urea and trimethyloxamine

urea has been researched along with trimethyloxamine in 143 studies

Research

Studies (143)

TimeframeStudies, this research(%)All Research%
pre-19905 (3.50)18.7374
1990's12 (8.39)18.2507
2000's41 (28.67)29.6817
2010's65 (45.45)24.3611
2020's20 (13.99)2.80

Authors

AuthorsStudies
Law, RO1
Anderson, PM; Shankar, RA1
Fridovich, I; Mashino, T1
Anderson, PM2
Weber, RE1
Lin, TY; Timasheff, SN1
Caruso-Neves, C; Vieyra, A1
Guppy, M; Withers, PC1
Bolen, DW; Wang, A1
Sackett, DL1
Burg, MB; Peters, EM2
Baskakov, I; Bolen, DW1
Baskakov, I; Bolen, DW; Wang, A1
Ballantyne, JS; Barton, KN; Buhr, MM1
Aouffen, M; Mateescu, MA; Nadeau, R; Wang, R; Wang, X; Wu, L1
Alexandrescu, AT; Jaravine, VA; Rathgeb-Szabo, K1
Bedford, JJ; Leader, JP; Palmer, HR; Smith, RA1
Brittain, T1
Brange, J; Coats, A; Fink, AL; Frokjaer, S; Khurana, R; Nielsen, L; Uversky, VN; Vyas, S1
Larsen, BK; Schlenk, D1
Goldstein, L; Koomoa, DL; MacLean, AV; Musch, MW1
Galinski, EA; Lever, M; Randall, K1
Bennion, BJ; Daggett, V; Murphy, KP; Zou, Q1
Driedzic, WR; Ewart, KV; Richards, RC; Treberg, JR; Wilson, CE1
Celinski, SA; Scholtz, JM1
Ortiz-Costa, S; Sola-Penna, M; Sorenson, MM1
Gluick, TC; Yadav, S1
Bolen, DW; Qu, Y1
Barrick, D; Mello, CC1
Schellman, JA1
Banerjee, R; Bhattacharyya, A; Lahiri, S; Mandal, AK; Roy, S; Samaddar, S1
Bolen, DW; Rösgen, J; Russo, AT1
Ballantyne, JS; Morgan, RL; Wright, PA1
Arakawa, T; Ishibashi, M; Sakashita, K; Tokunaga, H; Tokunaga, M1
Cooper, AR; Morris, S1
Bennion, BJ; Daggett, V1
Steele, SL; Wright, PA; Yancey, PH1
Pradeep, L; Udgaonkar, JB1
Bedford, JJ; Leader, JP; Samuelsson, LM; Smith, RA1
Beuria, TK; Mukherjee, A; Panda, D; Santra, MK1
Koch, MH; Niebuhr, M1
Kajimura, M; Mommsen, TP; Walsh, PJ; Wood, CM1
Callender, R; Gulotta, M; Qiu, L1
Draper, DE; Lambert, D1
Patey, GN; Paul, S2
Olsen, SN; Ramløv, H; Westh, P1
Bolen, DW; Callender, R; Desamero, R; Gulotta, M; Qiu, L; Rösgen, J1
Lee, MJ; Lin, HM; Venkatesu, P1
Alonso, DO; Beck, DA; Bennion, BJ; Daggett, V1
Rau, DC; Stanley, C1
Krywka, C; Paulus, M; Royer, C; Sternemann, C; Tolan, M; Winter, R1
Georgescauld, F; Lacombe, ML; Lascu, I; Mocan, I1
Bryan, MA; Sharp, KA; Vanderkooi, JM; Zelent, B1
Chew, SF; Kajimura, M; McClelland, GB; Walsh, PJ; Wood, CM1
Bruździak, P; Panuszko, A; Stangret, J; Wyrzykowski, D; Zielkiewicz, J1
Bowron, D; Koch, MH; Meersman, F; Soper, AK2
Agard, DA; Bolen, DW; Krukenberg, KA; Rosgen, J; Street, TO1
Fan, Y; Gao, YQ; Wei, H1
Gao, YQ; Yang, L1
Bolen, DW; Holthauzen, LM; Rösgen, J1
Bolen, DW; Hu, CY; Kokubo, H; Lynch, GC; Pettitt, BM1
Kuffel, A; Zielkiewicz, J1
Hu, CY; Kokubo, H; Pettitt, BM1
Heisler, IA; Mazur, K; Meech, SR1
Graziano, G1
Nase, J; Paulus, M; Sahle, CJ; Schroer, MA; Tolan, M; Wieland, DC; Winter, R; Zhai, Y1
Jackson-Atogi, R; Rösgen, J1
Hatori, K; Kumemoto, R; Shibayama, T; Yusa, K1
Deniz, AA; Ferreon, AC; Gambin, Y; Moosa, MM1
Gai, F; Pazos, IM1
Canchi, DR; García, AE1
Minton, AP; Wu, D1
Erwin, N; Estel, K; Seeliger, J; Winter, R1
Paul, S; Sarma, R1
Berne, BJ; Mondal, J; Stirnemann, G1
Dong, Y; Tu, X; Yu, J; Zhang, X1
Myers, JK; Silvers, TR1
Gai, F; Ma, J; Pazos, IM1
Burke, T; Coumoundouros, C; Culham, DE; Deutch, CE; Ellinger, J; Kerr, CH; Murdock, L; Plater, SM; To, E; Wood, JM; Wright, G1
Bakker, HJ; Bonn, M; Hunger, J; Mazur, K; Ottosson, N1
Das Mahanta, D; Kumar Mitra, R; Samanta, N1
Rosin, C; Schummel, PH; Winter, R1
Rösgen, J1
Feinstein, SC; LaPointe, NE; Larini, L; Levine, ZA; Shea, JE1
Barnett, D; Currie, S; MacCormack, T; MacLellan, RJ; Tunnah, L; Wright, PA1
Berne, BJ; Halverson, D; Li, IT; Mondal, J; Stirnemann, G; Walker, GC1
Ganguly, P; Hajari, T; Shea, JE; van der Vegt, NF1
Luong, TQ; Winter, R1
DeOreo, P; Dobre, MA; Hai, X; Hostetter, TH; Landeras, V; Meyer, TW1
Coughlin, DJ; Gezzi, NL; Long, GM; Modi, PM; Woluko, KN1
Borgohain, G; Paul, S1
Garringer, M; Qasim, MA1
Li, W; Mu, Y; Yang, Y1
Haag, A; Kalbitzer, HR; Kremer, W; Schummel, PH; Winter, R1
Hong, J; Xiong, S1
Gao, M; Schummel, PH; Winter, R1
Guseman, AJ; Pielak, GJ1
Arns, L; Gao, M; Winter, R1
Anikeenko, AV; Geiger, A; Medvedev, NN; Smolin, N; Voloshin, VP; Winter, R1
Anders, C; Erwin, N; Patra, S; Winter, R1
Al-Ayoubi, SR; Golub, M; Peters, J; Schummel, PH; Winter, R1
Martínez, L; Shimizu, S1
Boserman, P; Ganguly, P; Shea, JE; van der Vegt, NFA1
Cho, M; Kundu, A; Verma, PK1
Anderson, WG; Brandt, C; Evans, AN; Lambert, FN; Treberg, JR1
Grover, A; Kumari, A; Rajput, R; Shrivastava, N; Somvanshi, P1
Canales, R; Held, C; Luong, TQ; Sadowski, G; Verevkin, SP; Wangler, A; Winter, R; Zaitsau, DH1
Jaworek, MW; Schuabb, V; Winter, R1
Gupta, A; Netz, RR; Pham, QD; Schlaich, A; Schneck, E; Sparr, E; Wolde-Kidan, A1
Bethea, J; Boland, C; Boutwell, L; Cauley, J; Hammer, NI; Magers, DH; Prather, JC; Smith, SA; Verville, GA; Warren, KE; Zetterholm, SG1
Högg, J; Jaworek, MW; Rosin, C; Schummel, PH; Winter, R1
Chi, MC; Lan, YG; Lin, LL; Lin, MG; Lo, HF; Wang, TF1
Kiesel, I; Knop, JM; Oliva, R; Patra, S; Schuabb, V; Winter, R1
Ichiye, T; Teng, X2
Anders, C; Arns, L; Knop, JM; Patra, S; Winter, R1
Geiger, A; Medvedev, NN; Smolin, N; Voloshin, V; Winter, R1
Anand, DV; Mu, Y; Shikhar, S; Xia, K1
Held, C; Knierbein, M; Luong, TQ; Sadowski, G; Wangler, A; Winter, R1
Bartoszewicz, M; Giebułtowicz, J; Kasprowicz, K; Korytowska, N; Ratkowski, W; Renke, M; Rita-Tkachenko, P; Wołyniec, W; Zorena, K1
Ganguly, P; Heyda, J; Polák, J; Shea, JE; van der Vegt, NFA1
Timson, DJ1
Anand, DV; Meng, Z; Mu, Y; Xia, K1
Folberth, A; Heyda, J; Polák, J; van der Vegt, NFA1
Herrmann, C; Schnatwinkel, J1
Oprzeska-Zingrebe, EA; Smiatek, J1
André, C; Bennis, Y; Bodeau, S; Choukroun, G; Kamel, S; Lemaire-Hurtel, AS; Liabeuf, S; Masmoudi, K1
Daschakraborty, S; Maiti, A2
Biernacki, KA; Bruździak, P; Demkowicz, S; Jacek, K; Kuffel, A; Panuszko, A; Pieloszczyk, M; Stangret, J1
Dixit, M; Hajari, T; Yadav, HOS1
Bhat, MY; Dar, TA; Mir, IA; Singh, LR; Ul Hussain, M1
Bakhshi, R; Kumari, K; Singh, K; Singh, KS; Singh, LR1
Hoang, HN; Housaindokht, MR; Matsuda, T; Monhemi, H; Standley, DM1
Baker, DL; Dougan, L; Laurent, H; Nasralla, M; Ries, ME1
Harries, D; Shakhman, Y; Shumilin, I1
Boob, MM; Gruebele, M; Pogorelov, TV; Sukenik, S1
Funabara, D; Ito, H; Kanoh, S; Noma, T; Tsureyama, M1
Arsiccio, A; Bowers, MT; Buratto, SK; Ganguly, P; Liu, X; Shea, JE1

