uric acid and 1,3-dimethyluric acid

uric acid has been researched along with 1,3-dimethyluric acid in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (35.38)	18.7374
1990's	21 (32.31)	18.2507
2000's	13 (20.00)	29.6817
2010's	8 (12.31)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fraisse, L; Rabion, A; Rascle, MC; Roche, B; Seris, JL; Verlhac, JB	1
Cameron, IL; Lyles, MB; Rawls, HR	1
Bertuzzi, F; Poje, M; Poje, N; Rocić, B; Vucić-Lovrencić, M	1
Bearne, SL; Lunn, FA; Roy, AC	1
Coates, PE; Elias-Jones, AC; Leakey, TE; Smith, KJ	1
Botteron, GW; Hughes, EM; Hurwitz, A; Jayaraj, A; Sztern, MI; Vacek, JL	1
Karnes, HT; Sarkar, MA	1
Grishanova, AIu; Guliaeva, LF; Mishin, VM; Vavilin, VA	1
Hasegawa, T; Kuzuya, T; Muraoka, I; Nadai, M; Takagi, K; Yoshizumi, H	1
Guzelian, PS; Hunt, C; Karnes, HT; Polk, RE; Sarkar, M	1
Advenier, C; Beaumont, D; Brion, N; Naline, E; Pays, M	1
Furuta, T; Kasuya, Y; Shimota, H	1
Guelen, PJ; Janssen, TJ; Vree, TB; Wijnands, GJ	1
Hori, R; Kishimoto, I; Okumura, K; Tanigawara, Y	1
Berdel, D; Bonnacker, I; Süverkrüp, R; von Berg, A	1
Birkett, DJ; Gregor, D; McManus, ME; Miners, JO; Stupans, I	1
Beck, R; Knoppert, DC; MacLeod, SM; Spino, M; Thiessen, JJ	1
Juan, D; Rammohan, M; Shin, SG	1
Rogge, MC; Sedman, AJ; Solomon, WR; Toothaker, RD; Wagner, JG; Welling, PG	1
Hafkenscheid, JC; Hekster, YA; Martea, M; Tiggeler, RG; Vree, TB	1
Beckmann, J; Elsässer, W; Gundert-Remy, U; Hertrampf, R	1
Levy, G; Ramzan, IM	1
Bompadre, S; Ercolani, P; Leone, L	1
du Souich, P; Hartemann, D; Saunier, C; Sautegeau, A	1
Gundert-Remy, U; Hildebrandt, R; Krüdewagen, B	1
Geoffroy, S; Gilbert, SG; Klassen, RD; Rice, DC; So, Y; Stavric, B	1
Ainardi, V; Opheim, KE; Raisys, VA	1
Berdel, D; Heimann, G	1
Gundert-Remy, U; Hildebrandt, R; Möller, H; Weber, E	1
Attwood, J; Birkett, DJ; Miners, JO	1
Riegelman, S; Tang-Liu, DD; Williams, RL	1
Birkett, DJ; Grygiel, JJ	1
Jonkman, JH; Riegelman, S; Tang, D; Upton, RA	1
Aarons, L; Davis, JD; Houston, JB	1
Chen, J; Follath, F; Freiburghaus, AU; Ha, HR	1
Kaminsky, LS; Zhang, ZY	1
Brøsen, K; Nielsen, KK; Rasmussen, BB	1
Konishi, H; Morita, K; Yamaji, A	1
Iwaki, M; Ogiso, T; Okuyama, K; Tanino, T; Uno, S	1
Iga, T; Kawakami, J; Sawada, Y; Toyama, E; Yamamoto, K	1
Fujiwara, I; Mizuki, Y; Sekine, Y; Yamaguchi, T	1
Bantle, JA; Fort, DJ; Hull, MA; Propst, T; Stover, EL	1
Norman, A; Rodopoulos, N	1
Asoh, M; Kobayashi, S; Koitabashi, Y; Okano, YJ; Tateishi, T; Yamaguchi, A; Yoda, T	1
Kim, J; Ko, G; Park, EJ; Sohn, DH	1
Kuh, HJ; Shim, CK	1
Cao, W; Chen, G; Ling, SS; Zhuo, HT	1
Hsieh, YS; Kuo, HW; Maa, MC; Wang, CJ; Yuan, SC	1
Chung, HC; Kim, EJ; Kim, SG; Kim, SH; Lee, I; Lee, MG; Yu, SY	1
Kim, EJ; Lee, MG; Suh, OK	1
Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Kim, SG; Kim, SH; Kim, YC; Lee, AK; Lee, DC; Lee, I; Lee, JH; Lee, MG	1
Chang, YS; Kim, JQ; Park, HD; Park, KU; Song, J; Yoon, Y	1
Hasegawa, T; Kato, M; Kimura, M; Nadai, M; Tsunekawa, Y; Ueyama, J; Yasui, K; Yoshizumi, H; Zhao, YL	1
Bae, SK; Choi, HD; Chung, HJ; Kang, HE; Lee, MG; Shin, KN	1
Lee, JH; Lee, MG; Yang, KH	1
Jung, YS; Kim, YC; Lee, DY; Lee, JH; Lee, MG; Yang, KH	1
Gopishetty, S; Kale, Y; Louie, TM; Subramanian, M; Summers, R; Yu, CL	1
Chohnabayashi, N; Kizu, J; Nasu, H; Nishimura, N; Uchiyama, N; Watanabe, Y	1
Pfleiderer, W; Suzuki, T; Yamamoto, H	1
Chae, JW; Kim, DH; Kim, Ej; Kwon, KI; Lee, BY	1
Aravind, UK; Aravindakumar, CT; Pramod, G; Saha, A; Sunil Paul, MM	1
Chen, XY; Liu, Y; Zhan, Y; Zhang, YF; Zhong, DF	1
Ahluwalia, N; Pao, CI; Pfeiffer, CM; Rybak, ME; Sternberg, MR	1
Enoki, Y; Hori, S; Kizu, J; Kuroda, Y; Matsumoto, K; Taguchi, K	1

Trials

4 trial(s) available for uric acid and 1,3-dimethyluric acid

Article	Year
Cystic fibrosis: enhanced theophylline metabolism may be linked to the disease. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Adolescent; Adult; Biotransformation; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Cystic Fibrosis; Double-Blind Method; Humans; Male; Random Allocation; Theophylline; Uric Acid; Xanthines	1988
