urea has been researched along with trimethyloxamine in 143 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.50) | 18.7374 |
| 1990's | 12 (8.39) | 18.2507 |
| 2000's | 41 (28.67) | 29.6817 |
| 2010's | 65 (45.45) | 24.3611 |
| 2020's | 20 (13.99) | 2.80 |
| Authors | Studies |
|---|---|
| Law, RO | 1 |
| Anderson, PM; Shankar, RA | 1 |
| Fridovich, I; Mashino, T | 1 |
| Anderson, PM | 2 |
| Weber, RE | 1 |
| Lin, TY; Timasheff, SN | 1 |
| Caruso-Neves, C; Vieyra, A | 1 |
| Guppy, M; Withers, PC | 1 |
| Bolen, DW; Wang, A | 1 |
| Sackett, DL | 1 |
| Burg, MB; Peters, EM | 2 |
| Baskakov, I; Bolen, DW | 1 |
| Baskakov, I; Bolen, DW; Wang, A | 1 |
| Ballantyne, JS; Barton, KN; Buhr, MM | 1 |
| Aouffen, M; Mateescu, MA; Nadeau, R; Wang, R; Wang, X; Wu, L | 1 |
| Alexandrescu, AT; Jaravine, VA; Rathgeb-Szabo, K | 1 |
| Bedford, JJ; Leader, JP; Palmer, HR; Smith, RA | 1 |
| Brittain, T | 1 |
| Brange, J; Coats, A; Fink, AL; Frokjaer, S; Khurana, R; Nielsen, L; Uversky, VN; Vyas, S | 1 |
| Larsen, BK; Schlenk, D | 1 |
| Goldstein, L; Koomoa, DL; MacLean, AV; Musch, MW | 1 |
| Galinski, EA; Lever, M; Randall, K | 1 |
| Bennion, BJ; Daggett, V; Murphy, KP; Zou, Q | 1 |
| Driedzic, WR; Ewart, KV; Richards, RC; Treberg, JR; Wilson, CE | 1 |
| Celinski, SA; Scholtz, JM | 1 |
| Ortiz-Costa, S; Sola-Penna, M; Sorenson, MM | 1 |
| Gluick, TC; Yadav, S | 1 |
| Bolen, DW; Qu, Y | 1 |
| Barrick, D; Mello, CC | 1 |
| Schellman, JA | 1 |
| Banerjee, R; Bhattacharyya, A; Lahiri, S; Mandal, AK; Roy, S; Samaddar, S | 1 |
| Bolen, DW; Rösgen, J; Russo, AT | 1 |
| Ballantyne, JS; Morgan, RL; Wright, PA | 1 |
| Arakawa, T; Ishibashi, M; Sakashita, K; Tokunaga, H; Tokunaga, M | 1 |
| Cooper, AR; Morris, S | 1 |
| Bennion, BJ; Daggett, V | 1 |
| Steele, SL; Wright, PA; Yancey, PH | 1 |
| Pradeep, L; Udgaonkar, JB | 1 |
| Bedford, JJ; Leader, JP; Samuelsson, LM; Smith, RA | 1 |
| Beuria, TK; Mukherjee, A; Panda, D; Santra, MK | 1 |
| Koch, MH; Niebuhr, M | 1 |
| Kajimura, M; Mommsen, TP; Walsh, PJ; Wood, CM | 1 |
| Callender, R; Gulotta, M; Qiu, L | 1 |
| Draper, DE; Lambert, D | 1 |
| Patey, GN; Paul, S | 2 |
| Olsen, SN; Ramløv, H; Westh, P | 1 |
| Bolen, DW; Callender, R; Desamero, R; Gulotta, M; Qiu, L; Rösgen, J | 1 |
| Lee, MJ; Lin, HM; Venkatesu, P | 1 |
| Alonso, DO; Beck, DA; Bennion, BJ; Daggett, V | 1 |
| Rau, DC; Stanley, C | 1 |
| Krywka, C; Paulus, M; Royer, C; Sternemann, C; Tolan, M; Winter, R | 1 |
| Georgescauld, F; Lacombe, ML; Lascu, I; Mocan, I | 1 |
| Bryan, MA; Sharp, KA; Vanderkooi, JM; Zelent, B | 1 |
| Chew, SF; Kajimura, M; McClelland, GB; Walsh, PJ; Wood, CM | 1 |
| Bruździak, P; Panuszko, A; Stangret, J; Wyrzykowski, D; Zielkiewicz, J | 1 |
| Bowron, D; Koch, MH; Meersman, F; Soper, AK | 2 |
| Agard, DA; Bolen, DW; Krukenberg, KA; Rosgen, J; Street, TO | 1 |
| Fan, Y; Gao, YQ; Wei, H | 1 |
| Gao, YQ; Yang, L | 1 |
| Bolen, DW; Holthauzen, LM; Rösgen, J | 1 |
| Bolen, DW; Hu, CY; Kokubo, H; Lynch, GC; Pettitt, BM | 1 |
| Kuffel, A; Zielkiewicz, J | 1 |
| Hu, CY; Kokubo, H; Pettitt, BM | 1 |
| Heisler, IA; Mazur, K; Meech, SR | 1 |
| Graziano, G | 1 |
| Nase, J; Paulus, M; Sahle, CJ; Schroer, MA; Tolan, M; Wieland, DC; Winter, R; Zhai, Y | 1 |
| Jackson-Atogi, R; Rösgen, J | 1 |
| Hatori, K; Kumemoto, R; Shibayama, T; Yusa, K | 1 |
| Deniz, AA; Ferreon, AC; Gambin, Y; Moosa, MM | 1 |
| Gai, F; Pazos, IM | 1 |
| Canchi, DR; García, AE | 1 |
| Minton, AP; Wu, D | 1 |
| Erwin, N; Estel, K; Seeliger, J; Winter, R | 1 |
| Paul, S; Sarma, R | 1 |
| Berne, BJ; Mondal, J; Stirnemann, G | 1 |
| Dong, Y; Tu, X; Yu, J; Zhang, X | 1 |
| Myers, JK; Silvers, TR | 1 |
| Gai, F; Ma, J; Pazos, IM | 1 |
| Burke, T; Coumoundouros, C; Culham, DE; Deutch, CE; Ellinger, J; Kerr, CH; Murdock, L; Plater, SM; To, E; Wood, JM; Wright, G | 1 |
| Bakker, HJ; Bonn, M; Hunger, J; Mazur, K; Ottosson, N | 1 |
| Das Mahanta, D; Kumar Mitra, R; Samanta, N | 1 |
| Rosin, C; Schummel, PH; Winter, R | 1 |
| Rösgen, J | 1 |
| Feinstein, SC; LaPointe, NE; Larini, L; Levine, ZA; Shea, JE | 1 |
| Barnett, D; Currie, S; MacCormack, T; MacLellan, RJ; Tunnah, L; Wright, PA | 1 |
| Berne, BJ; Halverson, D; Li, IT; Mondal, J; Stirnemann, G; Walker, GC | 1 |
| Ganguly, P; Hajari, T; Shea, JE; van der Vegt, NF | 1 |
| Luong, TQ; Winter, R | 1 |
| DeOreo, P; Dobre, MA; Hai, X; Hostetter, TH; Landeras, V; Meyer, TW | 1 |
| Coughlin, DJ; Gezzi, NL; Long, GM; Modi, PM; Woluko, KN | 1 |
| Borgohain, G; Paul, S | 1 |
| Garringer, M; Qasim, MA | 1 |
| Li, W; Mu, Y; Yang, Y | 1 |
