxanthines; Purines; Rats; Uric Acid; Xanthine Oxidase; Xanthines | 1966 |
Disorders associated with purine and pyrimidine metabolism.
Topics: 5'-Nucleotidase; Adenine Phosphoribosyltransferase; Adenosine Deaminase; AMP Deaminase; Gout; Guanine Deaminase; Humans; Hypoxanthine Phosphoribosyltransferase; Immunologic Deficiency Syndromes; Nucleotidases; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidines; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Xanthine Oxidase | 1984 |
Urate nephropathy.
Topics: Allopurinol; Arthritis; Aspirin; Blood Urea Nitrogen; Glomerular Filtration Rate; Gout; Humans; Kidney Diseases; Uric Acid | 1984 |
Kidney stones: current issues in diagnosis and therapy.
Topics: Allopurinol; Benzothiadiazines; Calcium Oxalate; Diuretics; Humans; Hydrogen-Ion Concentration; Hypercalcemia; Nephrocalcinosis; Phosphates; Sodium Chloride Symporter Inhibitors; Uric Acid | 1982 |
[Various pathophysiological, clinical and therapeutic problems of disorders of purine metabolism].
Topics: Acute Kidney Injury; Allopurinol; Diuretics; Gout; Humans; Kidney Calculi; Uric Acid | 1982 |
Treatment of the gout and other forms of crystal-induced arthritis.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzbromarone; Colchicine; Gout; Gout Suppressants; Humans; Indomethacin; Kidney; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1982 |
Long-term management of gout and hyperuricaemia.
Topics: Allopurinol; Female; Gout; Humans; Long-Term Care; Male; Risk; Uric Acid; Uricosuric Agents | 1980 |
[Hyperuricemia, gout and gout-induced nephropathy].
Topics: Allopurinol; Female; Gout; Humans; Kidney Calculi; Male; Nephritis, Interstitial; Purines; Uric Acid | 1980 |
Treatment of renal calculi.
Topics: Acidosis, Renal Tubular; Allopurinol; Benzothiadiazines; Calcium; Calcium, Dietary; Cystinuria; Diuretics; Humans; Hyperparathyroidism; Kidney Calculi; Magnesium; Magnesium Compounds; Oxalates; Penicillamine; Phosphates; Quaternary Ammonium Compounds; Sodium Chloride Symporter Inhibitors; Struvite; Uric Acid | 1980 |
[Urate nephropathy].
Topics: Allopurinol; Gout; Humans; Kidney Calculi; Kidney Diseases; Nephritis, Interstitial; Purines; Uric Acid | 1981 |
Hyperuricemia and gout.
Topics: Allopurinol; Arthritis; Aspirin; Colchicine; Diuretics; Gout; Gout Suppressants; Humans; Indomethacin; Phenylbutazone; Uric Acid | 1982 |
Hyperleukocytic leukemias: rheological, clinical, and therapeutic considerations.
Topics: Adolescent; Allopurinol; Antineoplastic Agents; Blood Flow Velocity; Blood Viscosity; Cerebrovascular Circulation; Child; Child, Preschool; Exchange Transfusion, Whole Blood; Hematocrit; Humans; Hyperkalemia; Leukapheresis; Leukemia; Leukocyte Count; Leukocytosis; Microcirculation; Oxygen Consumption; Pulmonary Circulation; Uric Acid | 1982 |
Renal hypouricemia: prevention of exercise-induced acute renal failure and a review of the literature.
Topics: Acute Kidney Injury; Adult; Allopurinol; Exercise; Exercise Test; Humans; Japan; Male; Uric Acid | 1995 |
Urate and calcium oxalate stones: from repute to rhetoric to reality.
Topics: Allopurinol; Calcium Oxalate; Glycosaminoglycans; Gout; Humans; Hydrogen-Ion Concentration; Hyperoxaluria; Kidney Calculi; Uric Acid; Urinary Calculi | 1994 |
Uric acid nephrolithiasis.
Topics: Allopurinol; Diet; Humans; Kidney; Kidney Calculi; Models, Biological; Purines; Uric Acid; Urinary Calculi; Water-Electrolyte Balance | 1994 |
Diagnosis, prevention, and treatment of urate urolithiasis in Dalmatians.
Topics: Allopurinol; Animal Feed; Animals; Breeding; Dog Diseases; Dogs; Drinking; Hydrogen-Ion Concentration; Uric Acid; Urinary Calculi; Urine | 1993 |
Acute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphoma.
Topics: Acute Disease; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Blood Urea Nitrogen; Burkitt Lymphoma; Creatinine; Humans; Hyperkalemia; Hypocalcemia; L-Lactate Dehydrogenase; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Phosphates; Renal Insufficiency; Retrospective Studies; Risk Factors; Tumor Lysis Syndrome; Uric Acid | 1993 |
The management of gout.
Topics: Acute Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diet; Gout; Gout Suppressants; Humans; Purines; Steroids; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1996 |
Hyperuricemia and xanthine oxidase in preeclampsia, revisited.
Topics: Female; Humans; Kidney; Pre-Eclampsia; Pregnancy; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1996 |
[Xanthine oxidase (xanthine dehydrogenase)].
Topics: DNA; Humans; Hypoxanthine; Protein Conformation; Reperfusion Injury; Superoxides; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1996 |
[How to select and use urate lowering agents for hyperuricemia].
Topics: Allopurinol; Arthritis, Gouty; Creatinine; Gout Suppressants; Humans; Uric Acid; Uricosuric Agents | 1996 |
[Hyperuricemia and the kidney].
Topics: Acute Kidney Injury; Allopurinol; Gout; Humans; Hydrogen-Ion Concentration; Kidney; Renal Dialysis; Tumor Lysis Syndrome; Uric Acid; Urine | 1996 |
[Inherited disorders of uric acid metabolism--classification, enzymatic- and DNA-diagnosis].
Topics: Adenosine Triphosphate; DNA; Humans; Hypoxanthine Phosphoribosyltransferase; Molecular Probe Techniques; Nucleic Acid Hybridization; Phosphoribosyl Pyrophosphate; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Xanthine Oxidase | 1996 |
[Xanthine oxidase deficiency (hereditary xanthinuria), molybdenum cofactor deficiency].
Topics: Central Nervous System Diseases; Coenzymes; Diagnosis, Differential; Diet Therapy; Humans; Infant, Newborn; Metalloproteins; Molybdenum Cofactors; Pteridines; Purine-Pyrimidine Metabolism, Inborn Errors; Seizures; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1996 |
[Metabolic disorder of purine nucleotide in patients with renal disease].
Topics: Allopurinol; Arthritis, Gouty; Humans; Kidney Diseases; Purine Nucleotides; Uric Acid | 1996 |
[Pharmacological agents affecting uric acid metabolism].
Topics: Allopurinol; Diuretics; Fructose; Gout; Gout Suppressants; Humans; Inosine; Kidney Diseases; Niacin; Purines; Uric Acid; Xylitol | 1996 |
[Management of hyperuricemia in diabetes].
Topics: Allopurinol; Benzbromarone; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Humans; Insulin Resistance; Probenecid; Uric Acid; Uricosuric Agents | 1997 |
Advances in the management of malignancy-associated hyperuricaemia.
Topics: Allopurinol; Antineoplastic Agents; Aspergillus flavus; Gout Suppressants; Humans; Male; Recombinant Proteins; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 1998 |
Regulation of oxidant production in acute lung injury.
Topics: Animals; Gout; Humans; Lung; NADPH Oxidases; Reactive Oxygen Species; Respiratory Distress Syndrome; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1999 |
Gout.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Gout; Gout Suppressants; Humans; Uric Acid | 1998 |
Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient.
Topics: Allopurinol; Drug Hypersensitivity; Gout; Gout Suppressants; Humans; Kidney; Transplantation, Homologous; Uric Acid; Uricosuric Agents | 2001 |
The physiology of endothelial xanthine oxidase: from urate catabolism to reperfusion injury to inflammatory signal transduction.
Topics: Animals; Endothelium, Vascular; Humans; Reperfusion Injury; Signal Transduction; Uric Acid; Vasculitis; Xanthine Oxidase | 2002 |
Asymptomatic hyperuricemia: to treat or not to treat.
Topics: Age Factors; Allopurinol; Cardiovascular Diseases; Clinical Trials as Topic; Gout; Gout Suppressants; Humans; Hypoxanthine Phosphoribosyltransferase; Reference Values; Uric Acid; Urinary Calculi | 2002 |
Hyperuricosuric calcium nephrolithiasis.
Topics: Allopurinol; Calcium Oxalate; Citrates; Female; Gout; Gout Suppressants; Humans; Kidney Calculi; Lithiasis; Male; Uric Acid | 2002 |
[Xanthine dehydrogenase (xanthine oxidase)].
Topics: Allopurinol; Animals; Enzyme Inhibitors; Flavin-Adenine Dinucleotide; Free Radicals; Humans; Hyperuricemia; NAD; Reactive Oxygen Species; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2003 |
[Secondary hyperuricemia in hematologic disease].
Topics: Allopurinol; Enzyme Inhibitors; Hematologic Neoplasms; Humans; Hyperuricemia; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2003 |
[Secondary hyperuricemia in burn and trauma].
Topics: Animals; Burns; Humans; Hyperuricemia; Superoxides; Uric Acid; Wounds and Injuries; Xanthine; Xanthine Oxidase | 2003 |
[Hypouricemia--definition and classification].
Topics: Carrier Proteins; Diagnosis, Differential; Humans; Kidney Tubules; Mutation; Organic Anion Transporters; Organic Cation Transport Proteins; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Oxidase | 2003 |
[Typing of hypouricemia (uric acid clearance)].
Topics: Allopurinol; Creatinine; Humans; Inappropriate ADH Syndrome; Kidney Diseases; Kidney Tubules; Losartan; Metabolic Clearance Rate; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Oxidase | 2003 |
[Primary underproductive hypouricemia].
Topics: Allopurinol; Coenzymes; Diagnosis, Differential; Humans; Liver Diseases; Metalloproteins; Molybdenum Cofactors; Prognosis; Pteridines; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Xanthine | 2003 |
[Blood antioxidant capacity in gout].
Topics: Allopurinol; Animals; Antioxidants; Arteriosclerosis; Enzyme Inhibitors; Free Radical Scavengers; Gout; Humans; Oxidative Stress; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 2003 |
Clinical practice. Gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Diagnosis, Differential; Gout Suppressants; Humans; Male; Middle Aged; Practice Guidelines as Topic; Uric Acid | 2003 |
Hyperuricemia and adverse outcomes in cardiovascular disease: potential for therapeutic intervention.
Topics: Allopurinol; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2003 |
Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase.
Topics: Allopurinol; Amlodipine; Clinical Trials as Topic; Enzyme Inhibitors; Febuxostat; Gout; Humans; Hyperuricemia; Losartan; Pyrazoles; Thiazoles; Treatment Outcome; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2004 |
[Prophylaxis and differential therapy of tumorlysis syndrome].
Topics: Allopurinol; Antimetabolites; Antineoplastic Agents; Cost-Benefit Analysis; Enzyme Inhibitors; Humans; Neoplasms; Risk Factors; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid; Water-Electrolyte Balance | 2004 |
[Purine metabolism in patients with renal failure].
Topics: Allopurinol; Antimetabolites; Glomerulonephritis; Humans; Hyperuricemia; Hypoxanthine; Kidney; Kidney Failure, Chronic; Purines; Renal Dialysis; Uric Acid; Xanthine | 2004 |
Gout: on the brink of novel therapeutic options for an ancient disease.
Topics: Acute Disease; Benzothiadiazines; Diuretics; Female; Gout; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Metabolic Syndrome; Obesity; Postmenopause; Sodium Chloride Symporter Inhibitors; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2004 |
Management of hyperuricemia with rasburicase review.
Topics: Allopurinol; Antimetabolites; Clinical Trials as Topic; Cost-Benefit Analysis; Free Radical Scavengers; Humans; Hyperuricemia; Hypoxanthine; Time Factors; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2004 |
Uric acid in chronic heart failure.
Topics: Allopurinol; Animals; Biomarkers; Blood Flow Velocity; Blood Vessels; Chronic Disease; Disease Progression; Endothelium, Vascular; Enzyme Inhibitors; Heart Failure; Humans; Hyperuricemia; Prognosis; Uric Acid; Xanthine Oxidase | 2005 |
[Hyperuricemia/gout. Main symptoms of arthropathy. Severe acute joint pain, redness, inflammation].
Topics: Allopurinol; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diagnosis, Differential; Glucocorticoids; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Prognosis; Risk Factors; Sex Factors; Time Factors; Treatment Outcome; Uric Acid | 2005 |
The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure.
Topics: Allopurinol; Diuretics; Free Radical Scavengers; Heart Failure; Humans; Kidney; Oxidative Stress; Uric Acid | 2005 |
An update on the treatment options for gout and calcium pyrophosphate deposition.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chondrocalcinosis; Colchicine; Drug Combinations; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Multicenter Studies as Topic; Probenecid; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2005 |
Uric acid and oxidative stress.
Topics: Animals; Antioxidants; Humans; Laparoscopy; Oxidative Stress; Reperfusion Injury; Uric Acid; Xanthine Oxidase | 2005 |
[Hyperuricemia].
Topics: Allopurinol; Coronary Disease; Gout Suppressants; Humans; Hyperuricemia; Risk Factors; Uric Acid | 2005 |
Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeutics.
Topics: Carrier Proteins; Diet; Enzyme Inhibitors; Humans; Hyperuricemia; Kidney; Organic Anion Transporters; Organic Cation Transport Proteins; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2006 |
New developments in clinically relevant mechanisms and treatment of hyperuricemia.
Topics: Febuxostat; Humans; Hyperuricemia; Prognosis; Thiazoles; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2006 |
Therapeutic advances in gout.
Topics: Allopurinol; Feeding Behavior; Gout; Humans; Metabolic Syndrome; Risk Reduction Behavior; Uric Acid; Uricosuric Agents | 2007 |
Updates in the management of gout.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chronic Disease; Colchicine; Drug Therapy, Combination; Family Practice; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Pain Measurement; Prognosis; Risk Assessment; Severity of Illness Index; Treatment Outcome; Uric Acid | 2007 |
Crystal-associated arthritis in the elderly.
Topics: Aged; Allopurinol; Arthritis; Arthritis, Gouty; Calcium Pyrophosphate; Chondrocalcinosis; Comorbidity; Diagnosis, Differential; Glucocorticoids; Gout; Gout Suppressants; Humans; Hyperuricemia; Osteoarthritis; Renal Insufficiency; Uric Acid | 2007 |
[The pathophysiology, clinical signs and therapy of urate nephropathy].
Topics: Acidosis; Acute Kidney Injury; Allopurinol; Fluid Therapy; Humans; Hyperkalemia; Kidney Tubules; Recombinant Proteins; Renal Dialysis; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2007 |
Uricase and other novel agents for the management of patients with treatment-failure gout.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Randomized Controlled Trials as Topic; Recombinant Proteins; Thiazoles; Treatment Failure; Urate Oxidase; Uric Acid | 2007 |
Uric acid reduction: a new paradigm in the management of cardiovascular risk?
Topics: Animals; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Risk Reduction Behavior; Uric Acid; Xanthine Oxidase | 2007 |
Prevention of stone disease.
Topics: Allopurinol; Calcium Oxalate; Cystine; Diet; Dietary Supplements; Drinking; Humans; Life Style; Renal Agents; Secondary Prevention; Sodium Chloride Symporter Inhibitors; Uric Acid; Urinary Calculi; Urolithiasis | 2007 |
Lowering serum uric acid levels: what is the optimal target for improving clinical outcomes in gout?
Topics: Allopurinol; Gout; Humans; Treatment Outcome; Uric Acid | 2007 |
Optimizing therapy with allopurinol: factors limiting hypouricemic efficacy.
Topics: Allopurinol; Antimetabolites; Dose-Response Relationship, Drug; Humans; Oxypurinol; Practice Guidelines as Topic; Practice Patterns, Physicians'; Uric Acid | 2008 |
[Pathophysiology and treatment of secondary hyperuricemia].
Topics: Adenosine Triphosphate; Alcoholism; Allopurinol; Diuretics; Gout Suppressants; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Purine Nucleotides; Renal Insufficiency; Uric Acid | 2008 |
[Establishment of therapeutic goal and plan of gout and asymptomatic hyperuricemia].
Topics: Allopurinol; Benzbromarone; Cardiovascular Diseases; Gout; Gout Suppressants; Humans; Hyperuricemia; Life Style; Patient Care Planning; Practice Guidelines as Topic; Renal Insufficiency; Uric Acid | 2008 |
[Uricosuric agent].
Topics: Allopurinol; Benzbromarone; Gout; Humans; Hyperuricemia; Kidney Tubules, Proximal; Organic Anion Transporters; Organic Cation Transport Proteins; Uric Acid; Uricosuric Agents | 2008 |
The role of urate and xanthine oxidase inhibitors in cardiovascular disease.
Topics: Allopurinol; Animals; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Uric Acid; Xanthine Oxidase | 2008 |
Quality of life and quality of care for patients with gout.
Topics: Allopurinol; Delivery of Health Care; Disability Evaluation; Female; Gout; Gout Suppressants; Health Status; Humans; Male; Medication Errors; Outcome Assessment, Health Care; Practice Guidelines as Topic; Predictive Value of Tests; Quality of Life; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome; Uric Acid | 2009 |
Update on emerging urate-lowering therapies.
Topics: Allopurinol; Drug Discovery; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Thiazoles; United States; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2009 |
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress.
Topics: Allopurinol; Animals; Antioxidants; Endothelium, Vascular; Enzyme Inhibitors; Humans; Myocardium; Oxidative Stress; Oxygen Consumption; Uric Acid; Vascular Diseases; Xanthine Oxidase | 2009 |
Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders?
Topics: Allopurinol; Enzyme Inhibitors; Fatty Liver; Humans; Liver Diseases; Metabolic Syndrome; Mucositis; Renal Insufficiency, Chronic; Reperfusion Injury; Uric Acid; Xanthine Dehydrogenase | 2009 |
Approach to the treatment of hyperuricemia.
Topics: Allopurinol; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Thiazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2009 |
Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout.
Topics: Allopurinol; Biotransformation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Half-Life; Humans; Hyperuricemia; Thiazoles; Tissue Distribution; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2009 |
Diagnosing and treating gout: a review to aid primary care physicians.
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Gout; Gout Suppressants; Humans; Male; Middle Aged; Physicians, Family; Synovial Fluid; Uric Acid | 2010 |
Uric acid and hypertension: cause or effect?
Topics: Allopurinol; Blood Pressure; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Uric Acid | 2010 |
Urate oxidase for the prevention and treatment of tumor lysis syndrome in children with cancer.
Topics: Allopurinol; Antimetabolites; Child; Controlled Clinical Trials as Topic; Humans; Neoplasms; Randomized Controlled Trials as Topic; Renal Insufficiency; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2010 |
Management of gout: beyond allopurinol.
Topics: Allopurinol; Animals; Biomarkers; Disease Management; Gout; Humans; Uric Acid | 2010 |
Gout therapeutics: new drugs for an old disease.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Clinical Trials as Topic; Drug Administration Schedule; Drug Approval; Enzyme Inhibitors; Europe; Febuxostat; Gout; Gout Suppressants; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Fusion Proteins; Thiazoles; United States; United States Food and Drug Administration; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2011 |
Gout: a clinical syndrome illustrated and discussed.
Topics: Aged; Aged, 80 and over; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Risk Factors; United States; Uric Acid | 2010 |
Crystal arthropathies: recognizing and treating "the gouch".
Topics: Allopurinol; Antimetabolites; Chronic Disease; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thiazoles; Uric Acid; Uricosuric Agents | 2010 |
Uric acid in hypertension and renal disease: the chicken or the egg?
Topics: Allopurinol; Animals; Blood Pressure; Clinical Trials as Topic; Diet; Disease Progression; Fructose; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Mice; Rats; Risk Factors; Uric Acid | 2010 |
Serum uric acid as a new player in the development of diabetic nephropathy.
Topics: Allopurinol; Animals; Antimetabolites; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Models, Animal; Humans; Rats; Uric Acid | 2011 |
Role of melanocortin receptors in the regulation of gouty inflammation.
Topics: Allopurinol; Animals; Arthritis, Gouty; Colchicine; Crystallization; Disease Models, Animal; Gout Suppressants; Humans; Injections, Intra-Articular; Melanocortins; Mice; Receptors, Melanocortin; Uric Acid | 2011 |
Hypouricemia and tubular transport of uric acid.
Topics: Absorption; Biological Transport; Diabetes Complications; Diagnosis, Differential; Fluid Therapy; Glucose Transport Proteins, Facilitative; Humans; Kidney Tubules, Proximal; Models, Biological; Organic Anion Transporters; Organic Cation Transport Proteins; Prevalence; Renal Tubular Transport, Inborn Errors; Uric Acid; Urinary Calculi; Xanthine; Xanthine Oxidase | 2011 |
Clinical practice. Gout.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Risk Factors; Uric Acid | 2011 |
Challenges of conducting a trial of uric-acid-lowering therapy in CKD.
Topics: Allopurinol; Gout Suppressants; Humans; Hyperuricemia; Kidney Failure, Chronic; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Uric Acid | 2011 |
[Treatment of gout].
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Thiazoles; Uric Acid; Uricosuric Agents | 2011 |
Allopurinol, uric acid, and oxidative stress in cardiorenal disease.
Topics: Allopurinol; Animals; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Hyperuricemia; Oxidative Stress; Renal Insufficiency, Chronic; Uric Acid | 2011 |
[Febuxostat].
Topics: Allopurinol; Enzyme Activation; Febuxostat; Gout; Gout Suppressants; Humans; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid; Xanthine Oxidase | 2011 |
A new standard of care? Studies on febuxostat in the management of hyperuricemia with and without gout.
Topics: Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Primary Health Care; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2011 |
[Gout - regardless of therapeutic options a "forgotten" disease].
Topics: Allopurinol; Arthritis, Gouty; Benzbromarone; Combined Modality Therapy; Cytokines; Europe; Febuxostat; Gout; Gout Suppressants; Guideline Adherence; Humans; Inflammasomes; Interleukin-1; Long-Term Care; Probenecid; Signal Transduction; Thiazoles; Uric Acid | 2011 |
[The role of uric acid in heart failure].
Topics: Animals; Biomarkers; Chronic Disease; Heart Failure; Humans; Oxidative Stress; Uric Acid; Xanthine Oxidase | 2011 |
Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease?
Topics: Cardiovascular Diseases; Humans; Hyperuricemia; Losartan; Risk Factors; Uric Acid; Xanthine Oxidase | 2006 |
Clinical inquiry. Are serum uric acid levels always elevated in acute gout?
Topics: Acute Disease; Allopurinol; Arthritis, Gouty; Biomarkers; Gout; Gout Suppressants; Humans; Hyperuricemia; Practice Guidelines as Topic; Uric Acid | 2011 |
Xanthine oxidase and uric acid in cardiovascular disease: clinical impact and therapeutic options.
Topics: Biomarkers; Cardiovascular Diseases; Heart Failure; Humans; Hyperuricemia; Reactive Oxygen Species; Severity of Illness Index; Uric Acid; Xanthine Oxidase | 2011 |
Recent advances in management of gout.
Topics: Adrenal Cortex Hormones; Alcohol Drinking; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Ascorbic Acid; Colchicine; Comorbidity; Cryotherapy; Diet; Dose-Response Relationship, Drug; Febuxostat; Fructose; Gout; Gout Suppressants; Humans; Interleukin 1 Receptor Antagonist Protein; Polyethylene Glycols; Purines; Receptors, Interleukin-1; Recombinant Fusion Proteins; Thiazoles; Urate Oxidase; Uric Acid; Uricosuric Agents; Vitamins; Xanthine Oxidase | 2012 |
Diagnosis and treatment of gout in primary care.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Gout; Gout Suppressants; Humans; Primary Health Care; Risk Factors; Secondary Prevention; Uric Acid | 2011 |
Relationships among hyperuricemia, endothelial dysfunction and cardiovascular disease: molecular mechanisms and clinical implications.
Topics: Allopurinol; Antioxidants; Atherosclerosis; Cardiovascular Diseases; Endothelium, Vascular; Humans; Hyperuricemia; Molecular Targeted Therapy; Oxidative Stress; Oxypurinol; Reactive Oxygen Species; Risk Factors; Uric Acid; Xanthine Dehydrogenase | 2012 |
[Gout: an overview of available urate lowering therapies].
Topics: Allopurinol; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Guidelines as Topic; Humans; Organ Transplantation; Polyethylene Glycols; Thiazoles; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2012 |
The genetics of hyperuricaemia and gout.
Topics: Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Glucose Transport Proteins, Facilitative; Gout; Gout Suppressants; Humans; Hyperuricemia; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transport Proteins; Uric Acid | 2012 |
Uric acid as a target of therapy in CKD.
Topics: Disease Progression; Humans; Hyperuricemia; Predictive Value of Tests; Renal Insufficiency, Chronic; Uric Acid; Xanthine Oxidase | 2013 |
Safety of urate-lowering therapies: managing the risks to gain the benefits.
Topics: Allopurinol; Comorbidity; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Risk Factors; Thiazoles; Uric Acid | 2012 |
Novel drug discovery strategies for gout.
Topics: Drug Discovery; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2013 |
Efficacy and tolerability of febuxostat in hyperuricemic patients with or without gout: a systematic review and meta-analysis.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid | 2013 |
Efficacy and cost of single-dose rasburicase in prevention and treatment of adult tumour lysis syndrome: a meta-analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Female; Humans; Hyperuricemia; Middle Aged; Prospective Studies; Retrospective Studies; Tumor Lysis Syndrome; United States; United States Food and Drug Administration; Urate Oxidase; Uric Acid; Young Adult | 2013 |
Uric acid lowering to prevent kidney function loss in diabetes: the preventing early renal function loss (PERL) allopurinol study.
Topics: Allopurinol; Clinical Trials as Topic; Diabetic Nephropathies; Humans; Kidney; Kidney Function Tests; Uric Acid | 2013 |
Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis.
Topics: Allopurinol; Disease Progression; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uric Acid | 2014 |
A systematic review and meta-analysis on the safety and efficacy of febuxostat versus allopurinol in chronic gout.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Thiazoles; Treatment Outcome; Uric Acid | 2013 |
Uric acid and xanthine oxidoreductase in wound healing.
Topics: Allopurinol; Chronic Disease; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Humans; Inflammation; Uric Acid; Varicose Ulcer; Wound Healing; Xanthine Dehydrogenase | 2014 |
Oxidative stress and endothelial dysfunction: clinical evidence and therapeutic implications.
Topics: Animals; Bilirubin; Endothelium, Vascular; Gilbert Disease; Humans; Hypertension, Renovascular; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Uric Acid; Xanthine Oxidase | 2014 |
Serum uric acid and the risk of hypertension and chronic kidney disease.
Topics: Animals; Biomarkers; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hypertension; Hyperuricemia; Renal Insufficiency, Chronic; Risk Factors; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
Uricosuric drugs: the once and future therapy for hyperuricemia?
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Discovery; Enzyme Inhibitors; Glucose Transport Proteins, Facilitative; Gout; Humans; Hydrochlorothiazide; Hyperuricemia; Kidney Tubules, Proximal; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transport Proteins; Probenecid; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
Gout.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Colchicine; Comorbidity; Gout; Gout Suppressants; Humans; Male; Middle Aged; Patient Education as Topic; Risk Reduction Behavior; Toe Joint; Uric Acid | 2013 |
Multiple firm nodules and tender, indurated plaques.
Topics: Adult; Allopurinol; Biopsy, Needle; Diagnosis, Differential; Follow-Up Studies; Gout; Humans; Immunohistochemistry; Male; Panniculitis; Rare Diseases; Risk Assessment; Severity of Illness Index; Skin; Skin Diseases; Treatment Outcome; Uric Acid | 2014 |
Treatment of calcium nephrolithiasis in the patient with hyperuricosuria.
Topics: Allopurinol; Biomarkers; Calcium Oxalate; Febuxostat; Humans; Indapamide; Kidney; Nephrolithiasis; Risk Factors; Treatment Outcome; Uric Acid; Uricosuric Agents | 2014 |
A review of phytotherapy of gout: perspective of new pharmacological treatments.
Topics: Animals; Anti-Inflammatory Agents; Gout; Humans; Hyperuricemia; Phytotherapy; Plants, Medicinal; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
The role of uric acid in kidney fibrosis: experimental evidences for the causal relationship.
Topics: Animals; Disease Models, Animal; Fibrosis; Humans; Inflammation; Renal Insufficiency, Chronic; Uric Acid; Xanthine Oxidase | 2014 |
Allopurinol as a kidney-protective, cardioprotective, and antihypertensive agent: hype or reality?
Topics: Allopurinol; Antihypertensive Agents; Cardiotonic Agents; Chronic Disease; Coronary Disease; Gout Suppressants; Humans; Hypertension, Renal; Randomized Controlled Trials as Topic; Uric Acid | 2014 |
Impaired response or insufficient dosage? Examining the potential causes of "inadequate response" to allopurinol in the treatment of gout.
Topics: Allopurinol; Biomarkers; Dose-Response Relationship, Drug; Gout; Gout Suppressants; Humans; Patient Compliance; Treatment Failure; Uric Acid | 2014 |
Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer.
Topics: Adolescent; Allopurinol; Antimetabolites; Area Under Curve; Child; Controlled Clinical Trials as Topic; Humans; Neoplasms; Randomized Controlled Trials as Topic; Renal Insufficiency; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2014 |
Hyperuricemia and cardiovascular disease risk.
Topics: Cardiovascular Diseases; Humans; Hyperuricemia; Risk Factors; Uric Acid; Xanthine Oxidase | 2014 |
Aggravation of immunoglobulin a nephropathy by hyperuricemia: a mini-review on current findings and new concepts.
Topics: Allopurinol; Disease Progression; Glomerulonephritis, IGA; Gout Suppressants; Humans; Hyperuricemia; Kidney; Kidney Failure, Chronic; Risk Factors; Treatment Outcome; Uric Acid | 2014 |
Allopurinol for chronic gout.
Topics: Allopurinol; Benzbromarone; Chronic Disease; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Probenecid; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid | 2014 |
Uricosuric medications for chronic gout.
Topics: Adult; Aged; Allopurinol; Benzbromarone; Chronic Disease; Controlled Clinical Trials as Topic; Female; Gout; Humans; Male; Middle Aged; Probenecid; Randomized Controlled Trials as Topic; Uric Acid; Uricosuric Agents | 2014 |
Managing gout: there's more we can do.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Age Distribution; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Disease Progression; Early Diagnosis; Female; Gout; Gout Suppressants; Humans; Incidence; Male; Middle Aged; Needs Assessment; Practice Guidelines as Topic; Prognosis; Risk Assessment; Severity of Illness Index; Sex Distribution; Treatment Outcome; United States; Uric Acid | 2014 |
Medical and dietary therapy for kidney stone prevention.
Topics: Allopurinol; Calcium Oxalate; Cystine; Diet; Humans; Kidney Calculi; Potassium Citrate; Sodium Chloride Symporter Inhibitors; Uric Acid; Urological Agents | 2014 |
Safety of allopurinol compared with other urate-lowering drugs in patients with gout: a systematic review and meta-analysis.
Topics: Allopurinol; Biomarkers; Down-Regulation; Gout; Gout Suppressants; Humans; Hyperuricemia; Odds Ratio; Risk Factors; Treatment Outcome; Uric Acid | 2015 |
Advances in pharmacotherapy for the treatment of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzbromarone; Clinical Trials, Phase III as Topic; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Polyethylene Glycols; Probenecid; Thiazoles; Urate Oxidase; Uric Acid | 2015 |
Uric acid as a biomarker and a therapeutic target in diabetes.
Topics: Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diabetic Nephropathies; Enzyme Inhibitors; Humans; Oxidative Stress; Risk Factors; Uric Acid; Xanthine Oxidase | 2015 |
Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.
Topics: Aged; Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biomarkers; California; Cell Survival; Dose-Response Relationship, Drug; Female; Gene Frequency; Genome-Wide Association Study; Genotype; Gout Suppressants; HEK293 Cells; Humans; Hyperuricemia; Male; Middle Aged; Mitoxantrone; Neoplasm Proteins; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide; Transfection; Treatment Outcome; Uric Acid | 2015 |
Pharmacogenetic considerations in the treatment of gout.
Topics: Allopurinol; Gout; HLA-B Antigens; Humans; Pharmacogenetics; Treatment Outcome; Uric Acid | 2015 |
[A model-based meta-analysis to compare urate-lowering response rate of febuxostat and allopurinol in gout patient].
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Thiazoles; Uric Acid | 2014 |
Dispelling dogma and misconceptions regarding the most pharmacologically targetable source of reactive species in inflammatory disease, xanthine oxidoreductase.
Topics: Allopurinol; Animals; Humans; Inflammation; Nitric Oxide; Reactive Oxygen Species; Uric Acid; Xanthine Dehydrogenase | 2015 |
[Serum uric acid reference values: clinical nonsense as a measure of quality].
Topics: Allopurinol; Gout; Humans; Male; Medication Adherence; Middle Aged; Quality Indicators, Health Care; Reference Values; Uric Acid | 2015 |
[The role of uric acid and allopurinol therapy in cardiovascular disease].
Topics: Allopurinol; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Hyperuricemia; Uric Acid | 2015 |
Uric acid and xanthine oxidase in heart failure - Emerging data and therapeutic implications.
Topics: Heart Failure; Humans; Prognosis; Reactive Oxygen Species; Risk Factors; Uric Acid; Xanthine Oxidase | 2016 |
Uric acid lowering therapy in cardiovascular diseases.
Topics: Cardiovascular Diseases; Enzyme Inhibitors; Gout; Gout Suppressants; Humans; Hyperuricemia; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2016 |
Treatment of patients with uric acid stones.
Topics: Allopurinol; Bicarbonates; Diet; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Uric Acid | 2016 |
Urate lowering therapies in the treatment of gout: a systematic review and meta-analysis.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Treatment Outcome; Uric Acid | 2016 |
Low acid uric in primary prophylaxis: worthy?
Topics: Allopurinol; Cardiovascular Diseases; Early Diagnosis; Humans; Oxypurinol; Primary Prevention; Risk Factors; Treatment Failure; Uric Acid | 2016 |
Gouty Arthritis: A Review of Acute Management and Prevention.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Gout; Humans; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2016 |
Pathogenesis and Clinical Management of Gouty Arthritis.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Gouty; Colchicine; Diet, Healthy; Febuxostat; Fluid Therapy; Gout Suppressants; Humans; Hyperuricemia; Inflammation; Interleukin 1 Receptor Antagonist Protein; Polyethylene Glycols; Smoking Cessation; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2015 |
Effect of uric acid-lowering therapy on blood pressure: systematic review and meta-analysis.
Topics: Adolescent; Aged; Allopurinol; Antihypertensive Agents; Blood Pressure; Creatinine; Enzyme Inhibitors; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome; Uric Acid | 2017 |
Xanthine oxidoreductase and its inhibitors: relevance for gout.
Topics: Allopurinol; Animals; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Hypoxanthine; Uric Acid; Xanthine Dehydrogenase | 2016 |
Allopurinol as a therapeutic option in cardiovascular disease.
Topics: Allopurinol; Animals; Cardiovascular Diseases; Enzyme Inhibitors; Free Radical Scavengers; Humans; Hyperuricemia; Myocardial Reperfusion Injury; Oxidative Stress; Risk Factors; Uric Acid; Xanthine Oxidase | 2017 |
Major unanswered questions in the clinical gout field.
Topics: Allopurinol; Benzbromarone; Colchicine; Disease Progression; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Patient Care Planning; Probenecid; Renal Insufficiency, Chronic; Uric Acid; Uricosuric Agents | 2017 |
Allopurinol: insights from studies of dose-response relationships.
Topics: Allopurinol; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Medication Adherence; Renal Insufficiency; Treatment Outcome; Uric Acid | 2017 |
Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.
Topics: Animals; Atherosclerosis; Disease Progression; Free Radicals; Heart Failure; Humans; Inflammasomes; Inflammation; Metabolic Syndrome; Mice; Non-alcoholic Fatty Liver Disease; Superoxides; Uric Acid; Xanthine Oxidase | 2016 |
An evidence-based review on urate-lowering treatments: implications for optimal treatment of chronic hyperuricemia.
Topics: Antioxidants; Biomarkers; Chronic Disease; Down-Regulation; Enzyme Inhibitors; Evidence-Based Medicine; Humans; Hyperuricemia; Oxidative Stress; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2017 |
Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer.
Topics: Adolescent; Allopurinol; Antimetabolites; Area Under Curve; Child; Controlled Clinical Trials as Topic; Humans; Neoplasms; Randomized Controlled Trials as Topic; Renal Insufficiency; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2017 |
Lesinurad: A Review in Hyperuricaemia of Gout.
Topics: Adult; Allopurinol; Drug Therapy, Combination; Enzyme Inhibitors; Febuxostat; Gout; Humans; Hyperuricemia; Kidney; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2017 |
The genetics of gout: towards personalised medicine?
Topics: Allopurinol; Genome-Wide Association Study; Gout; Gout Suppressants; Humans; Hyperuricemia; Life Style; Precision Medicine; Prognosis; Uric Acid | 2017 |
Updates on the treatment of gout, including a review of updated treatment guidelines and use of small molecule therapies for difficult-to-treat gout and gout flares.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Gout; Gout Suppressants; Humans; Practice Guidelines as Topic; Severity of Illness Index; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2017 |
Can Serum Uric Acid Lowering Therapy Contribute to the Prevention or Treatment of Nonalcoholic Fatty Liver Disease?
Topics: Allopurinol; Atorvastatin; Biomarkers; Gout Suppressants; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperuricemia; Non-alcoholic Fatty Liver Disease; Prevalence; Risk Factors; Treatment Outcome; Uric Acid | 2018 |
Effect of allopurinol and uric acid normalization on serum lipids hyperuricemic subjects: A systematic review with meta-analysis.
Topics: Allopurinol; Humans; Hyperuricemia; Lipids; Randomized Controlled Trials as Topic; Time Factors; Uric Acid | 2017 |
Potency on lowering serum uric acid in gout patients: a pooled analysis of registrative studies comparing febuxostat vs. allopurinol.
Topics: Adult; Allopurinol; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Randomized Controlled Trials as Topic; Treatment Outcome; Uric Acid | 2017 |
The Effect of Xanthine Oxidase Inhibitors on Blood Pressure and Renal Function.
Topics: Allopurinol; Blood Pressure; Enzyme Inhibitors; Febuxostat; Glomerular Filtration Rate; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2017 |
Effects of Allopurinol on Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
Topics: Allopurinol; Cardiovascular Diseases; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Randomized Controlled Trials as Topic; Uric Acid; Vasodilation | 2018 |
[Research progress of puerarin and its derivatives on anti-inflammatory and anti-gout activities].
Topics: Anti-Inflammatory Agents; Gout; Gout Suppressants; Humans; Isoflavones; Uric Acid; Xanthine Oxidase | 2017 |
Hyperuricosuric calcium urolithiasis.
Topics: Allopurinol; Calcium Oxalate; Chemical Phenomena; Gout Suppressants; Humans; Hypercalciuria; Risk Factors; Uric Acid; Urolithiasis | 2018 |
Uric Acid: The Unknown Uremic Toxin.
Topics: Allopurinol; Febuxostat; Glomerular Filtration Rate; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Kidney; Parenchymal Tissue; Renal Insufficiency, Chronic; Uric Acid | 2018 |
Time to Target Uric Acid to Retard Chronic Kidney Disease Progression.
Topics: Allopurinol; Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily G, Member 2; Disease Progression; Enzyme Inhibitors; Febuxostat; Glucosides; Gout Suppressants; Humans; Hyperuricemia; Monosaccharide Transport Proteins; Nitriles; Oxidative Stress; Pyridines; Renal Insufficiency, Chronic; Risk Factors; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Uric Acid; Xanthine Oxidase | 2018 |
Uric Acid and Diabetic Nephropathy Risk.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Progression; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Risk Factors; Uric Acid | 2018 |
Gout: state of the art after a decade of developments.
Topics: Allopurinol; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2019 |
Uric acid and progression of chronic kidney disease.
Topics: Age Factors; Allopurinol; Animals; Child; Diet Therapy; Disease Models, Animal; Disease Progression; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Observational Studies as Topic; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid | 2019 |
Hyperuricemia and endothelial function: From molecular background to clinical perspectives.
Topics: Antioxidants; Atherosclerosis; Cardiovascular Diseases; Catalysis; Endothelium, Vascular; Humans; Hyperuricemia; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Purines; Reactive Oxygen Species; Risk Factors; Superoxides; Uric Acid; Xanthine Oxidase | 2018 |
Gout - An update of aetiology, genetics, co-morbidities and management.
Topics: Allopurinol; Chronic Disease; Comorbidity; Diet; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thioglycolates; Triazoles; Uric Acid | 2018 |
The Challenges of Approaching and Managing Gout.
Topics: Acetamides; Allopurinol; Antibodies, Monoclonal, Humanized; Colchicine; Diet Therapy; Febuxostat; Gout; Gout Suppressants; Humans; Medication Adherence; Patient Education as Topic; Phenylacetates; Polyethylene Glycols; Quality of Health Care; Rheumatology; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid | 2019 |
Genetic advances in gout: potential applications in clinical practice.
Topics: Allopurinol; Disease Progression; Genome-Wide Association Study; Gout; Gout Suppressants; HLA-B Antigens; Humans; Uric Acid | 2019 |
Potential Dangers of Serum Urate-Lowering Therapy.
Topics: Cardiovascular Diseases; Gout Suppressants; Humans; Oxidative Stress; Polyethylene Glycols; Thioglycolates; Triazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2019 |
Uric acid and hypertension: a focused review and practical recommendations.
Topics: Animals; Antioxidants; Blood Pressure; Enzyme Inhibitors; Humans; Hypertension; Hyperuricemia; Kidney; Kidney Diseases; Oxidative Stress; Risk Factors; Uric Acid; Urogenital Abnormalities; Xanthine Oxidase | 2019 |
Rare Manifestation of Gout: Gouty Tophi in the Nose.
Topics: Allopurinol; Biopsy, Needle; Gout; Humans; Immunohistochemistry; Male; Middle Aged; Nasal Cavity; Nasal Obstruction; Nose; Prognosis; Risk Assessment; Tomography, X-Ray Computed; Treatment Outcome; Uric Acid | 2019 |
Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy.
Topics: Allopurinol; Anti-Inflammatory Agents; Cardiovascular Diseases; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid | 2019 |
Safety and tolerability of available urate-lowering drugs: a critical review.
Topics: Enzyme Inhibitors; Gout; Gout Suppressants; Humans; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2019 |
Febuxostat administration for the prevention of tumour lysis syndrome: A meta-analysis.
Topics: Allopurinol; Animals; Febuxostat; Gout Suppressants; Humans; Tumor Lysis Syndrome; Uric Acid | 2019 |
Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
.
Topics: Bayes Theorem; Drug Therapy, Combination; Gout; Humans; Network Meta-Analysis; Randomized Controlled Trials as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2019 |
Natural products for the management of hyperuricaemia and gout: a review.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Asteraceae; Biological Products; Double-Blind Method; Gout; Humans; Hyperuricemia; Inflammation; Mice; Placebos; Plant Extracts; Randomized Controlled Trials as Topic; Risk Factors; Tabebuia; Uric Acid; Xanthine Oxidase | 2021 |
The net clinical benefits of febuxostat versus allopurinol in patients with gout or asymptomatic hyperuricemia - A systematic review and meta-analysis.
Topics: Aged; Allopurinol; Asymptomatic Diseases; Biomarkers; Enzyme Inhibitors; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2019 |
Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016-2019).
Topics: Animals; Drug Development; Humans; Hyperuricemia; Organic Anion Transporters; Organic Cation Transport Proteins; Patents as Topic; Uric Acid; Xanthine Oxidase | 2019 |
Free radicals and neonatal encephalopathy: mechanisms of injury, biomarkers, and antioxidant treatment perspectives.
Topics: Acetylcysteine; Allopurinol; Animals; Antioxidants; Asphyxia Neonatorum; Biomarkers; Brain Injuries; Clinical Trials as Topic; DNA; Erythropoietin; Free Radicals; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Malondialdehyde; Melatonin; Nitric Oxide; Oxidative Stress; Prostaglandins; Proteins; Uric Acid | 2020 |
Effects of allopurinol pretreatment on the risk of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled trials
.
Topics: Acute Kidney Injury; Allopurinol; Contrast Media; Coronary Angiography; Creatinine; Enzyme Inhibitors; Glomerular Filtration Rate; Humans; Percutaneous Coronary Intervention; Preoperative Care; Randomized Controlled Trials as Topic; Risk Factors; Uric Acid | 2020 |
Hyperuricemia: a novel old disorder-relationship and potential mechanisms in heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Cardiovascular Diseases; Disease Progression; Gout; Gout Suppressants; Heart Failure; Humans; Hyperuricemia; Protease Inhibitors; Randomized Controlled Trials as Topic; Sodium-Glucose Transporter 2 Inhibitors; Uric Acid; Xanthine Oxidase | 2020 |
Beyond urate lowering: Analgesic and anti-inflammatory properties of allopurinol.
Topics: Allopurinol; Analgesics; Anti-Inflammatory Agents; Enzyme Inhibitors; Free Radical Scavengers; Gout; Gout Suppressants; Humans; Oxidative Stress; Uric Acid; Xanthine Oxidase | 2020 |
Management of hyperuricemia in asymptomatic patients: A critical appraisal.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Hyperuricemia; Uric Acid | 2020 |
Effect of Uric Acid-Lowering Agents on Cardiovascular Outcome in Patients With Heart Failure: A Systematic Review and Meta-Analysis of Clinical Studies.
Topics: Allopurinol; Enzyme Inhibitors; Febuxostat; Heart Failure; Humans; Oxypurinol; Uric Acid; Xanthine Oxidase | 2020 |
Cardiovascular events in hyperuricemia population and a cardiovascular benefit-risk assessment of urate-lowering therapies: a systematic review and meta-analysis.
Topics: Allopurinol; Cardiovascular Diseases; Febuxostat; Humans; Hyperuricemia; Risk Assessment; Uric Acid | 2020 |
Recent approaches to gout drug discovery: an update.
Topics: Allopurinol; Arthritis, Gouty; Drug Discovery; Gout; Gout Suppressants; Humans; Hyperuricemia; Uric Acid | 2020 |
Efficacy and safety of urate-lowering treatments in patients with hyperuricemia: A comprehensive network meta-analysis of randomized controlled trials.
Topics: Allopurinol; Bayes Theorem; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Network Meta-Analysis; Randomized Controlled Trials as Topic; Uric Acid | 2020 |
Comparative effect of allopurinol and febuxostat on long-term renal outcomes in patients with hyperuricemia and chronic kidney disease: a systematic review.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Renal Insufficiency, Chronic; Retrospective Studies; Treatment Outcome; Uric Acid | 2020 |
Uric Acid Elevation by Favipiravir, an Antiviral Drug.
Topics: Aldehyde Oxidase; Amides; Antiviral Agents; Biotransformation; Coronavirus Infections; COVID-19; Drug Interactions; Humans; Hyperuricemia; Kidney; Kidney Diseases; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Pandemics; Pneumonia, Viral; Pyrazines; Uric Acid; Xanthine Oxidase | 2020 |
Targeting Xanthine Oxidase by Natural Products as a Therapeutic Approach for Mental Disorders.
Topics: Allopurinol; Biological Products; Humans; Mental Disorders; Uric Acid; Xanthine Oxidase | 2021 |
Changing paradigms in the management of gout.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Uric Acid | 2020 |
Comparison of efficacy and safety of urate-lowering therapies for hyperuricemic patients with gout: a meta-analysis of randomized, controlled trials.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Treatment Outcome; Uric Acid | 2021 |
The Association of Febuxostat Compared With Allopurinol on Blood Pressure and Major Adverse Cardiac Events Among Adult Patients With Hyperuricemia: A Meta-analysis.
Topics: Aged; Allopurinol; Biomarkers; Blood Pressure; Febuxostat; Female; Gout Suppressants; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Treatment Outcome; Uric Acid | 2020 |
Cardiovascular safety risks associated with gout treatments.
Topics: Allopurinol; Animals; Cardiovascular Diseases; Colchicine; Gout; Gout Suppressants; Heart Disease Risk Factors; Humans; Uric Acid | 2020 |
Xanthine oxidase inhibitors: patent landscape and clinical development (2015-2020).
Topics: Animals; Drug Development; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Patents as Topic; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 2020 |
Harnessing hyperuricemia to atherosclerosis and understanding its mechanistic dependence.
Topics: Atherosclerosis; Endothelial Cells; Humans; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2021 |
Network Meta-Analysis of Drug Therapies for Lowering Uric Acid and Mortality Risk in Patients with Heart Failure.
Topics: Allopurinol; Gout Suppressants; Heart Failure; Humans; Hyperuricemia; Network Meta-Analysis; Uric Acid | 2021 |
Gout: Rapid Evidence Review.
Topics: Adrenal Cortex Hormones; Allopurinol; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Obesity; Risk Factors; Sex Factors; Uric Acid | 2020 |
Xanthine oxidoreductase: One enzyme for multiple physiological tasks.
Topics: Humans; Nitric Oxide; Oxidation-Reduction; Reactive Oxygen Species; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2021 |
Effectiveness of Allopurinol in Reducing Mortality: Time-Related Biases in Observational Studies.
Topics: Allopurinol; Bias; Cause of Death; Gout; Gout Suppressants; Humans; Hyperuricemia; Mortality; Observational Studies as Topic; Proportional Hazards Models; Time Factors; Uric Acid | 2021 |
The association between urate-lowering therapies and treatment-related adverse events, liver damage, and major adverse cardiovascular events (MACE): A network meta-analysis of randomized trials.
Topics: Allopurinol; Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Network Meta-Analysis; Randomized Controlled Trials as Topic; Uric Acid | 2021 |
The major cardiovascular events of febuxostat versus allopurinol in treating gout or asymptomatic hyperuricemia: a systematic review and meta-analysis.
Topics: Allopurinol; Cardiovascular Diseases; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Treatment Outcome; Uric Acid | 2021 |
Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis.
Topics: Animals; Atherosclerosis; Comorbidity; Diabetes Mellitus, Type 2; Gout; Humans; Hypertension; Hyperuricemia; Metabolic Syndrome; Oxidative Stress; Reactive Oxygen Species; Renal Insufficiency, Chronic; Risk Factors; Uric Acid; Xanthine Oxidase | 2021 |
What's new on the front-line of gout pharmacotherapy?
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Quality of Life; Uric Acid | 2022 |
The Effect of Allopurinol on Renal Outcomes in Patients with Diabetic Kidney Disease: A Systematic Review and Meta-Analysis.
Topics: Albuminuria; Allopurinol; Diabetes Mellitus; Diabetic Nephropathies; Female; Humans; Kidney; Male; Uric Acid | 2022 |
Enhancing the Response Rate to Recombinant Uricases in Patients with Gout.
Topics: Allopurinol; Antibodies; Gout; Gout Suppressants; Humans; Urate Oxidase; Uric Acid | 2022 |
Does seasonality of the microbiota contribute to the seasonality of acute gout flare?
Topics: Arthritis, Gouty; Gout; Gout Suppressants; Humans; Hyperuricemia; Microbiota; Symptom Flare Up; Uric Acid; Xanthine Oxidase | 2022 |
Update on Uric Acid and the Kidney.
Topics: Allopurinol; Female; Gout; Gout Suppressants; Humans; Kidney; Male; Parkinson Disease; Renal Insufficiency, Chronic; Uric Acid | 2022 |
Efficacy of Urate-Lowering Therapy in Patients With Chronic Kidney Disease: A Network Meta-Analysis of Randomized Controlled Trials.
Topics: Allopurinol; Bayes Theorem; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Network Meta-Analysis; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid | 2022 |
Oxygenation of the newborn. The impact of one molecule on newborn lives.
Topics: Female; Humans; Hypoxanthine; Hypoxanthines; Hypoxia; Infant; Infant, Newborn; Oxygen; Pregnancy; Uric Acid; Xanthine Oxidase | 2023 |
Effects of allopurinol on renal function in patients with diabetes: a systematic review and meta-analysis.
Topics: Allopurinol; Diabetes Mellitus; Gout; Gout Suppressants; Humans; Hyperuricemia; Kidney; Uric Acid | 2022 |
Research Progress of Natural Active Substances with Uric-Acid-Reducing Activity.
Topics: Allopurinol; Febuxostat; Humans; Hyperuricemia; Kidney; Uric Acid; Xanthine Oxidase | 2022 |
Effect of nanoparticles on gouty arthritis: a systematic review and meta-analysis.
Topics: Allopurinol; Animals; Arthritis, Gouty; Nanoparticles; Uric Acid | 2023 |
Interventions designed to improve uptake of allopurinol for gout treatment in Aotearoa New Zealand: a scoping review.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; New Zealand; Quality of Life; Uric Acid | 2023 |
[Hyperuricemia and kidney damage in patients with cardiovascular disease: A review].
Topics: Allopurinol; Cardiovascular Diseases; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Kidney; Renal Insufficiency, Chronic; Uric Acid | 2023 |
Mechanisms and rationale for uricase use in patients with gout.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Hyperuricemia; Quality of Life; Urate Oxidase; Uric Acid | 2023 |
Agents for the Treatment of Gout: Current Advances and Future Perspectives.
Topics: Gout; Gout Suppressants; Humans; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2023 |
241 trial(s) available for uric acid and allopurinol
| Article | Year |
|---|---|
X-linked recessive (Duchenne) muscular dystrophy (DMD) and purine metabolism: effects of oral allopurinol and adenylate.
Topics: Adenosine Monophosphate; Administration, Oral; Adolescent; Allopurinol; Child; Child, Preschool; Clinical Trials as Topic; Creatine Kinase; Double-Blind Method; Electrocardiography; Female; gamma-Glutamyltransferase; Genes, Recessive; Humans; Liver; Male; Manometry; Muscle Contraction; Muscles; Muscular Dystrophies; Purines; Sex Chromosome Aberrations; Uric Acid; X Chromosome | 1978 |
Double blind controlled comparison of aspirin, allopurinol and placebo in the management of arthralgia during pyrazinamide administration.
Topics: Adolescent; Adult; Aged; Allopurinol; Aspirin; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Joint Diseases; Male; Middle Aged; Pain; Pyrazinamide; Random Allocation; Time Factors; Tuberculosis, Pulmonary; Uric Acid | 1979 |
Studies on tienilic acid in hypertensive hyperuricaemic patients in Dunedin, New Zealand.
Topics: Aged; Allopurinol; Clinical Trials as Topic; Cyclopenthiazide; Diuretics; Drug Therapy, Combination; Female; Glycolates; Humans; Hypertension; Kinetics; Male; Middle Aged; Probenecid; Sodium Chloride Symporter Inhibitors; Ticrynafen; Uric Acid | 1979 |
[Uric acid lowering effects of benzbromarone (Harolan) by increasing uric acid excretion].
Topics: Adult; Aged; Allopurinol; Benzbromarone; Benzofurans; Female; Humans; Male; Middle Aged; Uric Acid | 1979 |
[Effect of uric acid lowering drugs in low dosage in patients with hyperuricemia and hypertriglyceridemia in a randomized group study].
Topics: Adult; Allopurinol; Benzbromarone; Benzofurans; Drug Combinations; Humans; Hyperlipidemias; Male; Middle Aged; Triglycerides; Uric Acid | 1979 |
[Letter: Use of urate oxidase and allopurinol as hypouricemic agents in hematology].
Topics: Allopurinol; Clinical Trials as Topic; Drug Synergism; Drug Therapy, Combination; Hematologic Diseases; Humans; Urate Oxidase; Uric Acid | 1976 |
[Letter; Treatment of urinary calcic lithiasis with allopurinol].
Topics: Allopurinol; Calcium; Clinical Trials as Topic; Female; Humans; Kidney Calculi; Male; Uric Acid | 1976 |
[Reducing the risks in the treatment of gout and hyperuricaemia (author's transl)].
Topics: Adult; Allopurinol; Benzbromarone; Benzofurans; Clinical Trials as Topic; Drug Combinations; Female; Gout; Humans; Male; Metabolic Clearance Rate; Middle Aged; Uric Acid | 1976 |
[Dosage of allopurinol. A comparative cross-over study of daily single and multiple doses].
Topics: Adult; Allopurinol; Female; Humans; Male; Middle Aged; Tablets; Tablets, Enteric-Coated; Uric Acid | 1977 |
[Therapy with alllopurinol and benzbromarone, single and combined. Renal elimination of lithogenous and colloid protective substances (author's transl)].
Topics: Adult; Aged; Allopurinol; Benzbromarone; Benzofurans; Calcium; Citrates; Creatinine; Glomerular Filtration Rate; Gout; Humans; Magnesium; Male; Middle Aged; Natriuresis; Sodium; Uric Acid | 1977 |
Single daily dose of allopurinol.
Topics: Administration, Oral; Adult; Aged; Allopurinol; Clinical Trials as Topic; Gout; Humans; Middle Aged; Tablets; Time Factors; Uric Acid | 1975 |
Clinical experiences with Milurit treatment in uricacidemia of various origin.
Topics: Adult; Aged; Allopurinol; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Uric Acid; Uricosuric Agents | 1975 |
Allopurinol and gouty hyperuricemia. Efficacy of a single daily dose.
Topics: Acute Disease; Adult; Aged; Allopurinol; Analysis of Variance; Chemical Phenomena; Chemistry; Gout; Humans; Informed Consent; Male; Methods; Middle Aged; Pyrazoles; Pyrimidines; Spectrophotometry; Tablets; Time Factors; Uric Acid | 1975 |
The relationship between glucose and uric acid metabolism: influence of short term allopurinol on glucose metabolism.
Topics: Adult; Aged; Allopurinol; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Double-Blind Method; Glycated Hemoglobin; Humans; Middle Aged; Uric Acid | 1991 |
[Effectiveness and tolerance of long-term uricosuric treatment].
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Drug Combinations; Female; Gout; Humans; Kidney Calculi; Male; Middle Aged; Uric Acid | 1990 |
Allopurinol and thiazide effects on new urinary stone formed after discontinued therapy in patients with urinary stones.
Topics: Allopurinol; Calcium; Calcium Oxalate; Calcium Phosphates; Citrates; Drug Therapy, Combination; Humans; Incidence; Male; Oxalates; Recurrence; Trichlormethiazide; Uric Acid; Urinary Calculi | 1990 |
A study of dose-response relationships of allopurinol in the presence of low or high purine turnover.
Topics: Adult; Allopurinol; Dose-Response Relationship, Drug; Female; Humans; Male; Purines; RNA; Uric Acid | 1988 |
Intermittent control of hyperuricemia in the treatment of gout.
Topics: Allopurinol; Drug Administration Schedule; Gout; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Time Factors; Uric Acid | 1989 |
[The effect of allopurinol therapy on kidney processes concomitant with gout].
Topics: Allopurinol; Clinical Trials as Topic; Drug Evaluation; Gout; Humans; Kidney Diseases; Kidney Tubules; Male; Uric Acid | 1987 |
Comparative trial of azapropazone and indomethacin plus allopurinol in acute gout and hyperuricaemia.
Topics: Adult; Aged; Allopurinol; Apazone; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Female; Gout; Humans; Indomethacin; Male; Middle Aged; Random Allocation; Triazines; Uric Acid | 1987 |
Randomized trial of allopurinol in the prevention of calcium oxalate calculi.
Topics: Allopurinol; Calcium Oxalate; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Kidney Calculi; Male; Middle Aged; Random Allocation; Recurrence; Uric Acid | 1986 |
Antihyperuricemic properties of amflutizole in gout.
Topics: Adult; Aged; Arthritis; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Tolerance; Female; Gout; Gout Suppressants; Humans; Kidney; Male; Middle Aged; Random Allocation; Thiazoles; Uric Acid; Xanthine Oxidase | 1985 |
Allopurinol in psoriasis--a double-blind study.
Topics: Adult; Allopurinol; Clinical Trials as Topic; Dermatitis, Exfoliative; Drug Eruptions; Female; Hospitalization; Humans; Male; Middle Aged; Nails; Placebos; Psoriasis; Uric Acid | 1973 |
[Benziodarone in hyperuricemia due to renal insufficiency].
Topics: Acute Kidney Injury; Adult; Aged; Allopurinol; Benzofurans; Clinical Trials as Topic; Gout; Humans; Kidney Diseases; Kidney Failure, Chronic; Metabolic Clearance Rate; Middle Aged; Urea; Uric Acid | 1973 |
Observations on the disposition of probenecid in patients receiving allopurinol.
Topics: Adult; Aged; Allopurinol; Animals; Blood Urea Nitrogen; Carbon Isotopes; Chromatography, Gas; Clinical Trials as Topic; Creatinine; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Liver; Male; Middle Aged; Probenecid; Proteins; Rats; Time Factors; Uric Acid; Xanthines | 1972 |
A crossover study of allopurinol administration to a schizophrenic child.
Topics: Administration, Oral; Allopurinol; Child; Child Behavior Disorders; Clinical Trials as Topic; Diet Therapy; Dose-Response Relationship, Drug; Echolalia; Humans; Male; Placebos; Purines; Remission, Spontaneous; Schizophrenia; Schizophrenia, Childhood; Self Concept; Uric Acid; Xanthine Oxidase | 1974 |
Effect of long-term allopurinol administration on serial GFR in normotensive and hypertensive hyperuricemic subjects.
Topics: Adult; Allopurinol; Blood Pressure; Creatinine; Female; Follow-Up Studies; Glomerular Filtration Rate; Gout; Humans; Hypertension; Male; Mathematics; Middle Aged; Placebos; Uric Acid | 1974 |
Effect of allopurinol on urinary ammonia excretion in patients with gout.
Topics: Aged; Allopurinol; Ammonia; Ammonium Chloride; Clinical Trials as Topic; Computers; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1969 |
Renal function in gout. 3. Estimation of tubular secretion and reabsorption of uric acid by use of pyrazinamide (pyrazinoic acid).
Topics: Adult; Allopurinol; Clinical Trials as Topic; Gout; Humans; Kidney Tubules; Metabolic Clearance Rate; Middle Aged; Pyrazinamide; RNA; Uric Acid | 1969 |
Prevention of hyperuricemia by allopurinol in hypertensive patients treated with chlorothiazide.
Topics: Allopurinol; Blood Pressure; Blood Urea Nitrogen; Chlorothiazide; Clinical Trials as Topic; Creatinine; Female; Humans; Hypertension; Male; Placebos; Potassium; Pulse; Sodium; Uric Acid | 1970 |
Allopurinol in psoriasis.
Topics: Adult; Aged; Allopurinol; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Psoriasis; Purines; Uric Acid; Xanthine Oxidase | 1970 |
Clinical efficacy and lack of toxicity of allopurinol (NSC-1390) given intravenously.
Topics: Administration, Oral; Adolescent; Adult; Alkaline Phosphatase; Allopurinol; Blood Urea Nitrogen; Child; Child, Preschool; Clinical Trials as Topic; Female; Gout; Humans; Injections, Intravenous; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Male; Middle Aged; Uric Acid | 1970 |
Uricosurics and xanthine oxidase inhibitors: a single-dose assay.
Topics: Adult; Allopurinol; Chlorothiazide; Humans; Male; Methods; Placebos; Probenecid; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1970 |
Comparison of allopurinol and probenecid.
Topics: Allopurinol; Clinical Trials as Topic; Colchicine; Enzyme Therapy; Follow-Up Studies; Gout; Humans; Liver Function Tests; Male; Probenecid; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Treatment of gout with allopurinol. A study of 106 cases.
Topics: Allopurinol; Clinical Trials as Topic; Colchicine; Diuresis; Enzymes; Gout; Humans; Purines; Uric Acid; Xanthine Oxidase | 1966 |
Treatment of gout with allopurinol and sulphinpyrazone in combination and with allopurinol alone.
Topics: Acute Kidney Injury; Adult; Aged; Allopurinol; Arthritis, Rheumatoid; Clinical Trials as Topic; Duodenal Ulcer; Enzyme Therapy; Female; Gout; Humans; Male; Middle Aged; Psoriasis; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Effect of drugs on urate binding to plasma proteins.
Topics: Adult; Allopurinol; Arthritis; Aspirin; Blood Proteins; Chromatography, DEAE-Cellulose; Colchicine; Female; Gout; Humans; Indomethacin; Male; Phenylbutazone; Probenecid; Protein Binding; Sulfinpyrazone; Uric Acid | 1969 |
Allopurinol in treatment of gout.
Topics: Adult; Aged; Enzyme Therapy; Enzymes; Female; Gout; Humans; Liver Function Tests; Male; Middle Aged; Proteinuria; Radiography; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1966 |
[Allopurinol in the treatment of gout and uric acid nephrolithiasis].
Topics: Allopurinol; Enzyme Therapy; Gout; Humans; Kidney Calculi; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1967 |
Placebo versus allopurinol for recurrent urinary calculi.
Topics: Allopurinol; Clinical Trials as Topic; Humans; Hydrogen-Ion Concentration; Uric Acid; Urinary Calculi | 1983 |
Role of hyperuricaemia in critically ill patients especially newborns.
Topics: Acute Disease; Age Factors; Allopurinol; Animals; Child; Clinical Trials as Topic; Humans; Infant; Infant, Newborn; Kidney; Metabolic Diseases; Rats; Respiratory Distress Syndrome, Newborn; Uric Acid | 1984 |
Medical management of nephrolithiasis.
Topics: Allopurinol; Ambulatory Care; Benzothiadiazines; Calcium; Calcium Oxalate; Calcium, Dietary; Cation Exchange Resins; Cellulose; Citrates; Citric Acid; Clinical Trials as Topic; Diuretics; Fluid Therapy; Humans; Kidney Calculi; Phosphates; Recurrence; Sodium Chloride Symporter Inhibitors; Uric Acid | 1982 |
A controlled study of the effect of long term allopurinol treatment on renal function in gout.
Topics: Allopurinol; Clinical Trials as Topic; Colchicine; Female; Follow-Up Studies; Gout; Humans; Kidney; Kidney Calculi; Male; Middle Aged; Uric Acid | 1980 |
[Mechanism of the action of allopurinol].
Topics: Adult; Aged; Allopurinol; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Gout; Humans; Middle Aged; Time Factors; Uric Acid | 1981 |
Benzbromarone therapy in hyperuricaemia; comparison with allopurinol and probenecid.
Topics: Adult; Allopurinol; Benzbromarone; Benzofurans; Clinical Trials as Topic; Female; Humans; Male; Placebos; Probenecid; Uric Acid | 1981 |
Evaluation of bone marrow toxic reaction in patients treated with allopurinol.
Topics: Allopurinol; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Clinical Trials as Topic; Depression, Chemical; Drug Therapy, Combination; Humans; Lymphoma; Random Allocation; Uric Acid | 1982 |
[The effect on uric acid and other laboratory parameters. A long-term study].
Topics: Allopurinol; Benzbromarone; Benzofurans; Clinical Trials as Topic; Gout; Humans; Uric Acid | 1982 |
[Therapeutic trial with allopurinol in progressive muscular dystrophy (author's transl)].
Topics: Adolescent; Allopurinol; Child; Child, Preschool; Clinical Trials as Topic; Creatine Kinase; Double-Blind Method; Exercise Test; Humans; Male; Muscle Contraction; Muscular Dystrophies; Uric Acid | 1982 |
[Treatment of hyperuricemia during cytostatic therapy].
Topics: Adenocarcinoma; Adult; Aged; Allopurinol; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Lymphoma; Middle Aged; Multiple Myeloma; Sarcoma; Uric Acid | 1982 |
Azapropazone or allopurinol in the treatment of chronic gout and/or hyperuricaemia. A preliminary report.
Topics: Adult; Aged; Allopurinol; Apazone; Female; Gout; Humans; Kidney Function Tests; Male; Middle Aged; Triazines; Uric Acid | 1982 |
[Therapeutic efficacy of slow-release allopurinol in gout and hyperuricaemia (author's transl)].
Topics: Allopurinol; Delayed-Action Preparations; Dose-Response Relationship, Drug; Gout; Humans; Uric Acid | 1981 |
The influence of allopurinol on renal deterioration in familial nepropathy associated with hyperuricemia (FNAH). The Spanish Group for the Study of FNAH.
Topics: Adolescent; Adult; Aged; Allopurinol; Creatinine; Female; Follow-Up Studies; Humans; Hypertension; Kidney Diseases; Male; Pedigree; Prospective Studies; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid | 1994 |
Improvement of cardiac function by allopurinol in patients undergoing cardiac surgery.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Blood Pressure; Cardiac Output; Coronary Artery Bypass; Coronary Disease; Creatine Kinase; Female; Free Radicals; Heart; Humans; Injections, Intravenous; Lactates; Lactic Acid; Male; Middle Aged; Oxidative Stress; Stroke Volume; Sulfhydryl Compounds; Uric Acid; Xanthine Oxidase | 1995 |
Pharmacokinetic and pharmacodynamic properties of a novel xanthine oxidase inhibitor, BOF-4272, in healthy volunteers.
Topics: Adult; Half-Life; Humans; Male; Reference Values; Triazines; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1994 |
[Effects of allopurinol on uric acid metabolism and lipid peroxidation in ischemic heart disease patients with stable angina].
Topics: Adult; Allopurinol; Angina Pectoris; Drug Therapy, Combination; Hemodynamics; Humans; Lipid Peroxidation; Male; Middle Aged; Pentaerythritol Tetranitrate; Uric Acid | 1993 |
Uricosuric effect of CGS-12970, a new thromboxane synthase inhibitor.
Topics: Adolescent; Adult; Animals; Cattle; Creatinine; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Middle Aged; Pyridines; Reference Values; Single-Blind Method; Thromboxane-A Synthase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1993 |
The effect of benzbromarone on allopurinol/oxypurinol kinetics in patients with gout.
Topics: Adult; Aged; Allopurinol; Benzbromarone; Gout; Humans; Male; Middle Aged; Oxypurinol; Uric Acid | 1993 |
Tourniquet-induced exsanguination in patients requiring lower limb surgery. An ischemia-reperfusion model of oxidant and antioxidant metabolism.
Topics: Adult; Antioxidants; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; Ischemia; Knee Joint; Leg; Oxidants; Reperfusion; Superoxides; Tourniquets; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1996 |
Disposition and uric acid lowering effect of oxipurinol: comparison of different oxipurinol formulations and allopurinol in healthy individuals.
Topics: Administration, Oral; Adult; Allopurinol; Chemistry, Pharmaceutical; Cross-Over Studies; Enzyme Inhibitors; Gout Suppressants; Humans; Male; Oxypurinol; Uric Acid | 1995 |
A phase II trail of aminothiadiazole in patients with mixed mesodermal tumors of the uterine corpus: a Gynecologic Oncology Group study.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Antineoplastic Agents; Drug Administration Schedule; Female; Gout Suppressants; Humans; Infusions, Intravenous; Middle Aged; Mixed Tumor, Mesodermal; Remission Induction; Thiadiazoles; Uric Acid; Uterine Neoplasms | 1996 |
Uric acid lowering effect of oxipurinol sodium in hyperuricemic patients - therapeutic equivalence to allopurinol.
Topics: Adult; Aged; Allopurinol; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Hematocrit; Humans; Leukocyte Count; Male; Middle Aged; Oxypurinol; Therapeutic Equivalency; Uric Acid | 1996 |
Antioxidants in the treatment of severe pre-eclampsia: an explanatory randomised controlled trial.
Topics: Adolescent; Adult; Allopurinol; Antioxidants; Ascorbic Acid; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Lipid Peroxides; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Uric Acid; Vitamin E | 1997 |
Urate oxidase in prevention and treatment of hyperuricemia associated with lymphoid malignancies.
Topics: Allopurinol; Antimetabolites; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Time Factors; Urate Oxidase; Uric Acid | 1997 |
Effect of allopurinol and benzbromarone on the concentration of uridine in plasma.
Topics: Adult; Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Gout; Gout Suppressants; Humans; Male; Middle Aged; Purines; Pyrimidines; Time Factors; Uric Acid; Uricosuric Agents; Uridine; Xanthine Oxidase | 1997 |
Does allopurinol reduce pain of chronic pancreatitis?
Topics: Abdominal Pain; Activities of Daily Living; Adult; Allopurinol; Ankle; Blood Cell Count; Chronic Disease; Cross-Over Studies; Diarrhea; Double-Blind Method; Enzyme Inhibitors; Exanthema; Face; Female; Humans; Joints; Liver Function Tests; Male; Middle Aged; Nausea; Pain; Pain Measurement; Pancreatitis; Placebos; Prospective Studies; Uric Acid; Vomiting | 1997 |
Evaluating the efficacy of allopurinol for the treatment of cutaneous leishmaniasis.
Topics: Adolescent; Adult; Allopurinol; Antimetabolites, Antineoplastic; Brazil; Child; Evaluation Studies as Topic; Follow-Up Studies; Humans; Leishmaniasis, Cutaneous; Meglumine; Middle Aged; Mucous Membrane; Treatment Outcome; Ulcer; Uric Acid | 1997 |
Determination of uric acid in scalp hair for non-invasive evaluation of uricemic controls in hyperuricemia.
Topics: Adult; Allopurinol; Gout; Gout Suppressants; Hair; Humans; Hydroxides; Middle Aged; Potassium Compounds; Uric Acid | 1998 |
Efficacy of allopurinol and benzbromarone for the control of hyperuricaemia. A pathogenic approach to the treatment of primary chronic gout.
Topics: Adult; Aged; Allopurinol; Benzbromarone; Chronic Disease; Drug Administration Schedule; Gout; Gout Suppressants; Humans; Male; Middle Aged; Prospective Studies; Uric Acid; Uricosuric Agents | 1998 |
Allopurinol does not increase free radical scavenging capacity during reperfusion in coronary artery bypass graft patients.
Topics: Aged; Allopurinol; Analysis of Variance; Coronary Artery Bypass; Coronary Disease; Double-Blind Method; Free Radical Scavengers; Free Radicals; Humans; Hypoxanthine; Infusions, Intravenous; Intraoperative Period; Male; Middle Aged; Preoperative Care; Probability; Reference Values; Reperfusion; Sensitivity and Specificity; Uric Acid; Xanthine | 2000 |
Improvement of renal function in patients with chronic gout after proper control of hyperuricemia and gouty bouts.
Topics: Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Creatinine; Drug Therapy, Combination; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Male; Middle Aged; Prospective Studies; Renal Insufficiency; Risk Factors; Uric Acid; Uricosuric Agents | 2000 |
Effect of furosemide on renal excretion of oxypurinol and purine bases.
Topics: Administration, Oral; Adult; Aldosterone; Allopurinol; Angiotensin II; Chlorides; Creatinine; Diuretics; Drug Therapy, Combination; Furosemide; Humans; Injections, Intravenous; Kidney; Male; Metabolic Clearance Rate; Middle Aged; Oxypurinol; Potassium; Purines; Sodium; Uric Acid; Xanthine Oxidase | 2001 |
Treatment of chronic gout. Can we determine when urate stores are depleted enough to prevent attacks of gout?
Topics: Allopurinol; Chronic Disease; Colchicine; Crystallization; Extracellular Space; Follow-Up Studies; Gout; Gout Suppressants; Humans; Knee Joint; Male; Prospective Studies; Treatment Outcome; Uric Acid | 2001 |
A placebo-controlled study examining the effect of allopurinol on heart rate variability and dysrhythmia counts in chronic heart failure.
Topics: Aged; Allopurinol; Arrhythmias, Cardiac; Cardiac Output, Low; Cross-Over Studies; Data Interpretation, Statistical; Double-Blind Method; Female; Free Radical Scavengers; Heart Rate; Humans; Male; Placebos; Uric Acid | 2001 |
A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis.
Topics: Adolescent; Allopurinol; Child; Child, Preschool; Creatinine; Drugs, Investigational; Female; Humans; Infant; Kidney; Kinetics; Leukemia; Lymphoma; Male; Recombinant Proteins; Renal Insufficiency; Risk Factors; Treatment Outcome; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2001 |
Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest.
Topics: Allopurinol; Cardiac Surgical Procedures; Coma; Death, Sudden, Cardiac; Female; Free Radical Scavengers; Heart Arrest, Induced; Heart Defects, Congenital; Humans; Hypothermia, Induced; Infant; Male; Neuroprotective Agents; Oxygen; Seizures; Single-Blind Method; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2001 |
Diet and medication in the treatment of hyperuricemia in hypertensive patients.
Topics: Allopurinol; Benzothiadiazines; Cardiovascular Diseases; Diet; Diuretics; Energy Intake; Ethanol; Exercise; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Risk Factors; Smoking; Sodium Chloride Symporter Inhibitors; Treatment Outcome; Uric Acid | 2001 |
Effect of fenofibrate on plasma concentration and urinary excretion of purine bases and oxypurinol.
Topics: Adult; Allopurinol; Cholesterol; Creatinine; Drug Interactions; Fenofibrate; Gout Suppressants; Humans; Hypolipidemic Agents; Hypoxanthine; Male; Oxypurinol; Purines; Triglycerides; Uric Acid; Xanthine | 2001 |
Safety of the allopurinol-mycophenolate mofetil combination in the treatment of hyperuricemia of kidney transplant recipients.
Topics: Adult; Allopurinol; Cyclosporine; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Mycophenolic Acid; Risk Factors; Uric Acid | 2002 |
Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies.
Topics: Administration, Oral; Aged; Allantoin; Allopurinol; Blood Flow Velocity; Chronic Disease; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Forearm; Heart Failure; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Oxidative Stress; Regional Blood Flow; Uric Acid; Vasodilation; Xanthine Oxidase | 2002 |
Effects of angiotensin II infusion on renal excretion of purine bases and oxypurinol.
Topics: Administration, Oral; Adult; Allopurinol; Angiotensin II; Blood Pressure; Creatinine; Humans; Hypoxanthine; Infusions, Intravenous; Kidney; Male; Middle Aged; Oxypurinol; Purines; Reference Values; Sodium; Uric Acid; Xanthine | 2002 |
Efficacy of benzbromarone compared to allopurinol in lowering serum uric acid level in hyperuricemic patients.
Topics: Adult; Aged; Allopurinol; Benzbromarone; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Gout; Humans; Male; Middle Aged; Probability; Statistics, Nonparametric; Treatment Outcome; Uric Acid; Uricosuric Agents; Urinalysis | 2002 |
Effect of urate-lowering therapy on the velocity of size reduction of tophi in chronic gout.
Topics: Adult; Aged; Allopurinol; Benzbromarone; Crystallization; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Prospective Studies; Uric Acid | 2002 |
[Clinical study of treatment on chronic uric acid nephropathy by integrating Western and traditional Chinese medicine].
Topics: Adult; Aged; Allopurinol; Blood Viscosity; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Kidney Diseases; Male; Medicine, Chinese Traditional; Middle Aged; Phytotherapy; Uric Acid | 2002 |
Further studies on the use of allopurinol to reduce plasma uric acid concentrations in the Red-tailed Hawk (Buteo jamaicensis) hyperuricaemic model.
Topics: Allopurinol; Animals; Bird Diseases; Female; Gout Suppressants; Hyperuricemia; Male; Postprandial Period; Raptors; Uric Acid | 2002 |
Fenofibrate enhances urate reduction in men treated with allopurinol for hyperuricaemia and gout.
Topics: Acute Disease; Adult; Aged; Alkaline Phosphatase; Allopurinol; Arthritis, Gouty; Chronic Disease; Cross-Over Studies; Drug Therapy, Combination; Fenofibrate; Gout; Gout Suppressants; Humans; Hyperuricemia; Hypolipidemic Agents; Lipids; Male; Middle Aged; Recurrence; Uric Acid | 2003 |
Oxidized low-density lipoprotein autoantibodies in patients with primary gout: effect of urate-lowering therapy.
Topics: Allopurinol; Antioxidants; Autoantibodies; Body Weight; Case-Control Studies; Cholesterol, HDL; Cholesterol, LDL; Gout; Humans; Lipoproteins, LDL; Male; Middle Aged; Smoking; Triglycerides; Uric Acid | 2004 |
Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Enzyme Inhibitors; Febuxostat; Female; Humans; Liver; Male; Placebos; Purines; Thiazoles; Time Factors; Uric Acid; Xanthine Oxidase | 2004 |
Pharmacokinetics/pharmacodynamics of Y-700, a novel xanthine oxidase inhibitor, in rats and man.
Topics: Administration, Oral; Adult; Animals; Area Under Curve; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hyperuricemia; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Time Factors; Uric Acid; Xanthine Oxidase | 2004 |
Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Febuxostat; Female; Gout; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2005 |
Benzbromarone therapy in management of refractory gout.
Topics: Adult; Allopurinol; Benzbromarone; Creatinine; Female; Gout; Humans; Incidence; Male; Metabolic Clearance Rate; Middle Aged; New Zealand; Treatment Outcome; Uric Acid | 2005 |
The influence of allopurinol on urinary purine loss after repeated sprint exercise in man.
Topics: Adult; Allopurinol; Exercise; Humans; Inosine; Kidney; Male; Purines; Uric Acid | 2005 |
Febuxostat compared with allopurinol in patients with hyperuricemia and gout.
Topics: Allopurinol; Double-Blind Method; Enzyme Inhibitors; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Uric Acid; Xanthine Oxidase | 2005 |
Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level.
Topics: Adult; Aged; Allopurinol; Creatinine; Disease Progression; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Hypertension; Hyperuricemia; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Proteinuria; Renal Dialysis; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2006 |
Pharmacokinetics, pharmacodynamics and safety of febuxostat, a non-purine selective inhibitor of xanthine oxidase, in a dose escalation study in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Dose-Response Relationship, Drug; Enzyme Inhibitors; Febuxostat; Female; Gout Suppressants; Humans; Hypoxanthine; Male; Models, Biological; Thiazoles; Uric Acid; Xanthine; Xanthine Oxidase | 2006 |
The effect of xanthine oxidase inhibition upon ejection fraction in heart failure patients: La Plata Study.
Topics: Aged; Double-Blind Method; Enzyme Inhibitors; Female; Heart Failure; Humans; Male; Oxypurinol; Physical Endurance; Stroke Volume; Uric Acid; Walking; Xanthine Oxidase | 2006 |
High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid.
Topics: Acetylcholine; Aged; Allopurinol; Ascorbic Acid; Blood Pressure; Cardiac Output, Low; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nitroprusside; Oxidative Stress; Probenecid; Regional Blood Flow; Uric Acid; Uricosuric Agents; Vasodilator Agents | 2006 |
Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-treated gout patients.
Topics: Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Humans; Hyperuricemia; Male; Middle Aged; Probenecid; Uric Acid; Uricosuric Agents | 2007 |
Prevention and treatment of hyperuricemia with rasburicase in children with leukemia and non-Hodgkin's lymphoma.