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children]. Wiener klinische Wochenschrift, 1984, Aug-31, Volume: 96, Issue:16 Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; Infant, Newborn; Infant, Premature; Kinetics; Theophylline; Uric Acid; Xanthines	1984
Effect of fluconazole on theophylline disposition in humans. European journal of clinical pharmacology, 1994, Volume: 46, Issue:4 Topics: Adult; Cross-Over Studies; Enoxacin; Female; Fluconazole; Humans; Male; Metabolic Clearance Rate; Theophylline; Uric Acid; Xanthines	1994
Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios. European journal of clinical pharmacology, 2006, Volume: 62, Issue:8 Topics: Alleles; Asthma; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Genotype; Humans; Pharmacogenetics; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Theophylline; Uric Acid	2006

Other Studies

61 other study(ies) available for uric acid and 1,3-dimethyluric acid

Article	Year
Long-chain-substituted uric acid and 5,6-diaminouracil derivatives as novel agents against free radical processes: synthesis and in vitro activity. Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10 Topics: Animals; Antioxidants; Cattle; Free Radical Scavengers; Lipid Peroxidation; Mitochondria, Heart; Pyrimidines; Structure-Activity Relationship; Uracil; Uric Acid	1993
Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26 Topics: Acridine Orange; Intercalating Agents; Methylation; Nonlinear Dynamics; Spectrophotometry; Structure-Activity Relationship; Xanthines	2001
Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic beta-cells. Bioorganic & medicinal chemistry letters, 2005, Feb-15, Volume: 15, Issue:4 Topics: Animals; Arginine; Glucose; Hyperuricemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Protein Binding; Rats; Structure-Activity Relationship; Uric Acid	2005
Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Kinetics; Methylation; Structure-Activity Relationship; Uric Acid; Xanthines	2010
Pharmacokinetics of theophylline and its metabolites during acute renal failure. A case report. Clinical pharmacokinetics, 1991, Volume: 21, Issue:5 Topics: Acute Kidney Injury; Asthma; Child, Preschool; Humans; Male; Metabolic Clearance Rate; Peritoneal Dialysis; Theophylline; Uric Acid	1991
Mexiletine effects on theophylline disposition. Clinical pharmacology and therapeutics, 1991, Volume: 50, Issue:3 Topics: Adult; Delayed-Action Preparations; Drug Interactions; Humans; Male; Mexiletine; Theophylline; Uric Acid	1991
High performance liquid chromatographic determination of theophylline metabolites in human liver microsomes. Biomedical chromatography : BMC, 1991, Volume: 5, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Microchemistry; Microsomes, Liver; Quality Control; Uric Acid; Xanthines	1991
[Theophylline metabolism by rat liver microsomal monooxygenases]. Biokhimiia (Moscow, Russia), 1990, Volume: 55, Issue:10 Topics: Animals; Antibodies, Monoclonal; Cytochrome P-450 Enzyme System; Enzyme Induction; In Vitro Techniques; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Neprilysin; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1990
Effects of enoxacin on renal and metabolic clearance of theophylline in rats. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:9 Topics: Animals; Enoxacin; Kidney; Male; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1990
In vitro effect of fluoroquinolones on theophylline metabolism in human liver microsomes. Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:4 Topics: Biotransformation; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Enoxacin; Humans; Hydroxylation; Microsomes, Liver; Norfloxacin; Theophylline; Uric Acid; Xanthines	1990
Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects. British journal of clinical pharmacology, 1989, Volume: 27, Issue:3 Topics: Adult; Benzhydryl Compounds; Drug Interactions; Humans; Male; Terfenadine; Theophylline; Time Factors; Uric Acid; Xanthines	1989
Capillary gas chromatographic-mass spectrometric determination of stable isotopically labelled and unlabelled theophylline in serum and urine and of 1,3-dimethyluric acid in urine. Journal of chromatography, 1989, Sep-29, Volume: 494 Topics: Alkylation; Carbon Isotopes; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Nitrogen Isotopes; Reference Standards; Theophylline; Uric Acid	1989
Drug-drug interactions affecting fluoroquinolones. The American journal of medicine, 1989, Dec-29, Volume: 87, Issue:6C Topics: Adult; Drug Interactions; Enoxacin; Humans; Male; Ofloxacin; Oxidation-Reduction; Theophylline; Uric Acid; Xanthines	1989
Blood oxygen tension-related change of theophylline clearance in experimental hypoxemia. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Animals; Hypoxia; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Oxygen; Partial Pressure; Rats; Rats, Inbred Strains; Theophylline; Uric Acid	1989
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients. European journal of clinical pharmacology, 1989, Volume: 36, Issue:2 Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; Theophylline; Uric Acid; Urodynamics; Xanthines	1989
Theophylline metabolism by human, rabbit and rat liver microsomes and by purified forms of cytochrome P450. The Journal of pharmacy and pharmacology, 1988, Volume: 40, Issue:6 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Theophylline; Uric Acid; Xanthines	1988
Theophylline pharmacokinetics in normal elderly subjects. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theophylline; Uric Acid; Xanthines	1988
The theophylline-enoxacin interaction: I. Effect of enoxacin dose size on theophylline disposition. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Drug Interactions; Enoxacin; Humans; Male; Theophylline; Uric Acid; Xanthines	1988
Pharmacokinetics of theophylline and its metabolites in a patient undergoing continuous ambulatory peritoneal dialysis. Clinical pharmacokinetics, 1988, Volume: 15, Issue:6 Topics: Aged; Humans; Kidney Failure, Chronic; Male; Peritoneal Dialysis, Continuous Ambulatory; Theophylline; Uric Acid; Xanthines	1988
Enoxacin--a potent inhibitor of theophylline metabolism. European journal of clinical pharmacology, 1987, Volume: 33, Issue:3 Topics: Adult; Anti-Infective Agents; Enoxacin; Humans; Naphthyridines; Theophylline; Uric Acid; Xanthines	1987
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3 Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Rats; Rats, Inbred Lew; Seizures; Theophylline; Uric Acid; Xanthines	1986
[Determination of theophylline in the plasma by rapid solid-phase extraction]. Bollettino della Societa italiana di biologia sperimentale, 1987, Aug-31, Volume: 63, Issue:8 Topics: Chromatography, High Pressure Liquid; Humans; Lung Diseases, Obstructive; Theophylline; Uric Acid; Xanthines	1987
Theophylline disposition during acute and chronic hypoxia in the conscious dog. Research communications in chemical pathology and pharmacology, 1987, Volume: 57, Issue:3 Topics: Acute Disease; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Dogs; Female; Hypoxia; Male; Theophylline; Uric Acid; Xanthines	1987
Plasma concentrations of theophylline and its metabolites in a theophylline intoxicated child--reevaluation of published Km-values. British journal of clinical pharmacology, 1986, Volume: 22, Issue:5 Topics: Hemoperfusion; Humans; Infant; Kinetics; Theophylline; Uric Acid; Xanthines	1986
Elimination of chronically consumed caffeine in the pregnant monkey (Macaca fascicularis). The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:3 Topics: Animals; Caffeine; Chromatography, High Pressure Liquid; Drinking; Eating; Female; Macaca fascicularis; Pregnancy; Pregnancy, Animal; Theophylline; Uric Acid	1986