| Haag, A; Kalbitzer, HR; Kremer, W; Schummel, PH; Winter, R | 1 |
| Hong, J; Xiong, S | 1 |
| Gao, M; Schummel, PH; Winter, R | 1 |
| Guseman, AJ; Pielak, GJ | 1 |
| Arns, L; Gao, M; Winter, R | 1 |
| Anikeenko, AV; Geiger, A; Medvedev, NN; Smolin, N; Voloshin, VP; Winter, R | 1 |
| Anders, C; Erwin, N; Patra, S; Winter, R | 1 |
| Al-Ayoubi, SR; Golub, M; Peters, J; Schummel, PH; Winter, R | 1 |
| Martínez, L; Shimizu, S | 1 |
| Boserman, P; Ganguly, P; Shea, JE; van der Vegt, NFA | 1 |
| Cho, M; Kundu, A; Verma, PK | 1 |
| Anderson, WG; Brandt, C; Evans, AN; Lambert, FN; Treberg, JR | 1 |
| Grover, A; Kumari, A; Rajput, R; Shrivastava, N; Somvanshi, P | 1 |
| Canales, R; Held, C; Luong, TQ; Sadowski, G; Verevkin, SP; Wangler, A; Winter, R; Zaitsau, DH | 1 |
| Jaworek, MW; Schuabb, V; Winter, R | 1 |
| Gupta, A; Netz, RR; Pham, QD; Schlaich, A; Schneck, E; Sparr, E; Wolde-Kidan, A | 1 |
| Bethea, J; Boland, C; Boutwell, L; Cauley, J; Hammer, NI; Magers, DH; Prather, JC; Smith, SA; Verville, GA; Warren, KE; Zetterholm, SG | 1 |
| Högg, J; Jaworek, MW; Rosin, C; Schummel, PH; Winter, R | 1 |
| Chi, MC; Lan, YG; Lin, LL; Lin, MG; Lo, HF; Wang, TF | 1 |
| Kiesel, I; Knop, JM; Oliva, R; Patra, S; Schuabb, V; Winter, R | 1 |
| Ichiye, T; Teng, X | 2 |
| Anders, C; Arns, L; Knop, JM; Patra, S; Winter, R | 1 |
| Geiger, A; Medvedev, NN; Smolin, N; Voloshin, V; Winter, R | 1 |
| Anand, DV; Mu, Y; Shikhar, S; Xia, K | 1 |
| Held, C; Knierbein, M; Luong, TQ; Sadowski, G; Wangler, A; Winter, R | 1 |
| Bartoszewicz, M; Giebułtowicz, J; Kasprowicz, K; Korytowska, N; Ratkowski, W; Renke, M; Rita-Tkachenko, P; Wołyniec, W; Zorena, K | 1 |
| Ganguly, P; Heyda, J; Polák, J; Shea, JE; van der Vegt, NFA | 1 |
| Timson, DJ | 1 |
| Anand, DV; Meng, Z; Mu, Y; Xia, K | 1 |
| Folberth, A; Heyda, J; Polák, J; van der Vegt, NFA | 1 |
| Herrmann, C; Schnatwinkel, J | 1 |
| Oprzeska-Zingrebe, EA; Smiatek, J | 1 |
| André, C; Bennis, Y; Bodeau, S; Choukroun, G; Kamel, S; Lemaire-Hurtel, AS; Liabeuf, S; Masmoudi, K | 1 |
| Daschakraborty, S; Maiti, A | 2 |
| Biernacki, KA; Bruździak, P; Demkowicz, S; Jacek, K; Kuffel, A; Panuszko, A; Pieloszczyk, M; Stangret, J | 1 |
| Dixit, M; Hajari, T; Yadav, HOS | 1 |
| Bhat, MY; Dar, TA; Mir, IA; Singh, LR; Ul Hussain, M | 1 |
| Bakhshi, R; Kumari, K; Singh, K; Singh, KS; Singh, LR | 1 |
| Hoang, HN; Housaindokht, MR; Matsuda, T; Monhemi, H; Standley, DM | 1 |
| Baker, DL; Dougan, L; Laurent, H; Nasralla, M; Ries, ME | 1 |
| Harries, D; Shakhman, Y; Shumilin, I | 1 |
| Boob, MM; Gruebele, M; Pogorelov, TV; Sukenik, S | 1 |
| Funabara, D; Ito, H; Kanoh, S; Noma, T; Tsureyama, M | 1 |
| Arsiccio, A; Bowers, MT; Buratto, SK; Ganguly, P; Liu, X; Shea, JE | 1 |
6 review(s) available for urea and trimethyloxamine
| Article | Year |
|---|---|
The influence of feeding and fasting on plasma metabolites in the dogfish shark (Squalus acanthias).
Topics: 3-Hydroxybutyric Acid; Amino Acids; Ammonia; Animals; Blood Glucose; Dogfish; Eating; Energy Metabolism; Fasting; Fatty Acids, Nonesterified; Feeding Behavior; Methylamines; Osmolar Concentration; Postprandial Period; Predatory Behavior; Time Factors; Urea | 2010 |
Cosolvent effects on protein stability.
Topics: Animals; Excipients; Humans; Methylamines; Molecular Dynamics Simulation; Protein Denaturation; Protein Stability; Proteins; Solvents; Urea; Water | 2013 |
Single-molecule insights into the temperature and pressure dependent conformational dynamics of nucleic acids in the presence of crowders and osmolytes.
Topics: Chlorohydrins; DNA; Fluorescence Resonance Energy Transfer; Glycine; Humans; Methylamines; Nucleic Acid Conformation; Pressure; RNA; Sucrose; Temperature; Urea | 2019 |
Protein Stability in TMAO and Mixed Urea-TMAO Solutions.
Topics: Methylamines; Protein Stability; Solutions; Urea; Water | 2020 |
The roles and applications of chaotropes and kosmotropes in industrial fermentation processes.
Topics: Alcohols; Amino Acids, Diamino; Bacillus subtilis; Biofuels; Bioreactors; Butanols; Ethanol; Fermentation; Genes, Bacterial; Genes, Fungal; Glycerol; Methylamines; Protein Structure, Secondary; Saccharomyces cerevisiae; Sulfides; Urea; Water; Yeasts; Zymomonas | 2020 |
TMAO to the rescue of pathogenic protein variants.
Topics: Humans; Methylamines; Mutant Proteins; Proteins; Urea | 2022 |
137 other study(ies) available for urea and trimethyloxamine
| Article | Year |
|---|---|
Efflux and accumulation of amino nitrogen in relation to the volume of rat renal inner medullary cells exposed to media of variable osmolality.
