urea has been researched along with sb 705498 in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 14 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davis, JB; Fell, S; Gunthorpe, MJ; Jerman, JC; Rami, HK; Randall, AD; Sanderson, D; Sargent, B; Smart, D; Stemp, G; Stevens, AJ; Thompson, M | 1 |
| Arpino, S; Brough, S; Davis, JB; Egerton, J; Gunthorpe, MJ; Hannan, SL; Holland, VA; Jerman, JC; Lappin, SC; Rami, HK; Randall, A; Smart, D; Smith, GD; Thompson, M; Winborn, K; Wright, J | 1 |
| Appleby, JM; Aylott, MC; Brooke, AC; Bullman, JN; Chizh, BA; Gray, EJ; Lai, RY; Napolitano, A; O'Donnell, MB; Wang, J; Williams, PM | 1 |
| Conway, SJ | 1 |
| Lambert, DG | 1 |
| Hutchins, CW; Kort, ME; Kym, PR | 1 |
| Aerssens, J; Boeckxstaens, GE; Bulmer, DC; de Hoogt, R; de Jonge, WJ; Klooker, TK; Lee, K; Peeters, PJ; Stanisor, OI; van den Wijngaard, RM; van der Coelen, D; Welting, O; Wouters, MM | 1 |
| Appleby, JM; Chizh, BA; Davis, JB; Hoskin, KL; Lambert, GA; Zagami, AS | 1 |
| Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A | 1 |
| Alenmyr, L; Andersson, M; Greiff, L; Högestätt, ED; Sterner, O; Zygmunt, PM | 1 |
| Adcock, JJ; Delescluse, I; Mace, H | 1 |
| Kort, ME; Kym, PR | 1 |
| Busby, D; Butler, J; Dressman, J; Psachoulias, D; Reppas, C; Symillides, M; Vertzoni, M | 1 |
| Biggadike, K; Busza, A; Campbell, S; Changani, K; Coe, D; Denyer, J; Dinnewell, L; Hotee, S; Lines, M; Pindoria, K; Saklatvala, P; Thompson, SA; Vitulli, G | 1 |
| Bareille, P; Bentley, J; Denyer, J; Horak, F; Lemell, P; Murdoch, RD; Smart, K; Yarnall, K; Zieglmayer, P; Zieglmayer, R | 1 |
| Beerahee, M; Denyer, J; Fokkens, W; Holland, C; Newlands, A; Segboer, C; Smart, K; Terreehorst, I; Tsitoura, DC; van Drunen, C | 1 |
| Bareille, P; Bentley, J; Denyer, J; Murdoch, RD; Newlands, A; Patel, D; Smart, K; Yarnall, K | 1 |
| Dockry, R; Holt, K; Kelsall, A; Khalid, S; Murdoch, R; Newlands, A; Smart, K; Smith, JA; Woodcock, A | 1 |
| Fernando, D; Gibson, RA; McCallum, S; Mistry, H; Robertson, J; Wyres, M; Yosipovitch, G | 1 |
| Huang, QY; Wang, D; Yang, F; Yang, LL; Yuan, GR; Zhou, L | 1 |
| Bae, IH; Burns, A; Choi, G; Choi, JK; Fagg, R; Gatfield, KM; Lee, CS; Naidoo, AA; Park, M; Park, YH; Powell, AJ; Vidgeon-Hart, M | 1 |
| Liu, L; Sun, T; Wang, L; Zhang, L | 1 |
2 review(s) available for urea and sb 705498
| Article | Year |
|---|---|
TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.
Topics: Animals; Benzimidazoles; Capsaicin; Humans; Ligands; Pyrrolidines; Sodium Channel Blockers; TRPV Cation Channels; Urea | 2008 |
TRPV1 antagonists: clinical setbacks and prospects for future development.
Topics: Analgesics, Non-Narcotic; Benzimidazoles; Benzothiazoles; Body Temperature Regulation; Humans; Indazoles; Pyridines; Pyrimidines; Pyrrolidines; TRPV Cation Channels; Urea | 2012 |
7 trial(s) available for urea and sb 705498
| Article | Year |
|---|---|
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans.
Topics: Administration, Oral; Adolescent; Adult; Analgesics; Cohort Studies; Dose-Response Relationship, Drug; Female; Hot Temperature; Humans; Hyperalgesia; Inflammation; Male; Middle Aged; Pain Measurement; Placebo Effect; Pyrrolidines; Signal Transduction; Treatment Outcome; TRPV Cation Channels; Urea | 2007 |
Effect of mucosal TRPV1 inhibition in allergic rhinitis.
Topics: Adult; Capsaicin; Cross-Over Studies; Double-Blind Method; Female; Fluorometry; HEK293 Cells; Humans; Male; Pyrrolidines; Rhinitis, Allergic, Seasonal; TRPV Cation Channels; Urea; Young Adult | 2012 |
The effects of a TRPV1 antagonist, SB-705498, in the treatment of seasonal allergic rhinitis.
Topics: Administration, Intranasal; Adult; Androstadienes; Anti-Allergic Agents; Austria; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Fluticasone; Humans; Male; Pyrrolidines; Rhinitis, Allergic, Seasonal; Treatment Outcome; TRPV Cation Channels; Urea | 2013 |
Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist.
Topics: Adolescent; Adult; Capsaicin; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrrolidines; Rhinitis; TRPV Cation Channels; Urea; Visual Analog Scale | 2014 |
TRPV1 inhibition does not prevent cold dry air-elicited symptoms in non-allergic rhinitis.