Topics: Adolescent; Allopurinol; Child; Child, Preschool; Female; Humans; Hyperuricemia; Infant; Leukemia; Lymphoma, Non-Hodgkin; Male; Recombinant Proteins; Urate Oxidase; Uric Acid | 2007 |
Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects.
Topics: Adult; Allopurinol; Analysis of Variance; Area Under Curve; Chromatography, High Pressure Liquid; Creatinine; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Oxypurinol; Probenecid; Time Factors; Uric Acid | 2008 |
Efficacy and tolerability of urate-lowering drugs in gout: a randomised controlled trial of benzbromarone versus probenecid after failure of allopurinol.
Topics: Aged; Allopurinol; Benzbromarone; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Hypersensitivity; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Probenecid; Prospective Studies; Treatment Failure; Uric Acid | 2009 |
Consumption of green tea favorably affects oxidative stress markers in weight-trained men.
Topics: Adult; Antioxidants; Aspartate Aminotransferases; Beverages; Biomarkers; Creatine Kinase; Cross-Over Studies; Exercise; Flavonoids; Glutathione; Humans; Hypoxanthine; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption; Phenols; Polyphenols; Tea; Thiobarbituric Acid Reactive Substances; Uric Acid; Weight Lifting; Xanthine Oxidase | 2008 |
Higher therapeutic plasma oxypurinol concentrations might be required for gouty patients with chronic kidney disease.
Topics: Adult; Aged; Allopurinol; Dose-Response Relationship, Drug; Drug Monitoring; Female; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Uric Acid | 2008 |
Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Enzyme Inhibitors; Female; Health Status Indicators; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Oxypurinol; Quality of Life; Surveys and Questionnaires; Systole; Uric Acid; Xanthine Oxidase | 2008 |
A randomised controlled trial on the efficacy and tolerability with dose escalation of allopurinol 300-600 mg/day versus benzbromarone 100-200 mg/day in patients with gout.
Topics: Aged; Allopurinol; Benzbromarone; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Oxypurinol; Patient Compliance; Prospective Studies; Treatment Outcome; Uric Acid; Uricosuric Agents | 2009 |
The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Biotransformation; Enzyme Inhibitors; Febuxostat; Female; Gout Suppressants; Humans; Hypoxanthine; Male; Protein Binding; Sex Factors; Thiazoles; Uric Acid; Xanthine; Xanthine Oxidase; Young Adult | 2008 |
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Topics: Adolescent; Allopurinol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hypertension; Hyperuricemia; Male; Uric Acid; Xanthine Oxidase | 2008 |
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Brain Ischemia; C-Reactive Protein; Double-Blind Method; Female; Humans; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 2008 |
Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial.
Topics: Adult; Aged; Allopurinol; Creatinine; Dose-Response Relationship, Drug; Double-Blind Method; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid | 2008 |
Allopurinol treatment reduces arterial wave reflection in stroke survivors.
Topics: Aged; Allopurinol; Antioxidants; Arteries; Blood Pressure; Double-Blind Method; Elasticity; Enzyme Inhibitors; Female; Humans; Male; Stroke; Survivors; Uric Acid; Xanthine Oxidase | 2008 |
[Observation on therapeutic effect of surrounded needling therapy on acute gouty arthritis].
Topics: Acupuncture Points; Acupuncture Therapy; Acute Disease; Adult; Aged; Allopurinol; Arthritis, Gouty; Humans; Indomethacin; Male; Middle Aged; Treatment Outcome; Uric Acid | 2009 |
The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial.
Topics: Aged; Allopurinol; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Double-Blind Method; Enzyme Inhibitors; Humans; Middle Aged; Statistics as Topic; Stroke; Uric Acid; Vasodilation; Xanthine Oxidase | 2009 |
Uric acid-lowering treatment with benzbromarone in patients with heart failure: a double-blind placebo-controlled crossover preliminary study.
Topics: Aged; Benzbromarone; Double-Blind Method; Female; Heart Failure; Humans; Hyperuricemia; Male; Middle Aged; Treatment Outcome; Up-Regulation; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2010 |
Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response.
Topics: Adult; Aged; Allopurinol; Antimetabolites; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Fasting; Fructose; Humans; Hypertension; Insulin; Lipids; Male; Metabolic Syndrome; Middle Aged; Pilot Projects; Triglycerides; Uric Acid | 2010 |
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Dose-Response Relationship, Drug; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperlipidemias; Hypertension; Hyperuricemia; Kidney Diseases; Male; Middle Aged; Obesity; Thiazoles; Treatment Outcome; United States; Uric Acid; Young Adult | 2010 |
Effect of allopurinol in chronic kidney disease progression and cardiovascular risk.
Topics: Aged; Allopurinol; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chi-Square Distribution; Chronic Disease; Disease Progression; Glomerular Filtration Rate; Gout Suppressants; Hospitalization; Humans; Hyperuricemia; Inflammation Mediators; Kaplan-Meier Estimate; Kidney Diseases; Middle Aged; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Spain; Time Factors; Treatment Outcome; Uric Acid | 2010 |
Effect of hydrochlorothiazide on the pharmacokinetics and pharmacodynamics of febuxostat, a non-purine selective inhibitor of xanthine oxidase.
Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Febuxostat; Female; Gout Suppressants; Humans; Hydrochlorothiazide; Male; Middle Aged; Thiazoles; Uric Acid; Xanthine Oxidase; Young Adult | 2010 |
More allopurinol is needed to get gout patients < 0.36 mmol/l: a gout audit in the form of a before-after trial.
Topics: Aged; Allopurinol; Benchmarking; Clinical Audit; Cultural Competency; Diagnosis, Differential; Gout; Gout Suppressants; Humans; Medication Adherence; Middle Aged; Native Hawaiian or Other Pacific Islander; New Zealand; Pilot Projects; Uric Acid; White People | 2009 |
Control of plasma uric acid in adults at risk for tumor Lysis syndrome: efficacy and safety of rasburicase alone and rasburicase followed by allopurinol compared with allopurinol alone--results of a multicenter phase III study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Antineoplastic Agents; Biomarkers; Drug Therapy, Combination; Female; Hematologic Neoplasms; Humans; Hyperuricemia; Infusions, Intravenous; Male; Middle Aged; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Tumor Lysis Syndrome; United States; Urate Oxidase; Uric Acid; Young Adult | 2010 |
Elevated levels of asymmetric dimethylarginine in chronic heart failure: a pathophysiologic link between oxygen radical load and impaired vasodilator capacity and the therapeutic effect of allopurinol.
Topics: Aged; Allopurinol; Arginine; Chronic Disease; Citrulline; Cross-Sectional Studies; Double-Blind Method; Female; Free Radical Scavengers; Heart Failure; Humans; Male; Middle Aged; Reactive Oxygen Species; Uric Acid; Vasodilation | 2010 |
The alkalizer citrate reduces serum uric Acid levels and improves renal function in hyperuricemic patients treated with the xanthine oxidase inhibitor allopurinol.
Topics: Allopurinol; Citric Acid; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Prospective Studies; Uric Acid; Xanthine Oxidase | 2010 |
Uric acid level and allopurinol use as risk markers of mortality and morbidity in systolic heart failure.
Topics: Aged; Allopurinol; Biomarkers; Enzyme Inhibitors; Female; Follow-Up Studies; Heart Failure, Systolic; Humans; Hyperuricemia; Male; Middle Aged; Morbidity; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Survival Rate; United States; Uric Acid | 2010 |
Effect of long-term and high-dose allopurinol therapy on endothelial function in normotensive diabetic patients.
Topics: Allopurinol; Blood Flow Velocity; Blood Pressure; Brachial Artery; Diabetes Mellitus; Drug Administration Schedule; Endothelium, Vascular; Enzyme Inhibitors; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Nitrates; Oxidative Stress; Turkey; Uric Acid; Vasodilation; Xanthine Oxidase | 2011 |
Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairment.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Creatinine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Kidney Diseases; Male; Middle Aged; Treatment Outcome; Uric Acid | 2011 |
Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in patients with gout.
Topics: Allopurinol; Drug Interactions; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Male; Middle Aged; Oxypurinol; Probenecid; Prospective Studies; Uric Acid; Uricosuric Agents | 2011 |
Effect of prophylaxis on gout flares after the initiation of urate-lowering therapy: analysis of data from three phase III trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Drug Administration Schedule; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid; Young Adult | 2010 |
Effect of allopurinol on blood pressure and aortic compliance in hypertensive patients.
Topics: Adult; Aged; Allopurinol; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aorta; Blood Pressure; Compliance; Diuretics; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Perindopril; Uric Acid; Uricosuric Agents | 2011 |
Febuxostat in gout: serum urate response in uric acid overproducers and underexcretors.
Topics: Adult; Aged; Double-Blind Method; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2011 |
An allopurinol-controlled, randomized, double-dummy, double-blind, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: p
Topics: Administration, Oral; Allopurinol; Dose-Response Relationship, Drug; Double-Blind Method; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2011 |
Placebo-controlled, double-blind study of the non-purine-selective xanthine oxidase inhibitor Febuxostat (TMX-67) in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study.
Topics: Adult; Central Nervous System Diseases; Dental Enamel; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Japan; Kidney Diseases, Cystic; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2011 |
A repeated oral administration study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with impaired renal function in Japan: pharmacokinetic and pharmacodynamic study.
Topics: Administration, Oral; Adult; Aged; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Febuxostat; Female; Follow-Up Studies; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Oxypurinol; Renal Insufficiency; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase; Young Adult | 2011 |
Placebo-controlled double-blind dose-response study of the non-purine-selective xanthine oxidase inhibitor febuxostat (TMX-67) in patients with hyperuricemia (including gout patients) in japan: late phase 2 clinical study.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Double-Blind Method; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2011 |
An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phas
Topics: Administration, Oral; Allopurinol; Dose-Response Relationship, Drug; Double-Blind Method; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Thiazoles; Time Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2011 |
Multicenter, open-label study of long-term administration of febuxostat (TMX-67) in Japanese patients with hyperuricemia including gout.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Thiazoles; Time Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2011 |
A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function.
Topics: Adult; Allopurinol; Analysis of Variance; Asymptomatic Diseases; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; C-Reactive Protein; Creatinine; Endothelium, Vascular; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Inflammation Mediators; Kidney; Male; Middle Aged; Prospective Studies; Proteinuria; Regression Analysis; Time Factors; Treatment Outcome; Turkey; Ultrasonography; Uric Acid; Vasodilation | 2011 |
Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials.
Topics: Allopurinol; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Enzymes, Immobilized; Female; Gout; Gout Suppressants; Humans; Infusions, Intravenous; Male; Middle Aged; Polyethylene Glycols; Treatment Outcome; Urate Oxidase; Uric Acid | 2011 |
Women with gout: efficacy and safety of urate-lowering with febuxostat and allopurinol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Comorbidity; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Illinois; Male; Metabolic Diseases; Middle Aged; Obesity; Retrospective Studies; Sex Factors; Thiazoles; Treatment Outcome; Uric Acid; Young Adult | 2012 |
Treating hyperuricemia of gout: safety and efficacy of febuxostat and allopurinol in older versus younger subjects.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Liver Function Tests; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid | 2011 |
The efficacy and safety of febuxostat for urate lowering in gout patients ≥65 years of age.
Topics: Aged; Aged, 80 and over; Biomarkers; Cohort Studies; Double-Blind Method; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2012 |
Furosemide increases plasma oxypurinol without lowering serum urate--a complex drug interaction: implications for clinical practice.
Topics: Adult; Aged; Allopurinol; Area Under Curve; Case-Control Studies; Diuretics; Drug Interactions; Drug Therapy, Combination; Female; Furosemide; Gout; Gout Suppressants; Humans; Male; Middle Aged; Oxypurinol; Treatment Outcome; Uric Acid; Urination | 2012 |
Rilonacept (interleukin-1 trap) for prevention of gout flares during initiation of uric acid-lowering therapy: results from a phase III randomized, double-blind, placebo-controlled, confirmatory efficacy study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Placebos; Recombinant Fusion Proteins; Treatment Outcome; Uric Acid | 2012 |
Patients with gout adhere to curative treatment if informed appropriately: proof-of-concept observational study.
Topics: Aged; Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Patient Compliance; Patient Education as Topic; Practice Patterns, Nurses'; Risk Reduction Behavior; Treatment Outcome; Uric Acid | 2013 |
Uric acid reduction rectifies prehypertension in obese adolescents.
Topics: Adolescent; Allopurinol; Blood Pressure; Child; Double-Blind Method; Drug Administration Schedule; Female; Humans; Male; Obesity; Prehypertension; Probenecid; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2012 |
The effects of allopurinol, uric acid, and inosine administration on xanthine oxidoreductase activity and uric acid concentrations in broilers.
Topics: Allopurinol; Animals; Chickens; Enzyme Inhibitors; Female; Inosine; Male; Uric Acid; Xanthine Oxidase | 2012 |
Preservation of renal function during gout treatment with febuxostat: a quantitative study.
Topics: Adult; Aged; Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Kidney; Kidney Function Tests; Male; Middle Aged; Thiazoles; Treatment Outcome; Uric Acid | 2013 |
Prednisone in Uric Acid lowering in Symptomatic Heart Failure Patients With Hyperuricemia (PUSH-PATH) study.
Topics: Adult; Allopurinol; Creatinine; Dyspnea; Female; Glomerular Filtration Rate; Glucocorticoids; Gout Suppressants; Heart Failure; Humans; Hyperuricemia; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Prednisone; Prospective Studies; Severity of Illness Index; Treatment Outcome; Uric Acid | 2013 |
Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial.
Topics: Adult; Allopurinol; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Medication Adherence; Middle Aged; Receptors, Interleukin-1 Type I; Recombinant Fusion Proteins; Treatment Outcome; Uric Acid | 2013 |
Effects of acute exercise and xanthine oxidase inhibition on novel cardiovascular biomarkers.
Topics: Administration, Oral; Adrenomedullin; Adult; Allopurinol; Athletes; Biomarkers; Double-Blind Method; Enzyme Inhibitors; Exercise; Glycopeptides; Growth Differentiation Factor 15; Humans; Male; Myocardium; Peptide Fragments; Placenta Growth Factor; Pregnancy Proteins; Protein Precursors; Soccer; Uric Acid; Vascular Endothelial Growth Factor Receptor-1; Xanthine Oxidase | 2013 |
Understanding the dose-response relationship of allopurinol: predicting the optimal dosage.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Creatinine; Dose-Response Relationship, Drug; Gout Suppressants; Humans; Linear Models; Middle Aged; Predictive Value of Tests; Prospective Studies; Retrospective Studies; Uric Acid; Young Adult | 2013 |
Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients (NU-FLASH Trial).
Topics: Aged; Albuminuria; Allopurinol; Arachidonic Acid; Blood Pressure; C-Reactive Protein; Cardiac Surgical Procedures; Cholesterol; Creatinine; Cystatin C; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Lipoproteins, LDL; Male; Middle Aged; Pulse Wave Analysis; Stroke Volume; Thiazoles; Uric Acid | 2013 |
Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout: a pilot randomized controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Ascorbic Acid; Creatinine; Dietary Supplements; Female; Gout; Humans; Male; Middle Aged; New Zealand; Pilot Projects; Treatment Outcome; Uric Acid | 2013 |
Randomized controlled trial of febuxostat versus allopurinol or placebo in individuals with higher urinary uric acid excretion and calcium stones.
Topics: Adult; Allopurinol; Biomarkers; Calcium Oxalate; Double-Blind Method; Enzyme Inhibitors; Febuxostat; Female; Humans; Male; Middle Aged; Multidetector Computed Tomography; Thiazoles; Time Factors; Treatment Outcome; United States; Uric Acid; Urinary Calculi; Xanthine Oxidase | 2013 |
Allopurinol reduces left ventricular mass in patients with type 2 diabetes and left ventricular hypertrophy.
Topics: Aged; Allopurinol; Analysis of Variance; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Heart Ventricles; Humans; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Multivariate Analysis; Uric Acid | 2013 |
As compared to allopurinol, urate-lowering therapy with febuxostat has superior effects on oxidative stress and pulse wave velocity in patients with severe chronic tophaceous gout.
Topics: Aged; Allopurinol; Biomarkers; Chronic Disease; Enzyme Inhibitors; Febuxostat; Germany; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Inflammation Mediators; Kidney; Male; Middle Aged; Oxidative Stress; Prospective Studies; Pulse Wave Analysis; Severity of Illness Index; Thiazoles; Time Factors; Treatment Outcome; Uric Acid; Vascular Stiffness; Xanthine Oxidase | 2014 |
Tophus burden reduction with pegloticase: results from phase 3 randomized trials and open-label extension in patients with chronic gout refractory to conventional therapy.
Topics: Adult; Aged; Allopurinol; Chronic Disease; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Polyethylene Glycols; Time Factors; Treatment Outcome; Urate Oxidase; Uric Acid | 2013 |
Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout.
Topics: Adiponectin; Aged; Albuminuria; Blood Pressure; Comorbidity; Creatinine; Double-Blind Method; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Gout; Humans; Hyperuricemia; Male; Middle Aged; Nitriles; Prevalence; Pyridines; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2014 |
An allopurinol-controlled, multicenter, randomized, double-blind, parallel between-group, comparative study of febuxostat in Chinese patients with gout and hyperuricemia.
Topics: Adult; Allopurinol; Biomarkers; China; Double-Blind Method; Enzyme Inhibitors; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Remission Induction; Thiazoles; Time Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2014 |
Allopurinol enhances the blood pressure lowering effect of enalapril in children with hyperuricemic essential hypertension.
Topics: Adolescent; Allopurinol; Antihypertensive Agents; Antimetabolites; Blood Pressure; Child; Drug Synergism; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Male; Prospective Studies; Uric Acid; Young Adult | 2014 |
Comparison of two plasma urate assays in patients receiving vitamin C supplementation.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Antimetabolites; Ascorbic Acid; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Dietary Supplements; Female; Humans; Male; Middle Aged; Uric Acid | 2014 |
Myeloperoxidase and oxidation of uric acid in gout: implications for the clinical consequences of hyperuricaemia.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Enzyme-Linked Immunosorbent Assay; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Mass Spectrometry; Middle Aged; Oxidation-Reduction; Oxidative Stress; Peroxidase; Uric Acid | 2014 |
The effects of allopurinol on metabolic acidosis and endothelial functions in chronic kidney disease patients.
Topics: Acidosis; Adult; Aged; Allopurinol; Bicarbonates; Creatinine; Endothelium; Female; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic; Uric Acid; Vasodilation | 2015 |
Inhibition of xanthine oxidase and exercise on serum uric acid, 25(OH)D3, and calcium concentrations.
Topics: Adult; Allopurinol; Athletes; Calcifediol; Calcium; Cellulose; Double-Blind Method; Enzyme Inhibitors; Exercise; Humans; Hyperuricemia; Male; Soccer; Treatment Outcome; Uric Acid; Vitamin D Deficiency; Xanthine Oxidase; Young Adult | 2014 |
Comprehensive dietary education in treated gout patients does not further improve serum urate.
Topics: Adult; Aged; Allopurinol; Australia; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Patient Compliance; Patient Education as Topic; Patient Satisfaction; Prognosis; Prospective Studies; Recurrence; Risk Assessment; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Uric Acid | 2015 |
Allopurinol and progression of CKD and cardiovascular events: long-term follow-up of a randomized clinical trial.
Topics: Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Creatinine; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; Gout Suppressants; Humans; Incidence; Longitudinal Studies; Male; Middle Aged; Renal Insufficiency, Chronic; Risk Factors; Treatment Outcome; Uric Acid | 2015 |
Comparison of febuxostat and allopurinol for hyperuricemia in cardiac surgery patients with chronic kidney disease (NU-FLASH trial for CKD).
Topics: Aged; Albuminuria; Allopurinol; C-Reactive Protein; Cardiac Surgical Procedures; Cholesterol; Creatinine; Cystatin C; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Renal Insufficiency, Chronic; Triglycerides; Uric Acid | 2015 |
Renoprotective effects of febuxostat in hyperuricemic patients with chronic kidney disease: a parallel-group, randomized, controlled trial.
Topics: Aged; Aged, 80 and over; Albuminuria; beta 2-Microglobulin; Enzyme Inhibitors; Fatty Acid-Binding Proteins; Febuxostat; Female; Humans; Hyperuricemia; Male; Middle Aged; Prospective Studies; Renal Insufficiency, Chronic; Uric Acid; Xanthine Oxidase | 2015 |
Does starting allopurinol prolong acute treated gout? A randomized clinical trial.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Allopurinol; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Time Factors; Treatment Outcome; Uric Acid | 2015 |
Comparison of pharmacokinetics and uric acid lowering effect between two different strength febuxostat formulations (80 mg vs. 40 mg) in healthy subjects.
Topics: Adult; Area Under Curve; Biomarkers; Cross-Over Studies; Down-Regulation; Enzyme Inhibitors; Febuxostat; Gout Suppressants; Half-Life; Healthy Volunteers; Humans; Linear Models; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Republic of Korea; Therapeutic Equivalency; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase; Young Adult | 2015 |
A phase 3, multicenter, randomized, allopurinol-controlled study assessing the safety and efficacy of oral febuxostat in Chinese gout patients with hyperuricemia.
Topics: Administration, Oral; Adult; Allopurinol; Biomarkers; China; Double-Blind Method; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Time Factors; Treatment Outcome; Uric Acid | 2015 |
An open-label, 6-month study of allopurinol safety in gout: The LASSO study.
Topics: Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Treatment Outcome; Uric Acid | 2015 |
FLORENCE: a randomized, double-blind, phase III pivotal study of febuxostat versus allopurinol for the prevention of tumor lysis syndrome (TLS) in patients with hematologic malignancies at intermediate to high TLS risk.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Febuxostat; Female; Follow-Up Studies; Gout Suppressants; Hematologic Neoplasms; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Risk Factors; Tumor Lysis Syndrome; Uric Acid; Young Adult | 2015 |
The Effects of Allopurinol on the Carotid Intima-media Thickness in Patients with Type 2 Diabetes and Asymptomatic Hyperuricemia: A Three-year Randomized Parallel-controlled Study.
Topics: Adult; Aged; Allopurinol; Asian People; Atherosclerosis; Biomarkers; Blood Pressure; C-Reactive Protein; Carotid Intima-Media Thickness; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Gout Suppressants; Humans; Hyperuricemia; Incidence; Male; Middle Aged; Uric Acid | 2015 |
A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial.
Topics: Adult; Allopurinol; Blood Glucose; Blood Pressure Determination; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Chi-Square Distribution; Diet, Carbohydrate-Restricted; Female; Follow-Up Studies; Fructose; Humans; Male; Middle Aged; Overweight; Pilot Projects; Prehypertension; Risk Assessment; Treatment Outcome; Uric Acid | 2015 |
Pharmacokinetics, pharmacodynamics, and tolerability of LC350189, a novel xanthine oxidase inhibitor, in healthy subjects.
Topics: Adult; Area Under Curve; Biomarkers; Double-Blind Method; Drug Administration Schedule; Enzyme Inhibitors; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Republic of Korea; Uric Acid; Xanthine Oxidase; Young Adult | 2015 |
Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia.
Topics: Adult; Aged; Allopurinol; Asymptomatic Diseases; Biomarkers; Female; Humans; Hyperuricemia; Inflammation; Insulin Resistance; Male; Middle Aged; Prospective Studies; Uric Acid | 2015 |
Safety and efficacy of oral febuxostat for treatment of HLA-B*5801-negative gout: a randomized, open-label, multicentre, allopurinol-controlled study.
Topics: Administration, Oral; Adult; Alleles; Allopurinol; China; Febuxostat; Female; Gout; Gout Suppressants; HLA-B Antigens; Humans; Hyperuricemia; Male; Middle Aged; Treatment Outcome; Uric Acid | 2016 |
Benefits of Allopurinol Treatment on Blood Pressure and Renal Function in Patients with Early Stage of Chronic Kidney Disease.
Topics: Aged; Allopurinol; Biological Availability; Blood Pressure; Cardiovascular Diseases; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Male; Middle Aged; Patient Acuity; Prospective Studies; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid | 2015 |
Efficacy and safety of febuxostat for prevention of tumor lysis syndrome in patients with malignant tumors receiving chemotherapy: a phase III, randomized, multi-center trial comparing febuxostat and allopurinol.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Neoplasms; Thiazoles; Tumor Lysis Syndrome; Uric Acid; Xanthine Oxidase; Young Adult | 2016 |
Clinical efficacy and safety of topiroxostat in Japanese male hyperuricemic patients with or without gout: an exploratory, phase 2a, multicentre, randomized, double-blind, placebo-controlled study.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2016 |
Acute kidney injury observed during phase 1 clinical trials of a novel xanthine oxidase/URAT1 dual inhibitor PF-06743649.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Double-Blind Method; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; United States; Uric Acid; Xanthine Oxidase; Young Adult | 2016 |
Comparison of topiroxostat and allopurinol in Japanese hyperuricemic patients with or without gout: a phase 3, multicentre, randomized, double-blind, double-dummy, active-controlled, parallel-group study.
Topics: Adult; Aged; Allopurinol; Double-Blind Method; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2016 |
Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study.
Topics: Adult; Aged; Aged, 80 and over; Atherosclerosis; Carotid Artery, Common; Dose-Response Relationship, Drug; Enzyme Inhibitors; Febuxostat; Female; Humans; Hyperuricemia; Male; Middle Aged; Prospective Studies; Risk Factors; Uric Acid; Xanthine Oxidase; Young Adult | 2016 |
Patients with gout differ from healthy subjects in renal response to changes in serum uric acid.
Topics: Adult; Aged; Female; Gout; Gout Suppressants; Healthy Volunteers; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Uric Acid; Xanthine Oxidase; Young Adult | 2017 |
Rationale and design of the randomized evaluation of an Ambulatory Care Pharmacist-Led Intervention to Optimize Urate Lowering Pathways (RAmP-UP) Study.
Topics: Allopurinol; Ambulatory Care; Automation; Gout; Gout Suppressants; Humans; Patient Education as Topic; Pharmacists; Research Design; Telephone; Uric Acid | 2016 |
The effects of urate lowering therapy on inflammation, endothelial function, and blood pressure (SURPHER) study design and rationale.
Topics: Adolescent; Adult; Allopurinol; Black or African American; Blood Pressure; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Female; Gout Suppressants; Humans; Hyperuricemia; Inflammation Mediators; Male; Research Design; Sex Factors; Uric Acid; Young Adult | 2016 |
Therapeutic strategy for efficient reduction of serum uric acid levels with allopurinol versus benzbromarone in hyperuricemic patients with essential hypertension - A randomized crossover study (terao study).
Topics: Aged; Aged, 80 and over; Allopurinol; Benzbromarone; Drug Administration Schedule; Drug Monitoring; Enzyme Inhibitors; Essential Hypertension; Female; Humans; Hypertension; Hyperuricemia; Kidney Function Tests; Male; Middle Aged; Organic Anion Transporters; Stroke Volume; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2016 |
Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Creatinine; Double-Blind Method; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency; Retreatment; Symptom Flare Up; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents; Young Adult | 2017 |
Clinical efficacy and safety of topiroxostat in Japanese hyperuricemic patients with or without gout: a randomized, double-blinded, controlled phase 2b study.
Topics: Adult; Allopurinol; Double-Blind Method; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Male; Middle Aged; Nitriles; Pyridines; Treatment Outcome; Uric Acid; Young Adult | 2017 |
Effect of Uric Acid-Lowering Agents on Endothelial Function: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Adult; Allopurinol; Brachial Artery; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Female; Follow-Up Studies; Gout Suppressants; Humans; Hypertension; Male; Overweight; Probenecid; Time Factors; Treatment Outcome; Ultrasonography, Doppler; Uric Acid; Uricosuric Agents; Vasodilation | 2017 |
Allopurinol, benzbromarone and risk of coronary heart disease in gout patients: A population-based study.
Topics: Allopurinol; Benzbromarone; Coronary Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Incidence; Male; Middle Aged; Population Surveillance; Risk Factors; Taiwan; Treatment Outcome; Uric Acid; Uricosuric Agents | 2017 |
A randomised controlled trial of the efficacy and safety of allopurinol dose escalation to achieve target serum urate in people with gout.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Allopurinol; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Female; gamma-Glutamyltransferase; Gout; Gout Suppressants; Humans; Male; Middle Aged; Patient Care Planning; Treatment Outcome; Uric Acid | 2017 |
Effect of Uric Acid Lowering on Renin-Angiotensin-System Activation and Ambulatory BP: A Randomized Controlled Trial.
Topics: Adult; Allopurinol; Angiotensin II; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Boston; Double-Blind Method; Down-Regulation; Female; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Probenecid; Renin; Renin-Angiotensin System; Time Factors; Treatment Outcome; Uric Acid; Uricosuric Agents; Young Adult | 2017 |
New urate depositions on dual-energy computed tomography in gouty arthritis during urate-lowering therapy.
Topics: Acute Disease; Adult; Allopurinol; Arthritis, Gouty; Biomarkers; C-Reactive Protein; Febuxostat; Female; Foot Joints; Gout Suppressants; Humans; Male; Middle Aged; Statistics, Nonparametric; Tomography, X-Ray Computed; Uric Acid | 2017 |
Effect of Febuxostat on the Endothelial Dysfunction in Hemodialysis Patients: A Randomized, Placebo-Controlled, Double-Blinded Study.
Topics: Administration, Oral; Adult; Alanine Transaminase; Arginine; Aspartate Aminotransferases; C-Reactive Protein; Cardiovascular Diseases; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Febuxostat; Female; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Pancytopenia; Placebos; Prospective Studies; Renal Dialysis; Risk Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2017 |
An Open-Label Dose-Finding Study of Allopurinol to Target Defined Reduction in Urate Levels in Hemodialysis Patients.
Topics: Allopurinol; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Treatment Outcome; Uric Acid | 2017 |
Effect of apple polyphenols on vascular oxidative stress and endothelium function: a translational study.
Topics: Antioxidants; Blood Glucose; Body Mass Index; Cells, Cultured; Dietary Supplements; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Female; Human Umbilical Vein Endothelial Cells; Humans; Hyperuricemia; Male; Malus; Overweight; Oxidative Stress; Plant Extracts; Polyphenols; Prediabetic State; Uric Acid; Vascular Diseases; Vascular Resistance; Xanthine Oxidase | 2017 |
Allopurinol Against Progression of Chronic Kidney Disease.
Topics: Allopurinol; Biomarkers; Disease Progression; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Iran; Kidney; Male; Middle Aged; Renal Insufficiency, Chronic; Time Factors; Treatment Outcome; Uric Acid | 2017 |
Allopurinol dose escalation to achieve serum urate below 6 mg/dL: an open-label extension study.
Topics: Aged; Allopurinol; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Time Factors; Treatment Outcome; Uric Acid | 2017 |
Effectiveness of an electronic patient-centred self-management tool for gout sufferers: a cluster randomised controlled trial protocol.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Internet; Patient Compliance; Prospective Studies; Quality of Life; Research Design; Self-Management; Uric Acid | 2017 |
Effect of Febuxostat on Ambulatory Blood Pressure in Subjects With Hyperuricemia and Hypertension: A Phase 2 Randomized Placebo-Controlled Study.
Topics: Adult; Aged; Antihypertensive Agents; Biomarkers; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Double-Blind Method; Enzyme Inhibitors; Febuxostat; Female; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; North America; Proof of Concept Study; Prospective Studies; Time Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2017 |
The effect of kidney function on the urate lowering effect and safety of increasing allopurinol above doses based on creatinine clearance: a post hoc analysis of a randomized controlled trial.
Topics: Adult; Aged; Allopurinol; Creatinine; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Uric Acid | 2017 |
The effect of uric acid lowering treatment on albuminuria and renal function in Type 1 diabetes: a randomized clinical trial.
Topics: Albuminuria; Allopurinol; Creatinine; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Renal Agents; Uric Acid | 2018 |
Effect of allopurinol on the glomerular filtration rate of children with chronic kidney disease.
Topics: Adolescent; Allopurinol; Child; Child, Preschool; Disease Progression; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Kidney; Male; Prospective Studies; Renal Insufficiency, Chronic; Risk Factors; Treatment Outcome; Uric Acid | 2018 |
Design and Rationale for the Veterans Affairs "Cooperative Study Program 594 Comparative Effectiveness in Gout: Allopurinol vs. Febuxostat" Trial.
Topics: Adult; Allopurinol; Dose-Response Relationship, Drug; Double-Blind Method; Drug Dosage Calculations; Drug Monitoring; Febuxostat; Gout; Gout Suppressants; Humans; Male; Medication Therapy Management; Middle Aged; Practice Guidelines as Topic; Treatment Outcome; United States; United States Department of Veterans Affairs; Uric Acid; Veterans Health | 2018 |
The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout.
Topics: Adult; Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Thioglycolates; Triazoles; Uric Acid | 2018 |
Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Multiple Dose Administration of Verinurad (RDEA3170) and Allopurinol in Adult Male Subjects With Gout.
Topics: Adolescent; Adult; Aged; Allopurinol; Area Under Curve; Drug Administration Schedule; Gout; Gout Suppressants; Humans; Male; Middle Aged; Naphthalenes; Oxypurinol; Propionates; Pyridines; Uric Acid; Young Adult | 2018 |
Can we predict inadequate response to allopurinol dose escalation? Analysis of a randomised controlled trial.
Topics: Allopurinol; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Treatment Outcome; Uric Acid | 2018 |
The efficacy of febuxostat and allopurinol in the treatment of gout with hyperuricemia.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Double-Blind Method; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Treatment Outcome; Uric Acid | 2018 |
Efficacy and cost-effectiveness of nurse-led care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial.
Topics: Aged; Allopurinol; Cost-Benefit Analysis; Disease Management; England; Female; General Practice; Gout; Gout Suppressants; Humans; Longitudinal Studies; Male; Medication Adherence; Middle Aged; Practice Patterns, Nurses'; Quality-Adjusted Life Years; Surveys and Questionnaires; Uric Acid | 2018 |
Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Allopurinol; Carotid Intima-Media Thickness; Chronic Kidney Disease-Mineral and Bone Disorder; Double-Blind Method; Female; Fibroblast Growth Factor-23; Humans; Kidney Failure, Chronic; Male; Middle Aged; Parathyroid Hormone; Renal Insufficiency, Chronic; Uric Acid; Vascular Calcification; Vitamin D; Young Adult | 2018 |
Implication of nurse intervention on engagement with urate-lowering drugs: A qualitative study of participants in a RCT of nurse led care.
Topics: Allopurinol; Clinical Competence; Decision Making, Shared; Female; France; Gout; Gout Suppressants; Humans; Interviews as Topic; Male; Medication Adherence; Nurse-Patient Relations; Patient Satisfaction; Practice Patterns, Nurses'; Qualitative Research; Risk Assessment; Severity of Illness Index; Treatment Outcome; Uric Acid | 2019 |
How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose.
Topics: Adult; Aged; Allopurinol; Creatinine; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Gout; Gout Suppressants; Humans; Male; Metabolic Clearance Rate; Middle Aged; Uric Acid | 2018 |
Adherence and Outcomes with Urate-Lowering Therapy: A Site-Randomized Trial.
Topics: Adult; Aged; Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Middle Aged; Odds Ratio; Patient Participation; Pharmacists; Professional Role; Telephone; Treatment Outcome; Uric Acid | 2019 |
Effects of Allopurinol Dose Escalation on Bone Erosion and Urate Volume in Gout: A Dual-Energy Computed Tomography Imaging Study Within a Randomized, Controlled Trial.
Topics: Aged; Allopurinol; Bone Resorption; Dose-Response Relationship, Drug; Female; Foot Bones; Foot Joints; Gout; Gout Suppressants; Hand Bones; Hand Joints; Humans; Male; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome; Uric Acid | 2019 |
Relationships Between Allopurinol Dose, Oxypurinol Concentration and Urate-Lowering Response-In Search of a Minimum Effective Oxypurinol Concentration.
Topics: Aged; Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; Body Mass Index; Creatinine; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Neoplasm Proteins; Oxypurinol; Renal Elimination; ROC Curve; Treatment Outcome; Uric Acid | 2020 |
The effect for hyperuricemia inpatient of uric acid overproduction type or in combination with topiroxostat on the pharmacokinetics, pharmacodynamics and safety of dotinurad, a selective urate reabsorption inhibitor.
Topics: Adult; Aged; Benzothiazoles; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Hyperuricemia; Inpatients; Middle Aged; Nitriles; Pyridines; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2020 |
Changeover Trial of Febuxostat and Topiroxostat for Hyperuricemia with Cardiovascular Disease: Sub-Analysis for Chronic Kidney Disease (TROFEO CKD Trial).
Topics: Aged; Antioxidants; Biomarkers; Cross-Over Studies; Down-Regulation; Enzyme Inhibitors; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Nitriles; Pyridines; Renal Insufficiency, Chronic; Time Factors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2020 |
Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study.
Topics: Adult; Blood Pressure; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular; Febuxostat; Humans; Male; Microvessels; Severity of Illness Index; Urate Oxidase; Uric Acid; Vasodilation; Xanthine Oxidase; Young Adult | 2019 |
Lack of effect of tart cherry concentrate dose on serum urate in people with gout.
Topics: Adult; Aged; Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Phytotherapy; Plant Extracts; Prunus avium; Treatment Outcome; Uric Acid | 2020 |
Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes.
Topics: Adult; Aged; Allopurinol; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Double-Blind Method; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Renin-Angiotensin System; Treatment Failure; Uric Acid; Xanthine Oxidase | 2020 |
Effects of Allopurinol on the Progression of Chronic Kidney Disease.
Topics: Aged; Allopurinol; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Progression; Double-Blind Method; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Renin-Angiotensin System; Treatment Failure; Uric Acid; Xanthine Oxidase | 2020 |
Randomized, Open-Label, Cross-Over Comparison of the Effects of Benzbromarone and Febuxostat on Endothelial Function in Patients with Hyperuricemia.
Topics: Adiponectin; Aged; Arginine; Benzbromarone; Cross-Over Studies; Endothelium, Vascular; Febuxostat; Female; Gout Suppressants; Humans; Hyperemia; Hyperuricemia; Male; Middle Aged; Organic Anion Transporters; Organic Cation Transport Proteins; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2020 |
Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial.
Topics: Aged; Allopurinol; Cardiovascular Diseases; Denmark; Febuxostat; Female; Gout; Gout Suppressants; Hospitalization; Humans; Male; Prospective Studies; Sweden; Treatment Outcome; United Kingdom; Uric Acid | 2020 |
Effects of intensive urate lowering therapy with febuxostat in comparison with allopurinol on pulse wave velocity in patients with gout and increased cardiovascular risk: the FORWARD study.
Topics: Adult; Allopurinol; Cardiovascular Diseases; Febuxostat; Gout; Gout Suppressants; Heart Disease Risk Factors; Humans; Pulse Wave Analysis; Risk Factors; Thiazoles; Treatment Outcome; Uric Acid | 2022 |
Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure.
Topics: Aged; Allopurinol; Female; Free Radical Scavengers; Heart Failure; Humans; Hyperuricemia; Male; Methylation; Middle Aged; Oxidation-Reduction; Precision Medicine; S-Adenosylhomocysteine; S-Adenosylmethionine; Stroke Volume; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2021 |
Effect of Serum Urate Lowering With Allopurinol on Blood Pressure in Young Adults: A Randomized, Controlled, Crossover Trial.
Topics: Adolescent; Adult; Allopurinol; Blood Pressure; C-Reactive Protein; Cross-Over Studies; Dilatation, Pathologic; Double-Blind Method; Endothelium, Vascular; Female; Gout; Humans; Hypertension; Male; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid; Uricosuric Agents; Young Adult | 2021 |
Allopurinol for fibromyalgia pain in adults: A randomized controlled trial.
Topics: Allopurinol; Animals; Double-Blind Method; Female; Fibromyalgia; Gout Suppressants; Humans; Pain; Prospective Studies; Treatment Outcome; Uric Acid | 2022 |
Early versus Late Allopurinol Initiation in Acute Gout Flare (ELAG): a randomized controlled trial.
Topics: Allopurinol; Double-Blind Method; Gout; Gout Suppressants; Humans; Symptom Flare Up; Time-to-Treatment; Treatment Outcome; Uric Acid | 2022 |
Pharmacokinetic/Pharmacodynamic Modelling of Allopurinol, its Active Metabolite Oxypurinol, and Biomarkers Hypoxanthine, Xanthine and Uric Acid in Hypoxic-Ischemic Encephalopathy Neonates.
Topics: Allopurinol; Biomarkers; Enzyme Inhibitors; Humans; Hypoxanthine; Hypoxia-Ischemia, Brain; Infant, Newborn; Oxypurinol; Uric Acid; Xanthine; Xanthine Oxidase | 2022 |
Comparison between febuxostat and allopurinol uric acid-lowering therapy in patients with chronic heart failure and hyperuricemia: a multicenter randomized controlled trial.
Topics: Allopurinol; Febuxostat; Heart Failure; Humans; Hyperuricemia; Uric Acid | 2021 |
Intensive Serum Urate Lowering With Oral Urate-Lowering Therapy for Erosive Gout: A Randomized Double-Blind Controlled Trial.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Quality of Life; Treatment Outcome; Uric Acid | 2022 |
Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid atherosclerosis: a subanalysis of the PRIZE study.
Topics: Ankle Brachial Index; Atherosclerosis; Awards and Prizes; Carotid Artery Diseases; Enzyme Inhibitors; Febuxostat; Humans; Hyperuricemia; Prospective Studies; Pulse Wave Analysis; Uric Acid; Vascular Stiffness; Xanthine Oxidase | 2022 |
Effect of allopurinol drug use on GFR and proteinuria in patients with renal transplant recipients (ADOPTR study).
Topics: Allopurinol; C-Reactive Protein; Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Kidney Transplantation; Proteinuria; Treatment Outcome; Uric Acid | 2022 |
Evaluation of the Relationship Between Serum Urate Levels, Clinical Manifestations of Gout, and Death From Cardiovascular Causes in Patients Receiving Febuxostat or Allopurinol in an Outcomes Trial.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Thiazoles; Treatment Outcome; Uric Acid | 2022 |
Long-Term Follow-up of a Randomized Controlled Trial of Allopurinol Dose Escalation to Achieve Target Serum Urate in People With Gout.
Topics: Allopurinol; Follow-Up Studies; Gout; Gout Suppressants; Humans; Symptom Flare Up; Treatment Outcome; Uric Acid | 2022 |
Superiority of Low-Dose Benzbromarone to Low-Dose Febuxostat in a Prospective, Randomized Comparative Effectiveness Trial in Gout Patients With Renal Uric Acid Underexcretion.
Topics: Allopurinol; Benzbromarone; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Prospective Studies; Treatment Outcome; Uric Acid | 2022 |
Impact of febuxostat on visit-to-visit blood pressure variability: insights from the randomised PRIZE Study.
Topics: Awards and Prizes; Blood Pressure; Carotid Intima-Media Thickness; Febuxostat; Humans; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2022 |
A Drug-Drug Interaction Study of a Novel Selective Urate Reabsorption Inhibitor, SHR4640, and Xanthine Oxidase Inhibitor, Febuxostat, in Patients With Primary Hyperuricemia.
Topics: Drug Interactions; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2023 |
Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.
Topics: Aged; Allopurinol; Coronary Artery Disease; Female; Gout; Humans; Male; Myocardial Infarction; Myocardial Ischemia; Prospective Studies; Stroke; Treatment Outcome; United Kingdom; Uric Acid | 2022 |
Low-dose febuxostat exhibits a superior renal-protective effect and non-inferior safety profile compared to allopurinol in chronic kidney disease patients complicated with hyperuricemia: A double-centre, randomized, controlled study.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid | 2022 |
Verinurad does not prolong QTc interval: a thorough QT study using concentration-QTc modelling.
Topics: Allopurinol; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Long QT Syndrome; Moxifloxacin; Uric Acid | 2023 |
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial.
Topics: Adult; Allopurinol; Colchicine; Gout; Gout Suppressants; Humans; Symptom Flare Up; Treatment Outcome; Uric Acid | 2023 |
1819 other study(ies) available for uric acid and allopurinol
| Article | Year |
|---|---|
Oxidation of N-methyl substituted hypoxanthines, xanthines, purine-6,8-diones and the corresponding 6-thioxo derivatives by bovine milk xanthine oxidase.
Topics: Animals; Binding Sites; Cattle; Hydrogen-Ion Concentration; Hypoxanthines; Kinetics; Methane; Milk; Protein Binding; Purines; Purinones; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase; Xanthines | 1976 |
Dissolution of renal uric acid calculus with allopurinal and alkalization of urine: a case report.
Topics: Acetazolamide; Allopurinol; Bicarbonates; Citrates; Drug Combinations; Gout; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Male; Middle Aged; Uric Acid; Urine | 1976 |
In situ dissolution of ureteral calculus.
Topics: Allopurinol; Bicarbonates; Female; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Middle Aged; Radiography; Therapeutic Irrigation; Ureteral Calculi; Ureteral Obstruction; Uric Acid; Urinary Catheterization | 1976 |
Physiological characteristics of various experimental models for the study of disorders in purine metabolism.
Topics: Acidosis; Alkalosis; Allopurinol; Animals; Cholesterol; Disease Models, Animal; Diuresis; Fructose; Glycine; Gout; Hydrogen-Ion Concentration; Natriuresis; Oxonic Acid; Probenecid; Purines; Rats; Research Design; Species Specificity; Triazines; Triglycerides; Uric Acid | 1977 |
[Indications and methods of urolitholysis therapy].
Topics: Allopurinol; Citrates; Cystine; Humans; Hydrogen-Ion Concentration; Uric Acid; Urinary Calculi; Urine | 1977 |
[Basic therapy in children with leukemia and a malignant tumors. II].
Topics: Allopurinol; Anaphylaxis; Anemia; Antibiotics, Antineoplastic; Bicarbonates; Blood Transfusion; Child; Child, Preschool; Cystitis; Disseminated Intravascular Coagulation; Erythrocytes; Female; Furosemide; Heart Arrest; Heparin; Humans; Hydrogen-Ion Concentration; Kidney; Leukemia; Lung Diseases; Male; Mercaptopurine; Mutation; Neoplasms; Phospholipids; Renal Dialysis; Thrombocytopenia; Uric Acid | 1978 |
[Drug therapy and metaphylaxis of urolithiasis].
Topics: Alkalies; Citrates; Diuresis; Fluid Therapy; Gout; Humans; Hydrogen-Ion Concentration; Recurrence; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1978 |
[Drug therapy of uric acid calculi--litholysis].
Topics: Aged; Allopurinol; Bicarbonates; Female; Humans; Hydrogen-Ion Concentration; Male; Uric Acid; Urinary Calculi | 1979 |
[The care of patients with urate calculi].
Topics: Allopurinol; Citrates; Diet Therapy; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Magnesium; Pyridoxine; Solubility; Uric Acid; Urinary Calculi; Urine | 1979 |
Letter: Treatment of malignant haemopathies and urate oxidase.
Topics: Allopurinol; Humans; Leukemia; Multiple Myeloma; Urate Oxidase; Uric Acid | 1975 |
The gout-calcium-stone connection.
Topics: Allopurinol; Calcium Oxalate; Gout; Humans; Kidney Calculi; Uric Acid | 1979 |
[Digestive tract and uric acid metabolism].
Topics: Biological Transport; Fructose; Humans; Intestinal Mucosa; Intestine, Small; Liver; Purines; Uric Acid; Xanthine Oxidase | 1979 |
Studies on the stability of immobilized xanthine oxidase and urate oxidase.
Topics: Enzymes, Immobilized; Glutaral; Humans; Hypoxanthines; Methods; Protein Denaturation; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1978 |
[The uric acid-lowering action of benzbromarone effervescent granules and allopurinol. Comparative studies (author's transl)].
Topics: Adult; Aged; Allopurinol; Benzbromarone; Benzofurans; Dosage Forms; Female; Humans; Male; Middle Aged; Uric Acid; Uricosuric Agents | 1978 |
[Uric acid stones in children. Identification and therapy of a newly detected defect of adenine-phosphoribosyltransferase (author's transl)].
Topics: Adenine Phosphoribosyltransferase; Allopurinol; Child; Diet Therapy; Female; Homozygote; Humans; Male; Pentosyltransferases; Purines; Solubility; Uric Acid; Urinary Calculi | 1979 |
Ampicillin rash and hyperuricemia.
Topics: Allopurinol; Ampicillin; Drug Eruptions; Drug Interactions; Humans; Immunosuppression Therapy; Neoplasms; Risk; Uric Acid | 1979 |
[Duplication of the left atrioventricular orifice (author's transl)].
Topics: Adult; Allopurinol; Arrhythmias, Cardiac; Blood Glucose; Cardiomegaly; Cholesterol; Diphosphates; Electrocardiography; Heart Defects, Congenital; Humans; Lipids; Male; Orotic Acid; Phosphates; Phospholipids; Ribose; Triglycerides; Uric Acid; Uricosuric Agents | 1975 |
Von Gierke's disease: a review.
Topics: Allopurinol; Bicarbonates; Blood Glucose; Diazoxide; Gluconeogenesis; Glucose-6-Phosphatase; Glycogen; Glycogen Storage Disease Type I; Growth Disorders; Humans; Hypoglycemia; Liver; Liver Glycogen; Uric Acid | 1976 |
Electron-paramagnetic-resonance spectroscopy of complexes of xanthine oxidase with xanthine and uric acid.
Topics: Animals; Chemical Phenomena; Chemistry; Computers; Electron Spin Resonance Spectroscopy; Milk; Purines; Uric Acid; Xanthine Oxidase; Xanthines | 1978 |
Dietary feedback regulation of purine and pyrimidine biosynthesis in man.
Topics: Allopurinol; Diet; Feedback; Glycine; Humans; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purine Nucleotides; Purines; Pyrimidine Nucleotides; RNA; Uric Acid; Uridine Monophosphate | 1977 |
Purine and pyrimidine metabolism.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Ascorbic Acid; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Methylene Blue; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Ribosemonophosphates; Uric Acid | 1977 |
Cardiac arrest due to hyperkalemia following therapy for acute lymphoblastic leukemia.
Topics: Adolescent; Allopurinol; Daunorubicin; Drug Therapy, Combination; Heart Arrest; Humans; Hyperkalemia; Leukemia, Lymphoid; Male; Prednisone; Uric Acid; Vinblastine; Vincristine | 1977 |
Renal excretion of uric acid and its relation to relapse and remission in acute myeloid leukaemia.
Topics: Adolescent; Adult; Aged; Allopurinol; Creatinine; Female; Homeostasis; Humans; Kidney; Kidney Tubules; Leukemia, Myeloid, Acute; Male; Middle Aged; Pyrazinamide; Recurrence; Remission, Spontaneous; Uric Acid | 1977 |
[Acute hyperuricemia as an oncological emergency].
Topics: Adult; Allopurinol; Daunorubicin; Drug Therapy, Combination; Humans; L-Lactate Dehydrogenase; Leukemia, Myeloid, Acute; Male; Prednisone; Uric Acid | 1978 |
[Physiopathological bases for a rational therapy of gout].
Topics: Allopurinol; Benzofurans; Gout; Humans; Life Style; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1978 |
The Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Adolescent; Aggression; Allopurinol; Behavior Therapy; Child; Child Behavior Disorders; Child Development; Child, Preschool; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Lesch-Nyhan Syndrome; Male; Restraint, Physical; Self Mutilation; Stereotyped Behavior; Uric Acid | 1978 |
[The treatment of hyperuricemia after kidney transplantation].
Topics: Allopurinol; Azathioprine; Benzbromarone; Creatinine; Drug Interactions; Female; Humans; Kidney Transplantation; Male; Transplantation, Homologous; Uric Acid; Urinary Calculi | 1977 |
Hyperuricemia and gout. A modern approach to diagnosis and treatment.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Gout; Humans; Uric Acid | 1979 |
[Hypouricemia and xanthinuria. Observation of 3 cases].
Topics: Adult; Aged; Female; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Oxidase; Xanthines | 1979 |
Drug therapy reviews: pathogenesis and clinical management of hyperuricemia and gout.
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents; Arthritis; Chronic Disease; Colchicine; Gout; Humans; Kidney Diseases; Uric Acid; Uricosuric Agents | 1979 |
Management of gout.
Topics: Adrenal Cortex Hormones; Allopurinol; Colchicine; Female; Gout; Humans; Indomethacin; Patient Education as Topic; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1979 |
Mechanism and treatment of hypertriglyceridaemia in gout.
Topics: Alcohol Drinking; Allopurinol; Cholesterol; Gout; Humans; Hyperlipidemias; Male; Middle Aged; Obesity; Probenecid; Triglycerides; Uric Acid | 1979 |
Allopurinol in the prevention of calcium oxalate renal stones. Preliminary results.
Topics: Adult; Aged; Allopurinol; Calcium Oxalate; Female; Humans; Kidney Calculi; Male; Middle Aged; Uric Acid | 1979 |
Management of gout.
Topics: Acute Disease; Allopurinol; Gout; Gout Suppressants; Humans; Methods; Uric Acid; Uricosuric Agents | 1979 |
Hyperxanthinemia interferes with serum uric acid determinations by the uricase method.
Topics: Adult; Allopurinol; Burkitt Lymphoma; Colorimetry; Humans; Indicators and Reagents; Male; Urate Oxidase; Uric Acid; Xanthines | 1979 |
[Treatment of oncologic emergencies after cytostatic therapy].
Topics: Allopurinol; Blood Platelets; Blood Transfusion; Breast Neoplasms; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Leukopenia; Middle Aged; Patient Isolation; Thrombocytopenia; Uric Acid | 1979 |
Effect of allopurinol (zyloric) on patients undergoing open heart surgery.
Topics: Allopurinol; Cardiac Surgical Procedures; Glucuronidase; Heart Septal Defects; Heart Valve Diseases; Humans; Lactates; Myocardial Contraction; Postoperative Period; Preoperative Care; Pyruvates; Uric Acid | 1979 |
Chronic gouty nephropathy treated by long-term hemodialysis and allopurinol.
Topics: Allopurinol; Gout; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Time Factors; Uric Acid | 1979 |
Serum xanthine oxidase in bladder carcinoma.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Neoplasm Staging; Uric Acid; Urinary Bladder Neoplasms; Xanthine Oxidase | 1979 |
[The conservative therapy of urolithiasis (author's transl)].
Topics: Allopurinol; Aluminum Hydroxide; Calcium; Cystine; Humans; Ion Exchange; Magnesium; Oxalates; Phosphates; Pyridoxine; Quaternary Ammonium Compounds; Succinimides; Uric Acid; Urinary Calculi | 1979 |
[Therapy of gout].
Topics: Allopurinol; Arteriosclerosis; Benzbromarone; Colchicine; Gout; Humans; Immobilization; Indomethacin; Uric Acid | 1979 |
The effect of Milurit on secondary hyperuricaemia following cytostatic treatment in haemoblastosis patients.
Topics: Adolescent; Adult; Aged; Allopurinol; Antineoplastic Agents; Child; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Lymphoma; Middle Aged; Polycythemia Vera; Pregnancy; Uric Acid | 1979 |
Tienilic acid in hypertension with hyperuricaemia.
Topics: Allopurinol; Bendroflumethiazide; Creatinine; Female; Glycolates; Gout; Humans; Hypertension; Male; Ticrynafen; Uric Acid | 1979 |
Allopurinol toxicity.
Topics: Allopurinol; Gout; Hematologic Diseases; Humans; Kidney Diseases; Uric Acid | 1979 |
[Early diagnosis of gout].
Topics: Adult; Allopurinol; Efficiency; Female; Gout; Humans; Kidney Diseases; Male; Middle Aged; Nephrocalcinosis; Prognosis; Synovial Membrane; Uric Acid | 1979 |
[Hypouricaemia (author's transl)].
Topics: Allopurinol; Fanconi Syndrome; Humans; Liver Diseases; Neoplasms; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthines | 1979 |
[Outpatient care in uric acid disorders].
Topics: Adult; Aged; Alcohol Drinking; Allopurinol; Ambulatory Care; Female; Humans; Male; Metabolic Diseases; Middle Aged; Obesity; Uric Acid | 1979 |
[Allomaron in hyperuricemia and gout].
Topics: Adolescent; Adult; Aged; Allopurinol; Benzbromarone; Benzofurans; Drug Combinations; Drug Evaluation; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1979 |
[Litholysis of uric acid stones by peroral therapy (author's transl)].
Topics: Aged; Allopurinol; Female; Humans; Piperazines; Uric Acid; Urinary Calculi | 1979 |
Urate metabolism and gastric ulcerations in rats as influenced by stress and allopurinol.
Topics: Allopurinol; Animals; Gastric Juice; Humans; Male; Microcirculation; Rats; Stomach; Stomach Ulcer; Stress, Psychological; Uric Acid | 1978 |
Massive hepatic necrosis in a patient receiving allopurinol.
Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Middle Aged; Necrosis; Pruritus; Uric Acid; Urticaria | 1977 |
[On the dose-effect relation of allopurinol (author's transl)].
Topics: Adult; Aged; Allopurinol; Delayed-Action Preparations; Dose-Response Relationship, Drug; Gout; Humans; Middle Aged; Time Factors; Uric Acid | 1977 |
[Modern differential-therapeutic aspects of the drug therapy of chronic gout].
Topics: Allopurinol; Arteriosclerosis; Citrates; Gout; Humans; Hypertension; Kidney Diseases; Obesity; Phenylbutazone; Uric Acid; Urinary Calculi | 1979 |
Fluorometric determination of xanthine and hypoxanthine in tissue.
Topics: Animals; Catalase; Horseradish Peroxidase; Hypoxanthines; Liver; Male; Rats; Spectrometry, Fluorescence; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1979 |
Simultaneous analysis of substrates, products, and inhibitors of xanthine oxidase by high-pressure liquid chromatography and gas chromatography.
Topics: Allopurinol; Chromatography, Gas; Chromatography, High Pressure Liquid; Humans; Hypoxanthines; Neoplasms; Oxypurinol; Uric Acid; Xanthine Oxidase; Xanthines | 1979 |
Transport of uric acid and hypoxanthine across the isolated guinea pig placenta.
Topics: Animals; Female; Guinea Pigs; Hypoxanthines; Maternal-Fetal Exchange; Placenta; Pregnancy; Uric Acid; Uterus; Xanthine Oxidase | 1977 |
Serum xanthine oxidase in carcinoma breast.
Topics: Adult; Breast Neoplasms; Female; Humans; Middle Aged; Uric Acid; Xanthine Oxidase | 1977 |
Evaluation of once a day allopurinol administration in man.
Topics: Allopurinol; Drug Administration Schedule; Evaluation Studies as Topic; Humans; Uric Acid | 1978 |
Folic acid, xanthine oxidase, and uric acid.
Topics: Folic Acid; Gout; Humans; Uric Acid; Xanthine Oxidase | 1978 |
Acute renal failure in patients with acute leukemia.
Topics: Acute Disease; Acute Kidney Injury; Adult; Allopurinol; Female; Hemorrhage; Humans; Kidney Diseases; Kidney Tubular Necrosis, Acute; Leukemia; Male; Middle Aged; Uric Acid | 1978 |
Serum uric acid determined by reversed-phase liquid chromatography with spectrophotometric detection.
Topics: Acetaminophen; Allopurinol; Chromatography, Liquid; Drug Interactions; Humans; Methods; Oxypurinol; Salicylates; Spectrophotometry, Ultraviolet; Theophylline; Urate Oxidase; Uric Acid | 1978 |
[Use of the uricosuric preparations and allopurinol in children with uratic nephropathies].
Topics: Adolescent; Allopurinol; Child; Child, Preschool; Drug Therapy, Combination; Humans; Nephritis; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Uricosuric Agents | 1978 |
Nephrolithiasis in patients with gout.
Topics: Allopurinol; Gout; Humans; Kidney Calculi; Recurrence; Uric Acid | 1978 |
Allpurinol hypersensitivity syndrome: effects and treatment.
Topics: Adult; Aged; Allopurinol; Drug Hypersensitivity; Female; Humans; Male; Middle Aged; Syndrome; Uric Acid | 1978 |
Liver granulomas and allopurinol.
Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Granuloma, Giant Cell; Humans; Male; Middle Aged; Uric Acid | 1978 |
Prevention of recurrences in uric acid nephrolithiasis.
Topics: Adult; Allopurinol; Citrates; Humans; Kidney Calculi; Potassium; Purines; Recurrence; Sodium; Time Factors; Uric Acid | 1978 |
Allopurinol-induced myocardial and renal damage in nonarteriosclerotic (virgin) and arteriosclerotic (breeder) Sprague-Dawley rats.
Topics: Allopurinol; Animals; Arteriosclerosis; Blood Glucose; Blood Urea Nitrogen; Breeding; Corticosterone; Enzymes; Heart; Kidney; Lipids; Liver; Male; Myocardial Infarction; Pancreas; Rats; Uric Acid | 1978 |
A two-stage enzymatic method for determination of uric acid and hypoxanthine/xanthine.
Topics: Humans; Hypoxanthines; Ischemia; Methods; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1978 |
Purine biosynthesis de novo by lymphocytes in gout.
Topics: Adult; Allopurinol; Female; Gout; Humans; In Vitro Techniques; Kidney Diseases; Lymphocytes; Male; Middle Aged; Purines; Ribonucleotides; Uric Acid | 1978 |
[Blood uric acid levels as an indicator of the response to physical loads].
Topics: Adenosine Triphosphate; Allantoin; Animals; Liver; Muscles; Physical Exertion; Rats; Time Factors; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1978 |
Hyperuricosuric calcium oxalate nephrolithiasis.
Topics: Adolescent; Adult; Age Factors; Aged; Allopurinol; Calcium; Child; Child, Preschool; Crystallization; Diet; Female; Humans; Infant; Infant, Newborn; Kidney Calculi; Male; Middle Aged; Oxalates; Purines; Syndrome; Uric Acid | 1978 |
Calcium-uric acid nephrolithiasis.
Topics: Adult; Aged; Allopurinol; Calcium; Female; Humans; Kidney Calculi; Male; Middle Aged; Recurrence; Time Factors; Trichlormethiazide; Uric Acid | 1978 |
[Juvenile gout with decreased activity of hypoxanthine-guanine-phosphoribosyl transferase and pheochromocytoma: partial persistence of tophi despite uric-acid reducing treatment for 12 years (author's transl)].
Topics: Adrenal Gland Neoplasms; Allopurinol; Gout; Humans; Hypertension, Malignant; Hypoxanthine Phosphoribosyltransferase; Kidney Calculi; Male; Middle Aged; Pheochromocytoma; Uric Acid | 1978 |
Dissolution of bilateral uric acid calculi causing anuria.
Topics: Adult; Allopurinol; Anuria; Bicarbonates; Humans; Kidney Calculi; Kidney Pelvis; Male; Therapeutic Irrigation; Uric Acid; Urinary Catheterization | 1978 |
[Xanthinuria (author's transl)].
Topics: Adolescent; Adult; Child; Female; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Urinary Calculi; Xanthine Oxidase; Xanthines | 1978 |
[The influence of allopurinol on purine- and pyrimidinesynthesis (author's transl)].
Topics: Allopurinol; Humans; Hypoxanthines; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Purines; Pyrimidines; Uric Acid; Xanthine Oxidase; Xanthines | 1978 |
Asymptomatic hyperuricemia.
Topics: Allopurinol; Costs and Cost Analysis; Humans; Uric Acid | 1978 |
[Gout - a surgical problem].
Topics: Allopurinol; Benzbromarone; Female; Gout; Hand; Humans; Middle Aged; Patient Care Team; Uric Acid | 1978 |
Treatment of gout with alternate-day hypo-uricaemic drugs.
Topics: Adult; Aged; Allopurinol; Benzbromarone; Benzofurans; Female; Gout; Humans; Male; Middle Aged; Sulfinpyrazone; Uric Acid | 1978 |
Effect of oral purine load and allopurinol on the crystallization of calcium salts in urine of patients with hyperuricosuric calcium urolithiasis.
Topics: Allopurinol; Calcium Oxalate; Crystallization; Diet; Humans; Kidney Calculi; Male; Purines; Sodium; Uric Acid | 1978 |
Effect of a xanthine oxidase inhibitor on adenine nucleotide degradation in hemorrhagic shock.
Topics: Acid Phosphatase; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Allantoin; Allopurinol; Animals; Dogs; Duodenum; Glucuronidase; Liver; Pancreas; Shock, Hemorrhagic; Uric Acid; Xanthine Oxidase | 1978 |
Allantoxanamide: a potent new uricase inhibitor in vivo.
Topics: Animals; Female; Kidney Tubules; Oxonic Acid; Rats; Time Factors; Triazines; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1978 |
The effect of allopurinol on urinary oxalate excretion in stone formers.
Topics: Allopurinol; Female; Follow-Up Studies; Humans; Male; Oxalates; Uric Acid; Urinary Calculi | 1978 |
[Uric-acid reduction with high allopurinol dosages (author's transl)].
Topics: Aged; Allopurinol; Dose-Response Relationship, Drug; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1979 |
[The significance of uric acid in calcium oxalate nephrolithiasis].
Topics: Adult; Aged; Allopurinol; Calcium; Creatinine; Female; Humans; Kidney Calculi; Male; Middle Aged; Oxalates; Phosphorus; Uric Acid; Uricosuric Agents | 1975 |
Renal urate excretion in animal models.
Topics: Allopurinol; Animals; Carboxylic Acids; Dogs; Goats; Haplorhini; Humans; Kidney; Kidney Tubules, Proximal; Male; Mersalyl; Pan troglodytes; Probenecid; Pyrazines; Uric Acid | 1975 |
3,5-disubstituted 1,2,3,4-triazoles, 1 new class of xanthine oxidase inhibitor.
Topics: Aerobiosis; Allantoin; Anaerobiosis; Animals; Dogs; Enterohepatic Circulation; Ferritins; Haplorhini; Hylobates; Hypoxanthines; Kinetics; Oxidation-Reduction; Polynucleotides; Rats; Saimiri; Species Specificity; Triazoles; Uric Acid; Xanthine Oxidase | 1975 |
The purine nucleotide cycle. A pathway for ammonia production in the rat kidney.
Topics: Adenine Nucleotides; Allopurinol; Ammonia; Ammonium Chloride; AMP Deaminase; Animals; Aspartic Acid; Edetic Acid; Hypokalemia; In Vitro Techniques; Inosine Nucleotides; Kidney; Kidney Cortex; Male; Purine Nucleotides; Rats; Tissue Extracts; Uric Acid | 1976 |
Xanthine oxidase and guanase activities in normal and psoriatic epidermis.
Topics: Adult; Aged; Aminohydrolases; Female; Guanine Deaminase; Humans; Male; Middle Aged; Psoriasis; Skin; Uric Acid; Xanthine Oxidase | 1977 |
Inhibition of urate production by allopurinol.
Topics: 2,6-Dichloroindophenol; Allopurinol; Animals; Humans; Kidney; Kinetics; Oxypurinol; Uric Acid; Xanthine Oxidase | 1977 |
Purine enzyme abnormalities: a four year experience.
Topics: Adenine Phosphoribosyltransferase; Adolescent; Adult; Child; Erythrocytes; Female; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Kidney Calculi; Male; Pentosyltransferases; Uric Acid; Xanthine Oxidase | 1977 |
Carbohydrate induced increase in uric acid synthesis. Studies in human volunteers and in laboratory rats.
Topics: Adenine Nucleotides; Allopurinol; Animals; Carbohydrates; Dose-Response Relationship, Drug; Fructose; Glucose; Humans; Kinetics; Lactates; Liver; Oxonic Acid; Rats; Sorbitol; Species Specificity; Urate Oxidase; Uric Acid; Xylitol | 1977 |
The influence of allopurinol in customary and in slow release preparation on different parameters of purine and pyrimidine metabolism.
Topics: Allopurinol; Delayed-Action Preparations; Humans; Orotic Acid; Oxypurinol; Pyrimidines; Time Factors; Uric Acid | 1977 |
The pharmacology of the hypouricemic effect of benzbromarone.
Topics: Aspirin; Benzbromarone; Benzofurans; Blood Proteins; Drug Interactions; Glomerular Filtration Rate; Kidney Tubules; Protein Binding; Pyrazinamide; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1977 |
Panel discussion: hyperuricemia as a risk factor.
Topics: Alcohol Drinking; Allopurinol; Blood Proteins; Body Weight; Coronary Disease; Diabetes Complications; Female; Gout; Humans; Hypertension; Lead Poisoning; Male; Protein Binding; Risk; Uric Acid; Urinary Calculi | 1977 |
Metabolism of intravenous adenine in the pig.
Topics: Adenine; Administration, Oral; Allantoin; Allopurinol; Animals; Hypoxanthines; Injections, Intravenous; Species Specificity; Swine; Uric Acid; Xanthines | 1977 |
Purine excretion in complete adenine phosphoribosyltransferase deficiency: effect of diet and allopurinol therapy.
Topics: Adenine; Adenine Phosphoribosyltransferase; Allopurinol; Child, Preschool; Diet; Humans; Male; Orotic Acid; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid | 1977 |
[Allopurinol and gouty hyperuricemia : apropos of 30 cases treated by a single daily dose].
Topics: Allopurinol; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1977 |
Complete deficiency of adenine phosphoribosyltransferase. Report of a family.
Topics: Adenine; Adenine Phosphoribosyltransferase; Allopurinol; Child; Child, Preschool; Crystallization; Female; Heterozygote; Homozygote; Humans; Infant; Male; Pedigree; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Urinary Calculi | 1977 |
Production of uric acid and existence of xanthine oxidase in rat plasma.
Topics: Adenine Nucleotides; Animals; Erythrocytes; In Vitro Techniques; Male; Rats; Uric Acid; Xanthine Oxidase | 1977 |
Origin of plasma uric acid induced by l-epinephrine.
Topics: Adenosine Triphosphate; Animals; Dogs; Epinephrine; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Rats; Stimulation, Chemical; Uric Acid; Xanthine Oxidase | 1977 |
Hypouricemia in disease: a study of different mechanisms.
Topics: Adenocarcinoma; Adult; Aged; Fanconi Syndrome; Fasting; Female; Humans; Hypoparathyroidism; Kidney; Lung Neoplasms; Male; Middle Aged; Multiple Myeloma; Obesity; Osteomalacia; Uric Acid; Xanthine Oxidase; Xanthines | 1977 |
[Isolated or combined drug therapy of hyperuricemia?].
Topics: Allopurinol; Benzbromarone; Drug Therapy, Combination; Gout; Humans; Uric Acid; Uricosuric Agents | 1977 |
[Comparison of effects of various therapeutic methods of the urinary system in patients with gout. Observations on 195 patients with gout].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Probenecid; Uric Acid; Urinary Tract | 1977 |
Treated and untreated recurrent calcium nephrolithiasis in patients with idiopathic hypercalciuria, hyperuricosuria, or no metabolic disorder.
Topics: Allopurinol; Calcium; Cystoscopy; Female; Hospitalization; Humans; Kidney Calculi; Male; Metabolic Diseases; Oxalates; Recurrence; Trichlormethiazide; Uric Acid | 1977 |
[De novo purine biosynthesis. In vitro measurement in hyperuricemia (author's transl)].
Topics: Adult; Allopurinol; Azaserine; Carbon Radioisotopes; Female; Formates; Gout; Humans; In Vitro Techniques; Kidney Failure, Chronic; Male; Metabolic Diseases; Methods; Middle Aged; Purines; Ribonucleotides; Uric Acid | 1977 |
[The preventive effect of allopurinol on experimental shock (author's transl)].
Topics: Adenine Nucleotides; Allopurinol; Animals; Male; Rabbits; Rats; Shock; Shock, Hemorrhagic; Uric Acid | 1977 |
Uric-acid lithiasis in an infant with cyanotic congenital heart disease.
Topics: Allopurinol; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Kidney Calculi; Male; Purines; Uric Acid | 1977 |
[Enzymopathies as a cause of hyperuricemia].
Topics: Adenine Phosphoribosyltransferase; Carbohydrate Metabolism; Feedback; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Models, Chemical; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Xanthine Oxidase | 1977 |
The treatment of hyperuricemia.
Topics: Allopurinol; Drug Interactions; Drug Therapy, Combination; Humans; Phenylbutazone; Probenecid; Salicylates; Sulfinpyrazone; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1976 |
Allopurinol-induced granulomatous hepatitis.
Topics: Allopurinol; Biopsy; Chemical and Drug Induced Liver Injury; Female; Granuloma; Humans; Liver; Middle Aged; Uric Acid | 1976 |
[Effect of allopurinol on the increase of uric acid and ammonia serum levels after physical load in healthy subjects (author's transl)].
Topics: Adult; Allopurinol; Ammonia; Humans; Male; Physical Exertion; Uric Acid | 1976 |
Uric acid nephropathy.
Topics: Allopurinol; Emergencies; Humans; Kidney Diseases; Leukemia; Mannitol; Peritoneal Dialysis; Renal Dialysis; Uric Acid | 1976 |
[Treatment of hyperuricaemia with a combination of allopurinol and benzbromaron (author's transl)].
Topics: Allopurinol; Benzbromarone; Benzofurans; Drug Combinations; Gout; Humans; Time Factors; Uric Acid | 1976 |
[Changes induced by various drugs (allopurinol, metformin) in various dysmetabolic components of primary hyperuricemia].
Topics: Adolescent; Adult; Aged; Allopurinol; Drug Synergism; Female; Humans; Male; Metformin; Middle Aged; Uric Acid | 1976 |
[Uric acid calculi: therapeutic trends].
Topics: Adult; Aged; Allopurinol; Female; Humans; Male; Middle Aged; Uric Acid; Urinary Calculi | 1976 |
Current therapy of gout and hyperuricemia.
Topics: Allopurinol; Colchicine; Drug Interactions; Gout; Humans; Indomethacin; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1976 |
[Pathogenesis of hyperuricemia and its treatment by means of rigorous fasting (so-called null-diet)].
Topics: Allopurinol; Fasting; Humans; Obesity; Probenecid; Uric Acid | 1976 |
Renal urate transport during variations in urate synthesis in the rat.
Topics: Allantoin; Allopurinol; Animals; Biological Transport; Hypoxanthines; Kidney; Male; Purinones; Rats; Uric Acid | 1976 |
[Uric nephropathy in malignant hemopaties: three cases with conserved diuresis (author's transl)].
Topics: Acute Kidney Injury; Allopurinol; Child; Child, Preschool; Diuresis; Female; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Uremia; Uric Acid | 1976 |
Acute renal failure and gout as presenting features of acute lymphoblastic leukaemia.
Topics: Acute Kidney Injury; Allopurinol; Child, Preschool; Female; Gout; Humans; Leukemia, Lymphoid; Pancytopenia; Prednisolone; Uric Acid; Vincristine | 1976 |
[Use of milurit in hyperuricemia in patients with malignant hemopathies].
Topics: Adolescent; Adult; Aged; Allopurinol; Female; Hodgkin Disease; Humans; Leukemia, Lymphoid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Uric Acid | 1975 |
[Mechanism of action of desferrioxamine].
Topics: Deferoxamine; Depression, Chemical; Hemochromatosis; Humans; Injections, Intramuscular; Iron; Liver; Stimulation, Chemical; Uric Acid; Xanthine Oxidase | 1975 |
Synthesis of uric acid in isolated normothermic perfused mongrel and Dalmatian dog kidneys.
Topics: Allantoin; Allopurinol; Animals; Creatinine; Dogs; Female; Kidney; Male; Perfusion; Uric Acid; Xanthines | 1975 |
Uremic inhibition of purine uptake by rat hepatic slices.
Topics: Allantoin; Animals; Blood Urea Nitrogen; Hypoxanthines; In Vitro Techniques; Liver; Nephrectomy; Purines; Rats; Uremia; Uric Acid; Xanthine Oxidase; Xanthines | 1975 |
The Filipino and gout.
Topics: Adolescent; Adult; Age Factors; Aged; Allopurinol; Cross-Cultural Comparison; Diet; Ethnicity; Female; Gout; Humans; Kidney Diseases; Male; Middle Aged; Philippines; Purines; Recurrence; Sex Factors; United States; Uric Acid | 1975 |
Proceedings: Single daily dose of allopurinol.
Topics: Allopurinol; Gout; Humans; Time Factors; Uric Acid | 1975 |
The influx of uric acid and other purines into everted jejunal sacs of the rat and hamster.
Topics: Allopurinol; Anaerobiosis; Animals; Biological Transport; Cricetinae; Dinitrophenols; Female; Hypoxanthines; In Vitro Techniques; Jejunum; Purines; Rats; Time Factors; Uric Acid; Xanthines | 1975 |
Letter: Xanthinuria as a cause of hypouricaemia in liver disease.
Topics: Humans; Liver Diseases; Male; Purines; Uric Acid; Xanthine Oxidase; Xanthines | 1975 |
[Antiblastic therapy and cytolysis in infantile leukemia].
Topics: Allopurinol; Antineoplastic Agents; Anuria; Bicarbonates; Child; Child, Preschool; Disseminated Intravascular Coagulation; Electrolytes; Humans; Kidney Diseases; Leukemia; Nucleic Acids; Prednisone; Purines; Uric Acid; Vincristine; Xanthines | 1975 |
Gout: diagnosis and management.
Topics: Allopurinol; Anti-Inflammatory Agents; Gout; Humans; Probenecid; Uric Acid | 1975 |
Hemodialysis for acute anuric uric acid nephropathy.
Topics: Abdominal Neoplasms; Acute Kidney Injury; Allopurinol; Child; Cyclophosphamide; Humans; Lymphoma, Non-Hodgkin; Male; Oliguria; Prednisone; Renal Dialysis; Uric Acid; Vincristine | 1975 |
Enzymic micromethod for semiquantatative analysis of oxypurines in specimens of skeletal muscle.
Topics: Humans; Hypoxanthines; Microchemistry; Muscles; Purines; Spectrophotometry; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1975 |
[The effect of allopurinol on hemodynamic, respiratory and biochemical functional values in health persons following oral administration].
Topics: Administration, Oral; Adult; Allopurinol; Blood Circulation; Blood Pressure; Fatty Acids, Nonesterified; Heart; Heart Rate; Hemodynamics; Humans; Lipids; Physical Exertion; Posture; Respiration; Uric Acid; Vascular Resistance | 1975 |
Effects of allopurinol on hepatic adenosine nucleotides in hemorrhagic shock.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Allantoin; Allopurinol; Animals; Dogs; Liver; Lymph; Shock, Hemorrhagic; Uric Acid | 1975 |
[Clinical significance of hyperuricaemia in medically-hospitalized women over 50 years of age (author's transl)].
Topics: Age Factors; Allopurinol; Diuretics; Female; Humans; Hypertension; Lung Diseases; Middle Aged; Uric Acid | 1975 |
[Proceedings: New case of Lesch-Nyhan syndrome. Attempt at treatment using adenine].
Topics: Adenine; Allopurinol; Humans; Infant; Lesch-Nyhan Syndrome; Male; Uric Acid | 1975 |
[Effect of thiopurinol on renal uric acid and oxypurine excretion in man under modified formula diet with a constant purine content].
Topics: Allopurinol; Diet; Gout; Humans; Kidney; Purines; Uric Acid | 1975 |
[Behavior of 5-phosphoribosyl-1-pyrophosphate (PRPP) in erythrocytes, leukocytes and lymphocytes of normal and gouty subjects].
Topics: Adult; Aged; Allopurinol; Erythrocytes; Gout; Humans; Leukocytes; Lymphocytes; Middle Aged; Pentosephosphates; Phosphoribosyl Pyrophosphate; Purines; Uric Acid | 1975 |
[The experimental and clinical studies on the urinary calculi with the special reference to the metabolism of uric acid. Report II: relationship between urinary uric acid excretion and recurrent urinary oxalate containing calculus formation with special r
Topics: Adolescent; Adult; Aged; Allopurinol; Female; Humans; Male; Middle Aged; Oxalates; Recurrence; Uric Acid; Urinary Calculi | 1975 |
[Experience with various fasting-reducing diets with reference to the prevention of hyperuricacidemia].
Topics: Allopurinol; Diet, Reducing; Dietary Carbohydrates; Fasting; Humans; Obesity; Uric Acid | 1976 |
[Uricosuric agents: Should they be used in asymptomatic hyperuricemia?].
Topics: Allopurinol; Humans; Metabolic Diseases; Probenecid; Sulfinpyrazone; Uric Acid | 1976 |
[Which uric acid value is in need of treatment?].
Topics: Allopurinol; Benzbromarone; Citrates; Coronary Disease; Gout; Humans; Hyperlipidemias; Hypertension; Hypoxanthine Phosphoribosyltransferase; Kidney Diseases; Lesch-Nyhan Syndrome; Obesity; Uric Acid | 1976 |
[Conservative treatment of urate urolithiasis in a 4-month-old infant].
Topics: Allopurinol; Humans; Infant; Male; Uric Acid; Urinary Calculi | 1976 |
[Hyperuricemia and hyperuricuria. Their significance for urinary calculi].
Topics: Allopurinol; Humans; Uric Acid; Urinary Calculi | 1976 |
A rapid and simple radioassay for inosinic acid: pyrophosphate phosphoribosyltransferase in the presence of xanthine oxidase and vice versa.
Topics: Allopurinol; Animals; Dialysis; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Monophosphate; Inosine Nucleotides; Intestinal Mucosa; Intestines; Jejunum; Male; Rats; Time Factors; Uric Acid; Xanthine Oxidase | 1976 |
Voltammetric monitoring of brain extracellular levels of serotonin, 5-hydroxyindoleacetic acid and uric acid as assessed by simultaneous microdialysis.
Topics: Allopurinol; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dialysis; Electrochemistry; Electrodes; Extracellular Space; Hydroxyindoleacetic Acid; Male; Pargyline; Rats; Rats, Sprague-Dawley; Serotonin; Uric Acid | 1992 |
Inhibition of xanthine oxidase by uric acid and its influence on superoxide radical production.
Topics: Free Radicals; Kinetics; Oxidation-Reduction; Oxygen; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1992 |
[The management of hyperuricemia associated with drug treatment of hypertension].
Topics: Acidosis; Adrenergic beta-Antagonists; Allopurinol; Antihypertensive Agents; Benzothiadiazines; Diuretics; Humans; Probenecid; Sodium Chloride Symporter Inhibitors; Sulfinpyrazone; Uric Acid | 1992 |
High levels of xanthine oxidoreductase in rat endothelial, epithelial and connective tissue cells. A relation between localization and function?
Topics: Adrenal Cortex; Animals; Connective Tissue; Digestive System; Endothelium; Epithelium; Female; Liver; Male; Muscles; Rats; Rats, Wistar; Respiratory System; Skin; Uric Acid; Urogenital System; Xanthine Dehydrogenase; Xanthine Oxidase | 1992 |
Change of xanthine dehydrogenase and xanthine oxidase activities in rat brain following complete ischaemia.
Topics: Animals; Brain Ischemia; Male; Prosencephalon; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1992 |
Effect of inorganic phosphate on hypoxanthine transport in isolated brain microvessels.