Reviews

6 review(s) available for urea and trimethyloxamine

ArticleYear
The influence of feeding and fasting on plasma metabolites in the dogfish shark (Squalus acanthias).
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2010, Volume: 155, Issue:4

    Topics: 3-Hydroxybutyric Acid; Amino Acids; Ammonia; Animals; Blood Glucose; Dogfish; Eating; Energy Metabolism; Fasting; Fatty Acids, Nonesterified; Feeding Behavior; Methylamines; Osmolar Concentration; Postprandial Period; Predatory Behavior; Time Factors; Urea

2010
Cosolvent effects on protein stability.
    Annual review of physical chemistry, 2013, Volume: 64

    Topics: Animals; Excipients; Humans; Methylamines; Molecular Dynamics Simulation; Protein Denaturation; Protein Stability; Proteins; Solvents; Urea; Water

2013
Single-molecule insights into the temperature and pressure dependent conformational dynamics of nucleic acids in the presence of crowders and osmolytes.
    Biophysical chemistry, 2019, Volume: 251

    Topics: Chlorohydrins; DNA; Fluorescence Resonance Energy Transfer; Glycine; Humans; Methylamines; Nucleic Acid Conformation; Pressure; RNA; Sucrose; Temperature; Urea

2019
Protein Stability in TMAO and Mixed Urea-TMAO Solutions.
    The journal of physical chemistry. B, 2020, 07-23, Volume: 124, Issue:29

    Topics: Methylamines; Protein Stability; Solutions; Urea; Water

2020
The roles and applications of chaotropes and kosmotropes in industrial fermentation processes.
    World journal of microbiology & biotechnology, 2020, Jun-08, Volume: 36, Issue:6

    Topics: Alcohols; Amino Acids, Diamino; Bacillus subtilis; Biofuels; Bioreactors; Butanols; Ethanol; Fermentation; Genes, Bacterial; Genes, Fungal; Glycerol; Methylamines; Protein Structure, Secondary; Saccharomyces cerevisiae; Sulfides; Urea; Water; Yeasts; Zymomonas

2020
TMAO to the rescue of pathogenic protein variants.
    Biochimica et biophysica acta. General subjects, 2022, Volume: 1866, Issue:11

    Topics: Humans; Methylamines; Mutant Proteins; Proteins; Urea

2022

Other Studies

137 other study(ies) available for urea and trimethyloxamine

ArticleYear
Efflux and accumulation of amino nitrogen in relation to the volume of rat renal inner medullary cells exposed to media of variable osmolality.
    Biochimica et biophysica acta, 1992, Feb-03, Volume: 1133, Issue:3

    Topics: Amines; Aminoisobutyric Acids; Animals; Biological Transport; Egtazic Acid; Female; Humans; In Vitro Techniques; Kidney Medulla; Meglumine; Methylamines; Osmolar Concentration; Rats; Rats, Inbred Strains; Sodium Chloride; Trifluoperazine; Urea; Water

1992
Purification and properties of glutamine synthetase from liver of Squalus acanthias.
    Archives of biochemistry and biophysics, 1985, May-15, Volume: 239, Issue:1

    Topics: Animals; Chlorides; Chromatography, Gel; Dogfish; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutamate-Ammonia Ligase; Kinetics; Methylamines; Mitochondria, Liver; Molecular Weight; Sharks; Urea

1985
Effects of urea and trimethylamine-N-oxide on enzyme activity and stability.
    Archives of biochemistry and biophysics, 1987, Nov-01, Volume: 258, Issue:2

    Topics: Alcohol Dehydrogenase; Argininosuccinate Lyase; Catalase; Enzyme Inhibitors; Enzyme Stability; Hot Temperature; Kinetics; Lyases; Methylamines; Urea; Xanthine Oxidase

1987
Effects of urea, trimethylamine oxide, and osmolality on respiration and citrulline synthesis by isolated hepatic mitochondria from Squalus acanthias.
    Comparative biochemistry and physiology. B, Comparative biochemistry, 1986, Volume: 85, Issue:4

    Topics: Animals; Citrulline; Dogfish; Kinetics; Methylamines; Mitochondria, Liver; Osmolar Concentration; Oxygen Consumption; Sharks; Urea

1986
TMAO (trimethylamine oxide)-independence of oxygen affinity and its urea and ATP sensitivities in an elasmobranch hemoglobin.
    The Journal of experimental zoology, 1983, Volume: 228, Issue:3

    Topics: Adenosine Triphosphate; Animals; Dogfish; Hemoglobins; Methylamines; Oxygen; Oxyhemoglobins; Sharks; Urea

1983
Purification and properties of the glutamine- and N-acetyl-L-glutamate-dependent carbamoyl phosphate synthetase from liver of Squalus acanthias.
    The Journal of biological chemistry, 1981, Dec-10, Volume: 256, Issue:23

    Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Dogfish; Kinetics; Ligases; Liver; Methylamines; Nitrogen Oxides; Urea

1981
Why do some organisms use a urea-methylamine mixture as osmolyte? Thermodynamic compensation of urea and trimethylamine N-oxide interactions with protein.
    Biochemistry, 1994, Oct-25, Volume: 33, Issue:42

    Topics: Methylamines; Models, Chemical; Osmolar Concentration; Protein Denaturation; Ribonuclease T1; Solvents; Thermodynamics; Urea; Water; Water-Electrolyte Balance

1994
Interactions of the regulatory ligands Mg2+ and MgATP2- with the renal plasma membrane Ca(2+)-ATPase: effects of osmolytes that stabilize or destabilize protein structure.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1993, Volume: 26, Issue:4

    Topics: Adenosine Triphosphate; Animals; Binding Sites; Calcium-Transporting ATPases; Cell Membrane; Drug Interactions; Enzyme Activation; In Vitro Techniques; Kidney Tubules, Proximal; Ligands; Magnesium; Methylamines; Oxidants; Rabbits; Sucrose; Urea

1993
Do Australian desert frogs co-accumulate counteracting solutes with urea during aestivation?
    The Journal of experimental biology, 1996, Volume: 199, Issue:Pt 8

    Topics: Animals; Anura; Australia; Betaine; Body Fluids; Chromatography, High Pressure Liquid; Estivation; Glycerylphosphorylcholine; Inositol; Methylamines; Muscles; Osmolar Concentration; Polymers; Sarcosine; Urea