Increase in apparent theophylline concentration in the serum of two patients as measured by some immunoassay methods (caused by 1,3-dimethyluric acid?) Clinical chemistry, 1983, Volume: 29, Issue:9 Topics: Chromatography, High Pressure Liquid; False Positive Reactions; Humans; Immunoenzyme Techniques; Reagent Kits, Diagnostic; Theophylline; Uremia; Uric Acid	1983
Lack of clinically important interaction between erythromycin and theophylline. European journal of clinical pharmacology, 1984, Volume: 26, Issue:4 Topics: Adult; Drug Interactions; Erythromycin; Female; Half-Life; Humans; Infusions, Parenteral; Injections, Intravenous; Kinetics; Male; Theophylline; Uric Acid; Xanthines	1984
Secondary metabolism of theophylline biotransformation products in man--route of formation of 1-methyluric acid. British journal of clinical pharmacology, 1983, Volume: 15, Issue:1 Topics: Biotransformation; Humans; Male; Theophylline; Uric Acid; Xanthines	1983
Nonlinear theophylline elimination. Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3 Topics: Administration, Oral; Adult; Aminophylline; Biotransformation; Female; Humans; Infusions, Parenteral; Kinetics; Male; Models, Biological; Theophylline; Time Factors; Uric Acid; Xanthines	1982
Cigarette smoking and theophylline clearance and metabolism. Clinical pharmacology and therapeutics, 1981, Volume: 30, Issue:4 Topics: Adult; Biotransformation; Cytochrome P-450 Enzyme System; Female; Humans; Male; Metabolic Clearance Rate; Smoking; Theophylline; Uric Acid; Xanthines	1981
Measurement of excretion characteristics of theophylline and its major metabolites. European journal of clinical pharmacology, 1981, Volume: 20, Issue:6 Topics: Humans; Kinetics; Theophylline; Uric Acid; Xanthines	1981
Metabolism of theophylline and its inhibition by fluoroquinolones in rat hepatic microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 1995, Volume: 25, Issue:6 Topics: Animals; Anti-Infective Agents; Benzoflavones; beta-Naphthoflavone; Coumarins; Cytochrome P-450 Enzyme System; Enoxacin; In Vitro Techniques; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Xanthines	1995
Metabolism of theophylline by cDNA-expressed human cytochromes P-450. British journal of clinical pharmacology, 1995, Volume: 39, Issue:3 Topics: Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Induction; Epoxide Hydrolases; Humans; Hydroxylation; Isoenzymes; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Regression Analysis; Smoking; Theophylline; Tumor Cells, Cultured; Uric Acid; Xanthines	1995
Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. Biochemical pharmacology, 1995, Jul-17, Volume: 50, Issue:2 Topics: Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; Isoenzymes; Kinetics; Methylation; Microsomes, Liver; Oxidoreductases; Theophylline; Transfection; Uric Acid	1995
Determination of theophylline metabolites in human liver microsomes by high-performance liquid chromatography. Analytical biochemistry, 1994, Volume: 222, Issue:1 Topics: Chromatography, High Pressure Liquid; Humans; Microsomes, Liver; Reproducibility of Results; Spectrophotometry, Ultraviolet; Uric Acid; Xanthines	1994
Effect of mexiletine on elimination and metabolic conversion of theophylline and its major metabolites in rats. Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:2 Topics: Administration, Oral; Aminophylline; Animals; In Vitro Techniques; Injections, Intravenous; Liver; Male; Mexiletine; Rats; Rats, Wistar; Theophylline; Uric Acid; Xanthines	1993
Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:6 Topics: Animals; Blood-Brain Barrier; Brain; Infusions, Intravenous; Injections, Intraventricular; Male; Mice; Neurotoxins; Seizures; Theophylline; Uric Acid; Xanthines	1996