Topics: Alkaline Phosphatase; Animals; Blood Vessels; Blood-Brain Barrier; Brain; Cattle; gamma-Glutamyltransferase; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; In Vitro Techniques; Phosphates; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1992 |
[Long lasting normalization of uric acid after combination therapy with 300 mg allopurinol and 60 mg benzbromarone in patients with gout and hyperuricemia].
Topics: Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Gout; Humans; Male; Uric Acid | 1992 |
[Studies on purine-pyrimidine metabolism (1)--Quantitation of purine-pyrimidine metabolites and allopurinol-oxipurinol in biological fluids].
Topics: Allopurinol; Chromatography, High Pressure Liquid; Humans; Hypoxanthine; Hypoxanthines; Oxypurinol; Purines; Pyrimidines; Uric Acid; Xanthine; Xanthines | 1992 |
[A case of drug-induced litholysis of a uric acid staghorn calculus in the left kidney].
Topics: Adult; Allopurinol; Citrates; Drug Combinations; Drug Therapy, Combination; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Male; Mineral Waters; Pyridoxine; Uric Acid | 1992 |
Reduce serum uric acid levels before withdrawing antihyperuricemic therapy in patients with tophaceous gout.
Topics: Allopurinol; Arthritis, Gouty; Humans; Uric Acid | 1992 |
Urate metabolism during bone marrow transplantation.
Topics: Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Humans; Kidney Diseases; Neoplasms; Uric Acid | 1992 |
Estimating the prevalence of xanthinuria by laboratory screening.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Humans; Infant; Male; Middle Aged; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1992 |
Postnatal development of hepatic xanthine oxidase in baby pigs and turnover of purine catabolites at reduced ambient temperature.
Topics: Animals; Animals, Newborn; Cold Temperature; Hypoxanthine; Hypoxanthines; Kidney Diseases; Kinetics; Liver; Purines; Swine; Swine Diseases; Uric Acid; Xanthine Oxidase | 1992 |
Changes in the xanthine dehydrogenase/xanthine oxidase ratio in the rat kidney subjected to ischemia-reperfusion stress: preventive effect of some flavonoids.
Topics: Animals; Free Radical Scavengers; Ischemia; Kidney; Male; Quercetin; Rats; Rats, Wistar; Reperfusion Injury; Silymarin; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1992 |
[Metabolic disorder of purine nucleotide in patients with chronic renal failure].
Topics: Allopurinol; Humans; Hypoxanthine; Hypoxanthines; Kidney Failure, Chronic; Purine Nucleotides; Renal Dialysis; Uremia; Uric Acid; Xanthine; Xanthines | 1992 |
Antibodies against crystals.
Topics: Allopurinol; Animals; Antibody Formation; Arthritis, Rheumatoid; Crystallography; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Gout; Humans; Immunoglobulin G; Osteoarthritis; Rabbits; Synovial Fluid; Uric Acid | 1992 |
Substrate inhibition of xanthine oxidase and its influence on superoxide radical production.
Topics: Animals; Cattle; Electron Transport; Free Radicals; Horses; Hypoxanthine; Hypoxanthines; Kinetics; Substrate Specificity; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1991 |
Do the copper complexes of histamine, histidine and of two H2-antagonists react with O2-?
Topics: Catalase; Copper; Cytochrome c Group; Histamine; Histamine H2 Antagonists; Histidine; Luminescent Measurements; Mannitol; Nitroblue Tetrazolium; Organometallic Compounds; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1991 |
Neurochemical analysis of focal ischemia in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cysteine; Free Radicals; Glutathione; Guanosine; Hydroxyindoleacetic Acid; Ischemic Attack, Transient; Rats; Rats, Inbred Strains; Serotonin; Tryptophan; Uric Acid; Xanthine Oxidase | 1991 |
Influence of antihyperuricemic therapy on the clinical and radiographic progression of gout.
Topics: Aged; Aged, 80 and over; Allopurinol; Arthritis, Gouty; Humans; Middle Aged; Probenecid; Radiography; Uric Acid; Wrist | 1991 |
Human liver xanthine oxidase: nature and extent of individual variation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Child; Female; Humans; Hydrogen-Ion Concentration; Kidney; Liver; Liver Diseases; Male; Middle Aged; Sex Factors; Specimen Handling; Uric Acid; Xanthine Oxidase | 1991 |
[Characteristics of uric acid metabolism and the activity of various enzymes in the families of patients with interstitial nephritis].
Topics: Adult; Alkaline Phosphatase; Child; Circadian Rhythm; Creatine Kinase; Humans; L-Lactate Dehydrogenase; Nephritis, Interstitial; Uric Acid; Xanthine Oxidase | 1991 |
A novel xanthine dehydrogenase inhibitor (BOF-4272).
Topics: Allopurinol; Animals; Humans; Hypoxanthine; Hypoxanthines; Intestine, Small; Kinetics; Liver; Lung; Male; Mice; Mice, Inbred ICR; Reference Values; Species Specificity; Triazines; Urate Oxidase; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthines | 1991 |
Changes caused by ethanol intake on metabolism of hypouricemic agents (combination of allopurinol and benzbromarone).
Topics: Adult; Alcohol Drinking; Allopurinol; Benzbromarone; Ethanol; Humans; Male; Middle Aged; Time Factors; Uric Acid | 1991 |
Significance of hypouricemia.
Topics: Creatinine; Female; Glomerular Filtration Rate; Humans; Male; Sex Characteristics; Uric Acid; Xanthine Oxidase | 1991 |
Role of oxygen radicals in tourniquet-related ischemia-reperfusion injury of human patients.
Topics: Adult; Arm; Free Radicals; Histamine; Humans; Oxygen; Reperfusion Injury; Tourniquets; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1991 |
Uric acid content of Drosophila decreases with aging.
Topics: Aging; Animals; Drosophila melanogaster; Male; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1991 |
Cellular damage and early metabolic function of transplanted livers stored in Eurocollins or University of Wisconsin solution.
Topics: Adenosine; Adult; Allopurinol; Amino Acids; Bile Acids and Salts; Female; Glutathione; Humans; Hypertonic Solutions; Insulin; Liver; Liver Transplantation; Male; Middle Aged; Organ Preservation; Organ Preservation Solutions; Raffinose; Solutions; Uric Acid | 1991 |
[Consecutive observation of the plasma MDA, XO and UA levels and erythrocyte SOD in 10 cases of cardiopulmonary bypass].
Topics: Cardiopulmonary Bypass; Erythrocytes; Female; Free Radicals; Humans; Intraoperative Period; Male; Malondialdehyde; Superoxide Dismutase; Time Factors; Uric Acid; Xanthine Oxidase | 1991 |
[A study on treatment of hyperuricemia--effects and kinetics of allopurinol and oxipurinol].
Topics: Adult; Allopurinol; Humans; Hypoxanthine; Hypoxanthines; Male; Oxypurinol; Reference Values; Uric Acid; Xanthine; Xanthines | 1991 |
Transcapillar metabolism of lipid- and watersoluble antioxidants as marker of chronical stress in coming population of circumpolar regions.
Topics: Adaptation, Physiological; Arctic Regions; Capillary Permeability; Cold Temperature; Humans; Malondialdehyde; Oxygen; Stress, Physiological; Sulfhydryl Compounds; Uric Acid; Vitamin E; Xanthine Oxidase | 1991 |
Hyperuricemia induced by the uricosuric drug probenecid in rats.
Topics: Allopurinol; Animals; Hepatectomy; Hypoxanthines; Inulin; Kidney Function Tests; Male; Oxonic Acid; Probenecid; Pyrazinamide; Rats; Rats, Inbred Strains; Uric Acid; Xanthines | 1991 |
Lung injury and complement activation: role of neutrophils and xanthine oxidase.
Topics: Animals; Complement Activation; Elapid Venoms; Free Radicals; Histamine; Hydroxides; Lung; Lung Injury; Male; Neutrophils; Rats; Uric Acid; Xanthine Oxidase | 1991 |
Clinical significance of hypouricemia in hospitalized patients.
Topics: Adolescent; Adult; Aged; Allopurinol; Anti-Bacterial Agents; Antineoplastic Agents; Child; Female; Glucocorticoids; Hospitalization; Humans; Incidence; Japan; Liver Diseases; Male; Middle Aged; Neoplasms; Retrospective Studies; Transfusion Reaction; Uric Acid | 1991 |
[The total absence of xanthine oxidase activity. Apropos 2 cases of the nonfamilial incidence of xanthinuria].
Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Female; Humans; Hypoxanthines; Male; Middle Aged; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Oxidase; Xanthines | 1991 |
1-Methylxanthine derived from theophylline as an in vivo biochemical probe of allopurinol effect.
Topics: Adult; Allopurinol; Biomarkers; Female; Humans; Male; Oxypurinol; Theophylline; Uric Acid; Xanthines | 1991 |
Nephrotoxicity of allopurinol is enhanced in experimental hypertension.
Topics: Allopurinol; Anemia; Animals; Drinking; Hypertension; Kidney; Male; Osmolar Concentration; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Uric Acid | 1991 |
Xanthine oxidase is not a major source of free radicals in focal cerebral ischemia.
Topics: Allopurinol; Animals; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Free Radicals; Male; Oxygen; Rats; Rats, Inbred Strains; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1991 |
Urate and calcium stones--picking up a drop of mercury with one's fingers?
Topics: Allopurinol; Animals; Calcium Oxalate; Glycosaminoglycans; Gout; Humans; Kidney Calculi; Uric Acid | 1991 |
Does xanthine oxidase cause damage during myocardial ischemia?
Topics: Aging; Animals; Cattle; Coronary Disease; Guinea Pigs; Humans; In Vitro Techniques; Mice; Myocardium; Rabbits; Rats; Species Specificity; Swine; Uric Acid; Xanthine Oxidase | 1991 |
Oleic acid-induced injuries in the guinea-pig. Effects of allopurinol on cell dynamics, erythrocyte-catalase and uric acid plasma levels.
Topics: Allopurinol; Animals; Blood Cell Count; Catalase; Erythrocytes; Guinea Pigs; Leukocyte Count; Lung Diseases; Male; Microcirculation; Neutrophils; Oleic Acid; Oleic Acids; Platelet Count; Thrombocytopenia; Uric Acid | 1991 |
Pharmacological evidence, using in vivo dialysis, that substances additional to ascorbic acid, uric acid and homovanillic acid contribute to the voltammetric signals obtained in unrestrained rats from chronically implanted carbon paste electrodes.
Topics: Allopurinol; Animals; Ascorbic Acid; Carbon; Chromatography, High Pressure Liquid; Dialysis; Electrodes, Implanted; Electrophysiology; Extracellular Space; Homovanillic Acid; Male; Pargyline; Rats; Rats, Inbred Strains; Uric Acid | 1991 |
Uric acid synthesis by avian exocrine pancreas.
Topics: Allopurinol; Animals; Cell Count; Chickens; Kinetics; Male; Pancreas; Proteins; Purines; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthines | 1991 |
Molybdenum in the premature infant.
Topics: Creatinine; Humans; Infant Food; Infant, Newborn; Infant, Premature; Milk, Human; Molybdenum; Uric Acid; Xanthine Oxidase | 1991 |
Inhibition of transition metal ion-catalysed ascorbate oxidation and lipid peroxidation by allopurinol and oxypurinol.
Topics: Allopurinol; Ascorbic Acid; Butylated Hydroxytoluene; Copper; Edetic Acid; Erythrocyte Membrane; Humans; Iron; Lipid Peroxidation; Membrane Lipids; Oxidation-Reduction; Oxypurinol; Pyrimidines; Uric Acid | 1990 |
Allopurinol protects pancreatic beta cells from the cytotoxic effect of streptozotocin: in vitro study.
Topics: Adenosine Triphosphate; Allopurinol; Animals; Chromatography, High Pressure Liquid; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; NAD; Rats; Rats, Inbred Strains; Streptozocin; Uric Acid; Xanthine Oxidase | 1990 |
Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products.
Topics: Allantoin; Ceruloplasmin; Chromatography, High Pressure Liquid; Edetic Acid; Ferric Compounds; Hemoglobins; Hydantoins; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Hypochlorous Acid; Hypoxanthine; Hypoxanthines; Imidazoles; Kinetics; Molecular Structure; Myoglobin; Oxidation-Reduction; Oxonic Acid; Uric Acid; Xanthine Oxidase | 1990 |
Renal purine efflux and xanthine oxidase activity during experimental nephrosis in rats: difference between puromycin aminonucleoside and adriamycin nephrosis.
Topics: Allantoin; Animals; Doxorubicin; Hypoxanthines; Kidney; Male; Nephrosis; Proteinuria; Purines; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Time Factors; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthines | 1990 |
Luminol chemiluminescence using xanthine and hypoxanthine as xanthine oxidase substrates.
Topics: Animals; Cattle; Dithionite; Hypoxanthine; Hypoxanthines; Kinetics; Luminescent Measurements; Luminol; Milk; Pyridazines; Spectrophotometry, Ultraviolet; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1990 |
[Is xanthine oxidase a universal source of superoxide radicals in ischemic and reperfusion lesions?].
Topics: Animals; Chromatography; Free Radicals; Hypoxanthine; Hypoxanthines; Ischemia; Liver; Rats; Reperfusion; Superoxides; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthines | 1990 |
Clinical quiz. Elevated urinary uric acid excretion (UUAE).
Topics: Allopurinol; Creatinine; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Kidney Calculi; Male; Syndrome; Ultrasonography; Uric Acid | 1990 |
Electron cytochemical studies of Cryptococcus neoformans grown on uric acid and related sources of nitrogen.
Topics: Alkaline Phosphatase; Cryptococcus neoformans; Culture Media; Cytoplasmic Granules; Microbodies; Microscopy, Electron; Molybdenum; Phosphorus; Urate Oxidase; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1990 |
[Clinical studies on hyperuricemia and gout after transplantation].
Topics: Adult; Allopurinol; Analgesics; Benzbromarone; Female; Gout; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Uric Acid | 1990 |
Familial hyperuricemia and renal insufficiency.
Topics: Adolescent; Adult; Allopurinol; Gout; Humans; Kidney Diseases; Kidney Failure, Chronic; Male; Pedigree; Uric Acid | 1990 |
Cyclosporine-induced hyperuricemia and gout.
Topics: Allopurinol; Azathioprine; Cyclosporins; Drug Interactions; Gout; Humans; Transplantation, Homologous; Uric Acid | 1990 |
Adenosine, inosine, and hypoxanthine/xanthine measured in tissue and plasma by a luminescence method.
Topics: Adenosine; Adenosine Deaminase; Animals; Dogs; Humans; Hypoxanthine; Hypoxanthines; Inosine; Luminescent Measurements; Luminol; Pyridazines; Rabbits; Rats; Solutions; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1990 |
Improved survival in intestinal ischemia by allopurinol not related to xanthine-oxidase inhibition.
Topics: Allopurinol; Animals; Chromatography, Liquid; Hypoxanthine; Hypoxanthines; Intestines; Ischemia; Oxypurinol; Rats; Rats, Inbred Strains; Uric Acid; Xanthine Oxidase | 1990 |
[Aplastic anemia probably induced by allopurinol in a patient with renal insufficiency].
Topics: Allopurinol; Anemia, Aplastic; Female; Humans; Kidney Failure, Chronic; Middle Aged; Uric Acid | 1990 |
Excretion of purine derivatives by ruminants: endogenous excretion, differences between cattle and sheep.
Topics: Allantoin; Animals; Cattle; Hypoxanthine; Hypoxanthines; Male; Purines; Sheep; Swine; Urate Oxidase; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1990 |
Hyponatremia and hypouricemia: differentiation from SIADH.
Topics: Adult; Diagnosis, Differential; Humans; Hyponatremia; Inappropriate ADH Syndrome; Kidney; Male; Middle Aged; Sodium; Uric Acid; Vasopressins; Xanthine Oxidase | 1990 |
Substituted cyclic imides as potential anti-gout agents.
Topics: Allopurinol; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Gout; Gout Suppressants; Imides; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Phthalimides; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1990 |
Decreased xanthine oxidase activities and increased urinary oxypurines in heterozygotes for hereditary xanthinuria.
Topics: Adult; Creatinine; Female; Heterozygote; Humans; Hypoxanthines; Kinetics; Male; Pedigree; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Xanthine Oxidase; Xanthines | 1990 |
Allopurinol influences aminophenazone elimination.
Topics: Allopurinol; Aminopyrine; Breath Tests; Drug Interactions; Half-Life; Humans; Injections, Intravenous; Male; Middle Aged; Uric Acid | 1990 |
Relationship of plasma and urine composition to recurrence of calcium urinary stones in patients on drug therapy.
Topics: Adult; Allopurinol; Calcium; Chlorothiazide; Creatinine; Drug Combinations; Electrolytes; Humans; Middle Aged; Recurrence; Uric Acid; Urinary Calculi | 1990 |
Clinical profile, therapeutic approach and outcome of gouty arthritis in northern India.
Topics: Adult; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Evaluation Studies as Topic; Humans; India; Male; Middle Aged; Patient Education as Topic; Sulfinpyrazone; Uric Acid | 1990 |
Xanthine oxidoreductase activity in perfused hearts of various species, including humans.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Guinea Pigs; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Ketone Oxidoreductases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Myocardium; Perfusion; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Swine; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthines | 1990 |
Electrochemical detection in vivo: indoleamines or uric acid?
Topics: Allopurinol; Animals; Brain; Electrochemistry; Electrodes; False Positive Reactions; Hydroxyindoleacetic Acid; Rats; Serotonin; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1986 |
In vivo electrochemical detection of 5-hydroxyindoles in the dorsal horn of the spinal cord: the contribution of uric acid to the voltammograms.
Topics: Allopurinol; Animals; Electrochemistry; Fenclonine; Hydroxyindoleacetic Acid; Male; Microelectrodes; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord; Uric Acid | 1987 |
Oxygen metabolites modulate prostaglandin E2 production by isolated gastric mucosal cells.
Topics: Animals; Bradykinin; Calcimycin; Dinoprostone; Dogs; Dose-Response Relationship, Drug; Gastric Mucosa; Hydrogen Peroxide; In Vitro Techniques; Oxygen; Superoxide Dismutase; Uric Acid; Xanthine Oxidase | 1989 |
Oxidant inhibition of epithelial active sodium transport.
Topics: Animals; Biological Transport, Active; Bufo marinus; Epithelium; Hydrogen Peroxide; In Vitro Techniques; Kinetics; Skin; Sodium; Uric Acid; Xanthine Oxidase | 1989 |
Effect of probenecid on oxypurines in plasma.
Topics: Adenosine Deaminase; Adult; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Male; Probenecid; Purine-Nucleoside Phosphorylase; Uric Acid; Xanthine Oxidase; Xanthines | 1989 |
Inactivation of alpha 1-antiproteinase by hydroxyl radicals. The effect of uric acid.
Topics: alpha 1-Antitrypsin; Ascorbic Acid; Blood Proteins; Chemical Phenomena; Chemistry; Edetic Acid; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxides; Hydroxyl Radical; Hypoxanthine; Hypoxanthines; Indomethacin; Iron; Nitrous Oxide; Pancreatic Elastase; Piroxicam; Protease Inhibitors; Pulse Radiolysis; Superoxides; Uric Acid; Xanthine Oxidase | 1989 |
Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generation.
Topics: Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxides; Hydroxyl Radical; Kinetics; Spin Labels; Uric Acid; Xanthine Oxidase | 1989 |
In vitro spinal cord conduction block during exposure to a xanthine oxidase/hypoxanthine system: noninvolvement of superoxide and hydrogen peroxide.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Axons; Hydrogen Peroxide; Hypoxanthines; Lipid Peroxidation; Male; Nerve Block; Neural Conduction; Rats; Rats, Inbred Strains; Spinal Cord; Superoxides; Time Factors; Uric Acid; Xanthine Oxidase | 1989 |
An assay for superoxide dismutase activity in mammalian tissue homogenates.
Topics: Adenocarcinoma; Animals; Colorimetry; Cytochrome c Group; Female; Iron; Liver; Mammary Glands, Animal; Mice; Mitochondria, Liver; Nitroblue Tetrazolium; Pregnancy; Rats; Rats, Inbred Strains; Superoxide Dismutase; Uric Acid; Vitamin K; Xanthine Oxidase | 1989 |
Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver.
Topics: Animals; Female; Hypoxanthine; Hypoxanthines; L-Lactate Dehydrogenase; Liver Circulation; Malondialdehyde; Rats; Rats, Inbred Strains; Reperfusion Injury; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1989 |
Hyperoxia and xanthine dehydrogenase/oxidase activities in rat lung and heart.
Topics: Animals; Free Radicals; Hydrogen Peroxide; In Vitro Techniques; Ketone Oxidoreductases; Lung; Male; Myocardium; Organ Size; Oxygen; Rats; Rats, Inbred Strains; Superoxides; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1989 |
Uric acid as radical scavenger and antioxidant in the heart.
Topics: Acetylcholine; Adenosine; Allopurinol; Animals; Antioxidants; Coronary Vessels; Dimethyl Sulfoxide; Free Radicals; Guinea Pigs; Heart; Hydroxides; Hydroxyl Radical; Male; Myocardium; Oxidation-Reduction; Superoxides; Uric Acid; Xanthine Oxidase | 1989 |
Inhibition of xanthine oxidase by 4-hydroxy-6-mercaptopyrazolo[3,4-d]pyrimidine.
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Free Radicals; Humans; Hydrogen Peroxide; Hypoxanthine; Hypoxanthines; Kinetics; Mice; Oxypurinol; Pyrimidines; Superoxides; Uric Acid; Xanthine Oxidase | 1989 |
Activity and effect of purine metabolizing enzymes in the digestive tract.
Topics: Adenosine Deaminase; Administration, Oral; Animals; Chickens; Digestive System; Humans; Liposomes; Nucleoside Deaminases; Nucleotidases; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purines; Uric Acid; Xanthine Oxidase | 1989 |
Roles of histamine, complement and xanthine oxidase in thermal injury of skin.
Topics: Animals; Burns; Cimetidine; Complement Inactivator Proteins; Complement System Proteins; Cromolyn Sodium; Edema; Elapid Venoms; Endothelium, Vascular; Histamine; Histamine H1 Antagonists; Hydroxides; Hydroxyl Radical; Kinetics; Male; Radioimmunoassay; Rats; Skin; Superoxides; Uric Acid; Xanthine Oxidase | 1989 |
Lever pressing for food reward and in vivo voltammetry: evidence for increases in extracellular homovanillic acid, the dopamine metabolite, and uric acid in the rat caudate nucleus.
Topics: Allopurinol; Animals; Caudate Nucleus; Dopamine; Electrochemistry; Feeding Behavior; Homovanillic Acid; Male; Rats; Rats, Inbred Strains; Reward; Uric Acid | 1989 |
The metabolic relation between hypoxanthine and uric acid in man following maximal short-distance running.
Topics: Adult; Humans; Hypoxanthine; Hypoxanthines; Male; Oxygen Consumption; Running; Uric Acid; Xanthine Oxidase | 1989 |
Purine and oxypurine production in mitochondria of ischemic and reperfused myocardium.
Topics: Adenine Nucleotides; Adenosine; Allopurinol; Animals; Hypoxanthine; Hypoxanthines; Male; Malondialdehyde; Mitochondria, Heart; Myocardial Reperfusion Injury; Purines; Rats; Rats, Inbred Strains; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthines | 1989 |
Hypoxanthine and xanthine transport through the blood-brain barrier in hypoxanthine phosphoribosyltransferase (HPRT) deficiency.
Topics: Allopurinol; Biological Transport; Blood-Brain Barrier; Humans; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine; Uric Acid; Xanthines | 1989 |
Should dietary restrictions always be prescribed in the treatment of gout?
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Diet; Female; Gout; Humans; Male; Middle Aged; Prevalence; Uric Acid | 1989 |
Intermittent control of hyperuricaemia in the treatment of gout.
Topics: Allopurinol; Arthritis, Gouty; Gout; Humans; Middle Aged; Uric Acid | 1989 |
The allopurinol hypersensitivity syndrome: its relation to plasma oxypurinol levels.
Topics: Aged; Aged, 80 and over; Allopurinol; Drug Hypersensitivity; Humans; Male; Metabolism, Inborn Errors; Oxypurinol; Pyrimidines; Uric Acid | 1989 |
[Clearance of oxypurines in normal subjects and in gout patients subjected to a purine-free diet. Effects of allopurinol].
Topics: Adult; Allopurinol; Creatinine; Diet; Gout; Humans; Hypoxanthine; Hypoxanthines; Middle Aged; Uric Acid; Xanthine; Xanthines | 1989 |
Renal oxypurine deposition in Lesch-Nyhan syndrome: sonographic evaluation.
Topics: Allopurinol; Child; Humans; Hypoxanthine; Hypoxanthines; Kidney Calculi; Lesch-Nyhan Syndrome; Male; Ultrasonography; Uric Acid; Xanthine; Xanthines | 1989 |
Critical issues in chemotherapy with tiazofurin.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Down-Regulation; Drug Interactions; Female; Genes, ras; Guanine; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Liver Neoplasms, Experimental; Male; Middle Aged; Ribavirin; Ribonucleosides; Tretinoin; Tumor Cells, Cultured; Uric Acid | 1989 |
[Differential indications for uricosuric drugs and allopurinol].
Topics: Allopurinol; Combined Modality Therapy; Dietary Proteins; Gout; Humans; Uric Acid; Uricosuric Agents | 1989 |
[Adverse effects of drug metaphylaxis of urolithiasis].
Topics: Allopurinol; Humans; Hydrochlorothiazide; Uric Acid; Urinary Calculi | 1989 |
Induction of profound hypouricemia by a non-sedating thiobarbiturate.
Topics: Antineoplastic Agents; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Serum Albumin; Thiobarbiturates; Ultrafiltration; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1989 |
Measurement of urinary caffeine metabolites reflecting the "in vivo" xanthine oxidase activity in premature infants with RDS and in hypoxic states of children.
Topics: Biomarkers; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Respiratory Distress Syndrome, Newborn; Uric Acid; Xanthine Oxidase | 1989 |
[Hereditary xanthinuria. A clinical case report].
Topics: Aged; Biopsy, Needle; Heart Failure; Humans; Hypoxanthines; Liver; Liver Diseases, Alcoholic; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Oxidase; Xanthines | 1989 |
Xanthine oxidase activity: simultaneous HPLC evaluation of the "D" and "O" forms.
Topics: Animals; Chromatography, High Pressure Liquid; Ketone Oxidoreductases; Kidney; Kinetics; Myocardium; NAD; Rats; Rats, Inbred Strains; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1989 |
Prevention of urate nephropathy in the tumour lysis syndrome.
Topics: Adolescent; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Daunorubicin; Diuresis; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tumor Lysis Syndrome; Uric Acid; Vincristine | 1989 |
[Dietary change aids in hyperuricemia. Kidney damage--denial of alcohol--allopurinol].
Topics: Allopurinol; Diet Therapy; Female; Food, Formulated; Humans; Kidney Diseases; Male; Temperance; Uric Acid | 1989 |
[Changes in xanthine oxidase activity in patients with circulatory failure].
Topics: Female; Heart Failure; Humans; Male; Rheumatic Heart Disease; Uric Acid; Xanthine Oxidase | 1989 |
Cerebral uric acid, xanthine, and hypoxanthine after ischemia: the effect of allopurinol.
Topics: Allopurinol; Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hypoxanthine; Hypoxanthines; Ischemic Attack, Transient; Male; Rats; Rats, Inbred Strains; Uric Acid; Xanthine; Xanthines | 1989 |
[Xanthine oxidoreductase activity in rat brain tissue: the changes after decapitation].
Topics: Allopurinol; Animals; Brain; Brain Ischemia; In Vitro Techniques; Ketone Oxidoreductases; Male; Rats; Rats, Inbred Strains; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1989 |
Allopurinol inhibits uric acid accumulation in the rat brain following focal cerebral ischemia.
Topics: Allopurinol; Animals; Brain; Brain Ischemia; Male; Rats; Rats, Inbred Strains; Uric Acid | 1989 |
Hematuria due to hypercalciuria and hyperuricosuria in adult patients.
Topics: Adolescent; Adult; Allopurinol; Calcium; Female; Follow-Up Studies; Hematuria; Humans; Hydrochlorothiazide; Male; Middle Aged; Prospective Studies; Uric Acid | 1989 |
A survey of current prescribing practices of anti-inflammatory and urate-lowering drugs in gouty arthritis in New South Wales and Queensland.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Drug Utilization; Family Practice; Humans; New South Wales; Queensland; Rheumatology; Uric Acid | 1989 |
[Hypo-uricemia].
Topics: Allopurinol; Humans; Nucleotides; Probenecid; Urate Oxidase; Uric Acid | 1989 |
[Fatal toxic epidermolysis following administration of allopurinol].
Topics: Aged; Allopurinol; Epidermolysis Bullosa; Gastrointestinal Hemorrhage; Humans; Kidney Failure, Chronic; Male; Uric Acid; Vasculitis | 1989 |
Alkaline phosphatase inactivation by mixed function oxidation systems.
Topics: Alkaline Phosphatase; Antioxidants; Ascorbic Acid; Catalase; Cations, Divalent; Copper; Ferric Compounds; Ferrous Compounds; Free Radicals; Glutathione; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Kinetics; Mercaptoethanol; Metals; Mixed Function Oxygenases; Oxidation-Reduction; Peroxidase; Superoxide Dismutase; Thiourea; Uric Acid; Vitamin E; Xanthine Oxidase | 1987 |
Copper(II)ethylenediaminetetraacetate does disproportionate superoxide.
Topics: Copper; Edetic Acid; Hydrogen-Ion Concentration; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine Oxidase | 1988 |
How relevant is the reoxidation of ferrocytochrome c by hydrogen peroxide when determining superoxide anion production?
Topics: Anions; Chromatography, Gel; Cytochrome c Group; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Kinetics; Oxidation-Reduction; Photolysis; Superoxides; Ultraviolet Rays; Uric Acid; Xanthine Oxidase | 1988 |
Role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system.
Topics: Animals; Azides; Catalase; Cell Line; Cell Survival; Culture Media; Epithelial Cells; Epithelium; Free Radicals; Hydrogen Peroxide; Oxygen; Sodium Azide; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1988 |
Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid.
Topics: Cyclohexanones; Cytochrome c Group; Humans; Hydrogen Peroxide; Hypochlorous Acid; Peroxidase; Spectrophotometry; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine Oxidase | 1988 |
H2O2 formation during nucleotide degradation in the hypoxic rat liver: a quantitative approach.
Topics: Animals; Cytosol; Glutathione; Hydrogen Peroxide; Hypoxia; Liver; Microbodies; NAD; Nucleotides; Oxygen Consumption; Rats; Rats, Inbred Strains; Superoxides; Uric Acid; Xanthine Oxidase | 1986 |
Action of uric acid, allopurinol and oxypurinol on the myeloperoxidase-derived oxidant hypochlorous acid.
Topics: Allopurinol; Free Radicals; Hypochlorous Acid; Oxidation-Reduction; Oxypurinol; Pancreatic Elastase; Peroxidase; Pyrimidines; Uric Acid | 1987 |
Plasma uric acid levels in ethanol-fed turkey poults treated with allopurinol.
Topics: Allopurinol; Animals; Cardiomyopathy, Alcoholic; Ethanol; Male; Poultry Diseases; Turkeys; Uric Acid | 1987 |
[Effect of tranquilizers of the 1,4-benzodiazepine series on the xanthine oxidase activity of the rat brain].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Diazepam; Dose-Response Relationship, Drug; Male; Nitrazepam; Oxidation-Reduction; Rats; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1988 |
Non-responsiveness to allopurinol in renal hypouricaemia.
Topics: Allopurinol; Female; Humans; Kidney Diseases; Kidney Tubules; Male; Metabolic Clearance Rate; Middle Aged; Oxypurinol; Uric Acid | 1989 |
[Allopurinol-induced kidney failure with hepatitis and squamous dermatitis in pre-existing kidney insufficiency].
Topics: Acute Kidney Injury; Aged; Allopurinol; Chemical and Drug Induced Liver Injury; Dermatitis, Exfoliative; Female; Humans; Kidney Failure, Chronic; Uric Acid | 1987 |
Antioxidant activity of some antiproteases.
Topics: Antioxidants; Cytochrome c Group; Hydrogen Peroxide; Oxidation-Reduction; Protease Inhibitors; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1985 |
Enzymic determination of inorganic phosphates, organic phosphates and phosphate-liberating enzymes by use of nucleoside phosphorylase-xanthine oxidase (dehydrogenase)-coupled reactions.
Topics: 5'-Nucleotidase; Adenosine Monophosphate; Diphosphates; Glucose-6-Phosphatase; Inorganic Pyrophosphatase; Kinetics; Nucleotidases; Organophosphorus Compounds; Pentosyltransferases; Phosphates; Purine-Nucleoside Phosphorylase; Pyrophosphatases; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1985 |
Use of the discriminant index in dynamic treatment to reduce recurrence of calcium oxalate kidney stones.
Topics: Adult; Aged; Allopurinol; Calcium; Calcium Oxalate; Chlorothiazide; Diphosphates; Female; Follow-Up Studies; Humans; Kidney Calculi; Male; Middle Aged; Recurrence; Uric Acid | 1985 |
[Dissolution of uric acid calculi].
Topics: Adult; Aged; Allopurinol; Bicarbonates; Child; Drinking; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Male; Middle Aged; Sodium; Sodium Bicarbonate; Uric Acid; Urinary Bladder Calculi | 1985 |
Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation.
Topics: Ferritins; Free Radicals; Oxygen; Superoxide Dismutase; Superoxides; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1986 |
Gout and hyperuricemia: diagnosis and management.
Topics: Adult; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Colchicine; Female; Gout; Humans; Kidney Diseases; Male; Middle Aged; Sex Factors; Uric Acid | 1986 |
Intractable gouty arthritis.
Topics: Allopurinol; Arthritis; Colchicine; Duodenal Ulcer; Gout; Humans; Hypertension; Indomethacin; Male; Middle Aged; Nephrocalcinosis; Synovial Fluid; Uric Acid | 1987 |
Asymptomatic hyperuricemia and allopurinol induced toxic epidermal necrolysis.
Topics: Aged; Allopurinol; Drug Eruptions; Humans; Male; Stevens-Johnson Syndrome; Uremia; Uric Acid | 1985 |
Molybdenum co-factor deficiency: an easily missed inborn error of metabolism.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Chromosome Aberrations; Chromosome Disorders; Coenzymes; Female; Genes, Recessive; Humans; Infant; Intellectual Disability; Metalloproteins; Molybdenum Cofactors; Oxidoreductases Acting on Sulfur Group Donors; Pteridines; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Oxidase | 1988 |
Allopurinol hypersensitivity in a patient with coexistent systemic lupus erythematosus and tophaceous gout.
Topics: Adult; Allopurinol; Arthrography; Drug Hypersensitivity; Fingers; Gout; Humans; Klinefelter Syndrome; Lupus Erythematosus, Systemic; Male; Uric Acid | 1988 |
[Dose response relations of allopurinol].
Topics: Allopurinol; Dose-Response Relationship, Drug; Gout; Humans; Uric Acid | 1988 |
Inhibition of purine catabolism by benzbromarone in isolated rat liver cells. Comparison with allopurinol and probenecid.
Topics: Allopurinol; Animals; Benzbromarone; Benzofurans; In Vitro Techniques; Liver; Male; Probenecid; Purines; Rats; Rats, Inbred Strains; Uric Acid | 1988 |
Xanthine and uric acid levels in rat brain following focal ischemia.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Ischemic Attack, Transient; Kinetics; Male; Rats; Rats, Inbred Strains; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1988 |
[Medications against gout].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Gout; Humans; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1988 |
Allopurinol dosage selection: relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Oxypurinol; Pyrimidines; Uric Acid; Xanthine; Xanthines | 1988 |
A kinetic study of hypoxanthine oxidation by milk xanthine oxidase.
Topics: Animals; Hypoxanthine; Hypoxanthines; Kinetics; Milk; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1988 |
Impact of allopurinol treatment on the prevention of hyperuricosuric calcium oxalate lithiasis.
Topics: Allopurinol; Calcium Oxalate; Female; Follow-Up Studies; Humans; Male; Middle Aged; Recurrence; Retrospective Studies; Time Factors; Uric Acid; Urinary Calculi | 1988 |
Interaction between allopurinol and pyrazinamide.
Topics: Adult; Allopurinol; Drug Interactions; Drug Therapy, Combination; Humans; Joint Diseases; Male; Pain; Pyrazinamide; Tuberculosis, Pulmonary; Uric Acid | 1988 |
[Intravital dissolution of uric acid calculi with citrolyt and allopurinol].
Topics: Adult; Alkalies; Allopurinol; Female; Humans; Kidney Calculi; Middle Aged; Uric Acid | 1988 |
Increase of urate formation by stimulation of sympathetic hepatic nerves, circulating noradrenaline and glucagon in the perfused rat liver.
Topics: Allopurinol; Animals; Glucagon; Glucose; Insulin; Lactates; Lactic Acid; Liver; Male; Nitroprusside; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Uric Acid | 1987 |
Xanthine oxidase inhibition attenuates ischemic-reperfusion lung injury.
Topics: Animals; Iodine Radioisotopes; Ischemia; Lung; Microscopy, Electron; Oxamic Acid; Regional Blood Flow; Serum Albumin, Bovine; Uric Acid; Xanthine Oxidase | 1988 |
Allopurinol kinetics after massive overdosage.
Topics: Adolescent; Allopurinol; Female; Half-Life; Humans; Oxypurinol; Uric Acid; Xanthine; Xanthines | 1988 |
Effect of isoproterenol on renal uric acid excretion in rats.
Topics: Allopurinol; Animals; Blood Pressure; Isoproterenol; Male; Oxonic Acid; Phenylephrine; Rats; Rats, Inbred Strains; Uric Acid | 1987 |
Purine excretion during tumor lysis in children with acute lymphocytic leukemia receiving allopurinol: relationship to acute renal failure.
Topics: Acute Kidney Injury; Allopurinol; Child; Glomerular Filtration Rate; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Lymphoid; Spectrophotometry, Infrared; Uric Acid; Xanthine; Xanthines | 1986 |
Xanthine lithiasis, nephrocalcinosis, and renal failure in a leukemia patient treated with allopurinol.
Topics: Acute Kidney Injury; Allopurinol; Child; Humans; Kidney Calculi; Leukemia, Lymphoid; Male; Phosphorus; Uric Acid; Xanthine; Xanthines | 1987 |
Mechanism of urate production by guinea-pig ileum.
Topics: Adenosine Deaminase Inhibitors; Animals; Biological Transport; Coformycin; Female; Guanosine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Organ Size; Oxypurinol; Pentostatin; Purines; Thionucleosides; Uric Acid; Xanthine Oxidase | 1986 |
Gout and hyperuricaemia.
Topics: Allopurinol; Colchicine; Cross-Sectional Studies; Family Practice; Female; Gout; Humans; Indomethacin; Male; Middle Aged; Uric Acid; Victoria | 1987 |
[Effect of an allopurinol/benzbromaron preparation on the composition of urine in a circadian course].
Topics: Adult; Allopurinol; Benzbromarone; Benzofurans; Calcium Oxalate; Circadian Rhythm; Drug Therapy, Combination; Female; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Male; Uric Acid | 1987 |
Pharmacologic treatment of uric acid calculi.
Topics: Allopurinol; Citrates; Citric Acid; Dietary Proteins; Fluid Therapy; Humans; Methionine; Uric Acid; Urinary Calculi | 1987 |
Sustained reductions in oxipurinol renal clearance during a restricted diet.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Allopurinol; Dietary Proteins; Humans; Hydroxybutyrates; Kidney; Kinetics; Male; Metabolic Clearance Rate; Oxypurinol; Pyrimidines; Time Factors; Uric Acid | 1987 |
[Effect of decrease in hyperuricemia levels on joint, kidney and other symptoms in patients with gout].
Topics: Adult; Aged; Allopurinol; Arthritis; Colchicine; Coronary Disease; Gout; Humans; Hypertension; Middle Aged; Probenecid; Uric Acid; Urinary Calculi | 1987 |
Comparison of the urate lowering effects of allopurinol and diflunisal.
Topics: Allopurinol; Diflunisal; Gout; Humans; Osmolar Concentration; Salicylates; Uric Acid; Xanthine; Xanthines | 1987 |
Hyperuricemia and uric acid nephropathy.
Topics: Aged; Allopurinol; Female; Gout; Humans; Kidney Diseases; Kidney Failure, Chronic; Nephritis, Interstitial; Uric Acid | 1987 |
On the mechanism of action of xanthine oxidase. Evidence in support of an oxo transfer mechanism in the molybdenum-containing hydroxylases.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Dithionite; Mass Spectrometry; Milk; Molybdenum; Oxidation-Reduction; Oxygen; Uric Acid; Water; Xanthine; Xanthine Oxidase; Xanthines | 1987 |
Production of uric acid in cerebrospinal fluid after subarachnoid hemorrhage in dogs: investigation of the possible role of xanthine oxidase in chronic vasospasm.
Topics: Allopurinol; Animals; Cerebral Angiography; Dogs; Free Radicals; Ischemic Attack, Transient; Subarachnoid Hemorrhage; Uric Acid; Xanthine Oxidase | 1987 |
Interaction of aluminum hydroxide and allopurinol in patients on chronic hemodialysis.
Topics: Adult; Allopurinol; Aluminum Hydroxide; Drug Administration Schedule; Drug Interactions; Female; Humans; Male; Middle Aged; Renal Dialysis; Uric Acid | 1987 |
The role of oxalate and calcium oxalate activity and formation product ratio in patients with renal stones before and during treatment.
Topics: Allopurinol; Calcium; Calcium Oxalate; Drug Evaluation; Female; Hydrochlorothiazide; Hydrogen-Ion Concentration; Kidney Calculi; Male; Oxalates; Uric Acid | 1987 |
Liquid chromatography with multichannel ultraviolet detection used for studying disorders of purine metabolism.
Topics: Adenine; Allopurinol; Chromatography, High Pressure Liquid; Humans; Hypoxanthine; Hypoxanthines; Inosine; Oxypurinol; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Spectrophotometry, Ultraviolet; Uric Acid; Uridine; Xanthine; Xanthines | 1987 |
Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium.
Topics: Allopurinol; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Glucose; In Vitro Techniques; Liver; Male; Oxygen Consumption; Perfusion; Platelet Activating Factor; Potassium; Rats; Rats, Inbred Strains; Stimulation, Chemical; Uric Acid | 1987 |
Plasma oxipurinol concentrations during allopurinol therapy.
Topics: Allopurinol; Creatine; Gout; Humans; Hypoxanthine; Hypoxanthines; Kidney Function Tests; Oxypurinol; Pyrimidines; Uric Acid; Xanthine; Xanthines | 1987 |
Parathyroid hormone and electrolytes during long-term treatment with allopurinol and thiazide.
Topics: Adult; Allopurinol; Benzothiadiazines; Calcium; Diuretics; Drug Therapy, Combination; Electrolytes; Humans; Male; Middle Aged; Parathyroid Hormone; Recurrence; Sodium Chloride Symporter Inhibitors; Time Factors; Uric Acid; Urinary Calculi | 1987 |
Medical treatment of idiopathic calcium nephrolithiasis.
Topics: Allopurinol; Amiloride; Calcium; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hyperoxaluria; Kidney Calculi; Recurrence; Retrospective Studies; Uric Acid | 1987 |
Study of the effect of hypouricaemic therapy on serum lipid levels in gout patients.
Topics: Allopurinol; Cholesterol; Cholesterol, HDL; Gout; Humans; Lipids; Probenecid; Triglycerides; Uric Acid | 1986 |
The sex steroids influence on uric acid binding to human plasma proteins.
Topics: Adolescent; Adult; Allopurinol; Blood Proteins; Child; Child, Preschool; Female; Gout; Humans; Male; Menopause; Menstrual Cycle; Progesterone; Prolactin; Protein Binding; Reference Values; Sex Factors; Testosterone; Uric Acid | 1986 |
Deamination of guanine to xanthine: a metabolic pathway of underestimated importance in human purine catabolism?
Topics: Allopurinol; Female; Gilbert Disease; Guanine; Humans; Kinetics; Liver Cirrhosis, Biliary; Male; Reference Values; Uric Acid; Xanthine; Xanthines | 1986 |
Dose dependency of the uric acid lowering effects of allopurinol in the presence and absence of dietary purines.
Topics: Adult; Allopurinol; Diet; Female; Humans; Male; Orotic Acid; Purines; Uric Acid | 1986 |
The effect of allopurinol on cerebral spinal fluid (CSF) purines in hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency syndromes.
Topics: Adolescent; Allopurinol; Child; Child, Preschool; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Lesch-Nyhan Syndrome; Purines; Uric Acid | 1986 |
Effect of allopurinol on caffeine disposition in man.
Topics: Adult; Allopurinol; Biotransformation; Caffeine; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Kidney; Kinetics; Male; Uric Acid; Xanthine Oxidase; Xanthines | 1986 |
The mackerel was in fact a red herring.
Topics: Allopurinol; Diagnostic Errors; Drug Hypersensitivity; Female; Food Hypersensitivity; Humans; Medical History Taking; Middle Aged; Uric Acid | 1986 |
2,8-Dihydroxyadenine lithiasis.
Topics: Adenine; Adenine Phosphoribosyltransferase; Allopurinol; Diagnosis, Differential; Humans; Kidney Calculi; Uric Acid | 1986 |
Allopurinol in renal failure and the tumour lysis syndrome.
Topics: Adult; Allopurinol; Child; Child, Preschool; Creatinine; Female; Humans; Infant; Kidney Failure, Chronic; Male; Middle Aged; Monitoring, Physiologic; Oxypurinol; Purines; Uric Acid | 1986 |
Kinetics of allopurinol and oxipurinol after chronic oral administration. Interaction with benzbromarone.
Topics: Adult; Allopurinol; Benzbromarone; Benzofurans; Creatinine; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Oxypurinol; Pyrimidines; Uric Acid | 1986 |
The transport of uric acid across mouse small intestine in vitro.
Topics: Allopurinol; Animals; Biological Transport; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Mice; Mice, Inbred BALB C; Oxypurinol; Serous Membrane; Uracil; Uric Acid | 1986 |
[A case of idiopathic hypouricemia due to augmented renal tubular secretion of uric acid].
Topics: Aged; Allopurinol; Bicarbonates; Humans; Kidney Calculi; Kidney Tubules; Male; Uric Acid | 1986 |
[Combined sulfite and xanthine oxidase deficiency due to an anomaly in the metabolism of molybdenum cofactor].
Topics: Coenzymes; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Metalloproteins; Molybdenum; Molybdenum Cofactors; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Pteridines; Sulfites; Uric Acid; Xanthine Oxidase | 1986 |
[Sulfite and xanthine oxidase deficiency: a diagnosis based on 2 simple tests].
Topics: Coenzymes; Female; Humans; Infant; Metabolism, Inborn Errors; Metalloproteins; Methods; Molybdenum; Molybdenum Cofactors; Oxidoreductases; Oxidoreductases Acting on Sulfur Group Donors; Pteridines; Sulfites; Uric Acid; Xanthine Oxidase | 1986 |
Monosodium urate crystals in the knee joints of patients with asymptomatic nontophaceous gout.
Topics: Allopurinol; Crystallization; Female; Gout; Humans; Joints; Knee Joint; Male; Synovial Fluid; Uric Acid | 1986 |
Phase I trial of tiazofurin administered by i.v. bolus daily for 5 days, with pharmacokinetic evaluation.
Topics: Adult; Aged; Allopurinol; Antimetabolites, Antineoplastic; Creatine Kinase; Drug Administration Schedule; Drug Evaluation; Female; Headache; Hemoglobins; Humans; Hypoxanthines; Isoenzymes; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Nausea; Purines; Ribavirin; Ribonucleosides; Uric Acid; Xanthine; Xanthines | 1987 |
[Drug therapy of hyperuricemia].
Topics: Allopurinol; Drug Therapy, Combination; Gout; Humans; Uric Acid; Uricosuric Agents | 1986 |
Hereditary xanthinuria. Evidence for enhanced hypoxanthine salvage.
Topics: Adenine; Adenine Nucleotides; Adolescent; Adult; Female; Fructose; Guanosine; Humans; Hypoxanthine; Hypoxanthines; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1987 |
Evidence for a pathogenetic role of xanthine oxidase in the "stunned" myocardium.
Topics: Allopurinol; Animals; Blood Gas Analysis; Body Temperature; Coronary Circulation; Coronary Disease; Dogs; Half-Life; Hematocrit; Hemodynamics; Kinetics; Myocardium; Oxypurinol; Potassium; Regional Blood Flow; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1987 |
Cerebrospinal fluid levels of uric acid in dogs and the effect of allopurinol.
Topics: Allopurinol; Animals; Blood-Brain Barrier; Brain; Dogs; Injections, Intravenous; Kinetics; Uric Acid; Xanthine Oxidase | 1987 |
Identification of hypoxanthine transport and xanthine oxidase activity in brain capillaries.
Topics: Adenine; Allopurinol; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Ischemia; Capillaries; Cerebral Cortex; Hypoxanthine; Hypoxanthines; Kinetics; Rats; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1985 |
Effect of anti-inflammatory drugs on xanthine oxidase and xanthine oxidase induced depolymerization of hyaluronic acid.
Topics: Anti-Inflammatory Agents; Free Radicals; Hyaluronic Acid; Kinetics; Macromolecular Substances; Oxygen Consumption; Uric Acid; Viscosity; Xanthine Oxidase | 1985 |
The development of allopurinol.
Topics: Allopurinol; Animals; Chemistry; Coronary Disease; Gout; History, 20th Century; Humans; Hypertension; Leukemia, Myeloid; National Institutes of Health (U.S.); Nephritis, Interstitial; Purines; United States; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1985 |
[Life-threatening interaction between azathioprine and allopurinol].
Topics: Allopurinol; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Synergism; Drug Therapy, Combination; Graft Rejection; Hemolysis; Humans; Kidney Transplantation; Male; Middle Aged; Pancreatitis; Pancytopenia; Postoperative Complications; Uric Acid | 1985 |
Asymptomatic hyperuricaemia and allopurinol induced toxic epidermal necrolysis.
Topics: Adult; Aged; Allopurinol; Female; Humans; Male; Middle Aged; Stevens-Johnson Syndrome; Uric Acid | 1985 |
Xanthine calculi in the patient with the Lesch-Nyhan syndrome associated with urinary tract infection.
Topics: Allopurinol; Child; Combined Modality Therapy; Enterococcus faecalis; Humans; Kidney Calculi; Lesch-Nyhan Syndrome; Male; Proteus Infections; Quaternary Ammonium Compounds; Streptococcal Infections; Uric Acid; Urinary Tract Infections; Xanthine; Xanthines | 1985 |
Gravel passers.
Topics: Adolescent; Adult; Aged; Allopurinol; Combined Modality Therapy; Female; Fluid Therapy; Humans; Male; Middle Aged; Retrospective Studies; Uric Acid; Urinary Calculi | 1985 |
Reversed-phase liquid-chromatographic determination of purine compounds in serum applied to studies of hypouricemia.
Topics: Adult; Aged; Allopurinol; Chromatography, High Pressure Liquid; Colorimetry; Female; Humans; Hypoxanthine; Hypoxanthines; Male; Metabolic Diseases; Middle Aged; Oxypurinol; Purines; Uric Acid; Xanthine; Xanthines | 1986 |
Fatal aplastic anemia associated with allopurinol therapy.
Topics: Allopurinol; Anemia, Aplastic; Humans; Male; Middle Aged; Uric Acid | 1986 |
[Allopurinol in the treatment of psoriasis patients].
Topics: Adult; Allopurinol; Drug Evaluation; Female; Humans; Male; Middle Aged; Psoriasis; Uric Acid | 1986 |
Hyperuricemia and gout.
Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis; Colchicine; Female; Gout; Humans; Indomethacin; Kidney Calculi; Male; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1985 |
Xanthine-containing calculi during allopurinol therapy.
Topics: Adult; Allopurinol; Humans; Hypoxanthine; Hypoxanthines; Kidney Calculi; Lesch-Nyhan Syndrome; Male; Oxypurinol; Uric Acid; Xanthine; Xanthines | 1985 |
Examination of the urinary potential of hyperuricosuric patients to retard calcium oxalate precipitation.
Topics: Allopurinol; Calcium Oxalate; Chemical Precipitation; Female; Humans; Kidney Calculi; Male; Purines; Uric Acid | 1985 |
In vivo voltammetric evidence of production of uric acid by rat caudate.
Topics: Allopurinol; Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Electrochemistry; Male; Rats; Rats, Inbred Strains; Uric Acid | 1985 |
Sulphinpyrazone dose schedule in hyperuricemic patients with cardiovascular diseases: tolerability assessment.
Topics: Allopurinol; Cardiovascular Diseases; Creatinine; Drug Tolerance; Female; Humans; Kidney Function Tests; Male; Middle Aged; Sulfinpyrazone; Uremia; Uric Acid | 1985 |
Renal xanthine stone in Lesch-Nyhan syndrome treated with allopurinol.
Topics: Allopurinol; Child; Humans; Kidney; Kidney Calculi; Lesch-Nyhan Syndrome; Male; Uric Acid; Xanthines | 1985 |
Allopurinol treatment of renal calcium stone disease.
Topics: Adolescent; Adult; Allopurinol; Calcium; Female; Humans; Kidney Calculi; Male; Middle Aged; Recurrence; Uric Acid | 1985 |
Kidney stones. Medical management and newer options for stone 'removal'.
Topics: Allopurinol; Benzothiadiazines; Calcium; Cellulose; Citrates; Citric Acid; Cystoscopy; Diuretics; Fluid Therapy; Fluoroscopy; Humans; Kidney Calculi; Lithotripsy; Medical History Taking; Minerals; Oxalates; Phosphates; Pyridoxine; Sodium Chloride Symporter Inhibitors; Ureteral Calculi; Uric Acid; Urine | 1985 |
[When does allopurinol treatment fail in recurring calcium lithiasis?].
Topics: Allopurinol; Calcium; Follow-Up Studies; Humans; Recurrence; Uric Acid; Urinary Calculi | 1985 |
Adenine therapy in Lesch-Nyhan syndrome.
Topics: Adenine; Allopurinol; Child; Drug Therapy, Combination; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Purines; Uric Acid | 1985 |
Allopurinol, purines, and pyrimidines.
Topics: Allopurinol; Diphosphates; Guanine; Humans; Hypoxanthines; Nucleotides; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidines; Transferases; Uric Acid; Xanthine Oxidase | 1971 |
Allopurinol treatment of uric-acid disorders in calcium-stone formers.
Topics: Adult; Allopurinol; Calcium; Female; Follow-Up Studies; Humans; Kidney Calculi; Male; Metabolic Diseases; Middle Aged; Radiography; Uric Acid | 1973 |
Nucleic acids enzymes in human hair roots.
Topics: Acid Phosphatase; Aminohydrolases; Deoxycytidine; Deoxyribonucleases; Deoxyribonucleosides; Deoxyuridine; DNA; Hair; Humans; Keratins; Nucleic Acids; Nucleoproteins; Nucleosides; Nucleotides; Pentosyltransferases; Phosphoric Diester Hydrolases; Purines; Ribonucleases; RNA; Uric Acid; Xanthine Oxidase | 1973 |
Editorial: Hyperuricaemic acute renal failure.
Topics: Acute Kidney Injury; Adult; Allopurinol; Diuretics; Humans; Renal Dialysis; Ureteral Obstruction; Uric Acid; Urinary Catheterization | 1974 |
Letter: Allopurinol and bone-marrow depression.
Topics: Acute Kidney Injury; Allopurinol; Bone Marrow; Cyclophosphamide; Drug Synergism; Humans; Neoplasms; Uric Acid | 1974 |
Problems faced by hypertensive patients.
Topics: Adrenergic beta-Antagonists; Allopurinol; Blood Pressure; Contraceptives, Oral; Diuretics; Family Practice; Female; Humans; Hypertension; Mass Screening; Metabolic Diseases; Methyldopa; Middle Aged; Physician-Patient Relations; Uric Acid; Urography | 1973 |
Gout and the kidney.
Topics: Allopurinol; Gout; Humans; Kidney Failure, Chronic; Uric Acid; Uricosuric Agents | 1968 |
Effect of allopurinol on pyrimidine metabolism in the Lesch-Nyhan syndrome.
Topics: Allopurinol; Athetosis; Child; Chorea; Compulsive Behavior; Humans; Intellectual Disability; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidines; Self Mutilation; Uric Acid | 1970 |
Gout.
Topics: Allopurinol; Arthritis, Rheumatoid; Chondrocalcinosis; Colchicine; Diagnosis, Differential; Gout; Humans; Long-Term Care; Oxyphenbutazone; Phenylbutazone; Uric Acid | 1973 |
Mechanisms of renal excretion of urate in the rat.
Topics: Allopurinol; Animals; Diuresis; Haplorhini; Hypoxanthines; Inulin; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Mannitol; Microscopy, Fluorescence; Rats; Species Specificity; Uric Acid | 1974 |
[Renal electrolyte changes by allopurinol. A contribution in the prophylaxis of oxalic acid stones (author's transl)].
Topics: Allopurinol; Calcium; Humans; Kidney; Long-Term Care; Oxalates; Uric Acid; Urinary Calculi | 1974 |
[Simplification of allopurinol treatment].
Topics: Allopurinol; Dosage Forms; Drug Evaluation; Gout; Half-Life; Humans; Uric Acid | 1974 |
Drugs in the treatment of hyperuricemia.
Topics: Allopurinol; Gout; Humans; Oxypurinol; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1974 |
The Lesch-Nyhan syndrome.
Topics: Adolescent; Adult; Allopurinol; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Lesch-Nyhan Syndrome; Male; Uric Acid | 1974 |
Catalysis of the direct transfer of oxygen from nicotinamide N-oxide to xanthine by xanthine oxidase.
Topics: Animals; Catalysis; Liver; Milk; Niacinamide; Oxides; Oxygen; Oxygen Isotopes; Uric Acid; Xanthine Oxidase | 1966 |
The excretion of urinary dehydroepiandrosterone in gout.
Topics: 17-Ketosteroids; Adult; Aged; Allopurinol; Arthritis; Dehydroepiandrosterone; Gout; Humans; Joint Diseases; Middle Aged; Uric Acid | 1968 |
[Hyperuricemia and gout in childhood (Lesch-Nyhan syndrome)].
Topics: Adolescent; Athetosis; Brain; Child; Child, Preschool; Compulsive Behavior; Gout; Humans; Huntington Disease; Infant; Infant, Newborn; Intellectual Disability; Kidney Diseases; Liver; Prognosis; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Self Mutilation; Transferases; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1971 |
Excess of ampicillin rashes associated with allopurinol or hyperuricemia. A report from the Boston Collaborative Drug Surveillance Program, Boston University Medical Center.
Topics: Allopurinol; Ampicillin; Boston; Drug Eruptions; Drug Synergism; Female; Gout; Hospitalization; Humans; Male; Middle Aged; Sex Factors; Uric Acid | 1972 |
[Lesch-Nyhan syndrome].
Topics: Allopurinol; Athetosis; Child; Compulsive Behavior; Diet Therapy; Humans; Huntington Disease; Intellectual Disability; Lesch-Nyhan Syndrome; Male; Uric Acid | 1974 |
Digestion of purine ribonucleotides by intestinal enzymes of the developing rat fetus.
Topics: Adenine Nucleotides; Allantoin; Aminohydrolases; Animals; Chromatography, Paper; Fetus; Guanine Nucleotides; In Vitro Techniques; Intestine, Small; Nucleosides; Phosphoric Monoester Hydrolases; Phosphotransferases; Rats; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1965 |
[Therapy of gout with allopurinol. (Study of 106 cases)].
Topics: Adult; Allopurinol; Gout; Humans; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 1967 |
[The effects of allopurinol in gout patients with uric urinary lithiasis or hyperuraturia].
Topics: Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Uric Acid; Urinary Calculi | 1967 |
Recent developments in the therapy of gout.
Topics: Acute Disease; Adrenocorticotropic Hormone; Allopurinol; Analgesics; Colchicine; Gout; Humans; Oxyphenbutazone; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1968 |
Biochemical studies of purine catabolism in Ceratitis capitata.
Topics: Animals; Binding Sites; Charcoal; Chromatography, Paper; Diptera; Electrophoresis; Female; Head; Hypoxanthines; Male; NAD; Uric Acid; Xanthine Oxidase; Xanthines | 1968 |
The regulation of rat liver xanthine oxidase. Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O).
Topics: Animals; Chymotrypsin; Female; Hydrogen-Ion Concentration; Liver; Male; Methylene Blue; NAD; Nitrogen; Oxygen; Rats; Surface-Active Agents; Trypsin; Uric Acid; Xanthine Oxidase; Xanthines | 1969 |
Complex-formation between reduced xanthine oxidase and purine substrates demonstrated by electron paramagnetic resonance.
Topics: Binding Sites; Electron Spin Resonance Spectroscopy; Freezing; Molybdenum; Purines; Uric Acid; Xanthine Oxidase; Xanthines | 1969 |
Depletion of erythrocyte phosphoribosylpyrophosphate in man.
Topics: Administration, Oral; Adult; Allopurinol; Diphosphates; Erythrocytes; Female; Gout; Hemolysis; Humans; In Vitro Techniques; Male; Middle Aged; Nucleotides; Purines; Pyrazoles; Pyrimidines; Ribose; Uric Acid; Xanthine Oxidase | 1970 |
The purine revolution.
Topics: Allopurinol; Diphosphates; Erythrocytes; Gout; Humans; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribose; Transferases; Uric Acid | 1970 |
[Uric acid inhibitors in the treatment of gout. Apropos of 126 cases].
Topics: Adult; Aged; Allopurinol; Colchicine; Drug Synergism; Female; Gout; Humans; Kidney Calculi; Kidney Failure, Chronic; Male; Middle Aged; Phenylbutazone; Pyrazoles; Pyrimidines; Sulfhydryl Compounds; Uric Acid | 1970 |
[Effect of colchicine and allopurinol on uricogenesis. I. Kinetics of their inhibitory action on hepatic xanthine dehydrogenase].
Topics: Allopurinol; Animals; Chickens; Colchicine; Dialysis; Drug Synergism; Kinetics; Liver; NAD; Time Factors; Uric Acid; Xanthine Oxidase; Xanthines | 1970 |
Concentration and synthesis of phosphoribosylpyrophosphate in erythrocytes from normal, hyperuricemic, and gouty subjects.
Topics: Adenosine Diphosphate; Allopurinol; Diphosphates; Erythrocytes; Feedback; Female; Glycerophosphates; Gout; Guanine Nucleotides; Humans; Male; Middle Aged; Pentosephosphates; Phosphoric Acids; Purines; Transferases; Uric Acid | 1971 |
[Xanthine-oxidoreductase (E.C.1.2.3.2.) activity in riboflavin or thiamine deficient rat liver].
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Creatinine; Diet; DNA; Evaluation Studies as Topic; Inosine; Liver; Male; Methods; Methylene Blue; NAD; Phosphorus; Proteins; Rats; Riboflavin Deficiency; Stimulation, Chemical; Thiamine Deficiency; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
Genetic control of enzyme structure in hyperuricemia.
Topics: Aedes; Animals; Chromatography, Paper; Diet; Electrophoresis, Disc; Genotype; Heterozygote; Homozygote; Hypoxanthines; Larva; Molecular Biology; NAD; Purines; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
Management of chronic and recurrent gout.
Topics: Adrenocorticotropic Hormone; Allopurinol; Chronic Disease; Colchicine; Dexamethasone; Diet Therapy; Gout; Humans; Indomethacin; Lidocaine; Phenylbutazone; Prednisolone; Probenecid; Recurrence; Synovial Fluid; Uric Acid | 1971 |
Xanthine dehydrogenase and pteridine metabolism in Colias butterflies.
Topics: Allopurinol; Ammonium Sulfate; Animals; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Electrophoresis; Electrophoresis, Paper; Hypoxanthines; Insecta; Kinetics; NAD; Pteridines; Pterins; Pupa; Purines; Pyrimidines; Uric Acid; Wings, Animal; Xanthine Oxidase; Xanthopterin | 1972 |
Accelerated erythrocyte 5-phosphoribosyl-1-pyrophosphate synthesis. A familial abnormality associated with excessive uric acid production and gout.
Topics: Adult; Allopurinol; Diphosphates; Erythrocytes; Gout; Guanine; Humans; Hypoxanthines; Male; Nucleotides; Pentosephosphates; Pentosyltransferases; Purines; Ribose; Uric Acid | 1972 |
[Uricoeliminating or urico-inhibiting agents? Reasons for a choice].
Topics: Allopurinol; Colchicine; Diet Therapy; Glomerular Filtration Rate; Gout; Humans; Long-Term Care; Orotic Acid; Pyrazoles; Pyrimidines; Sulfhydryl Compounds; Uric Acid; Uricosuric Agents | 1972 |
Gout.
Topics: Adrenocorticotropic Hormone; Allopurinol; Colchicine; Diet; Extracellular Space; Gout; Humans; Indomethacin; Kidney Concentrating Ability; Pentosyltransferases; Phenylbutazone; Purines; Synovial Fluid; Uric Acid; Uricosuric Agents; Urinary Calculi | 1973 |
Familial gouty malignant uric acid lithiasis due to mutant phosphoribosylpyrophosphate synthetase.
Topics: Adult; Allopurinol; Child; Child, Preschool; Diphosphates; Erythrocytes; Female; Gout; Humans; Infant; Kidney Calculi; Male; Metabolism, Inborn Errors; Phosphotransferases; Purines; Uric Acid | 1973 |
Pathology of gout.
Topics: Allopurinol; Arthritis; Calcium Phosphates; Cartilage, Articular; Chondrocalcinosis; Crystallization; Diphosphates; Gout; Humans; Kidney Diseases; Kidney Tubules; Leukocytes; Macrophages; Myeloproliferative Disorders; Synovial Fluid; Uric Acid | 1973 |
An unusual case of glycogen storage disease.
Topics: Alanine Transaminase; Allopurinol; Aspartate Aminotransferases; Blood Glucose; Carbon Radioisotopes; Child; Cholesterol; Epinephrine; Fasting; Fatty Acids, Nonesterified; Female; Galactose; Glucagon; Glucose-6-Phosphatase; Glucosidases; Glycerol; Glycogen; Glycogen Storage Disease; Humans; Lactates; Leukocytes; Male; Phosphorylases; Time Factors; Tritium; Uric Acid | 1973 |
Studies on the mechanism of fructose-induced hyperuricemia in man.
Topics: Adenosine Triphosphate; Allopurinol; Blood Glucose; Carbohydrates; Erythrocytes; Fructose; Lactates; Male; Pentosephosphates; Phosphates; Phosphoric Acids; Purines; Time Factors; Uric Acid | 1974 |
Xanthine oxidase deficiency: studies of a previously unreported case.
Topics: Adult; Allopurinol; Diet; Humans; Hypoxanthines; Intestinal Mucosa; Male; Organophosphorus Compounds; Orotic Acid; Pentosephosphates; Phosphoric Acids; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidines; Uric Acid; Xanthine Oxidase; Xanthines | 1974 |
Effects of a high protein, "carbohydrate-free" diet on liver and kidney constituents and kidney function in chicks.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chickens; Dietary Proteins; Hypertrophy; Kidney; Kidney Diseases; Kidney Function Tests; Liver; Male; Potassium; Protein Biosynthesis; Time Factors; Uric Acid; Xanthine Oxidase | 1971 |
Effect of allopurinol (4-hydroxyprazolo(3,4-d)pyrimidine) on xanthine accumulation by milk xanthine oxidase in vitro.
Topics: Adenine; Allopurinol; Animals; Antimetabolites; Aza Compounds; Azaguanine; Hypoxanthines; In Vitro Techniques; Mercaptopurine; Milk; Oxidoreductases; Purines; Spectrophotometry; Uric Acid; Xanthine Oxidase; Xanthines | 1974 |
Gout and hyperlipidaemia.
Topics: Adult; Aged; Alcohol Drinking; Allopurinol; Aspartate Aminotransferases; Body Height; Body Weight; Cholesterol; Gout; Humans; Hyperlipidemias; Liver; Male; Middle Aged; Obesity; Probenecid; Sulfobromophthalein; Triglycerides; Uric Acid | 1974 |
Progressive seizures with hyperuricosuria reversed by allopurinol.
Topics: Allopurinol; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Humans; Infant; Intellectual Disability; Male; Neurologic Manifestations; Purine-Pyrimidine Metabolism, Inborn Errors; Seizures; Uric Acid | 1974 |
Withdrawal of allopurinol in patients with gout.
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Recurrence; Substance Withdrawal Syndrome; Urea; Uric Acid | 1974 |
Letter: Drugs used in hyperuricaemia.
Topics: Allopurinol; Anti-Inflammatory Agents; Gout; Humans; Metabolic Diseases; Uric Acid | 1974 |
Treatment of renal calculi.
Topics: Alkalies; Allopurinol; Ammonia; Calcium; Cystine; Dehydration; Humans; Kidney Calculi; Magnesium; Phosphates; Phosphorus; Thiazines; Uric Acid; Urinary Tract Infections | 1974 |
[Lesch-Nyhan syndrome].
Topics: Allopurinol; Humans; Infant; Lesch-Nyhan Syndrome; Male; Uric Acid | 1974 |
Letter: A clinical impression of benzbromarone (Minuric).
Topics: Adult; Allopurinol; Benzoates; Benzofurans; Bromine; Gout; Gout Suppressants; Humans; Male; Metabolic Diseases; Uric Acid | 1974 |
Thiopurinol and purine metabolism. Metabolic and radioisotope studies.
Topics: Allantoin; Allopurinol; Animals; Autoradiography; Carbon Radioisotopes; Feces; Hypoxanthines; Kidney; Liver; Male; Orotic Acid; Purines; Sulfhydryl Compounds; Swine; Time Factors; Uric Acid; Xanthines | 1974 |
[Editorial: Therapy of gout nowadays (author's transl)].
Topics: Allopurinol; Colchicine; Exercise Therapy; Gout; Humans; Uric Acid; Uricosuric Agents | 1974 |
[The effect of daily single doses of 300 mg allopurinol on serum uric acid concentration and urate excretion in gouty patients (author's transl)].
Topics: Allopurinol; Analysis of Variance; Gout; Humans; Metabolic Clearance Rate; Uric Acid | 1974 |
[Scury and purine catabolism].
Topics: Adenine; Allantoin; Animals; Ascorbic Acid Deficiency; Guanine; Guinea Pigs; Purines; Scurvy; Stimulation, Chemical; Urate Oxidase; Urea; Uric Acid; Xanthine Oxidase | 1974 |
Effect of allopurinol in gouty patients given long term corticotherapy.
Topics: Adrenal Cortex Hormones; Allopurinol; Dose-Response Relationship, Drug; Gout; Humans; Purines; Uric Acid | 1974 |
Effect of Milurit on decreasing hyperuricaemia in hypertensive patients.
Topics: Allopurinol; Glomerular Filtration Rate; Gout; Humans; Hypertension; Thiazines; Uric Acid | 1974 |
[The effect of fructose on uric acid metabolism].
Topics: Allopurinol; Animals; Diuresis; Fasting; Fructose; Gout; Humans; Male; Oxonic Acid; Rats; Urate Oxidase; Uremia; Uric Acid | 1974 |
Clinical and biochemical studies on treatment of Lesch-Nyhan syndrome.
Topics: Adenine; Allopurinol; Body Weight; Child, Preschool; Chlorpromazine; Creatinine; Exchange Transfusion, Whole Blood; Humans; Language Development; Lesch-Nyhan Syndrome; Male; Motor Skills; Movement Disorders; Pedigree; Pentosyltransferases; Phenothiazines; Tetrabenazine; Uric Acid | 1974 |
Current medical practice and the Food and Drug Administration. Some evidence for the existing gap.
Topics: Adult; Aged; Allopurinol; Angina Pectoris; Cephalexin; Child; Colchicine; Diuretics; Drug Labeling; Drug Prescriptions; Drug Therapy; Gout; Humans; Hypertension; Iron; Middle Aged; Physicians; Postoperative Complications; Propranolol; Retrospective Studies; United States; United States Food and Drug Administration; Uric Acid | 1974 |
Understanding hyperuricemia: nursing implications.
Topics: Allopurinol; Diabetes Mellitus; Diet Therapy; Gout; Humans; Kidney Diseases; Metabolic Diseases; Uric Acid; Uricosuric Agents; Vascular Diseases | 1972 |
Allopurinol in the treatment of an intractable metabolically-derived dermatosis in a Dalmatian dog.
Topics: Allopurinol; Animals; Dermatitis; Dog Diseases; Dogs; Female; Uric Acid; Urinary Calculi | 1973 |
Management of acute renal failure due to marked hyperuricemia.
Topics: Acute Kidney Injury; Adolescent; Allopurinol; Bicarbonates; Humans; Infusions, Parenteral; Kidney; Leukemia, Lymphoid; Male; Methotrexate; Potassium; Prednisone; Radiography; Regional Blood Flow; Renal Dialysis; Sodium; Thrombocytopenia; Uric Acid; Vincristine | 1972 |
The Lesch-Nyhan syndrome: report of three cases.
Topics: Adenine; Adolescent; Adult; Allopurinol; Athetosis; Australia; Child; Humans; Hypoxanthines; Intellectual Disability; Lesch-Nyhan Syndrome; Male; Phosphotransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Uric Acid; Xanthines | 1972 |
[Hyperuricemia caused by cytostatic drugs and treated with Milurit].
Topics: Allantoin; Allopurinol; Antineoplastic Agents; Female; Humans; Leukemia, Myeloid; Middle Aged; Uric Acid | 1973 |
Hyperphosphatemia, hyperphosphaturia and hypocalcemia in acute lymphoblastic leukemia.
Topics: Adolescent; Allopurinol; Asparaginase; Blood Urea Nitrogen; Calcium; Calcium, Dietary; Child; Creatinine; Humans; Hypocalcemia; Kidney Tubules; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Male; Phosphates; Prednisone; Prospective Studies; Uric Acid; Vincristine | 1973 |
[Hypocalcemia and hyperuricemia during treatment of acute lymphoblastic leukemia in childhood].
Topics: Acute Disease; Allopurinol; Child, Preschool; Humans; Hyperkalemia; Hypocalcemia; Leukemia, Lymphoid; Male; Methotrexate; Prednisone; Uric Acid | 1974 |
Proceedings: Treatment of acute leukaemia in adults.
Topics: Acute Disease; Adult; Allopurinol; Anti-Bacterial Agents; Bacterial Infections; Child; Cytarabine; Daunorubicin; Drug Therapy, Combination; Humans; Hydroxyurea; Leukemia; Leukemia, Lymphoid; Metabolic Diseases; Prednisone; Remission, Spontaneous; Thioguanine; Uric Acid; Vincristine | 1974 |
Allopurinol and hypoxanthine pretreatment of canine kidney donors.
Topics: Allopurinol; Animals; Creatinine; Dogs; Drug Therapy, Combination; Graft Rejection; Hypoxanthines; Ischemia; Kidney; Kidney Transplantation; Shock, Hemorrhagic; Transplantation, Homologous; Uric Acid | 1974 |
Effect of allopurinol on the preservation of ischemic kidneys perfused with plasma or plasma substitutes.
Topics: Adenosine Triphosphate; Allopurinol; Animals; Creatinine; Dogs; Kidney; Kidney Function Tests; Kidney Transplantation; Perfusion; Plasma; Plasma Substitutes; Purines; Serum Albumin; Time Factors; Tissue Preservation; Transplantation, Autologous; Uric Acid | 1974 |
Pharmacology of pyrazinamide: metabolic and renal function studies related to the mechanism of drug-induced urate retention.
Topics: Adsorption; Allopurinol; Animals; Biological Transport, Active; Biotransformation; Carboxylic Acids; Colorimetry; Dogs; Female; Filtration; Haplorhini; Humans; Inulin; Kidney; Kidney Function Tests; Kidney Tubules; Male; Metabolism; Pyrazinamide; Pyrazines; Uric Acid; Uricosuric Agents | 1972 |
[Regression of gout tophi under long-term therapy with allopurinol].
Topics: Aged; Allopurinol; Female; Fingers; Gout; Humans; Joint Diseases; Joints; Long-Term Care; Male; Middle Aged; Radiography; Regression, Psychology; Skin Manifestations; Toes; Uric Acid | 1972 |
Influence of allopurinol and azaserine on nitrogen metabolism in the chick.
Topics: Administration, Oral; Alanine; Allopurinol; Ammonia; Animals; Azaserine; Carbon Isotopes; Chickens; Depression, Chemical; Dietary Proteins; Glycine; Injections, Intraperitoneal; Ketone Oxidoreductases; Liver; Male; Nitrogen; Purines; Quaternary Ammonium Compounds; Uric Acid; Xanthines | 1972 |
[Urolithiasis in gout and hyperuricemic syndrome].
Topics: Allopurinol; Colchicine; Diabetes Complications; Diabetes Mellitus; Female; Gout; Humans; Male; Uric Acid; Urinary Calculi | 1972 |
[Kidney involvement in gout].
Topics: Adolescent; Adult; Aged; Allopurinol; Anti-Bacterial Agents; Antihypertensive Agents; Female; Gout; Humans; Kidney Calculi; Kidney Diseases; Male; Middle Aged; Nephritis, Interstitial; Nephrosclerosis; Pyelonephritis; Uric Acid; Uricosuric Agents | 1972 |
[Dissolution of a giant staghorn uric calculus by medical treatment].
Topics: Allopurinol; Diet Therapy; Humans; Male; Middle Aged; Radionuclide Imaging; Uric Acid; Urinary Calculi; Urography; Xanthine Oxidase | 1972 |
[Molecular bases of the treatment of Lesch-Nyhan syndrome, related syndromes and common gout].
Topics: Adenine Nucleotides; Allopurinol; Feedback; Gout; Guanosine; Humans; Hypoxanthines; Lesch-Nyhan Syndrome; Orotic Acid; Pentosyltransferases; Pyrazoles; Pyrimidines; Sulfhydryl Compounds; Uric Acid; Xanthine Oxidase | 1972 |
Simultaneous measurement of plasma and erythrocyte oxypurines. II. Gouty patients with and without allopurinol medication.
Topics: Allopurinol; Erythrocytes; Gout; Humans; Hypoxanthines; Male; Purinones; Stimulation, Chemical; Uric Acid; Xanthines | 1972 |
Effect of balneotherapy in Ciechocinek Spa on the occurrence of gouty attacks and the symptoms of chronic gouty arthropathy (observations of 112 cures).
Topics: Adult; Aged; Allopurinol; Balneology; Blood Sedimentation; Colchicine; Female; Gout; Humans; Male; Middle Aged; Probenecid; Uric Acid | 1972 |
[Diagnosis and therapy of gout (uricopathy). Guide lines for daily practice].
Topics: Allopurinol; Arthritis, Rheumatoid; Benzofurans; Diagnosis, Differential; Gout; Humans; Ketones; Psoriasis; Rheumatic Fever; Uric Acid | 1972 |
[An unusual form of juvenile hyperuricemia with mechanical anuria].
Topics: Adolescent; Allopurinol; Anuria; Fasting; Female; Humans; Kidney Calculi; Quinolines; Uric Acid; Uricosuric Agents; Urography | 1972 |
[Idiopathic femur head necrosis with hyperuricemia and dyslipemia in the adult].
Topics: Adolescent; Adrenocortical Hyperfunction; Adult; Aged; Allopurinol; Child; Diet Therapy; Female; Femur Head; Femur Head Necrosis; Hematologic Diseases; Humans; Hyperlipidemias; Lipids; Liver Diseases; Male; Metabolic Diseases; Middle Aged; Phospholipids; Uric Acid | 1972 |
The clinical significance of hypouricemia.
Topics: Allopurinol; Aspirin; Contrast Media; Depression, Chemical; Diet; Female; Guaifenesin; Humans; Liver Diseases; Male; Neoplasms; Osmolar Concentration; Uric Acid | 1973 |
Development of renal gluconeogenesis in chicks fed high fat and high protein "carbohydrate-free" diets.
Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Chick Embryo; Chickens; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Gluconeogenesis; Glycerol; Glycerolphosphate Dehydrogenase; Kidney; Liver; Phosphoenolpyruvate Carboxykinase (GTP); Phosphotransferases; Pyruvates; Uric Acid; Xanthine Oxidase | 1973 |
[The effect of spironolactone and thiabutazide on serum-uric acid and lipid levels in patients with gout and in healthy persons].
Topics: Adult; Allopurinol; Benzothiadiazines; Cholesterol; Female; Follow-Up Studies; Gout; Humans; Lipids; Male; Middle Aged; Spironolactone; Triglycerides; Uric Acid | 1973 |
A simple method for determining low levels of urinary oxypurine.
Topics: Humans; Hydrogen-Ion Concentration; Methods; Purines; Spectrophotometry; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1973 |
[Treatment with allopurinol in gout and hyperuricemic renal disease].
Topics: Adult; Aged; Allopurinol; Creatinine; Female; Glomerular Filtration Rate; Gout; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Uric Acid | 1973 |
Hereditary xanthinuria and xanthine urolithiasis: an additional 3 cases.
Topics: Adult; Child, Preschool; Female; Humans; Liver; Male; Metabolism, Inborn Errors; Middle Aged; Uric Acid; Urinary Calculi; Xanthine Oxidase; Xanthines | 1973 |
Xanthine oxidase from bovine thyroid glands.
Topics: Animals; Cattle; Chromatography; Peroxidases; Spectrophotometry; Thyroid Gland; Uric Acid; Xanthine Oxidase | 1973 |
Platelets and vascular disease in gout.
Topics: Allopurinol; Analgesics; Arteriosclerosis; Blood Platelets; Colchicine; Diabetes Complications; Gout; Halofenate; Humans; Hyperlipidemias; Hypertension; Hypoxanthines; In Vitro Techniques; Kidney Diseases; Uric Acid; Uricosuric Agents; Vascular Diseases; Xanthines | 1973 |
[Long-term therapy of gout and hyperuricemia].
Topics: Allopurinol; Arteriosclerosis; Blood Protein Disorders; Citrates; Colchicine; Diabetes Mellitus; Diet Therapy; Gout; Humans; Hyperlipidemias; Hypertension; Kidney Calculi; Kidney Diseases; Phenylbutazone; Physical Therapy Modalities; Time Factors; Uremia; Uric Acid | 1973 |
[Urinary lithiasis revealing Lesch-Nyhan syndrome].
Topics: Allopurinol; Anemia; Anti-Bacterial Agents; Humans; Infant; Intellectual Disability; Lesch-Nyhan Syndrome; Neurologic Manifestations; Uric Acid; Urinary Calculi; Urinary Tract Infections | 1973 |
Pyrazinoate excretion in the chimpanzee. Relation to urate disposition and the actions of uricosuric drugs.