1996
A naturally occurring protective system in urea-rich cells: mechanism of osmolyte protection of proteins against urea denaturation.
    Biochemistry, 1997, Jul-29, Volume: 36, Issue:30

    Topics: Amino Acids; Animals; Diketopiperazines; Elasmobranchii; Methylamines; Oxidants; Piperazines; Protein Conformation; Protein Denaturation; Solubility; Temperature; Thermodynamics; Urea; Water-Electrolyte Balance

1997
Natural osmolyte trimethylamine N-oxide stimulates tubulin polymerization and reverses urea inhibition.
    The American journal of physiology, 1997, Volume: 273, Issue:2 Pt 2

    Topics: Animals; Cold Temperature; Methylamines; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Osmolar Concentration; Polymers; Rats; Tubulin; Urea

1997
Urea and methylamines have similar effects on aldose reductase activity.
    The American journal of physiology, 1997, Volume: 273, Issue:6

    Topics: Aldehyde Reductase; Animals; Betaine; Enzyme Inhibitors; Glycerylphosphorylcholine; Kidney Medulla; Kinetics; Lens, Crystalline; Methylamines; Rats; Recombinant Proteins; Urea

1997
Effects of glycine betaine and glycerophosphocholine on thermal stability of ribonuclease.
    The American journal of physiology, 1998, Volume: 274, Issue:4

    Topics: Animals; Betaine; Cattle; Drug Combinations; Drug Stability; Glycerylphosphorylcholine; Hot Temperature; Methylamines; Ribonuclease, Pancreatic; Urea

1998
Time-dependent effects of trimethylamine-N-oxide/urea on lactate dehydrogenase activity: an unexplored dimension of the adaptation paradigm.
    Biophysical journal, 1998, Volume: 74, Issue:5

    Topics: Animals; Kinetics; L-Lactate Dehydrogenase; Macromolecular Substances; Methylamines; Muscle, Skeletal; Oxidants; Rabbits; Time Factors; Urea

1998
Trimethylamine-N-oxide counteracts urea effects on rabbit muscle lactate dehydrogenase function: a test of the counteraction hypothesis.
    Biophysical journal, 1998, Volume: 74, Issue:5

    Topics: Animals; Kinetics; L-Lactate Dehydrogenase; Methylamines; Models, Chemical; Muscle, Skeletal; Oxidants; Rabbits; Urea

1998
Effects of urea and trimethylamine N-oxide on fluidity of liposomes and membranes of an elasmobranch.
    The American journal of physiology, 1999, Volume: 276, Issue:2

    Topics: Animals; Erythrocyte Membrane; Female; Fluorescence Polarization; Liposomes; Male; Membrane Fluidity; Methylamines; Skates, Fish; Temperature; Urea

1999
Novel cardiac protective effects of urea: from shark to rat.
    British journal of pharmacology, 1999, Volume: 128, Issue:7

    Topics: Animals; Dogfish; Electrolysis; Female; Heart; In Vitro Techniques; Male; Methylamines; Myocardial Reperfusion Injury; Myocardium; Oxidants; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Species Specificity; Urea; Ventricular Function, Left

1999
Microscopic stability of cold shock protein A examined by NMR native state hydrogen exchange as a function of urea and trimethylamine N-oxide.
    Protein science : a publication of the Protein Society, 2000, Volume: 9, Issue:2

    Topics: Bacterial Proteins; Circular Dichroism; Drug Stability; Hydrogen; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylamines; Models, Molecular; Protein Conformation; Protein Denaturation; Protein Structure, Secondary; Thermodynamics; Urea

2000
31P and 1H NMR studies of the effect of the counteracting osmolyte trimethylamine-N-oxide on interactions of urea with ribonuclease A.
    The Journal of biological chemistry, 2000, Sep-08, Volume: 275, Issue:36

    Topics: Animals; Cattle; Hydrogen; Methylamines; Nuclear Magnetic Resonance, Biomolecular; Oxidants; Phosphorus; Poly U; Protein Conformation; Ribonuclease, Pancreatic; Urea

2000
Functional protection of human haemoglobin against protein dissociation.
    IUBMB life, 2000, Volume: 50, Issue:2

    Topics: Adult; Erythrocytes; Hemoglobins; Humans; Methylamines; Models, Theoretical; Oxidants; Oxygen; Protein Binding; Protein Denaturation; Proteins; Urea

2000
Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism.
    Biochemistry, 2001, May-22, Volume: 40, Issue:20

    Topics: Anilino Naphthalenesulfonates; Animals; Anions; Benzothiazoles; Cattle; Chemistry, Physical; Excipients; Fluorescent Dyes; Hydrogen-Ion Concentration; Insulin; Kinetics; Methylamines; Models, Chemical; Osmolar Concentration; Protein Denaturation; Salts; Sonication; Sucrose; Surface Properties; Thiazoles; Urea

2001
Effect of salinity on flavin-containing monooxygenase expression and activity in rainbow trout (Oncorhynchus mykiss).
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2001, Volume: 171, Issue:5

    Topics: Adaptation, Physiological; Age Factors; Animals; Fresh Water; Gills; Intestines; Kidney; Liver; Methylamines; Myocardium; Oncorhynchus mykiss; Oxygenases; Seawater; Urea; Water-Electrolyte Balance

2001
Volume-activated trimethylamine oxide efflux in red blood cells of spiny dogfish (Squalus acanthias).
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:3

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Ammonium Chloride; Animals; Cell Size; Dogfish; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme Precursors; Erythrocytes; Ethylene Glycol; Hypotonic Solutions; Intracellular Signaling Peptides and Proteins; Ion Transport; Methylamines; Niflumic Acid; Osmolar Concentration; Protein-Tyrosine Kinases; Quinine; src-Family Kinases; Syk Kinase; Taurine; Urea

2001
Near infra-red spectra of urea with glycine betaine or trimethylamine N-oxide are additive.
    Biochimica et biophysica acta, 2001, Oct-03, Volume: 1528, Issue:2-3

    Topics: Betaine; Hydrogen Bonding; Methylamines; Solutions; Spectroscopy, Near-Infrared; Thermodynamics; Urea

2001
The molecular mechanism of stabilization of proteins by TMAO and its ability to counteract the effects of urea.
    Journal of the American Chemical Society, 2002, Feb-20, Volume: 124, Issue:7

    Topics: Calorimetry; Hydrogen Bonding; Methylamines; Proteins; Solutions; Thermodynamics; Urea; Water

2002
The freeze-avoidance response of smelt Osmerus mordax: initiation and subsequent suppression of glycerol, trimethylamine oxide and urea accumulation.
    The Journal of experimental biology, 2002, Volume: 205, Issue:Pt 10

    Topics: Acclimatization; Animals; Body Temperature; Freezing; Glycerol; Liver; Methylamines; Osmolar Concentration; Salmoniformes; Seasons; Temperature; Urea

2002
Osmolyte effects on helix formation in peptides and the stability of coiled-coils.
    Protein science : a publication of the Protein Society, 2002, Volume: 11, Issue:8

    Topics: Alanine; Amino Acid Sequence; Circular Dichroism; Dimerization; DNA-Binding Proteins; Leucine Zippers; Methylamines; Molecular Sequence Data; Osmolar Concentration; Protein Denaturation; Protein Folding; Protein Kinases; Protein Structure, Secondary; Saccharomyces cerevisiae Proteins; Trifluoroethanol; Urea

2002
Counteracting effects of urea and methylamines in function and structure of skeletal muscle myosin.
    Archives of biochemistry and biophysics, 2002, Dec-15, Volume: 408, Issue:2

    Topics: Adenosine Triphosphatases; Animals; Betaine; Fluorescence; Methylamines; Protein Conformation; Protein Structure, Tertiary; Skeletal Muscle Myosins; Urea

2002
Trimethylamine N-oxide stabilizes RNA tertiary structure and attenuates the denaturating effects of urea.
    Journal of the American Chemical Society, 2003, Apr-16, Volume: 125, Issue:15

    Topics: Escherichia coli; Methylamines; Nucleic Acid Conformation; RNA, Bacterial; RNA, Transfer, Met; Thermodynamics; Urea

2003
Hydrogen exchange kinetics of RNase A and the urea:TMAO paradigm.
    Biochemistry, 2003, May-20, Volume: 42, Issue:19

    Topics: Adaptation, Physiological; Binding Sites; Deuterium; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Methylamines; Protein Denaturation; Ribonuclease, Pancreatic; Thermodynamics; Urea