Topics: Amines; Aminoisobutyric Acids; Animals; Biological Transport; Egtazic Acid; Female; Humans; In Vitro Techniques; Kidney Medulla; Meglumine; Methylamines; Osmolar Concentration; Rats; Rats, Inbred Strains; Sodium Chloride; Trifluoperazine; Urea; Water | 1992 |
Purification and properties of glutamine synthetase from liver of Squalus acanthias.
Topics: Animals; Chlorides; Chromatography, Gel; Dogfish; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutamate-Ammonia Ligase; Kinetics; Methylamines; Mitochondria, Liver; Molecular Weight; Sharks; Urea | 1985 |
Effects of urea and trimethylamine-N-oxide on enzyme activity and stability.
Topics: Alcohol Dehydrogenase; Argininosuccinate Lyase; Catalase; Enzyme Inhibitors; Enzyme Stability; Hot Temperature; Kinetics; Lyases; Methylamines; Urea; Xanthine Oxidase | 1987 |
Effects of urea, trimethylamine oxide, and osmolality on respiration and citrulline synthesis by isolated hepatic mitochondria from Squalus acanthias.
Topics: Animals; Citrulline; Dogfish; Kinetics; Methylamines; Mitochondria, Liver; Osmolar Concentration; Oxygen Consumption; Sharks; Urea | 1986 |
TMAO (trimethylamine oxide)-independence of oxygen affinity and its urea and ATP sensitivities in an elasmobranch hemoglobin.
Topics: Adenosine Triphosphate; Animals; Dogfish; Hemoglobins; Methylamines; Oxygen; Oxyhemoglobins; Sharks; Urea | 1983 |
Purification and properties of the glutamine- and N-acetyl-L-glutamate-dependent carbamoyl phosphate synthetase from liver of Squalus acanthias.
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Dogfish; Kinetics; Ligases; Liver; Methylamines; Nitrogen Oxides; Urea | 1981 |
Why do some organisms use a urea-methylamine mixture as osmolyte? Thermodynamic compensation of urea and trimethylamine N-oxide interactions with protein.
Topics: Methylamines; Models, Chemical; Osmolar Concentration; Protein Denaturation; Ribonuclease T1; Solvents; Thermodynamics; Urea; Water; Water-Electrolyte Balance | 1994 |
Interactions of the regulatory ligands Mg2+ and MgATP2- with the renal plasma membrane Ca(2+)-ATPase: effects of osmolytes that stabilize or destabilize protein structure.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Calcium-Transporting ATPases; Cell Membrane; Drug Interactions; Enzyme Activation; In Vitro Techniques; Kidney Tubules, Proximal; Ligands; Magnesium; Methylamines; Oxidants; Rabbits; Sucrose; Urea | 1993 |
Do Australian desert frogs co-accumulate counteracting solutes with urea during aestivation?
Topics: Animals; Anura; Australia; Betaine; Body Fluids; Chromatography, High Pressure Liquid; Estivation; Glycerylphosphorylcholine; Inositol; Methylamines; Muscles; Osmolar Concentration; Polymers; Sarcosine; Urea | 1996 |
A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation.
Topics: Amino Acids; Animals; Diketopiperazines; Elasmobranchii; Methylamines; Oxidants; Piperazines; Protein Conformation; Protein Denaturation; Solubility; Temperature; Thermodynamics; Urea; Water-Electrolyte Balance | 1997 |
Natural osmolyte trimethylamine N-oxide stimulates tubulin polymerization and reverses urea inhibition.
Topics: Animals; Cold Temperature; Methylamines; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Osmolar Concentration; Polymers; Rats; Tubulin; Urea | 1997 |
Urea and methylamines have similar effects on aldose reductase activity.
Topics: Aldehyde Reductase; Animals; Betaine; Enzyme Inhibitors; Glycerylphosphorylcholine; Kidney Medulla; Kinetics; Lens, Crystalline; Methylamines; Rats; Recombinant Proteins; Urea | 1997 |
Effects of glycine betaine and glycerophosphocholine on thermal stability of ribonuclease.
Topics: Animals; Betaine; Cattle; Drug Combinations; Drug Stability; Glycerylphosphorylcholine; Hot Temperature; Methylamines; Ribonuclease, Pancreatic; Urea | 1998 |
Time-dependent effects of trimethylamine-N-oxide/urea on lactate dehydrogenase activity: an unexplored dimension of the adaptation paradigm.
Topics: Animals; Kinetics; L-Lactate Dehydrogenase; Macromolecular Substances; Methylamines; Muscle, Skeletal; Oxidants; Rabbits; Time Factors; Urea | 1998 |
Trimethylamine-N-oxide counteracts urea effects on rabbit muscle lactate dehydrogenase function: a test of the counteraction hypothesis.
Topics: Animals; Kinetics; L-Lactate Dehydrogenase; Methylamines; Models, Chemical; Muscle, Skeletal; Oxidants; Rabbits; Urea | 1998 |
Effects of urea and trimethylamine N-oxide on fluidity of liposomes and membranes of an elasmobranch.
Topics: Animals; Erythrocyte Membrane; Female; Fluorescence Polarization; Liposomes; Male; Membrane Fluidity; Methylamines; Skates, Fish; Temperature; Urea | 1999 |
Novel cardiac protective effects of urea: from shark to rat.
Topics: Animals; Dogfish; Electrolysis; Female; Heart; In Vitro Techniques; Male; Methylamines; Myocardial Reperfusion Injury; Myocardium; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Species Specificity; Urea; Ventricular Function, Left | 1999 |
Microscopic stability of cold shock protein A examined by NMR native state hydrogen exchange as a function of urea and trimethylamine N-oxide.
Topics: Bacterial Proteins; Circular Dichroism; Drug Stability; Hydrogen; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylamines; Models, Molecular; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Thermodynamics; Urea | 2000 |
31P and 1H NMR studies of the effect of the counteracting osmolyte trimethylamine-N-oxide on interactions of urea with ribonuclease A.
Topics: Animals; Cattle; Hydrogen; Methylamines; Nuclear Magnetic Resonance, Biomolecular; Oxidants; Phosphorus; Poly U; Protein Conformation; Ribonuclease, Pancreatic; Urea | 2000 |
Functional protection of human haemoglobin against protein dissociation.
Topics: Adult; Erythrocytes; Hemoglobins; Humans; Methylamines; Models, Theoretical; Oxidants; Oxygen; Protein Binding; Protein Denaturation; Proteins; Urea | 2000 |
Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism.
Topics: Anilino Naphthalenesulfonates; Animals; Anions; Benzothiazoles; Cattle; Chemistry, Physical; Excipients; Fluorescent Dyes; Hydrogen-Ion Concentration; Insulin; Kinetics; Methylamines; Models, Chemical; Osmolar Concentration; Protein Denaturation; Salts; Sonication; Sucrose; Surface Properties; Thiazoles; Urea | 2001 |
Effect of salinity on flavin-containing monooxygenase expression and activity in rainbow trout (Oncorhynchus mykiss).
Topics: Adaptation, Physiological; Age Factors; Animals; Fresh Water; Gills; Intestines; Kidney; Liver; Methylamines; Myocardium; Oncorhynchus mykiss; Oxygenases; Seawater; Urea; Water-Electrolyte Balance | 2001 |
Volume-activated trimethylamine oxide efflux in red blood cells of spiny dogfish (Squalus acanthias).