Topics: Allopurinol; Aminohippuric Acids; Animals; Biological Transport; Carboxylic Acids; Chlorothiazide; Depression, Chemical; Glomerular Filtration Rate; Insulin; Iodopyracet; Kidney Tubules; Male; Organomercury Compounds; Pan troglodytes; Probenecid; Protein Binding; Pyrazines; Salicylates; Stimulation, Chemical; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1973 |
[Results of Allopurinol treatment in patients with hyperuricemia in chronic renal failure].
Topics: Adolescent; Adult; Allopurinol; Female; Humans; Kidney Failure, Chronic; Liver; Male; Middle Aged; Uric Acid | 1973 |
Renal synthesis of uric acid.
Topics: Allopurinol; Aminohippuric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Chickens; Chromatography, Thin Layer; Diuresis; Female; Glomerular Filtration Rate; Kidney; Kidney Tubules; Models, Biological; Oxidation-Reduction; Probenecid; Quinine; Uric Acid; Xanthines | 1973 |
Potent competitive uricase inhibitors--2,8-diazahypoxanthine and related compounds.
Topics: Allantoin; Animals; Aza Compounds; Azaguanine; Cattle; Dose-Response Relationship, Drug; Guanine; Hypoxanthines; In Vitro Techniques; Kidney; Kinetics; Liver; Pentosyltransferases; Pyrazoles; Rats; Time Factors; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1973 |
Xanthine accumulation during hypoxanthine oxidation by milk xanthine oxidase.
Topics: Animals; Chemical Phenomena; Chemistry; Hypoxanthines; Milk; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Time Factors; Uric Acid; Xanthine Oxidase; Xanthines | 1973 |
[Emergencies in oncology].
Topics: Acute Kidney Injury; Adult; Aged; Allopurinol; Breast Neoplasms; Carcinoma; Emergencies; Estradiol; Female; Humans; Hypercalcemia; Male; Neoplasm Metastasis; Neoplasms; Uric Acid | 1973 |
[Allopurinol treatment of patients with uric acid calculi].
Topics: Administration, Oral; Allopurinol; Citrates; Humans; Kidney Calculi; Uric Acid; Urography | 1973 |
Mechanism of antiuric action of 4-oxy- and 4-thiopyrazolopyrimidines.
Topics: Allopurinol; Animals; Carbon Radioisotopes; Cattle; Erythrocytes; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Milk; Nucleotides; Pyrazoles; Pyrimidines; Spectrophotometry; Uric Acid; Xanthine Oxidase | 1973 |
Uric acid metabolism in the tsetse fly, Glossina morsitans.
Topics: Amino Acids; Animals; Larva; Male; Pupa; Starvation; Time Factors; Tsetse Flies; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1973 |
[Hemodynamic and biochemical results following administration of Allopurinol in healthy individuals].
Topics: Adult; Allopurinol; Animals; Blood Glucose; Blood Pressure; Cardiac Output; Cardiac Volume; Coronary Disease; Dogs; Fatty Acids, Unsaturated; Heart Rate; Hemodynamics; Humans; Lipoproteins; Male; Oxygen Consumption; Uric Acid | 1973 |
[Uric acid behavior and significance of xanthineoxidase inhibition by allopurinol in tourniquet shock of the dog].
Topics: Acidosis; Allopurinol; Animals; Bicarbonates; Blood Pressure; Carbon Dioxide; Diuresis; Dogs; Female; Hydrogen-Ion Concentration; Male; Partial Pressure; Shock; Time Factors; Tourniquets; Uric Acid; Xanthine Oxidase | 1973 |
The treatment of gout.
Topics: Acute Disease; Allopurinol; Aspirin; Colchicine; Drug Therapy, Combination; Gout; Indomethacin; Phenylbutazone; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1973 |
Gout with adenine phosphoribosyl transferase deficiency.
Topics: Adenine; Allopurinol; Carbon Radioisotopes; Erythrocytes; Female; Glycine; Gout; Humans; Male; Pedigree; Pentosephosphates; Pentosyltransferases; Purines; Sulfhydryl Compounds; Uric Acid | 1973 |
[Studies on plasma protein binding of uric acid in gout].
Topics: Allopurinol; Blood Protein Electrophoresis; Blood Proteins; Carbon Radioisotopes; Chromatography, Gel; Electrophoresis, Paper; Gout; Humans; Protein Binding; Uric Acid | 1973 |
Hyperuricaemia and urate nephropathy in haemoblastoses.
Topics: Allopurinol; Humans; Kidney Diseases; Leukemia; Uric Acid | 1973 |
[Clinical studies of hyperuricemia. I. Clinical observation and treatment of acute uric acid nephropathy (author's transl)].
Topics: Acute Kidney Injury; Adult; Aged; Allopurinol; Humans; Male; Middle Aged; Uric Acid | 1973 |
Uric acid and the kidney.
Topics: Aged; Allopurinol; Animals; Diabetes Mellitus; Gout; Humans; Hydrogen-Ion Concentration; Hypercholesterolemia; Hypertension; Hypoxanthines; Kidney Calculi; Kidney Diseases; Kidney Failure, Chronic; Swine; Uremia; Uric Acid; Xanthenes; Xanthine Oxidase | 1973 |
[Treatment of uric acid disorders].
Topics: Acute Disease; Allopurinol; Colchicine; Female; Gout; Humans; Male; Uric Acid | 1973 |
[The action of allopurinol on uric acid transport].
Topics: Allopurinol; Biological Transport, Active; Gout; Humans; Male; Middle Aged; Uremia; Uric Acid | 1973 |
Use of Milurit in the treatment of gout.
Topics: Aged; Allopurinol; Drug Administration Schedule; Drug Evaluation; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1973 |
Evaluation of serum cholesterol reduction and xanthine oxidase inhibition in the treatment of atherosclerosis.
Topics: Adult; Aged; Animals; Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Female; Folic Acid; Humans; Male; Middle Aged; Milk; Milk Proteins; Uric Acid; Xanthine Oxidase | 1973 |
Gout.
Topics: Allopurinol; Blood Cell Count; Cell Movement; Colchicine; Diet; Drug Synergism; Gastrointestinal Diseases; Gout; Hemorrhage; Humans; Indomethacin; Leukocytes; Mercaptopurine; Phenylbutazone; Probenecid; Purines; Uric Acid | 1974 |
Pharmacogenetics.
Topics: Abnormalities, Drug-Induced; Allopurinol; Barbiturates; Chromosome Aberrations; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Estrogens; Female; Genetic Diseases, Inborn; Humans; Hyperbilirubinemia, Hereditary; Microsomes, Liver; Mutation; Neoplasms; Pharmaceutical Preparations; Pharmacogenetics; Uric Acid | 1974 |
The treatment of hyperuricemia in gout.
Topics: Allopurinol; Gout; Humans; Uric Acid; Uricosuric Agents | 1974 |
[New drugs: allopurinol. Foligan, Urosin, Zyloric].
Topics: Allopurinol; Germany, West; Gout; Humans; Uric Acid; Uricosuric Agents | 1974 |
[Allopurinol treatment of gout with special reference to patients with gouty nephropathy].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Kidney Diseases; Male; Middle Aged; Uric Acid | 1974 |
Hyperuricemia in leukemia and lymphoma.
Topics: Acetazolamide; Acute Kidney Injury; Allopurinol; Antineoplastic Agents; Bicarbonates; Crystallization; Disease Susceptibility; Diuretics, Osmotic; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Leukemia; Lymphoma; Mannitol; Peritoneal Dialysis; Radiotherapy; Renal Dialysis; Uric Acid | 1974 |
Analysis of treatment results in uric acid lithiasis with and without hyperuricemia.
Topics: Acute Kidney Injury; Allopurinol; Calcium; Humans; Uric Acid; Urinary Calculi | 1974 |
The binding of urate to plasma proteins.
Topics: Allopurinol; Aspirin; Binding Sites; Blood Proteins; Colchicine; Dialysis; Evaluation Studies as Topic; Gout; Humans; Hydrogen-Ion Concentration; Indomethacin; Kidney Diseases; Kinetics; Methods; Osmolar Concentration; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Solubility; Sulfinpyrazone; Temperature; Time Factors; Uric Acid | 1974 |
Efficacy of single daily dose allopurinol in gouty hyperuricemia.
Topics: Allopurinol; Evaluation Studies as Topic; Gout; Half-Life; Humans; Male; Time Factors; Uric Acid | 1974 |
Withdrawal of allopurinol in patients with gout.
Topics: Allopurinol; Evaluation Studies as Topic; Follow-Up Studies; Gout; Humans; Male; Middle Aged; Recurrence; Time Factors; Urea; Uric Acid | 1974 |
Metabolic studies of thiopurinol in man and the pig.
Topics: Adult; Alcohol Drinking; Allopurinol; Animals; Carbon Radioisotopes; Duodenum; Gout; Humans; Hypoxanthines; Kidney; Liver; Lung; Male; Middle Aged; Myocardium; Obesity; Pyrazoles; Pyrimidines; Species Specificity; Spleen; Sulfhydryl Compounds; Swine; Uric Acid; Xanthines | 1974 |
Allopurinol and thiopurinol: effect in vivo on urinary oxypurine excretion and rate of synthesis of their ribonucleotides in different enzymatic deficiencies.
Topics: Adenine; Allopurinol; Erythrocytes; Female; Gout; Guanine; Humans; Hypoxanthines; Lesch-Nyhan Syndrome; Male; Pentosephosphates; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrazoles; Pyrimidines; Sulfhydryl Compounds; Time Factors; Uric Acid; Xanthines | 1974 |
The clinical significance of hypouricemia.
Topics: Allopurinol; Amino Acids; Aspirin; Autoanalysis; Creatinine; Glycosuria; Humans; Kidney Diseases; Neoplasms; Phosphates; Porphobilinogen; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Salicylates; Uric Acid; Xanthine Oxidase | 1974 |
Hyperuricemia induced by ethambutol.
Topics: Allopurinol; Creatinine; Diuretics; Ethambutol; Ethanol; Gout; Humans; Isoniazid; Lactates; Pyrazinamide; Pyridoxine; Salicylates; Stimulation, Chemical; Streptomycin; Time Factors; Tuberculosis; Uric Acid | 1974 |
[Hyperuricemia due to hypoxanthine-guanine-phosphoribosyltransferase deficiency].
Topics: Adult; Allopurinol; Anemia; Arthritis; Benzofurans; Gout; Humans; Hyperlipidemias; Hypothyroidism; Hypoxanthines; Kidney Calculi; Male; Metabolism, Inborn Errors; Pedigree; Pentosyltransferases; Uric Acid; Uricosuric Agents | 1974 |
Pathophysiology of purine metabolism in man.
Topics: Adenosine; Alkaline Phosphatase; Amidinotransferases; Amidohydrolases; Glomerular Filtration Rate; Glucosephosphate Dehydrogenase; Gout; Guanine Nucleotides; Humans; Hypoxanthines; Kinetics; Lesch-Nyhan Syndrome; Pentosephosphates; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribose; Uric Acid; Xanthine Oxidase; Xanthines | 1974 |
Hepatic xanthine dehydrogenase activity and plasma uric acid concentrations of chicks with lymphoid tumor-induced anemia.
Topics: Anemia; Animals; Chickens; Liver; Liver Neoplasms; Lymphoma; Neoplasm Transplantation; Poultry Diseases; Transplantation, Homologous; Uric Acid; Xanthine Oxidase | 1974 |
[Mechanism of action and role of xanthine oxidoreductases (author's transl)].
Topics: Animals; Chemical Phenomena; Chemistry; Chickens; Electron Transport; Flavin-Adenine Dinucleotide; Gout; Humans; Hydroxylation; Hypoxanthines; Iron; Ketone Oxidoreductases; Lesch-Nyhan Syndrome; Liver; Mice; Milk; Molecular Weight; Molybdenum; Purines; Rats; Uric Acid; Xanthine Oxidase; Xanthines | 1974 |
[Multiple aseptic bone necrosis in hyperlipidaemia, hyperuricaemia, and latent diabetes mellitus (author's transl)].
Topics: Adult; Allopurinol; Bone Diseases; Clofibrate; Diet Therapy; Dietary Carbohydrates; Femur Head Necrosis; Humans; Humerus; Hyperlipidemias; Joint Prosthesis; Knee Joint; Lipoproteins; Male; Necrosis; Prediabetic State; Triglycerides; Uric Acid | 1974 |
Editorial: Drugs used in hyperuricaemia.
Topics: Allopurinol; Gout; Humans; Metabolic Diseases; Uric Acid; Uricosuric Agents | 1974 |
Gout with adenine phosphoribosyl transferase deficiency.
Topics: Adenine; Adolescent; Adult; Aged; Allopurinol; Carbon Radioisotopes; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Female; Gout; Humans; Karyotyping; Male; Middle Aged; Pedigree; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribonucleosides; Uric Acid; Xanthines | 1974 |
The Jewish Hospital of St. Louis. Therapeutic grand rounds number 7. An approach to disorders of uric acid metabolism.
Topics: Allopurinol; Alloxan; Feedback; Gout; Guanine; Humans; Hypoxanthines; Kidney; Male; Metabolic Diseases; Middle Aged; Pentosyltransferases; Purines; Uric Acid; Uricosuric Agents; Xanthines | 1974 |
Diminished renal urate secretion per nephron as a basis for primary gout.
Topics: Adult; Allopurinol; Carbon Isotopes; Computers; Dietary Proteins; Gout; Humans; Inulin; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Male; Pyrazinamide; Radioisotope Dilution Technique; Spectrophotometry; Statistics as Topic; Urate Oxidase; Uric Acid | 1970 |
[Clinical and biological aspects of dyspurinia with enzyme deficiency].
Topics: Adult; Allopurinol; Gout; Guanine; Humans; Hypoxanthines; Joint Diseases; Kidney Calculi; Metabolism, Inborn Errors; Molecular Biology; Phosphotransferases; Purines; Uric Acid | 1970 |
[Pharmacology--patient care].
Topics: Allopurinol; Drug Therapy; History, 19th Century; History, 20th Century; History, Medieval; History, Modern 1601-; Humans; Kidney; Pharmacology; Pharmacopoeias as Topic; Probenecid; Uric Acid | 1971 |
Responses of the ischemic myocardium to allopurinol.
Topics: Allopurinol; Animals; Blood Pressure; Cardiac Catheterization; Cardiac Output; Coronary Disease; Coronary Vessels; Dogs; Dye Dilution Technique; Electrocardiography; Heart Rate; Ischemia; Myocardium; Phosphorus; Potassium; Sheep; Sodium; Uric Acid; Vascular Resistance; Venous Pressure; Xanthine Oxidase | 1971 |
Action of 8-azaguanine and 8-azaxanthine on Pseudomonas aeruginosa.
Topics: Antimetabolites; Azaguanine; In Vitro Techniques; Pseudomonas aeruginosa; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 1964 |
Mechanisms of pathogenesis in Listeria monocytogenes infection. II. Characterization of listeriosis in the CD-1 mouse and survey of biochemical lesions.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Female; Lipids; Listeria monocytogenes; Listeriosis; Liver; Mice; Organ Size; Oxidative Phosphorylation; Proteins; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1967 |
The development and use of an intravenous preparation of allopurinol.
Topics: Adult; Allopurinol; Animals; Bone Marrow Examination; Calcium; Child, Preschool; Female; Haplorhini; Humans; Infusions, Parenteral; Kidney; Kidney Function Tests; Leukemia, Lymphoid; Leukemia, Myeloid; Liver Function Tests; Male; Thyroid Function Tests; Uric Acid | 1968 |
[Retroaction effect of certain pyrazolopyrimidines on the metabolism of uric acid].
Topics: Adult; Aged; Allopurinol; Child; Gout; Humans; Pyrimidines; Uric Acid; Xanthine Oxidase; Xanthines | 1968 |
[Allopurinol in the prevention and treatment of urate complications in leukemia].
Topics: Adolescent; Allopurinol; Gout; Humans; Leukemia; Male; Middle Aged; Uric Acid | 1969 |
The etiology of uric acid urolithiasis following ileostomy.
Topics: Colitis, Ulcerative; Humans; Hydrogen-Ion Concentration; Ileostomy; Kidney Function Tests; Parenteral Nutrition; Postoperative Care; Postoperative Complications; Uric Acid; Urinary Calculi; Water-Electrolyte Balance; Xanthine Oxidase | 1969 |
[Xanthine urinary lithiasis and xanthinuria in a dachshund. Deficiency, probably genetic, of the xanthine oxidase system].
Topics: Allantoin; Animals; Dogs; Infrared Rays; Metabolism, Inborn Errors; Purines; Spectrum Analysis; Ultraviolet Rays; Uric Acid; Urinary Calculi; X-Ray Diffraction; Xanthine Oxidase; Xanthines | 1969 |
[Reaction of xanthine oxidase in fluid media at low temperature and by thermoluminescence].
Topics: Luminescent Measurements; Spectrophotometry; Temperature; Uric Acid; Xanthine Oxidase; Xanthines | 1970 |
[Pathogenesis and therapy of gout].
Topics: Allopurinol; Androsterone; Colchicine; Gout; Gymnastics; Humans; Indomethacin; Kinins; Long-Term Care; Metabolism, Inborn Errors; Physical Education and Training; Purine-Pyrimidine Metabolism, Inborn Errors; Time Factors; Uric Acid; Uricosuric Agents | 1971 |
[Inhibition of xanthine oxidase by allopurinol (1 H-5 dihydro-4,5 pyrazolo (3,4-d)pyrimidinone-4) (study of the oxidation process and the effect of aminomethylation)].
Topics: Allopurinol; Animals; Cattle; Chemical Phenomena; Chemistry; In Vitro Techniques; Kinetics; Methylation; Mice; Milk; Oxidation-Reduction; Rats; Spectrophotometry; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
Primary hyperoxaluria with normal alpha-ketoglutarate: glyoxylate carboligase activity. Treatment with isocarboxazid.
Topics: Allopurinol; Child; Female; Glycolates; Glyoxylates; Humans; Isocarboxazid; Ketoglutaric Acids; Kidney Calculi; Metabolism, Inborn Errors; Muscles; Oxalates; Pyridoxine; Uric Acid | 1972 |
Effects of xanthine oxidase inhibition in cardiac arrest.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Allopurinol; Animals; Dogs; Heart Arrest; Hypoxia; Purines; Shock, Cardiogenic; Time Factors; Uric Acid; Xanthine Oxidase | 1972 |
The treatment of gout.
Topics: Acute Disease; Allopurinol; Colchicine; Diagnosis, Differential; Female; Gout; Humans; Indomethacin; Male; Metabolic Diseases; Phenylbutazone; Uric Acid | 1972 |
[Combination of allopurinol and benziodarone in prolonged treatment of hyperuricemia due to chronic renal insufficiency].
Topics: Adult; Allopurinol; Analysis of Variance; Benzofurans; Drug Combinations; Female; Humans; Kidney Failure, Chronic; Kidney Function Tests; Liver Function Tests; Male; Middle Aged; Uric Acid; Uricosuric Agents | 1972 |
The management of gout.
Topics: Acute Disease; Allopurinol; Colchicine; Diet Therapy; Gout; Humans; Indomethacin; Phenylbutazone; Purines; Uric Acid; Uricosuric Agents | 1972 |
Effect of allopurinol in renal ischemia.
Topics: Allopurinol; Animals; Aspartate Aminotransferases; Autopsy; Blood Urea Nitrogen; Creatinine; Dogs; Female; Hypoxia; Ischemia; Kidney; L-Lactate Dehydrogenase; Male; Nephrectomy; Radiography; Renal Artery Obstruction; Time Factors; Uric Acid | 1972 |
Medical management of gout.
Topics: Adult; Allopurinol; Colchicine; Diet Therapy; Female; Gout; Humans; Kidney Diseases; Male; Middle Aged; Oxyphenbutazone; Phenylbutazone; Probenecid; Sulfinpyrazone; Uric Acid | 1972 |
Mechanism of allopurinol-mediated increase in enzyme activity in man.
Topics: Allopurinol; Analysis of Variance; Carbon Isotopes; Carboxy-Lyases; Depression, Chemical; Drug Tolerance; Enzyme Activation; Erythrocytes; Gout; Humans; Leukocytes; Models, Biological; Nucleosides; Orotic Acid; Pyrazoles; Pyrimidines; Transferases; Uric Acid | 1972 |
Some genetical aspects of hyperuricaemia and xanthinuria.
Topics: Gout; Humans; Lesch-Nyhan Syndrome; Purine-Pyrimidine Metabolism, Inborn Errors; Sex Factors; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
Correlations of tissue oxypurine levels with xanthine dehydrogenase changes in the chick.
Topics: Allopurinol; Animals; Chickens; Duodenum; Enzyme Induction; Hypoxanthines; Kidney; Liver; Pancreas; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
Studies on the mechanism of fructose-induced hyperuricemia in man.
Topics: Adenine; Adenosine Triphosphate; Aged; Allopurinol; Erythrocytes; Fasting; Fructose; Glucose; Gout; Guanine; Humans; Hypoxanthines; Lactates; Male; Metabolic Clearance Rate; Middle Aged; Pentosyltransferases; Phosphates; Purine Nucleotides; Purines; Ribose; Uric Acid | 1972 |
Nephropathy, xanthinuria, and orotic aciduria complicating Burkitt's lymphoma treated with chemotherapy and allopurinol.
Topics: Allopurinol; Autopsy; Burkitt Lymphoma; Child; Cyclophosphamide; Humans; Kidney; Kidney Diseases; Male; Orotic Acid; Purines; Renal Dialysis; Uric Acid; Xanthines | 1972 |
Clinical features of the Lesch-Nyhan syndrome.
Topics: Adolescent; Allopurinol; Athetosis; Child, Preschool; Humans; Intellectual Disability; Lesch-Nyhan Syndrome; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Sex Chromosomes; Uric Acid | 1972 |
[The use of Allopurinol in the treatment of urinary calculi].
Topics: Allopurinol; Citrates; Humans; Uric Acid; Urinary Calculi; Urography | 1972 |
[Tietze's syndrome--therapeutic trial with allopurinol].
Topics: Adult; Allopurinol; Female; Humans; Male; Middle Aged; Tietze's Syndrome; Uric Acid | 1972 |
Blood glucose levels in dogs pretreated with allopurinol during hemorrhagic shock.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Depression, Chemical; Dogs; Female; Male; Shock, Hemorrhagic; Uric Acid | 1972 |
A direct electrochemical method for the determination of allopurinol and uric acid mixtures.
Topics: Allopurinol; Carbon; Electrochemistry; Electrodes; Methods; Polarography; Uric Acid | 1972 |
Effect of allopurinol on the accumulation of xanthine dehydrogenase in liver and pancreas of chickens after hatching.
Topics: Aging; Allopurinol; Amino Acids; Ammonium Sulfate; Animals; Carbon Isotopes; Chemical Precipitation; Chickens; Enzyme Induction; Enzyme Repression; Hypoxanthines; Liver; Male; Pancreas; Precipitin Tests; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
Xanthine dehydrogenase in hepatopancreas of Helix pomatia (Gastropoda).
Topics: Hypoxanthines; Oxidation-Reduction; Snails; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
Phylogenetic aspects of purine metabolism.
Topics: Allantoin; Ammonia; Amphibians; Animals; Biological Evolution; Birds; Hypoxanthines; Inosine; Invertebrates; Mammals; Nitrogen; Oxygen Consumption; Purines; Reptiles; Urea; Uric Acid; Xanthine Oxidase | 1972 |
N 6 -( 2 -isopentenyl)adenosine metabolism in man.
Topics: Adenosine; Alkenes; Amino Alcohols; Animals; Carbon Isotopes; Chromatography; Chromatography, Ion Exchange; Chromatography, Paper; Humans; Hypoxanthines; Methylation; Milk; Models, Biological; Models, Chemical; Peroxidases; Spectrophotometry; Ultraviolet Rays; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
[Allopurinol induced electrolyte and metabolism changes in the urine of patients with kidney stones].
Topics: Acid-Base Equilibrium; Adult; Allopurinol; Ammonia; Blood Proteins; Calcium; Citrates; Creatinine; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Magnesium; Oxalates; Potassium; Sodium; Statistics as Topic; Uric Acid; Xanthine Oxidase | 1972 |
Uric acid in advanced renal failure.
Topics: Absorption; Adult; Allopurinol; Biological Transport; Chronic Disease; Glomerular Filtration Rate; Humans; Inulin; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Tubules; Middle Aged; Pyrazinamide; Uremia; Uric Acid; Uricosuric Agents | 1972 |
Should asymptomatic hyperuricaemia be treated?
Topics: Allopurinol; Gout; Humans; Kidney Calculi; Metabolic Diseases; Multiphasic Screening; Uric Acid; Uricosuric Agents | 1972 |
Uric acid lithiasis: a report on 3 patients along with a study on the response to 'allopurinol' in one.
Topics: Adult; Allopurinol; Humans; Male; Middle Aged; Uric Acid; Urinary Calculi; Urography | 1971 |
Microscopic studies on skeletal muscle in gout patients treated with allopurinol.
Topics: Adult; Aged; Allopurinol; Biopsy; Birefringence; Female; Freezing; Gout; Histocytochemistry; Humans; Hypoxanthines; Male; Middle Aged; Muscles; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
Uric acid calculi associated with ileostomy for ulcerative colitis.
Topics: Acidosis; Adolescent; Adult; Alkalies; Allopurinol; Child; Colectomy; Colitis, Ulcerative; Dehydration; Female; Humans; Ileostomy; Male; Postoperative Complications; Uric Acid; Urinary Calculi | 1971 |
[Treatment of congenital hyperuricemia].
Topics: Adolescent; Allopurinol; Athetosis; Child; Humans; Hypoxanthines; Intellectual Disability; Lesch-Nyhan Syndrome; Male; Probenecid; Purine-Pyrimidine Metabolism, Inborn Errors; Pyelonephritis; Self Mutilation; Uric Acid; Urinary Calculi; Xanthines | 1971 |
Renal complications in multiple myeloma: pathophysiology and some aspects of clinical management.
Topics: Acidosis, Renal Tubular; Acute Kidney Injury; Aged; Allopurinol; Amyloidosis; Bence Jones Protein; Blood Viscosity; Bone Neoplasms; Diuretics; Humans; Hypercalcemia; Kidney; Kidney Diseases; Middle Aged; Multiple Myeloma; Myeloma Proteins; Pyelonephritis; Uremia; Uric Acid | 1971 |
[Pharmacological studies of diuretics. 4. Changes of serum uric acid level by the succesive administration of thiazide diuretics and other drugs and effects of uricosuric drugs].
Topics: Administration, Oral; Allopurinol; Ammonium Chloride; Animals; Barbiturates; Blood Glucose; Chlorothiazide; Cyclohexanes; Diuretics; Electrolytes; Ethacrynic Acid; Glycine; Hydrochlorothiazide; Hydroflumethiazide; Injections, Subcutaneous; Male; Nucleosides; Phenylbutazone; Probenecid; Quinolines; Rats; Sulfinpyrazone; Sulfonamides; Thiadiazines; Uric Acid; Uricosuric Agents; Xanthenes | 1971 |
[Clinical study of the patients with uric acid stone].
Topics: Carbonates; Humans; Kidney Tubules; Oxalates; Phosphates; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1971 |
Crystals in skeletal muscle.
Topics: Allopurinol; Cold Temperature; Crystallization; Humans; Hypoxanthines; Muscles; Uric Acid; Xanthines | 1971 |
Determination of volatile constituents of human blood and tissue specimens by quantitative high resolution mass spectrometry.
Topics: Allopurinol; Gout; Humans; Hypoxanthines; Mass Spectrometry; Methods; Muscles; Purines; Pyrazoles; Pyrimidines; Spectrum Analysis; Uric Acid; Xanthines | 1971 |
[Xanthinoxidase inhibitors in hyperuricemia and gout].
Topics: Allopurinol; Female; Gout; Humans; Male; Phenylbutazone; Uric Acid | 1971 |
Effect of riboflavin deficiency on the metabolism of oxypurines in chicks.
Topics: Animals; Body Weight; Chickens; Diet; Female; Growth; Hypoxanthines; Kidney; Liver; Male; Organ Size; Paralysis; Purines; Riboflavin Deficiency; Uric Acid; Xanthine Oxidase | 1971 |
Synthesis and oncogenicity of 3-hydroxyuric acid.
Topics: Animals; Benzyl Compounds; Carbon Isotopes; Carcinogens; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Hypoxanthines; Milk; Neoplasms; Nitroso Compounds; Oxidation-Reduction; Rats; Rats, Inbred Strains; Uracil; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
[Diet and pharmacologic therapy of hyperuricemias in the aged].
Topics: Aged; Allopurinol; Benzofurans; Diet Therapy; Gout; Humans; Uric Acid | 1971 |
Influence of oral ribonucleic acid on orotaciduria due to allopurinol administration.
Topics: Administration, Oral; Allopurinol; Diet; Humans; Male; Orotic Acid; RNA; Uric Acid | 1971 |
Reversal of organic brain syndrome with seizures and hyperuricosuria subsequent to allopurinol therapy.
Topics: Allopurinol; Brain Damage, Chronic; Child; Electroencephalography; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Seizures; Uric Acid | 1971 |
pH stat assay for guanine aminohydrolase.
Topics: Aminohydrolases; Animals; Guanine; Hydrogen-Ion Concentration; Kinetics; Liver; Methods; Potentiometry; Rabbits; Spectrophotometry; Ultraviolet Rays; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
[Drug information: a curative for high uric aciduria].
Topics: Allopurinol; Uric Acid | 1969 |
Allopurinol in the prevention of hyperuricemia in Dalmatian dogs.
Topics: Administration, Oral; Allopurinol; Animals; Dog Diseases; Dogs; Uric Acid; Urinary Calculi | 1971 |
Metabolic effects of allopurinol and allo-xanthine.
Topics: Adult; Allopurinol; Drug Tolerance; Enzyme Therapy; Female; Gout; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Multiple Myeloma; Uric Acid; Xanthine Oxidase; Xanthines | 1966 |
Allopurinol in the therapy of neoplasia and blood diseases. Metabolic aspects.
Topics: Allopurinol; Diuresis; Enzyme Therapy; Humans; Hypoxanthines; Leukemia, Lymphoid; Uric Acid; Xanthine Oxidase; Xanthines | 1966 |
Biochemical considerations of the renal damage of gout.
Topics: Allopurinol; Gout; Humans; Hypoxanthines; Kidney Calculi; Leukemia, Lymphoid; Uric Acid; X-Ray Diffraction; Xanthines | 1966 |
Allopurinol in treatment of patients with gout and chronic renal failure.
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Hypoxanthines; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Uric Acid; Xanthines | 1967 |
Prevention and management of acute hyperuricemia in childhood leukemia.
Topics: Acetazolamide; Acute Disease; Adolescent; Allopurinol; Bicarbonates; Blood Urea Nitrogen; Child; Creatinine; Humans; Kidney Diseases; Leukemia, Lymphoid; Leukocyte Count; Male; Mannitol; Prednisone; Renal Dialysis; Uric Acid | 1968 |
Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis.
Topics: Acetazolamide; Acute Kidney Injury; Adult; Allopurinol; Anuria; Bicarbonates; Blood Gas Analysis; Blood Urea Nitrogen; Carbon Dioxide; Cystoscopy; Electroencephalography; Eye Manifestations; Female; Humans; Leukemia, Lymphoid; Leukocytosis; Mannitol; Mercaptopurine; Methotrexate; Peritoneal Dialysis; Prednisone; Splenomegaly; Thrombocytopenia; Uric Acid; Urinary Catheterization; Vincristine; Water-Electrolyte Balance | 1969 |
[Gout in the evolution of Von Gierke's disease].
Topics: Adolescent; Adult; Allopurinol; Child; Female; Glycogen Storage Disease; Glycogen Storage Disease Type I; Gout; Hepatomegaly; Humans; Hyperlipidemias; Joint Diseases; Lactates; Male; Middle Aged; Osteoporosis; Purines; Uric Acid; Uricosuric Agents | 1969 |
Allopurinol in the treatment of gout.
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Sulfinpyrazone; Uric Acid | 1969 |
[Diagnostic value of hyperuricemia].
Topics: Adult; Allopurinol; Child; Diabetes Mellitus; Female; Glycogen Storage Disease; Gout; Humans; Hypertension; Kidney Failure, Chronic; Male; Myxedema; Nutritional Physiological Phenomena; Pre-Eclampsia; Pregnancy; Psoriasis; Purines; Uric Acid; Uricosuric Agents | 1968 |
Hyperuricemic nephropathy. Report of a case of lymphoblastic lymphosarcoma.
Topics: Acetazolamide; Acute Kidney Injury; Allopurinol; Bicarbonates; Biopsy; Child; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Prednisone; Radiography, Thoracic; Thoracic Neoplasms; Uric Acid | 1970 |
Adenosine metabolism in plasma and platelets. IV. Elevated plasmatic adenosine deaminase activity, impaired platelet 14C-adenosine incorporation and hemostatic dysfunction in chronic myeloid leukemia.
Topics: Adenine Nucleotides; Allopurinol; Aminohydrolases; Blood Cell Count; Blood Coagulation Disorders; Blood Platelets; Carbon Isotopes; Chronic Disease; Hemoglobins; Humans; Leukemia, Myeloid; Nucleosides; Uric Acid | 1970 |
[Serum and urine uric acid content in hemoblastoses and gout as well as its modification by allopurinol].
Topics: Allopurinol; Bone Marrow Diseases; Gout; Hodgkin Disease; Humans; Leukemia; Leukemia, Myeloid; Plasmacytoma; Polycythemia Vera; Uric Acid | 1971 |
[Allpurinol in the treatment of hyperuricemia and chronic gout].
Topics: Adult; Aged; Allopurinol; Arthritis; Female; Gout; Humans; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 1969 |
Substrate activation with a xanthine oxidase reaction. An alternative to dismutation as an explanation in the chicken liver system.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Chickens; Enzyme Activation; Hypoxanthines; Liver; Methods; Nitrogen; Oxygen; Partial Pressure; Polarography; Spectrophotometry; Ultraviolet Rays; Uric Acid; Xanthine Oxidase | 1969 |
Suppression of uric acid formation from dietary nucleic acid with allopurinol.
Topics: Allopurinol; Diet; Humans; Male; Purines; RNA; Spectrophotometry; Uric Acid; Yeasts | 1969 |
Nitrogen excretion in the tuatara, Sphenodon punctatus.
Topics: Ammonia; Animal Feed; Animals; Arginase; Creatine; Creatinine; Diet; Dietary Proteins; Growth; Kidney; Ligases; Liver; Nitrogen; Ornithine Carbamoyltransferase; Renal Aminoacidurias; Reptiles; Urea; Uric Acid; Xanthine Oxidase | 1969 |
Xanthinuria with myopathy (with some observations on the renal handling of oxypurines in the disease).
Topics: Adult; Allopurinol; Aminohippuric Acids; Electromyography; Humans; Hypoxanthines; Kidney Function Tests; Male; Metabolism, Inborn Errors; Muscles; Muscular Diseases; Uric Acid; Xanthine Oxidase; Xanthines | 1969 |
[Juvenile hyperuricemia, gout and cerebral palsy (Lesch-Nyhan syndrome)].
Topics: Adolescent; Allopurinol; Athetosis; Cerebral Palsy; Chorea; Gout; Humans; Male; Uric Acid | 1969 |
[Apparently primary kidney disease revealing latent error of purine metabolism in 2 adolescents].
Topics: Adolescent; Adult; Allopurinol; Diet Therapy; Diet, Sodium-Restricted; Diuretics; Gout; Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Glomerulus; Kidney Tubules; Male; Piperazines; Proteinuria; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid | 1969 |
Protein deficiency in spaced-fed rats.
Topics: Allantoin; Animals; Body Weight; DNA; Feeding Behavior; Kidney; Liver; Male; Nitrogen; Organ Size; Phosphates; Protein Deficiency; Rats; RNA; Spleen; Succinate Dehydrogenase; Uric Acid; Vitamin A; Xanthine Oxidase | 1969 |
[Clinical findings and therapy of gout with special reference to the metabolic effects of sulfinpyrazone (Anturan) and allopurinol (Zyloric)].
Topics: Allopurinol; Diabetes Mellitus; Gout; Humans; Hypertension; Kidney Diseases; Male; Sulfinpyrazone; Uric Acid | 1969 |
Allopurinol and urolithiasis.
Topics: Allopurinol; Female; Gout; Humans; Male; Uric Acid; Urinary Calculi | 1969 |
[Xanthine oxidase activity in the jejunal mucosa of patients with gout].
Topics: Gout; Humans; Intestinal Mucosa; Jejunum; Uric Acid; Xanthine Oxidase | 1969 |
[The effect of molybdenum contain in food on certain indices of purine metabolism].
Topics: Animals; Ceruloplasmin; Humans; Liver; Molybdenum; Nutritional Physiological Phenomena; Purines; Rats; Uric Acid; Xanthine Oxidase | 1969 |
[Inhibition of endogenous synthesis of uric acid with allopurinol in patients with gout and urate diathesis].
Topics: Adult; Aged; Allopurinol; Disease Susceptibility; Gout; Humans; Kidney Calculi; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Uric Acid | 1969 |
Allopurinol therapy for renal uric acid calculi.
Topics: Allopurinol; Female; Humans; Kidney Calculi; Middle Aged; Polycythemia Vera; Uric Acid | 1969 |
[A new uricemia-lowering agent: benziodarone. Its use in therapy of urate retention in the course of chronic renal insufficiency].
Topics: Benzofurans; Humans; Kidney Failure, Chronic; Uric Acid; Uricosuric Agents; Vasodilator Agents; Xanthine Oxidase | 1969 |
Depletion of liver adenine nucleotides induced by D-fructose. Dose-dependence and specificity of the fructose effect.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Allantoin; Allopurinol; Animals; Depression, Chemical; Ethanol; Female; Fructose; Galactose; Glucose; Hexoses; In Vitro Techniques; Injections, Intravenous; Kidney; Lactates; Liver; Mannose; Myocardium; Perfusion; Phosphates; Purines; Pyruvates; Rats; Ribose; Sorbitol; Sorbose; Time Factors; Uric Acid | 1969 |
Effects of allopurinol on hyperuricemia secondary to fasting.
Topics: Allopurinol; Drug Tolerance; Fasting; Gout; Humans; Kidney; Uric Acid | 1970 |
Effect of drugs on the binding of urate to human albumin.
Topics: Allopurinol; Aspirin; Colchicine; Humans; Indomethacin; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Sulfinpyrazone; Uric Acid | 1970 |
The treatment of uric acid urolithiasis with particular reference to the southwestern U.S.A.
Topics: Allopurinol; Bicarbonates; Citrates; Humans; United States; Uric Acid; Urinary Calculi | 1970 |
Influence of anoxia and allopurinol on iron metabolism in pregnant rats.
Topics: Allopurinol; Animals; Biological Transport; Blood Volume; Erythrocytes; Female; Hematocrit; Hypoxia; Iron; Iron Isotopes; Liver; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy, Animal; Rats; Uric Acid; Xanthine Oxidase | 1970 |
[Inborn hyperuricemia--an anomaly of uric acid metabolism in connection with psychomotor retardation, involuntary movements and self mutilation, Lesch-Nyhan syndrome].
Topics: Adolescent; Adult; Age Factors; Allopurinol; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Male; Movement Disorders; Psychomotor Disorders; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Sex Factors; Transferases; Uric Acid | 1970 |
Long-term use of allopurinol in the treatment of gout.
Topics: Adolescent; Aged; Allopurinol; Colic; Female; Gout; Humans; Kidney Diseases; Male; Middle Aged; Sulfinpyrazone; Uric Acid | 1970 |
Determination of urinary purines in hyperuricosuric children by thin-layer chromatography.
Topics: Allopurinol; Athetosis; Child; Child, Preschool; Chorea; Chromatography, Thin Layer; Densitometry; Humans; Hypoxanthines; Intellectual Disability; Male; Nucleosides; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Self Mutilation; Uric Acid; Xanthines | 1970 |
Effect of some uricosuric and anti-inflammatory drugs on the binding of uric acid to human serum albumin in vitro.
Topics: Allopurinol; Anti-Inflammatory Agents; Aspirin; Binding Sites; Caprylates; Colchicine; Dialysis; Fluorescence; Humans; In Vitro Techniques; Indomethacin; Mefenamic Acid; Phenylbutazone; Probenecid; Protein Binding; Serum Albumin; Sodium Salicylate; Sulfinpyrazone; Uric Acid; Uricosuric Agents | 1970 |
Effect of allopurinol on iron mobilization.
Topics: Allopurinol; Anemia, Hypochromic; Animals; Diet; Hematocrit; Iron; Liver; Male; Rats; Uric Acid; Xanthine Oxidase | 1970 |
Pathogenesis and medical management of chronic gouty arthritis.
Topics: Allopurinol; Chronic Disease; Colchicine; Gout; Humans; Joints; Kidney; Probenecid; Sulfinpyrazone; Uric Acid | 1970 |
Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency.
Topics: Adult; Allopurinol; Athetosis; Carbon Isotopes; Child; Chorea; Compulsive Behavior; Deficiency Diseases; Glycine; Gout; Guanine; Humans; Hypoxanthines; Inositol; Intellectual Disability; Metabolism, Inborn Errors; Nucleosides; Purines; Self Mutilation; Transferases; Uric Acid | 1970 |
Hyperuricemia complicating acute leukemia. Case reports and comments on therapy.
Topics: Adolescent; Allopurinol; Child; Child, Preschool; Female; Humans; Leukemia; Male; Mercaptopurine; Prednisone; Uric Acid; Vincristine | 1970 |
Diuretics and hyperuricemia.
Topics: Allopurinol; Diuretics; Gout; Humans; Hypertension; Uric Acid; Uricosuric Agents | 1970 |
The significance of the deficiency state in Lesch-Nyhan disease.
Topics: Allopurinol; Amino Acids; Athetosis; Carbon Isotopes; Child, Preschool; Chorea; Compulsive Behavior; Diet Therapy; Glutamates; Glycine; Humans; Infant; Intellectual Disability; Male; Metabolism, Inborn Errors; Movement Disorders; Purines; Self Mutilation; Uric Acid | 1970 |
The influence of adenine on the clinical features and purine metabolism in the Lesch-Nyhan syndrome.
Topics: Adenine; Allopurinol; Athetosis; Bone Marrow; Carbon Isotopes; Child; Child, Preschool; Chorea; Compulsive Behavior; Diet Therapy; Erythrocytes; Folic Acid; Glycine; Humans; Intellectual Disability; Male; Metabolism, Inborn Errors; Movement Disorders; Purines; Self Mutilation; Transferases; Uric Acid; Vitamin B 12 | 1970 |
[Enzymopathic gout. Dyspurinia due to hypoxanthine-guanine-phosphoribosyl-transferase deficiency. Occurrence and clinical characteristics of enzyme repression].
Topics: Adenine; Adult; Age Factors; Allopurinol; Enzyme Repression; Female; Gout; Guanine; Humans; Hypoxanthines; Kidney Calculi; Kidney Diseases; Male; Pedigree; Transferases; Uric Acid; Xanthines | 1970 |
Allopurinol: alteration in pyrimidine metabolism in man.
Topics: Allopurinol; Carboxy-Lyases; Depression, Chemical; Erythrocytes; Gout; Humans; Hypoxanthines; Kinetics; Nucleosides; Nucleotides; Orotic Acid; Pyrimidines; Uric Acid; Xanthine Oxidase; Xanthines | 1970 |
[Formation of urinary calculi and uric acid findings in children with leukemia].
Topics: Allopurinol; Child; Child, Preschool; Female; Humans; Leukemia; Male; Purines; Uric Acid; Urinary Calculi | 1970 |
The function of subcellular fractions in the oxidation of glutathione in rat liver homogenate.
Topics: Animals; Dialysis; Glutathione; Hypoxanthines; In Vitro Techniques; Liver; Microsomes, Liver; Oxidation-Reduction; Peroxidases; Proteins; Rats; Tissue Extracts; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1970 |
Hypertension, hyperuricemia and iatrogenic disease.
Topics: Aged; Allopurinol; Aortic Diseases; Arteriosclerosis; Brain; Catheterization; Chlorothiazide; Diagnosis, Differential; Endocarditis, Bacterial; Female; Heart Failure; Humans; Hypertension; Iatrogenic Disease; Intracranial Aneurysm; Kanamycin; Kidney; Liver; Nephrosclerosis; Sepsis; Staphylococcal Infections; Thromboembolism; Uric Acid | 1970 |
A method for determining plasma levels of oxypurines.
Topics: Carbon Isotopes; Chromatography, Gel; Chromatography, Ion Exchange; Female; Humans; Hypoxanthines; Male; Methods; Spectrophotometry; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1970 |
[Treatment of gout].
Topics: Allopurinol; Analgesics; Gout; Humans; Uric Acid; Uricosuric Agents | 1970 |
[Therapeutic agents for gout effecting the kidney].
Topics: Allopurinol; Gout; Humans; Kidney; Phenylbutazone; Uric Acid; Uricosuric Agents | 1970 |
[Will the gout be eliminated?].
Topics: Allopurinol; Gout; Humans; Uric Acid; Uricosuric Agents | 1970 |
Xanthine nephropathy in a patient with lymphosarcoma treated with allopurinol.
Topics: Adult; Allopurinol; Autopsy; Cyclophosphamide; Humans; Kidney Calculi; Kidney Pelvis; Lymphoma, Non-Hodgkin; Male; Prednisone; Uric Acid; Vincristine; Xanthine Oxidase; Xanthines | 1970 |
Allopurinol and xanthine nephropathy.
Topics: Adult; Allopurinol; Child; Humans; Kidney Calculi; Lymphoma, Non-Hodgkin; Male; Uric Acid; Xanthine Oxidase; Xanthines | 1970 |
The influence of allopurinol on the course of gout. A study of 28 cases.
Topics: Age Factors; Allopurinol; Colchicine; Drug Synergism; Gout; Humans; Probenecid; Uric Acid | 1970 |
[Severe metabolic acidosis in a diabetic during treatment with phenformin and allopurinol. A result of drug interaction?].
Topics: Acidosis; Aged; Allopurinol; Diabetes Complications; Diabetes Mellitus; Diabetic Nephropathies; Female; Humans; Phenformin; Uric Acid | 1970 |
The importance of renal damage due to hyperuricaemia and its prevention by allopurinol.
Topics: Allopurinol; Humans; Kidney; Kidney Calculi; Kidney Diseases; Uric Acid | 1970 |
[Diagnosis and therapy of uric arthritis].
Topics: Acute Disease; Adult; Allopurinol; Anti-Inflammatory Agents; Chronic Disease; Diagnosis, Differential; Diet Therapy; Female; Gout; Humans; Male; Middle Aged; Purines; Uric Acid; Uricosuric Agents | 1970 |
Preliminary results from high-resolution analyses of ultraviolet-absorbing and carbohydrate constituents in several pathologic body fluids.
Topics: Adolescent; Adult; Alkaptonuria; Allopurinol; Amniotic Fluid; Athetosis; Carbohydrates; Chorea; Chromatography, Ion Exchange; Compulsive Behavior; Female; Gout; Humans; Hypertension; Infant; Infant, Newborn; Intellectual Disability; Male; Maple Syrup Urine Disease; Methods; Middle Aged; Nephritis; Nicotinic Acids; Phenols; Pregnancy; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Self Mutilation; Spectrophotometry; Sulfuric Acids; Ultraviolet Rays; Uric Acid; Xanthines | 1970 |
Effect of dietary purine restriction, allupurinol, and oxipurinol on urinary excretion of ultraviolet-absorbing compounds.
Topics: Adenine; Allopurinol; Chromatography, Ion Exchange; Diet; Humans; Hypoxanthines; Orotic Acid; Purines; Pyrimidines; Spectrophotometry; Ultraviolet Rays; Uric Acid; Uridine; Xanthine Oxidase | 1970 |
Comparative studies on liver and kidney xanthine dehydrogenase in two breeds of domestic chicks (Gallus domesticus) during prolonged starvation.
Topics: Acetates; Animals; Breeding; Chickens; Dietary Proteins; Hematocrit; Kidney; Liver; Organ Size; Quaternary Ammonium Compounds; Species Specificity; Starvation; Uric Acid; Xanthine Oxidase | 1970 |
Uric acid metabolism in starvation.
Topics: Allopurinol; Female; Gout; Humans; Male; Obesity; Starvation; Uric Acid | 1970 |
Medical therapy of renal calculi.
Topics: Allopurinol; Calcium; Creatinine; Cystinuria; Diuresis; Humans; Kidney; Kidney Calculi; Magnesium; Metabolic Diseases; Methylene Blue; Oxalates; Penicillamine; Phosphates; Uric Acid; Urinary Tract Infections; Urine; Water-Electrolyte Balance | 1970 |
The effect of allopurinol on the excretion of oxypurines by the chick.
Topics: Allopurinol; Animals; Chickens; Feces; Hypoxanthines; Male; Metabolism; Uric Acid; Xanthines | 1970 |
Cystinuria, hyperuricemia and uric acid nephrolithiasis. Case report.
Topics: Adult; Allopurinol; Cystine; Cystinuria; Female; Glycine; Humans; Kidney Calculi; Penicillamine; Uric Acid; Urine | 1970 |
A method for the determination of plasma guanase on finger-tip blood.
Topics: Aminohydrolases; Drug Stability; Erythrocytes; Fingers; Guanine; Hepatitis A; Humans; Kidney Diseases; Spectrophotometry; Uric Acid; Xanthine Oxidase | 1970 |
Partial deficiency of hypoxanthine-guanine phosphoribosyltransferase associated with gout and uric acid lithiasis.
Topics: Adult; Aged; Allopurinol; Calculi; Erythrocytes; Genes, Recessive; Gout; Guanine; Heterozygote; Humans; Hypoxanthines; Male; Metabolism, Inborn Errors; Methods; Middle Aged; Pedigree; Sex Chromosomes; Transferases; Uric Acid | 1970 |
[Allopurinol in the treatment of gout].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Probenecid; Uric Acid | 1970 |
[Effect of colchicine and allopurinol on uricogenesis. II. Effect of administration to chicks and mice].
Topics: Adenine; Allopurinol; Animals; Chickens; Colchicine; Colorimetry; Dialysis; Hypoxanthines; Injections, Intraperitoneal; Kidney; Liver; Mice; Nucleosides; Spectrophotometry; Uric Acid; Xanthine Oxidase | 1970 |
[Effect of allopurinol (Zyloric) on uric acid, creatinine, fasting blood sugar and plasma lipids in patients with gout].
Topics: Adult; Allopurinol; Blood Glucose; Cholesterol; Creatinine; Fasting; Fatty Acids, Nonesterified; Gout; Humans; Lipids; Male; Middle Aged; Phospholipids; Triglycerides; Uric Acid | 1970 |
Lesch-Nyhan syndrome.
Topics: Allopurinol; Athetosis; Benzofurans; Brain; Child; Child, Preschool; Chorea; Compulsive Behavior; Erythrocytes; Female; Guanine; Humans; Hypoxanthines; Infant; Intellectual Disability; Japan; Kidney; Lesch-Nyhan Syndrome; Liver; Male; Proteinuria; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Transferases; Uric Acid | 1970 |
[Oxalic lithiasis and disorder of uric acid metabolism].
Topics: Adult; Allopurinol; Humans; Kidney Calculi; Male; Middle Aged; Oxalates; Pedigree; Sex Factors; Uric Acid | 1970 |
Experimental study on certain methods of decreasing the urinary excretion of uric acid.
Topics: Allopurinol; Animals; Antibody Formation; Antigen-Antibody Complex; Catalysis; Disease Models, Animal; Dogs; Enzyme Activation; Enzyme Repression; Female; Immunization; Oxidation-Reduction; Tungsten; Uric Acid; Uricosuric Agents; Xanthine Oxidase; Xanthines | 1970 |
[Inhibition of endogenous uric acid synthesis with allopurinol in gout and urate diathesis. Remarks on E. Holländer and P. Schwarczmann, Münch. Med. Wschr. 3 (1969) 32, 1623-1626].
Topics: Allopurinol; Gout; Humans; Purine-Pyrimidine Metabolism, Inborn Errors; Urate Oxidase; Uric Acid | 1970 |
Clinical and therapeutic aspects of the Lesch-Nyhan syndrome in Japanese children.
Topics: Allopurinol; Athetosis; Azathioprine; Benzofurans; Child; Child, Preschool; Guanine; Humans; Hypoxanthines; Intellectual Disability; Japan; Ketones; Lesch-Nyhan Syndrome; Male; Paraplegia; Pentosyltransferases; Phenols; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Spasm; Uric Acid; Xanthines | 1970 |
Xanthinuria: an additional case with demonstration of xanthine oxidase deficiency.
Topics: Adult; Biopsy; Female; Humans; Hypoxanthines; Intestinal Mucosa; Jejunum; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Spectrophotometry; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
The antinociceptive and anti-exudative action of a xanthine oxidase inhibitor (allopurinol) and of xanthine.
Topics: Allopurinol; Animals; Arachidonic Acids; Coloring Agents; Hypoxanthines; Mice; Movement; Quinones; Uric Acid; Xanthines | 1971 |
[Acute kidney failure and hyperuricemia].
Topics: Acidosis, Respiratory; Acute Kidney Injury; Allopurinol; Animals; Anuria; Dogs; Gout; Humans; Hypoxanthines; Hypoxia; Shock, Hemorrhagic; Uric Acid | 1971 |
A quantitative study of skeletal-muscle purines and pyrazolo(3,4-d)pyrimidines in gout patients treated with allopurinol.
Topics: Allopurinol; Biopsy; Gout; Humans; Hypoxanthines; Mass Spectrometry; Muscles; Purines; Pyrazoles; Pyrimidines; Uric Acid; Xanthine Oxidase; Xanthines | 1971 |
Hyperlipoproteinaemia in gout.
Topics: Adult; Aged; Allopurinol; Blood Protein Disorders; Blood Protein Electrophoresis; Cholesterol; Gout; Humans; Hyperlipidemias; Lipoproteins; Male; Middle Aged; Probenecid; Prognosis; Triglycerides; Uric Acid | 1971 |
Xanthine oxidase-mediated oxidation of epinephrine.
Topics: Adrenochrome; Allopurinol; Animals; Catalase; Cattle; Chromatography, Paper; Epinephrine; Female; Fluorescence; Hypoxanthines; Milk; Oxidation-Reduction; Pteridines; Spectrophotometry; Time Factors; Uric Acid; Xanthine Oxidase | 1971 |
The genetic control of xanthine dehydrogenase and urate oxidase synthess in Aspergillus nidulans.
Topics: Aspergillus; Enzyme Induction; Genetics, Microbial; Mutation; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1967 |
Prophylaxis of idiopathic and gouty uric acid lithiasis by allopurinol.
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Hyperparathyroidism; Kidney Tubules; Male; Middle Aged; Uric Acid; Uricosuric Agents; Urinary Calculi | 1967 |
[Allopurinol].
Topics: Allopurinol; Gout; Humans; Kidney Diseases; Uric Acid; Xanthine Oxidase | 1967 |
[Hyperuricemia. IX. Complications of hyperuricemia. On the treatment of hyperuricemia].
Topics: Allopurinol; Gout; Humans; Joint Diseases; Kidney Calculi; Orotic Acid; Time Factors; Uric Acid; Urinary Calculi | 1967 |
[Allopurinol in hyperuricemia].
Topics: Allopurinol; Gout; Humans; Male; Methods; Uric Acid | 1967 |
[Treatment of the gouty diathesis with a xanthine oxidase inhibitor. A clinical trial of allopurinol].
Topics: Aged; Allopurinol; Drug Synergism; Gout; Humans; Male; Middle Aged; Phenylbutazone; Sulfinpyrazone; Uric Acid | 1967 |
[On the formation of uric acid by hepatic xanthinedehydrogenase].
Topics: Adenine; Animals; Chickens; Liver; Uric Acid; Xanthine Oxidase | 1967 |
[Effects of allopurinol on plasma lipid fractions in gout patients].
Topics: Adult; Aged; Allopurinol; Gout; Humans; Lipids; Male; Middle Aged; Uric Acid | 1967 |
[Hypouricemizing effect of benzbromarone. Study of 24 cases (preliminary results)].
Topics: Adult; Aged; Allopurinol; Benzofurans; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1967 |
[Treatment of hyperuricemia].
Topics: Allopurinol; Gout; Humans; Male; Middle Aged; Uric Acid | 1967 |
[Familial xanthinuria].
Topics: Adolescent; Animals; Female; Humans; Male; Metabolism, Inborn Errors; Rats; Uric Acid; Urinary Calculi; Xanthine Oxidase; Xanthines | 1967 |
Hyperuricemia in neoplastic disease in children: prevention with allopurinol, a xanthine oxidase inhibitor.
Topics: Adolescent; Allopurinol; Blood Urea Nitrogen; Child; Child, Preschool; Female; Humans; Leukocyte Count; Male; Metabolic Diseases; Neoplasms; Purines; Uric Acid; Xanthine Oxidase | 1968 |
An enzymatic basis for variation in response to allopurinol. Hypoxanthine-guanine phosphoribosyltransferase deficiency.
Topics: Adenine; Adolescent; Adult; Aged; Allopurinol; Child; Creatinine; Glucosyltransferases; Gout; Guanine; Humans; Hypoxanthines; Male; Metabolism, Inborn Errors; Middle Aged; Purines; Uric Acid; Xanthines | 1968 |
Regulation of uric acid formation.
Topics: Allopurinol; Glucosyltransferases; Gout; Humans; Hypoxanthines; Purines; Uric Acid; Xanthine Oxidase; Xanthines | 1968 |
The effect of allopurinol on urate oxidase activity.
Topics: Allopurinol; Animals; Cattle; Urate Oxidase; Uric Acid | 1968 |
Purine metabolism in the chick embryo; effects of uricogenesis and xanthine oxidase inhibition.
Topics: Adenine; Amines; Animals; Carbon Isotopes; Chick Embryo; Formates; Glycine; Guanine; Nucleic Acids; Nucleotides; Purines; Pyrazoles; Pyrimidines; Thiazoles; Uric Acid; Xanthine Oxidase | 1968 |
Activation of liver tryptophan oxygenase by adenosine 3',5'-phosphate and by other purine derivatives.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Allopurinol; Animals; Catalase; Hemoglobins; Hydrogen Peroxide; Hypoxanthines; Liver; Male; Nitrogen; Oxygen; Rats; Theophylline; Tryptophan Oxygenase; Uric Acid; Xanthine Oxidase | 1968 |
Basic sciences in medicine: the example of gout.
Topics: Allopurinol; Colchicine; Female; Gout; Humans; Male; Metabolism, Inborn Errors; Purines; Sex Factors; Uric Acid; Xanthine Oxidase | 1968 |
Long-term treatment of gout with "allopurinol".
Topics: Allopurinol; Chronic Disease; Colchicine; Colorimetry; Female; Gout; Humans; Male; Purines; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1968 |
Study of purine metabolism in a xanthinuric female.
Topics: Arthritis; Carbon Isotopes; Creatinine; Female; Guanine; Humans; Hypoxanthines; Metabolism, Inborn Errors; Middle Aged; Psoriasis; Purines; RNA; Spectrophotometry; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1968 |
Enzyme activities in tissues of zinc-deficient rats.
Topics: Alanine Transaminase; Alcohol Oxidoreductases; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Catalase; Deficiency Diseases; Glutamate Dehydrogenase; Intestinal Mucosa; Kidney; Liver; Rats; Uric Acid; Xanthine Oxidase; Zinc | 1968 |
Renal clearance of oxipurinol, the chief metabolite of allopurinol.
Topics: Allopurinol; Animals; Dogs; Gout; Humans; Kidney; Kidney Function Tests; Probenecid; Spectrophotometry; Uric Acid | 1968 |
Lesch-Nyhan syndrome treated from the early neonatal period.
Topics: Allopurinol; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Metabolism, Inborn Errors; Muscle Cramp; Self Mutilation; Uric Acid | 1968 |
X-linked primary hyperuricaemia (hypoxanthine-guanine phosphoribosyltransferase deficiency encephalopathy.
Topics: Allopurinol; Athetosis; Child; Genes, Recessive; Guanine Nucleotides; Humans; Hypoxanthines; Intellectual Disability; Locomotion; Male; Neurologic Manifestations; Posture; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Sex Chromosomes; Speech Disorders; Transferases; Uric Acid | 1968 |
[Early diagnosis and early treatment of gout].
Topics: Adult; Allopurinol; Colchicine; Diagnosis, Differential; Female; Gout; Humans; Male; Middle Aged; Uric Acid; Uricosuric Agents | 1968 |
Etiology and treatment of gout--modern concepts.
Topics: Allopurinol; Colchicine; Crystallization; Diagnosis, Differential; Diet Therapy; Gout; Humans; Indomethacin; Joint Diseases; Kidney Diseases; Kidneys, Artificial; Phenylbutazone; Probenecid; Proteinuria; Purines; Radiography; Salicylates; Steroids; Sulfinpyrazone; Uric Acid | 1968 |
Allopurinol and iron metabolism in man.
Topics: Alkaline Phosphatase; Allopurinol; Arthritis, Rheumatoid; Blood Cell Count; Blood Protein Electrophoresis; Bone Marrow Examination; Creatinine; Erythrocytes; Feces; Gout; Humans; Iron; Iron Isotopes; Liver; Radiography; Sacrum; Spleen; Transaminases; Uric Acid | 1968 |
Secretion of purines by the small intestine: general characteristics.
Topics: Adenine; Allopurinol; Animals; Biological Transport; Caffeine; Carbon Isotopes; Chromatography, Paper; Cricetinae; Female; Hypoxanthines; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Methods; Nucleotides; Purines; Pyrimidines; Tritium; Uric Acid; Xanthine Oxidase | 1968 |
C14 studies of uric acid turnover.
Topics: Acute Kidney Injury; Allopurinol; Carbon Isotopes; Gout; Humans; Mathematics; Uric Acid | 1968 |
The induction and repression of the enzymes of purine breakdown in Aspergillus nidulans.
Topics: Allantoin; Amidohydrolases; Aspergillus; Cell-Free System; Depression, Chemical; Enzyme Induction; Enzyme Repression; Genetics, Microbial; Hypoxanthines; Mutation; Purines; Quaternary Ammonium Compounds; Urate Oxidase; Urea; Urease; Ureohydrolases; Uric Acid; Xanthine Oxidase | 1968 |
A short trial assessment of uricosuric therapy in gout.
Topics: Adult; Aged; Allopurinol; Female; Glomerular Filtration Rate; Gout; Humans; Male; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid | 1968 |
[Allopurinol in the treatment of gout: initial results].
Topics: Adult; Aged; Allopurinol; Female; Gastrointestinal Diseases; Gout; Humans; Kidney Failure, Chronic; Male; Middle Aged; Skin Diseases; Uric Acid | 1968 |
[Gout and development of urate calculi in the urinary tract].
Topics: Allopurinol; Citrus; Flavonoids; Gout; Humans; Male; Middle Aged; Piperazines; Purines; Uric Acid; Urinary Calculi | 1968 |
[Allopurinol in the treatment of gout].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1968 |
[Allopurinol in the treatment of gout].
Topics: Adult; Allopurinol; Gout; Humans; Indomethacin; Male; Middle Aged; Probenecid; Uric Acid | 1968 |
[Therapy of gout in surgical patients].
Topics: Achilles Tendon; Allopurinol; Cortisone; Diagnosis, Differential; Gout; Humans; Joint Diseases; Male; Middle Aged; Probenecid; Surgical Procedures, Operative; Tendinopathy; Uric Acid | 1968 |
[The inhibition of uric acid synthesis with Allopurinol].
Topics: Adult; Aged; Allopurinol; Arthritis, Rheumatoid; Female; Gout; Humans; Kidney Calculi; Male; Middle Aged; Uric Acid | 1968 |
A comparative study of the xanthine oxidase inhibitors allopurinol and oxipurinol in man.
Topics: Adult; Aged; Allopurinol; Gout; Humans; Hypoxanthines; Male; Middle Aged; Purines; Pyrazoles; Pyrimidines; Uric Acid; Xanthine Oxidase; Xanthines | 1968 |
[Use of penicillamine and allopurinol in the treatment of urinary lithiasis due to cystinuria and hyperuricemia].
Topics: Adult; Allopurinol; Child, Preschool; Cystinuria; Female; Humans; Penicillamine; Uric Acid; Urinary Calculi | 1968 |
[Therapy of hyperuricemia with allopurinol].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Kidney Diseases; Kidney Function Tests; Male; Methods; Middle Aged; Time Factors; Uric Acid | 1968 |
[Congenital hyperuricemia with neurologic disorders].
Topics: Allopurinol; Guanine; Humans; Hypoxanthines; Intellectual Disability; Kidney Diseases; Metabolism, Inborn Errors; Nervous System Diseases; Sex Chromosomes; Transferases; Uremia; Uric Acid; Xanthine Oxidase | 1968 |
Allopurinol and the control of hyperuricemia in neoplastic disease.
Topics: Allopurinol; Humans; Leukemia; Mercaptopurine; Uric Acid | 1968 |
[Allopurinol: its clinical use].
Topics: Adult; Aged; Allopurinol; Child; Diuretics; Female; Gout; Humans; Kidney Diseases; Kidney Failure, Chronic; Leukemia; Male; Metabolic Clearance Rate; Middle Aged; Myeloproliferative Disorders; Uremia; Uric Acid | 1968 |
[Prolonged allopurinol therapy in chronic renal insufficiency].
Topics: Adult; Aged; Allopurinol; Creatinine; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitrogen; Uric Acid | 1968 |
[Allopurinol in the treatment of hyperuricemia and chronic gout].
Topics: Adult; Aged; Allopurinol; Arthritis; Female; Gout; Humans; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 1968 |
[Uric acid and its metabolism].
Topics: Allopurinol; Female; Glomerular Filtration Rate; Glutamine; Gout; Humans; Kidney Tubules; Male; Purines; Urate Oxidase; Uric Acid; Uricosuric Agents | 1968 |
[Modalities of purine excretion during enzyme treatment of gout and other hyperuricemic conditions with urate oxidase].
Topics: Aged; Allantoin; Antigen-Antibody Reactions; Complement Fixation Tests; Female; Gout; Humans; Immunization; Male; Oxidoreductases; Purines; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1968 |
[Treatment of gouty purine metabolism disorder with mercapto-pyrazolo-pyrimidine (thiopurinol)].
Topics: Allopurinol; Calculi; Drug Tolerance; Female; Gout; Guanine Nucleotides; Humans; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidines; Transferases; Uric Acid; Uricosuric Agents; Xanthine Oxidase; Xanthines | 1968 |
[Encephalopathy with disorders of purine metabolism. Familial case].
Topics: Adenosine Triphosphate; Allopurinol; Anemia; Brain Diseases; Carbon Isotopes; Child, Preschool; Erythrocytes; Fibroblasts; Humans; Infant; Intellectual Disability; Kidney Diseases; Male; Metabolism, Inborn Errors; Purines; Self Mutilation; Transferases; Uric Acid | 1968 |
[Gout (pathogenesis and therapy)].
Topics: Allopurinol; Colchicine; Diet Therapy; Gout; Humans; Indomethacin; Phenylbutazone; Uric Acid; Uricosuric Agents | 1968 |
[Effects of xanthine oxidase inhibitor, 4-hydroxypyrazolo-(3, 4-d)-pyrimidine (zyloric) on the nucleic acid metabolism and its pharmacological actions. 1].
Topics: Allantoin; Allopurinol; Animals; Cardiovascular System; Cats; Female; Intestine, Small; Male; Mice; Nucleic Acids; Rabbits; Respiration; Sleep; Uric Acid; Xanthine Oxidase; Xanthines | 1968 |
[Gout in advanced age].
Topics: Age Factors; Aged; Allopurinol; Bone and Bones; Cardiovascular Diseases; Colchicine; Female; Gout; Humans; Hyperlipidemias; Hypertension; Kidney Diseases; Male; Probenecid; Sodium; Sulfinpyrazone; Uric Acid | 1968 |
Treatment of gout and urate calculi with allopurinol.
Topics: Allopurinol; Colchicine; Follow-Up Studies; Gout; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Uric Acid; Urinary Calculi | 1968 |
[Experimental studies of fructose overloading in normal subjects and in patients with gout].
Topics: Adult; Fructose; Gout; Humans; Liver; Male; Nucleoproteins; Proteins; Purines; Uric Acid; Xanthine Oxidase | 1968 |
Urinary xanthine stones--a rare complication of allopurinol therapy.
Topics: Adolescent; Allopurinol; Chromatography; Depression, Chemical; Erythrocytes; Fibroblasts; Humans; Leukocytes; Male; Psychomotor Disorders; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Transferases; Uric Acid; Urinary Bladder Calculi; Urinary Calculi; Xanthines | 1969 |
Congenital hyperuricemia. An inborn error of purine metabolism associated with psychomotor retardation, athetosis, and self-mutilation.
Topics: Adenine; Allopurinol; Athetosis; Child, Preschool; Diet Therapy; Genes, Recessive; Humans; Male; Metabolism, Inborn Errors; Nucleotides; Psychomotor Disorders; Purines; Self Mutilation; Sex Chromosomes; Transferases; Uric Acid | 1969 |
Bilateral ureteral obstruction after the administration of allopurinol to a patient with renal pelvic urate calculi.
Topics: Allopurinol; Colchicine; Creatinine; Gout; Humans; Kidney Calculi; Male; Middle Aged; Phenylbutazone; Sulfadiazine; Ureteral Obstruction; Uric Acid; Urography | 1969 |
Purines: active transport by isolated choroid plexus.
Topics: Adenine; Allopurinol; Animals; Biological Transport, Active; Blood-Brain Barrier; Choroid Plexus; Female; Guanine; Hypoxanthines; In Vitro Techniques; Kinetics; Purines; Rabbits; Uracil; Uric Acid; Xanthines | 1969 |
Cardiac and skeletal muscle metabolic energy stores in hemorrhagic shock.
Topics: Adenosine Triphosphate; Allopurinol; Animals; Arteries; Blood Pressure; Cats; Dogs; Glycogen; Heart Rate; Muscles; Myocardium; Phosphocreatine; Shock, Hemorrhagic; Uric Acid; Veins | 1969 |
Liver xanthine oxidase in gouty patients.
Topics: Adult; Aged; Biopsy; Female; Gout; Humans; Liver; Liver Function Tests; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 1969 |
[Conservative treatment of kidney calculi].
Topics: Allopurinol; Calcium; Calcium Phosphates; Chemical Phenomena; Chemistry; Citrates; Cystine; Diagnosis, Differential; Diet Therapy; Humans; Kidney Calculi; Magnesium; Oxalates; Penicillamine; Phosphates; Quaternary Ammonium Compounds; Uric Acid; Xanthines | 1969 |
Uricase inhibition in the rat by s-triazines: an animal model for hyperuricemia and hyperuricosuria.
Topics: Allantoin; Animals; Hydantoins; Injections, Intraperitoneal; Male; Models, Biological; Rats; Triazines; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1969 |
The use of allopurinol in controlling hyperuricemia.
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Male; Middle Aged; Uric Acid | 1969 |
Effect of allopurinol on hemorrhagic shock.
Topics: Allopurinol; Animals; Blood Pressure; Dogs; Hypoxanthines; Methods; Oxygen Consumption; Purines; Shock, Hemorrhagic; Uric Acid; Xanthine Oxidase | 1969 |
Uricemia and urolithiasis.
Topics: Allopurinol; Apatites; Calcium; Creatinine; Female; Humans; Hyperparathyroidism; Male; Sex Factors; Uric Acid; Urinary Calculi | 1969 |
Uric acid renal lithiasis: management by allopurinol.
Topics: Adult; Allopurinol; Gout; Humans; Kidney Calculi; Male; Middle Aged; Uric Acid | 1969 |
A new disorder of purine metabolism with behavioral manifestations.
Topics: Adenine; Allopurinol; Autistic Disorder; Carbon Isotopes; Child Behavior Disorders; Child, Preschool; Erythrocytes; Glucosyltransferases; Glycine; Gout; Guanine; Humans; Hypoxanthines; Intellectual Disability; Male; Mutism; Nucleotides; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Xanthenes | 1969 |
Dietary-induced depletion and repletion of avian liver xanthine dehydrogenase.
Topics: Animals; Body Weight; Chickens; Diet; Dietary Proteins; Liver; Nitrogen; Organ Size; Spectrophotometry; Uric Acid; Xanthine Oxidase | 1969 |
[Acute kidney failure in hemoblastosis with peritoneal dialysis].
Topics: Acute Kidney Injury; Allopurinol; Blood Cell Count; Child; Electrocardiography; Humans; Leukemia; Male; Peritoneal Dialysis; Uric Acid | 1969 |
Degradation of xanthine by Penicillium chrysogenum.
Topics: Adenine; Allantoin; Amidohydrolases; Hypoxanthines; Penicillium; Urate Oxidase; Ureohydrolases; Uric Acid; Xanthine Oxidase; Xanthines | 1969 |
Studies of uric acid pool size and turnover rate.
Topics: Adolescent; Adult; Aged; Allopurinol; Carbon Isotopes; Female; Gout; Humans; Hypertension; Male; Mathematics; Metabolic Clearance Rate; Middle Aged; Uric Acid | 1969 |
6-thiopurines as substrates and inhibitors of purine oxidases: a pathway for conversion of azathioprine into 6-thiouric acid without release of 6-mercaptopurine.
Topics: Alkanes; Animals; Azathioprine; Cattle; Chemical Phenomena; Chemistry; Glutathione; Humans; Liver; Mercaptopurine; Milk; Oxidoreductases; Rabbits; Uric Acid; Xanthine Oxidase | 1969 |
Purine N-oxides. XXX. Biochemical studies of the oncogen 3-hydroxyxanthine.
Topics: Allantoin; Allopurinol; Animals; Carbon Isotopes; Carcinogens; Chromatography, Ion Exchange; Connective Tissue; Culture Techniques; Cyclic N-Oxides; Depression, Chemical; Female; Liver; Uric Acid; Xanthine Oxidase; Xanthines | 1969 |
[The uric acid calculi as complication of leukosis].
Topics: Aged; Allopurinol; Antineoplastic Agents; Humans; Leukemia, Lymphoid; Tablets; Uric Acid; Urinary Calculi | 1969 |
Management of gout.
Topics: Acute Disease; Allopurinol; Chronic Disease; Colchicine; Gout; Humans; Indomethacin; Metabolic Diseases; Phenylbutazone; Salicylates; Uric Acid; Uricosuric Agents | 1969 |
[Changes in the serum concentration of uric acid under the effect of benzbromaronum].
Topics: Adult; Allopurinol; Benzofurans; Depression, Chemical; Female; Gout; Humans; Male; Middle Aged; Uric Acid; Uricosuric Agents | 1969 |
Reassessment of alkaline proteases and the presence of xanthine oxidase in mouse muscle.
Topics: Animals; Centrifugation; Cyanides; Dialysis; Hot Temperature; Hydrogen-Ion Concentration; Hypoxanthines; Indicators and Reagents; Mice; Muscles; Nucleosides; Nucleotides; Peptide Hydrolases; Phenols; Spectrophotometry; Spectrum Analysis; Uric Acid; Xanthine Oxidase; Xanthines | 1969 |
Biochemical and genetical studies of purine breakdown in Aspergillus.
Topics: Allantoin; Ammonia; Aspergillus; Culture Media; Hypoxanthines; In Vitro Techniques; Mutation; Purines; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1965 |
Inhibition of uric acid biosynthesis in the chick embryo and chicken by a xanthine oxidase inhibitor, 4-hydroxypyrazolo(3,4d)pyrimidine.
Topics: Animals; Chick Embryo; Enzymes; Hypoxanthines; Poultry; Uric Acid; Xanthine Oxidase | 1965 |
Xanthine oxidase inhibition in the management of hyperuricemia in leukemias and lymphomas.
Topics: Blood; Enzyme Therapy; Humans; Leukemia; Lymphoma; Uric Acid; Xanthine Oxidase | 1965 |
Allopurinal and acute uric acid nephropathy.
Topics: Adolescent; Aged; Enzyme Therapy; Humans; Kidney Diseases; Leukemia; Male; Purines; Pyrazoles; Pyrimidines; Uric Acid; Xanthine Oxidase | 1966 |
Use of allopurinol for prevention and control of hyperuricemia in patients with neoplastic disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Blood; Bone Marrow Diseases; Child, Preschool; Colonic Neoplasms; Enzyme Therapy; Female; Humans; Leukemia; Lymphoma; Male; Middle Aged; Mycosis Fungoides; Polycythemia Vera; Pyrimidines; Sarcoma; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1966 |
Allopurinol in the management of gout.
Topics: Adult; Enzyme Therapy; Female; Gout; Humans; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 1966 |
The treatment of gout and disorders of uric acid metabolism with allopurinol.
Topics: Aged; Colchicine; Diet; Enzyme Therapy; Female; Gout; Humans; Male; Middle Aged; Sulfinpyrazone; Uric Acid; Urinary Calculi; Urobilin; Xanthine Oxidase | 1966 |
Use of allopurinol in preventing hyperuricemia in leukemia and lymphoma.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Enzyme Therapy; Female; Gout; Humans; Kidney Diseases; Leukemia; Lymphoma; Male; Middle Aged; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1966 |
Allopurinol in the treatment of hyperuricemia and gout.
Topics: Adult; Blood; Child; Child, Preschool; Enzyme Therapy; Gout; Humans; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 1966 |
Uric acid production with particular reference to the role of xanthine oxidase and its inhibition.
Topics: Enzymes; Gout; Humans; Pyrimidines; Uric Acid; Xanthine Oxidase | 1966 |
The pharmaceutical treatment of gout.
Topics: Enzyme Therapy; Gout; Humans; Indomethacin; Phenylbutazone; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Effects of allopurinol, a xanthine oxidase inhibitor, and sulfinpyrazone upon the urinary and serum urate concentrations in eight patients with tophaceous gout.
Topics: Aged; Blood; Drug Synergism; Enzyme Therapy; Gout; Humans; Middle Aged; Pyrimidines; Sulfinpyrazone; Uric Acid; Urine; Xanthine Oxidase | 1966 |
The effects of allopurinol on serum and urinary uric acid.
Topics: Adult; Aged; Blood; Enzymes; Female; Gout; Humans; Male; Probenecid; Uric Acid; Urinary Calculi; Urine; Xanthine Oxidase | 1966 |
Treatment of gout by reduction of uric acid production.
Topics: Catalase; Drug Synergism; Enzyme Therapy; Gout; Humans; Kidney Calculi; Sulfinpyrazone; Uracil; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1966 |
The chemistry of xanthine oxidase. Reaction with iodoacetamide.
Topics: Aldehydes; Amides; Animals; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; In Vitro Techniques; Iodides; Milk; Sulfites; Uric Acid; Xanthine Oxidase; Xanthines | 1966 |
Treatment of x-linked primary hyperuricemia with allopurinol.
Topics: Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Enzyme Therapy; Hematuria; Humans; Male; Metabolism, Inborn Errors; Self Mutilation; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1966 |
Allopurinol (xanthine oxidase inhibitor) in the treatment of resistant gout.
Topics: Adult; Aged; Colchicine; Enzyme Therapy; Enzymes; Female; Gout; Humans; Male; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Allopurinol in primary gout with and after the administration of uricosuric agents.
Topics: Allopurinol; Drug Synergism; Enzyme Therapy; Female; Gout; Humans; Male; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Allopurinol in the prevention of hyperuricaemia secondary to the treatment of neoplastic diseases with alkylating agents, adrenal steroids, and radiation therapy.
Topics: Adult; Allopurinol; Carbon Isotopes; Child; Cyclophosphamide; Enzyme Therapy; Female; Humans; Hydrocortisone; Leiomyosarcoma; Leukemia; Male; Middle Aged; Myeloproliferative Disorders; Prednisone; Purines; Radiotherapy; Uric Acid; Uricosuric Agents; Xanthine Oxidase; Xanthines | 1966 |
Allopurinol in thiazide-induced hyperuricaemia.
Topics: Allopurinol; Clopamide; Enzyme Therapy; Gout; Hematologic Diseases; Humans; Hypertension; Kidney Failure, Chronic; Polythiazide; Uric Acid; Xanthine Oxidase | 1966 |
Effects of allopurinol on gouty and non-gouty uric acid nephropathy.
Topics: Allopurinol; Blood Urea Nitrogen; Enzyme Therapy; Female; Gout; Humans; Kidney Calculi; Kidney Diseases; Male; Salicylates; Sulfinpyrazone; Uric Acid; Xanthine Oxidase | 1966 |
Allopurinol in patients with impaired renal function.
Topics: Adolescent; Adult; Aged; Allopurinol; Child; Creatine; Enzyme Therapy; Female; Gout; Humans; Hydrogen-Ion Concentration; Hypoxanthines; Kidney Calculi; Kidney Failure, Chronic; Male; Middle Aged; Uric Acid; Xanthine Oxidase; Xanthines | 1966 |
Allopurinol therapy of gout with renal complications.
Topics: Adult; Allopurinol; Calcium; Creatine; Enzyme Therapy; Gout; Humans; Kidney Failure, Chronic; Male; Middle Aged; Probenecid; Uric Acid; Xanthine Oxidase | 1966 |
Allopurinol in the prophylaxis of uric acid stones.
Topics: Allopurinol; Enzyme Therapy; Female; Gout; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Male; Uric Acid; Xanthine Oxidase | 1966 |
Metabolic studies of allopurinol, an inhibitor of xanthine oxidase.
Topics: Allopurinol; Animals; Brain Chemistry; Carbon Dioxide; Carbon Isotopes; Chromatography, Paper; Dogs; Enzymes; Heart; Humans; Hypoxanthines; Intestines; Liver; Lung; Mice; Pyrimidines; Spleen; Uric Acid; Xanthine Oxidase; Xanthines | 1966 |
[Clinical aspects of chronic gout].
Topics: Adult; Aged; Allopurinol; Anemia; Arthritis; Bicarbonates; Blood Sedimentation; Chronic Disease; Female; Gout; Humans; Joint Diseases; Male; Middle Aged; Phenylbutazone; Physical Exertion; Probenecid; Uric Acid | 1966 |
[Influence of some therapeutic agents on the biosynthesis of uric acid].
Topics: Animals; Antipyrine; Benzoates; Chickens; Colchicine; Liver; Phenylbutazone; Rats; Salicylates; Swine; Uric Acid; Xanthine Oxidase | 1966 |
[Our experience in the treatment of hyperuricemia with a xanthine oxidase inhibitor (HPP), Allopurinol].
Topics: Allopurinol; Gout; Humans; Uric Acid; Xanthine Oxidase | 1966 |
[Prevention of hyperuricemia and its complications with allopurinol, in the treatment of several hematologic diseases].
Topics: Adult; Allopurinol; Hematologic Diseases; Humans; Male; Middle Aged; Uric Acid | 1966 |
[Etiologic and therapeutic studies of lithiasis caused by uric acid].