2003
Measuring the stability of partly folded proteins using TMAO.
    Protein science : a publication of the Protein Society, 2003, Volume: 12, Issue:7

    Topics: Methylamines; Osmolar Concentration; Oxidants; Protein Denaturation; Protein Folding; Proteins; Solvents; Thermodynamics; Urea

2003
Protein stability in mixed solvents: a balance of contact interaction and excluded volume.
    Biophysical journal, 2003, Volume: 85, Issue:1

    Topics: Algorithms; Binding Sites; Complex Mixtures; Computer Simulation; Databases, Protein; Guanidine; Methylamines; Models, Chemical; Models, Molecular; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Proteins; Solvents; Sucrose; Surface Properties; Urea; Water

2003
Glutamate counteracts the denaturing effect of urea through its effect on the denatured state.
    The Journal of biological chemistry, 2003, Sep-19, Volume: 278, Issue:38

    Topics: Amino Acyl-tRNA Synthetases; Animals; Betaine; Carbonic Anhydrases; Cattle; Dose-Response Relationship, Drug; Escherichia coli; Glutamates; Glutamic Acid; Inositol; Kinetics; Methylamines; Oxidants; Potassium Chloride; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Sorbitol; Spectrophotometry; Temperature; Thermodynamics; Time Factors; Trypsin; Tubulin; Urea

2003
Osmolyte effects on kinetics of FKBP12 C22A folding coupled with prolyl isomerization.
    Journal of molecular biology, 2003, Jul-18, Volume: 330, Issue:4

    Topics: Dose-Response Relationship, Drug; Escherichia coli; Humans; Kinetics; Methylamines; Models, Molecular; Oxidants; Peptidylprolyl Isomerase; Protein Denaturation; Protein Folding; Recombinant Proteins; Tacrolimus Binding Protein 1A; Thermodynamics; Time Factors; Urea

2003
Regulation of a renal urea transporter with reduced salinity in a marine elasmobranch, Raja erinacea.
    The Journal of experimental biology, 2003, Volume: 206, Issue:Pt 18

    Topics: Amino Acid Sequence; Analysis of Variance; Animals; Blotting, Northern; DNA Primers; DNA, Complementary; Down-Regulation; Membrane Transport Proteins; Methylamines; Molecular Sequence Data; New Brunswick; Osmolar Concentration; Reverse Transcriptase Polymerase Chain Reaction; Seawater; Sequence Alignment; Sequence Analysis, DNA; Skates, Fish; Urea; Urea Transporters

2003
Activation of halophilic nucleoside diphosphate kinase by a non-ionic osmolyte, trimethylamine N-oxide.
    Journal of protein chemistry, 2003, Volume: 22, Issue:4

    Topics: Circular Dichroism; Enzyme Activation; Halobacterium salinarum; Hot Temperature; Hydrogen-Ion Concentration; Methylamines; Nucleoside-Diphosphate Kinase; Potassium Chloride; Protein Conformation; Protein Denaturation; Protein Folding; Sodium Chloride; Time Factors; Urea

2003
Haemoglobin function and respiratory status of the Port Jackson shark, Heterodontus portusjacksoni, in response to lowered salinity.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2004, Volume: 174, Issue:3

    Topics: Acclimatization; Animals; Body Weight; Carbon Dioxide; Cardiac Output; Erythrocytes; Hematocrit; Hemoglobins; Hydrogen-Ion Concentration; Lactic Acid; Methylamines; Oxygen; Oxygen Consumption; Partial Pressure; Pulmonary Ventilation; Respiratory Mechanics; Respiratory Physiological Phenomena; Seawater; Sharks; Sodium Chloride; Urea

2004
Counteraction of urea-induced protein denaturation by trimethylamine N-oxide: a chemical chaperone at atomic resolution.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Apr-27, Volume: 101, Issue:17

    Topics: Methylamines; Models, Molecular; Protein Denaturation; Solvents; Urea

2004
Dogmas and controversies in the handling of nitrogenous wastes: osmoregulation during early embryonic development in the marine little skate Raja erinacea; response to changes in external salinity.
    The Journal of experimental biology, 2004, Volume: 207, Issue:Pt 12

    Topics: Analysis of Variance; Animals; Arginase; Carbon-Nitrogen Ligases; Colorimetry; Embryo, Nonmammalian; Glutamate-Ammonia Ligase; Methylamines; Ornithine Carbamoyltransferase; Seawater; Skates, Fish; Spectrophotometry; Time Factors; Urea; Water-Electrolyte Balance

2004
Osmolytes induce structure in an early intermediate on the folding pathway of barstar.
    The Journal of biological chemistry, 2004, Sep-24, Volume: 279, Issue:39

    Topics: Bacterial Proteins; Circular Dichroism; Dose-Response Relationship, Drug; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methylamines; Models, Chemical; Plasmids; Protein Conformation; Protein Denaturation; Protein Folding; Sarcosine; Spectrophotometry; Temperature; Thermodynamics; Time Factors; Ultraviolet Rays; Urea

2004
A comparison of the counteracting effects of glycine betaine and TMAO on the activity of RNase A in aqueous urea solution.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2005, Volume: 141, Issue:1

    Topics: Animals; Betaine; Catalysis; Cattle; Magnetic Resonance Spectroscopy; Methylamines; Molecular Structure; Ribonuclease, Pancreatic; RNA; Solutions; Urea

2005
A natural osmolyte trimethylamine N-oxide promotes assembly and bundling of the bacterial cell division protein, FtsZ and counteracts the denaturing effects of urea.
    The FEBS journal, 2005, Volume: 272, Issue:11

    Topics: Anilino Naphthalenesulfonates; Bacterial Proteins; Cell Division; Cytoskeletal Proteins; Fluorescent Dyes; Glutamic Acid; GTP Phosphohydrolases; Guanidine; Methylamines; Parasympathomimetics; Protein Conformation; Protein Denaturation; Protein Folding; Urea

2005
Effects of urea and trimethylamine-N-oxide (TMAO) on the interactions of lysozyme in solution.
    Biophysical journal, 2005, Volume: 89, Issue:3

    Topics: Animals; Biophysics; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Methylamines; Models, Statistical; Multiprotein Complexes; Muramidase; Potassium Chloride; Protein Denaturation; Scattering, Radiation; Solutions; Synchrotrons; Temperature; Thermodynamics; Time Factors; Urea; Water; X-Rays

2005
Alkaline tide and nitrogen conservation after feeding in an elasmobranch (Squalus acanthias).
    The Journal of experimental biology, 2005, Volume: 208, Issue:Pt 14

    Topics: Acid-Base Equilibrium; Ammonia; Analysis of Variance; Animals; Bicarbonates; Blood Glucose; British Columbia; Carbon Dioxide; Hydrogen-Ion Concentration; Methylamines; Nitrogen; Oxygen; Postprandial Period; Squalus acanthias; Time Factors; Urea; Water-Electrolyte Balance

2005
Lactate dehydrogenase undergoes a substantial structural change to bind its substrate.
    Biophysical journal, 2007, Sep-01, Volume: 93, Issue:5

    Topics: Animals; Binding Sites; Kinetics; L-Lactate Dehydrogenase; Methylamines; Models, Molecular; Myocardium; NAD; Protein Binding; Protein Conformation; Solvents; Substrate Specificity; Swine; Temperature; Urea

2007
Effects of osmolytes on RNA secondary and tertiary structure stabilities and RNA-Mg2+ interactions.
    Journal of molecular biology, 2007, Jul-27, Volume: 370, Issue:5

    Topics: Base Sequence; Betaine; Cations, Divalent; Ethylene Glycol; Magnesium; Methanol; Methylamines; Molecular Sequence Data; Nucleic Acid Conformation; Osmotic Pressure; Proline; RNA; RNA Stability; Sucrose; Sugar Alcohols; Thermodynamics; Urea

2007
The influence of urea and trimethylamine-N-oxide on hydrophobic interactions.
    The journal of physical chemistry. B, 2007, Jul-19, Volume: 111, Issue:28

    Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Models, Chemical; Pentanes; Protein Denaturation; Protein Folding; Solutions; Urea

2007
Effects of osmolytes on hexokinase kinetics combined with macromolecular crowding: test of the osmolyte compatibility hypothesis towards crowded systems.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2007, Volume: 148, Issue:2