Structure-related inhibitory effect of antimicrobial enoxacin and derivatives on theophylline metabolism by rat liver microsomes. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:8 Topics: Animals; Anti-Infective Agents; Crystallography, X-Ray; Electrochemistry; Enoxacin; Male; Methylcholanthrene; Microsomes, Liver; Molecular Conformation; Molecular Structure; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Theophylline; Uric Acid	1996
Evaluation of the developmental toxicity of theophylline, dimethyluric acid, and methylxanthine metabolites using Xenopus. Drug and chemical toxicology, 1996, Volume: 19, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Embryo, Nonmammalian; Embryonic and Fetal Development; Female; In Vitro Techniques; Male; Theophylline; Uric Acid; Xanthines; Xenopus laevis	1996
Elimination of theophylline metabolites in healthy adults. Scandinavian journal of clinical and laboratory investigation, 1997, Volume: 57, Issue:3 Topics: Administration, Oral; Adult; Female; Humans; Male; Middle Aged; Theophylline; Time Factors; Uric Acid; Xanthines	1997
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients. Pediatric research, 1999, Volume: 45, Issue:1 Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Theophylline; Uric Acid; Xanthines	1999
Biotransformation of theophylline in cirrhotic rats induced by biliary obstruction. Archives of pharmacal research, 1999, Volume: 22, Issue:1 Topics: Animals; Area Under Curve; Biotransformation; Body Weight; Bronchodilator Agents; Cholestasis; Half-Life; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Microsomes, Liver; Organ Size; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid	1999
Nonlinear renal excretion of theophylline and its metabolites, 1-methyluric acid and 1,3-dimethyluric acid, in rats. Archives of pharmacal research, 1994, Volume: 17, Issue:2 Topics: Animals; Biotransformation; Bronchodilator Agents; Infusions, Intravenous; Injections, Intravenous; Male; Nonlinear Dynamics; Probenecid; Rats; Rats, Wistar; Renal Agents; Theophylline; Uric Acid	1994
Pharmacokinetics of theophylline metabolites in 8 Chinese patients. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1998, Volume: 19, Issue:5 Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophylline; Uric Acid; Xanthines	1998
Effect of tea and coffee consumption on serum uric acid levels by liquid-chromatographic and uricase methods. Bulletin of environmental contamination and toxicology, 2000, Volume: 65, Issue:3 Topics: Chromatography, High Pressure Liquid; Coffee; Diet; Female; Gout; Humans; Male; Tea; Urate Oxidase; Uric Acid	2000
Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:12 Topics: Acute Kidney Injury; Aminophylline; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Data Interpretation, Statistical; Drug Interactions; Enzyme Induction; Half-Life; In Vitro Techniques; Infusions, Intravenous; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Time Factors; Uranyl Nitrate; Uric Acid	2002
Pharmacokinetics of intravenous theophylline in mutant Nagase analbuminemic rats. Life sciences, 2003, Jan-31, Volume: 72, Issue:11 Topics: Animals; Area Under Curve; Blood Protein Disorders; Cytochrome P-450 CYP1A2; Enzyme Induction; Infusions, Intravenous; Kidney; Male; Metabolic Clearance Rate; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Serum Albumin; Theophylline; Uric Acid	2003
High-throughput liquid chromatography-tandem mass spectrometry assay for plasma theophylline and its metabolites. Clinical chemistry, 2004, Volume: 50, Issue:11 Topics: Bronchodilator Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Plasma; Theophylline; Uric Acid; Xanthines	2004
Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2005, Volume: 26, Issue:1 Topics: Administration, Oral; Alloxan; Aminophylline; Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Diabetes Mellitus, Experimental; Enzyme Induction; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Theophylline; Uric Acid	2005