Topics: Allopurinol; Calculi; Humans; Uric Acid | 1966 |
Use of allopurinol in gout, hyperuricemia and uric acid lithiasis.
Topics: Adult; Aged; Allopurinol; Blood Urea Nitrogen; Colchicine; Enzyme Therapy; Female; Gout; Humans; Indomethacin; Male; Middle Aged; Phenylbutazone; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1967 |
Treatment of uric acid urolithiasis with allopurinol: a xanthine oxidase inhibitor.
Topics: Adolescent; Allopurinol; Blood Urea Nitrogen; Enzyme Therapy; Humans; Male; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1967 |
Allopurinol control of hyperuricosuria: a new concept in the prevention of uric acid stones.
Topics: Adult; Aged; Allopurinol; Arthritis; Enzyme Therapy; Enzymes; Female; Humans; Male; Middle Aged; Uric Acid; Urinary Calculi | 1967 |
Hyperuricemia and mental retardation with athetosis and self-mutilation.
Topics: Allopurinol; Athetosis; Body Height; Body Weight; Child; Child, Preschool; Chorea; Humans; Infant; Intellectual Disability; Male; Probenecid; Self Mutilation; Uric Acid; Xanthine Oxidase | 1967 |
Allopurinol in the treatment of uraemic patients with gout.
Topics: Allopurinol; Blood Urea Nitrogen; Enzyme Therapy; Gout; Humans; Purines; Uremia; Uric Acid; Xanthine Oxidase | 1967 |
Urinary metabolites in congenital hyperuricosuria.
Topics: Allopurinol; Child; Child, Preschool; Humans; Hypoxanthines; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthines | 1967 |
Studies of uric acid metabolism in glycogen storage disease associated with gouty arthritis.
Topics: Adolescent; Allopurinol; Body Height; Body Weight; Carbon Isotopes; Enzyme Therapy; Glucosephosphate Dehydrogenase Deficiency; Glycine; Gout; Hepatomegaly; Humans; Male; Probenecid; Radiochemistry; Uric Acid; Xanthine Oxidase | 1967 |
Allopurinol in the treatment of neoplastic disease complicated by hyperuricemia.
Topics: Adult; Aged; Allopurinol; Enzyme Therapy; Enzymes; Female; Humans; Kidney; Male; Middle Aged; Neoplasms; Uric Acid; Xanthine Oxidase | 1967 |
Biochemical evidence for a distinct type of primary gout.
Topics: Adolescent; Allopurinol; Azathioprine; Carbon; Carbon Isotopes; Enzymes; Glycine; Gout; Humans; Hypoxanthines; Male; Purines; Uric Acid; Xanthine Oxidase; Xanthines | 1967 |
A method for the determination of xanthine and hypoxanthine in biological fluids.
Topics: Chromatography, Ion Exchange; Hydrogen-Ion Concentration; Hypoxanthines; Spectrophotometry; Ultraviolet Rays; Urate Oxidase; Uric Acid; Xanthine Oxidase; Xanthines | 1967 |
Treatment of gout.
Topics: Allopurinol; Enzyme Therapy; Gout; Humans; Uric Acid; Xanthine Oxidase | 1967 |
Effects of substrates on gene-controlled enzyme activities in cultured embryonic cells of Drosophila.
Topics: Alcohol Oxidoreductases; Alkaline Phosphatase; Cell Differentiation; Culture Techniques; DNA; Drosophila; Enzymes; Ethanol; Genes; Glycerophosphates; Hypoxanthines; Methanol; Phosphorus Isotopes; RNA; Uric Acid; Xanthine Oxidase; Xanthines | 1967 |
Use of allopurinol for control of hyperuricemia in leukemia and lymphoma.
Topics: Allopurinol; Antineoplastic Agents; Humans; Leukemia; Lymphoma; Uric Acid | 1967 |
Excretion of hypoxanthine and xanthine in a genetic disease of purine metabolism.
Topics: Allopurinol; Humans; Hypoxanthines; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthines | 1967 |
[Allopurinol treatment of hyperuricemia].
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Iron; Male; Middle Aged; Nitrogen; Purines; Uric Acid | 1967 |
The use of the xanthine oxidase inhibitor, allopurinol, in the control of hyperuricaemia, gout and uric acid calculi.
Topics: Adult; Aged; Allopurinol; Female; Gout; Humans; Hypoxanthines; Male; Metabolic Diseases; Middle Aged; Uric Acid; Uricosuric Agents; Urinary Calculi; Xanthine Oxidase; Xanthines | 1967 |
[Congenital hyperuricemia with neurologic, renal and blood disturbances].
Topics: Adolescent; Allopurinol; Anemia, Macrocytic; Athetosis; Chorea; Gout; Humans; Intellectual Disability; Male; Nephritis, Interstitial; Neurologic Manifestations; Uric Acid | 1967 |
The renal mechanism for urate homeostasis in normal man.
Topics: Adult; Allopurinol; Asian People; Biological Transport; Female; Glomerular Filtration Rate; Homeostasis; Humans; Kidney; Kidney Function Tests; Male; Pyrazinamide; Uric Acid; White People | 1967 |
An enzymatic spectrophotometric method for the determination of xanthine and hypoxanthine.
Topics: Hypoxanthines; Methods; Purines; Spectrophotometry; Uric Acid; Xanthine Oxidase; Xanthines | 1967 |
[Study of the effects of benziodarone in 100 gouty patients during a diuresis cure: effects on uric acid and oxalic acid].
Topics: Allopurinol; Benzofurans; Colchicine; Diuretics; Gout; Humans; Mineral Waters; Oxalates; Tromethamine; Uric Acid; Uricosuric Agents; Vasodilator Agents | 1967 |
Chemolysis of uric acid stones.
Topics: Adult; Aged; Allopurinol; Bicarbonates; Female; Humans; Kidney Calculi; Male; Middle Aged; Radiography; Sodium Bicarbonate; Uric Acid | 1984 |
[Drug induced lupus erythematodes (DILE). Minor tranquilizers and allopurinol as general inducers of the DILE syndrome?].
Topics: Adult; Allopurinol; Anti-Anxiety Agents; Antibodies, Antinuclear; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Uric Acid | 1980 |
Allupurinol and diuretic associated hyperuricaemia.
Topics: Allopurinol; Diuretics; Humans; Probenecid; Uric Acid; Uricosuric Agents | 1980 |
Hypouricaemic effect of polyethyleneglycol modified urate oxidase.
Topics: Aged; Allantoin; Allopurinol; Candida; Humans; Male; Middle Aged; Neoplasms; Polyethylene Glycols; Urate Oxidase; Uric Acid | 1981 |
Management of gout and hyperuricemia.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Gout; Humans; Indomethacin; Kidney; Patient Education as Topic; Phenylbutazone; Phosphoribosyl Pyrophosphate; Probenecid; Purines; Uric Acid; Uricosuric Agents | 1984 |
Hormonal aspects of human gout--excretion of adrenal hormone derivatives in gouty patients.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aging; Allopurinol; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Gout; Humans; Male; Middle Aged; Pregnanetriol; Triglycerides; Uric Acid | 1983 |
Metabolic basis for disorders of purine nucleotide degradation.
Topics: Adenosine Deaminase; Adenosine Monophosphate; Adenosine Triphosphate; AMP Deaminase; Anemia; Animals; Deoxyribonucleotides; Female; Gout; Humans; Hypoxia; Male; Nucleotidases; Phosphorylation; Purine Nucleotides; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribonucleotides; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1981 |
An enzymatic spectrophotometric assay for inosinic acid.
Topics: Chemical Phenomena; Chemistry; Diphosphates; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Monophosphate; Inosine Nucleotides; Magnesium; Spectrum Analysis; Uric Acid; Xanthine Oxidase | 1981 |
Mechanism of allopurinol action in calcium oxalate stone formers.
Topics: Allopurinol; Calcium Oxalate; Citrates; Citric Acid; Creatinine; Diphosphates; Humans; Kidney Calculi; Lactates; Lactic Acid; Oxalates; Uric Acid | 1981 |
Oxygen free-radicals mediate an inhibition of proteoglycan synthesis in cultured articular cartilage.
Topics: Animals; Cartilage, Articular; Cattle; Culture Techniques; Free Radicals; Glycosaminoglycans; Glycosides; Hypoxanthine; Hypoxanthines; Protein Biosynthesis; Proteoglycans; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine Oxidase | 1984 |
Xanthine oxidase deficiency and 'Dalmatian' hypouricaemia: incidence and effect of exercise.
Topics: Erythrocytes; Exercise Test; Humans; Hypoxanthines; Kidney Tubules; Male; Retrospective Studies; Time Factors; Uric Acid; Xanthine Oxidase; Xanthines | 1983 |
[Skin eruption during combined treatment with ampicilin, amoxicilin and allopurinol].
Topics: Allopurinol; Amoxicillin; Ampicillin; Drug Eruptions; Drug Interactions; Drug Therapy, Combination; Humans; Male; Middle Aged; Uric Acid | 1980 |
Potentiation of ampicillin skin reactions by allopurinol or hyperuricemia.
Topics: Allopurinol; Ampicillin; Drug Eruptions; Drug Synergism; Female; Humans; Male; Uric Acid | 1981 |
Management of the stone former.
Topics: Allopurinol; Calcium; Cellulose; Cystinuria; Diet; Drug-Related Side Effects and Adverse Reactions; Humans; Hydrochlorothiazide; Kidney Calculi; Magnesium; Phosphates; Uric Acid; Urinary Calculi | 1984 |
An approach to hyperuricemia and gout.
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Female; Gout; Humans; Male; Naproxen; Phenylbutazone; Prognosis; Sulfinpyrazone; Uric Acid | 1984 |
Change in inhibitory potential in urine of hyperuricosuric calcium oxalate stone formers effected by allopurinol and orthophosphates.
Topics: Allopurinol; Calcium Oxalate; Female; Humans; Kidney Calculi; Male; Uric Acid | 1984 |
Does benzbromarone in therapeutic doses raise renal excretion of oxipurinol?
Topics: Adult; Aged; Allopurinol; Benzbromarone; Benzofurans; Creatinine; Drug Therapy, Combination; Glomerular Filtration Rate; Gout; Humans; Male; Middle Aged; Oxypurinol; Pyrimidines; Uric Acid | 1984 |
[Calcium lithiasis: uric acid under question].
Topics: Allopurinol; Calcium; Humans; Kidney Calculi; Oxalates; Uric Acid; Uricosuric Agents | 1984 |
[Crystalluria during prophylactic treatment of urinary lithiasis with allopurinol, hydrochlorothiazide, manganese oxide, diphosphonates and propionohydroxamic acid].
Topics: Allopurinol; Anti-Bacterial Agents; Calcium; Crystallization; Diphosphonates; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hydroxamic Acids; Kidney Calculi; Manganese; Manganese Compounds; Oxides; Uric Acid | 1984 |
Hypoxanthine concentrations in normal subjects and patients with solid tumors and leukemia.
Topics: Acute Disease; Allopurinol; Bone Marrow; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Circadian Rhythm; Half-Life; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Neoplasms; Reference Values; Uric Acid | 1984 |
[Familial xanthinuria, 2 new cases].
Topics: Adult; Female; Humans; Middle Aged; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Oxidase; Xanthines | 1984 |
Clinicobiochemical analysis of four cases of xanthine oxidase deficiency.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1984 |
Uric acid: functions and determination.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Female; Humans; Male; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1984 |
Hypouricemic action of diflunisal in gouty patients: in vitro and in vivo studies.
Topics: Adult; Aged; Creatinine; Diflunisal; Enzyme Inhibitors; Gout; Humans; In Vitro Techniques; Middle Aged; Salicylates; Uric Acid; Xanthine Oxidase; Xanthines | 1984 |
Xanthine:NAD+ oxidoreductase in the liver of grass snake Natrix natrix.
Topics: Animals; Hypoxanthines; Liver; NAD; Snakes; Substrate Specificity; Uric Acid; Xanthine Oxidase | 1984 |
Inhibition of free radical-induced DNA damage by uric acid.
Topics: Acetaldehyde; Animals; Cell Nucleus; DNA; DNA, Single-Stranded; Free Radicals; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Uric Acid; Xanthine Oxidase | 1984 |
The use of xanthine oxidase for a specific and sensitive fluorimetric determination of 6-mercaptopurine in serum.
Topics: Chromatography, High Pressure Liquid; Humans; Kinetics; Mercaptopurine; Oxidation-Reduction; Spectrometry, Fluorescence; Uric Acid; Xanthine Oxidase | 1984 |
Effect of allopurinol treatment in premature infants with idiopathic respiratory distress syndrome.
Topics: Allopurinol; Creatinine; Female; Humans; Infant, Newborn; Male; Prospective Studies; Random Allocation; Respiratory Distress Syndrome, Newborn; Uric Acid; Xanthine Oxidase | 1984 |
Renal failure in infancy due to over-production of urate.
Topics: Allopurinol; Aortic Coarctation; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Kidney Failure, Chronic; Male; Uric Acid | 1984 |
Oxipurinol therapy in allopurinol-allergic patients.
Topics: Aged; Allopurinol; Arthritis; Drug Hypersensitivity; Female; Gout; Humans; Oxypurinol; Pyrimidines; Uric Acid | 1983 |
Cutaneous gout in an Amazon dolphin.
Topics: Allopurinol; Animals; Animals, Zoo; Dolphins; Gout; Male; Skin; Skin Diseases; Uric Acid | 1983 |
A prospective study of the development of hypertension and renal stone disease in subjects with increased blood urate.
Topics: Allopurinol; Blood Pressure; Female; Humans; Hypertension; Kidney Calculi; Male; Middle Aged; Prospective Studies; Uric Acid | 1983 |
[Uric acid-lowering effect of a combination of benzbromarone and allopurinol--studies under standardized dietary conditions].
Topics: Adult; Allopurinol; Benzbromarone; Benzofurans; Depression, Chemical; Diet; Erythrocytes; Female; Humans; Kidney; Male; Orotic Acid; Time Factors; Uric Acid | 1983 |
Prevention of recurrent uric acid and calcium oxalate stones by administration of the xanthine oxidase inhibitors Milurit 100 and Milurit 300.
Topics: Adolescent; Adult; Aged; Allopurinol; Calcium Oxalate; Female; Humans; Male; Middle Aged; Oxypurinol; Recurrence; Uric Acid; Urinary Calculi; Xanthine Oxidase | 1983 |
Allopurinol metabolism in a patient with xanthine oxidase deficiency.
Topics: Allopurinol; Female; Graves Disease; Humans; Hypoxanthines; Male; Middle Aged; Oxypurinol; Time Factors; Uric Acid; Xanthine Oxidase; Xanthines | 1983 |
Free nucleosides and bases in the hyperkeratotic epidermis.
Topics: Animals; Chromatography, High Pressure Liquid; Epidermis; Guinea Pigs; Keratosis; Nucleosides; Proteins; Purines; Pyrimidines; Uric Acid; Xanthine Oxidase | 1983 |
[Effects of nitroimidazole and nitrofuran derivatives on uric acid formation in an anaerobic environment by xanthine oxidase and microsomal nitroreductase].
Topics: Animals; In Vitro Techniques; Microsomes; Nitrofurans; Nitroimidazoles; Nitroreductases; Oxidoreductases; Rats; Rats, Inbred Strains; Uric Acid; Xanthine Oxidase | 1983 |
Gout and uric acid nephropathy: some new aspects in diagnosis and treatment.
Topics: Adult; Diet; Female; Gout; Humans; Hypolipidemic Agents; Kidney Diseases; Male; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1983 |
Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency.
Topics: Adult; Aged; Allopurinol; Creatinine; Female; Humans; Kidney Diseases; Male; Middle Aged; Syndrome; Uric Acid | 1984 |
Absorption and metabolism of allopurinol and oxypurinol by rat jejunum in vitro: effects on uric acid transport.
Topics: Allopurinol; Animals; Biological Transport; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Oxypurinol; Pyrimidines; Rats; Rats, Inbred Strains; Uric Acid; Xanthines | 1984 |
Azapropazone--a treatment for hyperuricaemia and gout?
Topics: Adult; Aged; Allopurinol; Apazone; Creatinine; Gout; Humans; Middle Aged; Osmolar Concentration; Triazines; Uric Acid; Urination | 1984 |
[Treatment of atherosclerosis with hypolipidemic and antiuricemic agents].
Topics: Adult; Aged; Allopurinol; Arteriosclerosis; Coronary Disease; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypolipidemic Agents; Lipids; Male; Middle Aged; Uric Acid | 1984 |
High-performance liquid chromatography with polarographic and voltammetric anodic detection: simultaneous determination of allopurinol, oxipurinol and uric acid in body fluids.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Oxypurinol; Polarography; Pyrimidines; Uric Acid | 1984 |
Gout resistant to allopurinol: poor compliance or non-response.
Topics: Allopurinol; Arthritis; Gout; Humans; Male; Middle Aged; Patient Compliance; Uric Acid | 1984 |
Uricostatic effect of allopurinol in the allantoxanamide-treated rat: a new method for evaluating antiuricopathic drugs.
Topics: Allopurinol; Animals; Kinetics; Male; Oxonic Acid; Rats; Rats, Inbred Strains; Triazines; Urate Oxidase; Uric Acid | 1984 |
The excretion of 14C-hypoxanthine and its metabolites in rats following administration of uricostatic drugs.
Topics: Allantoin; Allopurinol; Animals; Carbon Radioisotopes; Dose-Response Relationship, Drug; Hypoxanthine; Hypoxanthines; Male; Rats; Rats, Inbred Strains; Uric Acid; Xanthine; Xanthines | 1984 |
Therapeutics of hyperuricaemia and gout.
Topics: Acute Disease; Allopurinol; Colchicine; Gout; Humans; Indomethacin; Uric Acid; Uricosuric Agents | 1984 |
In vitro and in vivo arachidonic acid conversions into biologically active derivatives are enhanced by uric acid.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biotransformation; Male; Microsomes, Liver; Oxygen Consumption; Prostaglandins; Purines; Rabbits; Stimulation, Chemical; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1981 |
[Long-term treatment and prevention of uric acid urolithiasis with allopurinol].
Topics: Aged; Allopurinol; Female; Humans; Long-Term Care; Male; Middle Aged; Uric Acid; Urinary Calculi | 1982 |
Successful medical management of bilateral ureteral obstruction due to acute uric acid nephropathy.
Topics: Allopurinol; Humans; Kidney Diseases; Male; Middle Aged; Renal Dialysis; Ureteral Obstruction; Uric Acid | 1983 |
[Current therapy: combined drug therapy of hyperuricemia, gout and alcohol induced fatty liver].
Topics: Allopurinol; Benzbromarone; Benzofurans; Drug Therapy, Combination; Fatty Liver, Alcoholic; Gout; Humans; Hypoxanthine; Hypoxanthines; Uric Acid; Xanthine; Xanthines | 1983 |
[Therapy of hyperuricemia and gout. Effect of a combination therapy of allopurinol with benzbromarone].
Topics: Allopurinol; Benzbromarone; Benzofurans; Chemical Phenomena; Chemistry; Drug Therapy, Combination; Gout; Humans; Uric Acid | 1983 |
Serum xanthine oxidase in breast carcinoma.
Topics: Adult; Aged; Breast Neoplasms; Female; Humans; Middle Aged; NAD; Neoplasm Staging; Time Factors; Uric Acid; Xanthine Oxidase; Xanthines | 1980 |
The effect of oxidant stress on human lymphocyte cytotoxicity.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Cell Survival; Humans; Hydrogen Peroxide; Lymphocytes; Oxygen; Rabbits; Superoxide Dismutase; Uric Acid; Xanthine Oxidase; Xanthines | 1980 |
Failure of folic acid (pteroylglutamic acid) to affect hyperuricemia.
Topics: Adult; Dose-Response Relationship, Drug; Female; Folic Acid; Gout; Humans; Hypoxanthines; Liver; Male; Uric Acid; Xanthine Oxidase | 1980 |
Inhibitory effects of methylxanthines on the activity of xanthine oxidase.
Topics: Animals; Brain; Buffaloes; Caffeine; Female; In Vitro Techniques; Kidney; Kinetics; Lung; Milk; Myocardium; Rats; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase; Xanthines | 1980 |
Clinical disorders of uric acid metabolism.
Topics: Amidophosphoribosyltransferase; Diet; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Kidney; Kidney Failure, Chronic; Metabolic Diseases; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1981 |
Xanthine oxidase in serum of viral hepatitis patients may interfere in urate determination by endpoint measurement with xanthine in the reagent mixture.
Topics: Hepatitis, Viral, Human; Humans; Methods; Uric Acid; Xanthine Oxidase | 1981 |
Hyperuricemia and gout: an update.
Topics: Allopurinol; Female; Gout; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1981 |
Catecholamine-induced hyperuricemia in eviscerated rats with functional hepatectomy.
Topics: Animals; Catecholamines; Hepatectomy; Isoproterenol; Liver; Male; Propranolol; Rats; Rats, Inbred Strains; Uric Acid; Xanthine Oxidase | 1981 |
Increase in microvascular permeability induced by enzymatically generated free radicals. I. In vivo study.
Topics: Animals; Capillary Permeability; Cheek; Cricetinae; Inflammation; Male; Mesocricetus; Oxygen; Uric Acid; Xanthine Oxidase | 1981 |
Oxidation-reduction potentials of molybdenum, flavin, and iron-sulfur centers in milk xanthine oxidase: variation with pH.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Iron; Milk; Molybdenum; Oxidation-Reduction; Sulfur; Uric Acid; Xanthine Oxidase | 1982 |
Urinary excretion of uric acid in iron deficient rats.
Topics: Anemia, Hypochromic; Animals; Liver; Male; Rats; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1982 |
The effects of allopurinol treatment on stone formation on hyperuricosuric calcium oxalate stone-formers.
Topics: Allopurinol; Calcium Oxalate; Humans; Kidney Calculi; Uric Acid | 1980 |
Urate-oxidase prophylaxis of uric acid-induced renal damage in childhood leukemia.
Topics: Allopurinol; Antineoplastic Agents; Child; Child, Preschool; Diuresis; Female; Humans; Infant; Kidney Diseases; Leukemia, Lymphoid; Male; Urate Oxidase; Uric Acid | 1982 |
Acute lymphocytic leukemia in a child with congenital xanthine oxidase deficiency: implications for therapy.
Topics: Adolescent; Allopurinol; Asparaginase; Female; Humans; Leukemia, Lymphoid; Methotrexate; Prednisone; Thioinosine; Uric Acid; Vincristine; Xanthine Oxidase | 1981 |
[Life-threatening hyperuricemia during cytostatic leukemia therapy].
Topics: Adolescent; Allopurinol; Asparaginase; Child; Humans; Leukemia, Lymphoid; Male; Methylprednisolone; Pentamidine; Pulmonary Fibrosis; Uric Acid; Vincristine | 1982 |
[Therapeutic effectiveness of the combination allopurinol-benziodarone in the treatment of hyperuricemia].
Topics: Administration, Oral; Adult; Aged; Allopurinol; Benzofurans; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Uric Acid | 1982 |
Quantification of renal uric acid synthesis in the rat.
Topics: Allopurinol; Animals; Carbon Radioisotopes; Hypoxanthines; Kidney; Male; Radioisotope Dilution Technique; Rats; Uric Acid | 1980 |
Factors that predict relapse of calcium nephrolithiasis during treatment: a prospective study.
Topics: Allopurinol; Benzothiadiazines; Calcium; Diuretics; Female; Humans; Kidney Calculi; Male; Prospective Studies; Recurrence; Risk; Sodium Chloride Symporter Inhibitors; Uric Acid | 1982 |
Formation of a single calcium stone of renal origin. Clinical and laboratory characteristics of patients.
Topics: Adult; Allopurinol; Calcium; Female; Humans; Kidney Calculi; Male; Middle Aged; Recurrence; Trichlormethiazide; Uric Acid | 1982 |
Simultaneous determination of allopurinol, oxipurinol and uric acid in human plasma by high-performance liquid chromatography.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Humans; Microchemistry; Oxypurinol; Pyrimidines; Uric Acid | 1982 |
[Treatment of cytostatic-induced hyperuricaemia with allopurinol (author's transl)].
Topics: Adenocarcinoma; Allopurinol; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Female; Gout; Humans; Kidney Neoplasms; Lymphoma; Plasmacytoma; Sarcoma; Uric Acid | 1982 |
Gout and its manifestations in the head and neck.
Topics: Allopurinol; Arthritis; Colchicine; Ear, External; Gout; Head; Humans; Indomethacin; Laryngeal Cartilages; Male; Neck; Skin Manifestations; Uric Acid | 1982 |
[Recurrent urolithiasis--analysis of its etiology and treatment].
Topics: Adult; Allopurinol; Calcium; Female; Humans; Magnesium; Male; Middle Aged; Oxalates; Phosphates; Recurrence; Uric Acid; Urinary Calculi; Urinary Tract Infections | 1982 |
[Treatment of hyperuricemia].
Topics: Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Uric Acid | 1981 |
[Effect of long-term base therapy on the clinical picture of gout].
Topics: Adult; Allopurinol; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Female; Gout; Humans; Male; Middle Aged; Probenecid; Sulfinpyrazone; Time Factors; Uric Acid | 1981 |
Postchemotherapy purine excretion in lymphoma patients receiving allopurinol.
Topics: Acute Kidney Injury; Allopurinol; Antineoplastic Agents; Humans; Hypoxanthines; Lymphoma; Purines; Time Factors; Uric Acid; Xanthines | 1981 |
Selected physiologic and drug effects on serum uric acid levels in an elderly population.
Topics: Aged; Allopurinol; Diuretics; Female; Humans; Hypertension; Male; Obesity; Probenecid; Thyroid Diseases; Uric Acid | 1981 |
Dynamometric and biochemical observations in Duchenne patients receiving allopurinol.
Topics: Adenine; Allopurinol; Child; Creatine Kinase; Erythrocytes; Humans; Muscle Contraction; Muscular Dystrophies; Uric Acid | 1981 |
Hyperuricosuria and calcium nephrolithiasis.
Topics: Allopurinol; Calcium; Calcium Oxalate; Crystallization; Female; Humans; Kidney Calculi; Male; Meat; Models, Molecular; Uric Acid | 1981 |
Diagnostic and therapeutic aids in gout and hyperuricemia.
Topics: Acute Disease; Allopurinol; Arthritis, Rheumatoid; Colchicine; Diagnosis, Differential; Gout; Humans; Probenecid; Uremia; Uric Acid; Uricosuric Agents | 1981 |
Effects of exercise performance on drugs used in musculoskeletal disorders.
Topics: Allopurinol; Analgesics; Anti-Inflammatory Agents; Bone Diseases; Colchicine; Gout; Humans; Muscle Relaxants, Central; Muscular Diseases; Physical Exertion; Probenecid; Prostaglandins; Uric Acid | 1981 |
Prevention of kidney stones.
Topics: Allopurinol; Benzothiadiazines; Calcium; Diuretics; Humans; Kidney Calculi; Sodium Chloride Symporter Inhibitors; Uric Acid | 1981 |
Prevention of calcium nephrolithiasis with low-dose thiazide, amiloride and allopurinol.
Topics: Adult; Allopurinol; Amiloride; Calcium; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Kidney Calculi; Male; Middle Aged; Pyrazines; Uric Acid | 1981 |
Urolithiasis in hyperuricemia and gout.
Topics: Adult; Allopurinol; Child; Female; Gout; Humans; Hypoxanthine Phosphoribosyltransferase; Male; Myeloproliferative Disorders; Neoplasms; Pedigree; Uric Acid; Urinary Calculi | 1981 |
[Erythrocyte purine phosphoribosyltransferase activity in girls with the Lesch-Nyhan syndrome].
Topics: Adenine Phosphoribosyltransferase; Allopurinol; Child; Child, Preschool; Erythrocytes; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Lesch-Nyhan Syndrome; Pentosyltransferases; Sodium Fluoride; Uric Acid | 1981 |
Nucleation kinetics in the calcium oxalate-sodium urate monohydrate system.
Topics: Allopurinol; Calcium Oxalate; Humans; Kinetics; Nephelometry and Turbidimetry; Uric Acid; Urinary Calculi | 1981 |
Enhanced purine salvage during allopurinol therapy: an important pharmacologic property in humans.
Topics: Adenine Nucleotides; Adult; Aged; Allopurinol; Child; Child, Preschool; Fibroblasts; Humans; Hypoxanthine; Hypoxanthines; Intestinal Mucosa; Middle Aged; Purines; Uric Acid | 1981 |
Methotrexate with thymidine, inosine, and allopurinol rescue: a phase I clinical study.
Topics: Adult; Aged; Allopurinol; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypoxanthines; Infusions, Parenteral; Inosine; Male; Methotrexate; Middle Aged; Thymidine; Uric Acid | 1981 |
A case of chronic veno-occlusive disease of the liver.
Topics: Allopurinol; Budd-Chiari Syndrome; Chronic Disease; Humans; Liver; Male; Middle Aged; Uric Acid | 1981 |
Uric acid in the etiology of psoriasis.
Topics: Allopurinol; Animals; Crystallization; Humans; Psoriasis; Purines; Skin; Snakes; Uric Acid | 1981 |
[Acute attack of gout].
Topics: Acute Disease; Allopurinol; Bed Rest; Breathing Exercises; Colchicine; Female; Gout; Humans; Indomethacin; Male; Prednisolone; Uric Acid | 1981 |
Rat hepatic xanthine oxidase activity: age and sex specific differences.
Topics: Age Factors; Animals; Castration; Creatinine; Estradiol; Female; Gonads; Hypoxanthine Phosphoribosyltransferase; Liver; Male; Rats; Sex Factors; Sexual Maturation; Testosterone; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1980 |
Oxypurinol nephrolithiasis in regional enteritis secondary to allopurinol therapy.
Topics: Adult; Allopurinol; Crohn Disease; Female; Humans; Kidney Calculi; Oxypurinol; Pyrimidines; Uric Acid; Xanthines | 1980 |
[The use of allopurinol in long-term treatments for optimal effect].
Topics: Allopurinol; Biological Availability; Dose-Response Relationship, Drug; Gout; Half-Life; Humans; Kinetics; Oxypurinol; Uric Acid | 1980 |
[Uric acid-induced diseases. 2. Therapy].
Topics: Allopurinol; Benzbromarone; Benzothiadiazines; Diuretics; Gout; Humans; Purines; Sodium Chloride Symporter Inhibitors; Uric Acid; Urinary Calculi | 1980 |
Purine metabolism during strenuous muscular exercise in man.
Topics: Adenine Nucleotides; Adult; Aged; Allopurinol; Blood Chemical Analysis; Humans; Inosine; Male; Middle Aged; Muscles; Physical Exertion; Purinones; Uric Acid | 1980 |
Urine composition in patients with renal stone disease during treatment with allopurinol.
Topics: Allopurinol; Calcium; Creatinine; Female; Humans; Kidney Calculi; Magnesium; Male; Oxalates; Recurrence; Uric Acid; Urine | 1980 |
Neutropenia during allopurinol treatment in total therapeutic starvation.
Topics: Adult; Agranulocytosis; Allopurinol; Female; Humans; Male; Neutropenia; Obesity; Starvation; Uric Acid | 1980 |
Uric acid saturation in calcium nephrolithiasis.
Topics: Adolescent; Adult; Aged; Allopurinol; Calcium Oxalate; Female; Humans; Hydrogen-Ion Concentration; Kidney Calculi; Male; Middle Aged; Sodium; Uric Acid | 1980 |
Hyperuricemia in cyanotic congenital heart disease.
Topics: Adolescent; Adult; Allopurinol; Arthritis; Child; Child, Preschool; Gout; Heart Defects, Congenital; Humans; Kidney Diseases; Middle Aged; Uric Acid | 1980 |
Purine metabolism in Duchenne muscular dystrophy.
Topics: Adenine; Allopurinol; Biological Transport; Creatine Kinase; Erythrocyte Membrane; Female; Humans; Male; Muscles; Muscular Dystrophies; Purine Nucleotides; Uric Acid | 1980 |
Studies with allopurinol in patients with impaired renal function.
Topics: Allopurinol; Humans; Kidney; Kidney Failure, Chronic; Oxypurinol; Renal Dialysis; Uric Acid | 1980 |
Hyperuricosuric calcium oxalate nephrolithiasis.
Topics: Allopurinol; Calcium Oxalate; Diet; Female; Humans; Kidney Calculi; Male; Purines; Uric Acid | 1980 |
Inhibition of calcium oxalate crystal growth in urine during treatment with allopurinol.
Topics: Allopurinol; Calcium Oxalate; Crystallization; Humans; Male; Uric Acid; Urinary Calculi | 1980 |
Simultaneous liquid chromatography of 5-fluorouracil, uridine, hypoxanthine, xanthine, uric acid, allopurinol, and oxipurinol in plasma.
Topics: Allopurinol; Blood Platelets; Chromatography, High Pressure Liquid; Erythrocytes; Fluorouracil; Humans; Hypoxanthines; Oxypurinol; Purinones; Pyrimidines; Uric Acid; Uridine; Xanthines | 1980 |
Familial gout and renal failure in young women.
Topics: Acute Kidney Injury; Adolescent; Adult; Allopurinol; Child; Female; Gout; Humans; Middle Aged; Uric Acid | 1980 |
[Use of milurite in ischemic heart disease].
Topics: Adult; Aged; Allopurinol; Anabolic Agents; Coronary Disease; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Purines; Uric Acid | 1980 |
[Our experience with medical treatment of uric lithiasis].
Topics: Acetazolamide; Adult; Aged; Allopurinol; Antacids; Calcium; Diuretics; Female; Humans; Male; Middle Aged; Piperazines; Tromethamine; Uric Acid; Uricosuric Agents; Urinary Calculi; Urography | 1980 |
[Gout as a joint disease and as a generalized disease. Incidence, diagnosis and therapy].
Topics: Allopurinol; Colchicine; Diabetes Complications; Gout; Humans; Hypertension; Indomethacin; Kidney Diseases; Obesity; Proteinuria; Socioeconomic Factors; Synovial Fluid; Uric Acid; Urinary Calculi | 1980 |
Determination of selected pyrimidines, purines and their metabolites in serum and urine by reversed-phase ion-pair chromatography.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Humans; Purines; Pyrimidines; Uric Acid | 1980 |
[Inhibitors and stimulators of formation of urinary calculi and their role in the etiology of calcium urolithiasis].
Topics: Allopurinol; Calcium Phosphates; Humans; Magnesium; Uric Acid; Urinary Calculi | 1980 |
[Prevention of acute urate nephropathy].
Topics: Acute Disease; Adolescent; Adult; Aged; Allopurinol; Antineoplastic Agents; Bicarbonates; Drug Therapy, Combination; Female; Fluid Therapy; Humans; Kidney Diseases; Leukemia; Male; Middle Aged; Uremia; Uric Acid | 1980 |
Xanthine oxidase inhibitory activity of some Panamanian plants from Celastraceae and Lamiaceae.
Topics: Ethanol; Panama; Plant Extracts; Plants, Medicinal; Reference Standards; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 1995 |
Cyclosporine-induced hyperuricemia and gout in renal transplants.
Topics: Adult; Allopurinol; Azathioprine; Cyclosporine; Drug Interactions; Gout; Gout Suppressants; Humans; Immunosuppressive Agents; Kidney Transplantation; Uric Acid | 1995 |
Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon.
Topics: Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Molecular Structure; Plant Extracts; Plants, Medicinal; Quercetin; Uric Acid; Xanthine Oxidase | 1994 |
In vivo electrochemical monitoring of serotonin in spinal dorsal horn with Nafion-coated multi-carbon fiber electrodes.
Topics: Allopurinol; Animals; Biosensing Techniques; Clorgyline; Electrochemistry; Electrodes; Fluorocarbon Polymers; Hydroxyindoleacetic Acid; Male; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Serotonin; Spinal Cord; Uric Acid; Xanthine Oxidase | 1995 |
[Electrolytic changes in children with acute lymphoblastic leukemia during remission induction].
Topics: Adolescent; Allopurinol; Anions; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Blood Urea Nitrogen; Cations; Child; Child, Preschool; Cohort Studies; Creatinine; Epirubicin; Female; Humans; Hydrocortisone; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Remission Induction; Risk Factors; Serum Albumin; Uric Acid; Vincristine; Water-Electrolyte Imbalance | 1995 |
Granulomatous interstitial nephritis secondary to allopurinol treatment.
Topics: Allopurinol; Female; Granuloma; Humans; Kidney; Middle Aged; Nephritis, Interstitial; Uric Acid | 1995 |
[Allopurinol hypersensitivity. A possible cause of hepatitis and mucocutaneous eruptions in a patient undergoing antitubercular treatment].
Topics: Adult; Allopurinol; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; Drug Interactions; Humans; Male; Pyrazinamide; Tuberculosis, Pulmonary; Uric Acid | 1995 |
Abnormal purine and pyrimidine metabolism in inherited superactivity of PRPP synthetase.
Topics: Adenine Nucleotides; Allopurinol; Child; Erythrocytes; Female; Guanine Nucleotides; Humans; Hypoxanthine; Hypoxanthines; Inosine; Male; NAD; Nuclear Family; Purine-Pyrimidine Metabolism, Inborn Errors; Reference Values; Ribonucleotides; Ribose-Phosphate Pyrophosphokinase; Uric Acid; Uridine; Uridine Diphosphate Glucose; Xanthine; Xanthines | 1994 |
Renal clearances of purine bases and oxypurinol during glucose infusion.
Topics: Adult; Allopurinol; Glucose; Humans; Infusions, Intravenous; Kidney; Male; Mannitol; Oxypurinol; Reference Values; Serum Albumin; Uric Acid; Xanthine; Xanthines | 1994 |
Influence of allopurinol and two diets on 24-hour urinary excretions of uric acid, xanthine, and ammonia by healthy dogs.
Topics: Allopurinol; Ammonia; Animals; Diet, Protein-Restricted; Dietary Proteins; Dogs; Female; Food-Drug Interactions; Uric Acid; Urinary Calculi; Xanthines | 1995 |
Determination of plasma purine nucleoside phosphorylase activity by high-performance liquid chromatography.
Topics: Adult; Aged; Asthma; Calibration; Chromatography, High Pressure Liquid; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hypoxanthine; Hypoxanthines; Inosine; Male; Middle Aged; Purine-Nucleoside Phosphorylase; Thiazoles; Uric Acid; Xanthine Oxidase | 1995 |
Inactivation of protease nexin-1 by xanthine oxidase-derived free radicals.
Topics: Amyloid beta-Protein Precursor; Animals; Antioxidants; Brain; Carrier Proteins; Catalase; Free Radical Scavengers; Nitroblue Tetrazolium; Oxidation-Reduction; Protease Nexins; Rats; Reactive Oxygen Species; Receptors, Cell Surface; Recombinant Proteins; Superoxide Dismutase; Thrombin; Uric Acid; Vitamin E; Xanthine Oxidase | 1995 |
Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat.
Topics: Allopurinol; Animals; Brain Stem; Corpus Striatum; Dopamine; Male; Manganese; Norepinephrine; Oxidative Stress; Rats; Rats, Wistar; Uric Acid; Xanthine; Xanthines | 1995 |
Missed opportunity following diagnosis of gout.
Topics: Adult; Allopurinol; Beer; Cardiovascular Diseases; Gout; Humans; Lipoproteins; Male; Risk Factors; Uric Acid | 1995 |
Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects. I. Uric acid kinetics.
Topics: Administration, Oral; Adult; Allopurinol; Drug Interactions; Humans; Hydrochlorothiazide; Male; Oxypurinol; Reference Values; Time Factors; Uric Acid | 1994 |
Specificity in the recognition of crystals by antibodies.
Topics: Allopurinol; Animals; Antibody Specificity; Antigen-Antibody Reactions; Binding Sites, Antibody; Cross Reactions; Crystallization; Immunization; Immunoglobulin G; Molecular Structure; Rabbits; Uric Acid | 1994 |
Effects of allopurinol on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurochemical changes in the striatum and in the brainstem of the rat.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Allopurinol; Animals; Ascorbic Acid; Brain Stem; Dopamine; Glutathione; Hypoxanthine; Hypoxanthines; Male; Neostriatum; Norepinephrine; Rats; Rats, Wistar; Uric Acid; Xanthines | 1995 |
Enhancement by zinc acetate of 1-nitropyrene binding to DNA in the hypoxanthine-xanthine oxidase system.
Topics: Acetates; Acetic Acid; Animals; Binding, Competitive; Cattle; Chromatography, High Pressure Liquid; DNA; DNA, Bacterial; Drug Synergism; Hypoxanthine; Hypoxanthines; Mutagens; Nucleic Acid Conformation; Polydeoxyribonucleotides; Pyrenes; Salmonella typhimurium; Uric Acid; Xanthine Oxidase | 1995 |
Effect of glucose infusion on the renal transport of purine bases and oxypurinol.
Topics: Adult; Allopurinol; Biological Transport, Active; Diabetes Complications; Diabetes Mellitus; Glucose; Gout; Half-Life; Humans; Hypoxanthine; Hypoxanthines; Infusions, Intravenous; Kidney; Male; Mannitol; Oxypurinol; Purines; Uric Acid; Xanthine; Xanthines | 1995 |
[Allopurinol].
Topics: Allopurinol; Arthritis, Gouty; Humans; Uric Acid; Urinary Calculi | 1994 |
Molecular recognition. Crystallographic antibodies.
Topics: Allopurinol; Animals; Antibodies; Catalysis; Crystallization; Gout; Humans; Immunoglobulin G; Rabbits; Uric Acid | 1995 |
Electroconvulsive shock increases interstitial concentrations of uric acid in the rat brain.
Topics: Administration, Topical; Allopurinol; Animals; Brain; Corpus Striatum; Electroshock; Extracellular Space; Flurothyl; Injections, Intraperitoneal; Male; Microdialysis; Osmolar Concentration; Rats; Rats, Wistar; Tetrodotoxin; Uric Acid | 1994 |
Uric acid synthesis by rat liver supernatants from purine bases, nucleosides and nucleotides. Effect of allopurinol.
Topics: Allopurinol; Animals; Carbon-Nitrogen Ligases; Female; Ligases; Liver Extracts; Purine Nucleotides; Pyrimidine Nucleotides; Rats; Uric Acid | 1994 |
Educational program to improve the dosage prescribing of allopurinol.
Topics: Allopurinol; Creatinine; Drug Prescriptions; Drug Utilization; Education, Medical, Continuing; Evaluation Studies as Topic; Family Practice; Humans; Information Systems; Interprofessional Relations; Kidney; Pharmacies; Pharmacists; Tasmania; Uric Acid | 1995 |
Comparison of energy metabolism in rat liver grafts during preservation in University of Wisconsin or Euro-Collins solutions.
Topics: Adenosine; Allopurinol; Animals; Energy Metabolism; Glutathione; Hypertonic Solutions; Hypoxanthine; Hypoxanthines; Inosine; Insulin; Lactates; Liver; Liver Transplantation; Male; Microdialysis; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Sprague-Dawley; Time Factors; Uric Acid; Xanthine; Xanthines | 1995 |
The effect of water loss upon the urate, urea and ammonia content of the egg of the Japanese quail Coturnix coturnix japonica.
Topics: Allopurinol; Ammonia; Animals; Coturnix; Ovum; Urea; Uric Acid; Water | 1993 |
Induction of the conversion of xanthine dehydrogenase to oxidase in rabbit liver by Cu2+,Zn2+ and selenium ions.
Topics: Allopurinol; Animals; Chromatography, High Pressure Liquid; Copper; In Vitro Techniques; Iron; Liver; Male; Rabbits; Selenium; Trypsin; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Zinc | 1994 |
Xanthine dehydrogenase and purine metabolism in man. With special reference to exercise.
Topics: Adolescent; Adult; Animals; Dogs; Exercise; Free Radicals; Humans; Hypoxanthine; Hypoxanthines; Inflammation; Liver; Male; Muscle, Skeletal; Myocardium; Purines; Rabbits; Rats; Reactive Oxygen Species; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1994 |
Effect of allopurinol on uric acid levels and brain cell membrane Na+,K(+)-ATPase activity during hypoxia in newborn piglets.
Topics: Allopurinol; Animals; Animals, Newborn; Brain; Cell Membrane; Free Radicals; Hypoxia, Brain; Lipid Peroxidation; Oxygen; Purines; Sodium-Potassium-Exchanging ATPase; Swine; Uric Acid | 1994 |
The pharmacokinetics of injectable allopurinol in newborns with the hypoplastic left heart syndrome.
Topics: Allopurinol; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Humans; Hypoplastic Left Heart Syndrome; Hypoxanthine; Hypoxanthines; Infant, Newborn; Infusions, Intravenous; Male; Oxypurinol; Time Factors; Uric Acid; Xanthine Oxidase | 1994 |
Calcium restriction, thiazide, citrate, and allopurinol in calcium oxalate nephrolithiasis.
Topics: Allopurinol; Benzothiadiazines; Calcium; Calcium Oxalate; Calcium, Dietary; Citrates; Diuretics; Humans; Kidney Calculi; Purines; Sodium Chloride Symporter Inhibitors; Uric Acid | 1994 |
Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Curcumin; Enzyme Induction; Mice; Tetradecanoylphorbol Acetate; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1994 |
High performance liquid chromatography analysis of hypoxanthine metabolism in mouse oocyte-cumulus cell complexes: effects of purine metabolic perturbants.
Topics: Adenylosuccinate Synthase; Alanine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Hypoxanthine; Hypoxanthines; Inosine; Inosine Monophosphate; Meiosis; Mercaptopurine; Mice; Mycophenolic Acid; Oocytes; Purine-Nucleoside Phosphorylase; Purines; Uric Acid; Xanthine Oxidase | 1994 |
Hypouricemic effect of allopurinol and the novel xanthine oxidase inhibitor TEI-6720 in chimpanzees.
Topics: Administration, Oral; Allopurinol; Animals; Dose-Response Relationship, Drug; Febuxostat; Female; Gout; Macaca mulatta; Male; Pan troglodytes; Thiazoles; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1993 |
Recurrence of acute renal failure and renal hypouricaemia.
Topics: Acute Kidney Injury; Adolescent; Humans; Male; Recurrence; Uric Acid; Xanthine Oxidase | 1993 |
Physiologic levels of uric acid inhibit xanthine oxidase in human plasma.
Topics: Adult; Age Factors; Free Radical Scavengers; Humans; Infant, Newborn; Oxidation-Reduction; Reactive Oxygen Species; Reperfusion Injury; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1993 |
[The use of Allomaron in treating hyperuricemia].
Topics: Adult; Allopurinol; Arthritis, Gouty; Benzbromarone; Creatinine; Drug Combinations; Drug Evaluation; Female; Gout; Humans; Male; Middle Aged; Time Factors; Uric Acid | 1994 |
Withdrawal of longterm antihyperuricemic therapy in tophaceous gout.
Topics: Adult; Allopurinol; Drug Administration Schedule; Gout; Humans; Middle Aged; Recurrence; Retrospective Studies; Time Factors; Uric Acid; Uricosuric Agents | 1993 |
[The postnatal development of porcine purine catabolism and the effect of the environmental temperature on turnover].
Topics: Animals; Animals, Suckling; Female; Liver; Male; Purines; Swine; Temperature; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1993 |
Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents.
Topics: Allantoin; Allopurinol; Animals; Cattle; Febuxostat; Gout Suppressants; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Thiazoles; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1993 |
Effect of uric acid on plasma levels of 1,25(OH)2D in renal failure.
Topics: Adult; Aged; Allopurinol; Animals; Calcitriol; Calcium; DNA; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Parathyroid Hormone; Phosphorus; Rats; Receptors, Calcitriol; Uric Acid | 1993 |
Hyperuricemia and urate nephropathy in urate oxidase-deficient mice.
Topics: Allopurinol; Animals; Arthritis, Gouty; Disease Models, Animal; Genes, Lethal; Humans; Kidney Calculi; Kidney Diseases; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Species Specificity; Urate Oxidase; Uric Acid | 1994 |
Relationship of oxypurine release to contractile failure in dinitrophenol-treated rat skeletal muscle.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Dinitrophenols; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Male; Muscle Contraction; Muscles; Phosphocreatine; Purines; Rats; Rats, Sprague-Dawley; Uncoupling Agents; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1993 |
Effect of DL-sodium lactate infusion on excretion of purine bases and oxypurinol.
Topics: Adult; Allopurinol; Humans; Hypoxanthine; Hypoxanthines; Lactates; Lactic Acid; Male; Oxypurinol; Purines; Serum Albumin; Uric Acid; Xanthine; Xanthines | 1993 |
Efficiency of hemodialysis of pyrimidine compounds in patients with chronic renal failure.
Topics: Adult; Aged; Allopurinol; Creatinine; Female; Half-Life; Humans; Kidney Failure, Chronic; Male; Middle Aged; Orotic Acid; Pseudouridine; Pyrimidines; Renal Dialysis; Uric Acid; Uridine | 1993 |
Acute gouty arthritis. Modern approaches to an ancient disease.
Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Humans; Indomethacin; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 1993 |
Nasal secretion of the ozone scavenger uric acid.
Topics: Albumins; Antioxidants; Humans; Lactoferrin; Methacholine Chloride; Muramidase; Nasal Mucosa; Nasal Provocation Tests; Ozone; Plasma; Probenecid; Turbinates; Uric Acid; Xanthine Oxidase | 1993 |
Mechanisms of adenine nucleotide depletion from endothelial cells exposed to reactive oxygen metabolites.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Endothelium, Vascular; Humans; Hydrogen Peroxide; Hypoxanthine; Hypoxanthines; Inosine; Reactive Oxygen Species; Superoxides; Umbilical Veins; Uric Acid; Xanthine Oxidase | 1993 |
Role of xanthine oxidase in reperfusion injury of ischemic skeletal muscles in the pig and human.
Topics: Adult; Allopurinol; Animals; Blood Cell Count; Chromatography, High Pressure Liquid; Female; Humans; Hypoxanthines; Male; Mechlorethamine; Muscles; Necrosis; Neutrophils; Orchiectomy; Oxypurinol; Peroxidase; Reactive Oxygen Species; Reperfusion Injury; Swine; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthines | 1993 |
Kinetic determination of serum adenosine deaminase.
Topics: 2,6-Dichloroindophenol; Adenosine; Adenosine Deaminase; Autoanalysis; Humans; Hypoxanthine; Hypoxanthines; Kinetics; Pentosyltransferases; Reference Values; Spectrophotometry; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1993 |
Effect of lactate infusion on renal transport of purine bases and oxypurinol.
Topics: Adult; Allopurinol; Biological Transport, Active; Humans; Hypoxanthine; Hypoxanthines; Infusions, Intravenous; Kidney; Lactates; Lactic Acid; Male; Oxypurinol; Purines; Serum Albumin; Uric Acid; Xanthine; Xanthines | 1993 |
Missed diagnosis of acute arthritic gout in kidney transplant recipients.
Topics: Acute Disease; Adult; Allopurinol; Arthritis, Gouty; Colchicine; Female; Humans; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Uric Acid | 1993 |
Allopurinol and oxypurinol in human breast milk.
Topics: Adult; Allopurinol; Female; Humans; Infant, Newborn; Male; Milk, Human; Oxypurinol; Pregnancy; Pregnancy Complications; Puerperal Disorders; Pyelonephritis; Uric Acid | 1993 |
Gout: modern management of an ancient malady.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Arthritis, Infectious; Gout; Humans; Uric Acid | 1993 |
Effects of the specific angiotensin II receptor antagonist losartan on urate homeostasis and intestinal urate transport.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biological Transport; Biphenyl Compounds; Chlorides; Colon; Homeostasis; Imidazoles; Intestinal Absorption; Kidney; Kidney Failure, Chronic; Losartan; Male; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tetrazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase | 1996 |
Effect of chronic experimental renal insufficiency on urate metabolism.
Topics: Animals; Erythropoietin; Intestinal Mucosa; Kidney; Kidney Failure, Chronic; Liver; Male; Nephrectomy; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Urate Oxidase; Uremia; Uric Acid; Xanthine Oxidase | 1995 |
Vincristine resistant HL-60 cells show cross-resistance to hypoxanthine-xanthine oxidase.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Hypoxanthine; Hypoxanthines; Reactive Oxygen Species; Uric Acid; Vincristine; Xanthine Oxidase | 1996 |
[Diagnosis and treatment of gout: not always simple].
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Arthritis, Rheumatoid; Biopsy; Colchicine; Diagnosis, Differential; Female; Gout; Gout Suppressants; Humans; Synovial Fluid; Uric Acid | 1996 |
Evidence favoring molybdenum-carbon bond formation in xanthine oxidase action: 17Q- and 13C-ENDOR and kinetic studies.
Topics: Animals; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metalloproteins; Milk; Models, Chemical; Molybdenum; Oxygen Isotopes; Oxypurinol; Uric Acid; Xanthine Oxidase | 1996 |
Accumulation of uric acid in plasma after repeated bouts of exercise in the horse.
Topics: Animals; Female; Horses; Lactic Acid; Male; Physical Conditioning, Animal; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 1996 |
Urinary excretion of purine derivatives and tissue xanthine oxidase (EC 1.2.3.2) activity in buffaloes (Bubalis bubalis) with special reference to differences between buffaloes and Bos taurus cattle.
Topics: Allantoin; Animals; Buffaloes; Cattle; Creatinine; Dietary Fiber; Fasting; Female; Intestinal Mucosa; Liver; Purines; Sheep; Species Specificity; Uric Acid; Xanthine Oxidase | 1996 |
Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Ethanol; Glycogen Storage Disease Type I; Gout; Heparin; Hepatitis C; Humans; Hydrogen-Ion Concentration; Hypoxanthine; Pterins; Spectrometry, Fluorescence; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines; Xanthopterin | 1996 |
Xanthine oxidase activity in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease.
Topics: Adult; Aged; Aged, 80 and over; Bronchoalveolar Lavage Fluid; Cytochrome c Group; DNA; DNA Damage; Female; Humans; Kinetics; Lung Diseases, Obstructive; Male; Middle Aged; Mutagens; Oxidation-Reduction; Spectrometry, Fluorescence; Superoxides; Uric Acid; Xanthine Oxidase | 1996 |
Allopurinol treatment results in elevated prostate-specific antigen levels in prostatic fluid and serum of patients with non-bacterial prostatitis.
Topics: Adult; Age Factors; Allopurinol; Body Fluids; Double-Blind Method; Enzyme Inhibitors; Humans; Male; Middle Aged; Prostate-Specific Antigen; Prostatitis; Uric Acid | 1996 |
A pilot study of blood antioxidant and free radical marker profiles in patients awaiting coronary artery bypass grafting.
Topics: Adult; Aged; Allopurinol; Antioxidants; Biomarkers; Coronary Artery Bypass; Free Radicals; Humans; Male; Middle Aged; Pilot Projects; Uric Acid | 1996 |
Combined deficiency of xanthine oxidase and sulphite oxidase due to a deficiency of molybdenum cofactor.
Topics: Coenzymes; Female; Fibroblasts; Humans; Hypoxanthine; Infant; Metabolism, Inborn Errors; Metalloproteins; Molybdenum; Molybdenum Cofactors; Nervous System Diseases; Oxidoreductases Acting on Sulfur Group Donors; Pteridines; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1996 |
Xanthine oxidase activity is not increased in the colonic mucosa of ulcerative colitis.
Topics: Biopsy; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Cysteine; Cystine; Humans; Intestinal Mucosa; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1996 |
Allopurinol, an inhibitor of xanthine oxidase, reduces uric acid levels and modifies the signs associated with copper deficiency in rats fed fructose.
Topics: Allopurinol; Animals; Copper; Diet; Enzyme Inhibitors; Free Radicals; Fructose; Heart; Lipid Peroxidation; Liver; Male; Pancreas; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 1996 |
Uric acid, xanthine oxidase and other risk factors of hypertension in normotensive subjects.
Topics: Adult; Female; Humans; Hypertension; Male; Middle Aged; Risk Factors; Uric Acid; Xanthine Oxidase | 1996 |
Identification of uric acid in aortic aneurysms and atherosclerotic artery.
Topics: Adult; Aged; Aortic Aneurysm, Abdominal; Arteriosclerosis; Carotid Stenosis; Chromatography, High Pressure Liquid; Humans; Middle Aged; Uric Acid; Xanthine Oxidase | 1996 |
[A study of serum oxipurinol concentration and renal function in patients administered allopurinol].
Topics: Adult; Aged; Allopurinol; Antimetabolites; Drug Administration Schedule; Female; Humans; Kidney; Male; Middle Aged; Oxypurinol; Renal Insufficiency; Uric Acid | 1996 |
Possible association of xanthine dehydrogenase/xanthine oxidase activity with nitric oxide in vivo.
Topics: Female; Gestational Age; Humans; Infant, Newborn; Male; Nitrates; Nitric Oxide; Nitrites; Respiratory Distress Syndrome, Newborn; Spectrophotometry; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1997 |
Antioxidant levels in the nasal mucosa of patients with chronic sinusitis and healthy controls.
Topics: Case-Control Studies; Chronic Disease; Female; Glutathione; Humans; Male; Middle Aged; Nasal Mucosa; Oxidative Stress; Sinusitis; Uric Acid; Vitamin E; Xanthine Oxidase | 1997 |
Assessment of xanthine oxidase in human lung and lung transplantation.
Topics: Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Free Radicals; Heart-Lung Transplantation; Humans; Hypoxanthine; Lactoferrin; Lung; Lung Transplantation; Middle Aged; Postoperative Complications; Reperfusion Injury; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Acceleration of hypertensive cerebral injury by the inhibition of xanthine-xanthine oxidase system in stroke-prone spontaneously hypertensive rats.
Topics: Allopurinol; Amitrole; Animals; Brain; Catalase; Cerebral Cortex; Cerebrovascular Disorders; Enzyme Inhibitors; Genetic Predisposition to Disease; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
Superoxide-dependent peroxidase activity of H48Q: a superoxide dismutase variant associated with familial amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Binding Sites; Cloning, Molecular; Copper; Cytochrome c Group; Escherichia coli; Hydrogen Peroxide; Mutation; Oxidation-Reduction; Recombinant Proteins; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase | 1997 |
Direct induction of acute lung and myocardial dysfunction by liver ischemia and reperfusion.
Topics: Acute Disease; Animals; Heart Diseases; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Lung Diseases; Male; Myocardial Contraction; Rats; Rats, Wistar; Reperfusion Injury; Uric Acid; Xanthine Oxidase | 1997 |
Effects of allopurinol on striatal dopamine, ascorbate and uric acid during an acute morphine challenge: ex vivo and in vivo studies.
Topics: Allopurinol; Animals; Ascorbic Acid; Corpus Striatum; Dopamine; Enzyme Inhibitors; Male; Microdialysis; Morphine; Rats; Rats, Wistar; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 1997 |
Gout due to xanthine derivatives.
Topics: Allopurinol; Aminophylline; Asthma; Benzbromarone; Bronchodilator Agents; Drug Therapy, Combination; Female; Gout; Humans; Middle Aged; Probenecid; Theophylline; Uric Acid; Uricosuric Agents | 1997 |
Serum urate during bouts of acute gouty arthritis.
Topics: Acute Disease; Allopurinol; Arthritis, Gouty; Gout Suppressants; Humans; Male; Prospective Studies; Retrospective Studies; Uric Acid | 1997 |
Hematuria due to hyperuricosuria in children: 36-month follow-up.
Topics: Adolescent; Allopurinol; Calcium; Child; Child, Preschool; Female; Follow-Up Studies; Hematuria; Humans; Kidney Calculi; Male; Potassium Citrate; Uric Acid | 1997 |
[Treatment of asymptomatic hyperuricemia].
Topics: Allopurinol; Dose-Response Relationship, Drug; Drug Administration Schedule; Gout; Gout Suppressants; Humans; Uric Acid | 1997 |
Oxidative stress induced by bloodless limb surgery on humans.
Topics: Aged; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Glutathione; Hemoglobins; Humans; Hypoxanthine; Knee; Oxidation-Reduction; Oxidative Stress; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 1997 |
Dietary L-arginine prevents fetal growth restriction in rats.
Topics: Animals; Arginine; Atmospheric Pressure; Diet; Embryonic and Fetal Development; Endothelins; Female; Fetal Growth Retardation; Glycine; Hypoxia; Nitric Oxide; Pregnancy; Rats; Rats, Wistar; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1998 |
Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout.
Topics: Adult; Allopurinol; Benzbromarone; Calcifediol; Calcitriol; Calcium; Gout; Gout Suppressants; Humans; Male; Middle Aged; Parathyroid Hormone; Phosphates; Reference Values; Uric Acid; Uricosuric Agents | 1998 |
Successful desensitization of a fixed drug eruption caused by allopurinol.
Topics: Allopurinol; Desensitization, Immunologic; Drug Hypersensitivity; Gout Suppressants; Humans; Male; Middle Aged; Uric Acid | 1998 |
Free radical-scavenging properties of lignin.
Topics: Animals; Dietary Fiber; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Glucosephosphate Dehydrogenase; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydroxyl Radical; Lignin; Lipid Peroxidation; Methylphenazonium Methosulfate; NAD; Nitroblue Tetrazolium; Rats; Rats, Wistar; Superoxides; Uric Acid; Xanthine Oxidase | 1998 |
Two siblings with classical xanthinuria type 1: significance of allopurinol loading test.
Topics: Adult; Allopurinol; Humans; Male; Mutation; Oxypurinol; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid; Xanthine Dehydrogenase; Xanthines | 1998 |
Disease-specific noncompliance with drug treatment as a cause of persistent hyperuricemia and gout in anorexia nervosa.
Topics: Allopurinol; Anorexia Nervosa; Female; Gout; Humans; Middle Aged; Patient Compliance; Treatment Failure; Uric Acid; Vomiting | 1998 |
Improved glycemic control in a diabetic patient after discontinuation of allopurinol administration.
Topics: Allopurinol; Blood Glucose; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycosuria; Gout Suppressants; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Uric Acid | 1998 |
Circulating xanthine oxidase and neutrophil activation during human liver transplantation.
Topics: Adult; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoxanthine; Intraoperative Period; Lactoferrin; Liver Circulation; Liver Transplantation; Male; Middle Aged; Neutrophil Activation; Postoperative Period; Reperfusion; Uric Acid; Xanthine; Xanthine Oxidase | 1998 |
Efficacy of allopurinol in ameliorating the progressive renal disease in familial juvenile hyperuricaemic nephropathy (FJHN). A six-year update.
Topics: Adolescent; Adult; Allopurinol; Child; Child, Preschool; Female; Follow-Up Studies; Gout Suppressants; Humans; Kidney Diseases; Male; Pedigree; Purine-Pyrimidine Metabolism, Inborn Errors; Time Factors; Uric Acid | 1998 |
How should we treat tophaceous gout in patients with allopurinol hypersensitivity?
Topics: Adolescent; Adult; Aged; Allopurinol; Benzbromarone; Creatinine; Drug Hypersensitivity; Gout; Gout Suppressants; Humans; Hypoxanthine Phosphoribosyltransferase; Kidney Failure, Chronic; Male; Middle Aged; Purine-Pyrimidine Metabolism, Inborn Errors; Uric Acid | 1998 |
Severe debilitating polyarticular gout and terminal renal failure in an allopurinol 'non-responder'.
Topics: Adult; Allopurinol; Arthritis, Gouty; Combined Modality Therapy; Drug Resistance; Fatal Outcome; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Renal Dialysis; Uric Acid | 1998 |
Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout.
Topics: Allopurinol; Calcifediol; Calcitriol; Gout; Gout Suppressants; Humans; Male; Middle Aged; Parathyroid Hormone; Reference Values; Uric Acid | 1998 |
Urinary excretion of purine derivatives as an index of microbial-nitrogen intake in growing rabbits.
Topics: Allantoin; Analysis of Variance; Animals; Bacteria; Duodenum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Kidney; Liver; Male; Nitrogen; Purines; Rabbits; Uric Acid; Xanthine Oxidase | 1998 |
Xanthine oxidase reaction with nitric oxide and peroxynitrite.
Topics: Animals; Blood Proteins; Catalase; Cattle; Cells, Cultured; Endothelium, Vascular; Free Radicals; Glutathione; In Vitro Techniques; Nitrates; Nitric Oxide; Nitroso Compounds; Oxidants; S-Nitrosoglutathione; Uric Acid; Xanthine; Xanthine Oxidase | 1998 |
Treatment of gout after transplantation.
Topics: Allopurinol; Azathioprine; Cyclosporine; Diuretics; Drug Interactions; Furosemide; Gout; Gout Suppressants; Heart Transplantation; Humans; Postoperative Complications; Uric Acid | 1998 |
Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cacao; Chromatography, High Pressure Liquid; Cimetidine; Dose-Response Relationship, Drug; Ethanol; Flavonoids; Gastric Mucosa; Lipid Peroxidation; Male; Peroxidase; Phenols; Polymers; Polyphenols; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sucralfate; Thiobarbituric Acid Reactive Substances; Uric Acid; Vitamin E; Xanthine Oxidase | 1998 |
[Hereditary xanthinuria, rare cause of hypo-uric acidemia. 2 cases].
Topics: Adult; Aged; Chromosome Aberrations; Chromosome Disorders; Female; Genes, Recessive; Humans; Kidney Calculi; Male; Metabolism, Inborn Errors; Uric Acid; Xanthine; Xanthine Oxidase | 1998 |
Neuroprotection against oxidative stress by serum from heat acclimated rats.
Topics: Acclimatization; Animals; Blood Physiological Phenomena; Cell Survival; Hot Temperature; Male; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Rats, Inbred Strains; Reference Values; Uric Acid; Xanthine Oxidase | 1998 |
Serum uric acid in acute gout.
Topics: Acute Disease; Allopurinol; Gout; Gout Suppressants; Humans; Uric Acid | 1998 |
Xanthine urolithiasis in a dachshund.
Topics: Animals; Dog Diseases; Dogs; Male; Uric Acid; Urinary Calculi; Xanthine; Xanthine Oxidase | 1998 |
Hypercapnic acidosis may attenuate acute lung injury by inhibition of endogenous xanthine oxidase.
Topics: Acidosis; Analysis of Variance; Animals; Blood Pressure; Capillaries; Capillary Permeability; Carbon Dioxide; Free Radicals; Hydrostatic Pressure; Hypercapnia; Lung; Male; Microcirculation; Nitric Oxide Synthase; Pulmonary Artery; Purines; Rabbits; Reperfusion Injury; Respiration, Artificial; Respiratory Distress Syndrome; Uric Acid; Vascular Resistance; Xanthine Oxidase | 1998 |
Inhibition of xanthine oxidase by pterins.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Edetic Acid; Ferric Compounds; Formazans; Hydrogen-Ion Concentration; Nitroblue Tetrazolium; Oxidation-Reduction; Pterins; Spectrophotometry, Ultraviolet; Superoxide Dismutase; Superoxides; Time Factors; Uric Acid; Xanthine; Xanthine Oxidase | 1998 |
Hyperuricaemia and congestive heart failure: causation or association?
Topics: Heart Failure; Humans; Uric Acid; Xanthine Oxidase | 1998 |
Uric acid in chronic heart failure: a marker of chronic inflammation.
Topics: Cardiomyopathy, Dilated; Case-Control Studies; Coronary Disease; Cytokines; Glucose Tolerance Test; Heart Failure; Humans; Linear Models; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 1998 |
Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities.
Topics: Allopurinol; Arylamine N-Acetyltransferase; Biomarkers; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Female; Humans; Male; Oxypurinol; Prospective Studies; Uric Acid; Xanthine Oxidase | 1999 |
[Gout: physiopathology, diagnosis, course, treatment].
Topics: Adult; Aged; Allopurinol; Arthritis, Gouty; Benzbromarone; Diagnosis, Differential; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Probenecid; Synovial Fluid; Uric Acid; Uricosuric Agents | 1998 |
Pulmonary xanthine oxidase activity of rats exposed to prolonged immobilization stress.
Topics: Animals; Immobilization; Lipid Peroxidation; Lung; Male; Rats; Rats, Wistar; Stress, Physiological; Time Factors; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1998 |
Anti-Trypanosoma brucei activity of nonprimate zoo sera.
Topics: Animals; Animals, Zoo; Antelopes; Antibodies, Protozoan; Artiodactyla; Buffaloes; Carnivora; Complement System Proteins; Culture Media; Hot Temperature; Hydrogen Peroxide; Immune Sera; Swine; Trypanosoma brucei brucei; Trypanosomiasis, African; Uric Acid; Xanthine Oxidase | 1999 |
Role of xanthine oxidase in delayed lipid peroxidation in rat liver induced by acute exhausting exercise.
Topics: Allopurinol; Animals; Enzyme Inhibitors; Female; Hypoxanthine; Lipid Peroxidation; Liver; Oxidative Stress; Physical Exertion; Rats; Rats, Wistar; Running; Thiobarbituric Acid Reactive Substances; Uric Acid; Xanthine Oxidase | 1999 |
Nigrostriatal catecholamine metabolism in guinea pigs is altered by purine enzyme inhibition.
Topics: 3,4-Dihydroxyphenylacetic Acid; Allopurinol; Animals; Catecholamines; Corpus Striatum; Dopamine; Enzyme Inhibitors; Guinea Pigs; Injections; Male; Norepinephrine; Oxonic Acid; Substantia Nigra; Uric Acid | 1999 |
The survival of skeletal muscle myoblasts in vitro is sensitive to a donor of nitric oxide and superoxide, SIN-1, but not to nitric oxide or peroxynitrite alone.
Topics: Animals; Cell Line; Cell Survival; Molsidomine; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxyhemoglobins; Rats; Superoxide Dismutase; Superoxides; Uric Acid; Xanthine Oxidase | 1999 |
Role of the midgut gland in purine excretion in the robber crab, Birgus latro (Anomura: Coenobitidae).
Topics: Animals; Brachyura; Catalase; Digestive System; Digestive System Physiological Phenomena; Enzyme Activation; Feces; Microbodies; Microscopy, Electron; Phenylmethylsulfonyl Fluoride; Purines; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 1999 |
Effect of ischemia-reperfusion on xanthine oxidase activity in fetal rat brain capillaries.
Topics: Animals; Arteries; Brain; Capillaries; Constriction; Female; Fetus; Hypoxanthine; Ischemia; Ovary; Pregnancy; Rats; Rats, Wistar; Reperfusion; Thiobarbituric Acid Reactive Substances; Uric Acid; Uterus; Xanthine; Xanthine Oxidase | 1999 |
Purification and partial characterization of caffeine oxidase--A novel enzyme from a mixed culture consortium.
Topics: Caffeine; Klebsiella; Oxidation-Reduction; Oxygenases; Rhodococcus; Substrate Specificity; Theobromine; Theophylline; Uric Acid; Xanthine Oxidase | 1999 |
Gout.
Topics: Acute Disease; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Crystallization; Fatal Outcome; Glucocorticoids; Gout; Gout Suppressants; Humans; Male; Neural Tube Defects; Synovial Fluid; Uric Acid | 1999 |
The caffeine metabolic ratio as an index of xanthine oxidase activity in clinically active and silent celiac patients.
Topics: Caffeine; Celiac Disease; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Iron; Male; Uric Acid; Xanthine Oxidase; Xanthines | 1999 |
Pharmacokinetics and pharmacodynamics of allopurinol in elderly and young subjects.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Allopurinol; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Hypoxanthine; Male; Oxypurinol; Time Factors; Uric Acid; Xanthine | 1999 |
A comparative study on the hypouricemic activity and potency in renal xanthine calculus formation of two xanthine oxidase/xanthine dehydrogenase inhibitors: TEI-6720 and allopurinol in rats.
Topics: Allantoin; Allopurinol; Animals; Enzyme Inhibitors; Febuxostat; Kidney Calculi; Male; Rats; Rats, Inbred Strains; Thiazoles; Uric Acid; Xanthine; Xanthine Oxidase | 1999 |
Uric acid nephropathy as an unusual cause of actual renal failure in a neonate.
Topics: Acute Kidney Injury; Allopurinol; Gout Suppressants; Humans; Infant, Newborn; Male; Renal Dialysis; Uric Acid | 2000 |
Modification of oxidative stress in response to intestinal preconditioning.
Topics: Animals; Glutathione; Intestinal Mucosa; Intestines; Ischemic Preconditioning; Lipid Peroxides; Male; Oxidative Stress; Rats; Rats, Wistar; Reference Values; Reperfusion; Uric Acid; Xanthine; Xanthine Oxidase | 2000 |
Allopurinol: intravenous use for prevention and treatment of hyperuricemia.
Topics: Adult; Allopurinol; Child; Enzyme Inhibitors; Humans; Infusions, Intravenous; Kidney Diseases; Neoplasms; Tumor Lysis Syndrome; Uric Acid; Xanthine Oxidase | 2000 |
Reduction of organic nitrites to nitric oxide catalyzed by xanthine oxidase: possible role in metabolism of nitrovasodilators.
Topics: Animals; Biotransformation; Cattle; Kinetics; Milk; Nitric Oxide; Nitrites; Uric Acid; Vasodilator Agents; Xanthine Oxidase | 2000 |
N-Hydroxyguanidine compound 1-(3,4-dimethoxy- 2-chlorobenzylideneamino)-3-hydroxyguanidine inhibits the xanthine oxidase mediated generation of superoxide radical.
Topics: Allopurinol; Animals; Binding Sites; Catalysis; Cattle; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Guanidines; Hydroxylamines; Inhibitory Concentration 50; Kinetics; Milk; Models, Chemical; Molybdenum; NAD; Onium Compounds; Oxidation-Reduction; Oxygen; Reperfusion Injury; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase | 2000 |
The effects of allopurinol on immune function in normal BALB/c and SCID mice.
Topics: Allopurinol; Animals; Immune System; Immunoglobulin G; Immunoglobulins; Lymphocyte Count; Lymphocyte Subsets; Mice; Mice, Inbred BALB C; Mice, SCID; Ovalbumin; Uric Acid | 2000 |
Interaction of hypoxanthine/xanthine oxidase with nitrergic relaxation in the porcine gastric fundus.
Topics: Animals; Antioxidants; Free Radical Scavengers; Gastric Fundus; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Swine; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2000 |
[Purine metabolism enzymes in diagnosis and differential diagnosis of osteoarthritis and gout arthritis].
Topics: 5'-Nucleotidase; Arthritis, Gouty; Biomarkers; Diagnosis, Differential; Female; Humans; Isoenzymes; Male; Middle Aged; Osteoarthritis; Purines; Severity of Illness Index; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2000 |
The optimal use of allopurinol: an audit of allopurinol use in South Auckland.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Creatinine; Drug Evaluation; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; New Zealand; Oxypurinol; Uric Acid | 2000 |
Sulfinpyrazone reduces cyclosporine levels: a new drug interaction in heart transplant recipients.
Topics: Allopurinol; Creatinine; Cyclosporine; Drug Interactions; Female; Follow-Up Studies; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Male; Middle Aged; Risk Factors; Sulfinpyrazone; Urea; Uric Acid; Uricosuric Agents | 2000 |
Comparison between xanthine oxidases from buttermilk and microorganisms regarding their ability to generate reactive oxygen species.
Topics: Animals; Bacteria; Hydrogen Peroxide; Kinetics; Milk; Oxygen; Reactive Oxygen Species; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase | 2001 |
Tumor lysis syndrome in an infant with Langerhans cell histiocytosis successfully treated using continuous arteriovenous hemofiltration.
Topics: Acute Kidney Injury; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Blood Transfusion; Combined Modality Therapy; Disease Progression; Etoposide; Fatal Outcome; Female; Fluid Therapy; Hemofiltration; Histiocytosis, Langerhans-Cell; Humans; Infant; L-Lactate Dehydrogenase; Lymph Nodes; Mercaptopurine; Multiple Organ Failure; Neck; Orbital Diseases; Prednisolone; Sodium Bicarbonate; Temporal Bone; Tumor Lysis Syndrome; Uric Acid; Vinblastine; Vincristine | 2001 |
Purine nucleotide catabolism in rat liver: labelling of uric acid and allantoin after treatment with oxonic acid and allopurinol.
Topics: Allantoin; Allopurinol; Animals; Enzyme Inhibitors; Liver; Male; Oxonic Acid; Purine Nucleotides; Rats; Rats, Wistar; Uric Acid | 2001 |
Dehydroascorbic acid and oxidative stress in haemodialysis patients.
Topics: Aging; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Case-Control Studies; Dehydroascorbic Acid; Female; Humans; Kidney Failure, Chronic; Lipid Peroxides; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Reference Values; Renal Dialysis; Uric Acid | 2001 |
Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.
Topics: Allopurinol; Animals; Area Under Curve; Gout; Gout Suppressants; Male; Metabolic Diseases; Models, Animal; Pyrazoles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2001 |
Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts.
Topics: Animals; Antimycin A; Antioxidants; Cytochrome b Group; Electron Spin Resonance Spectroscopy; Electron Transport Complex III; Heart; In Vitro Techniques; Kinetics; Liposomes; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Oxidation-Reduction; Oxygen; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Succinic Acid; Superoxides; Uric Acid; Vitamin E; Xanthine Oxidase | 2001 |
Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Flow Velocity; Blood Pressure; Cachexia; Confidence Intervals; Heart Failure; Humans; Leg; Middle Aged; Severity of Illness Index; Uric Acid; Vascular Resistance; Xanthine Oxidase | 2001 |
The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers.
Topics: Adrenergic alpha-Antagonists; Aged; AMP Deaminase; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Enzyme Activation; Female; Humans; Hypertension; Hypoxanthine; Male; Middle Aged; Muscle, Skeletal; Substrate Specificity; Uric Acid; Xanthine Oxidase | 2001 |
Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis.
Topics: Allopurinol; Animals; Cerebral Cortex; Cyclic N-Oxides; Enzyme Inhibitors; Free Radical Scavengers; Meningitis, Pneumococcal; Nitrogen Oxides; Oxidoreductases; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2001 |
[Therapeutic criteria in hyperuricemia].
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Colchicine; Gout; Gout Suppressants; Humans; Uric Acid; Uricosuric Agents | 2001 |
Regulation of free radical processes by delta-sleep inducing peptide in rat tissues under cold stress.
Topics: Animals; Antioxidants; Brain; Catalase; Ceruloplasmin; Cholesterol; Cold Temperature; Delta Sleep-Inducing Peptide; Erythrocytes; Free Radicals; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Liver; Male; Oxidation-Reduction; Peroxidase; Rats; Superoxide Dismutase; Urea; Uric Acid; Xanthine Oxidase | 2001 |
Accelerated tissue aging and increased oxidative stress in broiler chickens fed allopurinol.
Topics: Aging; Allopurinol; Animals; Antimetabolites; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Glycation End Products, Advanced; Glycosylation; Hemin; Luminescent Measurements; Lysine; Muscle, Skeletal; Oxidative Stress; Skin; Uric Acid | 2001 |
Identification of uric acid and xanthine oxidase in atherosclerotic plaque.
Topics: Adult; Aged; Cadaver; Carotid Arteries; Carotid Artery Diseases; Case-Control Studies; Endarterectomy, Carotid; Humans; Intracranial Arteriosclerosis; Middle Aged; Uric Acid; Xanthine Oxidase | 2001 |
Uric acid or urate nephropathy?
Topics: Allopurinol; Azathioprine; Biopsy; Diagnosis, Differential; Drug Interactions; Humans; Kidney; Kidney Diseases; Mycophenolic Acid; Uric Acid | 2001 |
The effect of allopurinol on focal cerebral ischaemia: an experimental study in rabbits.
Topics: Allopurinol; Animals; Blood Gas Analysis; Blood Glucose; Brain Ischemia; Chromatography, High Pressure Liquid; Disease Models, Animal; Free Radical Scavengers; Hematocrit; Hemoglobins; Hypoxanthine; Infarction, Middle Cerebral Artery; Rabbits; Uric Acid; Xanthine; Xanthine Oxidase | 2001 |
Ischemia/reperfusion injury of rat small intestine: the effect of allopurinol dosage.
Topics: Administration, Oral; Allopurinol; Analysis of Variance; Animals; Antioxidants; Free Radical Scavengers; Injections, Intraperitoneal; Intestinal Mucosa; Intestine, Small; Leukocyte Count; Lipid Peroxidation; Malondialdehyde; Rats; Rats, Wistar; Regression Analysis; Reperfusion Injury; Thiobarbituric Acid Reactive Substances; Uric Acid | 2001 |
[Familial gout and nephropathy in a young woman. Report of one case].
Topics: Adult; Allopurinol; Female; Genetic Counseling; Gout; Gout Suppressants; Humans; Kidney Diseases; Uric Acid | 2001 |
[Determination of caffeine metabolite for the evaluation of N-acetyltransferase, CYP1A2 and xanthine oxidase activities].
Topics: Adolescent; Adult; Aged; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines | 1997 |
Inhibitory effects of methylxanthines on the pre-eclamptic-like symptoms in ewes.
Topics: Albumins; Allopurinol; Animals; Bilirubin; Blood Pressure; Fasting; Female; Heme; Hypertension; Hypoxanthine; Kidney; Liver; Pentoxifylline; Platelet Count; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Sheep; Uric Acid; Xanthine | 2001 |
Effects of flavonols on the generation of superoxide anion radicals by xanthine oxidase and stimulated neutrophils.
Topics: Cytochrome c Group; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Firefly Luciferin; Flavonoids; Flavonols; Free Radical Scavengers; Humans; Isoenzymes; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Respiratory Burst; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase | 2001 |
Urate oxidase in the prophylaxis or treatment of hyperuricemia: the United States experience.
Topics: Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Child; Clinical Trials as Topic; Female; Hematologic Neoplasms; Humans; Male; Retrospective Studies; Therapeutic Equivalency; Tumor Lysis Syndrome; United States; Urate Oxidase; Uric Acid | 2001 |
Xanthine oxidase catalyzes the synthesis of retinoic acid.
Topics: Animals; Chromatography, High Pressure Liquid; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Milk; Molecular Conformation; NAD; Oxygen; Retinaldehyde; Tretinoin; Uric Acid; Xanthine; Xanthine Oxidase | 2001 |
[Hypersensitivity syndrome during therapy with allopurinol in asymptomatic hyperuricemia with a fatal outcome].
Topics: Aged; Aged, 80 and over; Allopurinol; Antimetabolites; Drug Hypersensitivity; Fatal Outcome; Female; Humans; Stevens-Johnson Syndrome; Uric Acid | 2001 |
Hyperuricemia, gout, and renal function after liver transplantation.
Topics: Adult; Aged; Allopurinol; Creatinine; Female; Gout; Humans; Kidney; Liver Transplantation; Male; Middle Aged; Retrospective Studies; Uric Acid | 2001 |
Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow.
Topics: Animals; Biotransformation; Capillaries; Hindlimb; Hyperinsulinism; Infusions, Intravenous; Insulin; Kinetics; Male; Microcirculation; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Uric Acid; Xanthine Oxidase; Xanthines | 2002 |
Therapeutic efficacy of allopurinol in mania associated with hyperuricemia.