    Topics: Betaine; Buffers; Catalysis; Fungal Proteins; Glycerol; Hexokinase; Kinetics; Methylamines; Models, Chemical; Osmotic Pressure; Protein Binding; Serum Albumin, Bovine; Sodium Chloride; Urea; Water

2007
Effects of cell volume regulating osmolytes on glycerol 3-phosphate binding to triosephosphate isomerase.
    Biochemistry, 2007, Sep-04, Volume: 46, Issue:35

    Topics: Algorithms; Cell Size; Dose-Response Relationship, Drug; Enzyme Activation; Glycerophosphates; Kinetics; Methylamines; Models, Chemical; Models, Molecular; Osmosis; Protein Binding; Protein Denaturation; Protein Folding; Sodium Chloride; Substrate Specificity; Thermodynamics; Triose-Phosphate Isomerase; Urea

2007
Trimethylamine N-oxide counteracts the denaturing effects of urea or GdnHCl on protein denatured state.
    Archives of biochemistry and biophysics, 2007, Oct-01, Volume: 466, Issue:1

    Topics: Dipeptides; Guanidine; Methylamines; Protein Conformation; Protein Denaturation; Protein Folding; Urea

2007
Simulations of macromolecules in protective and denaturing osmolytes: properties of mixed solvent systems and their effects on water and protein structure and dynamics.
    Methods in enzymology, 2007, Volume: 428

    Topics: Computer Simulation; Hydrogen Bonding; Methylamines; Models, Molecular; Osmotic Pressure; Peptides; Plant Proteins; Protein Denaturation; Proteins; Solvents; Urea; Water

2007
Measuring the interaction of urea and protein-stabilizing osmolytes with the nonpolar surface of hydroxypropylcellulose.
    Biochemistry, 2008, Jun-24, Volume: 47, Issue:25

    Topics: Algorithms; Betaine; Cellulose; Glycerol; Hydrophobic and Hydrophilic Interactions; Methylamines; Models, Chemical; Organic Chemicals; Osmotic Pressure; Proteins; Scattering, Radiation; Sorbitol; Temperature; Thermodynamics; Urea; X-Rays

2008
Hydrophobic interactions in urea-trimethylamine-N-oxide solutions.
    The journal of physical chemistry. B, 2008, Sep-04, Volume: 112, Issue:35

    Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Pentanes; Solutions; Surface-Active Agents; Temperature; Urea

2008
Effect of osmolytes on pressure-induced unfolding of proteins: a high-pressure SAXS study.
    Chemphyschem : a European journal of chemical physics and physical chemistry, 2008, Dec-22, Volume: 9, Issue:18

    Topics: Glycerol; Methylamines; Micrococcal Nuclease; Pressure; Protein Conformation; Protein Denaturation; Protein Stability; Scattering, Small Angle; Solutions; Temperature; Urea; X-Ray Diffraction

2008
Rescue of the neuroblastoma mutant of the human nucleoside diphosphate kinase A/nm23-H1 by the natural osmolyte trimethylamine-N-oxide.
    FEBS letters, 2009, Feb-18, Volume: 583, Issue:4

    Topics: Dose-Response Relationship, Drug; Humans; Kinetics; Methylamines; Neoplasm Proteins; Neuroblastoma; NM23 Nucleoside Diphosphate Kinases; Point Mutation; Protein Folding; Urea

2009
Influence of surface groups of proteins on water studied by freezing/thawing hysteresis and infrared spectroscopy.
    Biophysical chemistry, 2009, Volume: 141, Issue:2-3

    Topics: Ammonium Chloride; Animals; Antifreeze Proteins; Cattle; Cytochromes c; Flounder; Freezing; Glutamic Acid; Guanidine; Methanol; Methylamines; Peptides; Polylysine; Proteins; Serum Albumin, Bovine; Sodium Acetate; Spectrophotometry, Infrared; Temperature; Transition Temperature; Urea; Water

2009
Effects of urea and trimethylamine-N-oxide on the properties of water and the secondary structure of hen egg white lysozyme.
    The journal of physical chemistry. B, 2009, Nov-05, Volume: 113, Issue:44

    Topics: Animals; Calorimetry; Chickens; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Muramidase; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Urea; Water

2009
Counteraction of urea by trimethylamine N-oxide is due to direct interaction.
    Biophysical journal, 2009, Nov-04, Volume: 97, Issue:9

    Topics: Biophysics; Computer Simulation; Hydrogen; Hydrogen Bonding; Hydrogen-Ion Concentration; Methylamines; Models, Chemical; Neutrons; Oxygen; Peptides; Scattering, Radiation; Solutions; Solvents; Urea; Water

2009
Osmolyte-induced conformational changes in the Hsp90 molecular chaperone.
    Protein science : a publication of the Protein Society, 2010, Volume: 19, Issue:1

    Topics: Adenylyl Imidodiphosphate; Betaine; Escherichia coli Proteins; Glycerol; HSP90 Heat-Shock Proteins; Methylamines; Models, Molecular; Osmosis; Protein Conformation; Sarcosine; Scattering, Small Angle; Urea; X-Ray Diffraction

2010
Effects of urea, tetramethyl urea, and trimethylamine N-oxide on aqueous solution structure and solvation of protein backbones: a molecular dynamics simulation study.
    The journal of physical chemistry. B, 2010, Jan-14, Volume: 114, Issue:1

    Topics: Hydrogen Bonding; Methylamines; Methylurea Compounds; Molecular Dynamics Simulation; Peptides; Protein Denaturation; Urea; Water

2010
Effects of cosolvents on the hydration of carbon nanotubes.
    Journal of the American Chemical Society, 2010, Jan-20, Volume: 132, Issue:2

    Topics: Hydrogen Bonding; Methanol; Methylamines; Molecular Dynamics Simulation; Nanotubes, Carbon; Particle Size; Solvents; Static Electricity; Surface Properties; Urea; Water

2010
Hydrogen bonding progressively strengthens upon transfer of the protein urea-denatured state to water and protecting osmolytes.
    Biochemistry, 2010, Feb-16, Volume: 49, Issue:6

    Topics: Animals; Ankyrin Repeat; Drosophila Proteins; Gene Deletion; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Methylamines; Osmosis; Peptide Fragments; Protein Denaturation; Protein Stability; Protein Structure, Tertiary; Protein Transport; Receptors, Notch; Sarcosine; Thermodynamics; Urea; Water

2010
Backbone additivity in the transfer model of protein solvation.
    Protein science : a publication of the Protein Society, 2010, Volume: 19, Issue:5

    Topics: Glycine; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Oligopeptides; Osmolar Concentration; Protein Conformation; Protein Folding; Proteins; Solvents; Static Electricity; Thermodynamics; Urea; Water

2010
The hydrogen bond network structure within the hydration shell around simple osmolytes: urea, tetramethylurea, and trimethylamine-N-oxide, investigated using both a fixed charge and a polarizable water model.
    The Journal of chemical physics, 2010, Jul-21, Volume: 133, Issue:3

    Topics: Hydrogen Bonding; Methylamines; Methylurea Compounds; Molecular Dynamics Simulation; Osmosis; Probability; Solvents; Urea; Water

2010
Peptide conformational preferences in osmolyte solutions: transfer free energies of decaalanine.
    Journal of the American Chemical Society, 2011, Feb-16, Volume: 133, Issue:6

    Topics: Alanine; Methylamines; Molecular Dynamics Simulation; Oligopeptides; Osmosis; Protein Denaturation; Protein Structure, Secondary; Solutions; Thermodynamics; Urea; Water

2011
THz spectra and dynamics of aqueous solutions studied by the ultrafast optical Kerr effect.
    The journal of physical chemistry. B, 2011, Mar-24, Volume: 115, Issue:11

    Topics: Formamides; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Methylamines; Methylurea Compounds; Models, Molecular; Quantum Theory; Solutions; Terahertz Spectroscopy; Urea; Water

2011
An X-ray and neutron scattering study of the equilibrium between trimethylamine N-oxide and urea in aqueous solution.
    Physical chemistry chemical physics : PCCP, 2011, Aug-14, Volume: 13, Issue:30

    Topics: Methylamines; Neutron Diffraction; Oxides; Protein Binding; Proteins; Scattering, Radiation; Scattering, Small Angle; Urea; Water; X-Ray Diffraction

2011
How does trimethylamine N-oxide counteract the denaturing activity of urea?
    Physical chemistry chemical physics : PCCP, 2011, Oct-21, Volume: 13, Issue:39