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Ammonium Chloride; Animals; Cell Size; Dogfish; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme Precursors; Erythrocytes; Ethylene Glycol; Hypotonic Solutions; Intracellular Signaling Peptides and Proteins; Ion Transport; Methylamines; Niflumic Acid; Osmolar Concentration; Protein-Tyrosine Kinases; Quinine; src-Family Kinases; Syk Kinase; Taurine; Urea | 2001 |
Near infra-red spectra of urea with glycine betaine or trimethylamine N-oxide are additive.
Topics: Betaine; Hydrogen Bonding; Methylamines; Solutions; Spectroscopy, Near-Infrared; Thermodynamics; Urea | 2001 |
The molecular mechanism of stabilization of proteins by TMAO and its ability to counteract the effects of urea.
Topics: Calorimetry; Hydrogen Bonding; Methylamines; Proteins; Solutions; Thermodynamics; Urea; Water | 2002 |
The freeze-avoidance response of smelt Osmerus mordax: initiation and subsequent suppression of glycerol, trimethylamine oxide and urea accumulation.
Topics: Acclimatization; Animals; Body Temperature; Freezing; Glycerol; Liver; Methylamines; Osmolar Concentration; Salmoniformes; Seasons; Temperature; Urea | 2002 |
Osmolyte effects on helix formation in peptides and the stability of coiled-coils.
Topics: Alanine; Amino Acid Sequence; Circular Dichroism; Dimerization; DNA-Binding Proteins; Leucine Zippers; Methylamines; Molecular Sequence Data; Osmolar Concentration; Protein Denaturation; Protein Folding; Protein Kinases; Protein Structure, Secondary; Saccharomyces cerevisiae Proteins; Trifluoroethanol; Urea | 2002 |
Counteracting effects of urea and methylamines in function and structure of skeletal muscle myosin.
Topics: Adenosine Triphosphatases; Animals; Betaine; Fluorescence; Methylamines; Protein Conformation; Protein Structure, Tertiary; Skeletal Muscle Myosins; Urea | 2002 |
Trimethylamine N-oxide stabilizes RNA tertiary structure and attenuates the denaturating effects of urea.
Topics: Escherichia coli; Methylamines; Nucleic Acid Conformation; RNA, Bacterial; RNA, Transfer, Met; Thermodynamics; Urea | 2003 |
Hydrogen exchange kinetics of RNase A and the urea:TMAO paradigm.
Topics: Adaptation, Physiological; Binding Sites; Deuterium; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Methylamines; Protein Denaturation; Ribonuclease, Pancreatic; Thermodynamics; Urea | 2003 |
Measuring the stability of partly folded proteins using TMAO.
Topics: Methylamines; Osmolar Concentration; Oxidants; Protein Denaturation; Protein Folding; Proteins; Solvents; Thermodynamics; Urea | 2003 |
Protein stability in mixed solvents: a balance of contact interaction and excluded volume.
Topics: Algorithms; Binding Sites; Complex Mixtures; Computer Simulation; Databases, Protein; Guanidine; Methylamines; Models, Chemical; Models, Molecular; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Proteins; Solvents; Sucrose; Surface Properties; Urea; Water | 2003 |
Glutamate counteracts the denaturing effect of urea through its effect on the denatured state.
Topics: Amino Acyl-tRNA Synthetases; Animals; Betaine; Carbonic Anhydrases; Cattle; Dose-Response Relationship, Drug; Escherichia coli; Glutamates; Glutamic Acid; Inositol; Kinetics; Methylamines; Oxidants; Potassium Chloride; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Sorbitol; Spectrophotometry; Temperature; Thermodynamics; Time Factors; Trypsin; Tubulin; Urea | 2003 |
Osmolyte effects on kinetics of FKBP12 C22A folding coupled with prolyl isomerization.
Topics: Dose-Response Relationship, Drug; Escherichia coli; Humans; Kinetics; Methylamines; Models, Molecular; Oxidants; Peptidylprolyl Isomerase; Protein Denaturation; Protein Folding; Recombinant Proteins; Tacrolimus Binding Protein 1A; Thermodynamics; Time Factors; Urea | 2003 |
Regulation of a renal urea transporter with reduced salinity in a marine elasmobranch, Raja erinacea.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Blotting, Northern; DNA Primers; DNA, Complementary; Down-Regulation; Membrane Transport Proteins; Methylamines; Molecular Sequence Data; New Brunswick; Osmolar Concentration; Reverse Transcriptase Polymerase Chain Reaction; Seawater; Sequence Alignment; Sequence Analysis, DNA; Skates, Fish; Urea; Urea Transporters | 2003 |
Activation of halophilic nucleoside diphosphate kinase by a non-ionic osmolyte, trimethylamine N-oxide.
Topics: Circular Dichroism; Enzyme Activation; Halobacterium salinarum; Hot Temperature; Hydrogen-Ion Concentration; Methylamines; Nucleoside-Diphosphate Kinase; Potassium Chloride; Protein Conformation; Protein Denaturation; Protein Folding; Sodium Chloride; Time Factors; Urea | 2003 |
Haemoglobin function and respiratory status of the Port Jackson shark, Heterodontus portusjacksoni, in response to lowered salinity.
Topics: Acclimatization; Animals; Body Weight; Carbon Dioxide; Cardiac Output; Erythrocytes; Hematocrit; Hemoglobins; Hydrogen-Ion Concentration; Lactic Acid; Methylamines; Oxygen; Oxygen Consumption; Partial Pressure; Pulmonary Ventilation; Respiratory Mechanics; Respiratory Physiological Phenomena; Seawater; Sharks; Sodium Chloride; Urea | 2004 |
Counteraction of urea-induced protein denaturation by trimethylamine N-oxide: a chemical chaperone at atomic resolution.
Topics: Methylamines; Models, Molecular; Protein Denaturation; Solvents; Urea | 2004 |
Dogmas and controversies in the handling of nitrogenous wastes: osmoregulation during early embryonic development in the marine little skate Raja erinacea; response to changes in external salinity.
Topics: Analysis of Variance; Animals; Arginase; Carbon-Nitrogen Ligases; Colorimetry; Embryo, Nonmammalian; Glutamate-Ammonia Ligase; Methylamines; Ornithine Carbamoyltransferase; Seawater; Skates, Fish; Spectrophotometry; Time Factors; Urea; Water-Electrolyte Balance | 2004 |
Osmolytes induce structure in an early intermediate on the folding pathway of barstar.
Topics: Bacterial Proteins; Circular Dichroism; Dose-Response Relationship, Drug; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methylamines; Models, Chemical; Plasmids; Protein Conformation; Protein Denaturation; Protein Folding; Sarcosine; Spectrophotometry; Temperature; Thermodynamics; Time Factors; Ultraviolet Rays; Urea | 2004 |
A comparison of the counteracting effects of glycine betaine and TMAO on the activity of RNase A in aqueous urea solution.