Topics: Adult; Allopurinol; Bipolar Disorder; Enzyme Inhibitors; Female; Humans; Male; Treatment Outcome; Uric Acid | 2001 |
Effect of losartan and furosemide on the urinary excretion of oxypurinol and uric acid.
Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Proteins; Diuretics; Furosemide; Humans; Losartan; Male; Middle Aged; Oxypurinol; Uric Acid; Xanthine Oxidase | 2000 |
[Hyperuricemia and gout--treatment].
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Benzbromarone; Colchicine; Drug Therapy, Combination; Glucocorticoids; Gout; Gout Suppressants; Humans; Kidney Calculi; Kidney Diseases; Probenecid; Time Factors; Uric Acid; Uricosuric Agents | 2002 |
Aesculin possesses potent hypouricemic action in rodents but is devoid of xanthine oxidase/dehydrogenase inhibitory activity.
Topics: Allopurinol; Animals; Dose-Response Relationship, Drug; Esculin; Liver; Male; Mice; Mice, Inbred ICR; Models, Animal; Oleaceae; Oxonic Acid; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Time Factors; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2002 |
[How to treat hyperuricemia and gout attacks in compensated kidney failure?].
Topics: Aged; Aged, 80 and over; Allopurinol; Glucocorticoids; Gout; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Risk Factors; Time Factors; Uric Acid | 2002 |
Effect of urate on nitric oxide microcirculatory response in the rat tail to body heating.
Topics: Allopurinol; Animals; Blood Flow Velocity; Blood Pressure; Hot Temperature; Male; Microcirculation; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Stress, Physiological; Tail; Uric Acid; Vasodilation | 2002 |
Is it gout? Tap the joint!
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Glucocorticoids; Gout; Gout Suppressants; Humans; Synovial Fluid; Uric Acid | 2002 |
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arterioles; Benzofurans; Blood Pressure; Diuretics; Enalapril; Hydrochlorothiazide; Hypertension; Kidney; Losartan; Male; Muscle, Smooth, Vascular; Oxonic Acid; Rats; Rats, Sprague-Dawley; Sodium Chloride Symporter Inhibitors; Sodium Chloride, Dietary; Uric Acid; Uricosuric Agents; Vascular Diseases | 2002 |
Antioxidant activity of dodecyl gallate.
Topics: Animals; Antioxidants; Binding, Competitive; Enzyme Inhibitors; Erythrocytes; Gallic Acid; Humans; Kinetics; Lipid Peroxidation; Microsomes, Liver; Mitochondria; Oxidation-Reduction; Oxidative Stress; Rats; Superoxides; Uric Acid; Xanthine Oxidase | 2002 |
An in vitro hydroxyl radical generation assay for microdialysis sampling calibration.
Topics: Ascorbic Acid; Calibration; Chromatography, High Pressure Liquid; Hydroxybenzoates; Hydroxyl Radical; Hypoxanthine; Microdialysis; Uric Acid; Xanthine; Xanthine Oxidase | 2002 |
Iron regulates xanthine oxidase activity in the lung.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cricetinae; Cricetulus; Dust; Ferric Compounds; Iron; Lung; Male; Oxidoreductases; Rats; Rats, Sprague-Dawley; Silicon Dioxide; Trachea; Uric Acid; Xanthine Oxidase | 2002 |
Hyperuricemia and gout: a reign of complacency.
Topics: Allopurinol; Colchicine; Coronary Disease; Gout; Gout Suppressants; Humans; Kidney Failure, Chronic; Patient Care Planning; Uric Acid | 2002 |
A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test.
Topics: Adult; Arylamine N-Acetyltransferase; Asian People; Caffeine; Cytochrome P-450 CYP1A2; Female; Genotype; Humans; Japan; Male; Phenotype; Reference Values; Uric Acid; Xanthine Oxidase | 2002 |
Early treatment with allopurinol in familial juvenile hyerpuricaemic nephropathy (FJHN) ameliorates the long-term progression of renal disease.
Topics: Adolescent; Adult; Allopurinol; Child; Female; Follow-Up Studies; Gout Suppressants; Humans; Kidney Diseases; Male; Pedigree; Renal Insufficiency; Retrospective Studies; Syndrome; Treatment Outcome; Uremia; Uric Acid; Uricosuric Agents | 2002 |
2-styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study.
Topics: Animals; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Milk; Structure-Activity Relationship; Uric Acid; Xanthine; Xanthine Oxidase | 2002 |
Urate produced during hypoxia protects heart proteins from peroxynitrite-mediated protein nitration.
Topics: Animals; Ascorbic Acid; Brain; Heart; Hypoxanthine; Hypoxia; In Vitro Techniques; Myocardium; Nitric Oxide; Nitrosation; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Tyrosine; Urate Oxidase; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2002 |
Uric acid concentrations and the mechanisms of cardiovascular disease.
Topics: Allopurinol; Antimetabolites; Cardiovascular Diseases; Enzyme Inhibitors; Humans; Risk Factors; Urate Oxidase; Uric Acid | 2002 |
Metabolic abnormalities in lymphoma.
Topics: Adult; Allopurinol; Anthracyclines; Cell Division; Creatinine; Enzyme Inhibitors; Humans; Hypocalcemia; Hypophosphatemia; Lymphoma; Male; Renal Insufficiency; Time Factors; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2002 |
Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output.
Topics: Adult; Allopurinol; Case-Control Studies; Gout; Gout Suppressants; Humans; Hyperuricemia; Middle Aged; Uric Acid | 2002 |
Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density lipoprotein.
Topics: Antioxidants; Copper; Cytochrome c Group; Electrophoresis, Agar Gel; Garlic; Humans; Immunoblotting; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Lipoxygenase; Oxidation-Reduction; Plant Extracts; Superoxides; Thiobarbituric Acid Reactive Substances; Uric Acid; Xanthine; Xanthine Oxidase | 2003 |
Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology.
Topics: Adenosine Triphosphate; Heart Failure; Humans; Kidney; Nitric Oxide; Predictive Value of Tests; Prognosis; Purines; ROC Curve; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2003 |
Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging.
Topics: Biomarkers; Chronic Disease; Comorbidity; Female; Follow-Up Studies; Heart Failure; Hemodynamics; Humans; Hyperuricemia; Male; Middle Aged; Models, Statistical; Oxygen Consumption; Predictive Value of Tests; Prognosis; Risk Factors; ROC Curve; Sensitivity and Specificity; Stroke Volume; Survival Rate; Uric Acid; Xanthine Oxidase | 2003 |
Decrease in the total antioxidant activity of saliva in patients with periodontal diseases.
Topics: Adult; Albumins; Antioxidants; Ascorbic Acid; Electrolysis; Female; Free Radical Scavengers; Free Radicals; Humans; Male; Middle Aged; Neutrophil Activation; Periodontal Diseases; Saliva; Salivary Proteins and Peptides; Uric Acid; Xanthine; Xanthine Oxidase | 2003 |
[Enzymes of purine metabolism of lymphocytes and eosinophiles in bronchial asthma].
Topics: 5'-Nucleotidase; Adenosine Deaminase; Adolescent; Adult; Asthma; Eosinophils; Humans; Lymphocytes; Male; Middle Aged; Purines; Uric Acid; Xanthine Oxidase | 2003 |
Rush desensitization to allopurynol.
Topics: Adult; Allopurinol; Angioedema; Desensitization, Immunologic; Drug Administration Schedule; Drug Eruptions; Gout; Gout Suppressants; Humans; Male; Uric Acid; Urticaria | 2003 |
Protective effect of coadministered superoxide dismutase and catalase against stress-induced gastric mucosal lesions.
Topics: Animals; Antioxidants; Catalase; Gastric Mucosa; Peroxidase; Rats; Rats, Wistar; Stomach Ulcer; Stress, Psychological; Sulfhydryl Compounds; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Uric Acid; Xanthine Oxidase | 2003 |
[Oral chemolysis of uric acid stones].
Topics: Administration, Oral; Allopurinol; Citric Acid; Combined Modality Therapy; Drug Therapy, Combination; Humans; Hyperuricemia; Lithotripsy; Retrospective Studies; Treatment Outcome; Uric Acid; Urinary Calculi | 2003 |
Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Allopurinol; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Female; Mice; Mice, Inbred ICR; Oxypurinol; Reactive Oxygen Species; Streptozocin; Superoxides; Time Factors; Uric Acid; Xanthine Oxidase | 2003 |
Xanthine oxidase studies.
Topics: Oxidoreductases; Uric Acid; Xanthine Oxidase | 1952 |
[Studies on uric acid metabolism. 2. Effect of methylated xanthine derivatives on the activity of xanthine oxidase in vitro].
Topics: In Vitro Techniques; Oxidoreductases; Uric Acid; Xanthine Oxidase; Xanthines | 1953 |
[Uric acid and xanthine oxidase in seminal vesicles].
Topics: Humans; Male; Oxidoreductases; Seminal Vesicles; Uric Acid; Xanthine Oxidase | 1953 |
Studies on uric acid and related compounds. III. Observations on the specificity of mammalian xanthine oxidases.
Topics: Animals; Humans; Mammals; Oxidoreductases; Uric Acid; Xanthine Oxidase; Xanthines | 1956 |
Studies on uric acid and related compounds. IV. The specificity of bacterial xanthine oxidases.
Topics: Oxidoreductases; Pseudomonas; Uric Acid; Vibrio; Xanthine Oxidase | 1957 |
Steps in the oxidation of xanthine to uric acid catalysed by milk xanthine oxidase.
Topics: Animals; Catalysis; Milk; Oxidation-Reduction; Oxidoreductases; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 1959 |
EFFECTS OF HYPOXIA ON IRON ABSORPTION AND MOBILIZATION IN THE RAT.
Topics: Hemoglobins; Hypoxia; Intestinal Absorption; Iron; Iron Isotopes; Liver; Pharmacology; Rats; Research; Uric Acid; Xanthenes; Xanthine Oxidase | 1964 |
SIMILAR ACCUMULATION AND DISTRIBUTION PATTERNS OF TWO PURINE-OXIDIZING ENZYMES IN RANA CATESBEIANA DEVELOPMENT.
Topics: Animals; Anura; Embryo, Mammalian; Embryo, Nonmammalian; Gastrointestinal Tract; Humans; Kidney; Liver; Lung; Muscles; Purines; Rana catesbeiana; Research; Uric Acid; Xanthine Oxidase | 1964 |
4-HYDROXYPYRAZOLO (3,4-D) PYRIMIDINE (HPP) IN THE TREATMENT OF GOUT: PRELIMINARY OBSERVATIONS.
Topics: Blood; Colchicine; Diet; Diet Therapy; Drug Therapy; Enzyme Inhibitors; Geriatrics; Gout; Humans; Probenecid; Purines; Pyrazoles; Pyrimidines; Toxicology; Uric Acid; Urine; Xanthine Oxidase; Xanthines | 1964 |
CLINICAL, PHYSIOLOGICAL AND BIOCHEMICAL STUDIES OF A PATIENT WITH XANTHINURIA AND PHEOCHROMOCYTOMA.
Topics: Blood; Blood Group Antigens; Carbon Isotopes; Catecholamines; Electrophoresis; Humans; Jejunum; Kidney; Liver; Metabolism; Pheochromocytoma; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Urine; Xanthine Oxidase; Xanthines | 1964 |
EFFECT OF ALLOPURINOL (4-HYDROXYPYRAZOLO-(3,4-D)PYRIMIDINE) ON SERUM AND URINARY URIC ACID IN PRIMARY AND SECONDARY GOUT.
Topics: Allopurinol; Arthritis; Blood; Bone Marrow Diseases; Drug Therapy; Enzyme Inhibitors; Fluids and Secretions; Gout; Humans; Metabolism; Pharmacology; Polycythemia Vera; Pyrazoles; Pyrimidines; Toxicology; Uric Acid; Uricosuric Agents; Urinary Calculi; Urine; Xanthine Oxidase | 1964 |
PURIFICATION OF XANTHINE DEHYDROGENASE FROM DROSOPHILA MELANOGASTER.
Topics: Animals; Biochemical Phenomena; Biochemistry; Drosophila; Drosophila melanogaster; Hypoxanthines; Kinetics; NAD; Research; Spectrophotometry; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthines | 1964 |
THE EFFECTIVENESS OF THE XANTHINE OXIDASE INHIBITOR ALLOPURINOL IN THE TREATMENT OF GOUT.
Topics: Allopurinol; Blood Chemical Analysis; Drug Therapy; Enzyme Inhibitors; Gout; Humans; Metabolism; Purines; Pyrimidines; Toxicology; Uric Acid; Uricosuric Agents; Urine; Xanthine Oxidase | 1965 |
A SENSITIVE METHOD FOR THE DETERMINATION OF XANTHINE OXIDASE ACTIVITY.
Topics: Blood Chemical Analysis; Carbon Isotopes; Chemistry Techniques, Analytical; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Ion Exchange Resins; Oxidation-Reduction; Uric Acid; Xanthine Oxidase | 1965 |
PREVENTION OF HYPERURICEMIA IN LEUKEMIA AND LYMPHOMA: USE OF ALOPURINOL, A XANTHINE OXIDASE INHIBITOR.
Topics: Adolescent; Antineoplastic Agents; Blood; Blood Urea Nitrogen; Drug Therapy; Geriatrics; Humans; Hyperuricemia; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Metabolism; Neoplasms; Nitrogen; Pyrimidines; Sarcoma; Urea; Uric Acid; Uricosuric Agents; Urine; Xanthine Oxidase | 1965 |
THE STUDY OF PURINE UTILIZATION AND EXCRETION IN A XANTHINURIC MAN.
Topics: Adenine; Carbon Isotopes; Chromatography; Guanine; Humans; Hypoxanthines; Male; Metabolism, Inborn Errors; Nucleotides; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Spectrophotometry; Uric Acid; Urine; Xanthine Oxidase; Xanthines | 1965 |
THE USE OF ALLOPURINOL (HPP) TO CONTROL HYPERURICEMIA IN PATIENTS ON CHRONIC INTERMITTENT HEMODIALYSIS.
Topics: Allopurinol; Blood; Creatine; Creatinine; Drug Therapy; Glomerulonephritis; Humans; Hypertension; Hypertension, Malignant; Hyperuricemia; Kidney; Kidneys, Artificial; Pyrimidines; Renal Dialysis; Uric Acid; Uricosuric Agents | 1965 |
Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury.
Topics: Allopurinol; Animals; Antibodies, Monoclonal; Drug Evaluation, Preclinical; Ileum; Intercellular Adhesion Molecule-1; Intestines; Ischemia; Jejunum; Male; Methylene Blue; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tumor Necrosis Factor-alpha; Uric Acid | 2003 |
Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II.
Topics: Adult; Aldehyde Oxidase; Allopurinol; Antimetabolites; DNA Primers; DNA, Complementary; Duodenum; Female; Humans; Hypoxanthine; Immunoblotting; Intestinal Mucosa; Point Mutation; Purine-Pyrimidine Metabolism, Inborn Errors; Sulfurtransferases; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthines | 2003 |
Peroxynitrite delivery methods for toxicity studies.
Topics: Animals; Cells, Cultured; Dimerization; Drug Delivery Systems; Humans; Hypoxanthine; Models, Chemical; Nitrates; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Toxicity Tests; Tyrosine; Uric Acid; Xanthine Oxidase | 2004 |
[Distribution of xanthinoxidase in different species of birds. I. Presence of xanthinoxidase in the liver of different species of birds and the problem of uric acid synthesis in birds].
Topics: Animals; Birds; Liver; Oxidoreductases; Uric Acid; Xanthine Oxidase | 1952 |
2,8-Dihydroxyadenine renal stones in a 41-year-old man.
Topics: Adenine; Adenine Phosphoribosyltransferase; Adult; Allopurinol; Antimetabolites; Humans; Kidney Calculi; Male; Uric Acid | 2004 |
Peroxynitrite formation from the simultaneous reduction of nitrite and oxygen by xanthine oxidase.
Topics: Animals; Cattle; Enzyme Inhibitors; Milk; Nitric Oxide; Nitrites; Onium Compounds; Oxidation-Reduction; Oxygen; Peroxynitrous Acid; Rhodamines; Superoxide Dismutase; Uric Acid; Xanthine Oxidase | 2004 |
Characterization of xanthine oxidase inhibition by anacardic acids.
Topics: Anacardic Acids; Binding Sites; Enzyme Inhibitors; Flavin-Adenine Dinucleotide; Kinetics; Salicylates; Uric Acid; Xanthine; Xanthine Oxidase | 2004 |
Protective effects of exogenous fructose-1,6-biphosphate during small bowel transplantation in rats.
Topics: Adenosine; Adenosine Triphosphate; Allopurinol; Animals; Bacterial Translocation; Cryopreservation; Cytoprotection; Fructosediphosphates; Glutathione; Hypoxanthine; Insulin; Intestine, Small; Intestines; L-Lactate Dehydrogenase; Male; Organ Preservation Solutions; Oxidative Stress; Raffinose; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Uric Acid; Xanthine | 2004 |
Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice.
Topics: Allopurinol; Animals; Antioxidants; Biflavonoids; Catechin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Proanthocyanidins; Seeds; Time Factors; Urate Oxidase; Uric Acid; Vitis; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Topics: Animals; Flavonoids; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Plant Leaves; Quercetin; Rutin; Thuja; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
Xanthine oxidase inhibition by 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), an antagonist of adenosine receptors.
Topics: Animals; Blood Pressure; Cardiovascular Diseases; Free Radical Scavengers; Hypertension; Oxidants; Oxidative Stress; Purinergic P1 Receptor Antagonists; Purines; Rats; Superoxides; Uric Acid; Xanthine Oxidase; Xanthines | 2004 |
The danger within.
Topics: Animals; Apoptosis; Cattle; Dendritic Cells; Humans; Hydrogen Peroxide; Mice; Reactive Oxygen Species; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2004 |
Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol.
Topics: Enzyme Inhibitors; Glycosaminoglycans; Kinetics; Oxypurinol; Protein Binding; Superoxides; Uric Acid; Xanthine Oxidase | 2004 |
A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Hyperuricemia; Liver; Male; Mice; Mice, Inbred ICR; Phytotherapy; Plant Bark; Plant Extracts; Plants, Medicinal; Rhizome; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
Increase of uricogenesis in the kuruma shrimp Marsupenaeus japonicus reared under hyper-osmotic conditions.
Topics: Ammonia; Animals; Epidermis; Gills; Hepatopancreas; Hypoxanthine; Osmosis; Penaeidae; Sodium Chloride; Urate Oxidase; Urea; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2004 |
[Xanthinuria with xanthine lithiasis in a patient with Lesch-Nyhan syndrome under allopurinol therapy].
Topics: Allopurinol; Child; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Hypoxanthine; Kidney Calculi; Lesch-Nyhan Syndrome; Male; Uric Acid; Xanthine | 2004 |
Uric acid promotes tumor immune rejection.
Topics: Allopurinol; Animals; Apoptosis; Cell Division; Chickens; Enzyme Inhibitors; Female; Graft Rejection; Immune System; Injections, Subcutaneous; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Ovalbumin; Thymoma; Thymus Neoplasms; Urate Oxidase; Uric Acid | 2004 |
Use of single-dose rasburicase in an obese female.
Topics: Allopurinol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Obesity; Recombinant Proteins; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2004 |
Urinary excretion of purine derivatives as an index of microbial protein synthesis in the camel (Camelus dromedarius).
Topics: Allantoin; Animals; Bacterial Proteins; Camelus; Diet; Duodenum; Fasting; Female; Hypoxanthine; Purines; Rumen; Uric Acid; Xanthine; Xanthine Oxidase | 2004 |
Excretion of uric acid and allantoin by rats depleted of liver xanthine oxidase.
Topics: Allantoin; Animals; Body Fluids; Liver; Rats; Uric Acid; Xanthine Oxidase; Xanthines | 1950 |
Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk.
Topics: Aged; Allopurinol; Biomarkers; Brachial Artery; Cardiovascular Diseases; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hyperuricemia; Male; Middle Aged; Observer Variation; Risk Factors; Statistics as Topic; Uric Acid; Vasodilation; Xanthine Oxidase | 2004 |
[Diagnosis and prevention of uric acid stones].
Topics: Adult; Allopurinol; Female; Fluid Therapy; Humans; Hydrogen-Ion Concentration; Hyperuricemia; Kidney Calculi; Kidney Function Tests; Male; Risk Factors; Tomography, X-Ray Computed; Uric Acid; Uricosuric Agents; Urodynamics | 2004 |
The efficacy of combined low dose of Allopurinol and benzbromarone compared to standard dose of Allopurinol in hyperuricemia.
Topics: Allopurinol; Benzbromarone; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Prospective Studies; Treatment Outcome; Uric Acid; Uricosuric Agents | 2004 |
Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.
Topics: Animals; Blood Urea Nitrogen; Cyclooxygenase 2; Disease Progression; Enzyme Induction; Female; Genes, Lethal; Genetic Heterogeneity; Hypertension; Inflammation; Kidney; Kidney Diseases; Male; Mice; Mice, Knockout; NIH 3T3 Cells; Phenotype; Prostaglandin-Endoperoxide Synthases; Uric Acid; Xanthine Oxidase | 2004 |
Effect of Wen-Pi-Tang extract on lung damage by influenza virus infection.
Topics: Allantoin; Allopurinol; Animals; Body Weight; Catalase; Drugs, Chinese Herbal; Influenza A virus; Lung; Male; Mice; Mice, Inbred ICR; Molecular Structure; Orthomyxoviridae Infections; Oxidative Stress; Superoxide Dismutase; Uric Acid; Xanthine Oxidase | 2004 |
[Effects of processing Phellodendron amurense with salt on anti-gout].
Topics: Animals; Drugs, Chinese Herbal; Gout Suppressants; Hot Temperature; Hyperuricemia; Liver; Male; Mice; Phellodendron; Plants, Medicinal; Random Allocation; Sodium Chloride; Technology, Pharmaceutical; Uric Acid; Xanthine Oxidase | 2005 |
Evaluation and standardisation of the antioxidant properties of two Indian remedies with biochemical test assays.
Topics: Antioxidants; Cell Survival; Extracellular Space; Granulocytes; Humans; Hyaluronic Acid; Hydrogen Peroxide; Hydroxyl Radical; Hydroxylamine; Hypoxanthine; In Vitro Techniques; India; Leukocytes; Medicine, Ayurvedic; Oxidants; Peroxidase; Phenols; Reactive Oxygen Species; Superoxides; Uric Acid; Xanthine Oxidase | 2005 |
My big toe has been extremely painful for some time. I thought it was a bunion, but I've been told I have gout. I thought gout was something only overweight men developed. What is it?
Topics: Allopurinol; Drinking; Gout; Gout Suppressants; Humans; Male; Purines; Toes; Uric Acid | 2005 |
[Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats].
Topics: Animals; Anti-Infective Agents; Brazil; Caffeic Acids; China; Coumaric Acids; Disease Models, Animal; Flavonoids; Gout; Hyperuricemia; Male; Oxonic Acid; Phenylethyl Alcohol; Phenylpropionates; Propionates; Propolis; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2005 |
An increase of uricogenesis in the Kuruma shrimp Marsupenaeus japonicus under nitrite stress.
Topics: Ammonia; Animals; Enzyme Activation; Gills; Hepatopancreas; Hypoxanthine; Nitrites; Penaeidae; Taiwan; Urate Oxidase; Urea; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2005 |
Xanthine oxidase inhibitors: an emerging class of drugs for heart failure.
Topics: Allopurinol; Animals; Enzyme Inhibitors; Heart Failure; Humans; Mechanoreceptors; Nitric Oxide; Uric Acid; Xanthine Oxidase | 2005 |
Eighteen-year follow-up of a patient with partial hypoxanthine phosphoribosyltransferase deficiency and a new mutation.
Topics: Allopurinol; Child, Preschool; Enzyme Inhibitors; Follow-Up Studies; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Male; Point Mutation; Treatment Outcome; Uric Acid; Urinary Calculi | 2005 |
Optimal management of chronic gout: attempting to render the (t)issues crystal-clear.
Topics: Allopurinol; Anti-Inflammatory Agents; Benzbromarone; Chronic Disease; Colchicine; Drug Hypersensitivity; Gout; Humans; Uric Acid; Uricosuric Agents | 2005 |
Urinary excretion of purine derivatives in Bos indicus x Bos taurus crossbred cattle.
Topics: Animals; Cattle; Duodenum; Eating; Fasting; Intestines; Liver; Male; Purines; Uric Acid; Xanthine Oxidase | 2005 |
Effects of allopurinol, a xanthine oxidase inhibitor, on renal injury in hypercholesterolemia-induced hypertensive rats.
Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Cholesterol; Creatinine; Enzyme Inhibitors; Heart Rate; Hemodynamics; Hypercholesterolemia; Hypertension; Iron; Kidney; Kidney Diseases; Kidney Function Tests; Male; Malondialdehyde; Nitric Oxide; Proteinuria; Rats; Rats, Sprague-Dawley; Triglycerides; Uric Acid; Xanthine Oxidase | 2005 |
Protective effects of L-arginine on pulmonary oxidative stress and antioxidant defenses during exhaustive exercise in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Arginine; Catalase; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxidation; Lung; Male; Malondialdehyde; Nitrates; Nitrites; Oxidative Stress; Peroxidase; Physical Conditioning, Animal; Proteins; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Uric Acid; Xanthine Oxidase | 2005 |
Fatal drug reaction due to allopurinol therapy in a 72-year-old man.
Topics: Aged; Allopurinol; Epidermis; Fatal Outcome; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Necrosis; Stevens-Johnson Syndrome; Uric Acid | 2005 |
Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat.
Topics: Acetophenones; Adrenocorticotropic Hormone; Allopurinol; Animals; Antihypertensive Agents; Antioxidants; Aorta, Thoracic; Blood Pressure; Body Weight; Enzyme Inhibitors; Hypertension; Isoprostanes; Male; NADPH Oxidases; Organ Size; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Thymus Gland; Uric Acid; Xanthine Oxidase | 2005 |
[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout].
Topics: Amino Acids; Autoimmune Diseases; Gout; Humans; Hyperuricemia; Lipid Peroxides; Purines; Uric Acid; Xanthine Oxidase | 2005 |
The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity.
Topics: Alkaline Phosphatase; Animals; Antioxidants; Creatinine; Enzyme Inhibitors; Flavonoids; Hyperuricemia; In Vitro Techniques; Kidney; Kinetics; Male; Microvilli; Oxonic Acid; Rats; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2006 |
Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver.
Topics: Administration, Oral; Allopurinol; Animals; Cinnamomum aromaticum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperuricemia; Liver; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Bark; Plant Oils; Time Factors; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2006 |
Lycopene supplementation attenuated xanthine oxidase and myeloperoxidase activities in skeletal muscle tissues of rats after exhaustive exercise.
Topics: Analysis of Variance; Animals; Antioxidants; Carotenoids; Dietary Supplements; Erythrocytes; Glutathione; Lipid Peroxidation; Liver; Lycopene; Male; Models, Animal; Muscle Fatigue; Muscle, Skeletal; Myocardium; Oxidative Stress; Peroxidase; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2005 |
Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats.
Topics: Administration, Oral; Allopurinol; Animals; Chrysanthemum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Esters; Flavones; Hyperuricemia; Inhibitory Concentration 50; Injections, Intraperitoneal; Liver; Male; Oxonic Acid; Quinic Acid; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2005 |
Febuxostat--treatment for hyperuricemia and gout?
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Probenecid; Thiazoles; Uric Acid; Xanthine Oxidase | 2005 |
Allopurinol or oxypurinol in heart failure therapy - a promising new development or end of story?
Topics: Allopurinol; Antioxidants; Enzyme Inhibitors; Heart Failure; Humans; Oxypurinol; Randomized Controlled Trials as Topic; Uric Acid; Xanthine Oxidase | 2005 |
Effect and mechanism of total saponin of Dioscorea on animal experimental hyperuricemia.
Topics: Animals; Dioscorea; Disease Models, Animal; Hyperuricemia; Injections, Intraperitoneal; Liver; Male; Mice; Oxonic Acid; Rats; Rats, Wistar; Saponins; Uric Acid; Xanthine Oxidase; Yeasts | 2006 |
[Gout as an unusual cause of pelvic pain].
Topics: Aged, 80 and over; Allopurinol; Colchicine; Crystallization; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Pelvic Pain; Prednisone; Treatment Outcome; Uric Acid | 2006 |
[Two cases of uric acid stones unsuccessfully dissociated by oral chemolysis].
Topics: Administration, Oral; Allopurinol; Calcium Oxalate; Calcium Phosphates; Citric Acid; Female; Humans; Kidney Calculi; Lithotripsy; Male; Middle Aged; Uric Acid | 2006 |
Biochemical characterization of some pyrazolopyrimidine-based inhibitors of xanthine oxidase.
Topics: Allopurinol; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Uric Acid; Xanthine; Xanthine Oxidase | 2006 |
Antioxidants from Rabdosia japonica.
Topics: Antioxidants; Biphenyl Compounds; Cinnamates; Depsides; Flavones; Flavonoids; Flavonols; Inhibitory Concentration 50; Isodon; Picrates; Plant Extracts; Plant Leaves; Rosmarinic Acid; Superoxides; Uric Acid; Xanthine Oxidase | 2006 |
[Hyperuricemia and gout: diagnosis and therapy].
Topics: Allopurinol; Anti-Inflammatory Agents; Colchicine; Diagnosis, Differential; Gout; Gout Suppressants; Humans; Hyperuricemia; Risk Factors; Uric Acid | 2006 |
Serum urate levels and gout flares: analysis from managed care data.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Allopurinol; Cohort Studies; Databases as Topic; Female; Gout; Gout Suppressants; Humans; Male; Managed Care Programs; Middle Aged; Retrospective Studies; Secondary Prevention; Sex Factors; United States; Uric Acid | 2006 |
Quantification of uric acid, xanthine and hypoxanthine in human serum by HPLC for pharmacodynamic studies.
Topics: Chromatography, High Pressure Liquid; Enzyme Inhibitors; Humans; Hypoxanthine; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Uric Acid; Xanthine; Xanthine Oxidase | 2006 |
Effects of allopurinol on beer-induced increases in plasma concentrations and urinary excretion of purine bases (uric acid, hypoxanthine, and xanthine).
Topics: Adult; Allopurinol; Beer; Ethanol; Humans; Hypoxanthine; Lactic Acid; Male; Oxypurinol; Purines; Uric Acid; Uridine; Xanthine | 2006 |
Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricemia in patients with gout.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Creatinine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Practice Guidelines as Topic; Treatment Outcome; Uric Acid | 2006 |
Gout's not just for the gluttonous.
Topics: Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Risk Factors; Sex Factors; Socioeconomic Factors; Thiazoles; Uric Acid | 2006 |
Uric acid in CHF: marker or player in a metabolic disease?
Topics: Biomarkers; Heart Failure; Humans; Uric Acid; Xanthine Oxidase | 2007 |
Xanthine oxidase inhibitory activity of alkyl gallates.
Topics: Alkylation; Binding Sites; Enzyme Inhibitors; Esters; Free Radical Scavengers; Gallic Acid; Hydrogen Peroxide; Hydrophobic and Hydrophilic Interactions; Oxygen; Structure-Activity Relationship; Superoxides; Uric Acid; Xanthine Oxidase | 2006 |
[Polyarticular gout in young adults: a curable rheumatic disease].
Topics: Adult; Allopurinol; Arthritis; Arthritis, Gouty; Colchicine; Diagnosis, Differential; Humans; Male; Uric Acid | 2006 |
Febuxostat for prevention of gout attacks.
Topics: Allopurinol; Canada; Clinical Trials, Phase III as Topic; Gout; Gout Suppressants; Humans; Hyperuricemia; Randomized Controlled Trials as Topic; Thiazoles; Uric Acid; Xanthine Oxidase | 2006 |
Using serum urate levels to determine the period free of gouty symptoms after withdrawal of long-term urate-lowering therapy: a prospective study.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Arthritis, Gouty; Benzbromarone; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Gout Suppressants; Humans; Life Style; Middle Aged; Predictive Value of Tests; Prospective Studies; Secondary Prevention; Time Factors; Uric Acid | 2006 |
Xanthine oxidase inhibitory activity of some Indian medical plants.
Topics: Animals; Female; Hyperuricemia; India; Lethal Dose 50; Magnoliopsida; Male; Medicine, Traditional; Mice; Oxonic Acid; Plant Extracts; Plant Leaves; Plants, Medicinal; Uric Acid; Xanthine Oxidase | 2007 |
Inhibition of xanthine oxidase improves myocardial contractility in patients with ischemic cardiomyopathy.
Topics: Aged; Cardiomyopathies; Cardiotonic Agents; Enzyme Inhibitors; Female; Humans; Hypoxanthine; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Oxypurinol; Reactive Oxygen Species; Uric Acid; Xanthine; Xanthine Oxidase | 2006 |
Excellent response to the clinical treatment of tophaceous gout.
Topics: Aged; Allopurinol; Benzbromarone; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Treatment Outcome; Uric Acid; Uricosuric Agents | 2007 |
J-shaped mortality relationship for uric acid in CKD.
Topics: Adult; Aged; Allopurinol; Antimetabolites; Cause of Death; Comorbidity; Confounding Factors, Epidemiologic; Diabetic Nephropathies; Diuretics; Female; Follow-Up Studies; Glomerulonephritis; Humans; Hyperuricemia; Male; Middle Aged; Nutritional Status; Phosphates; Polycystic Kidney Diseases; Proportional Hazards Models; Prospective Studies; Renal Insufficiency, Chronic; Renal Replacement Therapy; Survival Analysis; Triglycerides; Uric Acid | 2006 |
Efficacy and safety of allopurinol in patients with the Lesch-Nyhan syndrome and partial hypoxanthine- phosphoribosyltransferase deficiency: a follow-up study of 18 Spanish patients.
Topics: Adolescent; Adult; Allopurinol; Child; Child, Preschool; Follow-Up Studies; Humans; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Infant; Lesch-Nyhan Syndrome; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Spain; Uric Acid; Xanthine | 2006 |
Purine catabolism in advanced carotid artery plaque.
Topics: Aged; Aged, 80 and over; Allantoin; Allopurinol; Carotid Stenosis; Chemistry, Clinical; Female; Free Radicals; Humans; Hypoxanthine; Male; Middle Aged; Oxidants; Oxypurinol; Purines; Uric Acid; Xanthine | 2006 |
Levels and interactions of plasma xanthine oxidase, catalase and liver function parameters in Nigerian children with Plasmodium falciparum infection.
Topics: Adolescent; Alanine Transaminase; Animals; Aspartate Aminotransferase, Mitochondrial; Bilirubin; Catalase; Child; Child, Preschool; Female; Hemoglobins; Humans; Liver; Liver Function Tests; Malaria, Falciparum; Male; Multivariate Analysis; Nigeria; Parasitemia; Plasmodium falciparum; Uric Acid; Xanthine Oxidase | 2006 |
Brain ECF antioxidant interactions in hamsters during arousal from hibernation.
Topics: Analysis of Variance; Animals; Antioxidants; Arousal; Ascorbic Acid; Body Temperature Regulation; Cricetinae; Extracellular Fluid; Female; Free Radicals; Glutathione; Hibernation; Male; Mesocricetus; Microdialysis; Neostriatum; Statistics, Nonparametric; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2007 |
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Reproducibility of Results; Sensitivity and Specificity; Smoking; Theophylline; Uracil; Uric Acid; Xanthine Oxidase; Xanthines | 2007 |
Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats.
Topics: Allopurinol; Animals; Blood Pressure; Carotid Arteries; Cell Proliferation; Cells, Cultured; Heart Rate; Hyperplasia; Hypertension; Ligation; Male; Myocytes, Smooth Muscle; Rats; Rats, Inbred SHR; Tunica Media; Uric Acid; Xanthine; Xanthine Oxidase | 2006 |
Xanthine oxidase-derived reactive oxygen species contribute to the development of D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Allopurinol; Animals; Antioxidants; Ascorbic Acid; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver Injury; Galactosamine; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Neutrophils; Peroxidase; Phospholipid Hydroperoxide Glutathione Peroxidase; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2007 |
Treatment of hyperuricemia in essential hypertension.
Topics: Allopurinol; Animals; Clinical Trials as Topic; Enzyme Inhibitors; Hypertension; Hyperuricemia; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Risk Factors; Urate Oxidase; Uric Acid | 2007 |
Letter by Kielstein et al regarding article, "High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid".
Topics: Allopurinol; Glomerular Filtration Rate; Heart Failure; Humans; Kidney; Kidney Diseases; Oxidative Stress; Oxypurinol; Uric Acid | 2007 |
Concordance of the management of chronic gout in a UK primary-care population with the EULAR gout recommendations.
Topics: Adult; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colchicine; Diuretics; England; Family Practice; Female; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Middle Aged; Practice Guidelines as Topic; Uric Acid; Uricosuric Agents | 2007 |
Preferential inhibition of xanthine oxidase by 2-amino-6-hydroxy-8-mercaptopurine and 2-amino-6-purine thiol.
Topics: Adenine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxylation; Kinetics; Mercaptopurine; Models, Chemical; Molecular Structure; Substrate Specificity; Thioguanine; Uric Acid; Xanthine; Xanthine Oxidase; Xanthines | 2007 |
Quality of care for gout in the US needs improvement.
Topics: Aged; Allopurinol; Blood Cell Count; Colchicine; Comorbidity; Creatine Kinase; Evidence-Based Medicine; Female; Gout; Gout Suppressants; Guideline Adherence; Humans; Male; Minnesota; Practice Guidelines as Topic; Professional Practice; Quality Indicators, Health Care; Quality of Health Care; Renal Insufficiency; Uric Acid; Veterans | 2007 |
Serum uric acid, the endothelium and hypertension: an association revisited.
Topics: Allopurinol; Endothelium, Vascular; Humans; Hypertension; Uric Acid | 2007 |
Serum uric acid is associated with microvascular function in hypertensive individuals.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Brachial Artery; C-Reactive Protein; Cholesterol, HDL; Female; Forearm; Humans; Hypertension; Male; Microcirculation; Middle Aged; Regional Blood Flow; Regression Analysis; Uric Acid | 2007 |
New treatments for gout.
Topics: Allopurinol; Ascorbic Acid; Female; Fenofibrate; Gout; Gout Suppressants; Humans; Losartan; Male; Sensitivity and Specificity; Urate Oxidase; Uric Acid | 2007 |
Morphine enhances purine nucleotide catabolism in vivo and in vitro.
Topics: Adenosine Deaminase; Animals; Blood Urea Nitrogen; Cell Line, Tumor; Female; Morphine; Purine Nucleotides; Rats; Rats, Wistar; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2007 |
Status of uric acid management in hypertensive subjects.
Topics: Aged; Aged, 80 and over; Cardiology; Cross-Sectional Studies; Enzyme Inhibitors; Female; Humans; Hypertension; Hyperuricemia; Institutional Practice; Japan; Male; Practice Patterns, Physicians'; Private Practice; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2007 |
Effects of tocopherols and 2,2'-carboxyethyl hydroxychromans on phorbol-ester-stimulated neutrophils.
Topics: Antioxidants; Carcinogens; Cells, Cultured; Chromans; Cytochromes c; Dose-Response Relationship, Drug; Humans; NADPH Oxidases; Neutrophils; Oxidative Stress; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate; Time Factors; Tocopherols; Uric Acid; Xanthine Oxidase | 2008 |
Is uric acid itself a player or a bystander in the pathophysiology of chronic heart failure?
Topics: Chronic Disease; Endothelium, Vascular; Heart Failure; Humans; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2008 |
Efficacy and safety of allopurinol in patients with hypoxanthine-guanine phosphoribosyltransferase deficiency.
Topics: Adolescent; Adult; Allopurinol; Antimetabolites; Child; Child, Preschool; Dose-Response Relationship, Drug; Follow-Up Studies; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Kidney; Lesch-Nyhan Syndrome; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Retrospective Studies; Treatment Outcome; Uric Acid | 2007 |
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase.
Topics: Allopurinol; Crystallography, X-Ray; Enzyme Inhibitors; Hydrogen Bonding; Models, Molecular; Organometallic Compounds; Schiff Bases; Transition Elements; Uric Acid; Xanthine Oxidase | 2008 |
Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
Topics: Allopurinol; Animals; Blood Pressure; Body Weight; Diuretics; Fructose; Gout Suppressants; Hydrochlorothiazide; Hyperglycemia; Hypertension; Hypertriglyceridemia; Hyperuricemia; Hypokalemia; Insulin; Insulin Resistance; Kidney; Male; Metabolic Syndrome; Nitric Oxide; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Uric Acid | 2007 |
Posttranslational ruling of xanthine oxidase activity in bovine milk by its substrates.
Topics: Animals; Bacterial Infections; Cattle; Escherichia coli; Female; Hydrogen Peroxide; Hypoxanthine; Mammary Glands, Animal; Milk; Oxytocics; Oxytocin; Protein Processing, Post-Translational; Staphylococcus aureus; Substrate Specificity; Time Factors; Uric Acid; Xanthine; Xanthine Oxidase | 2007 |
[European League Against Rheumatism evidence-based recommendations for diagnosis and management of gout].
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Colchicine; Delphi Technique; Europe; Evidence-Based Medicine; Genetic Predisposition to Disease; Gout; Gout Suppressants; Humans; Life Style; Societies, Medical; Uric Acid | 2007 |
Partial hypoxanthine-guanine phosphoribosyltransferase deficiency due to a newly recognized mutation presenting with renal failure in a one-year-old boy.
Topics: Allopurinol; Antimetabolites; Creatinine; Electrophoresis, Agar Gel; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Lesch-Nyhan Syndrome; Male; Metabolic Clearance Rate; Mutation, Missense; Polymorphism, Restriction Fragment Length; Renal Insufficiency; Uric Acid | 2008 |
Rasburicase for tophaceous gout not treatable with allopurinol: an exploratory study.
Topics: Aged; Aged, 80 and over; Allopurinol; Contraindications; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Urate Oxidase; Uric Acid | 2007 |
Purine catabolic enzymes and nitric oxide in patients with recurrent aphthous ulceration.
Topics: Adenosine Deaminase; Adult; Case-Control Studies; Female; Humans; Male; Malondialdehyde; Nitric Oxide; Purines; Stomatitis, Aphthous; Uric Acid; Xanthine Oxidase | 2007 |
Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000-2005.
Topics: Aged; Allopurinol; Drug Administration Schedule; Drug Monitoring; Epidemiologic Methods; Family Practice; Female; Germany; Gout; Gout Suppressants; Humans; Male; Middle Aged; Recurrence; United Kingdom; Uric Acid | 2008 |
Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection.
Topics: Aged; Antioxidants; Female; Hepatectomy; Humans; Intraoperative Period; Liver; Liver Neoplasms; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; Splanchnic Circulation; Uric Acid; Xanthine Oxidase | 2008 |
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia.
Topics: Animals; Blood Pressure; Febuxostat; Follow-Up Studies; Gout Suppressants; Hypertension, Renal; Hyperuricemia; Kidney Glomerulus; Male; Oxonic Acid; Rats; Rats, Sprague-Dawley; Renal Circulation; Thiazoles; Uric Acid; Xanthine Oxidase | 2008 |
Tumor lysis syndrome: current perspective.
Topics: Allopurinol; Area Under Curve; Hematologic Neoplasms; Humans; Medical Oncology; Models, Biological; Risk Factors; Treatment Outcome; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2008 |
Xanthine oxidase inhibitors the unappreciated treatment for heart failure.
Topics: Allopurinol; Animals; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Female; Heart Failure; Humans; Male; Uric Acid; Xanthine Oxidase | 2007 |
Effects of allopurinol on plasma uric acid levels in normouricaemic and hyperuricaemic green iguanas (Iguana iguana).
Topics: Administration, Oral; Allopurinol; Animals; Antimetabolites; Blood Proteins; Body Weight; Cross-Over Studies; Diet; Dietary Proteins; Hematocrit; Hyperuricemia; Iguanas; Kidney; Liver; Male; Random Allocation; Uric Acid | 2008 |
Gout: joint pain and more.
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Gout; Gout Suppressants; Humans; Male; Probenecid; Uric Acid; Uricosuric Agents | 2007 |
Hypouricemic effects of phenylpropanoid glycosides acteoside of Scrophularia ningpoensis on serum uric acid levels in potassium oxonate-pretreated Mice.
Topics: Animals; Glycosides; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Plant Roots; Scrophularia; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2008 |
Presence of epidermal allantoin further supports oxidative stress in vitiligo.
Topics: Allantoin; Blotting, Western; Case-Control Studies; Catalytic Domain; Cells, Cultured; Computer Simulation; Epidermis; Flavin-Adenine Dinucleotide; Humans; Hydrogen Peroxide; Immunohistochemistry; Keratinocytes; Melanocytes; Models, Chemical; Molecular Structure; Oxidation-Reduction; Oxidative Stress; RNA, Messenger; Uric Acid; Vitiligo; Xanthine Dehydrogenase; Xanthine Oxidase | 2008 |
EPR studies on the superoxide-scavenging capacity of the nutraceutical resveratrol.
Topics: Dietary Supplements; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Oxygen Consumption; Pyrroles; Resveratrol; Spin Labels; Stilbenes; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase | 2008 |
Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Creatinine; Desoxycorticosterone; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Free Radical Scavengers; Hypertension; Lipid Peroxidation; Male; Mesenteric Arteries; Mitochondria; NADPH Oxidases; Nephrectomy; Oxidative Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Superoxides; Thiobarbituric Acid Reactive Substances; Uncoupling Agents; Uric Acid; Vascular Resistance; Xanthine Oxidase | 2008 |
An initial presentation of polyarticular gout with spinal involvement.
Topics: Aged, 80 and over; Allopurinol; Anti-Inflammatory Agents; Diffusion Magnetic Resonance Imaging; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Low Back Pain; Lumbar Vertebrae; Prednisone; Uric Acid | 2008 |
The ongoing search for a stratified medicine approach in heart failure.
Topics: Enzyme Inhibitors; Heart Failure; Humans; Natriuretic Peptide, Brain; Oxypurinol; Risk Factors; Systole; Uric Acid; Xanthine Oxidase | 2008 |
Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease.
Topics: Adult; Biological Availability; Case-Control Studies; Crohn Disease; Female; Humans; Immunosuppressive Agents; Intestine, Small; Mercaptopurine; Methyltransferases; Uric Acid; Xanthine Oxidase | 2008 |
Xanthine oxidase-dependent ROS production mediates vitamin A pro-oxidant effects in cultured Sertoli cells.
Topics: Allopurinol; Animals; Male; Models, Biological; NAD; Oxidants; Rats; Reactive Oxygen Species; Sertoli Cells; Testis; Time Factors; Uric Acid; Vitamin A; Xanthine Oxidase | 2008 |
Renierol from marine sponge Haliclona.SP.: a natural inhibitor of xanthine oxidase with hypouricemic effects.
Topics: Animals; Enzyme Inhibitors; Isoquinolines; Mice; Plant Extracts; Porifera; Quinones; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase | 2008 |
Hyperuricosuria, an often overlooked cause of recurrent oliguria in children.
Topics: Alkyl and Aryl Transferases; Allopurinol; Child, Preschool; Female; Humans; Oliguria; Treatment Outcome; Uric Acid; Urologic Diseases | 2008 |
Studies on diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in rats.
Topics: Allopurinol; Animals; Chromatography, Thin Layer; Diuretics; Hydrogen-Ion Concentration; Male; Orthosiphon; Plant Extracts; Rats; Rats, Sprague-Dawley; Sodium; Uric Acid | 2008 |
Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells.
Topics: Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Gene Expression Regulation, Enzymologic; Glutathione; HeLa Cells; Humans; Inflammation; Kinetics; Lung; Models, Biological; NADPH Oxidases; Picornaviridae Infections; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2008 |
Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice.
Topics: Acrolein; Administration, Oral; Allopurinol; Animals; Cinnamomum; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Inhibitory Concentration 50; Male; Mice; Mice, Inbred ICR; Oils, Volatile; Oxonic Acid; Plant Extracts; Plant Leaves; Plant Oils; Taiwan; Uric Acid; Xanthine Oxidase | 2008 |
Lithospermic acid as a novel xanthine oxidase inhibitor has anti-inflammatory and hypouricemic effects in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Benzofurans; Depsides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hyperuricemia; Inflammation; Male; Molecular Conformation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxonic Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Uric Acid; Xanthine Oxidase | 2008 |
Opportunities for improving medication use and monitoring in gout.
Topics: Aged; Allopurinol; Biomarkers; Colchicine; Drug Administration Schedule; Drug Monitoring; Female; Gout; Gout Suppressants; Guideline Adherence; Humans; Male; Middle Aged; Practice Guidelines as Topic; Probenecid; Quality of Health Care; Renal Insufficiency; Treatment Outcome; Uric Acid | 2009 |
Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor.
Topics: Allopurinol; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomyopathies; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Imidazoles; Male; Myocardium; NG-Nitroarginine Methyl Ester; Olmesartan Medoxomil; Rats; Rats, Wistar; Tetrazoles; Time Factors; Uric Acid; Ventricular Remodeling; Xanthine Oxidase | 2008 |
Effect of hypouricaemic and hyperuricaemic drugs on the renal urate efflux transporter, multidrug resistance protein 4.
Topics: Allopurinol; Biological Transport; Cell Line; Diuretics; Dose-Response Relationship, Drug; Drug Delivery Systems; Homeostasis; Humans; Multidrug Resistance-Associated Proteins; Oxypurinol; Salicylates; Uric Acid; Uricosuric Agents | 2008 |
Role of the nitro functionality in the DNA binding of 3-nitro-10-methylbenzothiazolo[3,2-a]quinolinium chloride.
Topics: Animals; Binding Sites; Cattle; Cell Survival; Chromatography, Liquid; DNA; DNA Adducts; Drug Screening Assays, Antitumor; Humans; Hypoxanthine; Molecular Structure; Oxidation-Reduction; Quinolinium Compounds; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured; Uric Acid; Xanthine Oxidase | 2008 |
Effects of angiotensin II receptor blockers on renal handling of uric acid in rats.
Topics: Absorption; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Biphenyl Compounds; Imidazoles; Kidney; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley; Telmisartan; Tetrazoles; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2008 |
Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats.
Topics: Animals; Hyperuricemia; Liver; Male; Onions; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2008 |
Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction.
Topics: Animals; Diaphragm; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Hypoxanthine; Lipid Peroxidation; Muscle Contraction; Muscle Weakness; Muscular Atrophy; Oxidative Stress; Oxypurinol; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Time Factors; Uric Acid; Ventilator-Induced Lung Injury; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2009 |
Gout management: let's get it right this time.
Topics: Administration, Oral; Allopurinol; Dose-Response Relationship, Drug; Drug Evaluation; Europe; Febuxostat; Gout; Gout Suppressants; Humans; Thiazoles; Uric Acid; Xanthine Oxidase | 2008 |
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensins; Animals; Cells, Cultured; Disease Models, Animal; Endothelin-1; Endothelium, Vascular; Hypertension; Hyperuricemia; KATP Channels; Kidney; Kidney Diseases; Male; Nitric Oxide; Oxonic Acid; Propylamines; Rats; Rats, Sprague-Dawley; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2008 |
Uric acid, xanthine oxidase and heart failure: unresolved issues.
Topics: Endothelium, Vascular; Heart Failure; Humans; Risk Assessment; Superoxide Dismutase; Uric Acid; Vasodilation; Xanthine Oxidase | 2008 |
Uric acid deposits in symbiotic marine algae.
Topics: Allopurinol; Animals; Eukaryota; Microscopy, Electron, Transmission; Sea Anemones; Symbiosis; Uric Acid | 2009 |
Phenotyping of N-acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected?
Topics: Acetylation; Adult; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Humans; Male; Phenotype; Time Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines | 2009 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Allopurinol and the role of uric acid in hypertension.
Topics: Adolescent; Allopurinol; Drug Eruptions; Enzyme Inhibitors; Humans; Hypertension; Stevens-Johnson Syndrome; Uric Acid; Xanthine Oxidase | 2009 |
A 31-year-old Army specialist presenting with acute oligoarthritis.
Topics: Acute Disease; Adult; Allopurinol; Arthritis, Gouty; Gout Suppressants; Humans; Male; Military Medicine; Military Personnel; Synovial Fluid; United States; Uric Acid | 2008 |
Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice.
Topics: Animals; Flavonoids; Hyperuricemia; Lonicera; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; Molecular Structure; Plant Extracts; Uric Acid; Xanthine Oxidase | 2009 |
Effect of exercise training on ethanol-induced oxidative damage in aged rats.
Topics: Aging; Alcohol Drinking; Animals; Antioxidants; Ascorbic Acid; Central Nervous System Depressants; Ethanol; Glutathione; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxidative Stress; Physical Conditioning, Animal; Physical Endurance; Rats; Rats, Wistar; Uric Acid; Xanthine Oxidase | 2009 |
Uric acid and cardiovascular risk.
Topics: Biomarkers; Cardiovascular Diseases; Humans; Hyperuricemia; Purines; Risk Factors; Uric Acid; Xanthine Oxidase | 2009 |
Uric acid and cardiovascular risk.
Topics: Allopurinol; Antimetabolites; Biomarkers; Cardiovascular Diseases; Humans; Hyperuricemia; Kidney Diseases; Risk Factors; Uric Acid | 2009 |
Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study.
Topics: Aged; Aged, 80 and over; Biomarkers; Female; Heart Failure; Humans; Hyperuricemia; Incidence; Kaplan-Meier Estimate; Male; Propensity Score; Renal Insufficiency; Uric Acid; Xanthine Oxidase | 2010 |
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.
Topics: Allopurinol; Animals; Biomarkers; Bleomycin; Bronchoalveolar Lavage Fluid; Carrier Proteins; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Interleukin-1beta; Lung; Lung Injury; Mice; Myeloid Differentiation Factor 88; NLR Family, Pyrin Domain-Containing 3 Protein; Pneumonia; Pulmonary Fibrosis; Uric Acid | 2009 |
Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (CUPRAC) method.
Topics: Antioxidants; Copper; Flavonols; Free Radical Scavengers; Hydrogen Peroxide; Phenols; Reactive Oxygen Species; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2009 |
Clinical efficacy and safety of successful longterm urate lowering with febuxostat or allopurinol in subjects with gout.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Hyperuricemia; Thiazoles; Treatment Outcome; Uric Acid | 2009 |
New gout treatment approved.
Topics: Administration, Oral; Drug Approval; Drug Interactions; Febuxostat; Gout; Gout Suppressants; Humans; Thiazoles; United States; United States Food and Drug Administration; Uric Acid; Xanthine Oxidase | 2009 |
Adherence with urate-lowering therapies for the treatment of gout.
Topics: Age Factors; Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Middle Aged; Probenecid; Sulfinpyrazone; Uric Acid | 2009 |
Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response.
Topics: Allopurinol; Animals; Erythrocytes; Humans; Inflammation; Inflammation Mediators; Plasmodium falciparum; Uric Acid | 2009 |
Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents.
Topics: Animals; Disease Models, Animal; Drug Synergism; Gout Suppressants; Hyperuricemia; Inhibitory Concentration 50; Lignans; Male; Molecular Structure; Phyllanthus; Phytotherapy; Plant Extracts; Plant Leaves; Pyrazinamide; Rats; Rats, Sprague-Dawley; Uric Acid; Urine; Xanthine Oxidase | 2009 |
Simultaneous electrochemical monitoring of metabolites related to the xanthine oxidase pathway using a grinded carbon electrode.
Topics: Allopurinol; Biosensing Techniques; Carbon; Electrochemical Techniques; Electrodes; Enzyme Inhibitors; Humans; Hypoxanthine; Oxypurinol; Purinones; Sensitivity and Specificity; Uric Acid; Xanthine; Xanthine Oxidase | 2009 |
Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice.
Topics: Albuminuria; Allopurinol; Animals; Blood Pressure; Blood Urea Nitrogen; Cell Line; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Enzyme Inhibitors; Hyperuricemia; Intercellular Adhesion Molecule-1; Kidney; Male; Mice; Mice, Inbred C57BL; Nephritis; Oxidative Stress; Time Factors; Uric Acid; Xanthine Oxidase | 2009 |
Impact of noncompliance with urate-lowering drug on serum urate and gout-related healthcare costs: administrative claims analysis.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Drug Therapy, Combination; Female; Gout; Health Care Costs; Humans; Insurance Claim Review; Male; Middle Aged; Patient Compliance; Uric Acid; Uricosuric Agents; Young Adult | 2009 |
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase.
Topics: Biomarkers; Cell Hypoxia; Cell Line; Cell Survival; Glucose; Glutathione; Glutathione Disulfide; Humans; Hyperglycemia; Inflammation Mediators; Interleukin-6; Ischemia; Keratinocytes; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Reperfusion Injury; Superoxides; Uric Acid; Xanthine Oxidase | 2009 |
Ultrasonography shows disappearance of monosodium urate crystal deposition on hyaline cartilage after sustained normouricemia is achieved.
Topics: Aged; Aged, 80 and over; Allopurinol; Cartilage, Articular; Colchicine; Crystallization; Female; Gout; Gout Suppressants; Humans; Hyaline Cartilage; Joints; Male; Middle Aged; Probenecid; Treatment Outcome; Ultrasonography; Uric Acid | 2010 |
Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement.
Topics: Allopurinol; Animals; Antioxidants; Dietary Carbohydrates; Dinoprostone; Fructose; Hyperuricemia; Kidney; Male; Metabolic Syndrome; Nitric Oxide; Organic Anion Transporters; Organic Cation Transport Proteins; Quercetin; Rats; Rats, Sprague-Dawley; Rutin; Uric Acid; Uricosuric Agents | 2009 |
Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens.
Topics: Age Factors; Allantoin; Allopurinol; Animals; Blood Glucose; Body Weight; Chickens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hypoxanthine; Intestines; Liver; Male; Oxidative Stress; Pancreas; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2010 |
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.
Topics: Allopurinol; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Chemokine CCL2; Chemokine CXCL1; Cytoskeletal Proteins; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Hemeproteins; Inflammation; Interferon-gamma; Interleukin-1alpha; Interleukin-1beta; Interleukin-6; Interleukin-8; Macrophages; Malaria, Falciparum; Mice; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Plasmodium falciparum; Signal Transduction; Toll-Like Receptors; Tumor Necrosis Factor-alpha; Uric Acid | 2009 |
The effects of lowering uric acid levels using allopurinol on markers of metabolic syndrome in end-stage renal disease patients: a pilot study.
Topics: Adult; Allopurinol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Metabolic Syndrome; Middle Aged; Pilot Projects; Renal Dialysis; Triglycerides; Uric Acid | 2009 |
Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia.
Topics: Allopurinol; Child; Child, Preschool; Female; Humans; Hyperuricemia; Infant; Male; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Urate Oxidase; Uric Acid | 2010 |
Clinical images: Aggressive gouty arthritis with concurrent involvement of the ankle and cervical spine.
Topics: Administration, Oral; Allopurinol; Ankle; Arthritis, Gouty; Cervical Vertebrae; Drug Therapy, Combination; Glucocorticoids; Gout Suppressants; Humans; Male; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome; Uric Acid | 2009 |
Influence on energy kinetics and histology of different preservation solutions seen during cold ischemia in the liver.
Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Allopurinol; Animals; Energy Metabolism; Glutathione; Hypoxanthine; Insulin; Ischemia; Kinetics; Liver; Male; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Wistar; Reperfusion Injury; Reticulin; Uric Acid; Uridine; Xanthine | 2009 |
Protective effects of L-arginine supplementation against exhaustive exercise-induced oxidative stress in young rat tissues.
Topics: Animals; Arginine; Creatine Kinase; Dietary Supplements; DNA, Mitochondrial; Fatigue; Kidney; Lactates; Lipid Peroxides; Liver; Male; Malondialdehyde; Models, Animal; Muscle, Skeletal; Oxidative Stress; Peroxidase; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2009 |
Xanthine dehydrogenase deficiency with novel sequence variations presenting as rheumatoid arthritis in a 78-year-old patient.
Topics: Aged; Allopurinol; Arthritis, Rheumatoid; Biomarkers; Chromatography, High Pressure Liquid; DNA Mutational Analysis; Exons; Female; Genetic Predisposition to Disease; Genetic Testing; Heterozygote; Humans; Metabolism, Inborn Errors; Mutation, Missense; Nephrocalcinosis; Phenotype; Predictive Value of Tests; Sequence Deletion; Uric Acid; Xanthine Dehydrogenase | 2010 |
Clinical study on treatment of hyperuricaemia by retention enema of Chinese herbal medicine combined with allopurinol.
Topics: Adult; Aged; Allopurinol; Blood Urea Nitrogen; Drugs, Chinese Herbal; Enema; Female; Humans; Hyperuricemia; Lipids; Male; Middle Aged; Uric Acid | 2009 |
[Fever and back pain--a case report of spinal gout].
Topics: Aged; Allopurinol; Arthritis, Gouty; Arthroscopy; Back Pain; Colchicine; Diagnosis, Differential; Drug Therapy, Combination; Fever of Unknown Origin; Follow-Up Studies; Glucocorticoids; Gout Suppressants; Humans; Knee; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Postoperative Complications; Prednisolone; Spondylarthritis; Tomography, X-Ray Computed; Ultrasonography; Uric Acid | 2010 |
The dynamics of chronic gout treatment: medication gaps and return to therapy.
Topics: Age Factors; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Chronic Disease; Cohort Studies; Colchicine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Glucocorticoids; Gout; Gout Suppressants; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Patient Compliance; Probability; Proportional Hazards Models; Risk Assessment; Severity of Illness Index; Sex Factors; Time Factors; Treatment Outcome; Uric Acid | 2010 |
Gouty tophi caused limited knee range of motion: a case report.
Topics: Adult; Allopurinol; Arthritis, Gouty; Arthroscopy; Diagnosis, Differential; Gout Suppressants; Humans; Knee Injuries; Knee Joint; Magnetic Resonance Imaging; Male; Naproxen; Radiography; Range of Motion, Articular; Synovial Membrane; Treatment Outcome; Uric Acid | 2009 |
Serum uric acid levels and renal damage in hyperuricemic hypertensive patients treated with renin-angiotensin system blockers.
Topics: Adult; Aged; Allopurinol; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cross-Sectional Studies; Female; Humans; Hypertension; Hyperuricemia; Kidney; Male; Middle Aged; Regression Analysis; Renin-Angiotensin System; Uric Acid | 2010 |
Uric acid does not affect the acetylcholine-induced relaxation of aorta from normotensive and deoxycorticosterone acetate-salt hypertensive rats.
Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Blotting, Western; Desoxycorticosterone; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Sodium Chloride; Urate Oxidase; Uric Acid; Vasodilator Agents; Xanthine Oxidase | 2010 |
Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice.
Topics: Allopurinol; Animals; Biological Transport; Gout; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred Strains; Organic Anion Transporters; Oxonic Acid; Reverse Transcriptase Polymerase Chain Reaction; Uric Acid | 2010 |
A survey on the management of gout in Malaysia.
Topics: Acute Disease; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colchicine; Cross-Sectional Studies; Cyclooxygenase 2 Inhibitors; Glucocorticoids; Gout; Gout Suppressants; Humans; Malaysia; Primary Health Care; Professional Practice; Reference Values; Surveys and Questionnaires; Uric Acid | 2009 |
Treatment failure gout: failure to treat?
Topics: Allopurinol; Drug Hypersensitivity; General Practice; Gout; Gout Suppressants; Guideline Adherence; Humans; Practice Patterns, Physicians'; Risk Factors; Time Factors; Treatment Failure; Uric Acid | 2010 |
On call. I've had gout for many years. I used to take Zyloprim without any problems, but I just had a severe allergic reaction, so my doctor switched me to Benemid. I'm doing okay, but the drug sometimes upsets my stomach. Do you have any suggestions?
Topics: Allopurinol; Drug Hypersensitivity; Gastritis; Gout; Gout Suppressants; Humans; Male; Middle Aged; Probenecid; Uric Acid; Uricosuric Agents | 2010 |
Risk factors associated with renal lithiasis during uricosuric treatment of hyperuricemia in patients with gout.
Topics: Allopurinol; Benzbromarone; Cohort Studies; Creatinine; Follow-Up Studies; Gout; Humans; Hyperuricemia; Middle Aged; Proportional Hazards Models; Prospective Studies; Renal Colic; Risk Factors; Time Factors; Uric Acid; Uricosuric Agents; Urolithiasis | 2010 |
The beneficial effects of allopurinol in cardiology practice: decrease in uric acid and vascular oxidative stress/ the effects of lowering uric acid levels using allopurinol on markers of metabolic syndrome in end-stage renal disease patients: a pilot stu
Topics: Allopurinol; Free Radical Scavengers; Humans; Kidney Failure, Chronic; Metabolic Syndrome; Oxidative Stress; Pilot Projects; Uric Acid | 2010 |
Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid.
Topics: Animals; Biocatalysis; Catalytic Domain; Cattle; Crystallography, X-Ray; Hydroxylation; Hypoxanthine; Kinetics; Mercaptopurine; Models, Molecular; Oxidation-Reduction; Substrate Specificity; Uric Acid; Xanthine Oxidase | 2010 |
Serum oxidant and antioxidant status during early and late recovery periods following an all-out 21-km run in trained adolescent runners.
Topics: Adolescent; Antioxidants; Athletes; Catalase; Glutathione; Humans; Male; Oxidants; Oxidative Stress; Running; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Uric Acid; Xanthine Oxidase | 2010 |
Lesch-Nyhan syndrome: a novel complex mutation with severe phenotype.
Topics: Allopurinol; Antimetabolites; Fatal Outcome; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Lesch-Nyhan Syndrome; Male; Mutation; Phenotype; Uric Acid | 2010 |
Panniculitis: another clinical expression of gout.
Topics: Adult; Allopurinol; Colchicine; Crystallization; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Microscopy, Polarization; Middle Aged; Panniculitis; Retrospective Studies; Synovial Fluid; Uric Acid | 2011 |
Phytochemicals from Acacia confusa heartwood extracts reduce serum uric acid levels in oxonate-induced mice: their potential use as xanthine oxidase inhibitors.
Topics: Acacia; Animals; Drug Discovery; Enzyme Inhibitors; Flavonoids; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Urate Oxidase; Uric Acid; Wood; Xanthine Oxidase | 2010 |
Clinical evidence of the association between serum perioperative changes in xanthine metabolizing enzymes activity and early post-transplant kidney allograft function.
Topics: Area Under Curve; Biomarkers; Delayed Graft Function; Female; Graft Survival; Humans; Kidney Transplantation; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Perioperative Period; Postoperative Period; Reperfusion Injury; Retrospective Studies; Transplantation, Homologous; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2010 |
The current state of care in gout: Addressing the need for better understanding of an ancient disease.
Topics: Acute Disease; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Arthritis, Rheumatoid; Chronic Disease; Colchicine; Comorbidity; Disease Progression; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Patient Education as Topic; Quality of Life; Risk Factors; Thiazoles; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2010 |
Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats.
Topics: Allopurinol; Animals; Aorta; Arginine; Benzbromarone; Biological Transport; Blood Pressure; Cationic Amino Acid Transporter 1; Disease Models, Animal; Hyperuricemia; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Oxonic Acid; Phosphorylation; Protein Kinase C-alpha; Rats; Rats, Wistar; Tyrosine; Uric Acid; Uricosuric Agents | 2011 |
Olea europaea leaf (Ph.Eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase.
Topics: Allopurinol; Animals; Apigenin; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gout; Iridoid Glucosides; Iridoids; Medicine, Traditional; Olea; Phenols; Plant Extracts; Plant Leaves; Plants, Medicinal; Pyrans; Uric Acid; Xanthine Oxidase | 2011 |
3,5,2',4'-Tetrahydroxychalcone, a new non-purine xanthine oxidase inhibitor.
Topics: Animals; Chalcone; Chalcones; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydroxylation; Hyperuricemia; Kinetics; Mice; Uric Acid; Xanthine Oxidase | 2011 |
Lack of effect of hydrochlorothiazide and low-dose aspirin on the renal clearance of urate and oxypurinol after a single dose of allopurinol in normal volunteers.
Topics: Adolescent; Adult; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromatography, High Pressure Liquid; Diuretics; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hydrochlorothiazide; Kidney; Kidney Function Tests; Male; Middle Aged; Oxypurinol; Uric Acid; Young Adult | 2011 |
Treatment of gout.
Topics: Aged; Allopurinol; Australia; Colchicine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Febuxostat; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Patient Compliance; Practice Guidelines as Topic; Prednisolone; Renal Dialysis; Thiazoles; Uric Acid | 2011 |
Xanthine dehydrogenase electrocatalysis: autocatalysis and novel activity.
Topics: Allopurinol; Biocatalysis; Electrochemistry; Electrodes; Flavin-Adenine Dinucleotide; Hydrogen-Ion Concentration; Hypoxanthine; Imines; NAD; Oxidation-Reduction; Rhodobacter capsulatus; Uric Acid; Xanthine; Xanthine Dehydrogenase | 2011 |
Impact of allopurinol use on urate concentration and cardiovascular outcome.
Topics: Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Cohort Studies; Female; Gout; Gout Suppressants; Hospitalization; Humans; Hyperuricemia; Male; Proportional Hazards Models; Risk Factors; Time Factors; Treatment Outcome; United Kingdom; Uric Acid | 2011 |
MarR homologs with urate-binding signature.
Topics: Amino Acid Sequence; Base Sequence; Deinococcus; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Models, Molecular; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic; Protein Binding; Protein Conformation; Regulon; Repressor Proteins; Sequence Alignment; Uric Acid; Xanthine Oxidase | 2011 |
Hypouricemic effects of anthocyanin extracts of purple sweet potato on potassium oxonate-induced hyperuricemia in mice.
Topics: Allopurinol; Animals; Anthocyanins; Disease Models, Animal; Hyperuricemia; Ipomoea batatas; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Uric Acid | 2011 |
Synthesis, activity testing and molybdenum(VI) complexation of Schiff bases derived from 2,4,6-trihydroxybenzaldehyde investigated as xanthine oxidase inhibitors.
Topics: Benzaldehydes; Enzyme Inhibitors; Molybdenum; Organometallic Compounds; Schiff Bases; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2011 |
Gout.
Topics: Allopurinol; Antihypertensive Agents; Gout; Gout Suppressants; Humans; Hydrochlorothiazide; Hypertension; Uric Acid | 2011 |
Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice.
Topics: Animals; Apigenin; Flavonoids; Flavonols; Genistein; Hyperuricemia; Mice; Quercetin; Rutin; Uric Acid; Xanthine Oxidase | 2011 |
Uric acid and HMGB1 are involved in the induction of autoantibodies elicited in mice infected with mouse hepatitis virus A59.
Topics: Allopurinol; Animals; Autoantibodies; Autoimmunity; Coronavirus Infections; Female; Hepatitis, Viral, Animal; HMGB1 Protein; Hydrolases; Liver; Mice; Mice, Inbred BALB C; Murine hepatitis virus; NF-kappaB-Inducing Kinase; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyruvates; Signal Transduction; Uric Acid | 2011 |
Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Death; Cell Line, Tumor; Cytotoxicity, Immunologic; Deoxycytidine; DNA Damage; Female; Gallbladder Neoplasms; Gemcitabine; Gene Expression; Histocompatibility Antigens Class I; Humans; Kaplan-Meier Estimate; Killer Cells, Natural; Liver Neoplasms; Male; Middle Aged; Pancreatic Neoplasms; Peritoneal Neoplasms; Uric Acid; Xanthine Dehydrogenase | 2011 |
Astilbin attenuates hyperuricemia and ameliorates nephropathy in fructose-induced hyperuricemic rats.
Topics: Animals; Blood Urea Nitrogen; Connective Tissue Growth Factor; Creatinine; Dinoprostone; Disease Models, Animal; Drugs, Chinese Herbal; Flavonols; Fructose; Hyperuricemia; Interleukin-1; Kidney; Kidney Diseases; Male; Phytotherapy; Rats; Rats, Sprague-Dawley; Rhizome; Smilax; Transforming Growth Factor beta1; Uric Acid; Xanthine Oxidase | 2011 |
Febuxostat efficacy in allopurinol-resistant tophaceous gout.
Topics: Allopurinol; Dose-Response Relationship, Drug; Drug Resistance; Febuxostat; Female; Gout; Gout Suppressants; Humans; Thiazoles; Treatment Failure; Treatment Outcome; Uric Acid; Young Adult | 2011 |
Impact of elevated uric acid on ventricular remodeling in infarcted rats with experimental hyperuricemia.
Topics: Allopurinol; Analysis of Variance; Animals; Antioxidants; Atrasentan; Biomarkers; Cyclic N-Oxides; Dinoprost; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Fibrosis; Gout Suppressants; Hypertrophy, Left Ventricular; Hyperuricemia; Isoprostanes; Male; Myocardial Infarction; Myocardium; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin A; RNA, Messenger; Spin Labels; Superoxides; Time Factors; Up-Regulation; Uric Acid; Ventricular Dysfunction, Left; Ventricular Function, Left; Ventricular Remodeling; Xanthine Oxidase | 2011 |
Antioxidant, diuretic activities and polyphenol content of Stereospermum kunthianum Cham. (Bignoniaceae).
Topics: Acetone; Animals; Antioxidants; Bignoniaceae; Biphenyl Compounds; Chromatography, High Pressure Liquid; Diuretics; Flavonoids; Inhibitory Concentration 50; Male; Mass Spectrometry; Methanol; Picrates; Plant Extracts; Polyphenols; Potassium; Rats; Rats, Wistar; Sodium; Spectrophotometry; Uric Acid; Water; Xanthine Oxidase | 2011 |
Safety and efficacy of febuxostat treatment in subjects with gout and severe allopurinol adverse reactions.
Topics: Aged; Aged, 80 and over; Allopurinol; Drug Monitoring; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Retrospective Studies; Severity of Illness Index; Thiazoles; Uric Acid | 2011 |
Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Arthritis, Gouty; Chronic Disease; Creatinine; Dose-Response Relationship, Drug; Drug Monitoring; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Kidney Function Tests; Male; Middle Aged; Oxypurinol; Standard of Care; Uric Acid | 2011 |
Chronic kidney disease in gout in a managed care setting.
Topics: Adult; Aged; Allopurinol; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Managed Care Programs; Middle Aged; Retrospective Studies; Uric Acid | 2011 |
Improving the use of allopurinol in chronic gout: monitoring oxypurinol levels to guide therapy.
Topics: Allopurinol; Arthritis, Gouty; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Male; Oxypurinol; Uric Acid | 2011 |
Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Carrier Proteins; Creatinine; Disease Models, Animal; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Hyperuricemia; Kidney; Male; Membrane Proteins; Mice; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Quercetin; RNA, Messenger; Solute Carrier Family 22 Member 5; Symporters; Uric Acid; Urinary Tract Physiological Phenomena; Uromodulin | 2012 |
Factors associated with acute gout attacks in normouricaemic gout patients receiving allopurinol: a retrospective study.
Topics: Acute Disease; Aged; Allopurinol; Arthritis, Gouty; Gout; Gout Suppressants; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; Uric Acid | 2011 |
Hyperuricaemia and gout.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Diet; Gout; Gout Suppressants; Humans; Hyperuricemia; Immunity, Innate; Inflammation; Kidney; Membrane Transport Proteins; Standard of Care; Steroids; Uric Acid | 2011 |
Novel mutations in xanthine dehydrogenase/oxidase cause severe hypouricemia: biochemical and molecular genetic analysis in two Czech families with xanthinuria type I.
Topics: Adult; Base Sequence; Blotting, Western; Czech Republic; DNA Primers; Electrophoresis, Polyacrylamide Gel; Female; Haplotypes; Humans; Male; Microsatellite Repeats; Mutation; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2012 |
Elevated uric acid correlates with wound severity.
Topics: Aged; Blotting, Western; Chronic Disease; Exudates and Transudates; Humans; Leg Ulcer; Male; Middle Aged; Ultrafiltration; Uric Acid; Xanthine Oxidase | 2012 |
Effect of the treatment with allopurinol on the endothelial function in patients with hyperuricemia.
Topics: Adolescent; Adult; Aged; Allopurinol; Brachial Artery; Endothelium, Vascular; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Uric Acid; Vasodilation | 2012 |
Heroin affects purine nucleotides metabolism in rat brain.
Topics: Adenine Phosphoribosyltransferase; Adenosine Deaminase; Adenosine Kinase; Animals; Blood Urea Nitrogen; Brain; Creatinine; Heroin; Male; Purine Nucleotides; Purines; Rats; Rats, Wistar; Uric Acid; Xanthine Oxidase | 2011 |
Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans.
Topics: Arylamine N-Acetyltransferase; Asian People; Caffeine; Contraceptives, Oral; Genotype; Humans; Phenotype; Polymorphism, Single Nucleotide; Sex Factors; Uracil; Uric Acid; White People; Xanthine Oxidase; Xanthines | 2012 |
Use of uric acid-lowering agents limits experimental cyclosporine nephropathy.
Topics: Allopurinol; Animals; Benzbromarone; Cell Proliferation; Cyclosporine; Enzyme Inhibitors; Fibrosis; Hyperuricemia; Immunohistochemistry; Kidney; Kidney Diseases; Male; Osteopontin; Random Allocation; Rats; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Vascular Endothelial Growth Factor A; Xanthine Oxidase | 2012 |
Ultrahigh performance liquid chromatography-triple quadrupole mass spectrometry inhibitors fishing assay: a novel method for simultaneously screening of xanthine oxidase inhibitor and superoxide anion scavenger in a single analysis.
Topics: Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Enzyme Inhibitors; Formazans; Free Radical Scavengers; Limit of Detection; Superoxides; Tandem Mass Spectrometry; Tetrazolium Salts; Uric Acid; Xanthine; Xanthine Oxidase | 2012 |
An amperometric biosensor for fish freshness detection from xanthine oxidase immobilized in polypyrrole-polyvinylsulphonate film.
Topics: Animals; Biocatalysis; Biosensing Techniques; Electrochemistry; Electrodes; Enzymes, Immobilized; Fishes; Food Analysis; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hypoxanthine; Methylene Blue; Polymers; Polyvinyls; Pyrroles; Reproducibility of Results; Sulfonic Acids; Temperature; Uric Acid; Xanthine; Xanthine Oxidase | 2012 |
A role for xanthine oxidase in the control of fetal cardiovascular function in late gestation sheep.
Topics: Adrenergic beta-1 Receptor Antagonists; Allopurinol; Animals; Cardiovascular Physiological Phenomena; Cardiovascular System; Female; Fetus; Gestational Age; Heart Rate, Fetal; Nitric Oxide; Pregnancy; Pregnancy Complications; Regional Blood Flow; Sheep; Uric Acid; Xanthine Oxidase | 2012 |
Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia.
Topics: Allopurinol; Animals; Body Composition; Body Weight; Cachexia; Caspase 3; Enzyme Inhibitors; Male; Neoplasms; Oxidative Stress; Oxypurinol; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2012 |
Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.
Topics: Allopurinol; Animals; Blotting, Western; Carrier Proteins; Cholesterol; Creatinine; Dyslipidemias; Fructose; Glucose Tolerance Test; Hyperuricemia; Inflammasomes; Insulin Resistance; Kidney; Lipid Metabolism; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Quercetin; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Rutin; Uric Acid | 2012 |
Gouty arthritis and panniculitis: extensive involvement of the dermis and severe joint damage.
Topics: Adult; Allopurinol; Anti-Bacterial Agents; Arthritis, Gouty; Biopsy; Bone Cysts; Gout Suppressants; Humans; Joint Diseases; Male; Metatarsophalangeal Joint; Panniculitis; Radiography; Skin Diseases; Uric Acid | 2012 |
False-negative dual-energy computed tomography in a patient with acute gout.
Topics: Allopurinol; Arthralgia; Biopsy; False Negative Reactions; Gout; Gout Suppressants; Humans; Magnetic Resonance Imaging; Male; Metacarpophalangeal Joint; Middle Aged; Predictive Value of Tests; Synovial Fluid; Tomography, X-Ray Computed; Uric Acid | 2012 |
Starting dose is a risk factor for allopurinol hypersensitivity syndrome: a proposed safe starting dose of allopurinol.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Case-Control Studies; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Male; Middle Aged; Retrospective Studies; Risk Factors; ROC Curve; Syndrome; Uric Acid | 2012 |
The gout pipeline crystallizes.
Topics: Allopurinol; Anti-Inflammatory Agents; Clinical Trials, Phase III as Topic; Drug Industry; Gout; Gout Suppressants; Humans; Uric Acid | 2012 |
Colchicine use is associated with decreased prevalence of myocardial infarction in patients with gout.
Topics: Aged; Aged, 80 and over; Allopurinol; C-Reactive Protein; Colchicine; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Myocardial Infarction; New York; Prevalence; Retrospective Studies; Treatment Outcome; Uric Acid | 2012 |
In vitro effect of novel β-lactam compounds on xanthine oxidase enzyme activity.
Topics: Allopurinol; Animals; beta-Lactams; Carbazoles; Cattle; Enzyme Inhibitors; Ethylenes; Inhibitory Concentration 50; Ketones; Melanins; Milk; Uric Acid; Xanthine Oxidase | 2012 |
Uric acid, allopurinol therapy, and mortality in patients with acute heart failure--results of the Acute HEart FAilure Database registry.
Topics: Acute Disease; Age Factors; Aged; Aged, 80 and over; Allopurinol; Female; Glomerular Filtration Rate; Gout Suppressants; Heart Failure; Hospital Mortality; Humans; Hyperuricemia; Length of Stay; Male; Middle Aged; Natriuretic Peptide, Brain; Prognosis; Registries; Sex Factors; Uric Acid | 2012 |
Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation.
Topics: Acute Kidney Injury; Allopurinol; Analysis of Variance; Animals; Blood Urea Nitrogen; Blotting, Western; Body Weight; Carrier Proteins; Creatinine; Diabetic Nephropathies; DNA Primers; Gene Expression Regulation; Inflammasomes; Lipid Metabolism; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Organ Size; Quercetin; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytoplasmic and Nuclear; Streptozocin; Uric Acid | 2012 |
Hyperuricemia at 1 year after renal transplantation, its prevalence, associated factors, and graft survival.
Topics: Adult; Aged; Allopurinol; Female; Genotype; Glomerular Filtration Rate; Graft Survival; Humans; Hyperuricemia; Kidney Transplantation; Male; Middle Aged; Nitric Oxide Synthase Type III; Parathyroid Hormone; Prevalence; Time Factors; Uric Acid | 2012 |
Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Asteraceae; Ethanol; Flavonoids; Hyperuricemia; Inflammation; Liver; Male; Mice; Oxonic Acid; Phytotherapy; Plant Components, Aerial; Plant Extracts; Solvents; Uric Acid; Xanthine Oxidase | 2012 |
[Attack of gout].
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis, Gouty; Diagnosis, Differential; Gout; Gout Suppressants; Humans; Kidney Function Tests; Male; Middle Aged; Recurrence; Uric Acid | 2012 |
Achieving treat to target in gout: a clinical practice improvement project.