    Topics: Methylamines; Protein Conformation; Protein Denaturation; Proteins; Surface Properties; Thermodynamics; Urea

2011
Exploring the piezophilic behavior of natural cosolvent mixtures.
    Angewandte Chemie (International ed. in English), 2011, Nov-25, Volume: 50, Issue:48

    Topics: Animals; Hydrostatic Pressure; Methylamines; Models, Molecular; Osmolar Concentration; Proteins; Scattering, Small Angle; Solvents; Urea; X-Ray Diffraction

2011
Volume exclusion and H-bonding dominate the thermodynamics and solvation of trimethylamine-N-oxide in aqueous urea.
    Journal of the American Chemical Society, 2012, Feb-22, Volume: 134, Issue:7

    Topics: Hydrogen Bonding; Methylamines; Solubility; Thermodynamics; Urea; Water

2012
Trimethylamine N-oxide suppresses the activity of the actomyosin motor.
    Biochimica et biophysica acta, 2012, Volume: 1820, Issue:10

    Topics: Actin Cytoskeleton; Actomyosin; Adenosine Triphosphatases; Animals; Dose-Response Relationship, Drug; Down-Regulation; In Vitro Techniques; Methylamines; Movement; Multiprotein Complexes; Myosin Subfragments; Osmolar Concentration; Protein Stability; Rabbits; Urea

2012
Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Oct-30, Volume: 109, Issue:44

    Topics: alpha-Synuclein; Fluorescence Resonance Energy Transfer; Methylamines; Molecular Chaperones; Protein Conformation; Urea

2012
Solute's perspective on how trimethylamine oxide, urea, and guanidine hydrochloride affect water's hydrogen bonding ability.
    The journal of physical chemistry. B, 2012, Oct-18, Volume: 116, Issue:41

    Topics: Guanidine; Hydrogen Bonding; Methylamines; Thermodynamics; Urea; Water

2012
Compensating effects of urea and trimethylamine-N-oxide on the heteroassociation of α-chymotrypsin and soybean trypsin inhibitor.
    The journal of physical chemistry. B, 2013, Apr-04, Volume: 117, Issue:13

    Topics: Chymotrypsin; Fluorescence; Glycine max; Hydrogen-Ion Concentration; Methylamines; Thermodynamics; Trypsin Inhibitor, Kunitz Soybean; Urea

2013
Cosolvent effects on the fibrillation reaction of human IAPP.
    Physical chemistry chemical physics : PCCP, 2013, Jun-21, Volume: 15, Issue:23

    Topics: Amyloid; Betaine; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Methylamines; Protein Stability; Protein Structure, Secondary; Urea

2013
Exploring the molecular mechanism of trimethylamine-N-oxide's ability to counteract the protein denaturing effects of urea.
    The journal of physical chemistry. B, 2013, May-09, Volume: 117, Issue:18

    Topics: Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Protein Denaturation; Proteins; Urea; Water

2013
When does trimethylamine N-oxide fold a polymer chain and urea unfold it?
    The journal of physical chemistry. B, 2013, Jul-25, Volume: 117, Issue:29

    Topics: Methylamines; Molecular Dynamics Simulation; Polymers; Protein Denaturation; Protein Folding; Urea

2013
Effects of environmental factors on MSP21-25 aggregation indicate the roles of hydrophobic and electrostatic interactions in the aggregation process.
    European biophysics journal : EBJ, 2014, Volume: 43, Issue:1

    Topics: Anilino Naphthalenesulfonates; Antigens, Protozoan; Benzothiazoles; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Methylamines; Peptide Fragments; Protein Multimerization; Protozoan Proteins; Sodium Dodecyl Sulfate; Static Electricity; Thiazoles; Urea

2014
Osmolyte effects on the self-association of concanavalin A: testing theoretical models.
    Biochemistry, 2013, Dec-23, Volume: 52, Issue:51

    Topics: Betaine; Circular Dichroism; Concanavalin A; Dimerization; Hydrogen-Ion Concentration; Indicators and Reagents; Methylamines; Models, Molecular; Osmolar Concentration; Proline; Protein Interaction Domains and Motifs; Protein Stability; Sarcosine; Secondary Metabolism; Sorbitol; Sucrose; Thermodynamics; Titrimetry; Trehalose; Urea

2013
Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO).
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Jun-10, Volume: 111, Issue:23

    Topics: Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylamines; Microfilament Proteins; Mutation; Peptides; Protein Conformation; Protein Folding; Protein Stability; Protein Unfolding; Proteins; Spectroscopy, Fourier Transform Infrared; Urea; Water

2014
Analysis of strains lacking known osmolyte accumulation mechanisms reveals contributions of osmolytes and transporters to protection against abiotic stress.
    Applied and environmental microbiology, 2014, Volume: 80, Issue:17

    Topics: Betaine; Culture Media; Escherichia coli; Methylamines; Osmotic Pressure; Proline; Sodium Chloride; Stress, Physiological; Sulfonium Compounds; Temperature; Urea

2014
Water-mediated interactions between trimethylamine-N-oxide and urea.
    Physical chemistry chemical physics : PCCP, 2015, Jan-07, Volume: 17, Issue:1

    Topics: Dielectric Spectroscopy; Hydrogen Bonding; Methylamines; Models, Molecular; Urea; Water

2015
Does urea alter the collective hydrogen-bond dynamics in water? A dielectric relaxation study in the terahertz-frequency region.
    Chemistry, an Asian journal, 2014, Volume: 9, Issue:12

    Topics: Electric Impedance; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Terahertz Spectroscopy; Urea; Water

2014
Cosolvent and crowding effects on the polymerization kinetics of actin.
    Physical chemistry chemical physics : PCCP, 2015, Apr-07, Volume: 17, Issue:13

    Topics: Actins; Dextrans; Kinetics; Methylamines; Polymerization; Protein Interaction Domains and Motifs; Proteins; Solvents; Time-Lapse Imaging; Urea

2015
Synergy in protein-osmolyte mixtures.
    The journal of physical chemistry. B, 2015, Jan-08, Volume: 119, Issue:1

    Topics: Methylamines; Models, Statistical; Osmolar Concentration; Proteins; Surface Properties; Thermodynamics; Urea

2015
Regulation and aggregation of intrinsically disordered peptides.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Mar-03, Volume: 112, Issue:9

    Topics: Humans; Methylamines; Molecular Dynamics Simulation; Peptides; Protein Aggregation, Pathological; Protein Structure, Secondary; tau Proteins; Urea

2015
Chaperone roles for TMAO and HSP70 during hyposmotic stress in the spiny dogfish shark (Squalus acanthias).
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2015, Volume: 185, Issue:7

    Topics: Adaptation, Physiological; Animals; Fish Proteins; Gills; HSP70 Heat-Shock Proteins; Male; Methylamines; Muscles; Osmotic Pressure; Salinity; Seawater; Sodium-Potassium-Exchanging ATPase; Squalus acanthias; Time Factors; Urea

2015
How osmolytes influence hydrophobic polymer conformations: A unified view from experiment and theory.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Jul-28, Volume: 112, Issue:30

    Topics: Computer Simulation; Hydrophobic and Hydrophilic Interactions; Methylamines; Microscopy, Atomic Force; Molecular Dynamics Simulation; Normal Distribution; Polymers; Polystyrenes; Protein Binding; Protein Conformation; Protein Folding; Proteins; Software; Solvents; Stress, Mechanical; Thermodynamics; Urea; Water

2015
Mutual Exclusion of Urea and Trimethylamine N-Oxide from Amino Acids in Mixed Solvent Environment.
    The journal of physical chemistry letters, 2015, Feb-19, Volume: 6, Issue:4

    Topics: Amino Acids; Methylamines; Molecular Dynamics Simulation; Solvents; Urea

2015
Combined pressure and cosolvent effects on enzyme activity - a high-pressure stopped-flow kinetic study on α-chymotrypsin.
    Physical chemistry chemical physics : PCCP, 2015, Sep-21, Volume: 17, Issue:35

    Topics: Biocatalysis; Chymotrypsin; Enzyme Activation; Hydrolysis; Kinetics; Methylamines; Peptides; Pressure; Solvents; Urea

2015
Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Adult; Biomarkers; Case-Control Studies; Creatinine; Female; Humans; Kidney Failure, Chronic; Male; Methylamines; Renal Dialysis; Urea