Topics: Animals; Betaine; Catalysis; Cattle; Magnetic Resonance Spectroscopy; Methylamines; Molecular Structure; Ribonuclease, Pancreatic; RNA; Solutions; Urea | 2005 |
A natural osmolyte trimethylamine N-oxide promotes assembly and bundling of the bacterial cell division protein, FtsZ and counteracts the denaturing effects of urea.
Topics: Anilino Naphthalenesulfonates; Bacterial Proteins; Cell Division; Cytoskeletal Proteins; Fluorescent Dyes; Glutamic Acid; GTP Phosphohydrolases; Guanidine; Methylamines; Parasympathomimetics; Protein Conformation; Protein Denaturation; Protein Folding; Urea | 2005 |
Effects of urea and trimethylamine-N-oxide (TMAO) on the interactions of lysozyme in solution.
Topics: Animals; Biophysics; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Methylamines; Models, Statistical; Multiprotein Complexes; Muramidase; Potassium Chloride; Protein Denaturation; Scattering, Radiation; Solutions; Synchrotrons; Temperature; Thermodynamics; Time Factors; Urea; Water; X-Rays | 2005 |
Alkaline tide and nitrogen conservation after feeding in an elasmobranch (Squalus acanthias).
Topics: Acid-Base Equilibrium; Ammonia; Analysis of Variance; Animals; Bicarbonates; Blood Glucose; British Columbia; Carbon Dioxide; Hydrogen-Ion Concentration; Methylamines; Nitrogen; Oxygen; Postprandial Period; Squalus acanthias; Time Factors; Urea; Water-Electrolyte Balance | 2005 |
Lactate dehydrogenase undergoes a substantial structural change to bind its substrate.
Topics: Animals; Binding Sites; Kinetics; L-Lactate Dehydrogenase; Methylamines; Models, Molecular; Myocardium; NAD; Protein Binding; Protein Conformation; Solvents; Substrate Specificity; Swine; Temperature; Urea | 2007 |
Effects of osmolytes on RNA secondary and tertiary structure stabilities and RNA-Mg2+ interactions.
Topics: Base Sequence; Betaine; Cations, Divalent; Ethylene Glycol; Magnesium; Methanol; Methylamines; Molecular Sequence Data; Nucleic Acid Conformation; Osmotic Pressure; Proline; RNA; RNA Stability; Sucrose; Sugar Alcohols; Thermodynamics; Urea | 2007 |
The influence of urea and trimethylamine-N-oxide on hydrophobic interactions.
Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Models, Chemical; Pentanes; Protein Denaturation; Protein Folding; Solutions; Urea | 2007 |
Effects of osmolytes on hexokinase kinetics combined with macromolecular crowding: test of the osmolyte compatibility hypothesis towards crowded systems.
Topics: Betaine; Buffers; Catalysis; Fungal Proteins; Glycerol; Hexokinase; Kinetics; Methylamines; Models, Chemical; Osmotic Pressure; Protein Binding; Serum Albumin, Bovine; Sodium Chloride; Urea; Water | 2007 |
Effects of cell volume regulating osmolytes on glycerol 3-phosphate binding to triosephosphate isomerase.
Topics: Algorithms; Cell Size; Dose-Response Relationship, Drug; Enzyme Activation; Glycerophosphates; Kinetics; Methylamines; Models, Chemical; Models, Molecular; Osmosis; Protein Binding; Protein Denaturation; Protein Folding; Sodium Chloride; Substrate Specificity; Thermodynamics; Triose-Phosphate Isomerase; Urea | 2007 |
Trimethylamine N-oxide counteracts the denaturing effects of urea or GdnHCl on protein denatured state.
Topics: Dipeptides; Guanidine; Methylamines; Protein Conformation; Protein Denaturation; Protein Folding; Urea | 2007 |
Simulations of macromolecules in protective and denaturing osmolytes: properties of mixed solvent systems and their effects on water and protein structure and dynamics.
Topics: Computer Simulation; Hydrogen Bonding; Methylamines; Models, Molecular; Osmotic Pressure; Peptides; Plant Proteins; Protein Denaturation; Proteins; Solvents; Urea; Water | 2007 |
Measuring the interaction of urea and protein-stabilizing osmolytes with the nonpolar surface of hydroxypropylcellulose.
Topics: Algorithms; Betaine; Cellulose; Glycerol; Hydrophobic and Hydrophilic Interactions; Methylamines; Models, Chemical; Organic Chemicals; Osmotic Pressure; Proteins; Scattering, Radiation; Sorbitol; Temperature; Thermodynamics; Urea; X-Rays | 2008 |
Hydrophobic interactions in urea-trimethylamine-N-oxide solutions.
Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Pentanes; Solutions; Surface-Active Agents; Temperature; Urea | 2008 |
Effect of osmolytes on pressure-induced unfolding of proteins: a high-pressure SAXS study.
Topics: Glycerol; Methylamines; Micrococcal Nuclease; Pressure; Protein Conformation; Protein Denaturation; Protein Stability; Scattering, Small Angle; Solutions; Temperature; Urea; X-Ray Diffraction | 2008 |
Rescue of the neuroblastoma mutant of the human nucleoside diphosphate kinase A/nm23-H1 by the natural osmolyte trimethylamine-N-oxide.
Topics: Dose-Response Relationship, Drug; Humans; Kinetics; Methylamines; Neoplasm Proteins; Neuroblastoma; NM23 Nucleoside Diphosphate Kinases; Point Mutation; Protein Folding; Urea | 2009 |
Influence of surface groups of proteins on water studied by freezing/thawing hysteresis and infrared spectroscopy.
Topics: Ammonium Chloride; Animals; Antifreeze Proteins; Cattle; Cytochromes c; Flounder; Freezing; Glutamic Acid; Guanidine; Methanol; Methylamines; Peptides; Polylysine; Proteins; Serum Albumin, Bovine; Sodium Acetate; Spectrophotometry, Infrared; Temperature; Transition Temperature; Urea; Water | 2009 |
Effects of urea and trimethylamine-N-oxide on the properties of water and the secondary structure of hen egg white lysozyme.
Topics: Animals; Calorimetry; Chickens; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Muramidase; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Urea; Water | 2009 |
Counteraction of urea by trimethylamine N-oxide is due to direct interaction.
Topics: Biophysics; Computer Simulation; Hydrogen; Hydrogen Bonding; Hydrogen-Ion Concentration; Methylamines; Models, Chemical; Neutrons; Oxygen; Peptides; Scattering, Radiation; Solutions; Solvents; Urea; Water | 2009 |
Osmolyte-induced conformational changes in the Hsp90 molecular chaperone.
Topics: Adenylyl Imidodiphosphate; Betaine; Escherichia coli Proteins; Glycerol; HSP90 Heat-Shock Proteins; Methylamines; Models, Molecular; Osmosis; Protein Conformation; Sarcosine; Scattering, Small Angle; Urea; X-Ray Diffraction | 2010 |
Effects of urea, tetramethyl urea, and trimethylamine N-oxide on aqueous solution structure and solvation of protein backbones: a molecular dynamics simulation study.
Topics: Hydrogen Bonding; Methylamines; Methylurea Compounds; Molecular Dynamics Simulation; Peptides; Protein Denaturation; Urea; Water | 2010 |
Effects of cosolvents on the hydration of carbon nanotubes.