Topics: Adult; Aged; Allopurinol; Diet; Evidence-Based Medicine; Female; Gout; Gout Suppressants; Humans; Life Style; Male; Middle Aged; Patient Education as Topic; Practice Patterns, Physicians'; Prospective Studies; Quality Improvement; Self Care; Uric Acid | 2012 |
Casebook consults: improving outcomes in gout (multimedia activity).
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Febuxostat; Gout; Gout Suppressants; Humans; Long-Term Care; Medication Adherence; Referral and Consultation; Thiazoles; Uric Acid | 2012 |
Hypouricemic effect of the methanol extract from Prunus mume fruit in mice.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Hyperuricemia; Liver; Male; Medicine, East Asian Traditional; Methanol; Mice; Oxonic Acid; Plant Extracts; Prunus; Uric Acid; Xanthine Oxidase | 2012 |
Reducing effect of mangiferin on serum uric acid levels in mice.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Mice, Inbred Strains; Oxonic Acid; Time Factors; Toxicity Tests, Acute; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Xanthones | 2012 |
Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats.
Topics: Actins; Allopurinol; Animals; Anti-Inflammatory Agents; Benzbromarone; Chemokine CCL2; Cyclopentane Monoterpenes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glucosides; Immunologic Factors; Iridoid Glycosides; Kidney; Kidney Diseases; Male; Medicine, Chinese Traditional; Pyrans; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rubiaceae; Transcription Factor RelA; Uric Acid | 2012 |
Purinergic system in the treatment of bipolar disorder: uric acid levels as a screening test in mania.
Topics: Allopurinol; Antimanic Agents; Bipolar Disorder; Diagnostic Tests, Routine; Humans; Mass Screening; Uric Acid | 2012 |
Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase activity.
Topics: Allopurinol; Animals; Glucose Transporter Type 1; Gout; Gout Suppressants; Hyperuricemia; Hypoxanthine; Kidney; Liver; Male; Monosaccharide Transport Proteins; Oxonic Acid; Phytotherapy; Plant Extracts; Polyphenols; Rats; Rats, Sprague-Dawley; Sapindaceae; Seeds; Uric Acid; Xanthine Oxidase | 2012 |
Silkworms can be used as an animal model to screen and evaluate gouty therapeutic drugs.
Topics: Animals; Bombyx; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fat Body; Gout; Gout Suppressants; Hemolymph; Insect Proteins; Larva; Models, Animal; Uric Acid; Xanthine Oxidase | 2012 |
Changes in uric acid levels and allopurinol use in chronic heart failure: association with improved survival.
Topics: Aged; Allopurinol; Confidence Intervals; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Heart Failure; Humans; Length of Stay; Male; Prognosis; Prospective Studies; Regression Analysis; Risk Factors; Survival Analysis; Time Factors; Treatment Outcome; Uric Acid | 2012 |
Adherence to uric acid treatment guidelines in a rheumatology clinic.
Topics: Aged; Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Guideline Adherence; Humans; Male; Middle Aged; Probenecid; Retrospective Studies; Thiazoles; Treatment Outcome; Uric Acid | 2012 |
Prescription and dosing of urate-lowering therapy, rather than patient behaviours, are the key modifiable factors associated with targeting serum urate in gout.
Topics: Adult; Aged; Allopurinol; Biomarkers; Cross-Sectional Studies; Down-Regulation; Drug Dosage Calculations; Female; Gout; Gout Suppressants; Health Knowledge, Attitudes, Practice; Humans; Logistic Models; Male; Medication Adherence; Middle Aged; Odds Ratio; Surveys and Questionnaires; Treatment Outcome; Uric Acid | 2012 |
Oxidative stress produced by xanthine oxidase induces apoptosis in human extravillous trophoblast cells.
Topics: Apoptosis; Cell Differentiation; Cell Line; Cell Movement; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Developmental; Humans; Hydrogen Peroxide; Microscopy, Fluorescence; NG-Nitroarginine Methyl Ester; Oxidative Stress; Pregnancy; Trophoblasts; Uric Acid; Xanthine Oxidase | 2013 |
The influence of oxonate-induced hyperuricemia and allopurinol on behavioral reactions of random-bred mice.
Topics: Allopurinol; Animals; Behavior, Animal; Hindlimb Suspension; Male; Maze Learning; Mice; Motor Activity; Oxonic Acid; Uric Acid | 2012 |
Hyperuricemia in adult renal allograft recipients: prevalence and predictors.
Topics: Adult; Allopurinol; Biomarkers; Chi-Square Distribution; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Immunosuppressive Agents; Kidney Transplantation; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Portugal; Prevalence; Retrospective Studies; Risk Assessment; Risk Factors; Sex Factors; Treatment Outcome; Up-Regulation; Uric Acid | 2012 |
Xanthine oxidase-mediated denitrosation of N-nitroso-tryptophan by superoxide and uric acid.
Topics: Nitric Oxide; Nitrosamines; Superoxides; Tryptophan; Uric Acid; Xanthine Oxidase | 2013 |
Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.
Topics: Allopurinol; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Enzyme Inhibitors; Fatty Liver; Fructokinases; Fructose; Hep G2 Cells; Hepatocytes; Humans; Liver; Male; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Up-Regulation; Uric Acid | 2012 |
Pegloticase and the patient with treatment-failure gout.
Topics: Allopurinol; Enzymes, Immobilized; Female; Gout; Gout Suppressants; Humans; Infusions, Intravenous; Male; Polyethylene Glycols; Randomized Controlled Trials as Topic; Treatment Failure; Treatment Outcome; Urate Oxidase; Uric Acid | 2012 |
The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Biomarkers, Pharmacological; Disease Models, Animal; Edema; Hyperalgesia; Hyperuricemia; Jatropha; Male; Motor Activity; Neutrophil Infiltration; Oxonic Acid; Peroxidase; Phytotherapy; Plant Extracts; Rats; Stomach Ulcer; Uric Acid; Xanthine Oxidase | 2013 |
Integrating cellular metabolism into a multiscale whole-body model.
Topics: Acetaminophen; Allopurinol; Ammonia; Chemical and Drug Induced Liver Injury; Computational Biology; Computer Simulation; Hepatocytes; Humans; Hyperuricemia; Inactivation, Metabolic; Liver; Metabolism; Models, Biological; Urea; Urea Cycle Disorders, Inborn; Uric Acid | 2012 |
Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice.
Topics: Animals; Blood Chemical Analysis; Body Weight; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drugs, Chinese Herbal; Fructose; Glucosides; Inflammation; Interleukin-1beta; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Protective Agents; Stilbenes; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2013 |
A plasma oxidative stress global index in early stages of chronic venous insufficiency.
Topics: Adult; Advanced Oxidation Protein Products; Biomarkers; Case-Control Studies; Catalase; Chronic Disease; Disease Progression; Early Diagnosis; Female; Glutathione; Humans; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peroxidase; Predictive Value of Tests; Protein Carbonylation; Sulfhydryl Compounds; Tyrosine; Ultrasonography, Doppler, Color; Uric Acid; Veins; Venous Insufficiency; Xanthine Oxidase | 2013 |
Gouty panniculitis also involving the bone marrow.
Topics: Allopurinol; Biomarkers; Biopsy; Bone Marrow; Bone Marrow Examination; Colchicine; Crystallization; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Immunohistochemistry; Male; Middle Aged; Panniculitis; Predictive Value of Tests; Treatment Outcome; Uric Acid | 2013 |
Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury.
Topics: Acute Lung Injury; Adult; Allopurinol; Animals; Bronchoalveolar Lavage Fluid; Capillary Permeability; Carrier Proteins; Gene Expression Regulation; Humans; I-kappa B Proteins; Male; Mice; Mice, Inbred C57BL; Microvessels; NF-KappaB Inhibitor alpha; NLR Family, Pyrin Domain-Containing 3 Protein; Pulmonary Alveoli; Toll-Like Receptor 2; Toll-Like Receptor 4; Urate Oxidase; Uric Acid; Ventilator-Induced Lung Injury | 2012 |
Allopurinol versus rilonacept for the prevention of gout flares: comment on the article by Schumacher et al.
Topics: Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Recombinant Fusion Proteins; Uric Acid | 2013 |
Role of host xanthine oxidase in infection due to enteropathogenic and Shiga-toxigenic Escherichia coli.
Topics: Animals; Bodily Secretions; Cell Line; Disease Models, Animal; Enteropathogenic Escherichia coli; Escherichia coli Infections; Host-Pathogen Interactions; Humans; Hydrogen Peroxide; Intestines; Rabbits; Shiga-Toxigenic Escherichia coli; Uric Acid; Virulence; Xanthine Oxidase | 2013 |
Inhibition of UV-induced uric acid production using allopurinol prevents suppression of the contact hypersensitivity response.
Topics: Allopurinol; Animals; Apoptosis Regulatory Proteins; CARD Signaling Adaptor Proteins; Carrier Proteins; Cells, Cultured; Cytoskeletal Proteins; Dermatitis, Contact; Disease Models, Animal; Down-Regulation; Female; Gout Suppressants; Immunosuppression Therapy; In Vitro Techniques; Keratinocytes; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Skin; Ultraviolet Rays; Up-Regulation; Uric Acid | 2013 |
Effect of hypoxanthine, antioxidants and allopurinol on cholinesterase activities in rats.
Topics: Acetylcholinesterase; Allopurinol; alpha-Tocopherol; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Butyrylcholinesterase; Cholinesterases; Enzyme Inhibitors; Free Radicals; Hypoxanthine; Lesch-Nyhan Syndrome; Rats; Rats, Wistar; Uric Acid | 2013 |
Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training.
Topics: Adaptation, Physiological; Allopurinol; Animals; Enzyme Inhibitors; Glucose Transporter Type 4; Male; Mitochondria; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Skeletal; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenols; Physical Endurance; Physical Exertion; Plant Extracts; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Transcription Factors; Uric Acid; Xanthine; Xanthine Oxidase | 2013 |
High-dose prednisone in patients with heart failure and hyperuricemia: friend and foe?
Topics: Allopurinol; Female; Glucocorticoids; Gout Suppressants; Heart Failure; Humans; Hyperuricemia; Male; Prednisone; Uric Acid | 2013 |
Italian Society of Rheumatology recommendations for the management of gout.
Topics: Adrenal Cortex Hormones; Advisory Committees; Alcoholic Beverages; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Combined Modality Therapy; Dairy Products; Disease Management; Evidence-Based Medicine; Febuxostat; Female; Fructose; Gout; Humans; Italy; Male; Risk Factors; Smoking; Societies, Medical; Thiazoles; Uric Acid | 2013 |
Paradoxical increase in uric acid level with allopurinol use in pyrazinamide-induced hyperuricaemia.
Topics: Adult; Allopurinol; Arthritis, Psoriatic; Humans; Hyperuricemia; Male; Pyrazinamide; Treatment Outcome; Tuberculosis, Miliary; Uric Acid | 2013 |
Lead-elevated activity of xanthine oxidase in lead-exposed workers.
Topics: Adult; Biomarkers; Creatinine; Environmental Monitoring; Erythrocytes; Humans; Lead; Male; Malondialdehyde; Metallurgy; Middle Aged; Occupational Exposure; Oxidative Stress; Reference Values; Uric Acid; Xanthine Oxidase; Young Adult | 2013 |
Hypouricemic effects of prednisone and allopurinol: an uneven playing field?
Topics: Allopurinol; Female; Glucocorticoids; Gout Suppressants; Heart Failure; Humans; Hyperuricemia; Male; Prednisone; Uric Acid | 2014 |
Reply to Day et al.--hypouricemic effect of prednisone in heart failure: possible mechanisms.
Topics: Allopurinol; Female; Glucocorticoids; Gout Suppressants; Heart Failure; Humans; Hyperuricemia; Male; Prednisone; Uric Acid | 2014 |
Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease.
Topics: Animals; Bombyx; Disease Models, Animal; Mutation; Oxidative Stress; Parkinson Disease; Signal Transduction; Tyrosine 3-Monooxygenase; Uric Acid; Xanthine Oxidase | 2013 |
Serum uric acid levels and long-term outcomes in chronic kidney disease.
Topics: Aged; Allopurinol; Biomarkers; Cause of Death; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Japan; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Odds Ratio; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; Uric Acid | 2014 |
3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout.
Topics: Administration, Oral; Allopurinol; Animals; Antioxidants; Benzaldehydes; Catechols; Cell-Free System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Molybdenum; Reactive Oxygen Species; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2013 |
Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function.
Topics: Biomarkers; Confounding Factors, Epidemiologic; Creatinine; Enzyme Inhibitors; Female; Genetic Predisposition to Disease; Glomerular Filtration Rate; Humans; Kidney; Least-Squares Analysis; Linear Models; Male; Mendelian Randomization Analysis; Models, Genetic; Models, Statistical; Organic Anion Transporters; Phenotype; Polymorphism, Single Nucleotide; Principal Component Analysis; Recovery of Function; Renal Insufficiency, Chronic; Risk Factors; Treatment Outcome; United States; Up-Regulation; Uric Acid; White People; Xanthine Oxidase | 2014 |
Synthesis of pyrimidones and evaluation of their xanthine oxidase inhibitory and antioxidant activities.
Topics: Animals; Antioxidants; Enzyme Inhibitors; Free Radical Scavengers; Gout Suppressants; Humans; Lipid Peroxidation; Molecular Docking Simulation; Molecular Structure; Pyrimidinones; Rats; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2013 |
Febuxostat for treating allopurinol-resistant hyperuricemia in patients with chronic kidney disease.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Creatinine; Enzyme Inhibitors; Febuxostat; Glomerular Filtration Rate; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies; Thiazoles; Uric Acid | 2014 |
[Effect of total saponin of Dioscorea on chronic hyperuricemia and expression of URAT1 in rats].
Topics: Animals; Anion Transport Proteins; Benzbromarone; Dioscorea; Gout Suppressants; Hyperuricemia; Kidney Tubules; Male; Rats; Rats, Sprague-Dawley; Saponins; Uric Acid; Xanthine Oxidase | 2013 |
Biocompatible phosphonic acid-functionalized silica nanoparticles for sensitive detection of hypoxanthine in real samples.
Topics: Animals; Ascorbic Acid; Biocompatible Materials; Biosensing Techniques; Carbon; Carps; Electrochemical Techniques; Electrodes; Enzymes, Immobilized; Humans; Hypoxanthine; Limit of Detection; Milk; Nanoparticles; Phosphorous Acids; Signal-To-Noise Ratio; Silicon Dioxide; Uric Acid; Xanthine Oxidase | 2013 |
Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy.
Topics: Allopurinol; Animals; Blood Glucose; Blood Pressure; Enzyme Inhibitors; Female; Fetal Heart; Fetal Hypoxia; Gestational Age; Heart Rate; Lactic Acid; Nitric Oxide; Oxygen; Oxygen Consumption; Pregnancy; Reactive Oxygen Species; Regional Blood Flow; Sheep; Uric Acid; Vasoconstriction; Xanthine Oxidase | 2014 |
An audit of a therapeutic drug monitoring service for allopurinol therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Child; Child, Preschool; Creatinine; Drug Monitoring; Female; Gout; Gout Suppressants; Humans; Infant; Male; Medication Adherence; Middle Aged; Oxypurinol; Time Factors; Uric Acid; Young Adult | 2013 |
CaseBook challenges: Managing gout, hyperuricemia and comorbidities -- dialogue with the experts.
Topics: Allopurinol; Comorbidity; Disease Management; Drug Administration Schedule; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Medication Adherence; Primary Health Care; Risk Factors; Severity of Illness Index; Thiazoles; United States; Uric Acid | 2014 |
Lack of change in urate deposition by dual-energy computed tomography among clinically stable patients with long-standing tophaceous gout: a prospective longitudinal study.
Topics: Aged; Allopurinol; Female; Foot; Gout; Gout Suppressants; Humans; Male; Middle Aged; Prospective Studies; Reproducibility of Results; Tomography, X-Ray Computed; Uric Acid | 2013 |
Late diagnosis of Lesch-Nyhan disease variant.
Topics: Adult; Allopurinol; Diuretics; Genetic Counseling; Gout; Gout Suppressants; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Male; Nephrolithiasis; Potassium Citrate; Uric Acid | 2013 |
Association of serum uric acid and incident nonspine fractures in elderly men: the Osteoporotic Fractures in Men (MrOS) study.
Topics: Aged; Allopurinol; Bone Density; Cohort Studies; Gout; Hip Fractures; Humans; Incidence; Male; Osteoporotic Fractures; United States; Uric Acid | 2014 |
Pro-inflammatory effects of uric acid in the gastrointestinal tract.
Topics: Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Chemotaxis; Gastrointestinal Diseases; Gastrointestinal Tract; Hydrogen Peroxide; Immunity, Cellular; Inflammation Mediators; Leukocytes; Models, Animal; Rabbits; Uric Acid; Xanthine Oxidase | 2014 |
Gout in a 15-year-old boy with juvenile idiopathic arthritis: a case study.
Topics: Adolescent; Allopurinol; Ankle Joint; Arthritis, Gouty; Arthritis, Juvenile; Colchicine; Delayed Diagnosis; Diagnosis, Differential; Gout Suppressants; Humans; Magnetic Resonance Imaging; Male; Obesity; Orthopedic Procedures; Osteochondritis Dissecans; Severity of Illness Index; Time-to-Treatment; Treatment Failure; Uric Acid | 2014 |
Strategy to improve the request of uric acid in primary care: preliminary results and evaluation through process and outcome appropriateness indicators.
Topics: Allopurinol; Blood Glucose; Evaluation Studies as Topic; Health Status Indicators; Humans; Outcome Assessment, Health Care; Primary Health Care; Uric Acid | 2014 |
Identification of uric acid as the redox molecule secreted by the yeast Arxula adeninivorans.
Topics: Chromatography, High Pressure Liquid; Culture Media; Gene Deletion; Gene Expression; Mass Spectrometry; Metabolic Networks and Pathways; Nitrogen; Oxidation-Reduction; Purines; Saccharomycetales; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2014 |
Effectiveness of a pharmacist-based gout care management programme in a large integrated health plan: results from a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Ambulatory Care Facilities; Chronic Disease; Feasibility Studies; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Patient Care Planning; Pharmacy Service, Hospital; Pilot Projects; Treatment Outcome; Uric Acid | 2014 |
Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Blood Pressure; Creatinine; Disease Progression; Essential Hypertension; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Renal Dialysis; Urea; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2014 |
Assessment of the role of multidrug resistance-associated proteins in MPTP neurotoxicity in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Allopurinol; Animals; Brain; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Agents; Drug Administration Schedule; Flavanones; Homovanillic Acid; Infusions, Parenteral; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neurotoxins; Oxidative Stress; Parkinson Disease; Silymarin; Sulfinpyrazone; Uric Acid | 2013 |
Treatment of asymptomatic hyperuricemia and prevention of vascular disease: a decision analytic approach.
Topics: Aged; Allopurinol; Decision Support Techniques; Female; Follow-Up Studies; Gout Suppressants; Humans; Hyperuricemia; Male; Markov Chains; Middle Aged; Risk Assessment; Severity of Illness Index; Sex Factors; Treatment Outcome; Uric Acid; Vascular Diseases | 2014 |
Efficacy and safety of febuxostat in the treatment of hyperuricemia in stable kidney transplant recipients.
Topics: Adult; Aged; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kidney Transplantation; Male; Middle Aged; Practice Patterns, Physicians'; Retrospective Studies; Thiazoles; Uric Acid; Xanthine Oxidase | 2014 |
[Effect of jianpihuashi decoction on rats with hyperuricemia].
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Liver; Male; Oxonic Acid; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2013 |
Facilitators and barriers to adherence to urate-lowering therapy in African-Americans with gout: a qualitative study.
Topics: Aged; Allopurinol; Black or African American; Evaluation Studies as Topic; Febuxostat; Female; Focus Groups; Gout; Gout Suppressants; Health Knowledge, Attitudes, Practice; Humans; Male; Medication Adherence; Middle Aged; Thiazoles; Uric Acid | 2014 |
Allopurinol reduces levels of urate and dopamine but not dopaminergic neurons in a dual pesticide model of Parkinson's disease.
Topics: Allopurinol; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Enzyme Inhibitors; Male; Maneb; Mice; Mice, Inbred C57BL; Motor Activity; Paraquat; Parkinson Disease; Pesticides; Uric Acid | 2014 |
Achieving serum urate goal: a comparative effectiveness study between allopurinol and febuxostat.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Biomarkers; Comparative Effectiveness Research; Drug Administration Schedule; Febuxostat; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Logistic Models; Male; Middle Aged; Retrospective Studies; Thiazoles; Treatment Outcome; Uric Acid; Young Adult | 2014 |
Anakinra treatment in patients with gout and type 2 diabetes.
Topics: Aged; Aged, 80 and over; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Blood Glucose; Carbamates; Colchicine; Diabetes Mellitus, Type 2; Febuxostat; Glycated Hemoglobin; Gout; Gout Suppressants; Humans; Hyperuricemia; Hypoglycemic Agents; Insulin; Interleukin 1 Receptor Antagonist Protein; Metformin; Middle Aged; Piperidines; Treatment Outcome; Uric Acid | 2015 |
Drugs for gout.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Colchicine; Enzyme Inhibitors; Gout; Gout Suppressants; Humans; Interleukin-1; Secondary Prevention; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
In vitro xanthine oxidase inhibitory and in vivo hypouricemic activity of herbal coded formulation (Gouticin).
Topics: Allopurinol; Female; Gout; Humans; Male; Middle Aged; Phytotherapy; Plant Extracts; Plants, Medicinal; Uric Acid; Xanthine Oxidase | 2014 |
In vitro oxidative metabolism of 6-mercaptopurine in human liver: insights into the role of the molybdoflavoenzymes aldehyde oxidase, xanthine oxidase, and xanthine dehydrogenase.
Topics: Adult; Aged; Aldehyde Oxidase; Cytosol; Escherichia coli; Female; Humans; Liver; Male; Mercaptopurine; Metabolic Detoxication, Phase I; Middle Aged; Recombinant Proteins; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Young Adult | 2014 |
The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats.
Topics: Animals; Disease Models, Animal; Euonymus; Formaldehyde; Gardenia; Gout; Hyperuricemia; Nociception; Pain; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Rubia; Taiwan; Toxicity Tests; Uric Acid; Xanthine Oxidase | 2014 |
Prevention of comorbidity and acute attack of gout by uric acid lowering therapy.
Topics: Adult; Allopurinol; Antimetabolites; Benzbromarone; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hypertension; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies; Thiazoles; Uric Acid; Uricosuric Agents; Urolithiasis | 2014 |
Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
Topics: Animals; Creatinine; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Gene Expression Regulation; Hypertension; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxonic Acid; Phytotherapy; Plant Extracts; Rhizome; Uric Acid; Xanthine Oxidase | 2014 |
A new xanthine oxidase inhibitor: the uric acid reduction and additional efficacy in CKD patients.
Topics: Enzyme Inhibitors; Febuxostat; Humans; Hyperuricemia; Nitriles; Pyridines; Renal Insufficiency, Chronic; Thiazoles; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2014 |
The impact of elevation of serum uric acid level on the natural history of glomerular filtration rate (GFR) and its sex difference.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Female; Free Radical Scavengers; Glomerular Filtration Rate; Humans; Hyperuricemia; Longitudinal Studies; Male; Middle Aged; Retrospective Studies; Rural Population; Sex Factors; Uric Acid; Young Adult | 2014 |
False in vitro and in vivo elevations of uric acid levels in mouse blood.
Topics: Allopurinol; Animals; Blood Chemical Analysis; Blood Specimen Collection; False Positive Reactions; Male; Mice; Mice, Inbred ICR; Phentolamine; Time Factors; Uric Acid | 2014 |
Radiographic and laboratory data ("the Megaprofile") can accurately guide medical management in the absence of stone analysis.
Topics: Adult; Aged; Allopurinol; Anti-Bacterial Agents; Body Mass Index; Calcium Oxalate; Calcium Phosphates; Cohort Studies; Diet Therapy; Diuretics; Enzyme Inhibitors; Female; Humans; Magnesium Compounds; Male; Middle Aged; Phosphates; Potassium Citrate; Struvite; Thiazides; Time Factors; Uric Acid; Urinary Calculi; Urology | 2015 |
In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects.
Topics: Animals; Antioxidants; Chlorogenic Acid; Coix; Coumaric Acids; Enzyme Inhibitors; Free Radical Scavengers; Hyperuricemia; Male; Oxonic Acid; Phenols; Plant Extracts; Propionates; Rats; Rats, Sprague-Dawley; Seeds; Uric Acid; Xanthine Oxidase | 2014 |
Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis.
Topics: Animals; Cattle; Chrysanthemum; Flowers; Hyperuricemia; Liver; Male; Oligonucleotide Array Sequence Analysis; Plant Oils; Rats; Uric Acid; Xanthine Oxidase | 2014 |
Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Allopurinol; Disease Progression; Drug Substitution; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies; Thiazoles; Treatment Outcome; Uric Acid | 2014 |
X-ray crystal structure of a xanthine oxidase complex with the flavonoid inhibitor quercetin.
Topics: Animals; Antioxidants; Catalytic Domain; Cattle; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Molecular Conformation; Molecular Structure; Molybdenum; Phenylalanine; Quercetin; Structure-Activity Relationship; Uric Acid; Xanthine; Xanthine Oxidase | 2014 |
Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor, decreases serum uric acid levels in type 2 diabetic patients partly by suppressing xanthine oxidase activity.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hypoglycemic Agents; Linagliptin; Male; Middle Aged; Prospective Studies; Purines; Quinazolines; Uric Acid; Xanthine Oxidase | 2014 |
An insight into prototropism and supramolecular motifs in solid-state structures of allopurinol, hypoxanthine, xanthine, and uric acid. A ¹H-¹⁴N NQDR spectroscopy, hybrid DFT/QTAIM, and Hirshfeld surface-based study.
Topics: Allopurinol; Hydrogen; Hydrogen Bonding; Hypoxanthine; Magnetic Resonance Spectroscopy; Models, Molecular; Nitrogen; Quantum Theory; Uric Acid; Xanthine; Xanthine Oxidase | 2014 |
Effects of Smilaxchinoside A and Smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Glucose Transport Proteins, Facilitative; Glycosides; Hyperuricemia; Kidney; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Plant Roots; Saponins; Smilax; Steroids; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2014 |
Tumor lysis syndrome: risk factors, diagnosis, and management.
Topics: Allopurinol; Burkitt Lymphoma; Child; Creatinine; Electrolytes; Fluid Therapy; Gout Suppressants; Humans; Kidney; Male; Risk Assessment; Risk Factors; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2014 |
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.
Topics: Allopurinol; Animals; Body Composition; Calorimetry; Echocardiography; Enterocytes; Glucose Transport Proteins, Facilitative; Hyperuricemia; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Knockout; Uric Acid; Xanthine Oxidase | 2014 |
Allopurinol initiation and change in blood pressure in older adults with hypertension.
Topics: Age Factors; Aged; Allopurinol; Blood Pressure; Case-Control Studies; Databases, Factual; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Regression Analysis; Treatment Outcome; United Kingdom; Uric Acid; Xanthine Oxidase | 2014 |
Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function.
Topics: Allopurinol; Animals; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Lipopolysaccharides; Liver; Male; MCF-7 Cells; Mice; Myeloid Cells; Peptidoglycan; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; RNA Interference; RNA, Small Interfering; Stem Cell Factor; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptor 7; Toll-Like Receptor 8; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Tungsten Compounds; Uric Acid; Xanthine Oxidase | 2014 |
Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia.
Topics: Advanced Oxidation Protein Products; Allopurinol; Animals; Antigens, CD34; Biomarkers; Bone Marrow; Disease Models, Animal; Hyperuricemia; Lipoproteins, HDL; Milk; Oxidative Stress; Purines; Rats; Stem Cells; Uric Acid | 2014 |
The impact of Ramadan fast on patients with gout.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Body Mass Index; Case-Control Studies; Colchicine; Creatinine; Fasting; Female; Gout; Gout Suppressants; Humans; Islam; Israel; Male; Middle Aged; Patient Compliance; Urea; Uric Acid | 2014 |
Effects of chicory inulin on serum metabolites of uric acid, lipids, glucose, and abdominal fat deposition in quails induced by purine-rich diets.
Topics: Abdominal Fat; Acetyl-CoA Carboxylase; Animals; Blood Glucose; Cichorium intybus; Diet; Disease Models, Animal; Hypertriglyceridemia; Hyperuricemia; Inulin; Lipids; Male; Obesity, Abdominal; Phytotherapy; Plant Extracts; Purines; Quail; Uric Acid; Xanthine Oxidase | 2014 |
Effects of uric acid on hearts of rats with chronic kidney disease.
Topics: Allopurinol; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Gout Suppressants; Heart Diseases; Hyperuricemia; Male; Myocardium; Random Allocation; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Uric Acid | 2014 |
Modern diagnostic approach to hereditary xanthinuria.
Topics: Allopurinol; Child; Child, Preschool; Female; Humans; Male; Metabolism, Inborn Errors; Metabolomics; Uric Acid; Xanthine Dehydrogenase | 2015 |
Influence of urate-lowering therapies on renal handling of uric acid.
Topics: Adult; Antihypertensive Agents; Benzbromarone; Case-Control Studies; Creatinine; Glomerular Filtration Rate; Gout; Humans; Hypertension; Kidney; Logistic Models; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2016 |
Study on the anti-gout activity of chlorogenic acid: improvement on hyperuricemia and gouty inflammation.
Topics: Animals; Chlorogenic Acid; Cytokines; Disease Models, Animal; Gout; Gout Suppressants; Hyperuricemia; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Mice, Inbred Strains; Phytotherapy; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2014 |
Adherence and persistence to urate-lowering therapies in the Irish setting.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Allopurinol; Databases, Factual; Febuxostat; Female; Gout; Gout Suppressants; Humans; Ireland; Male; Medication Adherence; Middle Aged; Retrospective Studies; Sex Factors; Uric Acid; Young Adult | 2016 |
Gout, allopurinol intake and clinical outcomes in the hospitalized multimorbid elderly.
Topics: Age Factors; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Chronic Disease; Comorbidity; Female; Gout; Hospital Mortality; Hospitalization; Humans; Hyperuricemia; Kidney Diseases; Length of Stay; Male; Treatment Outcome; Uric Acid | 2014 |
The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Death; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Enzyme Inhibitors; Febuxostat; Gastroesophageal Reflux; Gout Suppressants; Liver; Lung; Lung Injury; Male; Mice, Inbred C57BL; Necrosis; Neutrophil Infiltration; Peritoneum; Peritonitis; Thiazoles; Uric Acid; Xanthine Oxidase | 2015 |
Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice.
Topics: Aging; Allopurinol; Animal Feed; Animals; Apolipoproteins E; Arteriosclerosis; Benzbromarone; Diet; Gene Expression Regulation; Gout Suppressants; Hyperuricemia; Male; Mice; Mice, Knockout; Risk Factors; Uric Acid; Uricosuric Agents | 2014 |
Uric acid promotes left ventricular diastolic dysfunction in mice fed a Western diet.
Topics: Allopurinol; Animals; Biomarkers; Diet, Western; Dietary Fats; Dietary Sucrose; Disease Models, Animal; Fibrosis; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Myocardium; Oxidative Stress; Signal Transduction; Uric Acid; Ventricular Dysfunction, Left; Xanthine Oxidase | 2015 |
Effects of extracts of leaves from Sparattosperma leucanthum on hyperuricemia and gouty arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Bignoniaceae; Gout Suppressants; Hyperuricemia; Liver; Male; Mice; Oxonic Acid; Phytotherapy; Plant Extracts; Plant Leaves; Uric Acid; Xanthine Oxidase | 2015 |
Health literacy in patients dealing with gout: a qualitative study.
Topics: Aged; Aged, 80 and over; Allopurinol; Female; Gout; Gout Suppressants; Health Literacy; Humans; Interviews as Topic; Male; Medication Adherence; Middle Aged; Perception; Professional-Patient Relations; Qualitative Research; Uric Acid | 2015 |
Febuxostat for management of tumor lysis syndrome including its effects on levels of purine metabolites in patients with hematological malignancies - a single institution's, pharmacokinetic and pilot prospective study.
Topics: Aged; Allopurinol; Antineoplastic Agents; Creatinine; Enzyme Inhibitors; Febuxostat; Female; Glomerular Filtration Rate; Hematologic Neoplasms; Humans; Hypoxanthine; Male; Middle Aged; Pilot Projects; Prospective Studies; Thiazoles; Tumor Lysis Syndrome; Uric Acid; Xanthine; Xanthine Oxidase | 2014 |
Modifiable factors associated with allopurinol adherence and outcomes among patients with gout in an integrated healthcare system.
Topics: Aged; Allopurinol; Databases, Factual; Delivery of Health Care, Integrated; Female; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Middle Aged; Retrospective Studies; Treatment Outcome; Uric Acid | 2015 |
[CORRECTION OF BILE FLOW CHARACTERISTICS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH HYPERURICEMIA].
Topics: Adult; Allopurinol; Bile; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Cholesterol; Cholic Acid; Deoxycholic Acid; Drug Therapy, Combination; Duodenoscopy; Female; Fluorobenzenes; Humans; Hyperuricemia; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Taurocholic Acid; Uric Acid; Ursodeoxycholic Acid | 2014 |
Allopurinol use and risk of non-fatal acute myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Case-Control Studies; Female; Free Radical Scavengers; Gout; Humans; Hyperuricemia; Male; Middle Aged; Myocardial Infarction; Risk Factors; Uric Acid | 2015 |
Cost-effectiveness analysis of allopurinol versus febuxostat in chronic gout patients: a U.S. payer perspective.
Topics: Allopurinol; Chronic Disease; Cost-Benefit Analysis; Febuxostat; Gout; Gout Suppressants; Humans; Markov Chains; Thiazoles; Uric Acid | 2015 |
Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Chromatography, High Pressure Liquid; Drug Synergism; Drugs, Chinese Herbal; Gene Expression Regulation; Glucose Transport Proteins, Facilitative; Hyperuricemia; Kidney; Mice; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Phytotherapy; Saponins; Smilax; Uric Acid | 2015 |
Xanthine oxidase in non-alcoholic fatty liver disease and hyperuricemia: One stone hits two birds.
Topics: Adult; Animals; Carrier Proteins; Cohort Studies; Disease Models, Animal; Female; Gene Knockdown Techniques; Hep G2 Cells; Humans; Hyperuricemia; Inflammasomes; Lipid Metabolism; Male; Mice; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Prospective Studies; Risk Factors; Uric Acid; Xanthine Oxidase | 2015 |
Metabonomics revealed xanthine oxidase-induced oxidative stress and inflammation in the pathogenesis of diabetic nephropathy.
Topics: Allantoin; Animals; Diabetic Nephropathies; Humans; Kidney; Magnetic Resonance Spectroscopy; Male; Metabolomics; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2015 |
Allopurinol adherence among patients with gout: an Italian general practice database study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Databases, Factual; Dose-Response Relationship, Drug; Female; Follow-Up Studies; General Practice; Gout; Gout Suppressants; Humans; Incidence; Italy; Male; Middle Aged; Patient Compliance; Retrospective Studies; Time Factors; Uric Acid; Young Adult | 2015 |
Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.
Topics: Animals; Binding Sites; Drug Design; Enzyme Inhibitors; Half-Life; Hydrophobic and Hydrophilic Interactions; Indoles; Microsomes, Liver; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Uric Acid; Xanthine Oxidase | 2015 |
Characteristics and management of gout patients in Europe: data from a large cohort of patients.
Topics: Adult; Allopurinol; Cohort Studies; Comorbidity; Cross-Sectional Studies; Europe; Febuxostat; Female; France; Gout; Gout Suppressants; Greece; Humans; Male; Middle Aged; Obesity; Patient Compliance; Thiazoles; Uric Acid | 2015 |
Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy.
Topics: Allopurinol; Animals; Anion Transport Proteins; Cell Line; Disease Models, Animal; Endocytosis; Intracellular Signaling Peptides and Proteins; Kidney Diseases; Lysosomes; Male; Rats, Sprague-Dawley; Uric Acid | 2015 |
Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation.
Topics: Animals; Autophagy; Blotting, Western; Calcium; Calcium Phosphates; Carrier Proteins; Caspase 1; Gene Knockdown Techniques; In Vitro Techniques; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Monocytes; NLR Family, Pyrin Domain-Containing 3 Protein; Peritonitis; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2015 |
Xanthine oxidase inhibition alleviates the cardiac complications of insulin resistance: effect on low grade inflammation and the angiotensin system.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Animals; Diet, High-Fat; Electrocardiography; Enzyme Inhibitors; Hemodynamics; Inflammation; Insulin Resistance; Isoproterenol; Male; Myocardial Ischemia; Myocardium; Oxidative Stress; Rats, Wistar; Ultrasonography; Uric Acid; Xanthine Oxidase | 2015 |
[Regulatory effect of leonurus extracts on hyperuricemia in rats].
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Hyperuricemia; Kidney; Leonurus; Male; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Up-Regulation; Uric Acid | 2014 |
Traditional Uighur Medicine Karapxa decoction, inhibits liver xanthine oxidase and reduces serum uric acid concentrations in hyperuricemic mice and scavenges free radicals in vitro.
Topics: Animals; Apiaceae; Asteraceae; Convolvulaceae; Free Radicals; Hyperuricemia; Liver; Medicine, Traditional; Mice; Phytotherapy; Plant Extracts; Uric Acid; Xanthine Oxidase | 2015 |
Effects of Febuxostat on Oxidative Stress.
Topics: Adult; Aged; Allopurinol; Creatinine; Enzyme Inhibitors; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Uric Acid | 2015 |
Comparative effectiveness of urate lowering with febuxostat versus allopurinol in gout: analyses from large U.S. managed care cohort.
Topics: Aged; Allopurinol; Cohort Studies; Cost-Benefit Analysis; Creatinine; Dose-Response Relationship, Drug; Drug Administration Schedule; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Managed Care Programs; Medicare; Reference Values; Retrospective Studies; Severity of Illness Index; Treatment Outcome; United States; Uric Acid | 2015 |
Using Next-Generation Sequencing to Identify a Mutation in Human MCSU that is Responsible for Type II Xanthinuria.
Topics: Adult; Aldehyde Oxidase; High-Throughput Nucleotide Sequencing; Humans; Male; Mutation; Purine-Pyrimidine Metabolism, Inborn Errors; Sulfurtransferases; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2015 |
The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model.
Topics: Animals; Apoptosis; Choline Deficiency; Cytoprotection; Diet, High-Fat; Enzyme Inhibitors; Febuxostat; Gout Suppressants; Hyperuricemia; Liver; Liver Cirrhosis, Experimental; Methionine; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thiazoles; Uric Acid; Xanthine Oxidase | 2015 |
Discovery of xanthine oxidase inhibitors and/or α-glucosidase inhibitors by carboxyalkyl derivatization based on the flavonoid of apigenin.
Topics: alpha-Glucosidases; Animals; Apigenin; Disease Models, Animal; Drug Evaluation, Preclinical; Flavonoids; Glucose Tolerance Test; Glycoside Hydrolase Inhibitors; Hyperuricemia; Hypoglycemic Agents; Infusions, Parenteral; Mice; Protein Binding; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2015 |
Urate synthesis and oxidative stress in phenytoin hepatotoxicity: the role of antioxidant vitamins.
Topics: Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Folic Acid; Liver; Oxidative Stress; Phenytoin; Rats, Wistar; Superoxides; Uric Acid; Vitamin E; Xanthine Oxidase | 2014 |
Gout: cartoonized and bagatellized and still left untreated. Time to change.
Topics: Allopurinol; Arthritis; Cartoons as Topic; Gout; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Inflammation; Uric Acid | 2015 |
Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice.
Topics: Allopurinol; Animals; Creatinine; Disease Models, Animal; Drug Synergism; Glucose Transport Proteins, Facilitative; Glycosides; Gout Suppressants; Hyperuricemia; Male; Mice; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Saponins; Smilax; Uric Acid; Xanthine Oxidase | 2015 |
Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Topics: Adenosine Triphosphate; Adjuvants, Pharmaceutic; Allopurinol; Animals; Antimetabolites; Cells, Cultured; Disease Models, Animal; Fatty Liver, Alcoholic; Female; Hepatocytes; Inflammasomes; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Probenecid; Signal Transduction; Uric Acid | 2015 |
Elevated level of renal xanthine oxidase mRNA transcription after nephropathogenic infectious bronchitis virus infection in growing layers.
Topics: Animals; Antioxidants; Chickens; Coronavirus Infections; Female; Infectious bronchitis virus; Kidney; Poultry Diseases; Real-Time Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Uric Acid; Xanthine Oxidase | 2015 |
Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
Topics: Aging; Allopurinol; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Caco-2 Cells; Dimerization; Enzyme Induction; Enzyme Inhibitors; Gout Suppressants; Humans; Hyperuricemia; Hypoxanthine; Ileum; Inosine; Intestinal Elimination; Intestinal Mucosa; Male; Mitochondria; Neoplasm Proteins; Rats, Wistar; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 2015 |
Is Hyperuricemia Overlooked when Treating Pediatric Tuberculosis Patients with Pyrazinamide?
Topics: Adolescent; Allopurinol; Antitubercular Agents; Child; Child, Preschool; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hyperuricemia; Male; Mycobacterium tuberculosis; Pyrazinamide; Retrospective Studies; Treatment Outcome; Tuberculosis; Uric Acid | 2015 |
[Time course of changes in the clinical manifestations of gout in men: data of a 7-year retrospective follow-up].
Topics: Adult; Aged; Allopurinol; Arthritis, Gouty; Follow-Up Studies; Gout; Gout Suppressants; Humans; Middle Aged; Remission Induction; Retrospective Studies; Time Factors; Uric Acid | 2015 |
Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricemia.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Platelets; Carotid Artery Thrombosis; Case-Control Studies; Cell-Derived Microparticles; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Interleukin-6; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 2015 |
Update on the diagnosis and management of gout.
Topics: Allopurinol; Anti-Inflammatory Agents; Diagnostic Imaging; Gout; Humans; Synovial Fluid; Uric Acid | 2015 |
Hyperuricemia is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes.
Topics: Aged; Aged, 80 and over; Allopurinol; Atrial Fibrillation; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Electronic Health Records; Female; Gout; Gout Suppressants; Hospitalization; Hospitals, University; Humans; Hyperuricemia; Italy; Male; Middle Aged; Prevalence; Retrospective Studies; Risk; Uric Acid | 2016 |
In vitro Xanthine Oxidase Inhibitory Studies of Lippia nodiflora and Isolated Flavonoids and Phenylethanoid Glycosides as Potential Uric Acid-lowering Agents.
Topics: Flavonoids; Glycosides; Humans; Hyperuricemia; Lippia; Models, Biological; Plant Extracts; Plant Leaves; Uric Acid; Xanthine Oxidase | 2015 |
Effects of anthocyanins from purple sweet potato (Ipomoea batatas L. cultivar Eshu No. 8) on the serum uric acid level and xanthine oxidase activity in hyperuricemic mice.
Topics: Animals; Anthocyanins; Glucose Transport Proteins, Facilitative; Humans; Hyperuricemia; Ipomoea batatas; Kidney; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Plant Extracts; Uric Acid; Xanthine Oxidase | 2015 |
[Establishment of double targets of high throughput screening model for xanthine oxidase inhibitors and superoxide anion scavengers].
Topics: Enzyme Inhibitors; Free Radical Scavengers; High-Throughput Screening Assays; Superoxides; Uric Acid; Xanthine; Xanthine Oxidase | 2015 |
The Effects of Xanthine Oxidoreductase Inhibitors on Oxidative Stress Markers following Global Brain Ischemia Reperfusion Injury in C57BL/6 Mice.
Topics: Aldehydes; Allopurinol; Animals; Biomarkers; Brain; Brain Ischemia; Disease Models, Animal; Interleukin-1beta; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Reactive Oxygen Species; Reperfusion Injury; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Uric Acid; Xanthine Dehydrogenase | 2015 |
An Observational Study of Gout Prevalence and Quality of Care in a National Australian General Practice Population.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Allopurinol; Australia; Electronic Health Records; Female; General Practice; Gout; Gout Suppressants; Humans; Male; Middle Aged; Prevalence; Quality of Health Care; Sex Factors; Uric Acid; Young Adult | 2015 |
[Dual-energy computer tomography can be used for gout diagnostics].
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Male; Middle Aged; Radiography, Dual-Energy Scanned Projection; Tomography, X-Ray Computed; Uric Acid; Wrist Joint | 2015 |
Increase in thyroid stimulating hormone levels in patients with gout treated with inhibitors of xanthine oxidoreductase.
Topics: Aged; Allopurinol; Biomarkers; Enzyme Inhibitors; Febuxostat; Female; Gout; Gout Suppressants; Humans; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Thyrotropin; Time Factors; Treatment Outcome; Up-Regulation; Uric Acid; Xanthine Dehydrogenase | 2015 |
Green tea polyphenols decreases uric acid level through xanthine oxidase and renal urate transporters in hyperuricemic mice.
Topics: Animals; Gout Suppressants; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Polyphenols; Tea; Uric Acid; Xanthine Oxidase | 2015 |
The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia.
Topics: Adult; Allantoin; Arterial Pressure; Case-Control Studies; Female; Humans; Hypertension; Nitrites; Pre-Eclampsia; Predictive Value of Tests; Pregnancy; ROC Curve; Severity of Illness Index; Uric Acid; Xanthine Oxidase; Young Adult | 2016 |
Outcome of Treatment in Gouty Arthritis Patients: A Retrospective Study.
Topics: Alcohol Drinking; Allopurinol; Arthritis, Gouty; Benzbromarone; Female; Follow-Up Studies; Gout Suppressants; Humans; Kidney Function Tests; Male; Middle Aged; Retrospective Studies; Risk Factors; Treatment Outcome; Uric Acid; Uricosuric Agents | 2015 |
Antidepressant-like effects of the xanthine oxidase enzyme inhibitor allopurinol in rats. A comparison with fluoxetine.
Topics: Allopurinol; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Drug Therapy, Combination; Enzyme Inhibitors; Fluoxetine; Hydroxyindoleacetic Acid; Male; Motor Activity; Rats; Rats, Wistar; Serotonin; Swimming; Uric Acid; Xanthine Oxidase | 2015 |
[The Xanthine Oxidase Inhibitory Activity and Hypouricemic Effects of Crude Drugs Obtained from the Silkworm in Mice].
Topics: Administration, Oral; Animals; Biological Products; Biomarkers; Blood Pressure; Bombyx; Chromatography, High Pressure Liquid; Complex Mixtures; Dermatitis, Contact; Disease Models, Animal; Enzyme Inhibitors; Hyperuricemia; Mice; Oxonic Acid; Platelet Aggregation; Uric Acid; Xanthine Oxidase | 2015 |
Plasma Xanthine Oxidase Activity Is Predictive of Cardiovascular Disease in Patients with Chronic Kidney Disease, Independently of Uric Acid Levels.
Topics: Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Longitudinal Studies; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Predictive Value of Tests; Prospective Studies; Purines; Renal Dialysis; Renal Insufficiency, Chronic; Risk Factors; Uric Acid; Xanthine Oxidase | 2015 |
Predicting allopurinol response in patients with gout.
Topics: Allopurinol; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Models, Biological; Oxypurinol; Predictive Value of Tests; Uric Acid | 2016 |
Significance of the initiation time of urate-lowering therapy in gout patients: A retrospective research.
Topics: Adult; Allopurinol; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Recurrence; Retrospective Studies; Time Factors; Treatment Outcome; Uric Acid | 2015 |
Is allopurinol use associated with an excess risk of osteoporotic fracture? A National Prescription Registry study.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Denmark; Female; Gout; Gout Suppressants; Hip Fractures; Humans; Male; Matched-Pair Analysis; Middle Aged; Osteoporotic Fractures; Propensity Score; Proportional Hazards Models; Registries; Risk Factors; Uric Acid | 2015 |
Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate.
Topics: Adenine; Administration, Oral; Animals; Benzbromarone; Creatinine; Drug Synergism; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Plant Exudates; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2015 |
Febuxostat in the management of gout: a cost-effectiveness analysis.
Topics: Adult; Aged; Allopurinol; Cost-Benefit Analysis; Disease Management; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; United States; Uric Acid | 2016 |
A Real-World Study of Switching From Allopurinol to Febuxostat in a Health Plan Database.
Topics: Adult; Aged; Allopurinol; Comparative Effectiveness Research; Drug Monitoring; Drug Substitution; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Retrospective Studies; Treatment Outcome; United States; Uric Acid; Xanthine Oxidase | 2015 |
Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action.
Topics: Animals; Flavonoids; Glycosides; Gout Suppressants; Hyperuricemia; Lippia; Liver; Male; Plant Extracts; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2015 |
Effect of xanthine oxidase inhibitors on the renal clearance of uric acid and creatinine.
Topics: Creatinine; Gout Suppressants; Humans; Hypertension; Uric Acid; Xanthine Oxidase | 2016 |
Impact of Urate Level on Cardiovascular Risk in Allopurinol Treated Patients. A Nested Case-Control Study.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Cardiovascular Diseases; Case-Control Studies; Denmark; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Odds Ratio; Reproducibility of Results; Risk Factors; Treatment Outcome; Uric Acid | 2016 |
Structure-based design and biological evaluation of novel 2-(indol-2-yl) thiazole derivatives as xanthine oxidase inhibitors.
Topics: Administration, Oral; Animals; Binding Sites; Cattle; Drug Design; Enzyme Inhibitors; Half-Life; Hyperuricemia; Microsomes, Liver; Molecular Docking Simulation; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles; Uric Acid; Xanthine Oxidase | 2016 |
Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action.
Topics: Animals; Anti-Inflammatory Agents; Gout; Gout Suppressants; Hyperuricemia; Male; Mice; Phytotherapy; Pimenta; Plant Extracts; Plant Leaves; Rats, Wistar; Uric Acid; Xanthine Oxidase | 2016 |
Biological Activities of Uric Acid in Infection Due to Enteropathogenic and Shiga-Toxigenic Escherichia coli.
Topics: Animals; Cell Line; Colforsin; Enterohemorrhagic Escherichia coli; Escherichia coli Infections; Gastrointestinal Hormones; Humans; Intestines; Natriuretic Peptides; Rabbits; Shiga-Toxigenic Escherichia coli; Uric Acid; Xanthine Oxidase | 2016 |
ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biomarkers; Female; Gene Frequency; Genotype; Gout; Gout Suppressants; Humans; Logistic Models; Male; Middle Aged; Neoplasm Proteins; Odds Ratio; Oxypurinol; Pharmacogenetics; Pharmacogenomic Variants; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Treatment Outcome; Uric Acid; Young Adult | 2017 |
Miracle Fruit (Synsepalum dulcificum) Exhibits as a Novel Anti-Hyperuricaemia Agent.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Butanols; Disease Models, Animal; Hyperuricemia; Macrophages; Mice; Mice, Inbred ICR; Plant Extracts; RAW 264.7 Cells; Synsepalum; Uric Acid; Xanthine Oxidase | 2016 |
Weight Loss, Xanthine Oxidase, and Serum Urate Levels: A Prospective Longitudinal Study of Obese Patients.
Topics: Adult; Bariatric Surgery; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hyperuricemia; Longitudinal Studies; Male; Obesity; Prospective Studies; Uric Acid; Weight Loss; Xanthine Oxidase | 2016 |
Antihyperuricemic effects of thiadiazolopyrimidin-5-one analogues in oxonate treated rats.
Topics: Animals; Catalytic Domain; Creatinine; Enzyme Inhibitors; Hyperuricemia; Kidney; Liver; Male; Molecular Docking Simulation; Oxonic Acid; Rats; Rats, Wistar; Thiadiazoles; Uric Acid; Xanthine Oxidase | 2016 |
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity.
Topics: Administration, Oral; Animals; Biomarkers; Biotransformation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Gout Suppressants; Hyperuricemia; Kinetics; Mice; Molecular Structure; Oxonic Acid; Structure-Activity Relationship; Uric Acid; Xanthenes; Xanthine Oxidase; Xanthones | 2016 |
Suppression of superoxide anion generation catalyzed by xanthine oxidase with alkyl caffeates and the scavenging activity.
Topics: Caffeic Acids; Free Radical Scavengers; Molecular Structure; Reactive Oxygen Species; Superoxides; Uric Acid; Xanthine Oxidase | 2016 |
Prevalence and possible causes of hypouricemia at a tertiary care hospital.
Topics: Adult; Aged; Allopurinol; Angiotensin Receptor Antagonists; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Neoplasms; Prevalence; Republic of Korea; Risk Factors; Tertiary Care Centers; Uric Acid | 2016 |
Allopurinol ameliorates cardiac function in non-hyperuricaemic patients with chronic heart failure.
Topics: Adult; Aged; Allopurinol; Biomarkers; Chronic Disease; Female; Follow-Up Studies; Heart Failure; Humans; Hyperuricemia; Male; Middle Aged; Natriuretic Peptide, Brain; Uric Acid; Vasodilation; Ventricular Function, Left | 2016 |
Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.
Topics: Adolescent; Blood Pressure; Caloric Restriction; Female; Humans; Hypertension; Male; Minnesota; Obesity, Morbid; Pediatric Obesity; Risk Factors; Uric Acid; Weight Loss; Xanthine Oxidase | 2016 |
[Drug reduction of uric acid not just when symptoms appear].
Topics: Allopurinol; Clinical Trials as Topic; Febuxostat; Gout; Humans; Hyperuricemia; Uric Acid | 2016 |
Increased xanthine oxidase-related ROS production and TRPV1 synthesis preceding DOMS post-eccentric exercise in rats.
Topics: Animals; Antioxidants; Calcium-Transporting ATPases; Hand Strength; Hyperalgesia; Male; Muscle, Skeletal; Myalgia; Physical Exertion; Protein Carbonylation; Rats; Rats, Wistar; Reactive Oxygen Species; Running; TRPV Cation Channels; Uric Acid; Xanthine Oxidase | 2016 |
Cost Comparison of Urate-Lowering Therapies in Patients with Gout and Moderate-to-Severe Chronic Kidney Disease.
Topics: Aged; Aged, 80 and over; Allopurinol; Cohort Studies; Cost-Benefit Analysis; Febuxostat; Female; Gout; Gout Suppressants; Health Care Costs; Humans; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies; Severity of Illness Index; Uric Acid | 2016 |
Effects of xanthine oxidase inhibitors on renal function and blood pressure in hypertensive patients with hyperuricemia.
Topics: Aged; Allopurinol; Blood Pressure; Enzyme Inhibitors; Febuxostat; Female; Glomerular Filtration Rate; Humans; Hypertension; Hyperuricemia; Kidney; Male; Middle Aged; Renin-Angiotensin System; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2016 |
Maternal fructose drives placental uric acid production leading to adverse fetal outcomes.
Topics: Allopurinol; AMP Deaminase; Animals; Disease Models, Animal; Female; Fetal Growth Retardation; Fructose; Mice; Oxidative Stress; Placenta; Placental Insufficiency; Pregnancy; Triglycerides; Uric Acid; Xanthine Oxidase | 2016 |
Effects of urate-lowering agents on arrhythmia vulnerability in post-infarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Febuxostat; GAP-43 Protein; Male; Myocardial Infarction; Myocardium; Nerve Growth Factor; Rats; Rats, Wistar; Superoxides; Tyrosine 3-Monooxygenase; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2016 |
Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts.
Topics: Biocatalysis; High-Throughput Screening Assays; Hypoxanthine; Molecular Structure; Spectrum Analysis, Raman; Surface Properties; Uric Acid; Xanthine; Xanthine Oxidase | 2016 |
Mechanism-based pharmacokinetic-pharmacodynamic modeling of salvianolic acid A effects on plasma xanthine oxidase activity and uric acid levels in acute myocardial infarction rats.
Topics: Animals; Caffeic Acids; Chromatography, High Pressure Liquid; Lactates; Models, Biological; Myocardial Infarction; Pharmacokinetics; Plasma; Rats; Uric Acid; Xanthine Oxidase | 2017 |
Effect of Soy Sauce on Serum Uric Acid Levels in Hyperuricemic Rats and Identification of Flazin as a Potent Xanthine Oxidase Inhibitor.
Topics: Animals; Body Weight; Carbolines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Furans; Hyperuricemia; Male; Molecular Docking Simulation; Oxonic Acid; Rats, Sprague-Dawley; Soy Foods; Uric Acid; Xanthine Oxidase | 2016 |
Febuxostat for Asymptomatic Hyperuricemia in CKD.
Topics: Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Renal Insufficiency, Chronic; Thiazoles; Uric Acid; Xanthine Oxidase | 2016 |
Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits.
Topics: Animals; Antioxidants; Brain; Carbon Monoxide; Carbon Monoxide Poisoning; Central Nervous System; Humans; Hypoxanthine; Hypoxia; Microdialysis; Models, Theoretical; Nitric Oxide; Oxygen; Rats; Reactive Oxygen Species; Reperfusion Injury; Superoxides; Uric Acid; Xanthine Oxidase | 2016 |
Modeling and Simulation for Estimating the Influence of Renal Dysfunction on the Hypouricemic Effect of Febuxostat in Hyperuricemic Patients Due to Overproduction or Underexcretion of Uric Acid.
Topics: Computer Simulation; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Models, Biological; Renal Insufficiency, Chronic; Uric Acid; Xanthine; Xanthine Oxidase | 2016 |
Allopurinol decreases serum uric acid level and intestinal glucose transporter-5 expression in rats with fructose-induced hyperuricemia.
Topics: Allopurinol; Animals; Benzbromarone; Fructose; Glucose Transporter Type 2; Glucose Transporter Type 5; Hyperuricemia; Intestinal Mucosa; Liver; Male; Rats; Uric Acid; Xanthine Oxidase | 2016 |
A joint effort over a period of time: factors affecting use of urate-lowering therapy for long-term treatment of gout.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Cooperative Behavior; Female; Gout; Gout Suppressants; Health Knowledge, Attitudes, Practice; Humans; Long-Term Care; Male; Medication Adherence; Middle Aged; Motivation; Physician-Patient Relations; Practice Guidelines as Topic; Qualitative Research; Rheumatologists; United Kingdom; Uric Acid | 2016 |
The Budget Impact of Increased Use of Febuxostat in the Management of Gout: A US Health Plan Managed Care Pharmacy and Medical Costs Perspective.
Topics: Adult; Aged; Allopurinol; Budgets; Chronic Disease; Febuxostat; Female; Gout; Gout Suppressants; Health Care Costs; Humans; Male; Managed Care Programs; Middle Aged; Pharmaceutical Services; Renal Insufficiency, Chronic; United States; Uric Acid; Young Adult | 2016 |
Febuxostat for Patients With Gout and Severe Chronic Kidney Disease: Which Is the Appropriate Dosage? Comment on the Article by Saag et al.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Renal Insufficiency, Chronic; Thiazoles; Uric Acid | 2016 |
Allopurinol Dose Reductions Based on Creatinine Alert Redesign System.
Topics: Allopurinol; Creatinine; Gout; Gout Suppressants; Humans; Uric Acid | 2016 |
Hypouricemic effect of allopurinol are improved by Pallidifloside D based on the uric acid metabolism enzymes PRPS, HGPRT and PRPPAT.
Topics: Allopurinol; Animals; Drug Synergism; Gene Expression Regulation; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Male; Mice; PC12 Cells; Rats; Ribose-Phosphate Pyrophosphokinase; RNA, Messenger; Saponins; Smilax; Transaminases; Uric Acid; Xanthine Oxidase | 2016 |
The safety and efficacy of benzbromarone in gout in Aotearoa New Zealand.
Topics: Aged; Allopurinol; Benzbromarone; Comorbidity; Exanthema; Female; Gout; Gout Suppressants; Humans; Kidney Function Tests; Liver Function Tests; Male; Middle Aged; New Zealand; Retrospective Studies; Uric Acid; Uricosuric Agents | 2016 |
A new sensitive and quantitative chemiluminescent assay to monitor intracellular xanthine oxidase activity for rapid screening of inhibitors in living endothelial cells.
Topics: Allopurinol; Biological Assay; Cytoplasm; Enzyme Inhibitors; Human Umbilical Vein Endothelial Cells; Humans; Kinetics; Limit of Detection; Luminescent Measurements; Luminol; Oxidation-Reduction; Oxypurinol; Uric Acid; Xanthine Oxidase | 2016 |
Uric acid lowering effect of Tibetan Medicine RuPeng15 powder in animal models of hyperuricemia.
Topics: Animals; Drugs, Chinese Herbal; Humans; Hyperuricemia; Liver; Male; Medicine, Tibetan Traditional; Rats; Uric Acid; Xanthine Oxidase | 2016 |
Tophaceous Gout in an Anorectic Patient Visualized by Dual Energy Computed Tomography (DECT).
Topics: Absorptiometry, Photon; Allopurinol; Anorexia Nervosa; Biomarkers; Biopsy; Colchicine; Drug Therapy, Combination; Febuxostat; Female; Gout; Gout Suppressants; Humans; Middle Aged; Patient Compliance; Predictive Value of Tests; Sensitivity and Specificity; Urate Oxidase; Uric Acid | 2016 |
Uricase Inhibits Nitrogen Dioxide-Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism.
Topics: Adaptive Immunity; Allergens; Allopurinol; Animals; Antigen Presentation; Asthma; Cytokines; Disease Models, Animal; Humans; Hypersensitivity; Lung; Mice; Mice, Inbred BALB C; Nitrogen Dioxide; Ovalbumin; Serum Albumin; Th2 Cells; Urate Oxidase; Uric Acid | 2016 |
Poorly controlled gout: who is doing poorly?
Topics: Allopurinol; Arthritis; Comorbidity; Gout; Humans; Hyperuricemia; Inflammation; Medication Adherence; Patient Education as Topic; Primary Health Care; Professional-Patient Relations; Rheumatology; Singapore; Uric Acid | 2016 |
Renal dosing of allopurinol results in suboptimal gout care.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Kidney; Uric Acid | 2017 |
Xanthine oxidase gene variants and their association with blood pressure and incident hypertension: a population study.
Topics: Adult; Arterial Pressure; Belgium; Blood Pressure; Czech Republic; Diastole; Female; Follow-Up Studies; Genotype; Heterozygote; Humans; Hypertension; Incidence; Italy; Male; Middle Aged; Poland; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prospective Studies; Russia; Uric Acid; White People; Xanthine Oxidase; Young Adult | 2016 |
Inhibitory effect of verbascoside on xanthine oxidase activity.
Topics: Animals; Enzyme Inhibitors; Glucosides; Hyperuricemia; Liver; Male; Molecular Docking Simulation; Phenols; Protein Structure, Secondary; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2016 |
[Analysis of the 2015 British guidelines on the prevention and management of tumor lysis syndrome].
Topics: Adult; Allopurinol; Child; Hematologic Neoplasms; Humans; Incidence; Neoplasms; Practice Guidelines as Topic; Risk Factors; Tumor Lysis Syndrome; United Kingdom; Uric Acid | 2017 |
Effects of extracts from Corylopsis coreana Uyeki (Hamamelidaceae) flos on xanthine oxidase activity and hyperuricemia.
Topics: Animals; Biomarkers; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Flowers; Gout Suppressants; Hamamelidaceae; Hyperuricemia; Liver; Male; Mice, Inbred ICR; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Plants, Medicinal; Solvents; Uric Acid; Xanthine Oxidase | 2016 |
Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo.
Topics: Animals; Humans; Hyperuricemia; Lamiaceae; Liver; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Streptozocin; THP-1 Cells; Uric Acid; Xanthine Oxidase | 2016 |
The management of gout in different clinical specialties in Turkey: a patient-based survey.
Topics: Adult; Aged; Allopurinol; Colchicine; Female; Gout; Gout Suppressants; Humans; Internal Medicine; Life Style; Male; Middle Aged; Orthopedics; Patient Admission; Physical Therapy Specialty; Primary Health Care; Rheumatology; Surveys and Questionnaires; Turkey; Uric Acid | 2016 |
Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose.
Topics: Acute Disease; Aged; Allopurinol; Cohort Studies; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Uric Acid; Xanthine Oxidase | 2017 |
Response: Renal dosing of allopurinol results in suboptimal gout care by T Neogi et al.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Kidney; Uric Acid | 2017 |
Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study.
Topics: Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Europe; Female; Heart Rate; Humans; Male; Statistics as Topic; Thioglycolates; Triazoles; Uric Acid; Xanthine Oxidase | 2016 |
Monitoring of Urate-Lowering Therapy Among US Veterans Following the 2012 American College of Rheumatology Guidelines for Management of Gout.
Topics: Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Drug Monitoring; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Retrospective Studies; Rheumatology; Tennessee; Uric Acid; Veterans; Xanthine Oxidase | 2017 |
Urat1-Uox double knockout mice are experimental animal models of renal hypouricemia and exercise-induced acute kidney injury.
Topics: Acute Kidney Injury; Allopurinol; Animals; Creatinine; Disease Models, Animal; Gout Suppressants; Male; Mice, Knockout; Organic Anion Transporters; Physical Conditioning, Animal; Renal Tubular Transport, Inborn Errors; Urate Oxidase; Uric Acid; Urinary Calculi | 2016 |
The cost-effectiveness of HLA-B*5801 screening to guide initial urate-lowering therapy for gout in the United States.
Topics: Allopurinol; Asian; Black or African American; Cost-Benefit Analysis; Female; Genetic Markers; Genetic Testing; Gout; Gout Suppressants; HLA-B51 Antigen; Humans; Male; Risk Factors; Sensitivity and Specificity; Stevens-Johnson Syndrome; United States; Uric Acid | 2017 |
A study comparing the safety and efficacy of febuxostat, allopurinol, and benzbromarone in Chinese gout patients: a retrospective cohort study
.
Topics: Adult; Allopurinol; Asian People; Benzbromarone; Biomarkers; China; Drug Dosage Calculations; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Remission Induction; Retrospective Studies; Time Factors; Treatment Outcome; Uric Acid | 2017 |
(E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1.
Topics: Animals; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Hyperuricemia; Male; Mice; Organic Anion Transporters; Oximes; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2017 |
A Clinical and Economic Comparison of Rasburicase and Allopurinol in the Treatment of Patients With Clinical or Laboratory Tumor Lysis Syndrome.
Topics: Allopurinol; Female; Gout Suppressants; Hospitalization; Humans; Hyperuricemia; Length of Stay; Male; Middle Aged; Retrospective Studies; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2017 |
Xanthine Oxidase Activity in Type 2 Diabetes Mellitus Patients with and without Diabetic Peripheral Neuropathy.
Topics: Aged; Biomarkers; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypertension; Logistic Models; Male; Middle Aged; Multivariate Analysis; Serum Albumin; Serum Albumin, Human; Sulfhydryl Compounds; Time Factors; Uric Acid; Xanthine Oxidase | 2016 |
The Effect of Allopurinol on Renal Function.
Topics: Aged; Allopurinol; Antimetabolites; Creatinine; Glomerular Filtration Rate; Humans; Hyperuricemia; Male; Middle Aged; New York City; Protective Agents; Renal Insufficiency, Chronic; Retrospective Studies; Treatment Outcome; Uric Acid; Veterans Health | 2017 |
Plasma oxypurinol as a measure of adherence in clinical trials.
Topics: Adult; Allopurinol; Clinical Trials as Topic; Female; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Middle Aged; Oxypurinol; Uric Acid | 2018 |
Oral delivery of allopurinol niosomes in treatment of gout in animal model.
Topics: Administration, Oral; Allopurinol; Animals; Disease Models, Animal; Drug Delivery Systems; Gout; Hexoses; Liposomes; Particle Size; Polysorbates; Rabbits; Surface Properties; Uric Acid | 2017 |
Xanthine Oxidase Induces Foam Cell Formation through LOX-1 and NLRP3 Activation.
Topics: CD36 Antigens; Cell Line, Tumor; Cell Transdifferentiation; Foam Cells; Humans; Inflammasomes; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; RNA Interference; Scavenger Receptors, Class A; Scavenger Receptors, Class E; Signal Transduction; Transfection; Uric Acid; Xanthine Oxidase | 2017 |
Effect of Rhizoma Polygoni Cuspidati and Ramulus Cinnamomi compatibility on uric acid metabolism and urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in rats with hyperuricemia.
Topics: Animals; Blood Urea Nitrogen; Cell Adhesion Molecules; Creatinine; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Kidney Diseases; Lipocalin-2; Male; Rats, Sprague-Dawley; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2017 |
2-Benzamido-4-methylthiazole-5-carboxylic Acid Derivatives as Potential Xanthine Oxidase Inhibitors and Free Radical Scavengers.
Topics: Animals; Benzamides; Computer Simulation; Drug Design; Enzyme Inhibitors; Free Radical Scavengers; Gout Suppressants; Molecular Docking Simulation; Rats; Structure-Activity Relationship; Thiazoles; Uric Acid; Xanthine Oxidase | 2017 |
Achieving serum urate targets in gout: an audit in a gout-oriented rheumatology practice.
Topics: Aged; Allopurinol; Biomarkers; Drug Substitution; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Medical Audit; Medication Adherence; Practice Guidelines as Topic; Probenecid; Retrospective Studies; Rheumatology; Time Factors; Treatment Outcome; Uric Acid | 2017 |
Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis).
Topics: Acute Disease; Allopurinol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Humans; Hyperuricemia; Injections, Intraperitoneal; Liver; Oxonic Acid; RNA, Messenger; Tupaia; Urate Oxidase; Uric Acid; Xanthine Dehydrogenase | 2017 |
Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.
Topics: Animals; Curcumin; Enzyme Inhibitors; HEK293 Cells; Humans; Hyperuricemia; Male; Mice; Models, Molecular; Organic Anion Transporters; Organic Cation Transport Proteins; Uric Acid; Xanthine Oxidase | 2017 |
Associations of plasma uric acid and purine metabolites with blood pressure in children: the KOALA Birth Cohort Study.
Topics: Blood Pressure; Child; Cohort Studies; Cross-Sectional Studies; Diastole; Female; Humans; Hypertension; Hypoxanthine; Male; Purines; Systole; Uric Acid; Xanthine; Xanthine Oxidase | 2017 |
Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Carrageenan; Disease Models, Animal; Hyperuricemia; Liver; Male; Phenols; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Uric Acid; Vietnam; Xanthine Oxidase | 2017 |
Effects of Gnaphalium affine D. Don on hyperuricemia and acute gouty arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Chromatography, High Pressure Liquid; Disease Models, Animal; Edema; Gnaphalium; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Oxonic Acid; Plant Extracts; Tandem Mass Spectrometry; Uric Acid; Xanthine Oxidase | 2017 |
GOSPEL 3: Management of gout by primary-care physicians and office-based rheumatologists in France in the early 21st century - comparison with 2006 EULAR Recommendations.
Topics: Allopurinol; Ambulatory Care; Colchicine; Female; France; Gout; Gout Suppressants; Health Behavior; History, 21st Century; Humans; Male; Patient Education as Topic; Practice Guidelines as Topic; Practice Patterns, Physicians'; Primary Health Care; Professional Practice; Prospective Studies; Rheumatology; Risk Factors; Risk Reduction Behavior; Uric Acid | 2017 |
Management of Gout and Hyperuricemia in CKD.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Diet Therapy; Disease Management; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Renal Dialysis; Renal Insufficiency, Chronic; Symptom Flare Up; Treatment Outcome; Uric Acid | 2017 |
Previous Dosage of Allopurinol Is a Strong Determinant of Febuxostat Efficacy.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Febuxostat; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Uric Acid | 2017 |
Qi-Zhu-Xie-Zhuo-Fang reduces serum uric acid levels and ameliorates renal fibrosis in hyperuricemic nephropathy rats.
Topics: Animals; Collagen; Disease Progression; Down-Regulation; Drugs, Chinese Herbal; Extracellular Matrix; Fibrosis; Hyperuricemia; Kidney; Kidney Diseases; Kidney Tubules; Male; Neuroprotective Agents; Phenotype; Rats, Wistar; Transcription Factors; Uric Acid; Xanthine Oxidase | 2017 |
Identification of the biologically active constituents of Camellia japonica leaf and anti-hyperuricemic effect in vitro and in vivo.
Topics: Animals; Antioxidants; Camellia; Enzyme Inhibitors; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Phenols; Plant Extracts; Plant Leaves; Uric Acid; Xanthine Oxidase | 2017 |
Negative correlation between serum uric acid and kidney URAT1 mRNA expression caused by resveratrol in rats.
Topics: Alanine Transaminase; Allopurinol; Animals; Anion Transport Proteins; Aspartate Aminotransferases; C-Reactive Protein; Creatinine; Cytokines; Disease Models, Animal; Hyperuricemia; Kidney; Male; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Messenger; Stilbenes; Uric Acid | 2017 |
Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia.
Topics: Animals; Camphanes; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme Inhibitors; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Panax notoginseng; Phytotherapy; Plant Components, Aerial; Plant Roots; Salvia miltiorrhiza; Uric Acid; Xanthine Oxidase | 2017 |
The Economic Value of Genetic Testing for Tolerance of Allopurinol in Gout.
Topics: Allopurinol; Genetic Testing; Gout; Gout Suppressants; Humans; Uric Acid | 2017 |
Hypouricemic and nephroprotective effects of total flavonoids from the residue of supercritical CO2 extraction of Humulus lupulus in potassium oxonate-induced mice.
Topics: Animals; Carbon Dioxide; Chromatography, Supercritical Fluid; Flavonoids; Humulus; Hyperuricemia; Inhibitory Concentration 50; Kidney; Male; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2017 |
Synthesis and evaluation of hydroxychalcones as multifunctional non-purine xanthine oxidase inhibitors for the treatment of hyperuricemia.
Topics: Animals; Antioxidants; Chalcones; Enzyme Inhibitors; Humans; Hyperuricemia; Mice; Models, Molecular; Uric Acid; Xanthine Oxidase | 2017 |
Effects of topiroxostat in hyperuricemic patients with chronic kidney disease.
Topics: Aged; Biomarkers; Blood Pressure; Enzyme Inhibitors; Female; Humans; Hypertension; Hyperuricemia; Incidence; Japan; Kidney; Male; Middle Aged; Nitriles; Proteinuria; Pyridines; Renal Insufficiency, Chronic; Retrospective Studies; Time Factors; Treatment Outcome; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2018 |
Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice.
Topics: Allopurinol; Animals; Diet, Western; Inflammation; Male; Mice; Mice, Inbred C57BL; Proteinuria; Uric Acid; Vascular Stiffness; Xanthine Oxidase | 2017 |
Involvement of xanthine oxidase activity with oxidative and inflammatory renal damage in silver catfish experimentally infected with Streptococcus agalactiae: Interplay with reactive oxygen species and nitric oxide.
Topics: Animals; Brazil; Catfishes; Disease Models, Animal; Fisheries; Fresh Water; Kidney; Kidney Tubules; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Purines; Reactive Oxygen Species; Streptococcal Infections; Streptococcus agalactiae; Uric Acid; Xanthine Oxidase | 2017 |
Allopurinol Medication Adherence as a Mediator of Optimal Outcomes in Gout Management.
Topics: Aged; Allopurinol; Clinical Pharmacy Information Systems; Disease Management; Dose-Response Relationship, Drug; Drug Monitoring; Female; Gout; Gout Suppressants; Humans; Longitudinal Studies; Male; Medication Adherence; Middle Aged; Patient Outcome Assessment; Surveys and Questionnaires; United States; Uric Acid | 2017 |
Prescription pattern of urate-lowering therapy in Korean gout patients: data from the national health claims database.
Topics: Allopurinol; Benzbromarone; Databases, Factual; Febuxostat; Gout; Gout Suppressants; Humans; Republic of Korea; Uric Acid | 2018 |
Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout.
Topics: Computer Simulation; Drug Therapy, Combination; Febuxostat; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Models, Biological; Risk Assessment; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase | 2018 |
Evaluating the urate-lowering effects of different microbial fermented extracts in hyperuricemic models accompanied with a safety study.
Topics: Animals; Fermentation; Gout; Gout Suppressants; Hyperuricemia; Mice; Uric Acid; Xanthine Oxidase | 2017 |
Uric acid contributes greatly to hepatic antioxidant capacity besides protein.
Topics: Allantoin; Allopurinol; Animals; Antioxidants; Enzyme Inhibitors; Liver; Mice, Inbred ICR; Oxidative Stress; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 2017 |
Febuxostat as a Prophylaxis for Tumor Lysis Syndrome in Children with Hematological Malignancies.
Topics: Adolescent; Age Factors; Allopurinol; Antineoplastic Agents; Biomarkers; Child; Child, Preschool; Creatinine; Down-Regulation; Enzyme Inhibitors; Febuxostat; Female; Hematologic Neoplasms; Humans; Induction Chemotherapy; Japan; Male; Retrospective Studies; Risk Factors; Treatment Outcome; Tumor Lysis Syndrome; Uric Acid; Xanthine Oxidase | 2017 |
Moderation of hyperuricemia in rats via consuming walnut protein hydrolysate diet and identification of new antihyperuricemic peptides.
Topics: Animals; Humans; Hyperuricemia; Juglans; Male; Nuts; Peptides; Plant Proteins; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2018 |
Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae.
Topics: Aeromonas caviae; Animals; Catfishes; Fish Diseases; Gram-Negative Bacterial Infections; Inflammation; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Spleen; Uric Acid; Xanthine Oxidase | 2017 |
Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics.
Topics: Allopurinol; Animals; Biomarkers; Drugs, Chinese Herbal; Fermentation; Hyperuricemia; Male; Metabolome; Metabolomics; Mice; Tea; Uric Acid; Weight Gain | 2017 |
Evaluation of the Effectiveness of Xanthine Oxidoreductase Inhibitors on Haemodialysis Patients using a Marginal Structural Model.
Topics: Aged; Allopurinol; Cardiovascular Diseases; Enzyme Inhibitors; Febuxostat; Female; Gout Suppressants; Humans; Incidence; Kidney Failure, Chronic; Male; Models, Structural; Prognosis; Renal Dialysis; Risk Factors; Survival Rate; Uric Acid; Xanthine Dehydrogenase | 2017 |
Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice.
Topics: Animals; Chalcones; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperuricemia; Hypoxanthine; Liver; Male; Mice, Inbred Strains; Purines; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2018 |
Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.
Topics: Animals; Bile Acids and Salts; Circadian Rhythm; Hepatocytes; Liver; Male; Mice; Mice, Inbred ICR; Orphan Nuclear Receptors; PPAR alpha; Purines; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2017 |
Lesinurad/allopurinol (Duzallo) for gout-associated hyperuricemia.
Topics: Allopurinol; Biomarkers; Drug Combinations; Gout; Gout Suppressants; Humans; Hyperuricemia; Thioglycolates; Treatment Outcome; Uric Acid; Uricosuric Agents | 2017 |
Presence of monosodium urate crystal deposition by dual-energy CT in patients with gout treated with allopurinol.
Topics: Adult; Aged; Allopurinol; Arthritis, Gouty; Female; Gout Suppressants; Humans; Male; Middle Aged; New Zealand; Prevalence; Prospective Studies; Severity of Illness Index; Tomography, X-Ray Computed; United States; Uric Acid | 2018 |
Comparative effectiveness of allopurinol, febuxostat and benzbromarone on renal function in chronic kidney disease patients with hyperuricemia: a 13-year inception cohort study.
Topics: Aged; Allopurinol; Benzbromarone; Cohort Studies; Disease Progression; Drug Monitoring; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Incidence; Male; Middle Aged; Renal Insufficiency, Chronic; Taiwan; Uric Acid; Uricosuric Agents | 2018 |
50 Years Ago in The Journal of Pediatrics: Prevention and Management of Acute Hyperuricemia in Childhood Leukemia.
Topics: Acute Disease; Allopurinol; Child; DNA, Neoplasm; History, 20th Century; Humans; Hyperuricemia; Mercaptopurine; Pediatrics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Lysis Syndrome; Uric Acid | 2017 |
Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2.
Topics: Aged; Albuminuria; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 2018 |
Efficacy and Safety of Febuxostat in Kidney Transplant Patients.
Topics: Adult; Aged; Biomarkers; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Kidney Transplantation; Male; Medical Records; Middle Aged; Retrospective Studies; Risk Factors; Seoul; Treatment Outcome; Uric Acid; Xanthine Oxidase; Young Adult | 2018 |
Weicao capsule ameliorates renal injury through increasing autophagy and NLRP3 degradation in UAN rats.
Topics: Allopurinol; Animals; Autophagy; Cell Line; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Kidney; Kidney Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Proteolysis; Rats; Rats, Sprague-Dawley; Uric Acid | 2018 |
The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; Decision Support Techniques; Diuretics; Drug Interactions; Female; Genotype; Gout Suppressants; Humans; Male; Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Uric Acid; Young Adult | 2018 |
A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice.
Topics: Allopurinol; Animals; Antibodies, Monoclonal; Antibody Affinity; Antioxidants; Creatinine; Cross Reactions; Female; Immune Sera; Immunization; Immunoglobulin G; Inflammation; Kidney; Liver; Malondialdehyde; Mice; Mice, Inbred BALB C; Oxonic Acid; Protective Agents; Spleen; Superoxide Dismutase; Th1 Cells; Th2 Cells; Urea; Uric Acid; Xanthine Oxidase | 2018 |
Mechanistic insights into the inhibition of quercetin on xanthine oxidase.
Topics: Enzyme Inhibitors; Humans; Hydrogen Peroxide; Molecular Docking Simulation; Oxidative Stress; Oxidoreductases; Quercetin; Uric Acid; Xanthine Oxidase | 2018 |
Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Cholesterol; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Exercise; Female; Glycated Hemoglobin; Humans; Incidence; Insulin; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Sex Factors; Triglycerides; Uric Acid; Xanthine Oxidase | 2018 |
Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats.
Topics: Allopurinol; Animals; Anticonvulsants; Brain; Cyclooxygenase Inhibitors; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Male; Rats, Wistar; Uric Acid | 2018 |
Body mass index is independently associated with xanthine oxidase activity in overweight/obese population.
Topics: Adult; Aged; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Inflammation; Male; Middle Aged; Obesity; Overweight; Uric Acid; Xanthine Oxidase | 2020 |
Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout.
Topics: Amines; Animals; Benzoin; Benzoxazoles; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gout; Gout Suppressants; HEK293 Cells; Humans; Immunity, Innate; Liver; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oximes; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2018 |
Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics.
Topics: Allopurinol; Clinical Trials as Topic; Febuxostat; Humans; Hyperuricemia; Models, Theoretical; Precision Medicine; Thioglycolates; Triazoles; Uric Acid; Uricosuric Agents | 2018 |
Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models.
Topics: Animals; Arthritis, Gouty; Disease Models, Animal; Drugs, Chinese Herbal; Edema; Glucose Transport Proteins, Facilitative; Glucosides; Gnaphalium; Hyperuricemia; Interleukin-1beta; Kidney; Luteolin; Male; Mice, Inbred ICR; Organic Anion Transporters; Uric Acid; Xanthine Oxidase | 2018 |
Hypouricemia and hyperuricosuria in a pubescent girl: Answers.