2015
Elevated osmolytes in rainbow smelt: the effects of urea, glycerol and trimethylamine oxide on muscle contractile properties.
    The Journal of experimental biology, 2016, Volume: 219, Issue:Pt 7

    Topics: Animals; Cold Temperature; Cryoprotective Agents; Glycerol; Methylamines; Muscle Contraction; Muscle Fibers, Fast-Twitch; Osmeriformes; Urea

2016
Model Dependency of TMAO's Counteracting Effect Against Action of Urea: Kast Model versus Osmotic Model of TMAO.
    The journal of physical chemistry. B, 2016, Mar-10, Volume: 120, Issue:9

    Topics: Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Osmosis; Static Electricity; Urea

2016
Effect of Osmolytes and Guanidinium Chloride on the Enzymatic Properties of Bovine α-Chymotrypsin.
    Protein and peptide letters, 2016, Volume: 23, Issue:6

    Topics: Animals; Betaine; Biocatalysis; Catalytic Domain; Cattle; Chymotrypsin; Guanidine; Kinetics; Methylamines; Peptides; Urea

2016
Microscopic significance of hydrophobic residues in the protein-stabilizing effect of trimethylamine N-oxide (TMAO).
    Physical chemistry chemical physics : PCCP, 2016, Aug-10, Volume: 18, Issue:32

    Topics: Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Methylamines; Molecular Conformation; Molecular Dynamics Simulation; Proteins; Urea

2016
Cosolvent and Crowding Effects on the Temperature and Pressure Dependent Conformational Dynamics and Stability of Globular Actin.
    The journal of physical chemistry. B, 2016, 07-14, Volume: 120, Issue:27

    Topics: Actins; Methylamines; Nuclear Magnetic Resonance, Biomolecular; Pressure; Protein Stability; Solvents; Spectrometry, Fluorescence; Temperature; Thermodynamics; Urea

2016
TMAO-Protein Preferential Interaction Profile Determines TMAO's Conditional In Vivo Compatibility.
    Biophysical journal, 2016, Nov-01, Volume: 111, Issue:9

    Topics: Amyloid beta-Peptides; Dose-Response Relationship, Drug; Drug Interactions; Hydrophobic and Hydrophilic Interactions; Methylamines; Osmosis; Peptide Fragments; Protein Binding; Protein Multimerization; Protein Stability; Protein Structure, Quaternary; Proteins; Substrate Specificity; Thermodynamics; Urea

2016
Modulation of the Polymerization Kinetics of α/β-Tubulin by Osmolytes and Macromolecular Crowding.
    Chemphyschem : a European journal of chemical physics and physical chemistry, 2017, Jan-18, Volume: 18, Issue:2

    Topics: Ficoll; Kinetics; Macromolecular Substances; Methylamines; Osmosis; Polymerization; Solvents; Sucrose; Tubulin; Urea

2017
Cosolute and Crowding Effects on a Side-By-Side Protein Dimer.
    Biochemistry, 2017, 02-21, Volume: 56, Issue:7

    Topics: Cytosol; Escherichia coli; Ficoll; Fluorine; Methylamines; Models, Molecular; Muramidase; Nuclear Magnetic Resonance, Biomolecular; Protein Multimerization; Protein Stability; Receptors, GABA-B; Serum Albumin, Bovine; Urea

2017
Modulation of the Thermodynamic Signatures of an RNA Thermometer by Osmolytes and Salts.
    Angewandte Chemie (International ed. in English), 2017, 02-20, Volume: 56, Issue:9

    Topics: Entropy; Methylamines; Nucleic Acid Conformation; Osmolar Concentration; RNA; RNA Folding; RNA Stability; Salts; Static Electricity; Temperature; Thermodynamics; Urea; Water

2017
TMAO and urea in the hydration shell of the protein SNase.
    Physical chemistry chemical physics : PCCP, 2017, Mar-01, Volume: 19, Issue:9

    Topics: Methylamines; Micrococcal Nuclease; Molecular Dynamics Simulation; Solvents; Temperature; Urea; Water

2017
Osmolyte Effects on the Conformational Dynamics of a DNA Hairpin at Ambient and Extreme Environmental Conditions.
    Angewandte Chemie (International ed. in English), 2017, 04-24, Volume: 56, Issue:18

    Topics: DNA; Fluorescence Resonance Energy Transfer; Hot Temperature; Methylamines; Nucleic Acid Conformation; Osmolar Concentration; Pressure; Thermodynamics; Urea

2017
Influence of cosolvents, self-crowding, temperature and pressure on the sub-nanosecond dynamics and folding stability of lysozyme.
    Physical chemistry chemical physics : PCCP, 2017, Jun-07, Volume: 19, Issue:22

    Topics: Hydrogen; Methylamines; Muramidase; Neutron Diffraction; Protein Folding; Temperature; Urea; Water

2017
Molecular Interpretation of Preferential Interactions in Protein Solvation: A Solvent-Shell Perspective by Means of Minimum-Distance Distribution Functions.
    Journal of chemical theory and computation, 2017, Dec-12, Volume: 13, Issue:12

    Topics: Methylamines; Molecular Dynamics Simulation; Ribonuclease T1; Solvents; Thermodynamics; Urea

2017
Trimethylamine N-oxide Counteracts Urea Denaturation by Inhibiting Protein-Urea Preferential Interaction.
    Journal of the American Chemical Society, 2018, 01-10, Volume: 140, Issue:1

    Topics: Methylamines; Molecular Dynamics Simulation; Osmotic Pressure; Peptides; Protein Binding; Protein Denaturation; tau Proteins; Urea; Water

2018
Effect of Osmolytes on the Conformational Behavior of a Macromolecule in a Cytoplasm-like Crowded Environment: A Femtosecond Mid-IR Pump-Probe Spectroscopy Study.
    The journal of physical chemistry letters, 2018, Feb-15, Volume: 9, Issue:4

    Topics: Ethers; Excipients; Glycine; Hydrogen Bonding; Methylamines; Molecular Conformation; Osmolar Concentration; Polyethylene Glycols; Protein Denaturation; Protein Stability; Sorbitol; Spectroscopy, Fourier Transform Infrared; Urea; Water

2018
The physiological stress response of the Atlantic stingray (Hypanus sabinus) to aerial exposure.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2018, Volume: 219-220

    Topics: 3-Hydroxybutyric Acid; Acidosis; Air; Animals; Blood Glucose; Homeostasis; Ketone Bodies; Lactic Acid; Male; Methylamines; Osmolar Concentration; Skates, Fish; Stress, Physiological; Urea

2018
Synergistic approaches unraveling regulation and aggregation of intrinsically disordered β-amyloids implicated in Alzheimer's disease.
    The international journal of biochemistry & cell biology, 2018, Volume: 99

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Intrinsically Disordered Proteins; Methylamines; Peptide Fragments; Protein Aggregation, Pathological; Urea

2018
Co-solvent effects on reaction rate and reaction equilibrium of an enzymatic peptide hydrolysis.
    Physical chemistry chemical physics : PCCP, 2018, Apr-25, Volume: 20, Issue:16

    Topics: Animals; Calcium Chloride; Cattle; Chymotrypsin; Dimethyl Sulfoxide; Hydrolysis; Kinetics; Methylamines; Phenylalanine; Sodium Chloride; Solvents; Thermodynamics; Urea; Water

2018
Pressure and cosolvent modulation of the catalytic activity of amyloid fibrils.
    Chemical communications (Cambridge, England), 2018, May-31, Volume: 54, Issue:45

    Topics: Amino Acid Sequence; Amyloid; Amyloidogenic Proteins; Catalysis; Ficoll; Kinetics; Methylamines; Molecular Dynamics Simulation; Pressure; Solvents; Spectroscopy, Fourier Transform Infrared; Temperature; Urea

2018
Effects of Urea and TMAO on Lipid Self-Assembly under Osmotic Stress Conditions.
    The journal of physical chemistry. B, 2018, 06-28, Volume: 122, Issue:25

    Topics: Calorimetry; Dimyristoylphosphatidylcholine; Magnetic Resonance Spectroscopy; Methylamines; Molecular Dynamics Simulation; Osmotic Pressure; Phosphatidylcholines; Urea; Water

2018
Noncovalent Interactions between Trimethylamine N-Oxide (TMAO), Urea, and Water.
    The journal of physical chemistry. B, 2018, 09-27, Volume: 122, Issue:38