Topics: Hydrogen Bonding; Methanol; Methylamines; Molecular Dynamics Simulation; Nanotubes, Carbon; Particle Size; Solvents; Static Electricity; Surface Properties; Urea; Water | 2010 |
Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes.
Topics: Animals; Ankyrin Repeat; Drosophila Proteins; Gene Deletion; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Methylamines; Osmosis; Peptide Fragments; Protein Denaturation; Protein Stability; Protein Structure, Tertiary; Protein Transport; Receptors, Notch; Sarcosine; Thermodynamics; Urea; Water | 2010 |
Backbone additivity in the transfer model of protein solvation.
Topics: Glycine; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Oligopeptides; Osmolar Concentration; Protein Conformation; Protein Folding; Proteins; Solvents; Static Electricity; Thermodynamics; Urea; Water | 2010 |
The hydrogen bond network structure within the hydration shell around simple osmolytes: urea, tetramethylurea, and trimethylamine-N-oxide, investigated using both a fixed charge and a polarizable water model.
Topics: Hydrogen Bonding; Methylamines; Methylurea Compounds; Molecular Dynamics Simulation; Osmosis; Probability; Solvents; Urea; Water | 2010 |
Peptide conformational preferences in osmolyte solutions: transfer free energies of decaalanine.
Topics: Alanine; Methylamines; Molecular Dynamics Simulation; Oligopeptides; Osmosis; Protein Denaturation; Protein Structure, Secondary; Solutions; Thermodynamics; Urea; Water | 2011 |
THz spectra and dynamics of aqueous solutions studied by the ultrafast optical Kerr effect.
Topics: Formamides; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Methylamines; Methylurea Compounds; Models, Molecular; Quantum Theory; Solutions; Terahertz Spectroscopy; Urea; Water | 2011 |
An X-ray and neutron scattering study of the equilibrium between trimethylamine N-oxide and urea in aqueous solution.
Topics: Methylamines; Neutron Diffraction; Oxides; Protein Binding; Proteins; Scattering, Radiation; Scattering, Small Angle; Urea; Water; X-Ray Diffraction | 2011 |
How does trimethylamine N-oxide counteract the denaturing activity of urea?
Topics: Methylamines; Protein Conformation; Protein Denaturation; Proteins; Surface Properties; Thermodynamics; Urea | 2011 |
Exploring the piezophilic behavior of natural cosolvent mixtures.
Topics: Animals; Hydrostatic Pressure; Methylamines; Models, Molecular; Osmolar Concentration; Proteins; Scattering, Small Angle; Solvents; Urea; X-Ray Diffraction | 2011 |
Volume exclusion and H-bonding dominate the thermodynamics and solvation of trimethylamine-N-oxide in aqueous urea.
Topics: Hydrogen Bonding; Methylamines; Solubility; Thermodynamics; Urea; Water | 2012 |
Trimethylamine N-oxide suppresses the activity of the actomyosin motor.
Topics: Actin Cytoskeleton; Actomyosin; Adenosine Triphosphatases; Animals; Dose-Response Relationship, Drug; Down-Regulation; In Vitro Techniques; Methylamines; Movement; Multiprotein Complexes; Myosin Subfragments; Osmolar Concentration; Protein Stability; Rabbits; Urea | 2012 |
Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape.
Topics: alpha-Synuclein; Fluorescence Resonance Energy Transfer; Methylamines; Molecular Chaperones; Protein Conformation; Urea | 2012 |
Solute's perspective on how trimethylamine oxide, urea, and guanidine hydrochloride affect water's hydrogen bonding ability.
Topics: Guanidine; Hydrogen Bonding; Methylamines; Thermodynamics; Urea; Water | 2012 |
Compensating effects of urea and trimethylamine-N-oxide on the heteroassociation of α-chymotrypsin and soybean trypsin inhibitor.
Topics: Chymotrypsin; Fluorescence; Glycine max; Hydrogen-Ion Concentration; Methylamines; Thermodynamics; Trypsin Inhibitor, Kunitz Soybean; Urea | 2013 |
Cosolvent effects on the fibrillation reaction of human IAPP.
Topics: Amyloid; Betaine; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Methylamines; Protein Stability; Protein Structure, Secondary; Urea | 2013 |
Exploring the molecular mechanism of trimethylamine-N-oxide's ability to counteract the protein denaturing effects of urea.
Topics: Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Protein Denaturation; Proteins; Urea; Water | 2013 |
When does trimethylamine N-oxide fold a polymer chain and urea unfold it?
Topics: Methylamines; Molecular Dynamics Simulation; Polymers; Protein Denaturation; Protein Folding; Urea | 2013 |
Effects of environmental factors on MSP21-25 aggregation indicate the roles of hydrophobic and electrostatic interactions in the aggregation process.
Topics: Anilino Naphthalenesulfonates; Antigens, Protozoan; Benzothiazoles; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Methylamines; Peptide Fragments; Protein Multimerization; Protozoan Proteins; Sodium Dodecyl Sulfate; Static Electricity; Thiazoles; Urea | 2014 |
Osmolyte effects on the self-association of concanavalin A: testing theoretical models.
Topics: Betaine; Circular Dichroism; Concanavalin A; Dimerization; Hydrogen-Ion Concentration; Indicators and Reagents; Methylamines; Models, Molecular; Osmolar Concentration; Proline; Protein Interaction Domains and Motifs; Protein Stability; Sarcosine; Secondary Metabolism; Sorbitol; Sucrose; Thermodynamics; Titrimetry; Trehalose; Urea | 2013 |
Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO).
Topics: Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylamines; Microfilament Proteins; Mutation; Peptides; Protein Conformation; Protein Folding; Protein Stability; Protein Unfolding; Proteins; Spectroscopy, Fourier Transform Infrared; Urea; Water | 2014 |
Analysis of strains lacking known osmolyte accumulation mechanisms reveals contributions of osmolytes and transporters to protection against abiotic stress.
Topics: Betaine; Culture Media; Escherichia coli; Methylamines; Osmotic Pressure; Proline; Sodium Chloride; Stress, Physiological; Sulfonium Compounds; Temperature; Urea | 2014 |
Water-mediated interactions between trimethylamine-N-oxide and urea.
Topics: Dielectric Spectroscopy; Hydrogen Bonding; Methylamines; Models, Molecular; Urea; Water | 2015 |
Does urea alter the collective hydrogen-bond dynamics in water? A dielectric relaxation study in the terahertz-frequency region.
Topics: Electric Impedance; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Terahertz Spectroscopy; Urea; Water | 2014 |
Cosolvent and crowding effects on the polymerization kinetics of actin.
Topics: Actins; Dextrans; Kinetics; Methylamines; Polymerization; Protein Interaction Domains and Motifs; Proteins; Solvents; Time-Lapse Imaging; Urea | 2015 |
Synergy in protein-osmolyte mixtures.
Topics: Methylamines; Models, Statistical; Osmolar Concentration; Proteins; Surface Properties; Thermodynamics; Urea | 2015 |
Regulation and aggregation of intrinsically disordered peptides.
