urethane-acrylate and 2-methacryloyloxyethyl-phosphorylcholine

In order to develop a simple, economical and rapid approach to incorporate 2-methacryloyloxyethyl phosphorylcholine (MPC) with other monomers without any solvent, we prepared a series of ultraviolet cured poly(urethane acrylate) (PUA) membranes containing different MPC content. Their chemical structure and surface properties were investigated by FT-IR, XPS, water swelling ratio and water contact angle measurement, while the biocompatibilities were evaluated through fibrinogen adsorptions, platelet adhesion and plasma recalcification time determination. The results demonstrate that the phosphorylcholine (PC) groups were successfully introduced into the PUA system by the UV-curing approach and the all PC-containing membranes showed better biocompatibility than those without PC moiety. The UV-curing method is potentially to be applied in the coating of medical devices which require biocompatibility and manufacturing efficiency.

Topics: Acrylic Resins; Calcification, Physiologic; Fibrinogen; Humans; Hydrophobic and Hydrophilic Interactions; Materials Testing; Membranes, Artificial; Methacrylates; Molecular Structure; Muramidase; Phosphorylcholine; Plasma; Platelet Adhesiveness; Polyurethanes; Solvents; Surface Properties; Ultraviolet Rays; Water