    Topics: Hydrogen Bonding; Methylamines; Models, Chemical; Spectrum Analysis, Raman; Thermodynamics; Urea; Water

2018
Exploring the influence of natural cosolvents on the free energy and conformational landscape of filamentous actin and microtubules.
    Physical chemistry chemical physics : PCCP, 2018, Nov-21, Volume: 20, Issue:45

    Topics: Actins; Animals; Cattle; Methylamines; Microtubules; Pressure; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Stability; Protein Unfolding; Rabbits; Solvents; Thermodynamics; Transition Temperature; Tubulin; Urea

2018
Protective Effect of Biological Osmolytes against Heat- and Chaotropic Agent-Induced Denaturation of
    Journal of microbiology and biotechnology, 2018, Sep-28, Volume: 28, Issue:9

    Topics: Bacillus licheniformis; Escherichia coli; gamma-Glutamyltransferase; Glycerol; Guanidine; Hot Temperature; Methylamines; Osmolar Concentration; Protein Denaturation; Protein Stability; Protein Structure, Secondary; Recombinant Proteins; Sorbitol; Spectrometry, Fluorescence; Sucrose; Urea

2018
Exploring the effects of cosolutes and crowding on the volumetric and kinetic profile of the conformational dynamics of a poly dA loop DNA hairpin: a single-molecule FRET study.
    Nucleic acids research, 2019, 01-25, Volume: 47, Issue:2

    Topics: Cations; DNA; Ficoll; Fluorescence Resonance Energy Transfer; Kinetics; Methylamines; Nucleic Acid Conformation; Poly A; Urea

2019
Dynamical Effects of Trimethylamine N-Oxide on Aqueous Solutions of Urea.
    The journal of physical chemistry. B, 2019, 02-07, Volume: 123, Issue:5

    Topics: Diffusion; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Solutions; Urea; Water

2019
Dynamics of TMAO and urea in the hydration shell of the protein SNase.
    Physical chemistry chemical physics : PCCP, 2019, Sep-21, Volume: 21, Issue:35

    Topics: Endodeoxyribonucleases; Methylamines; Molecular Dynamics Simulation; Protein Stability; Solvents; Urea; Water

2019
Persistent homology analysis of osmolyte molecular aggregation and their hydrogen-bonding networks.
    Physical chemistry chemical physics : PCCP, 2019, Oct-07, Volume: 21, Issue:37

    Topics: Entropy; Hydrogen; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Protein Aggregation, Pathological; Structural Homology, Protein; Urea

2019
Combined co-solvent and pressure effect on kinetics of a peptide hydrolysis: an activity-based approach.
    Physical chemistry chemical physics : PCCP, 2019, Oct-28, Volume: 21, Issue:40

    Topics: Chymotrypsin; Dimethyl Sulfoxide; Hydrolysis; Kinetics; Methylamines; Phenylalanine; Pressure; Solvents; Thermodynamics; Urea; Water

2019
Changes in Water Soluble Uremic Toxins and Urinary Acute Kidney Injury Biomarkers After 10- and 100-km Runs.
    International journal of environmental research and public health, 2019, 10-28, Volume: 16, Issue:21

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Albuminuria; Arginine; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Humans; Lipocalin-2; Lipocalins; Male; Methylamines; Middle Aged; Running; Urea; Uric Acid; Water

2019
Dynamical Model for the Counteracting Effects of Trimethylamine
    The journal of physical chemistry. B, 2020, 03-12, Volume: 124, Issue:10

    Topics: Hydrogen Bonding; Methylamines; Urea; Water

2020
Weighted persistent homology for osmolyte molecular aggregation and hydrogen-bonding network analysis.
    Scientific reports, 2020, 06-16, Volume: 10, Issue:1

    Topics: Entropy; Hydrogen Bonding; Methylamines; Models, Chemical; Molecular Dynamics Simulation; Molecular Structure; Protein Folding; Solutions; Urea

2020
Pressure, Peptides, and a Piezolyte: Structural Analysis of the Effects of Pressure and Trimethylamine-
    The journal of physical chemistry. B, 2020, 07-30, Volume: 124, Issue:30

    Topics: Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Peptides; Urea; Water

2020
The interaction strength of an intrinsically disordered protein domain with its binding partner is little affected by very different cosolutes.
    Physical chemistry chemical physics : PCCP, 2020, Dec-16, Volume: 22, Issue:47

    Topics: Betaine; CREB-Binding Protein; Entropy; Glycine; Humans; Intrinsically Disordered Proteins; Kinetics; Methylamines; Protein Binding; Protein Domains; Proto-Oncogene Proteins c-myb; Temperature; Urea

2020
Interactions of a DNA G-quadruplex with TMAO and urea: a molecular dynamics study on co-solute compensation mechanisms.
    Physical chemistry chemical physics : PCCP, 2021, Jan-21, Volume: 23, Issue:2

    Topics: DNA; G-Quadruplexes; Hydrogen Bonding; Methylamines; Molecular Dynamics Simulation; Thermodynamics; Urea; Water

2021
Potential interactions between uraemic toxins and drugs: an application in kidney transplant recipients treated with calcineurin inhibitors.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2022, 10-19, Volume: 37, Issue:11

    Topics: Aged; Calcineurin Inhibitors; Cross-Sectional Studies; Cyclosporine; Humans; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Tacrolimus; Transplant Recipients; Urea; Uremic Toxins

2022
How Do Urea and Trimethylamine
    The journal of physical chemistry. B, 2021, 09-16, Volume: 125, Issue:36

    Topics: Dehydration; Humans; Lipids; Methylamines; Urea

2021
Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions.
    International journal of molecular sciences, 2021, Aug-28, Volume: 22, Issue:17

    Topics: Chemical Phenomena; Glycine; Glycylglycine; Methylamines; Molecular Dynamics Simulation; Osmotic Pressure; Peptides; Solutions; Spectroscopy, Fourier Transform Infrared; Urea; Water

2021
Can Urea and Trimethylamine-
    The journal of physical chemistry. B, 2022, 02-24, Volume: 126, Issue:7

    Topics: Lipids; Methylamines; Solutions; Urea; Water

2022
Hydrophobic association and solvation of neopentane in urea, TMAO and urea-TMAO solutions.
    Physical chemistry chemical physics : PCCP, 2022, Mar-16, Volume: 24, Issue:11

    Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Molecular Dynamics Simulation; Pentanes; Solutions; Urea; Water

2022
Urea ameliorates trimethylamine N-oxide-Induced aggregation of intrinsically disordered α-casein protein: the other side of the urea-methylamine counteraction.
    Journal of biomolecular structure & dynamics, 2023, Volume: 41, Issue:8

    Topics: Amyloid beta-Peptides; Caseins; HEK293 Cells; Humans; Intrinsically Disordered Proteins; Methylamines; Urea

2023
The protein-stabilizing effects of TMAO in aqueous and non-aqueous conditions.
    Physical chemistry chemical physics : PCCP, 2022, Sep-14, Volume: 24, Issue:35

    Topics: Hydrophobic and Hydrophilic Interactions; Methylamines; Proteins; Solvents; Urea; Water

2022
A study of the interaction between TMAO and urea in water using NMR spectroscopy.
    Physical chemistry chemical physics : PCCP, 2022, Sep-14, Volume: 24, Issue:35

    Topics: Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methylamines; Urea; Water

2022
Urea counteracts trimethylamine N-oxide (TMAO) compaction of lipid membranes by modifying van der Waals interactions.
    Journal of colloid and interface science, 2023, Volume: 629, Issue:Pt A

    Topics: Animals; Lipids; Methylamines; Nucleic Acids; Proteins; Urea

2023
TMAO: Protecting proteins from feeling the heat.
    Biophysical journal, 2023, 04-04, Volume: 122, Issue:7

    Topics: Animals; Hot Temperature; Methylamines; Proteins; Urea; Water

2023
Myosin light chain of shark fast skeletal muscle exhibits intrinsic urea-resistibility.
    Scientific reports, 2023, 03-25, Volume: 13, Issue:1

    Topics: Animals; Muscle, Skeletal; Myosin Light Chains; Sharks; Urea

2023
Effect of Cosolutes on the Aggregation of a Tau Fragment: A Combined Experimental and Simulation Approach.
    The journal of physical chemistry. B, 2023, 05-11, Volume: 127, Issue:18

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Alzheimer Disease; Humans; Molecular Dynamics Simulation; tau Proteins; Urea

2023