Topics: Humans; Methylamines; Molecular Dynamics Simulation; Peptides; Protein Aggregation, Pathological; Protein Structure, Secondary; tau Proteins; Urea | 2015 |
Chaperone roles for TMAO and HSP70 during hyposmotic stress in the spiny dogfish shark (Squalus acanthias).
Topics: Adaptation, Physiological; Animals; Fish Proteins; Gills; HSP70 Heat-Shock Proteins; Male; Methylamines; Muscles; Osmotic Pressure; Salinity; Seawater; Sodium-Potassium-Exchanging ATPase; Squalus acanthias; Time Factors; Urea | 2015 |
How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory.
Topics: Computer Simulation; Hydrophobic and Hydrophilic Interactions; Methylamines; Microscopy, Atomic Force; Molecular Dynamics Simulation; Normal Distribution; Polymers; Polystyrenes; Protein Binding; Protein Conformation; Protein Folding; Proteins; Software; Solvents; Stress, Mechanical; Thermodynamics; Urea; Water | 2015 |
Mutual Exclusion of Urea and Trimethylamine N-Oxide from Amino Acids in Mixed Solvent Environment.
Topics: Amino Acids; Methylamines; Molecular Dynamics Simulation; Solvents; Urea | 2015 |
Combined pressure and cosolvent effects on enzyme activity - a high-pressure stopped-flow kinetic study on α-chymotrypsin.
Topics: Biocatalysis; Chymotrypsin; Enzyme Activation; Hydrolysis; Kinetics; Methylamines; Peptides; Pressure; Solvents; Urea | 2015 |
Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients.
Topics: Adult; Biomarkers; Case-Control Studies; Creatinine; Female; Humans; Kidney Failure, Chronic; Male; Methylamines; Renal Dialysis; Urea | 2015 |
Elevated osmolytes in rainbow smelt: the effects of urea, glycerol and trimethylamine oxide on muscle contractile properties.
Topics: Animals; Cold Temperature; Cryoprotective Agents; Glycerol; Methylamines; Muscle Contraction; Muscle Fibers, Fast-Twitch; Osmeriformes; Urea | 2016 |
Model Dependency of TMAO's Counteracting Effect Against Action of Urea: Kast Model versus Osmotic Model of TMAO.
Topics: Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Osmosis; Static Electricity; Urea | 2016 |
Effect of Osmolytes and Guanidinium Chloride on the Enzymatic Properties of Bovine α-Chymotrypsin.
Topics: Animals; Betaine; Biocatalysis; Catalytic Domain; Cattle; Chymotrypsin; Guanidine; Kinetics; Methylamines; Peptides; Urea | 2016 |
Microscopic significance of hydrophobic residues in the protein-stabilizing effect of trimethylamine N-oxide (TMAO).
Topics: Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Methylamines; Molecular Conformation; Molecular Dynamics Simulation; Proteins; Urea | 2016 |
Cosolvent and Crowding Effects on the Temperature and Pressure Dependent Conformational Dynamics and Stability of Globular Actin.
Topics: Actins; Methylamines; Nuclear Magnetic Resonance, Biomolecular; Pressure; Protein Stability; Solvents; Spectrometry, Fluorescence; Temperature; Thermodynamics; Urea | 2016 |
TMAO-Protein Preferential Interaction Profile Determines TMAO's Conditional In Vivo Compatibility.
Topics: Amyloid beta-Peptides; Dose-Response Relationship, Drug; Drug Interactions; Hydrophobic and Hydrophilic Interactions; Methylamines; Osmosis; Peptide Fragments; Protein Binding; Protein Multimerization; Protein Stability; Protein Structure, Quaternary; Proteins; Substrate Specificity; Thermodynamics; Urea | 2016 |
Modulation of the Polymerization Kinetics of α/β-Tubulin by Osmolytes and Macromolecular Crowding.
Topics: Ficoll; Kinetics; Macromolecular Substances; Methylamines; Osmosis; Polymerization; Solvents; Sucrose; Tubulin; Urea | 2017 |
Cosolute and Crowding Effects on a Side-By-Side Protein Dimer.
Topics: Cytosol; Escherichia coli; Ficoll; Fluorine; Methylamines; Models, Molecular; Muramidase; Nuclear Magnetic Resonance, Biomolecular; Protein Multimerization; Protein Stability; Receptors, GABA-B; Serum Albumin, Bovine; Urea | 2017 |
Modulation of the Thermodynamic Signatures of an RNA Thermometer by Osmolytes and Salts.
Topics: Entropy; Methylamines; Nucleic Acid Conformation; Osmolar Concentration; RNA; RNA Folding; RNA Stability; Salts; Static Electricity; Temperature; Thermodynamics; Urea; Water | 2017 |
TMAO and urea in the hydration shell of the protein SNase.
Topics: Methylamines; Micrococcal Nuclease; Molecular Dynamics Simulation; Solvents; Temperature; Urea; Water | 2017 |
Osmolyte Effects on the Conformational Dynamics of a DNA Hairpin at Ambient and Extreme Environmental Conditions.
Topics: DNA; Fluorescence Resonance Energy Transfer; Hot Temperature; Methylamines; Nucleic Acid Conformation; Osmolar Concentration; Pressure; Thermodynamics; Urea | 2017 |
Influence of cosolvents, self-crowding, temperature and pressure on the sub-nanosecond dynamics and folding stability of lysozyme.
Topics: Hydrogen; Methylamines; Muramidase; Neutron Diffraction; Protein Folding; Temperature; Urea; Water | 2017 |
Molecular Interpretation of Preferential Interactions in Protein Solvation: A Solvent-Shell Perspective by Means of Minimum-Distance Distribution Functions.
Topics: Methylamines; Molecular Dynamics Simulation; Ribonuclease T1; Solvents; Thermodynamics; Urea | 2017 |
Trimethylamine N-oxide Counteracts Urea Denaturation by Inhibiting Protein-Urea Preferential Interaction.
Topics: Methylamines; Molecular Dynamics Simulation; Osmotic Pressure; Peptides; Protein Binding; Protein Denaturation; tau Proteins; Urea; Water | 2018 |
Effect of Osmolytes on the Conformational Behavior of a Macromolecule in a Cytoplasm-like Crowded Environment: A Femtosecond Mid-IR Pump-Probe Spectroscopy Study.
Topics: Ethers; Excipients; Glycine; Hydrogen Bonding; Methylamines; Molecular Conformation; Osmolar Concentration; Polyethylene Glycols; Protein Denaturation; Protein Stability; Sorbitol; Spectroscopy, Fourier Transform Infrared; Urea; Water | 2018 |
The physiological stress response of the Atlantic stingray (Hypanus sabinus) to aerial exposure.
Topics: 3-Hydroxybutyric Acid; Acidosis; Air; Animals; Blood Glucose; Homeostasis; Ketone Bodies; Lactic Acid; Male; Methylamines; Osmolar Concentration; Skates, Fish; Stress, Physiological; Urea | 2018 |
Synergistic approaches unraveling regulation and aggregation of intrinsically disordered β-amyloids implicated in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Intrinsically Disordered Proteins; Methylamines; Peptide Fragments; Protein Aggregation, Pathological; Urea | 2018 |
Co-solvent effects on reaction rate and reaction equilibrium of an enzymatic peptide hydrolysis.