Lack of effect of aciclovir on metabolism of theophylline and expression of hepatic cytochrome P450 1A2 in rats. Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3 Topics: Acyclovir; Animals; Antiviral Agents; Blotting, Western; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Wistar; Theophylline; Uric Acid; Vasodilator Agents; Xanthines	2007
Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:8 Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Bronchodilator Agents; Dehydration; Half-Life; Injections, Intravenous; Male; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Water Deprivation	2007
Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU. The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:1 Topics: Animals; Area Under Curve; Benz(a)Anthracenes; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Activators; Half-Life; Infusions, Intravenous; Isoniazid; Metabolic Clearance Rate; Methylcholanthrene; Orphenadrine; Phosphodiesterase Inhibitors; Protein Binding; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid; Weight Gain	2008
Time-dependent effects of Klebsiella pneumoniae endotoxin (KPLPS) on the pharmacokinetics of theophylline in rats: return of the parameters in 96-hour KPLPS rats to the control levels. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:5 Topics: Administration, Oral; Animals; Bronchodilator Agents; Cytochrome P-450 Enzyme System; Infusions, Intravenous; Klebsiella pneumoniae; Lipopolysaccharides; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Theophylline; Uric Acid	2008
Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5. Journal of bacteriology, 2009, Volume: 191, Issue:14 Topics: Caffeine; Gene Expression; Metabolic Networks and Pathways; Pseudomonas putida; Theobromine; Theophylline; Uric Acid; Xanthine; Xanthines	2009
Usefulness of the simultaneous determination of serum levels of theophylline and its metabolites in patients medicated with theophylline preparation. Biomedical chromatography : BMC, 2011, Volume: 25, Issue:4 Topics: Asthma; Bronchodilator Agents; Caffeine; Chromatography, High Pressure Liquid; Humans; Smoking; Theophylline; Uric Acid	2011
Nitrosation of N-methyl derivatives of uric acid and their transnitrosation ability to N-acetylcysteine. Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:9 Topics: Acetylcysteine; Nitric Oxide; Nitrosation; Uric Acid	2010
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Mar-15, Volume: 889-890 Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2012
Hydroxyl radical induced oxidation of theophylline in water: a kinetic and mechanistic study. Organic & biomolecular chemistry, 2014, Aug-14, Volume: 12, Issue:30 Topics: Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxyl Radical; Hydroxylation; Kinetics; Light; Mass Spectrometry; Methylation; Oxidation-Reduction; Pulse Radiolysis; Spectrum Analysis; Theophylline; Uric Acid; Water; Xanthine	2014
[Quantitative analysis of theophylline and its metabolites in urine of Chinese healthy subjects after oral administration of theophylline sustained-release tablets]. Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:7 Topics: Administration, Oral; Asian People; Calibration; Chromatography, Liquid; Delayed-Action Preparations; Healthy Volunteers; Humans; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry; Theophylline; Uric Acid; Xanthines	2014
Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake. The Journal of nutrition, 2015, Volume: 145, Issue:4 Topics: Adolescent; Adult; Biomarkers; Black or African American; Caffeine; Child; Chromatography, Liquid; Cross-Sectional Studies; Female; Hispanic or Latino; Humans; Male; Middle Aged; Nutrition Surveys; Tandem Mass Spectrometry; Theophylline; Uracil; Uric Acid; White People; Xanthines; Young Adult	2015
Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice. Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:8 Topics: Aging; Animals; Male; Mice, Inbred ICR; Theophylline; Uric Acid	2019