Topics: Adult; Cold Temperature; Double-Blind Method; Female; Humans; Male; Middle Aged; Pyrrolidines; Rhinitis; TRPV Cation Channels; Urea | 2014 |
Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial.
Topics: Administration, Inhalation; Adult; Aged; Animals; Antitussive Agents; Capsaicin; Chronic Disease; Cough; Cross-Over Studies; Double-Blind Method; Female; Gene Expression; Humans; Male; Middle Aged; Pyrrolidines; Quality of Life; Severity of Illness Index; Treatment Outcome; TRPV Cation Channels; Urea | 2014 |
A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers.
Topics: Administration, Topical; Adult; Capsaicin; Healthy Volunteers; Histamine; Humans; Male; Middle Aged; Pruritus; Pyrrolidines; Skin; TRPV Cation Channels; Urea | 2014 |
13 other study(ies) available for urea and sb 705498
| Article | Year |
|---|---|
Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Topics: Administration, Oral; Animals; Capsaicin; Cell Line; Drug Design; Guinea Pigs; Humans; Molecular Structure; Pyrrolidines; Rats; Structure-Activity Relationship; TRPV Cation Channels; Urea | 2006 |
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Topics: Acids; Animals; Binding, Competitive; Calcium Signaling; Capsaicin; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Hot Temperature; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Molecular Structure; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Transfection; TRPV Cation Channels; Urea | 2007 |
Capsaicin receptor antagonists: a promising new addition to the pain clinic.
Topics: Analgesics; Anilides; Cinnamates; Humans; Pain; Pain Clinics; Pyrrolidines; TRPV Cation Channels; Urea | 2009 |
Analgesic potential of TRPV1 antagonists.
Topics: Analgesics; Animals; Benzothiazoles; Indazoles; Models, Molecular; Pyrimidines; Pyrrolidines; Structure-Activity Relationship; Temperature; TRPV Cation Channels; Urea | 2009 |
Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats.
Topics: Animals; Blotting, Western; Capsaicin; Catheterization; Colon; Drinking Behavior; Female; Immunohistochemistry; Macrophages; Mast Cells; Maternal Deprivation; Nerve Growth Factor; Pregnancy; Pyrrolidines; Rats; Rats, Long-Evans; Stress, Psychological; T-Lymphocytes; Transcription, Genetic; TRPV Cation Channels; Urea | 2009 |
The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission.
Topics: Analgesics; Animals; Blood Pressure; Cats; Cerebrovascular Circulation; Disease Models, Animal; Dura Mater; Electric Stimulation; Evoked Potentials; Face; Inflammation; Inflammation Mediators; Injections, Intravenous; Migraine Disorders; Nerve Fibers, Myelinated; Pain; Pain Measurement; Pain Threshold; Pyrrolidines; Reaction Time; Skin; Synaptic Transmission; Time Factors; Trigeminal Caudal Nucleus; Trigeminal Nerve; TRPV Cation Channels; Urea | 2009 |
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea | 2010 |
Inhibition of airway hyper-responsiveness by TRPV1 antagonists (SB-705498 and PF-04065463) in the unanaesthetized, ovalbumin-sensitized guinea pig.
Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Allergens; Animals; Atropine; Bronchial Hyperreactivity; Bronchoconstriction; Cetirizine; Cyclopropanes; Guinea Pigs; Histamine; Histamine H1 Antagonists, Non-Sedating; Male; Muscarinic Antagonists; Ovalbumin; Pyrrolidines; Sulfonamides; TRPV Cation Channels; Urea | 2012 |
An in vitro methodology for forecasting luminal concentrations and precipitation of highly permeable lipophilic weak bases in the fasted upper small intestine.
Topics: Antifungal Agents; Dipyridamole; Fasting; Humans; Imidazoles; Intestinal Absorption; Intestine, Small; Ketoconazole; Models, Biological; Permeability; Platelet Aggregation Inhibitors; Pyridines; Pyrrolidines; Solubility; TRPV Cation Channels; Urea | 2012 |
Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig.
Topics: Administration, Intranasal; Administration, Oral; Animals; Anti-Allergic Agents; Capsaicin; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Compounding; Female; Guinea Pigs; Male; Nasal Mucosa; Parasympathetic Nervous System; Parasympatholytics; Particle Size; Pyrrolidines; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Secretory Pathway; Sensory System Agents; Trigeminal Ganglion; TRPV Cation Channels; Urea | 2013 |
Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats.
Topics: Animals; Calcium; Cell Line; Drinking; Gadolinium; HEK293 Cells; Heme Oxygenase (Decyclizing); Humans; Hydrogen-Ion Concentration; Hypoxia; Male; Morpholines; Neurons; Pyrroles; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium; Subfornical Organ; Temperature; TRPV Cation Channels; Urea | 2016 |
Do TRPV1 antagonists increase the risk for skin tumourigenesis? A collaborative in vitro and in vivo assessment.
Topics: Acrylamides; Animals; Anthracenes; Bridged Bicyclo Compounds, Heterocyclic; Capsaicin; Cell Line; Cell Proliferation; Cell Survival; Cocarcinogenesis; Female; Humans; Keratinocytes; Mice; Mice, Hairless; Piperidines; Primary Cell Culture; Pyridines; Pyrrolidines; Risk; Skin Neoplasms; TRPV Cation Channels; Urea | 2018 |
The research of the possible mechanism and the treatment for capsaicin-induced cough.
Topics: Animals; Antitussive Agents; Calcitonin Gene-Related Peptide; Capsaicin; Chronic Disease; Codeine; Cough; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Guinea Pigs; Male; Neurokinin A; Pyrrolidines; Substance P; TRPV Cation Channels; Urea | 2018 |