Topics: Animals; Calcium Chloride; Cattle; Chymotrypsin; Dimethyl Sulfoxide; Hydrolysis; Kinetics; Methylamines; Phenylalanine; Sodium Chloride; Solvents; Thermodynamics; Urea; Water | 2018 |
Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils.
Topics: Amino Acid Sequence; Amyloid; Amyloidogenic Proteins; Catalysis; Ficoll; Kinetics; Methylamines; Molecular Dynamics Simulation; Pressure; Solvents; Spectroscopy, Fourier Transform Infrared; Temperature; Urea | 2018 |
Effects of Urea and TMAO on Lipid Self-Assembly under Osmotic Stress Conditions.
Topics: Calorimetry; Dimyristoylphosphatidylcholine; Magnetic Resonance Spectroscopy; Methylamines; Molecular Dynamics Simulation; Osmotic Pressure; Phosphatidylcholines; Urea; Water | 2018 |
Noncovalent Interactions between Trimethylamine N-Oxide (TMAO), Urea, and Water.
Topics: Hydrogen Bonding; Methylamines; Models, Chemical; Spectrum Analysis, Raman; Thermodynamics; Urea; Water | 2018 |
Exploring the influence of natural cosolvents on the free energy and conformational landscape of filamentous actin and microtubules.
Topics: Actins; Animals; Cattle; Methylamines; Microtubules; Pressure; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Stability; Protein Unfolding; Rabbits; Solvents; Thermodynamics; Transition Temperature; Tubulin; Urea | 2018 |
Protective Effect of Biological Osmolytes against Heat- and Chaotropic Agent-Induced Denaturation of
Topics: Bacillus licheniformis; Escherichia coli; gamma-Glutamyltransferase; Glycerol; Guanidine; Hot Temperature; Methylamines; Osmolar Concentration; Protein Denaturation; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Sorbitol; Spectrometry, Fluorescence; Sucrose; Urea | 2018 |
Exploring the effects of cosolutes and crowding on the volumetric and kinetic profile of the conformational dynamics of a poly dA loop DNA hairpin: a single-molecule FRET study.
Topics: Cations; DNA; Ficoll; Fluorescence Resonance Energy Transfer; Kinetics; Methylamines; Nucleic Acid Conformation; Poly A; Urea | 2019 |
Dynamical Effects of Trimethylamine N-Oxide on Aqueous Solutions of Urea.
Topics: Diffusion; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Solutions; Urea; Water | 2019 |
Dynamics of TMAO and urea in the hydration shell of the protein SNase.
Topics: Endodeoxyribonucleases; Methylamines; Molecular Dynamics Simulation; Protein Stability; Solvents; Urea; Water | 2019 |
Persistent homology analysis of osmolyte molecular aggregation and their hydrogen-bonding networks.
Topics: Entropy; Hydrogen; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Protein Aggregation, Pathological; Structural Homology, Protein; Urea | 2019 |
Combined co-solvent and pressure effect on kinetics of a peptide hydrolysis: an activity-based approach.
Topics: Chymotrypsin; Dimethyl Sulfoxide; Hydrolysis; Kinetics; Methylamines; Phenylalanine; Pressure; Solvents; Thermodynamics; Urea; Water | 2019 |
Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Albuminuria; Arginine; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Humans; Lipocalin-2; Lipocalins; Male; Methylamines; Middle Aged; Running; Urea; Uric Acid; Water | 2019 |
Dynamical Model for the Counteracting Effects of Trimethylamine
Topics: Hydrogen Bonding; Methylamines; Urea; Water | 2020 |
Weighted persistent homology for osmolyte molecular aggregation and hydrogen-bonding network analysis.
Topics: Entropy; Hydrogen Bonding; Methylamines; Models, Chemical; Molecular Dynamics Simulation; Molecular Structure; Protein Folding; Solutions; Urea | 2020 |
Pressure, Peptides, and a Piezolyte: Structural Analysis of the Effects of Pressure and Trimethylamine-
Topics: Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Peptides; Urea; Water | 2020 |
The interaction strength of an intrinsically disordered protein domain with its binding partner is little affected by very different cosolutes.
Topics: Betaine; CREB-Binding Protein; Entropy; Glycine; Humans; Intrinsically Disordered Proteins; Kinetics; Methylamines; Protein Binding; Protein Domains; Proto-Oncogene Proteins c-myb; Temperature; Urea | 2020 |
Interactions of a DNA G-quadruplex with TMAO and urea: a molecular dynamics study on co-solute compensation mechanisms.
Topics: DNA; G-Quadruplexes; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Thermodynamics; Urea; Water | 2021 |
Potential interactions between uraemic toxins and drugs: an application in kidney transplant recipients treated with calcineurin inhibitors.
Topics: Aged; Calcineurin Inhibitors; Cross-Sectional Studies; Cyclosporine; Humans; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Tacrolimus; Transplant Recipients; Urea; Uremic Toxins | 2022 |
How Do Urea and Trimethylamine
Topics: Dehydration; Humans; Lipids; Methylamines; Urea | 2021 |
Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions.
Topics: Chemical Phenomena; Glycine; Glycylglycine; Methylamines; Molecular Dynamics Simulation; Osmotic Pressure; Peptides; Solutions; Spectroscopy, Fourier Transform Infrared; Urea; Water | 2021 |
Can Urea and Trimethylamine-
Topics: Lipids; Methylamines; Solutions; Urea; Water | 2022 |
Hydrophobic association and solvation of neopentane in urea, TMAO and urea-TMAO solutions.
Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Molecular Dynamics Simulation; Pentanes; Solutions; Urea; Water | 2022 |
Urea ameliorates trimethylamine N-oxide-Induced aggregation of intrinsically disordered α-casein protein: the other side of the urea-methylamine counteraction.
Topics: Amyloid beta-Peptides; Caseins; HEK293 Cells; Humans; Intrinsically Disordered Proteins; Methylamines; Urea | 2023 |
The protein-stabilizing effects of TMAO in aqueous and non-aqueous conditions.
Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Proteins; Solvents; Urea; Water | 2022 |
A study of the interaction between TMAO and urea in water using NMR spectroscopy.
Topics: Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylamines; Urea; Water | 2022 |
Urea counteracts trimethylamine N-oxide (TMAO) compaction of lipid membranes by modifying van der Waals interactions.
Topics: Animals; Lipids; Methylamines; Nucleic Acids; Proteins; Urea | 2023 |
TMAO: Protecting proteins from feeling the heat.
Topics: Animals; Hot Temperature; Methylamines; Proteins; Urea; Water | 2023 |
Myosin light chain of shark fast skeletal muscle exhibits intrinsic urea-resistibility.
Topics: Animals; Muscle, Skeletal; Myosin Light Chains; Sharks; Urea | 2023 |
Effect of Cosolutes on the Aggregation of a Tau Fragment: A Combined Experimental and Simulation Approach.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Alzheimer Disease; Humans; Molecular Dynamics Simulation; tau Proteins; Urea | 2023 |