Topics: Acute Kidney Injury; Allopurinol; Antioxidants; Child; Cystinosis; Diagnosis, Differential; Fanconi Syndrome; Female; Genetic Testing; Glucose Transport Proteins, Facilitative; Humans; Inappropriate ADH Syndrome; Kidney Tubules; Organic Anion Transporters; Organic Cation Transport Proteins; Renal Reabsorption; Renal Tubular Transport, Inborn Errors; Uric Acid; Urinary Calculi | 2018 |
Uric Acid Induces Cardiomyocyte Apoptosis via Activation of Calpain-1 and Endoplasmic Reticulum Stress.
Topics: Allopurinol; Animals; Apoptosis; Calpain; Cell Line; Endoplasmic Reticulum Stress; Hyperuricemia; Male; Microscopy, Confocal; Myocardium; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Uric Acid | 2018 |
Chronic Disease Approaches Needed to Curb Gout's Growing Burden.
Topics: Allopurinol; Chronic Disease; Diet; Drug Combinations; Febuxostat; Gout; Gout Suppressants; Healthy Lifestyle; Humans; Patient Education as Topic; Practice Guidelines as Topic; Purines; Thioglycolates; Triazoles; Uric Acid | 2018 |
Reply to: Serum uric acid levels positively correlates with 10-year cardiovascular risk score in the general population from China.
Topics: Cardiovascular Diseases; China; Humans; Hyperuricemia; Risk Factors; Uric Acid; Xanthine Oxidase | 2018 |
Improvement in OMERACT domains and renal function with regular treatment for gout: a 12-month follow-up cohort study.
Topics: Adult; Allopurinol; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Kidney; Male; Mexico; Middle Aged; Time Factors; Treatment Outcome; Uric Acid | 2018 |
Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.
Topics: Animals; Armillaria; Down-Regulation; Ethanol; Gastrointestinal Tract; Gene Expression; Glucose Transport Proteins, Facilitative; Hydrogen Bonding; Hyperuricemia; Male; Membrane Transport Proteins; Mice; Organic Anion Transport Protein 1; Phytotherapy; Plant Extracts; Uric Acid; Water; Xanthine Oxidase | 2018 |
4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzene Derivatives; Enzyme Inhibitors; Gout; Humans; Hyperuricemia; Inflammasomes; Liver; Male; Mice; Mice, Inbred NOD; Molecular Docking Simulation; NLR Family, Pyrin Domain-Containing 3 Protein; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2018 |
Experimental heat stress nephropathy and liver injury are improved by allopurinol.
Topics: Allopurinol; Animals; Collagen; Disease Models, Animal; Enzyme Inhibitors; Heat Stress Disorders; Hot Temperature; HSP70 Heat-Shock Proteins; Hyperthermia, Induced; Kidney; Kidney Diseases; Liver; Liver Diseases; Male; Mice, Inbred C57BL; Uric Acid; Xanthine Oxidase | 2018 |
The impact of serum uric acid reduction on renal function and blood pressure in chronic kidney disease patients with hyperuricemia.
Topics: Adult; Aged; Allopurinol; Blood Pressure; Febuxostat; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies; Uric Acid | 2018 |
Surprising safety outcomes of urate-lowering therapy.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Uric Acid | 2018 |
Hereditary xanthinuria is not so rare disorder of purine metabolism.
Topics: Adult; Aldehyde Oxidase; Allopurinol; Child; Child, Preschool; Czech Republic; Diagnosis, Differential; Humans; Metabolism, Inborn Errors; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Renal Tubular Transport, Inborn Errors; Uric Acid; Urinary Calculi; Xanthine; Xanthine Dehydrogenase | 2018 |
Effectiveness of febuxostat in patients with allopurinol-refractory hyperuricemic chronic kidney disease
.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Biomarkers; Down-Regulation; Drug Resistance; Drug Substitution; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Odds Ratio; Renal Insufficiency, Chronic; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; Uric Acid; Young Adult | 2018 |
Pharmacophore modeling, molecular docking and molecular dynamics studies on natural products database to discover novel skeleton as non-purine xanthine oxidase inhibitors.
Topics: Biological Products; Enzyme Inhibitors; Gout; Humans; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Uric Acid; Xanthine Oxidase | 2018 |
Evaluation of a pharmacokinetic-pharmacodynamic model for hypouricaemic effects of febuxostat using datasets obtained from real-world patients.
Topics: Adult; Aged; Body Weight; Comorbidity; Datasets as Topic; Diabetes Mellitus; Dose-Response Relationship, Drug; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Models, Biological; Sodium Potassium Chloride Symporter Inhibitors; Treatment Outcome; Uric Acid; Xanthine Oxidase | 2018 |
GLUT9 influences uric acid concentration in patients with Lesch-Nyhan disease.
Topics: Adolescent; Adult; Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biomarkers; Child; Child, Preschool; Genetic Predisposition to Disease; Glucose Transport Proteins, Facilitative; Gout; Gout Suppressants; Humans; Hyperuricemia; Lesch-Nyhan Syndrome; Middle Aged; Neoplasm Proteins; Organic Anion Transporters; Organic Cation Transport Proteins; Phenotype; Polymorphism, Single Nucleotide; Renal Elimination; Treatment Outcome; Uric Acid; Young Adult | 2018 |
Medication adherence among gout patients initiated allopurinol: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD).
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Biomarkers; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Middle Aged; Retrospective Studies; Treatment Outcome; Uric Acid | 2018 |
Compounds containing trace element copper or zinc exhibit as potent hyperuricemia inhibitors via xanthine oxidase inactivation.
Topics: Animals; Copper; Coumaric Acids; Enzyme Inhibitors; Hyperuricemia; Male; Mice; Trace Elements; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Zinc | 2018 |
Heat stress nephropathy and hyperuricemia.
Topics: Allopurinol; Heat-Shock Response; Humans; Hyperuricemia; Liver; Uric Acid | 2018 |
Thiopurine-induced toxicity is associated with dysfunction variant of the human molybdenum cofactor sulfurase gene (xanthinuria type II).
Topics: Adult; Aldehyde Oxidase; Female; Humans; Mercaptopurine; Methyltransferases; Polymorphism, Genetic; Purine-Pyrimidine Metabolism, Inborn Errors; Sulfurtransferases; Uric Acid; Xanthine; Xanthine Dehydrogenase; Xanthine Oxidase | 2018 |
Effect of Uric Acid Control on Serum Creatinine.
Topics: Aged; Allopurinol; Antimetabolites; Comorbidity; Correlation of Data; Creatinine; Disease Progression; Female; Humans; Hyperuricemia; Kidney Failure, Chronic; Kidney Function Tests; Male; Metabolic Syndrome; Outcome Assessment, Health Care; Prevalence; United States; Uric Acid | 2019 |
Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aldosterone; Animals; Contraceptives, Oral, Combined; Corticosterone; Disease Models, Animal; Estrogens; Female; Glucose; Humans; Hypertension; Liver; Progestins; Rats; Rats, Wistar; Triglycerides; Uric Acid; Valproic Acid; Xanthine Oxidase | 2018 |
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Enzyme Inhibitors; Female; Gout; Gout Suppressants; Humans; Kidney Diseases; Male; Middle Aged; Randomized Controlled Trials as Topic; Thioglycolates; Treatment Outcome; Triazoles; Uric Acid; Xanthine Oxidase; Young Adult | 2019 |
Urate-Lowering Therapy in Moderate to Severe Chronic Kidney Disease.
Topics: Aged; Allopurinol; Cohort Studies; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Probenecid; Renal Insufficiency, Chronic; Retrospective Studies; Risk Factors; Severity of Illness Index; Uric Acid; Uricosuric Agents | 2018 |
Layer-by-layer electrochemical biosensors configuring xanthine oxidase and carbon nanotubes/graphene complexes for hypoxanthine and uric acid in human serum solutions.
Topics: Biosensing Techniques; Blood Chemical Analysis; Electrodes; Graphite; Humans; Hypoxanthine; Nanotubes, Carbon; Uric Acid; Xanthine Oxidase | 2018 |
Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities.
Topics: Adenosine Deaminase; Androgen Receptor Antagonists; Animals; Animals, Newborn; Antioxidants; Female; Flutamide; Gestational Age; Glucose; Homeostasis; Insulin Resistance; Placenta; Pregnancy; Pregnancy Outcome; Rats, Wistar; Sodium Acetate; Testosterone; Uric Acid; Xanthine Oxidase | 2018 |
DKB114, A Mixture of
Topics: Animals; Chrysanthemum; Cinnamomum; Enzyme Inhibitors; Flowers; Gene Expression; Glucose Transport Proteins, Facilitative; HEK293 Cells; Hep G2 Cells; Humans; Hyperuricemia; Liver; Male; Membrane Potential, Mitochondrial; Oocytes; Organic Anion Transporters; Organic Cation Transport Proteins; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Transfection; Urate Oxidase; Uric Acid; Xanthine Oxidase | 2018 |
Sodium acetate improves disrupted glucoregulation and hepatic triglyceride content in insulin-resistant female rats: involvement of adenosine deaminase and dipeptidyl peptidase-4 activities.
Topics: Adenosine Deaminase; Animals; Dipeptidyl Peptidase 4; Drug Combinations; Ethinyl Estradiol; Female; Glucose; Insulin Resistance; Levonorgestrel; Liver; Rats, Wistar; Sodium Acetate; Triglycerides; Uric Acid; Xanthine Oxidase | 2019 |
Accumulation of uric acid in the epidermis forms the white integument of Samia ricini larvae.
Topics: Allopurinol; Animals; Color; DNA; Epidermis; Female; Gene Knockdown Techniques; Larva; Male; Microscopy, Electron, Transmission; Moths; Phylogeny; Sequence Analysis, DNA; Uric Acid; Xanthine; Xanthine Oxidase | 2018 |
Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice.
Topics: Animals; Creatinine; Disease Models, Animal; Fruit; Gene Expression Regulation; Hyperuricemia; Liver; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Phytochemicals; Phytotherapy; Plant Extracts; Rosaceae; Uric Acid; Xanthine Oxidase | 2018 |
Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate.
Topics: Acute Kidney Injury; Allopurinol; Animals; Disease Models, Animal; Disease Progression; Glycerol; Heat-Shock Response; Hot Temperature; Humans; Kidney; Male; Occupational Exposure; Oxidative Stress; Oxonic Acid; Rats; Renal Insufficiency, Chronic; Rhabdomyolysis; Sodium Bicarbonate; Treatment Outcome; Urate Oxidase; Uric Acid | 2018 |
Effect of fenofibrate on uric acid level in patients with gout.
Topics: Adult; Aged; Drug Interactions; Enzyme Inhibitors; Female; Fenofibrate; Gout; Humans; Kidney; Liver; Male; Middle Aged; Uric Acid; Xanthine Oxidase | 2018 |
Serum urate levels and therapy in adults treated with long-term dialysis: a retrospective cross-sectional study.
Topics: Aged; Allopurinol; Cohort Studies; Cross-Sectional Studies; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Renal Dialysis; Retrospective Studies; Treatment Outcome; Uric Acid | 2019 |
Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model.
Topics: Allopurinol; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Economics, Pharmaceutical; Febuxostat; Gout; Gout Suppressants; Health Care Costs; Humans; Medication Adherence; Models, Biological; Models, Economic; Quality of Life; Quality-Adjusted Life Years; Thioglycolates; Treatment Outcome; Triazoles; United Kingdom; Uric Acid | 2018 |
A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.
Topics: Allopurinol; Animals; Anserine; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Hyperuricemia; Larva; Oxonic Acid; Uric Acid; Xanthine; Zebrafish | 2019 |
New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats.
Topics: Animals; Humans; Hyperuricemia; Liver; Male; Oryza; Oxonic Acid; Peptides; Plant Extracts; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2019 |
Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia.
Topics: Animals; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Fibroblasts; Fibrosis; Histones; Hyperuricemia; Kidney Diseases; Mice; Mitogen-Activated Protein Kinase 3; Phosphorylation; RNA, Small Interfering; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Uric Acid; Xanthine Oxidase | 2019 |
Comparison of efficacy and safety between febuxostat and allopurinol in early post-renal transplant recipients with new onset of hyperuricemia.
Topics: Adolescent; Adult; Allopurinol; Cohort Studies; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kidney Transplantation; Male; Middle Aged; Retrospective Studies; Time Factors; Transplant Recipients; Treatment Outcome; Uric Acid; Young Adult | 2019 |
Comparison of renoprotective effects of febuxostat and allopurinol in hyperuricemic patients with chronic kidney disease.
Topics: Aged; Allopurinol; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kaplan-Meier Estimate; Male; Middle Aged; Progression-Free Survival; Proportional Hazards Models; Renal Insufficiency, Chronic; Retrospective Studies; Time Factors; Uric Acid | 2019 |
Associations between urate-lowering therapy and the risk of type 2 diabetes mellitus.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Allopurinol; Benzbromarone; Case-Control Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Prevalence; Proportional Hazards Models; Taiwan; Treatment Outcome; Uric Acid; Young Adult | 2019 |
Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Nutrition Surveys; Prevalence; Probenecid; United States; Uric Acid; Uricosuric Agents; Young Adult | 2019 |
Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.
Topics: Animals; Creatinine; Down-Regulation; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Humans; Hyperuricemia; Kidney; Male; Mice; Mice, Inbred ICR; Organic Anion Transporters; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2019 |
Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model.
Topics: Allopurinol; Animals; Creatinine; Gout Suppressants; Hyperuricemia; Inflammation; Kidney; Macrophages; Male; Mice; Nitric Oxide Synthase Type III; Uric Acid | 2018 |
Urate-lowering therapy alleviates atherosclerosis inflammatory response factors and neointimal lesions in a mouse model of induced carotid atherosclerosis.
Topics: Allopurinol; Animals; Antimetabolites; Carotid Artery Diseases; Human Umbilical Vein Endothelial Cells; Humans; Hyperuricemia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neointima; Reactive Oxygen Species; Urate Oxidase; Uric Acid | 2019 |
Hypouricemic and nephroprotective roles of anthocyanins in hyperuricemic mice.
Topics: Animals; Anthocyanins; Blood Urea Nitrogen; Creatinine; Diet; Hyperuricemia; Male; Mice; Mice, Inbred ICR; Random Allocation; Uric Acid; Xanthine Oxidase; Yeasts | 2019 |
Monosodium Urate Contributes to Retinal Inflammation and Progression of Diabetic Retinopathy.
Topics: Allopurinol; Animals; Benzbromarone; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; Hyperuricemia; Inflammation; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Retina; Risk Factors; Uric Acid; Vitreous Body; Xanthine Oxidase | 2019 |
Inhibiting PNP for the therapy of hyperuricemia in Lesch-Nyhan disease: Preliminary in vitro studies with analogues of immucillin-G.
Topics: Allopurinol; Cells, Cultured; Enzyme Inhibitors; Humans; Hyperuricemia; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Purine-Nucleoside Phosphorylase; Purines; Pyrimidinones; Pyrroles; Reproducibility of Results; Uric Acid; Xanthine | 2019 |
Medical dissolution therapy for the treatment of uric acid nephrolithiasis.
Topics: Adult; Aged; Allopurinol; Female; Humans; Kidney Calculi; Male; Middle Aged; Nephrolithiasis; Potassium Citrate; Retrospective Studies; Uric Acid | 2019 |
Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice.
Topics: Animals; Creatinine; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Male; Mice; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Protective Agents; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2019 |
Uric acid and xantine-oxidase inhibitors in patients with gout: A re-assessment and an update.
Topics: Aged; Allopurinol; Enzyme Inhibitors; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Uric Acid; Xanthine Oxidase | 2019 |
Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
Topics: Aged; Aged, 80 and over; Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cytokines; Ethnicity; Female; Genome-Wide Association Study; Glucose Transport Proteins, Facilitative; Humans; Male; Middle Aged; Neoplasm Proteins; Oxypurinol; Prognosis; Uric Acid | 2019 |
Hyperuricaemia and vascular risk: the debate continues.
Topics: Cardiovascular Diseases; Gout; Humans; Hyperuricemia; Risk Factors; Uric Acid; Xanthine Oxidase | 2019 |
The difficult relationship between uric acid and cardiovascular disease.
Topics: Aged; Allopurinol; Atrial Fibrillation; Cardiovascular Diseases; Febuxostat; Humans; Medicare; Risk Factors; United States; Uric Acid | 2019 |
Renal safety and urate-lowering efficacy of febuxostat in gout patients with stage 4-5 chronic kidney disease not yet on dialysis.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Renal Dialysis; Renal Insufficiency, Chronic; Republic of Korea; Treatment Outcome; Uric Acid | 2020 |
Novel xanthine oxidase-based cell model using HK-2 cell for screening antihyperuricemic functional compounds.
Topics: Cell Culture Techniques; Cell Line; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Hyperuricemia; Kidney Tubules; Uric Acid; Xanthine Oxidase | 2019 |
Integration of Pharmacometrics and Pharmacoeconomics to Quantify the Value of Improved Forgiveness to Nonadherence: A Case Study of Novel Xanthine Oxidase Inhibitors for Gout.
Topics: Allopurinol; Computer Simulation; Cost-Benefit Analysis; Costs and Cost Analysis; Drug Monitoring; Economics, Pharmaceutical; Febuxostat; Gout; Gout Suppressants; Humans; Insurance, Health, Reimbursement; Medication Adherence; Quality-Adjusted Life Years; Uric Acid; Xanthine Oxidase | 2019 |
Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition.
Topics: Animals; Enzyme Inhibitors; HEK293 Cells; Humans; Hyperuricemia; Kidney; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Uric Acid; Xanthenes; Xanthine Oxidase | 2019 |
Highly Acylated Anthocyanins from Purple Sweet Potato ( Ipomoea batatas L.) Alleviate Hyperuricemia and Kidney Inflammation in Hyperuricemic Mice: Possible Attenuation Effects on Allopurinol.
Topics: Acylation; Allopurinol; Animals; Anthocyanins; Disease Models, Animal; Enzyme Inhibitors; Humans; Hyperuricemia; Ipomoea batatas; Kidney; Male; Mice; Plant Extracts; Uric Acid | 2019 |
Hyperuricemia treatment in acute heart failure patients does not improve their long-term prognosis: A propensity score matched analysis from the AHEAD registry.
Topics: Acute Disease; Aged; Aged, 80 and over; Allopurinol; Biomarkers; Cause of Death; Czech Republic; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gout Suppressants; Heart Failure; Humans; Hyperuricemia; Male; Middle Aged; Prognosis; Propensity Score; Prospective Studies; Registries; Survival Rate; Time Factors; Treatment Outcome; Uric Acid | 2019 |
Low-Dose Allopurinol Promotes Greater Serum Urate Lowering in Gout Patients with Chronic Kidney Disease Compared with Normal Kidney Function.
Topics: Allopurinol; Dose-Response Relationship, Drug; Drug Monitoring; Female; Gout; Gout Suppressants; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; New York; Outcome and Process Assessment, Health Care; Patient Acuity; Renal Elimination; Renal Insufficiency, Chronic; Retrospective Studies; Uric Acid; Veterans Health Services | 2019 |
Comparative Study of Real-Life Management Strategies in Gout: Data From Two Protocolized Gout Clinics.
Topics: Aged; Allopurinol; Clinical Decision Rules; Clinical Protocols; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Logistic Models; Male; Middle Aged; Patient Satisfaction; Precision Medicine; Symptom Flare Up; Treatment Outcome; Uric Acid; Uricosuric Agents | 2020 |
Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.
Topics: Anacardiaceae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Chalcone; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Flavanones; Hyperuricemia; Inflammation; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oxonic Acid; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2019 |
Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.
Topics: Alpinia; Animals; China; Gout; Humans; Hyperuricemia; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters; Oxonic Acid; Plant Extracts; Rats; Republic of Korea; Uric Acid; Xanthine Oxidase | 2019 |
Glutamine confers renoprotection by normalizing lipid and glutathione content in insulin-resistant pregnant rats.
Topics: Adenosine Deaminase; Animals; Female; Fructose; Glutamine; Glutathione; Insulin Resistance; Lipids; Metabolic Syndrome; Neuroprotection; Pregnancy; Rats; Rats, Wistar; Uric Acid; Xanthine Oxidase | 2019 |
Lychnophora pinaster ethanolic extract and its chemical constituents ameliorate hyperuricemia and related inflammation.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Ethanol; Gout Suppressants; Hexanes; Hyperuricemia; Liver; Male; Mice; Phytochemicals; Plant Components, Aerial; Plant Extracts; Solvents; Uric Acid; Xanthine Oxidase | 2019 |
Switching from allopurinol to febuxostat: efficacy and safety in the treatment of hyperuricemia in renal transplant recipients.
Topics: Adult; Allografts; Allopurinol; Drug Substitution; Febuxostat; Female; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kidney; Kidney Transplantation; Male; Middle Aged; Transplant Recipients; Treatment Outcome; Uric Acid | 2019 |
Allopurinol and the risk of prostate cancer.
Topics: Adult; Aged; Allopurinol; Case-Control Studies; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Prostatic Neoplasms; Protective Factors; Risk Factors; Taiwan; Uric Acid | 2020 |
Efficacy of uric acid-lowering therapy on hypercholesterolemia and hypertriglyceridemia in gouty patients.
Topics: Adult; Allopurinol; Benzbromarone; Biomarkers; Cholesterol; Febuxostat; Female; Gout; Gout Suppressants; Humans; Hypercholesterolemia; Hypertriglyceridemia; Male; Middle Aged; Retrospective Studies; Time Factors; Treatment Outcome; Triglycerides; Uric Acid; Uricosuric Agents | 2019 |
Clinical characteristics and risk factors for gout flare during the postsurgical period.
Topics: Allopurinol; Blood Loss, Surgical; Female; Foot Joints; Gout; Gout Suppressants; Humans; Knee Joint; Male; Middle Aged; Operative Time; Postoperative Complications; Postoperative Period; Risk Factors; Symptom Flare Up; Uric Acid | 2019 |
Effects of Conventional Uric Acid-Lowering Therapy on Monosodium Urate Crystal Deposits.
Topics: Aged; Alcohol Drinking; Allopurinol; Benzbromarone; Diet Therapy; Febuxostat; Female; Foot Joints; Fructose; Gout; Gout Suppressants; Humans; Male; Meat; Middle Aged; Prospective Studies; Purines; Shellfish; Tomography, X-Ray Computed; Uric Acid; Uricosuric Agents | 2020 |
Radiologic evidence of symmetric and polyarticular monosodium urate crystal deposition in gout - A cluster pattern analysis of dual-energy CT.
Topics: Aged; Allopurinol; Female; Foot Joints; Gout; Gout Suppressants; Hand Joints; Humans; Knee Joint; Male; Middle Aged; Tomography, X-Ray Computed; Uric Acid | 2020 |
Excess Iron Enhances Purine Catabolism Through Activation of Xanthine Oxidase and Impairs Myelination in the Hippocampus of Nursing Piglets.
Topics: Animals; Disease Models, Animal; Enzyme Activation; Female; Gene Expression; Hippocampus; Humans; Infant; Iron Overload; Iron, Dietary; Lipid Peroxidation; Liver; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Myelin Basic Protein; Myelin Sheath; Oxidative Stress; Purines; RNA, Messenger; Sus scrofa; Uric Acid; Xanthine Oxidase | 2019 |
Management of patients with gout and achievement of target serum urate levels at a tertiary rheumatology service in Australia.
Topics: Allopurinol; Australia; Female; Gout; Gout Suppressants; Humans; Male; Rheumatology; Treatment Outcome; Uric Acid | 2020 |
Factors Influencing the Effectiveness of Allopurinol in Achieving and Sustaining Target Serum Urate in a US Veterans Affairs Gout Cohort.
Topics: Age Factors; Aged; Aged, 80 and over; Allopurinol; Comorbidity; Female; Follow-Up Studies; Gout; Gout Suppressants; Health Services Accessibility; Humans; Male; Middle Aged; Risk Factors; Severity of Illness Index; Treatment Outcome; United States; Uric Acid; Veterans | 2020 |
Antihyperuricemic and anti-gouty arthritis activities of
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Gouty; Carbon; Drugs, Chinese Herbal; Hyperuricemia; Inflammation; Male; Mice; Microscopy, Electron, Transmission; Plant Extracts; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Uric Acid; Xanthine Oxidase | 2019 |
Evaluation of Treatment Success Rate Among Antihyperuricemic Using Real-World Data.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Treatment Outcome; Uric Acid | 2019 |
The target uric acid level in multimorbid patients with gout is difficult to achieve: data from a longitudinal Swiss single-centre cohort.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Female; Gout; Gout Suppressants; Humans; Longitudinal Studies; Male; Middle Aged; Multimorbidity; Patient Acceptance of Health Care; Switzerland; Uric Acid; Young Adult | 2019 |
The challenges of managing gout in primary care: Results of a best-practice audit.
Topics: Aged; Allopurinol; Clinical Audit; Clinical Chemistry Tests; Clinical Protocols; Colchicine; Comorbidity; Diabetes Mellitus; Disease Management; Female; Gout; Gout Suppressants; Guideline Adherence; Humans; Hyperlipidemias; Hypertension; Hyperuricemia; Male; Mass Screening; Middle Aged; New Zealand; Obesity; Patient Education as Topic; Practice Guidelines as Topic; Primary Health Care; Referral and Consultation; Renal Insufficiency, Chronic; Rheumatology; Rural Population; Uric Acid | 2019 |
Impact of urate-lowering drugs on the progression and recovery from chronic kidney disease among gout patients.
Topics: Allopurinol; Benzbromarone; Disease Progression; Febuxostat; Female; Glomerular Filtration Rate; Gout; Gout Suppressants; Humans; Incidence; Male; Middle Aged; Recovery of Function; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid; Uricosuric Agents | 2019 |
Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Chemokine CCL2; Collagen; Diabetic Nephropathies; Febuxostat; Glucose Intolerance; Hyperglycemia; Hyperuricemia; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Kidney Glomerulus; Mice; Mice, Inbred C57BL; Mice, Obese; Oxidative Stress; Peptide Fragments; Uric Acid; Xanthine Oxidase | 2019 |
Uric acid induced the phenotype transition of vascular endothelial cells
Topics: Allopurinol; Animals; Cells, Cultured; Endothelium, Vascular; Glycocalyx; Gout Suppressants; Hyperuricemia; Kidney Diseases; Male; Oxidative Stress; Phenotype; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Uric Acid | 2019 |
Could uric acid reduction by specific xanthine oxidase inhibition improve vascular function and reduce cardiovascular risk?
Topics: Cardiovascular Diseases; Humans; Hypertension; Hyperuricemia; Nitriles; Pyridines; Risk Factors; Uric Acid; Xanthine Oxidase | 2019 |
Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors.
Topics: Animals; Benzamides; Cattle; Drug Design; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Niacinamide; Nitriles; Protein Binding; Pyridines; Structure-Activity Relationship; Tetrazoles; Uric Acid; Xanthine Oxidase | 2019 |
Role of allopurinol and febuxostat in the amelioration of dextran-induced colitis in rats.
Topics: Allopurinol; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Dextran Sulfate; Drug Therapy, Combination; Febuxostat; Glutathione; Interleukin-1beta; Interleukin-6; Male; Malondialdehyde; Rats, Wistar; Sulfasalazine; Superoxide Dismutase; Uric Acid; Xanthine Oxidase | 2020 |
Comparison of long-term efficacy and renal safety of febuxostat and allopurinol in patients with chronic kidney diseases
.
Topics: Adult; Allopurinol; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Renal Insufficiency, Chronic; Retrospective Studies; Treatment Outcome; Uric Acid | 2020 |
Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis.
Topics: Administration, Oral; Allopurinol; Animals; Chemical Precipitation; Chitosan; Disease Models, Animal; Drug Delivery Systems; Kidney; Magnetite Nanoparticles; Mice; Nanoparticles; Nephrolithiasis; Oxonic Acid; Uric Acid | 2019 |
Comprehensive analysis of mechanism underlying hypouricemic effect of glucosyl hesperidin.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Glucose Transport Proteins, Facilitative; Glucosides; Hesperidin; Hyperuricemia; Intestine, Small; Kidney; Liver; Male; Mice, Inbred C57BL; Organic Anion Transporters; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2020 |
Influence of hyperuricemia treatment on postoperative acute kidney injury among hyperuricemia patients: a single-center retrospective database analysis.
Topics: Acute Kidney Injury; Aged; Allopurinol; Creatinine; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Incidence; Kidney; Male; Middle Aged; Postoperative Complications; Postoperative Period; Retrospective Studies; Risk Factors; Uric Acid | 2019 |
Burden and management of gout in a multi-ethnic Asian cohort.
Topics: Adult; Aged; Allopurinol; Comorbidity; Cross-Sectional Studies; Diabetes Mellitus; Dyslipidemias; Emergency Service, Hospital; Ethnicity; Febuxostat; Female; Gout; Gout Suppressants; Hospitalization; Humans; Hypertension; Hyperuricemia; Male; Middle Aged; Probenecid; Renal Insufficiency, Chronic; Severity of Illness Index; Singapore; Treatment Outcome; Uric Acid | 2020 |
Chronic tophaceous gout presenting as nonhealing ulcers.
Topics: Adult; Allopurinol; Biopsy, Needle; Debridement; Foot Ulcer; Gout; Humans; Immunohistochemistry; India; Male; Pain Measurement; Risk Assessment; Severity of Illness Index; Treatment Outcome; Uric Acid; Wound Healing | 2019 |
Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice.
Topics: Animals; Creatinine; Hyperuricemia; Kidney; Liver; Male; Mice; Organic Anion Transporters; Orthosiphon; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2020 |
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout.
Topics: Animals; Benzimidazoles; Benzoxazoles; Cell Line; Disease Models, Animal; Gout; Humans; Hyperuricemia; Interleukin-1beta; Liver; Mice; Monocytes; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Rats; Structure-Activity Relationship; Synovial Membrane; Uric Acid; Xanthine Oxidase | 2020 |
Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.
Topics: Drug Design; Enzyme Inhibitors; Hyperuricemia; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Oxadiazoles; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2020 |
Uric acid increases IL-1β secretion and Caspase-1 activation in PBMCs of Behçet's disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol.
Topics: Adult; Allopurinol; Behcet Syndrome; Caspase 1; Cells, Cultured; Female; Humans; Immunologic Factors; Interleukin-1beta; Leukocytes, Mononuclear; Male; Middle Aged; Nitric Oxide; Uric Acid; Xanthine Oxidase; Young Adult | 2020 |
Comparative effectiveness of rasburicase versus allopurinol for cancer patients with renal dysfunction and hyperuricemia.
Topics: Adult; Allopurinol; Female; Humans; Hyperuricemia; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasms; Odds Ratio; Prognosis; Propensity Score; Renal Insufficiency; Retrospective Studies; Treatment Outcome; Tumor Lysis Syndrome; Urate Oxidase; Uric Acid | 2020 |
Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice.
Topics: Allopurinol; Animals; Diet, High-Fat; Disease Models, Animal; Fatty Liver; Febuxostat; Hyperuricemia; Insulin Resistance; Lipid Peroxidation; Liver; Macrophage Activation; Mice, Inbred C57BL; Molecular Targeted Therapy; Uric Acid; Xanthine Oxidase | 2020 |
Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.
Topics: Adolescent; Allopurinol; Cerebral Palsy; Delayed Diagnosis; Exons; Gout Suppressants; Humans; Hypoxanthine Phosphoribosyltransferase; Kidney Failure, Chronic; Lesch-Nyhan Syndrome; Male; Radiography, Thoracic; Renal Dialysis; Scoliosis; Uric Acid | 2020 |
Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.
Topics: Adult; AMP-Activated Protein Kinases; Animals; Atherosclerosis; Benzbromarone; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Female; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammasomes; Inflammation; Inflammation Mediators; Interleukin-18; Interleukin-1beta; Leukocytes, Mononuclear; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein; Nuclear Factor 45 Protein; Plaque, Atherosclerotic; Reactive Oxygen Species; Receptors, LDL; Urate Oxidase; Uric Acid; Uricosuric Agents; Xanthine Oxidase; Young Adult | 2020 |
Epigallocatechin gallate reduces uric acid levels by regulating xanthine oxidase activity and uric acid excretion in vitro and in vivo.
Topics: Animals; Antioxidants; Catechin; Liver; Monosaccharide Transport Proteins; Organic Anion Transporters, Sodium-Independent; Polyphenols; Rats; Rats, Sprague-Dawley; Tea; Uric Acid; Xanthine Oxidase | 2020 |
Structured patient care pathway for gout.
Topics: Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Patient Care; Uric Acid | 2020 |
Impact of Lesinurad and allopurinol on experimental Hyperuricemia in mice: biochemical, molecular and Immunohistochemical study.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Catalase; Drug Synergism; Glutathione Peroxidase; Gout Suppressants; Hyperuricemia; Interleukin-1beta; Kidney; Liver; Male; Mice; Thioglycolates; Triazoles; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2020 |
Efficacy and tolerability of febuxostat in gout patients on dialysis.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Renal Dialysis; Retrospective Studies; Treatment Outcome; Uric Acid | 2021 |
Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis.
Topics: Allopurinol; Animals; Antimetabolites; Diet, High-Fat; Enzyme Inhibitors; Fibroblast Growth Factors; Hepatocytes; Hyperuricemia; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Non-alcoholic Fatty Liver Disease; Triglycerides; Up-Regulation; Uric Acid; Xanthine Oxidase | 2020 |
Predictors of Hyperuricemia after Kidney Transplantation: Association with Graft Function.
Topics: Adult; Calcineurin Inhibitors; Diuretics; Female; Glomerular Filtration Rate; Graft Survival; Humans; Hyperuricemia; Kidney; Kidney Diseases, Cystic; Kidney Transplantation; Logistic Models; Longitudinal Studies; Male; Middle Aged; Postoperative Complications; Retrospective Studies; Risk Factors; Sex Factors; Transplants; Uric Acid; Xanthine Oxidase | 2020 |
Predictors of Success in Gout Treatment.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Uric Acid; Veterans | 2020 |
Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Female; Hemochromatosis; Hemochromatosis Protein; Homeostasis; Humans; Hyperuricemia; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Uric Acid; Xanthine Oxidase | 2020 |
High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout.
Topics: Allopurinol; Animal Structures; Animals; Chickens; Crystallization; Diet, High-Protein; Disease Models, Animal; Gout; Hyperuricemia; Kidney; Liver; Probenecid; Synovial Fluid; Uric Acid | 2020 |
Management of gout by Moroccan rheumatologists: a Moroccan Society for Rheumatology National Survey.
Topics: Allopurinol; Colchicine; Cross-Sectional Studies; Drug Therapy, Combination; Female; Gout; Gout Suppressants; Humans; Male; Morocco; Practice Patterns, Physicians'; Rheumatology; Surveys and Questionnaires; Uric Acid | 2020 |
Comparison of persistence rates between allopurinol and febuxostat as first-line urate-lowering therapy in patients with gout: an 8-year retrospective cohort study.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Middle Aged; Retrospective Studies; Uric Acid | 2020 |
A nurse-led, rheumatologist-assisted telemedicine intervention for dose escalation of urate-lowering therapy in gout.
Topics: Adult; Aged; Allopurinol; Biomarkers; Down-Regulation; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Nurse's Role; Patient Care Team; Program Evaluation; Proof of Concept Study; Rheumatologists; Rheumatology; Telemedicine; Time Factors; Treatment Outcome; Uric Acid | 2020 |
Blood glucose fluctuations detected by continuous glucose monitoring system in gout patients with normal glucose tolerance and the effect of urate-lowering therapy.
Topics: Adult; Aged; Allopurinol; Biomarkers; Blood Glucose; Blood Glucose Self-Monitoring; Down-Regulation; Female; Gout; Gout Suppressants; Humans; Hyperuricemia; Insulin Resistance; Male; Middle Aged; Predictive Value of Tests; Time Factors; Treatment Outcome; Uric Acid; Young Adult | 2020 |
RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.
Topics: Animals; Anti-Inflammatory Agents; Edema; Gout; Gout Suppressants; Humans; Hyperuricemia; Mice; Mice, Nude; Oryza; Peptides; Plant Extracts; Uric Acid; Xanthine Oxidase | 2020 |
Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout.
Topics: Adult; Aged; Allopurinol; Female; Gout; Gout Suppressants; Hospital Mortality; Hospitalization; Humans; Hyperuricemia; Kaplan-Meier Estimate; Male; Middle Aged; Retrospective Studies; Risk Assessment; Stroke; Taiwan; Treatment Outcome; Uric Acid; Young Adult | 2020 |
Urate-Lowering Therapy and Chronic Kidney Disease Progression.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Disease Progression; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uric Acid | 2020 |
[Comorbidity in gout and hyperuricemia: prevalence, causes, prospects of urate lowering therapy].
Topics: Allopurinol; Comorbidity; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Prevalence; Uric Acid | 2019 |
Efficacy of febuxostat versus allopurinol and the predictors of achieving target serum urate in a cohort of Thai people with gout.
Topics: Allopurinol; Cohort Studies; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Retrospective Studies; Thailand; Thiazoles; Treatment Outcome; Uric Acid | 2021 |
Comparison of uric acid reduction and renal outcomes of febuxostat vs allopurinol in patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Allopurinol; Cohort Studies; Febuxostat; Female; Follow-Up Studies; Glomerular Filtration Rate; Gout Suppressants; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Prognosis; Renal Insufficiency, Chronic; Taiwan; Uric Acid | 2020 |
The modulatory effects of cinnamaldehyde on uric acid level and IL-6/JAK1/STAT3 signaling as a promising therapeutic strategy against benign prostatic hyperplasia.
Topics: Acrolein; Animals; Biomarkers; Cell Proliferation; Cyclin D1; Gene Expression Regulation; Immunohistochemistry; Interleukin-6; Janus Kinase 1; Male; Prostate; Prostatic Hyperplasia; Rats; RNA, Messenger; STAT3 Transcription Factor; Uric Acid; Xanthine Oxidase | 2020 |
Achievement of the target serum urate level among patients with gout treated with allopurinol or febuxostat in an arthritis clinic in the Philippines.
Topics: Adult; Aged; Allopurinol; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Philippines; Treatment Outcome; Uric Acid | 2021 |
Latent Class Growth Analysis of Gout Flare Trajectories: A Three-Year Prospective Cohort Study in Primary Care.
Topics: Aged; Allopurinol; Disease Progression; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Primary Health Care; Symptom Flare Up; Uric Acid | 2020 |
Comparison of the Effects of Allopurinol and Febuxostat on the Values of Triglycerides in Hyperuricemic Patients.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Febuxostat; Female; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Prospective Studies; Retrospective Studies; Time Factors; Triglycerides; Uric Acid | 2020 |
[ERRORS IN THE DIAGNOSTICS AND TREATMENT OF PATIENTS WITH GOUT AND THE ALGORITHM OF THERAPEUTIC TACTICS IN DIFFERENT PERIODS OF THE DISEASE (CLINICAL CASE)].
Topics: Algorithms; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Gout; Humans; Uric Acid | 2020 |
[Large health benefits can be achieved by better treatment of gout].
Topics: Allopurinol; Colchicine; Gout; Gout Suppressants; Humans; Treatment Outcome; Uric Acid | 2020 |
Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.
Topics: Biomarkers, Tumor; Case-Control Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multiple Myeloma; NADPH Oxidase 1; Neoplasm Staging; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 2020 |
Allopurinol use and type 2 diabetes incidence among patients with gout: A VA retrospective cohort study.
Topics: Aged; Aged, 80 and over; Allopurinol; Colchicine; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gout; Gout Suppressants; Humans; Incidence; Male; Medication Adherence; Middle Aged; New York; Retrospective Studies; Time Factors; United States; United States Department of Veterans Affairs; Uric Acid | 2020 |
A Lanosteryl Triterpene (RA-3) Exhibits Antihyperuricemic and Nephroprotective Effects in Rats.
Topics: Animals; Biomarkers; Blood Urea Nitrogen; Body Weight; Creatinine; Hyperuricemia; Interleukin-6; Kidney; Lanosterol; Oxidative Stress; Protective Agents; Rats, Sprague-Dawley; Triterpenes; Uric Acid; Xanthine Oxidase | 2020 |
Uric Acid Is a Biomarker of Oxidative Stress in the Failing Heart: Lessons Learned from Trials With Allopurinol and SGLT2 Inhibitors.
Topics: Allopurinol; Biomarkers; Enzyme Inhibitors; Heart Failure; Humans; Oxidative Stress; Sodium-Glucose Transporter 2 Inhibitors; Uric Acid | 2020 |
Repair of Bone Erosion With Effective Urate-Lowering Therapy in a Patient With Tophaceous Gout.
Topics: Benzbromarone; Bone Resorption; Enzyme Inhibitors; Gout; Humans; Male; Metatarsal Bones; Metatarsophalangeal Joint; Middle Aged; Nitriles; Osteogenesis; Osteophyte; Pyridines; Treatment Outcome; Uric Acid; Uricosuric Agents; Xanthine Oxidase | 2021 |
Allopurinol: Good for Gout But Not for Preventing Loss of Kidney Function.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout; Gout Suppressants; Humans; Kidney; Uric Acid | 2021 |
Research in brief: Serum urate reduction and its effect on the progression of chronic kidney disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Disease Progression; Gout; Humans; Kidney; Renal Insufficiency, Chronic; Uric Acid | 2020 |
Non-purine selective xanthine oxidase inhibitor ameliorates glomerular endothelial injury in Ins
Topics: Albuminuria; Ameloblasts; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Kidney; Kidney Glomerulus; Mice; NADPH Oxidases; Oxidative Stress; Uric Acid; Xanthine Oxidase | 2020 |
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Topics: Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibitors; Flavanones; Glucose Transport Proteins, Facilitative; HEK293 Cells; Humans; Hyperuricemia; Kidney; Liver; Male; Mice; Molecular Docking Simulation; Organic Anion Transporters; Organic Cation Transport Proteins; Oxonic Acid; Uric Acid; Xanthine Oxidase | 2021 |
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis.
Topics: Animals; Cell Nucleus; Disease Models, Animal; Down-Regulation; Fibrosis; Hep G2 Cells; Humans; Hyperuricemia; Kidney; Male; Membrane Transport Proteins; Mice; Mice, Inbred ICR; NADPH Oxidases; NF-E2-Related Factor 2; Oxidative Stress; Protein Transport; Transcriptome; Umbelliferones; Ureteral Obstruction; Uric Acid; Xanthine Oxidase | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uric Acid | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uric Acid | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uric Acid | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uric Acid | 2020 |
Allopurinol and Chronic Kidney Disease.
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Renal Insufficiency, Chronic; Uric Acid | 2020 |
Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway.
Topics: Animals; Disease Models, Animal; Humans; Hyperuricemia; Inflammasomes; Luteolin; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Uric Acid; Xanthine Oxidase | 2021 |
Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Biomarkers; Disease Models, Animal; Fructose; Hyperuricemia; Kidney; Liver; Male; Membrane Transport Proteins; Rats, Sprague-Dawley; Renal Reabsorption; Uric Acid; Xanthine Oxidase; Xanthophylls | 2020 |
Combining Model-Based Clinical Trial Simulation, Pharmacoeconomics, and Value of Information to Optimize Trial Design.
Topics: Allopurinol; Bayes Theorem; Clinical Trials, Phase III as Topic; Computer Simulation; Decision Theory; Drug Development; Economics, Pharmaceutical; Febuxostat; Gout; Humans; Hyperuricemia; Investments; Models, Biological; Models, Economic; Reimbursement Mechanisms; Research Design; Sample Size; Uncertainty; Uric Acid | 2021 |
Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease - Japanese Guideline on the Management of Asymptomatic Hyperuricemia.
Topics: Allopurinol; Cardiovascular Diseases; Endothelial Cells; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Japan; Practice Guidelines as Topic; Renal Insufficiency, Chronic; Risk Factors; Uric Acid | 2021 |
[Evaluation of a 12-week allopurinol-lowering therapy in combination with the non-steroidal anti-inflammatory drug meloxicam in patients with gout].
Topics: Allopurinol; Drug Therapy, Combination; Gout; Gout Suppressants; Humans; Hyperuricemia; Meloxicam; Pharmaceutical Preparations; Quality of Life; Uric Acid | 2020 |
Serum Urate Lowering Therapy Using Allopurinol Improves Serum 25 Hydroxy Vitamin D in Stage 3-5 CKD Patients: A Pilot Study.
Topics: Adult; Allopurinol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Middle Aged; Pilot Projects; Uric Acid; Vitamin D | 2021 |
Hyperuricemia and progression of chronic kidney disease: to treat or not to treat?
Topics: Allopurinol; Diabetes Mellitus, Type 1; Gout Suppressants; Humans; Hyperuricemia; Kidney; Renal Insufficiency, Chronic; Uric Acid | 2021 |
Prevalence of Hyperuricemia and the Use of Allopurinol in Older Poles-Results from a Population-Based PolSenior Study.
Topics: Aged; Aged, 80 and over; Allopurinol; Cross-Sectional Studies; Female; Humans; Hyperuricemia; Male; Poland; Prevalence; Risk Factors; Uric Acid | 2021 |
Xanthine oxidase inhibitory activity and antihyperuricemic effect of Moringa oleifera Lam. leaf hydrolysate rich in phenolics and peptides.
Topics: Animals; Creatinine; Disease Models, Animal; Flavonoids; Gout Suppressants; Hyperuricemia; Malondialdehyde; Moringa oleifera; Organic Anion Transporters; Oxonic Acid; Peptides; Phenols; Plant Extracts; Plant Leaves; Rats; Triglycerides; Uric Acid; Xanthine Oxidase | 2021 |
Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice.
Topics: Animals; Cardiotoxicity; Doxorubicin; Febuxostat; Mice; Uric Acid; Xanthine Oxidase | 2021 |
Concomitant administration of HAART aggravates anti-Koch-induced oxidative hepatorenal damage via dysregulation of glutathione and elevation of uric acid production.
Topics: Aminohydrolases; Animals; Antiretroviral Therapy, Highly Active; Antitubercular Agents; Chemical and Drug Induced Liver Injury; DNA Fragmentation; Glutathione; Kidney Diseases; Lipid Peroxidation; Male; Monocytes; Oxidative Stress; Rats; Rats, Wistar; Reactive Nitrogen Species; Uric Acid; Xanthine Oxidase | 2021 |
Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats.
Topics: Adenosine Deaminase; Animals; Creatinine; Humans; Hyperuricemia; Kidney; Liver; Male; Oxonic Acid; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Uric Acid; Whey; Whey Proteins; Xanthine Oxidase | 2021 |
Allopurinol and Renal Outcomes in Adults With and Without Type 2 Diabetes: A Retrospective, Population-Based Cohort Study and Propensity Score Analysis.
Topics: Aged; Aged, 80 and over; Allopurinol; Diabetes Mellitus, Type 2; Female; Humans; Male; Propensity Score; Renal Insufficiency, Chronic; Retrospective Studies; Treatment Outcome; Uric Acid | 2021 |
Inosine induces acute hyperuricaemia in rhesus monkey (
Topics: Acute Disease; Allopurinol; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Febuxostat; Hyperuricemia; Imino Furanoses; Inosine; Macaca mulatta; Male; Pyrimidinones; Reproducibility of Results; Uric Acid | 2021 |
A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases.
Topics: Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Humans; Hyperuricemia; Kidney; Male; Middle Aged; Models, Statistical; Naphthalenes; Organic Anion Transporters; Organic Cation Transport Proteins; Propionates; Pyridines; Uric Acid; Xanthine Oxidase; Young Adult | 2021 |
Allopurinol Protects Against Cholestatic Liver Injury in Mice Not Through Depletion of Uric Acid.
Topics: 1-Naphthylisothiocyanate; Allopurinol; Animals; Cholestasis; Cholestasis, Intrahepatic; Liver; Mice; Uric Acid | 2021 |
Studies on effect of Tongfengxiaofang in HUM model mice using a UPLC-ESI-Q-TOF/MS metabolomic approach.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Drugs, Chinese Herbal; Hyperuricemia; Liver; Male; Metabolome; Metabolomics; Mice; Spectrometry, Mass, Electrospray Ionization; Uric Acid; Xanthine Oxidase | 2021 |
Different clinical impact of hyperuricemia according to etiologies of chronic kidney disease: Gonryo Study.
Topics: Adult; Aged; Allopurinol; Antimetabolites; Female; Glomerular Filtration Rate; Humans; Hyperuricemia; Kidney Failure, Chronic; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Renal Insufficiency, Chronic; Risk; Severity of Illness Index; Uric Acid | 2021 |
Drastic monosodium urate crystal dissolution with febuxostat and benzbromarone.
Topics: Allopurinol; Benzbromarone; Febuxostat; Gout; Gout Suppressants; Humans; Solubility; Uric Acid | 2021 |
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.
Topics: Animals; Catalytic Domain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Models, Molecular; Molecular Structure; Pyrimidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2021 |
Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway.
Topics: Allopurinol; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoplasmic Reticulum Stress; Fructose; Glucose Tolerance Test; Humans; Inflammation; Lipid Metabolism; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Inbred OLETF; Uric Acid; Xanthine Oxidase | 2021 |
Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.
Topics: Animals; Blood Urea Nitrogen; Chlorogenic Acid; Creatinine; Dietary Supplements; Gastrointestinal Microbiome; Homeostasis; Hyperuricemia; Hypoxanthine; Inflammation; Interleukin-1beta; Intestines; Kidney; Lipopolysaccharides; Male; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Oxonic Acid; Signal Transduction; Toll-Like Receptor 4; Uric Acid; Xanthine Oxidase | 2021 |
Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy.
Topics: Allopurinol; Animals; Blood Urea Nitrogen; Flavanones; Flavonoids; Kidney Diseases; Liver; Mice; Molecular Docking Simulation; Uric Acid; Xanthine Oxidase | 2021 |
Effects of Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Fructose and Potassium Oxonate.
Topics: Adenosine Triphosphate; Animals; Dendrobium; Fructose; Hyperuricemia; Kidney; Oxonic Acid; Plant Extracts; Plant Leaves; Rats; Uric Acid; Xanthine Oxidase | 2022 |
Cleroda-4(18),13-dien-15,16-olide as novel xanthine oxidase inhibitors: An integrated in silico and in vitro study.
Topics: Diterpenes, Clerodane; Enzyme Assays; Gout; Humans; Molecular Docking Simulation; Plant Extracts; Polyalthia; Seeds; Uric Acid; Xanthine Oxidase | 2021 |
Ameliorative effect and mechanism of Yi-Suan-Cha against hyperuricemia in rats.
Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Regulation; Hyperuricemia; Kidney; Male; Monosaccharide Transport Proteins; Organic Anion Transport Protein 1; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2021 |
CTRP3 ameliorates fructose-induced metabolic associated fatty liver disease via inhibition of xanthine oxidase-associated oxidative stress.
Topics: Adipokines; Animals; Fatty Acid Synthases; Fatty Liver; Feeding Behavior; Fructose; Lipids; Male; Oxidative Stress; Rats, Sprague-Dawley; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Uric Acid; Xanthine Oxidase | 2021 |
Omega-3 fatty acid rescues ischaemia/perfusion-induced testicular and sperm damage via modulation of lactate transport and xanthine oxidase/uric acid signaling.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Fatty Acids, Omega-3; Lactates; Male; Rats; Rats, Wistar; Reperfusion Injury; Signal Transduction; Spermatic Cord Torsion; Spermatozoa; Testis; Testosterone; Uric Acid; Xanthine Oxidase | 2021 |
Which is more important, xanthine oxidase activity or uric acid itself, in the risk for cardiovascular disease?
Topics: Cardiovascular Diseases; Enzyme Inhibitors; Humans; Hyperuricemia; Risk Factors; Uric Acid; Xanthine Oxidase | 2021 |
Underlying Mechanisms of Allopurinol in Eliminating Renal Toxicity Induced by Melamine-Uric Acid Complex Formation: A Computational Study.
Topics: Allopurinol; Hydrogen Bonding; Kidney Calculi; Molecular Dynamics Simulation; Static Electricity; Thermodynamics; Triazines; Uric Acid | 2021 |
Incorporating gout guideline advice into urate reports is associated with reduced hospital admissions: results of an observational study.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Hospitals; Humans; Treatment Outcome; Uric Acid | 2022 |
Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity.
Topics: Agaricales; Animals; Gout; Hyperuricemia; Inflammation; Inonotus; Mice; Triterpenes; Uric Acid; Xanthine Oxidase | 2022 |
Sesamol supplementation alleviates nonalcoholic steatohepatitis and atherosclerosis in high-fat, high carbohydrate and high-cholesterol diet-fed rats.
Topics: Animals; Aorta; Atherosclerosis; Benzodioxoles; Cholesterol, Dietary; Diet, High-Fat; Dietary Carbohydrates; Dietary Supplements; Eating; Endoplasmic Reticulum Stress; Lipid Metabolism; Liver; Male; Membrane Proteins; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Phenols; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Signal Transduction; Uric Acid; Weight Gain; Xanthine Oxidase | 2021 |
Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice.
Topics: Animals; Arthritis, Gouty; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2021 |
Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats.
Topics: Animals; Egg Shell; Humans; Hyperuricemia; Inflammation; Injections; Kidney; Kidney Function Tests; Male; Oocytes; Organic Anion Transporters; Oxonic Acid; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase; Xenopus | 2021 |
Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Berberine; Blood Urea Nitrogen; Chemical and Drug Induced Liver Injury; Creatinine; Cytokines; Disease Models, Animal; Glucose Transport Proteins, Facilitative; Hyperuricemia; Hypoxanthine; Janus Kinase 2; Kidney Diseases; Male; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Protective Agents; Signal Transduction; STAT3 Transcription Factor; Uric Acid; Xanthine Oxidase | 2021 |
In Vivo Effects of Orally Administered Different Concentrations of Silver Oxide Nanoparticles in Hyperuricemic Mice.
Topics: Allopurinol; Animals; Antioxidants; Arthritis, Gouty; Hyperuricemia; Lipids; Metal Nanoparticles; Mice; Nanoparticles; Oxides; Silver Compounds; Uric Acid | 2022 |
Hypouricemic, hepatoprotective and nephroprotective roles of oligopeptides derived from
Topics: Animals; Fish Proteins; Hyperuricemia; Kidney; Male; Mice; Oligopeptides; Protective Agents; Uric Acid; Xanthine Oxidase | 2021 |
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Topics: Animals; Antioxidants; Hyperuricemia; Hypoxanthine; Inflammation; Kidney; Male; Mice; Mice, Inbred ICR; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; Signal Transduction; Transcription Factor RelA; Uric Acid; Xanthine Oxidase; Xanthophylls | 2021 |
Isorhamnetin, the xanthine oxidase inhibitor from
Topics: Animals; Disease Models, Animal; Hyperuricemia; Kidney; Male; Mice; Quercetin; Sophora; Uric Acid; Xanthine Oxidase | 2021 |
Gout during the SARS-CoV-2 pandemic: increased flares, urate levels and functional improvement.
Topics: Allopurinol; COVID-19; Gout; Gout Suppressants; Humans; Male; Middle Aged; Pandemics; Prospective Studies; Quality of Life; SARS-CoV-2; Uric Acid | 2022 |
Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxid
Topics: Allopurinol; Carboxylic Acids; Drug Design; Enzyme Inhibitors; Febuxostat; Humans; Hydrogen Bonding; Models, Molecular; Pyrimidines; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2022 |
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors.
Topics: Animals; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hyperuricemia; Ligands; Models, Molecular; Molecular Structure; Oxonic Acid; Rats; Structure-Activity Relationship; Triazoles; Uric Acid; Xanthine Oxidase | 2022 |
Hyperuricemia is associated with secondary hyperparathyroidism in patients with chronic kidney disease.
Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Calcium; Cholecalciferol; Female; Furosemide; Humans; Hyperparathyroidism, Secondary; Hyperuricemia; Male; Middle Aged; Parathyroid Hormone; Phosphates; Renal Insufficiency, Chronic; Retrospective Studies; Uric Acid; Vitamin D; Vitamin D Deficiency | 2022 |
Effects of uric acid-lowering therapy in patients with essential arterial hypertension.
Topics: Adult; Aged; Allopurinol; Blood Pressure; C-Reactive Protein; Carotid Intima-Media Thickness; Essential Hypertension; Humans; Hypertension; Hyperuricemia; Middle Aged; Uric Acid | 2022 |
Why Do Patients With Gout Not Take Allopurinol?
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Male; Rheumatology; Treatment Outcome; Uric Acid | 2022 |
The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19.
Topics: Allopurinol; Biomarkers; Cohort Studies; COVID-19 Drug Treatment; Endothelium, Vascular; Ferritins; Humans; Oxidative Stress; Procalcitonin; Prospective Studies; SARS-CoV-2; Uric Acid | 2022 |
Lipegfilgrastim may cause hyperleukocytosis.
Topics: Allopurinol; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Middle Aged; Pain; Polyethylene Glycols; Uric Acid | 2022 |
Uricase-deficient rats with similarly stable serum uric acid to human's are sensitive model animals for studying hyperuricemia.
Topics: Allopurinol; Animals; Humans; Hyperuricemia; Kidney; Male; Rats; Urate Oxidase; Uric Acid | 2022 |
Treating gout - can hypouricemia produced by moderate doses of combined oral treatment give early treatment success? Preliminary observations.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Male; Treatment Outcome; Uric Acid | 2022 |
Novel anti-hyperuricemic hexapeptides derived from
Topics: Animals; Gastrointestinal Microbiome; Hyperuricemia; Mice; MicroRNAs; Molecular Docking Simulation; Stichopus; Uric Acid; Xanthine Oxidase | 2022 |
Uric acid, xanthine oxidase, and vascular damage: potential of xanthine oxidoreductase inhibitors to prevent cardiovascular diseases.
Topics: Cardiovascular Diseases; Enzyme Inhibitors; Humans; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2022 |
One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study.
Topics: Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Symptom Flare Up; Uric Acid | 2022 |
A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
Topics: Animals; Catalase; Creatinine; Cytokines; Flavonoids; Hyperuricemia; Inflammation; Kidney; Molecular Docking Simulation; Oxonic Acid; Plant Extracts; Rats; Superoxide Dismutase; Urea; Uric Acid; Xanthine Oxidase | 2022 |
Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis.
Topics: Animals; Fibrosis; Hyperuricemia; Inflammation; Iridoids; Kidney Diseases; Mice; Molecular Docking Simulation; Transforming Growth Factor beta; Uric Acid; Xanthine Oxidase | 2022 |
Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt.
Topics: Allopurinol; Animals; Arthritis, Gouty; Cymenes; Hyperuricemia; Inflammation; Male; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Rats; Rats, Sprague-Dawley; Uric Acid | 2022 |
Cardiovascular risk and mortality in patients with hyperuricemia treated with febuxostat or allopurinol: a retrospective nation-wide cohort study in Austria 2014-2017.
Topics: Aged; Allopurinol; Austria; Cardiovascular Diseases; Cohort Studies; Febuxostat; Female; Gout; Gout Suppressants; Heart Disease Risk Factors; Humans; Hyperuricemia; Ischemic Stroke; Male; Retrospective Studies; Risk Factors; Uric Acid | 2022 |
Pharmacokinetics, pharmacodynamics, and safety of verinurad with and without allopurinol in healthy Asian, Chinese, and non-Asian participants.
Topics: Allopurinol; China; Clinical Trials, Phase I as Topic; Drug Therapy, Combination; Humans; Male; Naphthalenes; Propionates; Pyridines; Randomized Controlled Trials as Topic; Uric Acid | 2022 |
Short Hexapeptide Optimized from Rice-Derived Peptide 1 Shows Promising Anti-hyperuricemia Activities.
Topics: Animals; Hyperuricemia; Kidney; Mice; Oryza; Peptides; Plant Proteins; Tissue Distribution; Uric Acid; Xanthine Oxidase | 2022 |
Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy.
Topics: Allopurinol; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; Heme Oxygenase-1; Hydralazine; Kidney; Mice; NADPH Oxidases; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Uric Acid | 2022 |
Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity.
Topics: Gastrointestinal Microbiome; Gout; Humans; Hyperuricemia; Inflammation; Lipopolysaccharides; Medicine, Chinese Traditional; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phytochemicals; Uric Acid; Xanthine Oxidase | 2022 |
Persistence with urate-lowering therapy in Australia: A longitudinal analysis of allopurinol prescriptions.
Topics: Allopurinol; Australia; Colchicine; Gout; Gout Suppressants; Humans; Male; Medication Adherence; Pharmaceutical Preparations; Prescriptions; Uric Acid | 2022 |
An association study of ABCG2 rs2231142 on the concentrations of allopurinol and its metabolites.
Topics: Allopurinol; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cross-Sectional Studies; Humans; Oxypurinol; Ribonucleosides; Uric Acid | 2022 |
Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3.
Topics: Animals; Caffeic Acids; Hyperuricemia; Kidney; Mice; Molecular Docking Simulation; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Oxonic Acid; Phenylethyl Alcohol; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2022 |
Synergistic Impacts of
Topics: Allopurinol; Alpinia; Animals; Creatinine; Drugs, Chinese Herbal; Hyperuricemia; Kidney; Plant Extracts; Rats; Seeds; Uric Acid; Xanthine Oxidase | 2022 |
Action mechanisms of two key xanthine oxidase inhibitors in tea polyphenols and their combined effect with allopurinol.
Topics: Allopurinol; Enzyme Inhibitors; Polyphenols; Tea; Uric Acid; Xanthine Oxidase | 2022 |
Hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester in hyperuricemic mice through inhibiting XOD and down-regulating URAT1.
Topics: Allopurinol; Animals; Benzbromarone; Esters; Hydroxybenzoates; Hyperuricemia; Kidney; Mice; Uric Acid; Xanthine Oxidase | 2022 |
POSSIBILITIES OF RENOPROTECTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERURICEMIA.
Topics: Allopurinol; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Renal Insufficiency, Chronic; Treatment Outcome; Uric Acid | 2022 |
Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink.
Topics: Allopurinol; Cohort Studies; COVID-19; Gout; Gout Suppressants; Humans; Pandemics; Uric Acid | 2022 |
Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia.
Topics: Animals; Antioxidants; Cornus; Gout; Hyperuricemia; Mice; Oxonic Acid; Plant Extracts; Uric Acid; Xanthine Oxidase | 2022 |
Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Topics: Allopurinol; Arrhythmias, Cardiac; Calcium; Extracellular Signal-Regulated MAP Kinases; Febuxostat; Humans; Induced Pluripotent Stem Cells; JNK Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Uric Acid; Xanthine Oxidase | 2022 |
Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes.
Topics: Adipocytes; Allopurinol; Colchicine; Enzyme Inhibitors; Fatty Acids, Nonesterified; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Inflammation; Lipolysis; Prospective Studies; Uric Acid; Xanthine Oxidase | 2022 |
Discovery of derivatives from Spartina alterniflora-sourced moiety as xanthine oxidase inhibitors to lower uric acid.
Topics: Allopurinol; Enzyme Inhibitors; Molecular Docking Simulation; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2022 |
Study on the interaction mechanism between luteoloside and xanthine oxidase by multi-spectroscopic and molecular docking methods.
Topics: Enzyme Inhibitors; Gout; Humans; Molecular Docking Simulation; Spectrometry, Fluorescence; Uric Acid; Xanthine Oxidase | 2022 |
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Topics: Allopurinol; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Colchicine; Creatinine; Drugs, Chinese Herbal; Gout; Humans; Hyperuricemia; Inflammation; Interleukin-18; Interleukin-6; Kidney; Mice; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; RNA, Messenger; Sirtuin 1; Stevia; Tumor Necrosis Factor-alpha; Uric Acid | 2022 |
Is febuxostat associated with higher risk of cardiovascular death than allopurinol in treating gout or asymptomatic hyperuricemia?
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Treatment Outcome; Uric Acid | 2022 |
Anserine beneficial effects in hyperuricemic rats by inhibiting XOD, regulating uric acid transporter and repairing hepatorenal injury.
Topics: Alanine Transaminase; Alkaline Phosphatase; Allopurinol; Animals; Anserine; ATP-Binding Cassette Transporters; Creatinine; Glucose Transport Proteins, Facilitative; Hyperuricemia; Hypoxanthines; Kidney; Liver; Malondialdehyde; Organic Anion Transporters; Potassium; Rats; Superoxide Dismutase; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2022 |
A possible covalent xanthine oxidase inhibitor TS10: Inhibition mechanism, metabolites identification and PDPK assessment.
Topics: Allopurinol; Enzyme Inhibitors; Molecular Docking Simulation; Uric Acid; Xanthine Oxidase | 2022 |
Monitoring and Achievement of Target Serum Urate Among Gout Patients Receiving Long-Term Urate-Lowering Therapy in the American College of Rheumatology RISE Registry.
Topics: Aged; Allopurinol; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Registries; Rheumatology; United States; Uric Acid | 2023 |
Semi-mechanistic Modeling of Hypoxanthine, Xanthine, and Uric Acid Metabolism in Asphyxiated Neonates.
Topics: Allopurinol; Clinical Studies as Topic; Humans; Hypoxanthine; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Mannitol; Oxypurinol; Uric Acid; Xanthine; Xanthine Dehydrogenase | 2022 |
Extraction optimization, structural characterization and potential alleviation of hyperuricemia by flavone glycosides from celery seeds.
Topics: Allopurinol; Animals; Apigenin; Apium; Cytochromes c; Flavones; Glycosides; Hyperuricemia; Luteolin; Mice; Plant Extracts; Rats; Seeds; Teas, Herbal; Uric Acid; Xanthine Oxidase | 2022 |
Short-Term Hyperuricemia Leads to Structural Retinal Changes That Can be Reversed by Serum Uric Acid Lowering Agents in Mice.
Topics: Allopurinol; Angiotensin II; Animals; Benzbromarone; Hyperuricemia; Macular Degeneration; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred ICR; Uric Acid | 2022 |
Modelling and assessing one- and two-drug dose titrations.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Hyperuricemia; Retrospective Studies; Uric Acid | 2022 |
Demographic and clinical profile of black patients with chronic kidney disease attending a tertiary hospital in Johannesburg, South Africa.
Topics: Acidosis; Aged; Allopurinol; Anemia; Bicarbonates; Cross-Sectional Studies; Diabetes Mellitus; Doxazosin; Hemoglobins; Humans; Hyperkalemia; Hypertension; Hyperuricemia; Middle Aged; Prevalence; Proteinuria; Renal Insufficiency, Chronic; South Africa; Tertiary Care Centers; Transferrins; Uric Acid | 2022 |
Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study.
Topics: Allopurinol; Animals; Benzhydryl Compounds; Erythropoietin; Gastrins; Male; Rats; Stomach; Uric Acid | 2022 |
Hypouricemic effect of gallic acid, a bioactive compound from
Topics: Adenosine Deaminase; Adenosine Triphosphatases; Animals; Creatinine; Cyclooxygenase 2; Cystatins; Gallic Acid; Hyperuricemia; Interleukin-6; Kidney; Lythraceae; Mice; Oxonic Acid; Superoxide Dismutase; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Uric Acid; Water; Xanthine Oxidase | 2022 |
A modified xanthine oxidase cell model for screening of antihyperuricemic functional compounds.
Topics: Adenosine; Febuxostat; Gout Suppressants; Humans; Hyperuricemia; Hypoxanthines; Peptides; Uric Acid; Xanthine Oxidase | 2022 |
Oxidative stress is the common causal link between renal stones and diabetes mellitus in adults.
Topics: Adult; Antioxidants; C-Reactive Protein; Case-Control Studies; Catalase; Creatinine; Diabetes Mellitus; Female; Glutathione Peroxidase; Humans; Iron; Lactates; Male; Malondialdehyde; Oxidative Stress; Superoxide Dismutase; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase; Young Adult | 2022 |
[Mechanism of total flavonoids from Ampelopsis grossedentata against gouty arthritis based on multi-level interactive network and in vivo experimental validation].
Topics: Ampelopsis; Animals; Arthritis, Gouty; Flavonoids; Interleukin-1beta; Interleukin-6; Myeloid Differentiation Factor 88; NF-kappa B; NLR Proteins; Rats; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2022 |
Allopurinol treatment reduced vascular remodeling and improved vascular functions in monocrotaline-induced pulmonary hypertensive rats.
Topics: Allopurinol; Animals; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Uric Acid; Vascular Remodeling | 2022 |
Hypouricemic and nephroprotective effects of palmatine from Cortex Phellodendri Amurensis: A uric acid modulator targeting Keap1-Nrf2/NLRP3 axis.
Topics: Animals; Creatinine; Hyperuricemia; Kelch-Like ECH-Associated Protein 1; Kidney; Mice; Molecular Docking Simulation; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Uric Acid; Xanthine Oxidase | 2023 |
Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Apoptosis; Atorvastatin; Caspase 3; Down-Regulation; Female; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Ischemia; Malondialdehyde; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha; Uric Acid; Vascular Cell Adhesion Molecule-1; Xanthine Oxidase | 2022 |
Disordered Glucose Levels Are Associated with Xanthine Oxidase Activity in Overweight Type 2 Diabetic Women.
Topics: Blood Glucose; C-Reactive Protein; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Male; Obesity; Overweight; Purine Nucleotides; Reactive Oxygen Species; Uric Acid; Xanthine Oxidase | 2022 |
Screening of lactic acid bacteria strains with urate-lowering effect from fermented dairy products.
Topics: Animals; Cultured Milk Products; Guanosine; Humans; Hyperuricemia; Lactobacillales; Rats; Uric Acid; Xanthine Oxidase | 2022 |
Predictors of Patient and Physician Assessments of Gout Control.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Symptom Flare Up; Uric Acid | 2023 |
Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Gouty; Edema; Hyperuricemia; Interleukin-8; Ligands; Matrix Metalloproteinase 9; Mice; Rats; Rodentia; Tumor Necrosis Factor-alpha; Uric Acid; Xanthine Oxidase | 2022 |
Gout in Dalarna, Sweden - a population-based study of gout occurrence and compliance to treatment guidelines.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Sweden; Treatment Outcome; Uric Acid | 2023 |
Exercise serum regulates uric acid transporters in normal rat kidney cells.
Topics: Animals; Hyperuricemia; Kidney; NF-kappa B; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2022 |
Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats.
Topics: Adenosine Deaminase; Animals; Antiretroviral Therapy, Highly Active; Caspase 3; Liver; Male; Non-alcoholic Fatty Liver Disease; Rats; Rats, Wistar; Triglycerides; Uric Acid; Xanthine Oxidase; Zinc | 2022 |
Cardiovascular risk of urate-lowering drugs: A study using the National Database of Health Insurance Claims and Specific Health Checkups of Japan.
Topics: Allopurinol; Benzbromarone; Cardiovascular Diseases; Febuxostat; Gout; Gout Suppressants; Heart Disease Risk Factors; Humans; Insurance, Health; Japan; Risk Factors; Treatment Outcome; Uric Acid | 2023 |
A retrospective observational study of the appropriate starting dose of febuxostat in patients with gout.
Topics: Adult; Aged; Allopurinol; Arthritis, Gouty; Febuxostat; Female; Gout; Gout Suppressants; Humans; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Uric Acid | 2023 |
Oxyberberrubine, a novel liver microsomes-mediated secondary metabolite of berberine, alleviates hyperuricemic nephropathy in mice.
Topics: Animals; Berberine; Hyperuricemia; Kidney; Mice; Microsomes, Liver; NLR Family, Pyrin Domain-Containing 3 Protein; Oxonic Acid; RNA, Messenger; Uric Acid; Xanthine Oxidase | 2023 |
The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics.
Topics: Allopurinol; Glucose Transport Proteins, Facilitative; Gout; Humans; Organic Anion Transporters; Organic Cation Transport Proteins; Oxypurinol; Uric Acid | 2023 |
Berberine Regulates the Metabolism of Uric Acid and Modulates Intestinal Flora in Hyperuricemia Rats Model.
Topics: Animals; Berberine; Gastrointestinal Microbiome; Hyperuricemia; Kidney; Male; Rats; Rats, Sprague-Dawley; RNA, Ribosomal, 16S; Uric Acid; Xanthine Oxidase | 2023 |
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Topics: Animals; Arthritis, Gouty; Cathepsin G; Female; Gout; Humans; Hyperuricemia; Inflammation; Interleukin-1beta; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Toll-Like Receptor 2; Uric Acid; Xanthine Oxidase | 2023 |
Assessment of the relationship between serum xanthine oxidase levels and type 2 diabetes: a cross-sectional study.
Topics: Adult; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Humans; Male; Prediabetic State; Uric Acid; Xanthine Oxidase | 2022 |
Flavonoid extract of saffron by-product alleviates hyperuricemia via inhibiting xanthine oxidase and modulating gut microbiota.
Topics: Animals; Crocus; Flavonoids; Flowers; Gastrointestinal Microbiome; Hyperuricemia; Plant Extracts; Rats; RNA, Ribosomal, 16S; Uric Acid; Xanthine Oxidase | 2022 |
Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Uric Acid; Xanthine Oxidase | 2022 |
Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction.
Topics: Animals; Chalcone; Chalcones; Enzyme Inhibitors; Gout; Hyperuricemia; Rats; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2023 |
Optimal uric acid reduction to improve vascular endothelial function in patients with chronic heart failure complicated by hyperuricemia.
Topics: Chronic Disease; Diuretics; Endothelium, Vascular; Enzyme Inhibitors; Heart Failure; Humans; Hyperemia; Hyperuricemia; Uric Acid; Xanthine Oxidase | 2023 |
Xanthine oxidoreductase mediates genotoxic drug-induced autophagy and apoptosis resistance by uric acid accumulation and TGF-β-activated kinase 1 (TAK1) activation.
Topics: Allopurinol; AMP-Activated Protein Kinases; Apoptosis; Autophagy; DNA Damage; Humans; MAP Kinase Kinase Kinases; Uric Acid; Xanthine Dehydrogenase | 2023 |
Changes in Tophus Composition During Urate-Lowering Therapy: A Dual-Energy Computed Tomography Study.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Tomography, X-Ray Computed; Uric Acid | 2023 |
[Effect of granules made by new-medicinal parts of Crocus sativus on hyperuricemia in rats and its mechanism].
Topics: Animals; Creatinine; Crocus; Hyperuricemia; Kidney; Kidney Diseases; Rats; Uric Acid; Xanthine Oxidase | 2022 |
Optimizing adherence to allopurinol for gout: patients' perspectives.
Topics: Allopurinol; Gout; Gout Suppressants; Humans; Medication Adherence; Uric Acid | 2023 |
Transdermal delivery of allopurinol to acute hyperuricemic mice
Topics: Administration, Oral; Allopurinol; Animals; Hyperuricemia; Mice; Polymers; Povidone; Uric Acid | 2023 |
Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents.
Topics: Allopurinol; Animals; Coumaric Acids; Humans; Hyperuricemia; Mice; Uric Acid; Xanthine Oxidase | 2023 |
Hypouricemic Actions of the Pericarp of Mangosteen
Topics: Animals; Garcinia mangostana; Hyperuricemia; Kidney; Mice; Rats; Uric Acid; Xanthine Oxidase | 2023 |
Global status and trends in gout research from 2012 to 2021: a bibliometric and visual analysis.
Topics: Bibliometrics; Gout; Humans; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Uric Acid; Xanthine Oxidase | 2023 |
[Anti-hyperuricemia activity and its mechanism of flavonoid extract from saffron floral bio-residues].
Topics: Adenine; Amino Acids; Animals; Antioxidants; Crocus; Ethambutol; Flavonoids; Hyperuricemia; Kidney; Lipids; Plant Extracts; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2023 |
Pharmacological evaluation of a novel skeleton compound isobavachin (4',7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity.
Topics: Animals; Flavones; Kidney; Molecular Docking Simulation; Rats; Rats, Sprague-Dawley; Uric Acid; Xanthine Oxidase | 2023 |
Design, synthesis and structure-activity relationship of N-phenyl aromatic amide derivatives as novel xanthine oxidase inhibitors.
Topics: Amides; Enzyme Inhibitors; Molecular Docking Simulation; Molecular Structure; Nitrogen Radioisotopes; Structure-Activity Relationship; Uric Acid; Xanthine Oxidase | 2023 |
Inhibition of Xanthine Oxidase Protects against Diabetic Kidney Disease through the Amelioration of Oxidative Stress via VEGF/VEGFR Axis and NOX-FoxO3a-eNOS Signaling Pathway.
Topics: Animals; Diabetic Nephropathies; Endothelial Cells; Febuxostat; Humans; Male; Mice; Mice, Inbred C57BL; NADPH Oxidases; Nitric Oxide Synthase Type III; Oxidative Stress; RNA, Messenger; Signal Transduction; Uric Acid; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xanthine Oxidase | 2023 |
Superiority of low-dose benzbromarone to low-dose febuxostat in gout patients with renal uric acid underexcretion: comment on the article by Yan et al.
Topics: Allopurinol; Benzbromarone; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Treatment Outcome; Uric Acid | 2023 |
In vivo anti-hyperuricemia and anti-gouty arthritis effects of the ethanol extract from Amomumvillosum Lour.
Topics: Arthritis, Gouty; Ethanol; Humans; Hyperuricemia; Plant Extracts; Uric Acid; Xanthine Oxidase | 2023 |
Comparison of benzbromarone and allopurinol on the risk of chronic kidney disease in people with asymptomatic hyperuricemia.
Topics: Allopurinol; Benzbromarone; Female; Gout Suppressants; Humans; Hyperuricemia; Male; Middle Aged; Renal Insufficiency, Chronic; Retrospective Studies; Uric Acid | 2023 |
Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice.
Topics: Allopurinol; Aminopropionitrile; Animals; Aortic Aneurysm, Thoracic; Aortic Dissection; Disease Models, Animal; Drinking Water; Hyperuricemia; Mice; Mice, Inbred C57BL; Receptors, IgG; RNA; Signal Transduction; Uric Acid | 2023 |
Amelioration effects of α-viniferin on hyperuricemia and hyperuricemia-induced kidney injury in mice.
Topics: Animals; Hyperuricemia; Interleukin-17; Kidney; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Uric Acid; Xanthine Oxidase | 2023 |
[ANMCO statement: Uric acid and cardiovascular disease: evidence and therapeutic approach].
Topics: Allopurinol; Cardiovascular Diseases; Gout; Gout Suppressants; Humans; Treatment Outcome; Uric Acid | 2023 |
In vitro xanthine oxidase inhibitory and in vivo anti-hyperuricemic properties of sodium kaempferol-3'-sulfonate.
Topics: Animals; Enzyme Inhibitors; Hyperuricemia; Kaempferols; Kinetics; Mice; Molecular Docking Simulation; Uric Acid; Xanthine Oxidase; Xanthines | 2023 |
Comparison between the Effects of Allopurinol and Febuxostat on the Survival of Patients on Maintenance Hemodialysis.
Topics: Allopurinol; Febuxostat; Gout; Gout Suppressants; Humans; Hyperuricemia; Renal Dialysis; Treatment Outcome; Uric Acid | 2023 |
Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.
Topics: Animals; Hyperuricemia; Kidney; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Organic Anion Transporters; Uric Acid; Xanthine Oxidase | 2023 |
Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway.
Topics: Flavonoids; Humans; Hyperuricemia; Inflammation; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Silk; Uric Acid; Xanthine Oxidase; Zea mays | 2023 |
Shizhifang ameliorates pyroptosis of renal tubular epithelial cells in hyperuricemia through inhibiting NLRP3 inflammasome.
Topics: Allopurinol; Animals; Caspases; China; Epithelial Cells; Humans; Hyperuricemia; Inflammasomes; Inflammation; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Signal Transduction; Uric Acid | 2023 |
Safety update: febuxostat and CVD.
Topics: Allopurinol; Cardiovascular Diseases; Febuxostat; Gout; Gout Suppressants; Humans; Treatment Outcome; Uric Acid | 2023 |
Gut microbiota mediated the therapeutic efficiency of Simiao decoction in the treatment of gout arthritis mice.
Topics: Allopurinol; Animals; Arthritis, Gouty; Gastrointestinal Microbiome; Inflammation; Mice; Uric Acid | 2023 |
Zinc protects against lead-induced testicular damage via modulation of steroidogenic and xanthine oxidase/uric acid/caspase 3-mediated apoptotic signaling in male Wistar rats.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Male; Oxidative Stress; Rats; Rats, Wistar; Semen; Testis; Testosterone; Uric Acid; Xanthine Oxidase; Zinc | 2023 |
Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats.
Topics: Animals; Antioxidants; Atherosclerosis; Diet, High-Fat; Enzyme Inhibitors; Febuxostat; Lipids; Non-alcoholic Fatty Liver Disease; Rats; Rats, Inbred SHR; Uric Acid; Xanthine Oxidase | 2023 |
Analysis of appropriate duration of colchicine prophylaxis to maximize the persistence of xanthine oxidase inhibitors as the first-line urate-lowering therapy in patients with gout using the Korean Health Insurance Review and Assessment Service database.
Topics: Adult; Allopurinol; Colchicine; Enzyme Inhibitors; Febuxostat; Gout; Gout Suppressants; Humans; Insurance Claim Review; Insurance, Health; Republic of Korea; Retrospective Studies; Uric Acid; Xanthine Oxidase; Young Adult | 2023 |
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Topics: Animals; Apigenin; Creatinine; Glucosides; Gout; Hyperuricemia; Kidney; Malondialdehyde; Mice; Molecular Docking Simulation; Organic Anion Transporters; Oxonic Acid; Paeonia; Superoxide Dismutase; Uric Acid; Xanthine Oxidase | 2023 |
Dispelling Dampness, Relieving Turbidity and Dredging Collaterals Decoction, Attenuates Potassium Oxonate-Induced Hyperuricemia in Rat Models.
Topics: Animals; Hyperuricemia; Interleukin-17; Kidney; Molecular Docking Simulation; Rats; Uric Acid; Xanthine Oxidase | 2023 |
Preliminary study on the material basis and mechanism underlying uric acid reduction by Thlaspi arvense L.
Topics: Animals; Flavonoids; Hyperuricemia; Rats; RNA, Messenger; Thlaspi; Uric Acid; Xanthine Oxidase | 2024 |
Natural mutations of human XDH promote the nitrite (NO
Topics: Humans; Hydrogen Peroxide; Mutation; Nitric Oxide; Nitrites; Nitrogen Dioxide; Oxidation-Reduction; Oxidoreductases; Uric Acid; Xanthine Dehydrogenase; Xanthine Oxidase | 2023 |
Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.
Topics: Adult; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colchicine; Diarrhea; Gout; Gout Suppressants; Humans; Myocardial Infarction; Propensity Score; Retrospective Studies; United Kingdom; Uric Acid | 2023 |
Peptide NCTX15 derived from spider toxin gland effectively relieves hyperuricemia in mice.
Topics: Animals; Gout; Hyperuricemia; Interleukin-6; Kidney; Mice; Uric Acid; Xanthine Oxidase | 2023 |